locus-tag	class	description
CDC35_RS00005	COG0745	RESPONSE REGULATOR receiver
CDC35_RS00020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CDC35_RS00025	COG1215	transferase activity, transferring glycosyl groups
CDC35_RS00040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDC35_RS00045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CDC35_RS00050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDC35_RS00055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC35_RS00060	COG0824	Thioesterase
CDC35_RS00065	COG0010	Belongs to the arginase family
CDC35_RS00070	COG0375	protein maturation
CDC35_RS00075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDC35_RS00085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC35_RS00090	COG1116	anion transmembrane transporter activity
CDC35_RS00095	COG2385	sporulation resulting in formation of a cellular spore
CDC35_RS00125	COG0432	Pfam Uncharacterised protein family UPF0047
CDC35_RS00130	COG0113	porphobilinogen synthase activity
CDC35_RS00140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDC35_RS00145	COG0148	phosphopyruvate hydratase activity
CDC35_RS00150	COG0058	SHG alpha-glucan phosphorylase activity
CDC35_RS00160	COG1193	negative regulation of DNA recombination
CDC35_RS00165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDC35_RS00170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CDC35_RS00180	COG3012	SEC-C Motif Domain Protein
CDC35_RS00190	COG0629	single-stranded DNA binding
CDC35_RS00200	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS00210	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CDC35_RS00215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC35_RS00220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDC35_RS00230	COG0384	phenazine biosynthesis protein PhzF
CDC35_RS00240	COG1847	R3H domain protein
CDC35_RS00245	COG0706	membrane insertase activity
CDC35_RS00255	COG0594	ribonuclease P activity
CDC35_RS00260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CDC35_RS00275	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CDC35_RS00295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CDC35_RS00310	COG0318	PFAM AMP-dependent synthetase and ligase
CDC35_RS00315	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CDC35_RS00320	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CDC35_RS00350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CDC35_RS00380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CDC35_RS00385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDC35_RS00405	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CDC35_RS00425	COG1104	cysteine desulfurase activity
CDC35_RS00440	COG3118	belongs to the thioredoxin family
CDC35_RS00455	COG0586	Pfam SNARE associated Golgi protein
CDC35_RS00470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CDC35_RS00475	COG0436	Aminotransferase
CDC35_RS00550	COG0367	asparagine synthase
CDC35_RS00565	COG0367	asparagine synthase
CDC35_RS00580	COG0489	protein tyrosine kinase activity
CDC35_RS00610	COG0297	glycogen (starch) synthase activity
CDC35_RS00630	COG1045	serine acetyltransferase
CDC35_RS00650	COG1216	Glycosyl transferase, family 2
CDC35_RS00660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC35_RS00660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC35_RS00680	COG1842	Phage shock protein A
CDC35_RS00690	COG0436	Aminotransferase
CDC35_RS00700	COG0515	serine threonine protein kinase
CDC35_RS00715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CDC35_RS00740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDC35_RS00770	COG0592	DNA-directed DNA polymerase activity
CDC35_RS00785	COG0442	prolyl-tRNA aminoacylation
CDC35_RS00800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDC35_RS00830	COG1266	CAAX protease self-immunity
CDC35_RS00835	COG3659	wide pore channel activity
CDC35_RS00845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDC35_RS00855	COG0395	ABC-type sugar transport system, permease component
CDC35_RS00870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDC35_RS00875	COG0268	Binds directly to 16S ribosomal RNA
CDC35_RS00880	COG0084	hydrolase, TatD family'
CDC35_RS00885	COG0085	RNA polymerase activity
CDC35_RS00890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CDC35_RS00895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CDC35_RS00910	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CDC35_RS00920	COG0343	queuine tRNA-ribosyltransferase activity
CDC35_RS00930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CDC35_RS00935	COG5001	Diguanylate cyclase
CDC35_RS00935	COG4251	negative regulation of phosphorylation
CDC35_RS00935	COG3706	GGDEF domain
CDC35_RS00935	COG2203	Gaf domain
CDC35_RS00940	COG0653	protein targeting
CDC35_RS00945	COG0277	FAD linked oxidase domain protein
CDC35_RS00950	COG0247	lactate metabolic process
CDC35_RS00955	COG3429	Glucose-6-phosphate dehydrogenase subunit
CDC35_RS00955	COG3409	Peptidoglycan-binding domain 1 protein
CDC35_RS00960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CDC35_RS00965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDC35_RS00970	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CDC35_RS00990	COG3842	ATPase activity
CDC35_RS01015	COG0745	RESPONSE REGULATOR receiver
CDC35_RS01020	COG0778	Nitroreductase
CDC35_RS01025	COG0501	Belongs to the peptidase M48B family
CDC35_RS01035	COG4783	chaperone-mediated protein folding
CDC35_RS01040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDC35_RS01070	COG3344	reverse transcriptase
CDC35_RS01080	COG1598	PFAM Uncharacterised protein family UPF0150
CDC35_RS01085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CDC35_RS01120	COG0701	Predicted permease
CDC35_RS01125	COG2226	methyltransferase
CDC35_RS01130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CDC35_RS01140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDC35_RS01145	COG1797	cobyrinic acid a,c-diamide synthase activity
CDC35_RS01155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDC35_RS01175	COG0793	Belongs to the peptidase S41A family
CDC35_RS01185	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CDC35_RS01190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDC35_RS01195	COG0745	RESPONSE REGULATOR receiver
CDC35_RS01200	COG1799	cell septum assembly
CDC35_RS01205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CDC35_RS01240	COG0411	ABC transporter
CDC35_RS01255	COG1598	PFAM Uncharacterised protein family UPF0150
CDC35_RS01265	COG1247	-acetyltransferase
CDC35_RS01280	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDC35_RS01285	COG0824	Thioesterase
CDC35_RS01300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC35_RS01305	COG0581	inorganic phosphate transmembrane transporter activity
CDC35_RS01310	COG0573	inorganic phosphate transmembrane transporter activity
CDC35_RS01315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDC35_RS01320	COG0640	Transcriptional regulator
CDC35_RS01325	COG0745	RESPONSE REGULATOR receiver
CDC35_RS01345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CDC35_RS01365	COG1902	pentaerythritol trinitrate reductase activity
CDC35_RS01370	COG4221	oxidoreductase activity
CDC35_RS01385	COG0811	peptide transport
CDC35_RS01395	COG1196	nuclear chromosome segregation
CDC35_RS01395	COG0739	heme binding
CDC35_RS01395	COG0741	lytic transglycosylase activity
CDC35_RS01400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CDC35_RS01405	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CDC35_RS01430	COG0431	NADPH-dependent FMN reductase
CDC35_RS01440	COG2304	oxidoreductase activity
CDC35_RS01470	COG2124	cytochrome p450
CDC35_RS01475	COG1231	oxidoreductase activity
CDC35_RS01490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CDC35_RS01490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDC35_RS01495	COG0632	four-way junction helicase activity
CDC35_RS01515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDC35_RS01520	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CDC35_RS01535	COG1672	PFAM Archaeal ATPase
CDC35_RS01540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDC35_RS01565	COG1122	ATPase activity
CDC35_RS01570	COG0357	Ribosomal RNA small subunit methyltransferase G
CDC35_RS01575	COG0784	Response regulator, receiver
CDC35_RS01580	COG0494	nUDIX hydrolase
CDC35_RS01590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC35_RS01610	COG1372	Participates in initiation and elongation during chromosome replication
CDC35_RS01610	COG0187	DNA topoisomerase II activity
CDC35_RS01615	COG1357	PFAM Pentapeptide repeats (8 copies)
CDC35_RS01615	COG0515	serine threonine protein kinase
CDC35_RS01625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC35_RS01660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC35_RS01675	COG3932	Exopolysaccharide synthesis, ExoD
CDC35_RS01690	COG0436	Aminotransferase
CDC35_RS01700	COG2885	chlorophyll binding
CDC35_RS01730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDC35_RS01735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDC35_RS01755	COG2813	Specifically methylates the guanine in position
CDC35_RS01765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDC35_RS01770	COG0242	peptide deformylase activity
CDC35_RS01775	COG1940	carbohydrate kinase activity
CDC35_RS01780	COG0398	Pfam SNARE associated Golgi protein
CDC35_RS01790	COG3536	Protein conserved in bacteria
CDC35_RS01830	COG3842	ATPase activity
CDC35_RS01845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CDC35_RS01845	COG0284	orotidine-5'-phosphate decarboxylase activity
CDC35_RS01870	COG1492	cobalamin metabolic process
CDC35_RS01880	COG5002	protein histidine kinase activity
CDC35_RS01885	COG0745	RESPONSE REGULATOR receiver
CDC35_RS01890	COG0745	RESPONSE REGULATOR receiver
CDC35_RS01910	COG2205	protein histidine kinase activity
CDC35_RS01915	COG1606	tRNA processing
CDC35_RS01975	COG1487	ribonuclease activity
CDC35_RS01980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDC35_RS01985	COG3119	arylsulfatase activity
CDC35_RS01990	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CDC35_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
CDC35_RS02010	COG0784	Response regulator, receiver
CDC35_RS02015	COG0745	RESPONSE REGULATOR receiver
CDC35_RS02035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CDC35_RS02050	COG0322	excinuclease ABC activity
CDC35_RS02070	COG0702	epimerase
CDC35_RS02100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CDC35_RS02110	COG0765	amino acid transport
CDC35_RS02115	COG3659	wide pore channel activity
CDC35_RS02120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDC35_RS02135	COG5002	protein histidine kinase activity
CDC35_RS02140	COG0704	Plays a role in the regulation of phosphate uptake
CDC35_RS02145	COG3659	wide pore channel activity
CDC35_RS02165	COG0460	homoserine dehydrogenase
CDC35_RS02170	COG2226	methyltransferase
CDC35_RS02180	COG0457	Tetratricopeptide repeat
CDC35_RS02205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC35_RS02230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC35_RS02240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CDC35_RS02250	COG0724	RNA recognition motif
CDC35_RS02255	COG2239	Acts as a magnesium transporter
CDC35_RS02270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC35_RS02275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC35_RS02300	COG0702	epimerase
CDC35_RS02320	COG0009	L-threonylcarbamoyladenylate synthase
CDC35_RS02325	COG2890	protein-(glutamine-N5) methyltransferase activity
CDC35_RS02350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC35_RS02395	COG5002	protein histidine kinase activity
CDC35_RS02405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CDC35_RS02410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CDC35_RS02415	COG4251	negative regulation of phosphorylation
CDC35_RS02425	COG2205	protein histidine kinase activity
CDC35_RS02430	COG1408	metallophosphoesterase
CDC35_RS02435	COG4221	oxidoreductase activity
CDC35_RS02450	COG0511	ligase activity, forming carbon-carbon bonds
CDC35_RS02455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CDC35_RS02460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDC35_RS02465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CDC35_RS02470	COG5002	protein histidine kinase activity
CDC35_RS02475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC35_RS02485	COG1187	pseudouridine synthase activity
CDC35_RS02495	COG0745	RESPONSE REGULATOR receiver
CDC35_RS02510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CDC35_RS02535	COG0137	argininosuccinate synthase activity
CDC35_RS02540	COG1091	dTDP-4-dehydrorhamnose reductase activity
CDC35_RS02555	COG1049	propionate catabolic process, 2-methylcitrate cycle
CDC35_RS02560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CDC35_RS02570	COG0133	tryptophan synthase activity
CDC35_RS02585	COG0494	nUDIX hydrolase
CDC35_RS02600	COG0802	atpase or kinase
CDC35_RS02630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDC35_RS02690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDC35_RS02695	COG0571	ribonuclease III activity
CDC35_RS02700	COG1233	COG1233 Phytoene dehydrogenase and related
CDC35_RS02720	COG0471	metal ion transport
CDC35_RS02730	COG1285	pathogenesis
CDC35_RS02735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CDC35_RS02750	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CDC35_RS02755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC35_RS02760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDC35_RS02765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC35_RS02770	COG0156	8-amino-7-oxononanoate synthase activity
CDC35_RS02775	COG1191	sigma factor activity
CDC35_RS02790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC35_RS02795	COG0805	protein transport
CDC35_RS02800	COG0783	Belongs to the Dps family
CDC35_RS02820	COG0398	Pfam SNARE associated Golgi protein
CDC35_RS02840	COG5002	protein histidine kinase activity
CDC35_RS02840	COG5001	Diguanylate cyclase
CDC35_RS02870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDC35_RS02875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CDC35_RS02880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC35_RS02890	COG0038	chloride channel
CDC35_RS02905	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CDC35_RS02910	COG0504	CTP synthase activity
CDC35_RS02915	COG0406	alpha-ribazole phosphatase activity
CDC35_RS02920	COG1357	PFAM Pentapeptide repeats (8 copies)
CDC35_RS02925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC35_RS02940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CDC35_RS02960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CDC35_RS02965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC35_RS02970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC35_RS02975	COG1116	anion transmembrane transporter activity
CDC35_RS02975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC35_RS02980	COG1116	anion transmembrane transporter activity
CDC35_RS03000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDC35_RS03010	COG0489	protein tyrosine kinase activity
CDC35_RS03015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CDC35_RS03040	COG3210	domain, Protein
CDC35_RS03045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CDC35_RS03065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC35_RS03070	COG1136	(ABC) transporter
CDC35_RS03075	COG3239	Fatty acid desaturase
CDC35_RS03085	COG1214	PFAM Peptidase M22, glycoprotease
CDC35_RS03090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC35_RS03115	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CDC35_RS03120	COG3290	protein histidine kinase activity
CDC35_RS03120	COG3829	transcription factor binding
CDC35_RS03125	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CDC35_RS03130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDC35_RS03145	COG2211	Major facilitator Superfamily
CDC35_RS03155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CDC35_RS03175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CDC35_RS03175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDC35_RS03180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC35_RS03185	COG1196	nuclear chromosome segregation
CDC35_RS03225	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CDC35_RS03235	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CDC35_RS03245	COG1872	DUF167
CDC35_RS03250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CDC35_RS03255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC35_RS03265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC35_RS03270	COG0776	regulation of translation
CDC35_RS03305	COG0601	transmembrane transport
CDC35_RS03315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CDC35_RS03320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDC35_RS03325	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDC35_RS03330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDC35_RS03335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC35_RS03340	COG4783	chaperone-mediated protein folding
CDC35_RS03345	COG0800	Aldolase
CDC35_RS03360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDC35_RS03445	COG1304	FMN binding
CDC35_RS03450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CDC35_RS03455	COG0415	Belongs to the DNA photolyase family
CDC35_RS03465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC35_RS03470	COG4208	sulfate ABC transporter
CDC35_RS03475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CDC35_RS03485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDC35_RS03490	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC35_RS03495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC35_RS03500	COG0484	heat shock protein binding
CDC35_RS03505	COG0189	ligase activity
CDC35_RS03515	COG0454	-acetyltransferase
CDC35_RS03520	COG1090	epimerase
CDC35_RS03540	COG1393	Belongs to the ArsC family
CDC35_RS03545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC35_RS03555	COG0598	Magnesium transport protein CorA
CDC35_RS03560	COG0768	penicillin binding
CDC35_RS03565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDC35_RS03570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CDC35_RS03575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CDC35_RS03590	COG1121	(ABC) transporter
CDC35_RS03595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDC35_RS03620	COG0523	cobalamin synthesis protein
CDC35_RS03645	COG0259	pyridoxamine-phosphate oxidase activity
CDC35_RS03650	COG0792	nuclease activity
CDC35_RS03655	COG5001	Diguanylate cyclase
CDC35_RS03660	COG0830	nickel cation binding
CDC35_RS03665	COG2226	methyltransferase
CDC35_RS03680	COG2252	PERMEase
CDC35_RS03705	COG1120	ATPase activity
CDC35_RS03710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDC35_RS03715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDC35_RS03760	COG0315	cyclic pyranopterin monophosphate synthase activity
CDC35_RS03770	COG0312	modulator of DNA gyrase
CDC35_RS03780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDC35_RS03820	COG2201	protein-glutamate methylesterase activity
CDC35_RS03865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDC35_RS03890	COG0612	Peptidase, M16
CDC35_RS03895	COG0742	ribosomal rna small subunit methyltransferase
CDC35_RS03920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC35_RS03925	COG0435	Glutathione S-transferase
CDC35_RS03930	COG2273	Hydrolase Family 16
CDC35_RS03930	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CDC35_RS03940	COG2226	methyltransferase
CDC35_RS03945	COG0577	efflux transmembrane transporter activity
CDC35_RS03945	COG1136	(ABC) transporter
CDC35_RS03960	COG2045	Belongs to the ComB family
CDC35_RS03975	COG4279	zinc finger
CDC35_RS03995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDC35_RS04015	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CDC35_RS04020	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CDC35_RS04035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDC35_RS04040	COG2003	Belongs to the UPF0758 family
CDC35_RS04050	COG1331	Highly conserved protein containing a thioredoxin domain
CDC35_RS04065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CDC35_RS04080	COG0004	ammonium transporteR
CDC35_RS04090	COG3001	Fructosamine kinase
CDC35_RS04100	COG2363	Small membrane protein
CDC35_RS04105	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS04125	COG1716	ATPase activity
CDC35_RS04125	COG0842	Transport permease protein
CDC35_RS04125	COG1131	(ABC) transporter
CDC35_RS04135	COG0489	protein tyrosine kinase activity
CDC35_RS04155	COG0587	DNA-directed DNA polymerase activity
CDC35_RS04185	COG0534	Mate efflux family protein
CDC35_RS04190	COG2323	membrane
CDC35_RS04205	COG0515	serine threonine protein kinase
CDC35_RS04205	COG2815	serine threonine protein kinase
CDC35_RS04230	COG5002	protein histidine kinase activity
CDC35_RS04235	COG0745	RESPONSE REGULATOR receiver
CDC35_RS04285	COG1802	Transcriptional regulator
CDC35_RS04355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDC35_RS04380	COG4969	Belongs to the N-Me-Phe pilin family
CDC35_RS04385	COG4968	Prepilin-type N-terminal cleavage methylation domain
CDC35_RS04410	COG4968	Prepilin-type N-terminal cleavage methylation domain
CDC35_RS04430	COG1131	(ABC) transporter
CDC35_RS04450	COG0735	belongs to the Fur family
CDC35_RS04465	COG0484	heat shock protein binding
CDC35_RS04470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDC35_RS04475	COG1619	proteins homologs of microcin C7 resistance protein MccF
CDC35_RS04505	COG2755	lipolytic protein G-D-S-L family
CDC35_RS04505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CDC35_RS04510	COG3291	Pkd domain containing protein
CDC35_RS04520	COG3063	Type IV pilus biogenesis stability protein PilW
CDC35_RS04525	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CDC35_RS04530	COG0575	Belongs to the CDS family
CDC35_RS04540	COG1982	Orn Lys Arg decarboxylase major
CDC35_RS04545	COG0745	RESPONSE REGULATOR receiver
CDC35_RS04550	COG0012	GTP binding
CDC35_RS04560	COG1733	regulation of RNA biosynthetic process
CDC35_RS04580	COG0616	signal peptide processing
CDC35_RS04595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC35_RS04610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDC35_RS04620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDC35_RS04625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CDC35_RS04630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDC35_RS04650	COG0542	response to heat
CDC35_RS04655	COG5002	protein histidine kinase activity
CDC35_RS04680	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS04700	COG0586	Pfam SNARE associated Golgi protein
CDC35_RS04710	COG0617	tRNA 3'-terminal CCA addition
CDC35_RS04740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CDC35_RS04770	COG3848	Pyruvate phosphate dikinase
CDC35_RS04770	COG0574	Belongs to the PEP-utilizing enzyme family
CDC35_RS04775	COG1253	flavin adenine dinucleotide binding
CDC35_RS04795	COG1309	transcriptional regulator
CDC35_RS04805	COG0531	amino acid
CDC35_RS04815	COG1121	(ABC) transporter
CDC35_RS04820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDC35_RS04825	COG1247	-acetyltransferase
CDC35_RS04835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC35_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
CDC35_RS04860	COG1131	(ABC) transporter
CDC35_RS04870	COG0589	response to stress
CDC35_RS04875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDC35_RS04875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CDC35_RS04880	COG3344	reverse transcriptase
CDC35_RS04885	COG0515	serine threonine protein kinase
CDC35_RS04900	COG0439	Biotin carboxylase
CDC35_RS04925	COG1598	PFAM Uncharacterised protein family UPF0150
CDC35_RS04935	COG1429	ligase activity, forming nitrogen-metal bonds
CDC35_RS04945	COG0640	Transcriptional regulator
CDC35_RS04950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CDC35_RS04970	COG5002	protein histidine kinase activity
CDC35_RS04980	COG1592	Rubrerythrin
CDC35_RS04985	COG0723	plastoquinol--plastocyanin reductase activity
CDC35_RS05005	COG0105	UTP biosynthetic process
CDC35_RS05010	COG3659	wide pore channel activity
CDC35_RS05020	COG1132	(ABC) transporter
CDC35_RS05050	COG0745	RESPONSE REGULATOR receiver
CDC35_RS05070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC35_RS05070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC35_RS05075	COG0509	glycine decarboxylation via glycine cleavage system
CDC35_RS05080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDC35_RS05085	COG0686	Belongs to the AlaDH PNT family
CDC35_RS05090	COG1233	COG1233 Phytoene dehydrogenase and related
CDC35_RS05095	COG0590	tRNA wobble adenosine to inosine editing
CDC35_RS05110	COG0003	Pfam Anion-transporting ATPase
CDC35_RS05120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDC35_RS05135	COG1496	oxidoreductase activity
CDC35_RS05140	COG0233	cytoplasmic translational termination
CDC35_RS05145	COG0528	UMP kinase activity
CDC35_RS05150	COG3344	reverse transcriptase
CDC35_RS05160	COG0010	Belongs to the arginase family
CDC35_RS05165	COG0596	Alpha beta hydrolase
CDC35_RS05170	COG2226	methyltransferase
CDC35_RS05215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC35_RS05220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CDC35_RS05225	COG0259	pyridoxamine-phosphate oxidase activity
CDC35_RS05230	COG0390	transport system, permease component
CDC35_RS05235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CDC35_RS05240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CDC35_RS05270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CDC35_RS05280	COG0045	succinate-CoA ligase (ADP-forming) activity
CDC35_RS05295	COG0126	phosphoglycerate kinase activity
CDC35_RS05300	COG0640	Transcriptional regulator
CDC35_RS05310	COG0798	PFAM Bile acid sodium symporter
CDC35_RS05315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDC35_RS05325	COG3118	belongs to the thioredoxin family
CDC35_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
CDC35_RS05335	COG0110	maltose O-acetyltransferase activity
CDC35_RS05340	COG0454	-acetyltransferase
CDC35_RS05345	COG2962	Rard protein
CDC35_RS05350	COG0443	Heat shock 70 kDa protein
CDC35_RS05360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CDC35_RS05370	COG0489	protein tyrosine kinase activity
CDC35_RS05380	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS05435	COG0656	L-ascorbic acid biosynthetic process
CDC35_RS05450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CDC35_RS05455	COG0517	IMP dehydrogenase activity
CDC35_RS05455	COG1994	Peptidase M50
CDC35_RS05470	COG0436	Aminotransferase
CDC35_RS05475	COG0840	transmembrane signaling receptor activity
CDC35_RS05500	COG0288	reversible hydration of carbon dioxide
CDC35_RS05505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CDC35_RS05525	COG5592	hemerythrin HHE cation binding domain
CDC35_RS05530	COG1429	ligase activity, forming nitrogen-metal bonds
CDC35_RS05535	COG5002	protein histidine kinase activity
CDC35_RS05540	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CDC35_RS05595	COG0318	PFAM AMP-dependent synthetase and ligase
CDC35_RS05600	COG1260	myo-inositol-1-phosphate synthase
CDC35_RS05605	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CDC35_RS05620	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CDC35_RS05625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC35_RS05630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDC35_RS05635	COG1690	Belongs to the RtcB family
CDC35_RS05635	COG1690	Belongs to the RtcB family
CDC35_RS05660	COG1012	belongs to the aldehyde dehydrogenase family
CDC35_RS05665	COG0300	oxidoreductase activity
CDC35_RS05665	COG0318	PFAM AMP-dependent synthetase and ligase
CDC35_RS05665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC35_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
CDC35_RS05665	COG3321	synthase
CDC35_RS05675	COG0546	phosphoglycolate phosphatase activity
CDC35_RS05680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDC35_RS05745	COG0174	glutamine synthetase
CDC35_RS05755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC35_RS05760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS05790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CDC35_RS05795	COG0416	fatty acid biosynthetic process
CDC35_RS05820	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS05830	COG0515	serine threonine protein kinase
CDC35_RS05835	COG0784	Response regulator, receiver
CDC35_RS05860	COG0488	(ABC) transporter
CDC35_RS05870	COG0124	histidyl-tRNA synthetase
CDC35_RS05875	COG1131	(ABC) transporter
CDC35_RS05890	COG0489	protein tyrosine kinase activity
CDC35_RS05905	COG5002	protein histidine kinase activity
CDC35_RS05935	COG0419	ATPase involved in DNA repair
CDC35_RS05945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC35_RS05970	COG0612	Peptidase, M16
CDC35_RS05975	COG1253	flavin adenine dinucleotide binding
CDC35_RS05980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CDC35_RS05985	COG0596	Alpha beta hydrolase
CDC35_RS05995	COG0189	ligase activity
CDC35_RS05995	COG4067	protein conserved in archaea
CDC35_RS06000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDC35_RS06040	COG0582	viral genome integration into host DNA
CDC35_RS06050	COG0431	NADPH-dependent FMN reductase
CDC35_RS06055	COG1116	anion transmembrane transporter activity
CDC35_RS06060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC35_RS06070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC35_RS06075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC35_RS06085	COG1045	serine acetyltransferase
CDC35_RS06090	COG1285	pathogenesis
CDC35_RS06115	COG0372	Belongs to the citrate synthase family
CDC35_RS06135	COG1283	sodium-dependent phosphate transmembrane transporter activity
CDC35_RS06165	COG0529	Catalyzes the synthesis of activated sulfate
CDC35_RS06175	COG0488	(ABC) transporter
CDC35_RS06190	COG0606	chelatase, subunit chli
CDC35_RS06195	COG5001	Diguanylate cyclase
CDC35_RS06195	COG1716	ATPase activity
CDC35_RS06200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC35_RS06200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC35_RS06205	COG0612	Peptidase, M16
CDC35_RS06210	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CDC35_RS06230	COG0745	RESPONSE REGULATOR receiver
CDC35_RS06275	COG0358	DNA primase activity
CDC35_RS06280	COG0415	Belongs to the DNA photolyase family
CDC35_RS06290	COG2135	peptidase activity
CDC35_RS06330	COG0590	tRNA wobble adenosine to inosine editing
CDC35_RS06335	COG1309	transcriptional regulator
CDC35_RS06340	COG0824	Thioesterase
CDC35_RS06360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC35_RS06380	COG0778	Nitroreductase
CDC35_RS06385	COG2226	methyltransferase
CDC35_RS06400	COG0489	protein tyrosine kinase activity
CDC35_RS06410	COG3307	-O-antigen
CDC35_RS06420	COG1696	Membrane protein involved in D-alanine export
CDC35_RS06445	COG1748	Saccharopine dehydrogenase
CDC35_RS06485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC35_RS06490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CDC35_RS06495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC35_RS06515	COG1505	serine-type exopeptidase activity
CDC35_RS06530	COG3344	reverse transcriptase
CDC35_RS06565	COG0612	Peptidase, M16
CDC35_RS06575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CDC35_RS06580	COG3659	wide pore channel activity
CDC35_RS06605	COG0484	heat shock protein binding
CDC35_RS06610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CDC35_RS06615	COG1122	ATPase activity
CDC35_RS06620	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CDC35_RS06630	COG0310	cobalt ion transport
CDC35_RS06640	COG0751	glycine-tRNA ligase activity
CDC35_RS06645	COG1252	NADH dehydrogenase
CDC35_RS06660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CDC35_RS06665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDC35_RS06670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDC35_RS06695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CDC35_RS06715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CDC35_RS06720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDC35_RS06725	COG0573	inorganic phosphate transmembrane transporter activity
CDC35_RS06730	COG0581	inorganic phosphate transmembrane transporter activity
CDC35_RS06735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC35_RS06745	COG3794	PFAM blue (type 1) copper domain protein
CDC35_RS06750	COG2010	Cytochrome c
CDC35_RS06760	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CDC35_RS06800	COG2202	Pas domain
CDC35_RS06800	COG2205	protein histidine kinase activity
CDC35_RS06815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC35_RS06820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CDC35_RS06825	COG0572	uridine kinase
CDC35_RS06835	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDC35_RS06855	COG0514	ATP-dependent DNA helicase (RecQ)
CDC35_RS06860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDC35_RS06890	COG0028	Belongs to the TPP enzyme family
CDC35_RS06895	COG0457	Tetratricopeptide repeat
CDC35_RS06900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC35_RS06910	COG0047	phosphoribosylformylglycinamidine synthase activity
CDC35_RS06915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDC35_RS06920	COG0735	belongs to the Fur family
CDC35_RS06925	COG0542	response to heat
CDC35_RS06945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CDC35_RS06950	COG1381	Involved in DNA repair and RecF pathway recombination
CDC35_RS06955	COG2814	Major facilitator Superfamily
CDC35_RS06960	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS06965	COG1216	Glycosyl transferase, family 2
CDC35_RS06965	COG0463	Glycosyl transferase, family 2
CDC35_RS06990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDC35_RS06995	COG1215	transferase activity, transferring glycosyl groups
CDC35_RS07000	COG2226	methyltransferase
CDC35_RS07010	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS07015	COG1230	cation diffusion facilitator family transporter
CDC35_RS07055	COG0799	negative regulation of ribosome biogenesis
CDC35_RS07080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CDC35_RS07085	COG0450	alkyl hydroperoxide reductase
CDC35_RS07140	COG0003	Pfam Anion-transporting ATPase
CDC35_RS07145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC35_RS07155	COG0408	coproporphyrinogen oxidase activity
CDC35_RS07165	COG0024	Methionine aminopeptidase
CDC35_RS07175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC35_RS07180	COG0705	Rhomboid family
CDC35_RS07190	COG0583	DNA-binding transcription factor activity
CDC35_RS07195	COG1741	Belongs to the pirin family
CDC35_RS07205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDC35_RS07210	COG1970	mechanosensitive ion channel activity
CDC35_RS07230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CDC35_RS07230	COG0351	phosphomethylpyrimidine kinase
CDC35_RS07230	COG0352	thiamine-phosphate diphosphorylase activity
CDC35_RS07250	COG0483	inositol monophosphate 1-phosphatase activity
CDC35_RS07260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDC35_RS07275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CDC35_RS07305	COG4948	Mandelate Racemase Muconate Lactonizing
CDC35_RS07315	COG1175	transmembrane transport
CDC35_RS07320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CDC35_RS07340	COG2259	Doxx family
CDC35_RS07345	COG0149	triose-phosphate isomerase activity
CDC35_RS07355	COG0159	tryptophan synthase activity
CDC35_RS07370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDC35_RS07375	COG1943	Transposase
CDC35_RS07405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CDC35_RS07410	COG0542	response to heat
CDC35_RS07415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CDC35_RS07420	COG2255	four-way junction helicase activity
CDC35_RS07445	COG1403	HNH endonuclease
CDC35_RS07450	COG2814	Major facilitator Superfamily
CDC35_RS07455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDC35_RS07460	COG0719	Fe-S assembly protein
CDC35_RS07465	COG0396	ATPase activity
CDC35_RS07480	COG1372	Participates in initiation and elongation during chromosome replication
CDC35_RS07480	COG1372	Participates in initiation and elongation during chromosome replication
CDC35_RS07480	COG0305	Participates in initiation and elongation during chromosome replication
CDC35_RS07480	COG0305	Participates in initiation and elongation during chromosome replication
CDC35_RS07495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDC35_RS07510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC35_RS07515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDC35_RS07535	COG0784	Response regulator, receiver
CDC35_RS07535	COG2198	Histidine kinase
CDC35_RS07535	COG0643	Histidine kinase
CDC35_RS07540	COG0840	transmembrane signaling receptor activity
CDC35_RS07540	COG2203	Gaf domain
CDC35_RS07545	COG2203	Gaf domain
CDC35_RS07545	COG0840	transmembrane signaling receptor activity
CDC35_RS07560	COG0784	Response regulator, receiver
CDC35_RS07570	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CDC35_RS07575	COG0717	Belongs to the dCTP deaminase family
CDC35_RS07580	COG0505	Belongs to the CarA family
CDC35_RS07585	COG0484	heat shock protein binding
CDC35_RS07590	COG0443	Heat shock 70 kDa protein
CDC35_RS07595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDC35_RS07610	COG0129	dihydroxy-acid dehydratase activity
CDC35_RS07620	COG0303	'Molybdopterin
CDC35_RS07625	COG0335	large ribosomal subunit rRNA binding
CDC35_RS07635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDC35_RS07640	COG0250	Participates in transcription elongation, termination and antitermination
CDC35_RS07645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CDC35_RS07650	COG0081	regulation of translation
CDC35_RS07655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDC35_RS07660	COG0222	ribosome binding
CDC35_RS07695	COG0719	Fe-S assembly protein
CDC35_RS07710	COG2267	carboxylic ester hydrolase activity
CDC35_RS07725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDC35_RS07740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CDC35_RS07795	COG0739	heme binding
CDC35_RS07800	COG5002	protein histidine kinase activity
CDC35_RS07810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDC35_RS07825	COG0697	spore germination
CDC35_RS07830	COG0740	serine-type endopeptidase activity
CDC35_RS07835	COG0740	serine-type endopeptidase activity
CDC35_RS07840	COG1803	Methylglyoxal synthase
CDC35_RS07840	COG1597	lipid kinase activity
CDC35_RS07845	COG0009	L-threonylcarbamoyladenylate synthase
CDC35_RS07850	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CDC35_RS07855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC35_RS07865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDC35_RS07885	COG0601	transmembrane transport
CDC35_RS07890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC35_RS07900	COG0515	serine threonine protein kinase
CDC35_RS07900	COG3266	domain, Protein
CDC35_RS07930	COG2204	response regulator
CDC35_RS07945	COG0138	bifunctional purine biosynthesis protein purh
CDC35_RS07950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CDC35_RS07970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDC35_RS07975	COG2205	protein histidine kinase activity
CDC35_RS07980	COG1543	Belongs to the glycosyl hydrolase 57 family
CDC35_RS07995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDC35_RS08010	COG0656	L-ascorbic acid biosynthetic process
CDC35_RS08025	COG1420	regulation of RNA biosynthetic process
CDC35_RS08040	COG4974	Belongs to the 'phage' integrase family
CDC35_RS08045	COG3266	domain, Protein
CDC35_RS08045	COG0515	serine threonine protein kinase
CDC35_RS08050	COG3842	ATPase activity
CDC35_RS08055	COG0154	amidase activity
CDC35_RS08060	COG0596	Alpha beta hydrolase
CDC35_RS08070	COG1215	transferase activity, transferring glycosyl groups
CDC35_RS08110	COG0651	ATP synthesis coupled electron transport
CDC35_RS08125	COG0347	Belongs to the P(II) protein family
CDC35_RS08135	COG0475	glutathione-regulated potassium exporter activity
CDC35_RS08140	COG0330	HflC and HflK could
CDC35_RS08155	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC35_RS08175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CDC35_RS08180	COG2308	Evidence 4 Homologs of previously reported genes of
CDC35_RS08200	COG2329	Antibiotic biosynthesis monooxygenase
CDC35_RS08205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CDC35_RS08210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDC35_RS08245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CDC35_RS08265	COG0601	transmembrane transport
CDC35_RS08275	COG0157	Belongs to the NadC ModD family
CDC35_RS08300	COG3344	reverse transcriptase
CDC35_RS08345	COG1132	(ABC) transporter
CDC35_RS08360	COG3631	Ketosteroid isomerase-related protein
CDC35_RS08375	COG0753	catalase activity
CDC35_RS08390	COG0628	permease
CDC35_RS08395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CDC35_RS08410	COG5002	protein histidine kinase activity
CDC35_RS08425	COG0346	lactoylglutathione lyase activity
CDC35_RS08430	COG2211	Major facilitator Superfamily
CDC35_RS08435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDC35_RS08440	COG0803	Belongs to the bacterial solute-binding protein 9 family
CDC35_RS08445	COG1121	(ABC) transporter
CDC35_RS08455	COG4251	negative regulation of phosphorylation
CDC35_RS08455	COG5001	Diguanylate cyclase
CDC35_RS08455	COG2203	Gaf domain
CDC35_RS08455	COG3706	GGDEF domain
CDC35_RS08465	COG5002	protein histidine kinase activity
CDC35_RS08465	COG0784	Response regulator, receiver
CDC35_RS08480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDC35_RS08510	COG0724	RNA recognition motif
CDC35_RS08515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC35_RS08520	COG0583	DNA-binding transcription factor activity
CDC35_RS08525	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CDC35_RS08545	COG0643	Histidine kinase
CDC35_RS08545	COG2198	Histidine kinase
CDC35_RS08560	COG1252	NADH dehydrogenase
CDC35_RS08585	COG0628	permease
CDC35_RS08595	COG3265	gluconokinase activity
CDC35_RS08605	COG0587	DNA-directed DNA polymerase activity
CDC35_RS08625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC35_RS08625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC35_RS08635	COG0589	response to stress
CDC35_RS08640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC35_RS08655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC35_RS08655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC35_RS08680	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CDC35_RS08695	COG2091	lysine biosynthetic process via aminoadipic acid
CDC35_RS08720	COG0154	amidase activity
CDC35_RS08725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDC35_RS08730	COG0288	reversible hydration of carbon dioxide
CDC35_RS08735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS08745	COG1361	Conserved repeat domain
CDC35_RS08745	COG3266	domain, Protein
CDC35_RS08745	COG2911	Protein conserved in bacteria
CDC35_RS08750	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CDC35_RS08755	COG0644	oxidoreductase
CDC35_RS08770	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDC35_RS08790	COG0556	nucleotide-excision repair
CDC35_RS08800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CDC35_RS08810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CDC35_RS08815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CDC35_RS08825	COG0515	serine threonine protein kinase
CDC35_RS08845	COG1733	regulation of RNA biosynthetic process
CDC35_RS08855	COG1160	GTP binding
CDC35_RS08870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CDC35_RS08880	COG0667	Aldo Keto reductase
CDC35_RS08885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDC35_RS08890	COG1160	GTP binding
CDC35_RS08895	COG1480	7TM receptor with intracellular HD hydrolase
CDC35_RS08905	COG0393	Putative heavy-metal-binding
CDC35_RS08920	COG1333	cytochrome c biogenesis protein
CDC35_RS08925	COG4232	protein-disulfide reductase activity
CDC35_RS08935	COG0497	DNA recombination
CDC35_RS08945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC35_RS08955	COG1691	(AIR) carboxylase
CDC35_RS08970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CDC35_RS08975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC35_RS08980	COG0515	serine threonine protein kinase
CDC35_RS08995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDC35_RS09000	COG2267	carboxylic ester hydrolase activity
CDC35_RS09020	COG0525	valine-tRNA ligase activity
CDC35_RS09045	COG0511	ligase activity, forming carbon-carbon bonds
CDC35_RS09045	COG5016	pyruvate
CDC35_RS09065	COG0484	heat shock protein binding
CDC35_RS09070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDC35_RS09090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC35_RS09105	COG2052	Domain of unknown function (DUF370)
CDC35_RS09110	COG0194	GDP metabolic process
CDC35_RS09120	COG0740	serine-type endopeptidase activity
CDC35_RS09130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CDC35_RS09165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC35_RS09175	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CDC35_RS09215	COG0596	Alpha beta hydrolase
CDC35_RS09220	COG0604	alcohol dehydrogenase
CDC35_RS09220	COG3321	synthase
CDC35_RS09225	COG0300	oxidoreductase activity
CDC35_RS09245	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CDC35_RS09275	COG0406	alpha-ribazole phosphatase activity
CDC35_RS09330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDC35_RS09335	COG0573	inorganic phosphate transmembrane transporter activity
CDC35_RS09340	COG0581	inorganic phosphate transmembrane transporter activity
CDC35_RS09345	COG1620	l-lactate permease
CDC35_RS09355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDC35_RS09360	COG3264	Mechanosensitive ion channel
CDC35_RS09360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CDC35_RS09375	COG3344	reverse transcriptase
CDC35_RS09380	COG3210	domain, Protein
CDC35_RS09385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC35_RS09390	COG0725	ABC transporter, periplasmic molybdate-binding protein
CDC35_RS09395	COG1845	cytochrome c oxidase, subunit III
CDC35_RS09400	COG2226	methyltransferase
CDC35_RS09405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC35_RS09410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC35_RS09445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC35_RS09470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC35_RS09480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC35_RS09490	COG1196	nuclear chromosome segregation
CDC35_RS09490	COG0741	lytic transglycosylase activity
CDC35_RS09490	COG0739	heme binding
CDC35_RS09495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDC35_RS09505	COG1837	Belongs to the UPF0109 family
CDC35_RS09510	COG0228	four-way junction DNA binding
CDC35_RS09515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CDC35_RS09525	COG0625	glutathione transferase activity
CDC35_RS09530	COG1074	ATP-dependent DNA helicase activity
CDC35_RS09540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CDC35_RS09545	COG1017	nitric oxide dioxygenase activity
CDC35_RS09545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDC35_RS09550	COG1151	hydroxylamine reductase activity
CDC35_RS09560	COG2267	carboxylic ester hydrolase activity
CDC35_RS09565	COG0629	single-stranded DNA binding
CDC35_RS09570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDC35_RS09580	COG0495	leucyl-tRNA aminoacylation
CDC35_RS09590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDC35_RS09600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CDC35_RS09605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDC35_RS09610	COG1192	Involved in chromosome partitioning
CDC35_RS09615	COG2226	methyltransferase
CDC35_RS09620	COG0589	response to stress
CDC35_RS09625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC35_RS09625	COG0574	Belongs to the PEP-utilizing enzyme family
CDC35_RS09660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CDC35_RS09670	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CDC35_RS09690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CDC35_RS09700	COG0426	domain, Protein
CDC35_RS09700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC35_RS09705	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CDC35_RS09710	COG0716	FMN binding
CDC35_RS09725	COG0352	thiamine-phosphate diphosphorylase activity
CDC35_RS09755	COG1968	undecaprenyl-diphosphatase activity
CDC35_RS09770	COG2226	methyltransferase
CDC35_RS09775	COG0235	Class ii aldolase
CDC35_RS09780	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CDC35_RS09785	COG0181	hydroxymethylbilane synthase activity
CDC35_RS09800	COG0306	phosphate transporter
CDC35_RS09810	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDC35_RS09810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC35_RS09815	COG2199	diguanylate cyclase activity
CDC35_RS09815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CDC35_RS09820	COG0825	malonyl-CoA metabolic process
CDC35_RS09825	COG4221	oxidoreductase activity
CDC35_RS09830	COG0302	gtp cyclohydrolase
CDC35_RS09835	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CDC35_RS09840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDC35_RS09845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS09850	COG0839	Belongs to the complex I subunit 6 family
CDC35_RS09855	COG0713	ATP synthesis coupled electron transport
CDC35_RS09860	COG1361	Conserved repeat domain
CDC35_RS09875	COG2310	stress, protein
CDC35_RS09880	COG2310	stress, protein
CDC35_RS09885	COG1178	ABC-type Fe3 transport system permease component
CDC35_RS09890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CDC35_RS09915	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CDC35_RS09920	COG2010	Cytochrome c
CDC35_RS09925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CDC35_RS09930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC35_RS09935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CDC35_RS09950	COG1716	ATPase activity
CDC35_RS09960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDC35_RS09970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CDC35_RS09975	COG0088	Forms part of the polypeptide exit tunnel
CDC35_RS09980	COG0089	rRNA binding
CDC35_RS09985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CDC35_RS09990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDC35_RS09995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CDC35_RS10000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDC35_RS10005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CDC35_RS10010	COG0255	Belongs to the universal ribosomal protein uL29 family
CDC35_RS10015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CDC35_RS10020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDC35_RS10025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CDC35_RS10030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CDC35_RS10035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDC35_RS10040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDC35_RS10045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CDC35_RS10050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDC35_RS10055	COG0200	Binds to the 23S rRNA
CDC35_RS10060	COG0201	protein transport
CDC35_RS10065	COG0563	adenylate kinase activity
CDC35_RS10070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDC35_RS10075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CDC35_RS10080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CDC35_RS10085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CDC35_RS10090	COG0202	RNA polymerase activity
CDC35_RS10095	COG0203	ribosomal protein L17
CDC35_RS10100	COG0101	tRNA pseudouridine synthase activity
CDC35_RS10105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDC35_RS10110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDC35_RS10115	COG0254	rRNA binding
CDC35_RS10120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDC35_RS10135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CDC35_RS10145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC35_RS10150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDC35_RS10175	COG3411	Ferredoxin
CDC35_RS10200	COG1012	belongs to the aldehyde dehydrogenase family
CDC35_RS10205	COG2954	triphosphatase activity
CDC35_RS10215	COG1959	2 iron, 2 sulfur cluster binding
CDC35_RS10240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CDC35_RS10255	COG0557	exoribonuclease II activity
CDC35_RS10260	COG0312	modulator of DNA gyrase
CDC35_RS10270	COG0251	oxidation-reduction process
CDC35_RS10275	COG1575	Belongs to the MenA family. Type 1 subfamily
CDC35_RS10280	COG1169	isochorismate synthase
CDC35_RS10285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CDC35_RS10295	COG1773	rubredoxin
CDC35_RS10300	COG4447	cellulose binding
CDC35_RS10340	COG1295	ribonuclease BN
CDC35_RS10350	COG3344	reverse transcriptase
CDC35_RS10385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC35_RS10390	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CDC35_RS10425	COG0670	Belongs to the BI1 family
CDC35_RS10430	COG0426	domain, Protein
CDC35_RS10430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC35_RS10435	COG3022	response to hydroperoxide
CDC35_RS10470	COG2166	iron-sulfur cluster assembly
CDC35_RS10475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CDC35_RS10485	COG0484	heat shock protein binding
CDC35_RS10490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CDC35_RS10510	COG0582	viral genome integration into host DNA
CDC35_RS10525	COG2247	cell wall binding repeat
CDC35_RS10525	COG2385	sporulation resulting in formation of a cellular spore
CDC35_RS10530	COG2198	Histidine kinase
CDC35_RS10530	COG0643	Histidine kinase
CDC35_RS10530	COG0643	Histidine kinase
CDC35_RS10530	COG0784	Response regulator, receiver
CDC35_RS10530	COG2198	Histidine kinase
CDC35_RS10530	COG0784	Response regulator, receiver
CDC35_RS10535	COG0788	formyltetrahydrofolate deformylase activity
CDC35_RS10540	COG0542	response to heat
CDC35_RS10550	COG0019	diaminopimelate decarboxylase activity
CDC35_RS10555	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CDC35_RS10560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDC35_RS10565	COG4680	protein conserved in bacteria
CDC35_RS10585	COG3854	ATPases associated with a variety of cellular activities
CDC35_RS10610	COG3541	Predicted nucleotidyltransferase
CDC35_RS10620	COG0300	oxidoreductase activity
CDC35_RS10625	COG0454	-acetyltransferase
CDC35_RS10655	COG1834	amidinotransferase
CDC35_RS10680	COG0237	dephospho-CoA kinase activity
CDC35_RS10680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CDC35_RS10700	COG0772	Belongs to the SEDS family
CDC35_RS10705	COG4991	sh3 domain protein
CDC35_RS10705	COG0515	serine threonine protein kinase
CDC35_RS10705	COG3064	Membrane
CDC35_RS10710	COG0649	NAD binding
CDC35_RS10715	COG0285	dihydrofolate synthase activity
CDC35_RS10720	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CDC35_RS10730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDC35_RS10735	COG2154	pterin-4-alpha-carbinolamine dehydratase
CDC35_RS10745	COG0489	protein tyrosine kinase activity
CDC35_RS10770	COG4251	negative regulation of phosphorylation
CDC35_RS10775	COG0540	Belongs to the ATCase OTCase family
CDC35_RS10800	COG1131	(ABC) transporter
CDC35_RS10820	COG5499	transcription regulator containing HTH domain
CDC35_RS10840	COG0072	phenylalanine-tRNA ligase activity
CDC35_RS10840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC35_RS10850	COG0756	dUTP diphosphatase activity
CDC35_RS10860	COG0579	oxidoreductase
CDC35_RS10865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDC35_RS10870	COG0678	peroxiredoxin activity
CDC35_RS10875	COG0783	Belongs to the Dps family
CDC35_RS10885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC35_RS10890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS10895	COG2234	aminopeptidase activity
CDC35_RS10905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC35_RS10905	COG2022	thiamine diphosphate biosynthetic process
CDC35_RS10910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC35_RS10915	COG2223	nitrite transmembrane transporter activity
CDC35_RS10920	COG0243	molybdopterin cofactor binding
CDC35_RS10930	COG1473	amidohydrolase
CDC35_RS10935	COG0631	protein serine/threonine phosphatase activity
CDC35_RS10940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC35_RS10945	COG3937	granule-associated protein
CDC35_RS10960	COG1473	amidohydrolase
CDC35_RS10985	COG2340	Cysteine-rich secretory protein family
CDC35_RS11005	COG0584	glycerophosphoryl diester phosphodiesterase
CDC35_RS11015	COG0463	Glycosyl transferase, family 2
CDC35_RS11030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CDC35_RS11035	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC35_RS11045	COG2319	Wd-40 repeat
CDC35_RS11045	COG3903	Transcriptional regulator
CDC35_RS11060	COG0730	response to heat
CDC35_RS11090	COG1192	Involved in chromosome partitioning
CDC35_RS11100	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CDC35_RS11125	COG3659	wide pore channel activity
CDC35_RS11130	COG1132	(ABC) transporter
CDC35_RS11135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC35_RS11140	COG0017	Asparaginyl-tRNA synthetase
CDC35_RS11150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CDC35_RS11160	COG1702	phosphate starvation-inducible protein PhoH
CDC35_RS11170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CDC35_RS11175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CDC35_RS11180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDC35_RS11185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDC35_RS11200	COG0750	zinc metalloprotease
CDC35_RS11205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDC35_RS11210	COG2124	cytochrome p450
CDC35_RS11215	COG0531	amino acid
CDC35_RS11220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC35_RS11225	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CDC35_RS11265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC35_RS11270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC35_RS11275	COG2203	Gaf domain
CDC35_RS11275	COG5001	Diguanylate cyclase
CDC35_RS11275	COG4251	negative regulation of phosphorylation
CDC35_RS11275	COG3706	GGDEF domain
CDC35_RS11280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDC35_RS11285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CDC35_RS11285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CDC35_RS11295	COG0708	Exodeoxyribonuclease III
CDC35_RS11330	COG0339	signal peptide processing
CDC35_RS11340	COG5001	Diguanylate cyclase
CDC35_RS11340	COG3706	GGDEF domain
CDC35_RS11340	COG4251	negative regulation of phosphorylation
CDC35_RS11340	COG2203	Gaf domain
CDC35_RS11360	COG1253	flavin adenine dinucleotide binding
CDC35_RS11375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDC35_RS11380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDC35_RS11400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC35_RS11420	COG0537	adenosine 5'-monophosphoramidase activity
CDC35_RS11425	COG0848	biopolymer transport protein
CDC35_RS11430	COG0811	peptide transport
CDC35_RS11440	COG0552	protein localization to endoplasmic reticulum
CDC35_RS11445	COG2208	phosphoserine phosphatase activity
CDC35_RS11455	COG0165	Argininosuccinate lyase
CDC35_RS11465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CDC35_RS11465	COG0517	IMP dehydrogenase activity
CDC35_RS11465	COG0617	tRNA 3'-terminal CCA addition
CDC35_RS11485	COG4581	dead DEAH box helicase
CDC35_RS11515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CDC35_RS11515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDC35_RS11520	COG1280	lysine exporter protein (LysE YggA)
CDC35_RS11530	COG0668	transmembrane transport
CDC35_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
CDC35_RS11555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC35_RS11590	COG0445	tRNA wobble uridine modification
CDC35_RS11615	COG1131	(ABC) transporter
CDC35_RS11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC35_RS11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC35_RS11630	COG0842	Transport permease protein
CDC35_RS11630	COG1129	ABC transporter
CDC35_RS11635	COG0842	Transport permease protein
CDC35_RS11655	COG2205	protein histidine kinase activity
CDC35_RS11655	COG2198	Histidine kinase
CDC35_RS11655	COG0784	Response regulator, receiver
CDC35_RS11670	COG0217	transcriptional regulatory protein
CDC35_RS11675	COG0613	PHP domain protein
CDC35_RS11680	COG0837	glucose binding
CDC35_RS11690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CDC35_RS11710	COG1472	Belongs to the glycosyl hydrolase 3 family
CDC35_RS11715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDC35_RS11720	COG0583	DNA-binding transcription factor activity
CDC35_RS11730	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CDC35_RS11740	COG0297	glycogen (starch) synthase activity
CDC35_RS11745	COG0745	RESPONSE REGULATOR receiver
CDC35_RS11750	COG0604	alcohol dehydrogenase
CDC35_RS11755	COG1408	metallophosphoesterase
CDC35_RS11770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDC35_RS11775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDC35_RS11805	COG0287	Prephenate dehydrogenase
CDC35_RS11810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CDC35_RS11815	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CDC35_RS11830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC35_RS11875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDC35_RS11970	COG0312	modulator of DNA gyrase
CDC35_RS11975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDC35_RS11985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CDC35_RS11990	COG1494	fructose-1,6-bisphosphatase
CDC35_RS12005	COG0351	phosphomethylpyrimidine kinase
CDC35_RS12010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CDC35_RS12020	COG0793	Belongs to the peptidase S41A family
CDC35_RS12030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDC35_RS12035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDC35_RS12075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CDC35_RS12085	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CDC35_RS12090	COG0745	RESPONSE REGULATOR receiver
CDC35_RS12105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC35_RS12115	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS12135	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS12145	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS12150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CDC35_RS12155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDC35_RS12185	COG0436	Aminotransferase
CDC35_RS12205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CDC35_RS12215	COG0006	proline dipeptidase activity
CDC35_RS12220	COG1515	deoxyribonuclease V activity
CDC35_RS12235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS12240	COG1254	Belongs to the acylphosphatase family
CDC35_RS12250	COG0768	penicillin binding
CDC35_RS12270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC35_RS12290	COG1715	Restriction endonuclease
CDC35_RS12295	COG0646	methionine synthase
CDC35_RS12295	COG1410	methionine synthase
CDC35_RS12315	COG0156	8-amino-7-oxononanoate synthase activity
CDC35_RS12330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDC35_RS12335	COG1234	tRNA 3'-trailer cleavage
CDC35_RS12350	COG1077	Cell shape determining protein MreB Mrl
CDC35_RS12365	COG1819	glycosyl
CDC35_RS12370	COG3128	pkhd-type hydroxylase
CDC35_RS12380	COG0180	Tryptophanyl-tRNA synthetase
CDC35_RS12390	COG0395	ABC-type sugar transport system, permease component
CDC35_RS12405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC35_RS12420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CDC35_RS12455	COG1413	lyase activity
CDC35_RS12480	COG1027	Aspartate ammonia-lyase
CDC35_RS12485	COG0804	urea catabolic process
CDC35_RS12495	COG0724	RNA recognition motif
CDC35_RS12500	COG0052	Belongs to the universal ribosomal protein uS2 family
CDC35_RS12505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CDC35_RS12525	COG0415	Belongs to the DNA photolyase family
CDC35_RS12540	COG0612	Peptidase, M16
CDC35_RS12545	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CDC35_RS12555	COG0134	indole-3-glycerol-phosphate synthase activity
CDC35_RS12560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC35_RS12565	COG3956	TIGRFAM MazG family protein
CDC35_RS12580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDC35_RS12590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC35_RS12605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDC35_RS12615	COG1640	4-alpha-glucanotransferase
CDC35_RS12650	COG0539	negative regulation of cytoplasmic translation
CDC35_RS12655	COG0412	Dienelactone hydrolase
CDC35_RS12660	COG0131	Imidazoleglycerol-phosphate dehydratase
CDC35_RS12665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CDC35_RS12670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC35_RS12675	COG4372	Transposase
CDC35_RS12690	COG2201	protein-glutamate methylesterase activity
CDC35_RS12705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CDC35_RS12750	COG0728	peptidoglycan biosynthetic process
CDC35_RS12755	COG0037	tRNA processing
CDC35_RS12760	COG1595	DNA-templated transcription, initiation
CDC35_RS12800	COG3063	Type IV pilus biogenesis stability protein PilW
CDC35_RS12845	COG0571	ribonuclease III activity
CDC35_RS12850	COG0672	)-iron permease
CDC35_RS12870	COG0459	protein refolding
CDC35_RS12880	COG0644	oxidoreductase
CDC35_RS12885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDC35_RS12900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDC35_RS12925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC35_RS12950	COG0515	serine threonine protein kinase
CDC35_RS12950	COG3266	domain, Protein
CDC35_RS12980	COG0392	lysyltransferase activity
CDC35_RS12990	COG0628	permease
CDC35_RS13015	COG4401	Chorismate mutase type I
CDC35_RS13020	COG1132	(ABC) transporter
CDC35_RS13025	COG0745	RESPONSE REGULATOR receiver
CDC35_RS13035	COG0840	transmembrane signaling receptor activity
CDC35_RS13045	COG2201	protein-glutamate methylesterase activity
CDC35_RS13050	COG2201	protein-glutamate methylesterase activity
CDC35_RS13055	COG1185	polyribonucleotide nucleotidyltransferase activity
CDC35_RS13090	COG1858	cytochrome C peroxidase
CDC35_RS13100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CDC35_RS13105	COG1054	Belongs to the UPF0176 family
CDC35_RS13110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CDC35_RS13115	COG3842	ATPase activity
CDC35_RS13125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC35_RS13135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CDC35_RS13145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CDC35_RS13150	COG2197	response regulator
CDC35_RS13160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CDC35_RS13175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC35_RS13195	COG0569	domain protein
CDC35_RS13200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CDC35_RS13205	COG1216	Glycosyl transferase, family 2
CDC35_RS13205	COG0463	Glycosyl transferase, family 2
CDC35_RS13215	COG0037	tRNA processing
CDC35_RS13230	COG1218	3'(2'),5'-bisphosphate nucleotidase
CDC35_RS13260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CDC35_RS13265	COG0643	Histidine kinase
CDC35_RS13265	COG0784	Response regulator, receiver
CDC35_RS13265	COG2198	Histidine kinase
CDC35_RS13270	COG2203	Gaf domain
CDC35_RS13270	COG0840	transmembrane signaling receptor activity
CDC35_RS13280	COG0745	RESPONSE REGULATOR receiver
CDC35_RS13285	COG0784	Response regulator, receiver
CDC35_RS13290	COG0784	Response regulator, receiver
CDC35_RS13300	COG5001	Diguanylate cyclase
CDC35_RS13300	COG4251	negative regulation of phosphorylation
CDC35_RS13300	COG3706	GGDEF domain
CDC35_RS13300	COG2203	Gaf domain
CDC35_RS13310	COG2188	Transcriptional regulator
CDC35_RS13325	COG0811	peptide transport
CDC35_RS13330	COG0848	biopolymer transport protein
CDC35_RS13350	COG0316	Belongs to the HesB IscA family
CDC35_RS13370	COG0859	PFAM glycosyl transferase family 9
CDC35_RS13375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CDC35_RS13390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDC35_RS13410	COG0395	ABC-type sugar transport system, permease component
CDC35_RS13420	COG4106	trans-aconitate 2-methyltransferase activity
CDC35_RS13425	COG0668	transmembrane transport
CDC35_RS13430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDC35_RS13435	COG0033	Phosphoglucomutase
CDC35_RS13440	COG1881	PFAM PEBP family protein
CDC35_RS13480	COG4251	negative regulation of phosphorylation
CDC35_RS13485	COG1166	arginine decarboxylase activity
CDC35_RS13490	COG0191	fructose-bisphosphate aldolase activity
CDC35_RS13525	COG0463	Glycosyl transferase, family 2
CDC35_RS13570	COG0424	maF-like protein
CDC35_RS13575	COG0006	proline dipeptidase activity
CDC35_RS13585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CDC35_RS13590	COG1950	PFAM Membrane protein of
CDC35_RS13605	COG0237	dephospho-CoA kinase activity
CDC35_RS13615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC35_RS13620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDC35_RS13625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC35_RS13635	COG0426	domain, Protein
CDC35_RS13635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC35_RS13645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC35_RS13645	COG0426	domain, Protein
CDC35_RS13655	COG0512	Glutamine amidotransferase of anthranilate synthase
CDC35_RS13660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CDC35_RS13665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDC35_RS13675	COG0170	dolichyl monophosphate biosynthetic process
CDC35_RS13680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDC35_RS13685	COG0482	sulfurtransferase activity
CDC35_RS13700	COG1215	transferase activity, transferring glycosyl groups
CDC35_RS13705	COG3000	fatty acid hydroxylase
CDC35_RS13705	COG0300	oxidoreductase activity
CDC35_RS13745	COG0737	Belongs to the 5'-nucleotidase family
CDC35_RS13750	COG0450	alkyl hydroperoxide reductase
CDC35_RS13760	COG1836	PFAM Integral membrane protein DUF92
CDC35_RS13770	COG5001	Diguanylate cyclase
CDC35_RS13770	COG3300	MHYT domain
CDC35_RS13780	COG1366	Belongs to the anti-sigma-factor antagonist family
CDC35_RS13790	COG2217	Heavy metal translocating P-type atpase
CDC35_RS13810	COG0463	Glycosyl transferase, family 2
CDC35_RS13825	COG2124	cytochrome p450
CDC35_RS13830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDC35_RS13835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDC35_RS13845	COG4585	Histidine kinase
CDC35_RS13850	COG2197	response regulator
CDC35_RS13855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CDC35_RS13865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS13870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDC35_RS13875	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CDC35_RS13880	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CDC35_RS13885	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CDC35_RS13890	COG4451	ribulose bisphosphate carboxylase, small
CDC35_RS13890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDC35_RS13895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDC35_RS13900	COG1850	ribulose-bisphosphate carboxylase activity
CDC35_RS13910	COG4451	ribulose bisphosphate carboxylase, small
CDC35_RS13915	COG0107	imidazoleglycerol-phosphate synthase activity
CDC35_RS13960	COG3258	Cytochrome c
CDC35_RS13965	COG0723	plastoquinol--plastocyanin reductase activity
CDC35_RS13975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CDC35_RS13980	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CDC35_RS13980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC35_RS13985	COG1562	ergosterol biosynthetic process
CDC35_RS14000	COG4399	Belongs to the UPF0754 family
CDC35_RS14005	COG2226	methyltransferase
CDC35_RS14045	COG3842	ATPase activity
CDC35_RS14065	COG1555	photosystem II stabilization
CDC35_RS14070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDC35_RS14090	COG0681	Belongs to the peptidase S26 family
CDC35_RS14095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDC35_RS14105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CDC35_RS14110	COG1981	membrane
CDC35_RS14120	COG2205	protein histidine kinase activity
CDC35_RS14120	COG2198	Histidine kinase
CDC35_RS14120	COG0784	Response regulator, receiver
CDC35_RS14130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDC35_RS14145	COG2062	phosphohistidine phosphatase, SixA
CDC35_RS14165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDC35_RS14170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CDC35_RS14175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDC35_RS14180	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS14185	COG3210	domain, Protein
CDC35_RS14200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CDC35_RS14220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDC35_RS14235	COG0514	ATP-dependent DNA helicase (RecQ)
CDC35_RS14265	COG0321	lipoyl(octanoyl) transferase activity
CDC35_RS14270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CDC35_RS14280	COG1459	type II secretion system
CDC35_RS14290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CDC35_RS14295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CDC35_RS14300	COG0443	Heat shock 70 kDa protein
CDC35_RS14305	COG0484	heat shock protein binding
CDC35_RS14315	COG1162	GTPase activity
CDC35_RS14325	COG4956	integral membrane protein (PIN domain superfamily)
CDC35_RS14330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDC35_RS14335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDC35_RS14345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC35_RS14350	COG0783	Belongs to the Dps family
CDC35_RS14370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC35_RS14390	COG0723	plastoquinol--plastocyanin reductase activity
CDC35_RS14405	COG0516	GMP reductase activity
CDC35_RS14420	COG0135	phosphoribosylanthranilate isomerase activity
CDC35_RS14425	COG0151	Belongs to the GarS family
CDC35_RS14430	COG5002	protein histidine kinase activity
CDC35_RS14440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC35_RS14450	COG0066	3-isopropylmalate dehydratase activity
CDC35_RS14480	COG0515	serine threonine protein kinase
CDC35_RS14490	COG0538	isocitrate dehydrogenase activity
CDC35_RS14495	COG0515	serine threonine protein kinase
CDC35_RS14525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CDC35_RS14535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CDC35_RS14550	COG5002	protein histidine kinase activity
CDC35_RS14555	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDC35_RS14560	COG0271	Belongs to the BolA IbaG family
CDC35_RS14565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CDC35_RS14570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC35_RS14575	COG0443	Heat shock 70 kDa protein
CDC35_RS14585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC35_RS14610	COG0371	Dehydrogenase
CDC35_RS14620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC35_RS14635	COG2885	chlorophyll binding
CDC35_RS14640	COG2885	chlorophyll binding
CDC35_RS14645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC35_RS14655	COG0492	ferredoxin-NADP+ reductase activity
CDC35_RS14685	COG1215	transferase activity, transferring glycosyl groups
CDC35_RS14695	COG1615	UPF0182 protein
CDC35_RS14700	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS14700	COG1216	Glycosyl transferase, family 2
CDC35_RS14730	COG1442	glycosyl transferase family 8
CDC35_RS14730	COG1216	Glycosyl transferase, family 2
CDC35_RS14750	COG1091	dTDP-4-dehydrorhamnose reductase activity
CDC35_RS14765	COG0328	RNA-DNA hybrid ribonuclease activity
CDC35_RS14790	COG0861	Integral membrane protein TerC family
CDC35_RS14795	COG0523	cobalamin synthesis protein
CDC35_RS14800	COG1490	D-aminoacyl-tRNA deacylase activity
CDC35_RS14805	COG0023	Translation Initiation Factor
CDC35_RS14810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDC35_RS14815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CDC35_RS14820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDC35_RS14825	COG0681	Belongs to the peptidase S26 family
CDC35_RS14840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDC35_RS14845	COG0572	uridine kinase
CDC35_RS14855	COG0215	cysteine-tRNA ligase activity
CDC35_RS14860	COG3344	reverse transcriptase
CDC35_RS14870	COG2084	Dehydrogenase
CDC35_RS14880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDC35_RS14895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CDC35_RS14910	COG1191	sigma factor activity
CDC35_RS14925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC35_RS14930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDC35_RS14970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDC35_RS14990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDC35_RS14995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDC35_RS15000	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CDC35_RS15005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDC35_RS15010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CDC35_RS15020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDC35_RS15025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDC35_RS15040	COG0579	oxidoreductase
CDC35_RS15045	COG1773	rubredoxin
CDC35_RS15075	COG0336	Belongs to the RNA methyltransferase TrmD family
CDC35_RS15085	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDC35_RS15085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDC35_RS15095	COG0210	DNA helicase
CDC35_RS15110	COG2203	Gaf domain
CDC35_RS15110	COG4251	negative regulation of phosphorylation
CDC35_RS15110	COG5001	Diguanylate cyclase
CDC35_RS15110	COG3706	GGDEF domain
CDC35_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
CDC35_RS15130	COG0471	metal ion transport
CDC35_RS15130	COG3273	potassium ion transport
CDC35_RS15135	COG0475	glutathione-regulated potassium exporter activity
CDC35_RS15135	COG0589	response to stress
CDC35_RS15145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CDC35_RS15155	COG3264	Mechanosensitive ion channel
CDC35_RS15155	COG1196	nuclear chromosome segregation
CDC35_RS15165	COG0745	RESPONSE REGULATOR receiver
CDC35_RS15185	COG1803	Methylglyoxal synthase
CDC35_RS15185	COG1597	lipid kinase activity
CDC35_RS15205	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CDC35_RS15210	COG0489	protein tyrosine kinase activity
CDC35_RS15215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDC35_RS15220	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS15225	COG1131	(ABC) transporter
CDC35_RS15230	COG0109	protoheme IX farnesyltransferase activity
CDC35_RS15240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC35_RS15245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC35_RS15250	COG1845	cytochrome c oxidase, subunit III
CDC35_RS15290	COG0745	RESPONSE REGULATOR receiver
CDC35_RS15340	COG1468	defense response to virus
CDC35_RS15340	COG1518	maintenance of DNA repeat elements
CDC35_RS15385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CDC35_RS15390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC35_RS15400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CDC35_RS15415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDC35_RS15420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CDC35_RS15425	COG0745	RESPONSE REGULATOR receiver
CDC35_RS15430	COG5002	protein histidine kinase activity
CDC35_RS15460	COG3266	domain, Protein
CDC35_RS15460	COG0515	serine threonine protein kinase
CDC35_RS15465	COG0406	alpha-ribazole phosphatase activity
CDC35_RS15475	COG3237	CsbD-like
CDC35_RS15495	COG0501	Belongs to the peptidase M48B family
CDC35_RS15510	COG0668	transmembrane transport
CDC35_RS15535	COG0745	RESPONSE REGULATOR receiver
CDC35_RS15540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC35_RS15550	COG0095	Lipoate-protein ligase
CDC35_RS15580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC35_RS15595	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CDC35_RS15605	COG2183	response to ionizing radiation
CDC35_RS15620	COG0025	NhaP-type Na H and K H
CDC35_RS15625	COG2912	Transglutaminase-like superfamily
CDC35_RS15630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CDC35_RS15635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CDC35_RS15655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CDC35_RS15660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDC35_RS15685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDC35_RS15695	COG1132	(ABC) transporter
CDC35_RS15710	COG1002	Type II restriction enzyme, methylase subunits
CDC35_RS15720	COG2081	HI0933 family
CDC35_RS15725	COG0300	oxidoreductase activity
CDC35_RS15745	COG0275	rRNA processing
CDC35_RS15760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CDC35_RS15780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDC35_RS15790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CDC35_RS15795	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC35_RS15795	COG0022	dehydrogenase e1 component
CDC35_RS15800	COG0312	modulator of DNA gyrase
CDC35_RS15805	COG0475	glutathione-regulated potassium exporter activity
CDC35_RS15815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDC35_RS15820	COG0142	geranyltranstransferase activity
CDC35_RS15825	COG0515	serine threonine protein kinase
CDC35_RS15825	COG1357	PFAM Pentapeptide repeats (8 copies)
CDC35_RS15830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CDC35_RS15840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDC35_RS15845	COG4636	protein conserved in cyanobacteria
CDC35_RS15850	COG0312	modulator of DNA gyrase
CDC35_RS15860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDC35_RS15885	COG0640	Transcriptional regulator
CDC35_RS15895	COG5002	protein histidine kinase activity
CDC35_RS15900	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC35_RS15915	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CDC35_RS15920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDC35_RS15940	COG4948	Mandelate Racemase Muconate Lactonizing
CDC35_RS15950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CDC35_RS15955	COG1007	ATP synthesis coupled electron transport
CDC35_RS15960	COG1754	DNA topoisomerase type I activity
CDC35_RS15960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDC35_RS15965	COG0745	RESPONSE REGULATOR receiver
CDC35_RS15970	COG0469	pyruvate kinase activity
CDC35_RS16000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CDC35_RS16005	COG0564	pseudouridine synthase activity
CDC35_RS16015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CDC35_RS16030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CDC35_RS16035	COG0628	permease
CDC35_RS16040	COG0166	Belongs to the GPI family
CDC35_RS16045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDC35_RS16055	COG0121	glutamine amidotransferase
CDC35_RS16060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDC35_RS16075	COG1413	lyase activity
CDC35_RS16120	COG0515	serine threonine protein kinase
CDC35_RS16160	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CDC35_RS16160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDC35_RS16165	COG1316	TRANSCRIPTIONal
CDC35_RS16175	COG0746	molybdenum cofactor guanylyltransferase activity
CDC35_RS16180	COG0772	Belongs to the SEDS family
CDC35_RS16190	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CDC35_RS16200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC35_RS16225	COG0175	sulfate reduction
CDC35_RS16240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC35_RS16250	COG0363	glucosamine-6-phosphate deaminase activity
CDC35_RS16260	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CDC35_RS16270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CDC35_RS16275	COG0513	Belongs to the DEAD box helicase family
CDC35_RS16280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC35_RS16285	COG0434	BtpA family
CDC35_RS16290	COG4243	Vitamin k epoxide reductase
CDC35_RS16300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDC35_RS16305	COG4178	(ABC) transporter
CDC35_RS16310	COG0189	ligase activity
CDC35_RS16315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDC35_RS16325	COG0024	Methionine aminopeptidase
CDC35_RS16330	COG2264	protein methyltransferase activity
CDC35_RS16340	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
CDC35_RS16360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDC35_RS16370	COG0018	arginyl-trna synthetase
CDC35_RS16375	COG0747	negative chemotaxis
CDC35_RS16385	COG0673	inositol 2-dehydrogenase activity
CDC35_RS16400	COG2197	response regulator
CDC35_RS16410	COG0004	ammonium transporteR
CDC35_RS16415	COG0314	molybdopterin synthase activity
CDC35_RS16420	COG0784	Response regulator, receiver
CDC35_RS16420	COG5002	protein histidine kinase activity
CDC35_RS16430	COG1028	Short-chain dehydrogenase reductase Sdr
CDC35_RS16445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CDC35_RS16450	COG0589	response to stress
CDC35_RS16455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC35_RS16460	COG0398	Pfam SNARE associated Golgi protein
CDC35_RS16465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDC35_RS16480	COG3170	Tfp pilus assembly protein FimV
CDC35_RS16480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CDC35_RS16490	COG0195	Participates in both transcription termination and antitermination
CDC35_RS16495	COG0779	Required for maturation of 30S ribosomal subunits
CDC35_RS16500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CDC35_RS16505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CDC35_RS16510	COG0793	Belongs to the peptidase S41A family
CDC35_RS16530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CDC35_RS16540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CDC35_RS16545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDC35_RS16550	COG0557	exoribonuclease II activity
CDC35_RS16560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CDC35_RS16570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CDC35_RS16575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDC35_RS16580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDC35_RS16585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CDC35_RS16590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CDC35_RS16595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDC35_RS16600	COG0356	it plays a direct role in the translocation of protons across the membrane
CDC35_RS16615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDC35_RS16655	COG4251	negative regulation of phosphorylation
CDC35_RS16655	COG5001	Diguanylate cyclase
CDC35_RS16655	COG2203	Gaf domain
CDC35_RS16655	COG3706	GGDEF domain
CDC35_RS16660	COG0673	inositol 2-dehydrogenase activity
CDC35_RS16665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDC35_RS16670	COG2816	NAD+ diphosphatase activity
CDC35_RS16695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDC35_RS16700	COG0121	glutamine amidotransferase
CDC35_RS16805	COG1187	pseudouridine synthase activity
CDC35_RS16815	COG1022	Amp-dependent synthetase and ligase
CDC35_RS16835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC35_RS16840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDC35_RS16855	COG3320	Male sterility
CDC35_RS16855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC35_RS16865	COG0295	cytidine deaminase activity
CDC35_RS16870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDC35_RS16875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC35_RS16890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CDC35_RS16915	COG1278	Cold shock
CDC35_RS16925	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS16930	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS16935	COG1132	(ABC) transporter
CDC35_RS16945	COG3659	wide pore channel activity
CDC35_RS16955	COG0484	heat shock protein binding
CDC35_RS16960	COG0196	riboflavin kinase activity
CDC35_RS16980	COG0473	3-isopropylmalate dehydrogenase activity
CDC35_RS16995	COG0392	lysyltransferase activity
CDC35_RS17000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC35_RS17000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDC35_RS17010	COG3468	outer membrane autotransporter barrel domain protein
CDC35_RS17025	COG0419	ATPase involved in DNA repair
CDC35_RS17030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDC35_RS17055	COG0857	belongs to the CobB CobQ family
CDC35_RS17060	COG3210	domain, Protein
CDC35_RS17065	COG0459	protein refolding
CDC35_RS17070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CDC35_RS17080	COG0277	FAD linked oxidase domain protein
CDC35_RS17100	COG1070	Carbohydrate kinase
CDC35_RS17105	COG0745	RESPONSE REGULATOR receiver
CDC35_RS17110	COG5398	heme oxygenase
CDC35_RS17120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CDC35_RS17140	COG4572	Cation transport regulator
CDC35_RS17145	COG1295	ribonuclease BN
CDC35_RS17160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CDC35_RS17185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CDC35_RS17190	COG0083	homoserine kinase activity
CDC35_RS17200	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CDC35_RS17205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDC35_RS17210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDC35_RS17220	COG1489	DNA binding
CDC35_RS17235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CDC35_RS17240	COG3408	Glycogen debranching enzyme
CDC35_RS17240	COG3119	arylsulfatase activity
CDC35_RS17245	COG3408	Glycogen debranching enzyme
CDC35_RS17245	COG3119	arylsulfatase activity
CDC35_RS17265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC35_RS17270	COG0735	belongs to the Fur family
CDC35_RS17325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CDC35_RS17335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC35_RS17345	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CDC35_RS17350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CDC35_RS17355	COG0740	serine-type endopeptidase activity
CDC35_RS17360	COG0544	peptidyl-prolyl cis-trans isomerase activity
CDC35_RS17365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CDC35_RS17370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC35_RS17375	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CDC35_RS17385	COG0527	aspartate kinase activity
CDC35_RS17390	COG1357	PFAM Pentapeptide repeats (8 copies)
CDC35_RS17390	COG0515	serine threonine protein kinase
CDC35_RS17395	COG0004	ammonium transporteR
CDC35_RS17410	COG0616	signal peptide processing
CDC35_RS17475	COG5002	protein histidine kinase activity
CDC35_RS17480	COG0745	RESPONSE REGULATOR receiver
CDC35_RS17505	COG3266	domain, Protein
CDC35_RS17505	COG0515	serine threonine protein kinase
CDC35_RS17515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CDC35_RS17535	COG1615	UPF0182 protein
CDC35_RS17560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDC35_RS17575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDC35_RS17600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDC35_RS17615	COG2319	Wd-40 repeat
CDC35_RS17615	COG4249	Peptidase C14 caspase catalytic subunit p20
CDC35_RS17620	COG0745	RESPONSE REGULATOR receiver
CDC35_RS17650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CDC35_RS17655	COG0539	negative regulation of cytoplasmic translation
CDC35_RS17665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDC35_RS17670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC35_RS17675	COG0671	phosphoesterase, PA-phosphatase related
CDC35_RS17680	COG0483	inositol monophosphate 1-phosphatase activity
CDC35_RS17695	COG0784	Response regulator, receiver
CDC35_RS17700	COG2197	response regulator
CDC35_RS17705	COG4251	negative regulation of phosphorylation
CDC35_RS17710	COG0784	Response regulator, receiver
CDC35_RS17715	COG2205	protein histidine kinase activity
CDC35_RS17715	COG2202	Pas domain
CDC35_RS17720	COG2205	protein histidine kinase activity
CDC35_RS17725	COG1053	succinate dehydrogenase
CDC35_RS17735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDC35_RS17740	COG2244	polysaccharide biosynthetic process
CDC35_RS17760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC35_RS17775	COG0163	prenyltransferase activity
CDC35_RS17785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDC35_RS17825	COG2154	pterin-4-alpha-carbinolamine dehydratase
CDC35_RS17830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDC35_RS17840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS17845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS17850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC35_RS17860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CDC35_RS17865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDC35_RS17875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC35_RS17875	COG0574	Belongs to the PEP-utilizing enzyme family
CDC35_RS17910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CDC35_RS17915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDC35_RS17920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CDC35_RS17930	COG2197	response regulator
CDC35_RS17935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDC35_RS17945	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CDC35_RS17950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDC35_RS17955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC35_RS17970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CDC35_RS17975	COG2119	membrane
CDC35_RS17980	COG2119	membrane
CDC35_RS17985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDC35_RS17985	COG0758	DNA mediated transformation
CDC35_RS18000	COG0515	serine threonine protein kinase
CDC35_RS18005	COG1160	GTP binding
CDC35_RS18020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC35_RS18025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC35_RS18030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDC35_RS18040	COG0429	hydrolase of the alpha beta-hydrolase fold
CDC35_RS18055	COG0596	Alpha beta hydrolase
CDC35_RS18060	COG2205	protein histidine kinase activity
CDC35_RS18070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDC35_RS18075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CDC35_RS18085	COG0668	transmembrane transport
CDC35_RS18100	COG0412	Dienelactone hydrolase
CDC35_RS18120	COG0067	glutamate synthase
CDC35_RS18120	COG0069	glutamate synthase activity
CDC35_RS18120	COG0070	glutamate synthase
CDC35_RS18125	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CDC35_RS18125	COG0662	Cupin 2, conserved barrel domain protein
CDC35_RS18130	COG0316	Belongs to the HesB IscA family
CDC35_RS18135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDC35_RS18140	COG0049	tRNA binding
CDC35_RS18145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDC35_RS18150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDC35_RS18155	COG0051	transcription antitermination factor activity, RNA binding
CDC35_RS18160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CDC35_RS18170	COG0077	Prephenate dehydratase
CDC35_RS18170	COG1605	Chorismate mutase
CDC35_RS18180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDC35_RS18185	COG1530	ribonuclease E activity
CDC35_RS18190	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC35_RS18200	COG2046	Belongs to the sulfate adenylyltransferase family
CDC35_RS18205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDC35_RS18210	COG3064	Membrane
CDC35_RS18210	COG0515	serine threonine protein kinase
CDC35_RS18210	COG4991	sh3 domain protein
CDC35_RS18215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC35_RS18220	COG1132	(ABC) transporter
CDC35_RS18250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CDC35_RS18270	COG0662	Cupin 2, conserved barrel domain protein
CDC35_RS18270	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CDC35_RS18275	COG1324	tolerance protein
CDC35_RS18295	COG3688	RNA-binding protein containing a PIN domain
CDC35_RS18315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDC35_RS18320	COG0745	RESPONSE REGULATOR receiver
CDC35_RS18335	COG1058	Belongs to the CinA family
CDC35_RS18335	COG1546	Belongs to the CinA family
CDC35_RS18340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDC35_RS18345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDC35_RS18360	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDC35_RS18365	COG0360	Binds together with S18 to 16S ribosomal RNA
CDC35_RS18370	COG3217	Mosc domain protein beta barrel domain protein
CDC35_RS18370	COG0633	Ferredoxin
CDC35_RS18375	COG0602	queuosine metabolic process
CDC35_RS18380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDC35_RS18400	COG1032	radical SAM domain protein
CDC35_RS18435	COG0297	glycogen (starch) synthase activity
CDC35_RS18445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDC35_RS18445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDC35_RS18455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC35_RS18460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC35_RS18465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC35_RS18465	COG1116	anion transmembrane transporter activity
CDC35_RS18470	COG1116	anion transmembrane transporter activity
CDC35_RS18485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC35_RS18485	COG1116	anion transmembrane transporter activity
CDC35_RS18490	COG1116	anion transmembrane transporter activity
CDC35_RS18500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CDC35_RS18505	COG0475	glutathione-regulated potassium exporter activity
CDC35_RS18515	COG0598	Magnesium transport protein CorA
CDC35_RS18525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CDC35_RS18530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CDC35_RS18535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CDC35_RS18540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CDC35_RS18560	COG0140	phosphoribosyl-ATP diphosphatase activity
CDC35_RS18560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDC35_RS18570	COG1127	ABC transporter
CDC35_RS18575	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CDC35_RS18580	COG0515	serine threonine protein kinase
CDC35_RS18585	COG0583	DNA-binding transcription factor activity
CDC35_RS18595	COG3118	belongs to the thioredoxin family
CDC35_RS18600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC35_RS18630	COG0745	RESPONSE REGULATOR receiver
CDC35_RS18635	COG1131	(ABC) transporter
CDC35_RS18635	COG1716	ATPase activity
CDC35_RS18635	COG0842	Transport permease protein
CDC35_RS18640	COG0587	DNA-directed DNA polymerase activity
CDC35_RS18645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDC35_RS18655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC35_RS18715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDC35_RS18720	COG1132	(ABC) transporter
CDC35_RS18735	COG3046	protein related to deoxyribodipyrimidine photolyase
CDC35_RS18745	COG0193	aminoacyl-tRNA hydrolase activity
CDC35_RS18750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CDC35_RS18760	COG3344	reverse transcriptase
CDC35_RS18765	COG1088	dTDP-glucose 4,6-dehydratase activity
CDC35_RS18775	COG0463	Glycosyl transferase, family 2
CDC35_RS18785	COG0438	transferase activity, transferring glycosyl groups
CDC35_RS18785	COG1216	Glycosyl transferase, family 2
CDC35_RS18790	COG3063	Type IV pilus biogenesis stability protein PilW
CDC35_RS18800	COG0481	GTPase activity
CDC35_RS18810	COG2205	protein histidine kinase activity
CDC35_RS18810	COG2202	Pas domain
CDC35_RS18815	COG1045	serine acetyltransferase
CDC35_RS18820	COG0484	heat shock protein binding
CDC35_RS18830	COG0850	regulation of cytokinetic process
CDC35_RS18835	COG2894	cell division
CDC35_RS18840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDC35_RS18845	COG1215	transferase activity, transferring glycosyl groups
CDC35_RS18855	COG0577	efflux transmembrane transporter activity
CDC35_RS18855	COG1136	(ABC) transporter
CDC35_RS18880	COG3210	domain, Protein
CDC35_RS18895	COG0116	Belongs to the methyltransferase superfamily
CDC35_RS18905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDC35_RS18910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDC35_RS18920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CDC35_RS18925	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CDC35_RS18930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDC35_RS18930	COG0519	Catalyzes the synthesis of GMP from XMP
CDC35_RS18935	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CDC35_RS18935	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CDC35_RS18945	COG1404	Belongs to the peptidase S8 family
CDC35_RS18950	COG0359	binds to the 23S rRNA
CDC35_RS18960	COG1446	asparaginase
CDC35_RS18965	COG0167	dihydroorotate dehydrogenase activity
CDC35_RS18970	COG1217	gtp-binding protein TYPA
CDC35_RS18975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDC35_RS18980	COG1971	Probably functions as a manganese efflux pump
CDC35_RS19005	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CDC35_RS19010	COG0408	coproporphyrinogen oxidase activity
CDC35_RS19015	COG5398	heme oxygenase
CDC35_RS19025	COG1233	COG1233 Phytoene dehydrogenase and related
CDC35_RS19065	COG0714	Associated with various cellular activities
CDC35_RS19125	COG0831	urea catabolic process
CDC35_RS19130	COG0832	Belongs to the urease beta subunit family
CDC35_RS19135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDC35_RS19140	COG0829	nickel cation binding
CDC35_RS19170	COG0673	inositol 2-dehydrogenase activity
CDC35_RS19180	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CDC35_RS19215	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDC35_RS19240	COG0440	acetolactate synthase activity
CDC35_RS19255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC35_RS19285	COG3118	belongs to the thioredoxin family
CDC35_RS19305	COG3103	Sh3 type 3 domain protein
CDC35_RS19305	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDC35_RS19305	COG4991	sh3 domain protein
CDC35_RS19310	COG1840	ABC-type Fe3 transport system, periplasmic component
CDC35_RS19315	COG0752	glycyl-tRNA synthetase alpha subunit
CDC35_RS19350	COG2217	Heavy metal translocating P-type atpase
CDC35_RS19380	COG1566	PFAM secretion protein HlyD family protein
CDC35_RS19390	COG1136	(ABC) transporter
CDC35_RS19390	COG4591	ABC-type transport system involved in lipoprotein release permease component
CDC35_RS19415	COG2226	methyltransferase
CDC35_RS19425	COG2132	Multicopper oxidase
CDC35_RS19430	COG0789	Transcriptional regulator
CDC35_RS19450	COG2217	Heavy metal translocating P-type atpase
CDC35_RS19465	COG3344	reverse transcriptase
CDC35_RS19480	COG0640	Transcriptional regulator
CDC35_RS19485	COG2217	Heavy metal translocating P-type atpase
CDC35_RS19490	COG4243	Vitamin k epoxide reductase
CDC35_RS19515	COG2226	methyltransferase
CDC35_RS19550	COG4974	Belongs to the 'phage' integrase family
CDC35_RS19590	COG4474	Belongs to the UPF0398 family
CDC35_RS19670	COG3657	addiction module killer protein
CDC35_RS19680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC35_RS19685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC35_RS19685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC35_RS19745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CDC35_RS19750	COG1595	DNA-templated transcription, initiation
CDC35_RS19775	COG1192	Involved in chromosome partitioning
CDC35_RS19810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CDC35_RS19820	COG1573	uracil-dna glycosylase
CDC35_RS19930	COG0723	plastoquinol--plastocyanin reductase activity
CDC35_RS19935	COG1592	Rubrerythrin
CDC35_RS19940	COG0288	reversible hydration of carbon dioxide
CDC35_RS19950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CDC35_RS19965	COG5002	protein histidine kinase activity
CDC35_RS20050	COG5002	protein histidine kinase activity
CDC35_RS20055	COG0745	RESPONSE REGULATOR receiver
CDC35_RS20070	COG0745	RESPONSE REGULATOR receiver
CDC35_RS20075	COG5002	protein histidine kinase activity
CDC35_RS20125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDC35_RS20135	COG0716	FMN binding
CDC35_RS20235	COG2201	protein-glutamate methylesterase activity
CDC35_RS20370	COG4085	toxin activity
CDC35_RS20370	COG0737	Belongs to the 5'-nucleotidase family
CDC35_RS20370	COG1525	nuclease
CDC35_RS20415	COG0126	phosphoglycerate kinase activity
CDC35_RS20430	COG1475	DNA binding
CDC35_RS20455	COG1754	DNA topoisomerase type I activity
CDC35_RS20455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDC35_RS20470	COG0582	viral genome integration into host DNA
CDC35_RS20485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC35_RS20540	COG2205	protein histidine kinase activity
CDC35_RS20615	COG2831	hemolysin activation secretion protein
CDC35_RS20620	COG2197	response regulator
CDC35_RS20645	COG0515	serine threonine protein kinase
CDC35_RS20645	COG2815	serine threonine protein kinase
CDC35_RS20680	COG2124	cytochrome p450
CDC35_RS20845	COG0716	FMN binding
CDC35_RS20885	COG2132	Multicopper oxidase
CDC35_RS20890	COG2217	Heavy metal translocating P-type atpase
CDC35_RS20895	COG0789	Transcriptional regulator
CDC35_RS20910	COG2217	Heavy metal translocating P-type atpase
CDC35_RS20920	COG2226	methyltransferase
CDC35_RS20925	COG0640	Transcriptional regulator
CDC35_RS20930	COG2217	Heavy metal translocating P-type atpase
CDC35_RS20935	COG4243	Vitamin k epoxide reductase
CDC35_RS20940	COG1742	UPF0060 membrane protein
CDC35_RS20955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CDC35_RS20985	COG5002	protein histidine kinase activity
CDC35_RS20990	COG0745	RESPONSE REGULATOR receiver
CDC35_RS21020	COG2132	Multicopper oxidase
CDC35_RS21040	COG2132	Multicopper oxidase
CDC35_RS21110	COG4974	Belongs to the 'phage' integrase family
CDC35_RS21120	COG1278	Cold shock
CDC35_RS21130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDC35_RS21240	COG0724	RNA recognition motif
CDC35_RS21250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDC35_RS21260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CDC35_RS21275	COG1192	Involved in chromosome partitioning
CDC35_RS21360	COG2161	toxin-antitoxin pair type II binding
CDC35_RS21365	COG4115	mRNA cleavage
CDC35_RS21430	COG4974	Belongs to the 'phage' integrase family
CDC35_RS21465	COG2361	Protein of unknown function DUF86
CDC35_RS21575	COG1061	Type III restriction enzyme res subunit
CDC35_RS21580	COG0322	excinuclease ABC activity
CDC35_RS21635	COG1309	transcriptional regulator
CDC35_RS21785	COG0489	protein tyrosine kinase activity