locus-tag	class	description
CMC5_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CMC5_RS00015	COG0443	Heat shock 70 kDa protein
CMC5_RS00020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CMC5_RS00030	COG2217	Heavy metal translocating P-type atpase
CMC5_RS00050	COG1420	regulation of RNA biosynthetic process
CMC5_RS00055	COG0564	pseudouridine synthase activity
CMC5_RS00060	COG0745	RESPONSE REGULATOR receiver
CMC5_RS00065	COG0525	valine-tRNA ligase activity
CMC5_RS00085	COG0515	serine threonine protein kinase
CMC5_RS00085	COG2815	serine threonine protein kinase
CMC5_RS00105	COG0113	porphobilinogen synthase activity
CMC5_RS00120	COG4941	Belongs to the sigma-70 factor family
CMC5_RS00140	COG1132	(ABC) transporter
CMC5_RS00145	COG1132	(ABC) transporter
CMC5_RS00160	COG0515	serine threonine protein kinase
CMC5_RS00180	COG0776	regulation of translation
CMC5_RS00185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CMC5_RS00190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CMC5_RS00195	COG0653	protein targeting
CMC5_RS00210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CMC5_RS00230	COG0412	Dienelactone hydrolase
CMC5_RS00245	COG0402	S-adenosylhomocysteine deaminase activity
CMC5_RS00260	COG0434	BtpA family
CMC5_RS00275	COG0436	Aminotransferase
CMC5_RS00305	COG0656	L-ascorbic acid biosynthetic process
CMC5_RS00335	COG0633	Ferredoxin
CMC5_RS00335	COG3217	Mosc domain protein beta barrel domain protein
CMC5_RS00350	COG0444	Belongs to the ABC transporter superfamily
CMC5_RS00360	COG0673	inositol 2-dehydrogenase activity
CMC5_RS00390	COG2239	Acts as a magnesium transporter
CMC5_RS00420	COG0631	protein serine/threonine phosphatase activity
CMC5_RS00430	COG3757	hydrolase, family 25
CMC5_RS00435	COG0443	Heat shock 70 kDa protein
CMC5_RS00460	COG0183	Belongs to the thiolase family
CMC5_RS00465	COG1024	Enoyl-CoA hydratase
CMC5_RS00500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CMC5_RS00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CMC5_RS00535	COG0720	synthase
CMC5_RS00560	COG0745	RESPONSE REGULATOR receiver
CMC5_RS00570	COG2239	Acts as a magnesium transporter
CMC5_RS00575	COG0629	single-stranded DNA binding
CMC5_RS00590	COG0776	regulation of translation
CMC5_RS00595	COG1215	transferase activity, transferring glycosyl groups
CMC5_RS00650	COG0297	glycogen (starch) synthase activity
CMC5_RS00660	COG1477	protein flavinylation
CMC5_RS00670	COG3228	Belongs to the MtfA family
CMC5_RS00735	COG2204	response regulator
CMC5_RS00750	COG1175	transmembrane transport
CMC5_RS00770	COG0515	serine threonine protein kinase
CMC5_RS00810	COG4935	Belongs to the peptidase S8 family
CMC5_RS00810	COG1404	Belongs to the peptidase S8 family
CMC5_RS00820	COG2814	Major facilitator Superfamily
CMC5_RS00845	COG3318	Belongs to the UPF0149 family
CMC5_RS00845	COG3012	SEC-C Motif Domain Protein
CMC5_RS00850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS00870	COG1024	Enoyl-CoA hydratase
CMC5_RS00875	COG4221	oxidoreductase activity
CMC5_RS00890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CMC5_RS00890	COG0646	methionine synthase
CMC5_RS00900	COG2272	Belongs to the type-B carboxylesterase lipase family
CMC5_RS00905	COG2124	cytochrome p450
CMC5_RS00905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CMC5_RS00915	COG4974	Belongs to the 'phage' integrase family
CMC5_RS00920	COG3119	arylsulfatase activity
CMC5_RS00950	COG0714	Associated with various cellular activities
CMC5_RS00985	COG0788	formyltetrahydrofolate deformylase activity
CMC5_RS01000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CMC5_RS01015	COG0531	amino acid
CMC5_RS01020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CMC5_RS01060	COG0456	acetyltransferase
CMC5_RS01060	COG1214	PFAM Peptidase M22, glycoprotease
CMC5_RS01070	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS01100	COG2353	YceI-like domain
CMC5_RS01115	COG2353	YceI-like domain
CMC5_RS01155	COG2815	serine threonine protein kinase
CMC5_RS01155	COG0515	serine threonine protein kinase
CMC5_RS01165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS01170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CMC5_RS01190	COG5002	protein histidine kinase activity
CMC5_RS01190	COG0784	Response regulator, receiver
CMC5_RS01225	COG3876	Protein conserved in bacteria
CMC5_RS01245	COG0631	protein serine/threonine phosphatase activity
CMC5_RS01255	COG1595	DNA-templated transcription, initiation
CMC5_RS01285	COG0625	glutathione transferase activity
CMC5_RS01290	COG2205	protein histidine kinase activity
CMC5_RS01315	COG1597	lipid kinase activity
CMC5_RS01320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CMC5_RS01325	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS01345	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CMC5_RS01370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CMC5_RS01420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CMC5_RS01425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CMC5_RS01480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CMC5_RS01485	COG3047	cAMP biosynthetic process
CMC5_RS01485	COG2885	chlorophyll binding
CMC5_RS01520	COG0701	Predicted permease
CMC5_RS01530	COG0640	Transcriptional regulator
CMC5_RS01535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CMC5_RS01535	COG2022	thiamine diphosphate biosynthetic process
CMC5_RS01605	COG0835	chemotaxis
CMC5_RS01610	COG0840	transmembrane signaling receptor activity
CMC5_RS01620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CMC5_RS01625	COG2201	protein-glutamate methylesterase activity
CMC5_RS01630	COG5002	protein histidine kinase activity
CMC5_RS01640	COG0751	glycine-tRNA ligase activity
CMC5_RS01650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CMC5_RS01655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CMC5_RS01665	COG0515	serine threonine protein kinase
CMC5_RS01665	COG2815	serine threonine protein kinase
CMC5_RS01730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CMC5_RS01740	COG0463	Glycosyl transferase, family 2
CMC5_RS01745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CMC5_RS01755	COG0793	Belongs to the peptidase S41A family
CMC5_RS01760	COG1595	DNA-templated transcription, initiation
CMC5_RS01775	COG0268	Binds directly to 16S ribosomal RNA
CMC5_RS01780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CMC5_RS01780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CMC5_RS01785	COG0750	zinc metalloprotease
CMC5_RS01810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CMC5_RS01830	COG3483	tryptophan 2,3-dioxygenase activity
CMC5_RS01850	COG1696	Membrane protein involved in D-alanine export
CMC5_RS01860	COG0726	polysaccharide deacetylase
CMC5_RS01885	COG4191	Histidine kinase
CMC5_RS01920	COG0616	signal peptide processing
CMC5_RS01925	COG1136	(ABC) transporter
CMC5_RS01935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CMC5_RS01965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CMC5_RS01975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CMC5_RS01980	COG0658	competence protein
CMC5_RS01980	COG2333	competence protein COMEC
CMC5_RS02015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CMC5_RS02020	COG1053	succinate dehydrogenase
CMC5_RS02025	COG2009	succinate dehydrogenase
CMC5_RS02045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CMC5_RS02060	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CMC5_RS02065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CMC5_RS02070	COG1480	7TM receptor with intracellular HD hydrolase
CMC5_RS02075	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS02095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CMC5_RS02120	COG1573	uracil-dna glycosylase
CMC5_RS02125	COG0492	ferredoxin-NADP+ reductase activity
CMC5_RS02145	COG0659	secondary active sulfate transmembrane transporter activity
CMC5_RS02150	COG0288	reversible hydration of carbon dioxide
CMC5_RS02160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CMC5_RS02160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CMC5_RS02170	COG0137	argininosuccinate synthase activity
CMC5_RS02205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CMC5_RS02210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CMC5_RS02220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CMC5_RS02290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CMC5_RS02330	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS02395	COG1408	metallophosphoesterase
CMC5_RS02400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CMC5_RS02420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CMC5_RS02425	COG0737	Belongs to the 5'-nucleotidase family
CMC5_RS02455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CMC5_RS02465	COG4676	Protein conserved in bacteria
CMC5_RS02470	COG1192	Involved in chromosome partitioning
CMC5_RS02500	COG0515	serine threonine protein kinase
CMC5_RS02510	COG0802	atpase or kinase
CMC5_RS02545	COG1309	transcriptional regulator
CMC5_RS02550	COG0243	molybdopterin cofactor binding
CMC5_RS02555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CMC5_RS02560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CMC5_RS02565	COG0697	spore germination
CMC5_RS02575	COG0589	response to stress
CMC5_RS02595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CMC5_RS02605	COG2135	peptidase activity
CMC5_RS02625	COG0745	RESPONSE REGULATOR receiver
CMC5_RS02630	COG0473	3-isopropylmalate dehydrogenase activity
CMC5_RS02650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CMC5_RS02675	COG0156	8-amino-7-oxononanoate synthase activity
CMC5_RS02680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CMC5_RS02690	COG1136	(ABC) transporter
CMC5_RS02705	COG0592	DNA-directed DNA polymerase activity
CMC5_RS02710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMC5_RS02715	COG0187	DNA topoisomerase II activity
CMC5_RS02720	COG0542	response to heat
CMC5_RS02750	COG1138	Cytochrome C-type biogenesis protein
CMC5_RS02755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CMC5_RS02760	COG0183	Belongs to the thiolase family
CMC5_RS02800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CMC5_RS02805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CMC5_RS02825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS02830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CMC5_RS02830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CMC5_RS02835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CMC5_RS02905	COG1755	Isoprenylcysteine carboxyl methyltransferase
CMC5_RS02915	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS02960	COG0745	RESPONSE REGULATOR receiver
CMC5_RS02970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CMC5_RS02980	COG1305	Transglutaminase-like
CMC5_RS02990	COG0714	Associated with various cellular activities
CMC5_RS03015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CMC5_RS03060	COG0405	Gamma-glutamyltransferase
CMC5_RS03070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CMC5_RS03115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CMC5_RS03135	COG0534	Mate efflux family protein
CMC5_RS03200	COG1450	Type ii and iii secretion system protein
CMC5_RS03255	COG1067	ATP-dependent peptidase activity
CMC5_RS03265	COG2197	response regulator
CMC5_RS03275	COG0596	Alpha beta hydrolase
CMC5_RS03325	COG0515	serine threonine protein kinase
CMC5_RS03325	COG2815	serine threonine protein kinase
CMC5_RS03335	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS03340	COG1396	sequence-specific DNA binding
CMC5_RS03355	COG0252	asparaginase activity
CMC5_RS03365	COG3047	cAMP biosynthetic process
CMC5_RS03365	COG2885	chlorophyll binding
CMC5_RS03390	COG3293	Transposase
CMC5_RS03400	COG0628	permease
CMC5_RS03405	COG2204	response regulator
CMC5_RS03480	COG1388	LysM domain
CMC5_RS03480	COG3942	CHAP domain
CMC5_RS03485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CMC5_RS03495	COG0515	serine threonine protein kinase
CMC5_RS03500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CMC5_RS03510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CMC5_RS03515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CMC5_RS03595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CMC5_RS03600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CMC5_RS03605	COG0356	it plays a direct role in the translocation of protons across the membrane
CMC5_RS03615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CMC5_RS03620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CMC5_RS03635	COG2177	Part of the ABC transporter FtsEX involved in
CMC5_RS03640	COG2884	Cell division ATP-binding protein ftsE
CMC5_RS03645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CMC5_RS03690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CMC5_RS03695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CMC5_RS03700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CMC5_RS03705	COG0255	Belongs to the universal ribosomal protein uL29 family
CMC5_RS03710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CMC5_RS03715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CMC5_RS03720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CMC5_RS03725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CMC5_RS03730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CMC5_RS03735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CMC5_RS03740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CMC5_RS03745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CMC5_RS03750	COG0200	Binds to the 23S rRNA
CMC5_RS03755	COG0201	protein transport
CMC5_RS03765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CMC5_RS03770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CMC5_RS03775	COG0202	RNA polymerase activity
CMC5_RS03780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CMC5_RS03785	COG4191	Histidine kinase
CMC5_RS03795	COG4191	Histidine kinase
CMC5_RS03800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CMC5_RS03825	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS03830	COG0494	nUDIX hydrolase
CMC5_RS03835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CMC5_RS03850	COG0384	phenazine biosynthesis protein PhzF
CMC5_RS03860	COG0484	heat shock protein binding
CMC5_RS03875	COG1022	Amp-dependent synthetase and ligase
CMC5_RS03885	COG2815	serine threonine protein kinase
CMC5_RS03885	COG0515	serine threonine protein kinase
CMC5_RS03915	COG0616	signal peptide processing
CMC5_RS03940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CMC5_RS03945	COG2224	Isocitrate lyase
CMC5_RS03955	COG2815	serine threonine protein kinase
CMC5_RS03955	COG0515	serine threonine protein kinase
CMC5_RS03960	COG0586	Pfam SNARE associated Golgi protein
CMC5_RS03965	COG4603	Belongs to the binding-protein-dependent transport system permease family
CMC5_RS03970	COG1079	Belongs to the binding-protein-dependent transport system permease family
CMC5_RS03975	COG3845	ABC transporter
CMC5_RS04020	COG2124	cytochrome p450
CMC5_RS04025	COG1309	transcriptional regulator
CMC5_RS04040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CMC5_RS04095	COG1459	type II secretion system
CMC5_RS04120	COG2204	response regulator
CMC5_RS04165	COG2375	cellular response to nickel ion
CMC5_RS04165	COG1132	(ABC) transporter
CMC5_RS04195	COG1595	DNA-templated transcription, initiation
CMC5_RS04200	COG0659	secondary active sulfate transmembrane transporter activity
CMC5_RS04205	COG3002	Belongs to the UPF0753 family
CMC5_RS04210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CMC5_RS04315	COG1505	serine-type exopeptidase activity
CMC5_RS04325	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CMC5_RS04350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CMC5_RS04355	COG1032	radical SAM domain protein
CMC5_RS04365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CMC5_RS04370	COG0101	tRNA pseudouridine synthase activity
CMC5_RS04380	COG0742	ribosomal rna small subunit methyltransferase
CMC5_RS04405	COG2890	protein-(glutamine-N5) methyltransferase activity
CMC5_RS04430	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS04455	COG5000	phosphorelay sensor kinase activity
CMC5_RS04500	COG5002	protein histidine kinase activity
CMC5_RS04500	COG2205	protein histidine kinase activity
CMC5_RS04500	COG0784	Response regulator, receiver
CMC5_RS04505	COG0596	Alpha beta hydrolase
CMC5_RS04530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CMC5_RS04540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CMC5_RS04550	COG1408	metallophosphoesterase
CMC5_RS04560	COG0673	inositol 2-dehydrogenase activity
CMC5_RS04565	COG0825	malonyl-CoA metabolic process
CMC5_RS04575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CMC5_RS04600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CMC5_RS04610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CMC5_RS04625	COG3852	Histidine kinase
CMC5_RS04665	COG3973	AAA domain
CMC5_RS04700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CMC5_RS04705	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CMC5_RS04730	COG0443	Heat shock 70 kDa protein
CMC5_RS04735	COG3781	membrane
CMC5_RS04740	COG1271	oxidase subunit
CMC5_RS04805	COG1842	Phage shock protein A
CMC5_RS04810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CMC5_RS04810	COG0574	Belongs to the PEP-utilizing enzyme family
CMC5_RS04815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMC5_RS04835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CMC5_RS04835	COG0515	serine threonine protein kinase
CMC5_RS04840	COG4249	Peptidase C14 caspase catalytic subunit p20
CMC5_RS04840	COG2319	Wd-40 repeat
CMC5_RS04850	COG1309	transcriptional regulator
CMC5_RS04890	COG2843	Capsule synthesis protein
CMC5_RS04895	COG0745	RESPONSE REGULATOR receiver
CMC5_RS04915	COG2124	cytochrome p450
CMC5_RS04930	COG1858	cytochrome C peroxidase
CMC5_RS04950	COG2208	phosphoserine phosphatase activity
CMC5_RS04985	COG0515	serine threonine protein kinase
CMC5_RS05025	COG2205	protein histidine kinase activity
CMC5_RS05030	COG5002	protein histidine kinase activity
CMC5_RS05030	COG2198	Histidine kinase
CMC5_RS05030	COG0784	Response regulator, receiver
CMC5_RS05050	COG0515	serine threonine protein kinase
CMC5_RS05050	COG2815	serine threonine protein kinase
CMC5_RS05060	COG1595	DNA-templated transcription, initiation
CMC5_RS05065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CMC5_RS05100	COG0671	phosphoesterase, PA-phosphatase related
CMC5_RS05110	COG1297	OPT oligopeptide transporter protein
CMC5_RS05180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CMC5_RS05200	COG0357	Ribosomal RNA small subunit methyltransferase G
CMC5_RS05225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CMC5_RS05245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS05285	COG0557	exoribonuclease II activity
CMC5_RS05295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS05300	COG0515	serine threonine protein kinase
CMC5_RS05320	COG0515	serine threonine protein kinase
CMC5_RS05335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CMC5_RS05340	COG1428	Deoxynucleoside kinase
CMC5_RS05380	COG3590	peptidase
CMC5_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS05410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CMC5_RS05420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CMC5_RS05440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CMC5_RS05450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CMC5_RS05460	COG3842	ATPase activity
CMC5_RS05490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CMC5_RS05495	COG0302	gtp cyclohydrolase
CMC5_RS05500	COG1177	transmembrane transport
CMC5_RS05505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CMC5_RS05515	COG3842	ATPase activity
CMC5_RS05525	COG0303	'Molybdopterin
CMC5_RS05570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CMC5_RS05585	COG2937	Belongs to the GPAT DAPAT family
CMC5_RS05665	COG1285	pathogenesis
CMC5_RS05695	COG2234	aminopeptidase activity
CMC5_RS05725	COG1940	carbohydrate kinase activity
CMC5_RS05735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CMC5_RS05740	COG0045	succinate-CoA ligase (ADP-forming) activity
CMC5_RS05755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CMC5_RS05785	COG4771	TonB-dependent receptor
CMC5_RS05800	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CMC5_RS05805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CMC5_RS05810	COG1177	transmembrane transport
CMC5_RS05815	COG1176	ABC-type spermidine putrescine transport system, permease component I
CMC5_RS05820	COG3842	ATPase activity
CMC5_RS05825	COG0515	serine threonine protein kinase
CMC5_RS05825	COG2815	serine threonine protein kinase
CMC5_RS05840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CMC5_RS05855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CMC5_RS05865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CMC5_RS05880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CMC5_RS05900	COG3591	Belongs to the peptidase S1B family
CMC5_RS05905	COG0495	leucyl-tRNA aminoacylation
CMC5_RS05925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CMC5_RS05935	COG0631	protein serine/threonine phosphatase activity
CMC5_RS05940	COG0242	peptide deformylase activity
CMC5_RS05970	COG0515	serine threonine protein kinase
CMC5_RS05970	COG2815	serine threonine protein kinase
CMC5_RS05985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CMC5_RS05990	COG5000	phosphorelay sensor kinase activity
CMC5_RS05995	COG0516	GMP reductase activity
CMC5_RS05995	COG0517	IMP dehydrogenase activity
CMC5_RS06020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CMC5_RS06025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CMC5_RS06030	COG0739	heme binding
CMC5_RS06030	COG1196	nuclear chromosome segregation
CMC5_RS06030	COG0741	lytic transglycosylase activity
CMC5_RS06050	COG0515	serine threonine protein kinase
CMC5_RS06055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CMC5_RS06060	COG2720	vancomycin resistance protein
CMC5_RS06075	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS06080	COG3848	Pyruvate phosphate dikinase
CMC5_RS06080	COG0574	Belongs to the PEP-utilizing enzyme family
CMC5_RS06090	COG0217	transcriptional regulatory protein
CMC5_RS06095	COG0475	glutathione-regulated potassium exporter activity
CMC5_RS06125	COG4104	PAAR repeat-containing protein
CMC5_RS06130	COG0004	ammonium transporteR
CMC5_RS06145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS06150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CMC5_RS06160	COG0463	Glycosyl transferase, family 2
CMC5_RS06190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CMC5_RS06205	COG0463	Glycosyl transferase, family 2
CMC5_RS06235	COG4208	sulfate ABC transporter
CMC5_RS06240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CMC5_RS06260	COG2204	response regulator
CMC5_RS06305	COG0714	Associated with various cellular activities
CMC5_RS06315	COG0842	Transport permease protein
CMC5_RS06315	COG1129	ABC transporter
CMC5_RS06325	COG2815	serine threonine protein kinase
CMC5_RS06325	COG0515	serine threonine protein kinase
CMC5_RS06375	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CMC5_RS06400	COG0793	Belongs to the peptidase S41A family
CMC5_RS06425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CMC5_RS06440	COG0515	serine threonine protein kinase
CMC5_RS06450	COG0515	serine threonine protein kinase
CMC5_RS06450	COG2815	serine threonine protein kinase
CMC5_RS06485	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
CMC5_RS06510	COG0752	glycyl-tRNA synthetase alpha subunit
CMC5_RS06520	COG2816	NAD+ diphosphatase activity
CMC5_RS06525	COG1233	COG1233 Phytoene dehydrogenase and related
CMC5_RS06545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CMC5_RS06550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS06555	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS06565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CMC5_RS06570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CMC5_RS06600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CMC5_RS06605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CMC5_RS06615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CMC5_RS06615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CMC5_RS06625	COG0339	signal peptide processing
CMC5_RS06635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CMC5_RS06640	COG0588	phosphoglycerate mutase activity
CMC5_RS06670	COG0631	protein serine/threonine phosphatase activity
CMC5_RS06690	COG0312	modulator of DNA gyrase
CMC5_RS06695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CMC5_RS06720	COG2011	ABC-type metal ion transport system permease component
CMC5_RS06795	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS06800	COG0515	serine threonine protein kinase
CMC5_RS06800	COG2815	serine threonine protein kinase
CMC5_RS06805	COG1253	flavin adenine dinucleotide binding
CMC5_RS06835	COG0366	Alpha amylase catalytic
CMC5_RS06845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CMC5_RS06855	COG2205	protein histidine kinase activity
CMC5_RS06865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CMC5_RS06870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CMC5_RS06875	COG3158	transport of potassium into the cell
CMC5_RS06880	COG1404	Belongs to the peptidase S8 family
CMC5_RS06885	COG1404	Belongs to the peptidase S8 family
CMC5_RS06935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CMC5_RS06970	COG0513	Belongs to the DEAD box helicase family
CMC5_RS06975	COG2175	clavaminate synthase activity
CMC5_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS07005	COG2040	homocysteine
CMC5_RS07020	COG0625	glutathione transferase activity
CMC5_RS07030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CMC5_RS07040	COG0427	acetyl-CoA hydrolase
CMC5_RS07080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CMC5_RS07085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CMC5_RS07095	COG0071	Belongs to the small heat shock protein (HSP20) family
CMC5_RS07110	COG1233	COG1233 Phytoene dehydrogenase and related
CMC5_RS07115	COG1562	ergosterol biosynthetic process
CMC5_RS07150	COG0142	geranyltranstransferase activity
CMC5_RS07155	COG5002	protein histidine kinase activity
CMC5_RS07175	COG0776	regulation of translation
CMC5_RS07180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CMC5_RS07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS07205	COG4191	Histidine kinase
CMC5_RS07225	COG0515	serine threonine protein kinase
CMC5_RS07280	COG3973	AAA domain
CMC5_RS07305	COG1181	Belongs to the D-alanine--D-alanine ligase family
CMC5_RS07345	COG0183	Belongs to the thiolase family
CMC5_RS07360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CMC5_RS07365	COG0616	signal peptide processing
CMC5_RS07370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CMC5_RS07385	COG5002	protein histidine kinase activity
CMC5_RS07390	COG1100	Small GTP-binding protein
CMC5_RS07435	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS07485	COG0515	serine threonine protein kinase
CMC5_RS07485	COG2815	serine threonine protein kinase
CMC5_RS07530	COG1648	precorrin-2 dehydrogenase activity
CMC5_RS07530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CMC5_RS07555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CMC5_RS07600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CMC5_RS07610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CMC5_RS07620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CMC5_RS07625	COG0081	regulation of translation
CMC5_RS07630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CMC5_RS07635	COG0222	ribosome binding
CMC5_RS07640	COG0085	RNA polymerase activity
CMC5_RS07645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CMC5_RS07660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CMC5_RS07675	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS07685	COG1595	DNA-templated transcription, initiation
CMC5_RS07700	COG0515	serine threonine protein kinase
CMC5_RS07705	COG2815	serine threonine protein kinase
CMC5_RS07705	COG0515	serine threonine protein kinase
CMC5_RS07710	COG0515	serine threonine protein kinase
CMC5_RS07710	COG2815	serine threonine protein kinase
CMC5_RS07730	COG2885	chlorophyll binding
CMC5_RS07770	COG1946	Acyl-CoA thioesterase
CMC5_RS07805	COG3781	membrane
CMC5_RS07810	COG0693	protein deglycase activity
CMC5_RS07815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS07825	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CMC5_RS07840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CMC5_RS07870	COG0463	Glycosyl transferase, family 2
CMC5_RS07870	COG0457	Tetratricopeptide repeat
CMC5_RS07880	COG0745	RESPONSE REGULATOR receiver
CMC5_RS07885	COG1562	ergosterol biosynthetic process
CMC5_RS07915	COG3437	response regulator, receiver
CMC5_RS07915	COG4999	Histidine kinase
CMC5_RS07915	COG2205	protein histidine kinase activity
CMC5_RS07915	COG3850	Histidine kinase
CMC5_RS07960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CMC5_RS07980	COG0205	6-phosphofructokinase activity
CMC5_RS07990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMC5_RS08015	COG0515	serine threonine protein kinase
CMC5_RS08015	COG2815	serine threonine protein kinase
CMC5_RS08055	COG0783	Belongs to the Dps family
CMC5_RS08065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CMC5_RS08065	COG2885	chlorophyll binding
CMC5_RS08110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CMC5_RS08110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CMC5_RS08120	COG1216	Glycosyl transferase, family 2
CMC5_RS08125	COG3118	belongs to the thioredoxin family
CMC5_RS08140	COG0149	triose-phosphate isomerase activity
CMC5_RS08145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CMC5_RS08165	COG1653	transport
CMC5_RS08175	COG0395	ABC-type sugar transport system, permease component
CMC5_RS08185	COG0443	Heat shock 70 kDa protein
CMC5_RS08190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CMC5_RS08195	COG0316	Belongs to the HesB IscA family
CMC5_RS08205	COG1104	cysteine desulfurase activity
CMC5_RS08240	COG2271	Major facilitator Superfamily
CMC5_RS08265	COG2130	NADP-dependent
CMC5_RS08275	COG2391	methyltransferase activity
CMC5_RS08310	COG0625	glutathione transferase activity
CMC5_RS08345	COG0489	protein tyrosine kinase activity
CMC5_RS08345	COG3206	protein involved in exopolysaccharide biosynthesis
CMC5_RS08375	COG0367	asparagine synthase
CMC5_RS08380	COG2124	cytochrome p450
CMC5_RS08385	COG2124	cytochrome p450
CMC5_RS08405	COG0443	Heat shock 70 kDa protein
CMC5_RS08445	COG1136	(ABC) transporter
CMC5_RS08445	COG0577	efflux transmembrane transporter activity
CMC5_RS08455	COG1136	(ABC) transporter
CMC5_RS08455	COG0577	efflux transmembrane transporter activity
CMC5_RS08460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS08465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CMC5_RS08465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CMC5_RS08470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CMC5_RS08470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CMC5_RS08475	COG0693	protein deglycase activity
CMC5_RS08475	COG0753	catalase activity
CMC5_RS08525	COG0367	asparagine synthase
CMC5_RS08535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CMC5_RS08555	COG2192	nodulation
CMC5_RS08565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CMC5_RS08605	COG0515	serine threonine protein kinase
CMC5_RS08615	COG2860	membrane
CMC5_RS08620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CMC5_RS08625	COG2011	ABC-type metal ion transport system permease component
CMC5_RS08630	COG1464	Belongs to the NlpA lipoprotein family
CMC5_RS08665	COG0667	Aldo Keto reductase
CMC5_RS08675	COG4552	Acetyltransferase involved in intracellular survival and related
CMC5_RS08680	COG0412	Dienelactone hydrolase
CMC5_RS08715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CMC5_RS08760	COG1830	Aldolase
CMC5_RS08795	COG1335	isochorismatase
CMC5_RS08810	COG4555	ABC transporter
CMC5_RS08825	COG1174	glycine betaine transport
CMC5_RS08885	COG2326	polyphosphate kinase activity
CMC5_RS08895	COG0306	phosphate transporter
CMC5_RS08915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CMC5_RS08930	COG0488	(ABC) transporter
CMC5_RS08940	COG0628	permease
CMC5_RS08945	COG3387	PFAM Glycoside hydrolase 15-related
CMC5_RS08965	COG2111	Na H antiporter
CMC5_RS08965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CMC5_RS08970	COG1006	Multisubunit Na H antiporter MnhC subunit
CMC5_RS08975	COG0651	ATP synthesis coupled electron transport
CMC5_RS08980	COG1863	multisubunit Na H antiporter MnhE subunit
CMC5_RS08985	COG2212	antiporter activity
CMC5_RS09010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CMC5_RS09010	COG5549	protein import
CMC5_RS09075	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS09080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CMC5_RS09090	COG0326	Molecular chaperone. Has ATPase activity
CMC5_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS09125	COG1218	3'(2'),5'-bisphosphate nucleotidase
CMC5_RS09140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CMC5_RS09170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CMC5_RS09175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CMC5_RS09180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CMC5_RS09185	COG0025	NhaP-type Na H and K H
CMC5_RS09195	COG4566	intracellular signal transduction
CMC5_RS09205	COG2205	protein histidine kinase activity
CMC5_RS09205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CMC5_RS09220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CMC5_RS09225	COG0049	tRNA binding
CMC5_RS09230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CMC5_RS09235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CMC5_RS09240	COG0051	transcription antitermination factor activity, RNA binding
CMC5_RS09250	COG0089	rRNA binding
CMC5_RS09255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CMC5_RS09260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CMC5_RS09320	COG1192	Involved in chromosome partitioning
CMC5_RS09345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CMC5_RS09360	COG1201	RNA secondary structure unwinding
CMC5_RS09370	COG0300	oxidoreductase activity
CMC5_RS09405	COG0515	serine threonine protein kinase
CMC5_RS09410	COG0484	heat shock protein binding
CMC5_RS09415	COG0793	Belongs to the peptidase S41A family
CMC5_RS09420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CMC5_RS09480	COG2208	phosphoserine phosphatase activity
CMC5_RS09480	COG2770	Histidine kinase
CMC5_RS09495	COG3206	protein involved in exopolysaccharide biosynthesis
CMC5_RS09495	COG0489	protein tyrosine kinase activity
CMC5_RS09515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CMC5_RS09550	COG0438	transferase activity, transferring glycosyl groups
CMC5_RS09620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CMC5_RS09625	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS09630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CMC5_RS09635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CMC5_RS09640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CMC5_RS09675	COG1940	carbohydrate kinase activity
CMC5_RS09685	COG1181	Belongs to the D-alanine--D-alanine ligase family
CMC5_RS09725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CMC5_RS09735	COG1217	gtp-binding protein TYPA
CMC5_RS09745	COG0693	protein deglycase activity
CMC5_RS09785	COG0142	geranyltranstransferase activity
CMC5_RS09790	COG0142	geranyltranstransferase activity
CMC5_RS09880	COG3852	Histidine kinase
CMC5_RS09905	COG3104	oligopeptide transport
CMC5_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS09935	COG3852	Histidine kinase
CMC5_RS09945	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CMC5_RS10015	COG0515	serine threonine protein kinase
CMC5_RS10015	COG2815	serine threonine protein kinase
CMC5_RS10085	COG2205	protein histidine kinase activity
CMC5_RS10090	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CMC5_RS10130	COG0402	S-adenosylhomocysteine deaminase activity
CMC5_RS10150	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CMC5_RS10190	COG1408	metallophosphoesterase
CMC5_RS10195	COG0515	serine threonine protein kinase
CMC5_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS10325	COG0328	RNA-DNA hybrid ribonuclease activity
CMC5_RS10330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CMC5_RS10335	COG0515	serine threonine protein kinase
CMC5_RS10345	COG0277	FAD linked oxidase domain protein
CMC5_RS10355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CMC5_RS10360	COG0538	isocitrate dehydrogenase activity
CMC5_RS10405	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS10425	COG2204	response regulator
CMC5_RS10450	COG3436	PFAM IS66 Orf2 family protein
CMC5_RS10455	COG4372	Transposase
CMC5_RS10470	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS10475	COG0039	L-malate dehydrogenase activity
CMC5_RS10480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CMC5_RS10485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CMC5_RS10490	COG1301	dicarboxylic acid transport
CMC5_RS10495	COG5002	protein histidine kinase activity
CMC5_RS10495	COG2198	Histidine kinase
CMC5_RS10495	COG0784	Response regulator, receiver
CMC5_RS10580	COG1794	racemase activity, acting on amino acids and derivatives
CMC5_RS10605	COG1215	transferase activity, transferring glycosyl groups
CMC5_RS10700	COG0024	Methionine aminopeptidase
CMC5_RS10705	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CMC5_RS10720	COG0497	DNA recombination
CMC5_RS10740	COG0297	glycogen (starch) synthase activity
CMC5_RS10760	COG2814	Major facilitator Superfamily
CMC5_RS10765	COG0574	Belongs to the PEP-utilizing enzyme family
CMC5_RS10765	COG3848	Pyruvate phosphate dikinase
CMC5_RS10770	COG3848	Pyruvate phosphate dikinase
CMC5_RS10770	COG0574	Belongs to the PEP-utilizing enzyme family
CMC5_RS10775	COG2205	protein histidine kinase activity
CMC5_RS10780	COG2204	response regulator
CMC5_RS10785	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS10790	COG4591	ABC-type transport system involved in lipoprotein release permease component
CMC5_RS10805	COG0617	tRNA 3'-terminal CCA addition
CMC5_RS10825	COG0308	aminopeptidase N
CMC5_RS10840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CMC5_RS10845	COG0402	S-adenosylhomocysteine deaminase activity
CMC5_RS10900	COG0727	PFAM Uncharacterised protein family (UPF0153)
CMC5_RS10910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CMC5_RS10925	COG0215	cysteine-tRNA ligase activity
CMC5_RS10935	COG1024	Enoyl-CoA hydratase
CMC5_RS10945	COG0745	RESPONSE REGULATOR receiver
CMC5_RS10960	COG2205	protein histidine kinase activity
CMC5_RS10970	COG2086	electron transfer activity
CMC5_RS10995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CMC5_RS11005	COG2211	Major facilitator Superfamily
CMC5_RS11040	COG0604	alcohol dehydrogenase
CMC5_RS11040	COG4221	oxidoreductase activity
CMC5_RS11040	COG3321	synthase
CMC5_RS11040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS11050	COG1181	Belongs to the D-alanine--D-alanine ligase family
CMC5_RS11095	COG2815	serine threonine protein kinase
CMC5_RS11095	COG0515	serine threonine protein kinase
CMC5_RS11110	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS11115	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS11120	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS11125	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS11130	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS11135	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS11150	COG0644	oxidoreductase
CMC5_RS11200	COG0583	DNA-binding transcription factor activity
CMC5_RS11240	COG0702	epimerase
CMC5_RS11245	COG5002	protein histidine kinase activity
CMC5_RS11270	COG3693	PFAM glycoside hydrolase, family 10
CMC5_RS11270	COG3507	Belongs to the glycosyl hydrolase 43 family
CMC5_RS11270	COG2382	esterase
CMC5_RS11275	COG1595	DNA-templated transcription, initiation
CMC5_RS11320	COG0488	(ABC) transporter
CMC5_RS11350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CMC5_RS11355	COG1793	dna ligase
CMC5_RS11365	COG0515	serine threonine protein kinase
CMC5_RS11365	COG2815	serine threonine protein kinase
CMC5_RS11370	COG0515	serine threonine protein kinase
CMC5_RS11370	COG2815	serine threonine protein kinase
CMC5_RS11430	COG1301	dicarboxylic acid transport
CMC5_RS11500	COG1064	alcohol dehydrogenase
CMC5_RS11505	COG2207	Transcriptional regulator
CMC5_RS11525	COG2124	cytochrome p450
CMC5_RS11600	COG4264	IucA IucC family
CMC5_RS11695	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS11730	COG2031	fatty acid transporter
CMC5_RS11735	COG4941	Belongs to the sigma-70 factor family
CMC5_RS11745	COG3321	synthase
CMC5_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS11745	COG0604	alcohol dehydrogenase
CMC5_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS11760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CMC5_RS11760	COG2124	cytochrome p450
CMC5_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS11775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CMC5_RS11785	COG2072	flavoprotein involved in K transport
CMC5_RS11935	COG0582	viral genome integration into host DNA
CMC5_RS11950	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CMC5_RS12025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CMC5_RS12045	COG0366	Alpha amylase catalytic
CMC5_RS12050	COG0515	serine threonine protein kinase
CMC5_RS12050	COG2815	serine threonine protein kinase
CMC5_RS12090	COG1442	glycosyl transferase family 8
CMC5_RS12090	COG1216	Glycosyl transferase, family 2
CMC5_RS12100	COG2192	nodulation
CMC5_RS12120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CMC5_RS12120	COG0519	Catalyzes the synthesis of GMP from XMP
CMC5_RS12135	COG3436	PFAM IS66 Orf2 family protein
CMC5_RS12140	COG4372	Transposase
CMC5_RS12185	COG0515	serine threonine protein kinase
CMC5_RS12190	COG1309	transcriptional regulator
CMC5_RS12195	COG1924	4 iron, 4 sulfur cluster binding
CMC5_RS12235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CMC5_RS12270	COG3852	Histidine kinase
CMC5_RS12275	COG1459	type II secretion system
CMC5_RS12320	COG4302	ethanolamine ammonia-lyase activity
CMC5_RS12340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CMC5_RS12355	COG5263	repeat protein
CMC5_RS12355	COG3774	pathogenesis
CMC5_RS12365	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CMC5_RS12375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CMC5_RS12385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CMC5_RS12390	COG4589	Belongs to the CDS family
CMC5_RS12395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CMC5_RS12400	COG3246	L-lysine catabolic process to acetate
CMC5_RS12450	COG0583	DNA-binding transcription factor activity
CMC5_RS12455	COG0515	serine threonine protein kinase
CMC5_RS12490	COG2815	serine threonine protein kinase
CMC5_RS12490	COG0515	serine threonine protein kinase
CMC5_RS12510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CMC5_RS12545	COG2226	methyltransferase
CMC5_RS12580	COG2192	nodulation
CMC5_RS12590	COG0667	Aldo Keto reductase
CMC5_RS12600	COG3179	chitinase
CMC5_RS12605	COG3179	chitinase
CMC5_RS12660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CMC5_RS12685	COG4251	negative regulation of phosphorylation
CMC5_RS12690	COG0784	Response regulator, receiver
CMC5_RS12695	COG2815	serine threonine protein kinase
CMC5_RS12695	COG0515	serine threonine protein kinase
CMC5_RS12710	COG1793	dna ligase
CMC5_RS12720	COG0515	serine threonine protein kinase
CMC5_RS12720	COG2815	serine threonine protein kinase
CMC5_RS12725	COG2204	response regulator
CMC5_RS12730	COG0233	cytoplasmic translational termination
CMC5_RS12735	COG0631	protein serine/threonine phosphatase activity
CMC5_RS12745	COG0626	cystathionine gamma-synthase activity
CMC5_RS12755	COG1404	Belongs to the peptidase S8 family
CMC5_RS12760	COG1404	Belongs to the peptidase S8 family
CMC5_RS12780	COG0123	including yeast histone deacetylase and acetoin utilization protein
CMC5_RS12785	COG0741	lytic transglycosylase activity
CMC5_RS12800	COG3293	Transposase
CMC5_RS12810	COG0515	serine threonine protein kinase
CMC5_RS12855	COG2226	methyltransferase
CMC5_RS12890	COG1305	Transglutaminase-like
CMC5_RS12915	COG0300	oxidoreductase activity
CMC5_RS12930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMC5_RS13000	COG3293	Transposase
CMC5_RS13030	COG2986	histidine ammonia-lyase
CMC5_RS13040	COG0511	ligase activity, forming carbon-carbon bonds
CMC5_RS13045	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CMC5_RS13055	COG0515	serine threonine protein kinase
CMC5_RS13055	COG2815	serine threonine protein kinase
CMC5_RS13065	COG3540	Alkaline phosphatase
CMC5_RS13075	COG1301	dicarboxylic acid transport
CMC5_RS13100	COG1203	CRISPR-associated helicase, Cas3
CMC5_RS13110	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CMC5_RS13150	COG0583	DNA-binding transcription factor activity
CMC5_RS13160	COG0110	maltose O-acetyltransferase activity
CMC5_RS13195	COG1388	LysM domain
CMC5_RS13195	COG3584	3D domain protein
CMC5_RS13225	COG1121	(ABC) transporter
CMC5_RS13255	COG0625	glutathione transferase activity
CMC5_RS13335	COG2814	Major facilitator Superfamily
CMC5_RS13365	COG0346	lactoylglutathione lyase activity
CMC5_RS13385	COG0667	Aldo Keto reductase
CMC5_RS13395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CMC5_RS13405	COG1968	undecaprenyl-diphosphatase activity
CMC5_RS13440	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CMC5_RS13460	COG0625	glutathione transferase activity
CMC5_RS13480	COG2124	cytochrome p450
CMC5_RS13485	COG2124	cytochrome p450
CMC5_RS13490	COG2124	cytochrome p450
CMC5_RS13495	COG2124	cytochrome p450
CMC5_RS13500	COG0477	Major facilitator Superfamily
CMC5_RS13510	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS13520	COG0322	excinuclease ABC activity
CMC5_RS13530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CMC5_RS13535	COG0589	response to stress
CMC5_RS13550	COG3604	Transcriptional regulator
CMC5_RS13555	COG1858	cytochrome C peroxidase
CMC5_RS13575	COG0667	Aldo Keto reductase
CMC5_RS13660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS13665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CMC5_RS13665	COG4651	solute:proton antiporter activity
CMC5_RS13685	COG0617	tRNA 3'-terminal CCA addition
CMC5_RS13695	COG2062	phosphohistidine phosphatase, SixA
CMC5_RS13700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CMC5_RS13720	COG0300	oxidoreductase activity
CMC5_RS13755	COG0829	nickel cation binding
CMC5_RS13765	COG0300	oxidoreductase activity
CMC5_RS13770	COG0831	urea catabolic process
CMC5_RS13770	COG0832	Belongs to the urease beta subunit family
CMC5_RS13775	COG0804	urea catabolic process
CMC5_RS13780	COG0830	nickel cation binding
CMC5_RS13785	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CMC5_RS13820	COG2378	regulation of single-species biofilm formation
CMC5_RS13825	COG2205	protein histidine kinase activity
CMC5_RS13830	COG0784	Response regulator, receiver
CMC5_RS13845	COG1090	epimerase
CMC5_RS13860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CMC5_RS13865	COG1959	2 iron, 2 sulfur cluster binding
CMC5_RS13870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CMC5_RS13870	COG1017	nitric oxide dioxygenase activity
CMC5_RS13875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS13880	COG3220	belongs to the UPF0276 family
CMC5_RS13930	COG3540	Alkaline phosphatase
CMC5_RS13935	COG1131	(ABC) transporter
CMC5_RS13970	COG0798	PFAM Bile acid sodium symporter
CMC5_RS13975	COG0346	lactoylglutathione lyase activity
CMC5_RS14045	COG1733	regulation of RNA biosynthetic process
CMC5_RS14155	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS14165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMC5_RS14170	COG2304	oxidoreductase activity
CMC5_RS14185	COG1921	L-seryl-tRNASec selenium transferase activity
CMC5_RS14235	COG0779	Required for maturation of 30S ribosomal subunits
CMC5_RS14240	COG0195	Participates in both transcription termination and antitermination
CMC5_RS14250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CMC5_RS14260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CMC5_RS14265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CMC5_RS14275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS14285	COG2885	chlorophyll binding
CMC5_RS14310	COG0515	serine threonine protein kinase
CMC5_RS14330	COG2204	response regulator
CMC5_RS14335	COG1131	(ABC) transporter
CMC5_RS14360	COG0588	phosphoglycerate mutase activity
CMC5_RS14365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CMC5_RS14370	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS14380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CMC5_RS14395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CMC5_RS14395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CMC5_RS14400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CMC5_RS14420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CMC5_RS14430	COG0602	queuosine metabolic process
CMC5_RS14530	COG1760	l-serine dehydratase
CMC5_RS14535	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS14560	COG0515	serine threonine protein kinase
CMC5_RS14565	COG2032	superoxide dismutase activity
CMC5_RS14590	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS14655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CMC5_RS14660	COG2815	serine threonine protein kinase
CMC5_RS14660	COG0515	serine threonine protein kinase
CMC5_RS14670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CMC5_RS14680	COG1131	(ABC) transporter
CMC5_RS14760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CMC5_RS14785	COG0604	alcohol dehydrogenase
CMC5_RS14785	COG3321	synthase
CMC5_RS14790	COG3425	synthase
CMC5_RS14795	COG1024	Enoyl-CoA hydratase
CMC5_RS14800	COG1024	Enoyl-CoA hydratase
CMC5_RS14810	COG0300	oxidoreductase activity
CMC5_RS14810	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS14810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS14810	COG3321	synthase
CMC5_RS14810	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS14810	COG3321	synthase
CMC5_RS14810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS14810	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS14810	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS14810	COG0300	oxidoreductase activity
CMC5_RS14825	COG2890	protein-(glutamine-N5) methyltransferase activity
CMC5_RS14830	COG2124	cytochrome p450
CMC5_RS14850	COG3275	phosphorelay sensor kinase activity
CMC5_RS14875	COG2267	carboxylic ester hydrolase activity
CMC5_RS14885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CMC5_RS14895	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS14905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CMC5_RS14980	COG0741	lytic transglycosylase activity
CMC5_RS15040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CMC5_RS15060	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS15070	COG0730	response to heat
CMC5_RS15075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CMC5_RS15080	COG2204	response regulator
CMC5_RS15085	COG0446	pyridine nucleotide-disulphide oxidoreductase
CMC5_RS15090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CMC5_RS15125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CMC5_RS15140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CMC5_RS15145	COG4770	biotin carboxylase activity
CMC5_RS15155	COG0564	pseudouridine synthase activity
CMC5_RS15205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CMC5_RS15220	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS15230	COG2815	serine threonine protein kinase
CMC5_RS15230	COG0515	serine threonine protein kinase
CMC5_RS15240	COG0018	arginyl-trna synthetase
CMC5_RS15250	COG0584	glycerophosphoryl diester phosphodiesterase
CMC5_RS15270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CMC5_RS15275	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CMC5_RS15355	COG1297	OPT oligopeptide transporter protein
CMC5_RS15405	COG0523	cobalamin synthesis protein
CMC5_RS15465	COG0824	Thioesterase
CMC5_RS15475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CMC5_RS15485	COG1304	FMN binding
CMC5_RS15495	COG0745	RESPONSE REGULATOR receiver
CMC5_RS15500	COG3706	GGDEF domain
CMC5_RS15510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CMC5_RS15540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CMC5_RS15550	COG2718	Belongs to the UPF0229 family
CMC5_RS15555	COG2719	SpoVR family
CMC5_RS15565	COG2226	methyltransferase
CMC5_RS15570	COG2208	phosphoserine phosphatase activity
CMC5_RS15595	COG1846	Transcriptional regulator
CMC5_RS15600	COG1024	Enoyl-CoA hydratase
CMC5_RS15605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CMC5_RS15625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CMC5_RS15655	COG0251	oxidation-reduction process
CMC5_RS15685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CMC5_RS15710	COG0515	serine threonine protein kinase
CMC5_RS15710	COG2815	serine threonine protein kinase
CMC5_RS15725	COG0543	2 iron, 2 sulfur cluster binding
CMC5_RS15725	COG0633	Ferredoxin
CMC5_RS15740	COG3047	cAMP biosynthetic process
CMC5_RS15740	COG2885	chlorophyll binding
CMC5_RS15755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CMC5_RS15780	COG3956	TIGRFAM MazG family protein
CMC5_RS15785	COG1024	Enoyl-CoA hydratase
CMC5_RS15790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CMC5_RS15805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS15810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CMC5_RS15815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CMC5_RS15840	COG2815	serine threonine protein kinase
CMC5_RS15840	COG0515	serine threonine protein kinase
CMC5_RS15880	COG0768	penicillin binding
CMC5_RS15885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CMC5_RS15890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CMC5_RS15950	COG0515	serine threonine protein kinase
CMC5_RS15950	COG2815	serine threonine protein kinase
CMC5_RS15970	COG0534	Mate efflux family protein
CMC5_RS16010	COG2373	Large extracellular alpha-helical protein
CMC5_RS16035	COG0714	Associated with various cellular activities
CMC5_RS16045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CMC5_RS16060	COG2204	response regulator
CMC5_RS16075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CMC5_RS16080	COG1045	serine acetyltransferase
CMC5_RS16090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CMC5_RS16110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CMC5_RS16115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CMC5_RS16120	COG1660	Displays ATPase and GTPase activities
CMC5_RS16135	COG0737	Belongs to the 5'-nucleotidase family
CMC5_RS16150	COG1331	Highly conserved protein containing a thioredoxin domain
CMC5_RS16160	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS16170	COG1959	2 iron, 2 sulfur cluster binding
CMC5_RS16180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CMC5_RS16185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CMC5_RS16195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CMC5_RS16205	COG0529	Catalyzes the synthesis of activated sulfate
CMC5_RS16205	COG2046	Belongs to the sulfate adenylyltransferase family
CMC5_RS16225	COG0583	DNA-binding transcription factor activity
CMC5_RS16235	COG0515	serine threonine protein kinase
CMC5_RS16250	COG3104	oligopeptide transport
CMC5_RS16260	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS16280	COG0166	Belongs to the GPI family
CMC5_RS16345	COG1944	ATP diphosphatase activity
CMC5_RS16360	COG1404	Belongs to the peptidase S8 family
CMC5_RS16375	COG1132	(ABC) transporter
CMC5_RS16385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CMC5_RS16385	COG2205	protein histidine kinase activity
CMC5_RS16430	COG0515	serine threonine protein kinase
CMC5_RS16480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CMC5_RS16490	COG1116	anion transmembrane transporter activity
CMC5_RS16495	COG0515	serine threonine protein kinase
CMC5_RS16495	COG2815	serine threonine protein kinase
CMC5_RS16505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CMC5_RS16510	COG1842	Phage shock protein A
CMC5_RS16525	COG2204	response regulator
CMC5_RS16560	COG1733	regulation of RNA biosynthetic process
CMC5_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS16615	COG0629	single-stranded DNA binding
CMC5_RS16640	COG1136	(ABC) transporter
CMC5_RS16640	COG0577	efflux transmembrane transporter activity
CMC5_RS16645	COG0577	efflux transmembrane transporter activity
CMC5_RS16645	COG1136	(ABC) transporter
CMC5_RS16650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS16655	COG3361	conserved protein (COG2071)
CMC5_RS16675	COG0583	DNA-binding transcription factor activity
CMC5_RS16695	COG0789	Transcriptional regulator
CMC5_RS16740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CMC5_RS16745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CMC5_RS16765	COG1022	Amp-dependent synthetase and ligase
CMC5_RS16770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CMC5_RS16780	COG2104	thiamine diphosphate biosynthetic process
CMC5_RS16785	COG2264	protein methyltransferase activity
CMC5_RS16795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CMC5_RS16810	COG0667	Aldo Keto reductase
CMC5_RS16845	COG0791	NLP P60 protein
CMC5_RS16855	COG1234	tRNA 3'-trailer cleavage
CMC5_RS16865	COG0352	thiamine-phosphate diphosphorylase activity
CMC5_RS16880	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CMC5_RS16890	COG0470	DNA polymerase III
CMC5_RS16910	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CMC5_RS16935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CMC5_RS16940	COG2124	cytochrome p450
CMC5_RS16955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CMC5_RS16960	COG3852	Histidine kinase
CMC5_RS16980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CMC5_RS16990	COG1183	phosphatidylcholine synthase activity
CMC5_RS17010	COG0179	Fumarylacetoacetate (FAA) hydrolase
CMC5_RS17035	COG2602	Beta-lactamase
CMC5_RS17040	COG0583	DNA-binding transcription factor activity
CMC5_RS17105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CMC5_RS17115	COG1335	isochorismatase
CMC5_RS17125	COG4149	molybdate abc transporter
CMC5_RS17130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CMC5_RS17175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CMC5_RS17180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CMC5_RS17195	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS17200	COG1376	ErfK ybiS ycfS ynhG family protein
CMC5_RS17205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS17215	COG0446	pyridine nucleotide-disulphide oxidoreductase
CMC5_RS17215	COG1902	pentaerythritol trinitrate reductase activity
CMC5_RS17220	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS17225	COG1024	Enoyl-CoA hydratase
CMC5_RS17235	COG0251	oxidation-reduction process
CMC5_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS17260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CMC5_RS17335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CMC5_RS17340	COG0509	glycine decarboxylation via glycine cleavage system
CMC5_RS17345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CMC5_RS17375	COG4968	Prepilin-type N-terminal cleavage methylation domain
CMC5_RS17385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CMC5_RS17390	COG2030	dehydratase
CMC5_RS17410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CMC5_RS17435	COG0312	modulator of DNA gyrase
CMC5_RS17445	COG1691	(AIR) carboxylase
CMC5_RS17450	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CMC5_RS17455	COG3118	belongs to the thioredoxin family
CMC5_RS17460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CMC5_RS17465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CMC5_RS17470	COG0601	transmembrane transport
CMC5_RS17475	COG0631	protein serine/threonine phosphatase activity
CMC5_RS17505	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CMC5_RS17530	COG0745	RESPONSE REGULATOR receiver
CMC5_RS17560	COG4771	TonB-dependent receptor
CMC5_RS17570	COG3720	iron ion transport
CMC5_RS17575	COG4558	Periplasmic binding protein
CMC5_RS17580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CMC5_RS17585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CMC5_RS17595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CMC5_RS17605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CMC5_RS17680	COG0612	Peptidase, M16
CMC5_RS17685	COG0612	Peptidase, M16
CMC5_RS17720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CMC5_RS17755	COG1505	serine-type exopeptidase activity
CMC5_RS17775	COG0640	Transcriptional regulator
CMC5_RS17780	COG3265	gluconokinase activity
CMC5_RS17795	COG0667	Aldo Keto reductase
CMC5_RS17800	COG0183	Belongs to the thiolase family
CMC5_RS17815	COG0778	Nitroreductase
CMC5_RS17820	COG0583	DNA-binding transcription factor activity
CMC5_RS17830	COG2124	cytochrome p450
CMC5_RS17835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CMC5_RS17875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CMC5_RS17890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CMC5_RS17910	COG2815	serine threonine protein kinase
CMC5_RS17910	COG0515	serine threonine protein kinase
CMC5_RS17920	COG1309	transcriptional regulator
CMC5_RS17925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CMC5_RS17975	COG0657	acetylesterase activity
CMC5_RS17995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CMC5_RS18150	COG1335	isochorismatase
CMC5_RS18170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CMC5_RS18175	COG1295	ribonuclease BN
CMC5_RS18180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CMC5_RS18270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CMC5_RS18275	COG0459	protein refolding
CMC5_RS18280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS18295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CMC5_RS18325	COG3852	Histidine kinase
CMC5_RS18330	COG2204	response regulator
CMC5_RS18375	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS18390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMC5_RS18430	COG3179	chitinase
CMC5_RS18475	COG1201	RNA secondary structure unwinding
CMC5_RS18560	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS18570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CMC5_RS18575	COG5002	protein histidine kinase activity
CMC5_RS18600	COG2814	Major facilitator Superfamily
CMC5_RS18620	COG4191	Histidine kinase
CMC5_RS18625	COG0708	Exodeoxyribonuclease III
CMC5_RS18635	COG0124	histidyl-tRNA synthetase
CMC5_RS18640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CMC5_RS18645	COG0515	serine threonine protein kinase
CMC5_RS18645	COG2815	serine threonine protein kinase
CMC5_RS18650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CMC5_RS18655	COG1185	polyribonucleotide nucleotidyltransferase activity
CMC5_RS18720	COG4191	Histidine kinase
CMC5_RS18730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CMC5_RS18740	COG2226	methyltransferase
CMC5_RS18775	COG0659	secondary active sulfate transmembrane transporter activity
CMC5_RS18780	COG2205	protein histidine kinase activity
CMC5_RS18785	COG2204	response regulator
CMC5_RS18795	COG1307	EDD domain protein, DegV family
CMC5_RS18800	COG2354	Protein conserved in bacteria
CMC5_RS18810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CMC5_RS18830	COG0745	RESPONSE REGULATOR receiver
CMC5_RS18840	COG0811	peptide transport
CMC5_RS18895	COG2202	Pas domain
CMC5_RS18895	COG2205	protein histidine kinase activity
CMC5_RS18900	COG2201	protein-glutamate methylesterase activity
CMC5_RS18910	COG0840	transmembrane signaling receptor activity
CMC5_RS18950	COG0430	RNA-3'-phosphate cyclase activity
CMC5_RS19000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CMC5_RS19005	COG0505	Belongs to the CarA family
CMC5_RS19020	COG0303	'Molybdopterin
CMC5_RS19025	COG0521	Mo-molybdopterin cofactor biosynthetic process
CMC5_RS19035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CMC5_RS19045	COG0724	RNA recognition motif
CMC5_RS19050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CMC5_RS19060	COG1792	Involved in formation and maintenance of cell shape
CMC5_RS19075	COG0772	Belongs to the SEDS family
CMC5_RS19080	COG1100	Small GTP-binding protein
CMC5_RS19115	COG0443	Heat shock 70 kDa protein
CMC5_RS19175	COG1131	(ABC) transporter
CMC5_RS19190	COG0745	RESPONSE REGULATOR receiver
CMC5_RS19195	COG5002	protein histidine kinase activity
CMC5_RS19255	COG0741	lytic transglycosylase activity
CMC5_RS19275	COG1166	arginine decarboxylase activity
CMC5_RS19285	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CMC5_RS19305	COG2204	response regulator
CMC5_RS19315	COG4191	Histidine kinase
CMC5_RS19320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CMC5_RS19325	COG0604	alcohol dehydrogenase
CMC5_RS19355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CMC5_RS19375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CMC5_RS19405	COG0439	Biotin carboxylase
CMC5_RS19435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CMC5_RS19455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CMC5_RS19460	COG0494	nUDIX hydrolase
CMC5_RS19480	COG0187	DNA topoisomerase II activity
CMC5_RS19485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CMC5_RS19490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CMC5_RS19510	COG0358	DNA primase activity
CMC5_RS19515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CMC5_RS19520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CMC5_RS19525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CMC5_RS19535	COG0714	Associated with various cellular activities
CMC5_RS19545	COG0228	four-way junction DNA binding
CMC5_RS19550	COG1837	Belongs to the UPF0109 family
CMC5_RS19555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CMC5_RS19560	COG0336	Belongs to the RNA methyltransferase TrmD family
CMC5_RS19565	COG4752	Belongs to the RNA methyltransferase TrmD family
CMC5_RS19570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CMC5_RS19590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CMC5_RS19605	COG4974	Belongs to the 'phage' integrase family
CMC5_RS19635	COG1131	(ABC) transporter
CMC5_RS19640	COG2223	nitrite transmembrane transporter activity
CMC5_RS19650	COG2373	Large extracellular alpha-helical protein
CMC5_RS19655	COG4953	penicillin-binding protein 1C
CMC5_RS19685	COG0167	dihydroorotate dehydrogenase activity
CMC5_RS19695	COG0010	Belongs to the arginase family
CMC5_RS19705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CMC5_RS19705	COG0321	lipoyl(octanoyl) transferase activity
CMC5_RS19715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CMC5_RS19725	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS19740	COG2967	ApaG domain
CMC5_RS19750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CMC5_RS19760	COG0058	SHG alpha-glucan phosphorylase activity
CMC5_RS19770	COG0489	protein tyrosine kinase activity
CMC5_RS19785	COG0631	protein serine/threonine phosphatase activity
CMC5_RS19825	COG0517	IMP dehydrogenase activity
CMC5_RS19840	COG2815	serine threonine protein kinase
CMC5_RS19840	COG0515	serine threonine protein kinase
CMC5_RS19850	COG0631	protein serine/threonine phosphatase activity
CMC5_RS19855	COG0515	serine threonine protein kinase
CMC5_RS19870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CMC5_RS19875	COG2815	serine threonine protein kinase
CMC5_RS19875	COG0515	serine threonine protein kinase
CMC5_RS19915	COG0713	ATP synthesis coupled electron transport
CMC5_RS19930	COG1007	ATP synthesis coupled electron transport
CMC5_RS20005	COG1132	(ABC) transporter
CMC5_RS20010	COG1543	Belongs to the glycosyl hydrolase 57 family
CMC5_RS20065	COG0142	geranyltranstransferase activity
CMC5_RS20090	COG1100	Small GTP-binding protein
CMC5_RS20115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CMC5_RS20120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CMC5_RS20145	COG0714	Associated with various cellular activities
CMC5_RS20155	COG1187	pseudouridine synthase activity
CMC5_RS20175	COG0481	GTPase activity
CMC5_RS20180	COG0612	Peptidase, M16
CMC5_RS20205	COG0367	asparagine synthase
CMC5_RS20210	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS20220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CMC5_RS20225	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CMC5_RS20230	COG0540	Belongs to the ATCase OTCase family
CMC5_RS20250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CMC5_RS20260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CMC5_RS20265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CMC5_RS20270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CMC5_RS20275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CMC5_RS20275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CMC5_RS20295	COG1278	Cold shock
CMC5_RS20300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS20305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CMC5_RS20320	COG0508	dehydrogenase complex catalyzes the overall conversion of
CMC5_RS20325	COG0022	dehydrogenase e1 component
CMC5_RS20325	COG0508	dehydrogenase complex catalyzes the overall conversion of
CMC5_RS20330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CMC5_RS20340	COG0515	serine threonine protein kinase
CMC5_RS20350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CMC5_RS20355	COG2205	protein histidine kinase activity
CMC5_RS20355	COG2198	Histidine kinase
CMC5_RS20355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CMC5_RS20355	COG0784	Response regulator, receiver
CMC5_RS20360	COG0784	Response regulator, receiver
CMC5_RS20360	COG5002	protein histidine kinase activity
CMC5_RS20360	COG2198	Histidine kinase
CMC5_RS20385	COG2204	response regulator
CMC5_RS20460	COG2723	6-phospho-beta-galactosidase activity
CMC5_RS20465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CMC5_RS20475	COG0756	dUTP diphosphatase activity
CMC5_RS20480	COG0750	zinc metalloprotease
CMC5_RS20505	COG0300	oxidoreductase activity
CMC5_RS20530	COG0432	Pfam Uncharacterised protein family UPF0047
CMC5_RS20540	COG3220	belongs to the UPF0276 family
CMC5_RS20590	COG2124	cytochrome p450
CMC5_RS20625	COG3034	peptidoglycan biosynthetic process
CMC5_RS20655	COG0601	transmembrane transport
CMC5_RS20660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CMC5_RS20665	COG0444	Belongs to the ABC transporter superfamily
CMC5_RS20670	COG4608	Belongs to the ABC transporter superfamily
CMC5_RS20680	COG0271	Belongs to the BolA IbaG family
CMC5_RS20690	COG0517	IMP dehydrogenase activity
CMC5_RS20690	COG0516	GMP reductase activity
CMC5_RS20705	COG2197	response regulator
CMC5_RS20725	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS20730	COG0572	uridine kinase
CMC5_RS20740	COG0346	lactoylglutathione lyase activity
CMC5_RS20890	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CMC5_RS20930	COG0811	peptide transport
CMC5_RS20960	COG0604	alcohol dehydrogenase
CMC5_RS20960	COG3321	synthase
CMC5_RS20960	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS20965	COG1505	serine-type exopeptidase activity
CMC5_RS20975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CMC5_RS20990	COG0012	GTP binding
CMC5_RS21000	COG2261	transglycosylase associated protein
CMC5_RS21020	COG0515	serine threonine protein kinase
CMC5_RS21045	COG0024	Methionine aminopeptidase
CMC5_RS21050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CMC5_RS21075	COG0456	acetyltransferase
CMC5_RS21100	COG0702	epimerase
CMC5_RS21130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CMC5_RS21210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CMC5_RS21215	COG0137	argininosuccinate synthase activity
CMC5_RS21220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CMC5_RS21225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CMC5_RS21230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CMC5_RS21235	COG0165	Argininosuccinate lyase
CMC5_RS21245	COG4991	sh3 domain protein
CMC5_RS21270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CMC5_RS21285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CMC5_RS21290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CMC5_RS21310	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CMC5_RS21315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CMC5_RS21330	COG0811	peptide transport
CMC5_RS21365	COG1078	dGTPase activity
CMC5_RS21375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CMC5_RS21390	COG3844	kynureninase activity
CMC5_RS21405	COG0667	Aldo Keto reductase
CMC5_RS21420	COG4221	oxidoreductase activity
CMC5_RS21455	COG0142	geranyltranstransferase activity
CMC5_RS21460	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CMC5_RS21465	COG2226	methyltransferase
CMC5_RS21475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CMC5_RS21480	COG1575	Belongs to the MenA family. Type 1 subfamily
CMC5_RS21485	COG4948	Mandelate Racemase Muconate Lactonizing
CMC5_RS21550	COG1446	asparaginase
CMC5_RS21555	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS21570	COG1297	OPT oligopeptide transporter protein
CMC5_RS21585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CMC5_RS21590	COG1127	ABC transporter
CMC5_RS21595	COG3008	intermembrane lipid transfer
CMC5_RS21595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CMC5_RS21610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS21625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CMC5_RS21630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CMC5_RS21640	COG0363	glucosamine-6-phosphate deaminase activity
CMC5_RS21675	COG0837	glucose binding
CMC5_RS21700	COG2267	carboxylic ester hydrolase activity
CMC5_RS21730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS21730	COG0515	serine threonine protein kinase
CMC5_RS21765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CMC5_RS21780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CMC5_RS21795	COG0437	4 iron, 4 sulfur cluster binding
CMC5_RS21825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CMC5_RS21835	COG0515	serine threonine protein kinase
CMC5_RS21905	COG5002	protein histidine kinase activity
CMC5_RS21910	COG0745	RESPONSE REGULATOR receiver
CMC5_RS21915	COG0724	RNA recognition motif
CMC5_RS21935	COG0352	thiamine-phosphate diphosphorylase activity
CMC5_RS21940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CMC5_RS21950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CMC5_RS21955	COG4804	nuclease activity
CMC5_RS21960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CMC5_RS22005	COG0577	efflux transmembrane transporter activity
CMC5_RS22005	COG1136	(ABC) transporter
CMC5_RS22025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CMC5_RS22025	COG0515	serine threonine protein kinase
CMC5_RS22040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CMC5_RS22050	COG0515	serine threonine protein kinase
CMC5_RS22055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CMC5_RS22065	COG2815	serine threonine protein kinase
CMC5_RS22065	COG0515	serine threonine protein kinase
CMC5_RS22075	COG1595	DNA-templated transcription, initiation
CMC5_RS22085	COG2119	membrane
CMC5_RS22090	COG0281	malic enzyme
CMC5_RS22090	COG0280	phosphate acetyltransferase
CMC5_RS22100	COG2226	methyltransferase
CMC5_RS22135	COG2814	Major facilitator Superfamily
CMC5_RS22145	COG2197	response regulator
CMC5_RS22150	COG2197	response regulator
CMC5_RS22170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CMC5_RS22215	COG0631	protein serine/threonine phosphatase activity
CMC5_RS22230	COG1127	ABC transporter
CMC5_RS22285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CMC5_RS22290	COG0799	negative regulation of ribosome biogenesis
CMC5_RS22295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CMC5_RS22395	COG0515	serine threonine protein kinase
CMC5_RS22395	COG2815	serine threonine protein kinase
CMC5_RS22465	COG3386	PFAM SMP-30 Gluconolaconase
CMC5_RS22495	COG0052	Belongs to the universal ribosomal protein uS2 family
CMC5_RS22535	COG0513	Belongs to the DEAD box helicase family
CMC5_RS22545	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS22550	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS22555	COG2172	sigma factor antagonist activity
CMC5_RS22615	COG2204	response regulator
CMC5_RS22630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CMC5_RS22635	COG3119	arylsulfatase activity
CMC5_RS22685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CMC5_RS22695	COG1181	Belongs to the D-alanine--D-alanine ligase family
CMC5_RS22710	COG2815	serine threonine protein kinase
CMC5_RS22710	COG0515	serine threonine protein kinase
CMC5_RS22730	COG1846	Transcriptional regulator
CMC5_RS22830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CMC5_RS22835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CMC5_RS22840	COG1127	ABC transporter
CMC5_RS22850	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CMC5_RS22860	COG0284	orotidine-5'-phosphate decarboxylase activity
CMC5_RS22865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CMC5_RS22870	COG1104	cysteine desulfurase activity
CMC5_RS22875	COG2205	protein histidine kinase activity
CMC5_RS22880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CMC5_RS22885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CMC5_RS22895	COG3359	exonuclease
CMC5_RS22900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CMC5_RS22905	COG1619	proteins homologs of microcin C7 resistance protein MccF
CMC5_RS22940	COG2096	Adenosyltransferase
CMC5_RS22950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CMC5_RS23045	COG0583	DNA-binding transcription factor activity
CMC5_RS23050	COG1070	Carbohydrate kinase
CMC5_RS23055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CMC5_RS23120	COG3795	YCII-related domain
CMC5_RS23140	COG0784	Response regulator, receiver
CMC5_RS23140	COG2205	protein histidine kinase activity
CMC5_RS23140	COG5002	protein histidine kinase activity
CMC5_RS23150	COG0515	serine threonine protein kinase
CMC5_RS23175	COG0789	Transcriptional regulator
CMC5_RS23205	COG2508	Transcriptional regulator
CMC5_RS23245	COG2508	Transcriptional regulator
CMC5_RS23250	COG2072	flavoprotein involved in K transport
CMC5_RS23265	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS23275	COG1858	cytochrome C peroxidase
CMC5_RS23295	COG1595	DNA-templated transcription, initiation
CMC5_RS23330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CMC5_RS23375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CMC5_RS23410	COG3848	Pyruvate phosphate dikinase
CMC5_RS23410	COG0574	Belongs to the PEP-utilizing enzyme family
CMC5_RS23435	COG3321	synthase
CMC5_RS23435	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS23435	COG0604	alcohol dehydrogenase
CMC5_RS23690	COG1098	S1 RNA binding domain
CMC5_RS23720	COG2204	response regulator
CMC5_RS23735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CMC5_RS23745	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS23770	COG0564	pseudouridine synthase activity
CMC5_RS23785	COG1192	Involved in chromosome partitioning
CMC5_RS23790	COG0138	bifunctional purine biosynthesis protein purh
CMC5_RS23795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CMC5_RS23805	COG0740	serine-type endopeptidase activity
CMC5_RS23810	COG0544	peptidyl-prolyl cis-trans isomerase activity
CMC5_RS23830	COG1475	DNA binding
CMC5_RS23845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CMC5_RS23860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CMC5_RS23885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CMC5_RS23890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CMC5_RS23915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CMC5_RS23985	COG1183	phosphatidylcholine synthase activity
CMC5_RS23990	COG3903	Transcriptional regulator
CMC5_RS23990	COG2319	Wd-40 repeat
CMC5_RS24000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CMC5_RS24020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CMC5_RS24035	COG0745	RESPONSE REGULATOR receiver
CMC5_RS24040	COG0515	serine threonine protein kinase
CMC5_RS24055	COG0864	Transcriptional regulator
CMC5_RS24060	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS24075	COG3209	COG3209 Rhs family protein
CMC5_RS24135	COG3209	COG3209 Rhs family protein
CMC5_RS24160	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CMC5_RS24205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CMC5_RS24210	COG0366	Alpha amylase catalytic
CMC5_RS24215	COG2814	Major facilitator Superfamily
CMC5_RS24225	COG0018	arginyl-trna synthetase
CMC5_RS24235	COG0237	dephospho-CoA kinase activity
CMC5_RS24240	COG0494	nUDIX hydrolase
CMC5_RS24245	COG5002	protein histidine kinase activity
CMC5_RS24245	COG5001	Diguanylate cyclase
CMC5_RS24260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CMC5_RS24265	COG2819	hydrolase of the alpha beta superfamily
CMC5_RS24300	COG2998	abc-type tungstate transport system, permease component
CMC5_RS24350	COG1846	Transcriptional regulator
CMC5_RS24375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CMC5_RS24440	COG0583	DNA-binding transcription factor activity
CMC5_RS24455	COG1064	alcohol dehydrogenase
CMC5_RS24460	COG0662	Cupin 2, conserved barrel domain protein
CMC5_RS24460	COG2207	Transcriptional regulator
CMC5_RS24465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CMC5_RS24485	COG2201	protein-glutamate methylesterase activity
CMC5_RS24495	COG3268	Saccharopine dehydrogenase
CMC5_RS24515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CMC5_RS24525	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS24560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CMC5_RS24570	COG0542	response to heat
CMC5_RS24585	COG2885	chlorophyll binding
CMC5_RS24605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS24625	COG1561	YicC-like family, N-terminal region
CMC5_RS24630	COG0194	GDP metabolic process
CMC5_RS24635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CMC5_RS24650	COG0515	serine threonine protein kinase
CMC5_RS24660	COG0442	prolyl-tRNA aminoacylation
CMC5_RS24670	COG2204	response regulator
CMC5_RS24675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CMC5_RS24715	COG0728	peptidoglycan biosynthetic process
CMC5_RS24735	COG0084	hydrolase, TatD family'
CMC5_RS24750	COG2815	serine threonine protein kinase
CMC5_RS24750	COG0515	serine threonine protein kinase
CMC5_RS24780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CMC5_RS24795	COG0745	RESPONSE REGULATOR receiver
CMC5_RS24800	COG0860	N-Acetylmuramoyl-L-alanine amidase
CMC5_RS24830	COG0631	protein serine/threonine phosphatase activity
CMC5_RS24850	COG0564	pseudouridine synthase activity
CMC5_RS24860	COG0585	pseudouridine synthase activity
CMC5_RS24865	COG0811	peptide transport
CMC5_RS24895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CMC5_RS24900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CMC5_RS24905	COG3501	Rhs element vgr protein
CMC5_RS24945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CMC5_RS24990	COG0515	serine threonine protein kinase
CMC5_RS24990	COG2815	serine threonine protein kinase
CMC5_RS25030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CMC5_RS25035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CMC5_RS25040	COG0805	protein transport
CMC5_RS25050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CMC5_RS25055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CMC5_RS25070	COG1111	helicase
CMC5_RS25070	COG1205	dead DEAH box helicase
CMC5_RS25115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CMC5_RS25120	COG0515	serine threonine protein kinase
CMC5_RS25120	COG2815	serine threonine protein kinase
CMC5_RS25130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CMC5_RS25135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CMC5_RS25140	COG1534	Rna-binding protein
CMC5_RS25145	COG0543	2 iron, 2 sulfur cluster binding
CMC5_RS25145	COG0493	'glutamate synthase
CMC5_RS25155	COG0439	Biotin carboxylase
CMC5_RS25160	COG0511	ligase activity, forming carbon-carbon bonds
CMC5_RS25170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CMC5_RS25225	COG0006	proline dipeptidase activity
CMC5_RS25265	COG2261	transglycosylase associated protein
CMC5_RS25295	COG0655	NAD(P)H dehydrogenase (quinone) activity
CMC5_RS25300	COG1454	alcohol dehydrogenase
CMC5_RS25305	COG0824	Thioesterase
CMC5_RS25370	COG1032	radical SAM domain protein
CMC5_RS25375	COG0535	radical SAM domain protein
CMC5_RS25475	COG0135	phosphoribosylanthranilate isomerase activity
CMC5_RS25480	COG1022	Amp-dependent synthetase and ligase
CMC5_RS25480	COG3320	Male sterility
CMC5_RS25505	COG0583	DNA-binding transcription factor activity
CMC5_RS25520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CMC5_RS25525	COG2022	thiamine diphosphate biosynthetic process
CMC5_RS25545	COG0668	transmembrane transport
CMC5_RS25550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CMC5_RS25610	COG0204	Acyl-transferase
CMC5_RS25620	COG2815	serine threonine protein kinase
CMC5_RS25620	COG0515	serine threonine protein kinase
CMC5_RS25655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CMC5_RS25660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CMC5_RS25680	COG4968	Prepilin-type N-terminal cleavage methylation domain
CMC5_RS25685	COG4969	Belongs to the N-Me-Phe pilin family
CMC5_RS25710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CMC5_RS25715	COG0154	amidase activity
CMC5_RS25740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CMC5_RS25760	COG0512	Glutamine amidotransferase of anthranilate synthase
CMC5_RS25765	COG2183	response to ionizing radiation
CMC5_RS25775	COG1228	amidohydrolase
CMC5_RS25800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CMC5_RS25840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CMC5_RS25845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CMC5_RS25865	COG3604	Transcriptional regulator
CMC5_RS25880	COG0693	protein deglycase activity
CMC5_RS25895	COG0583	DNA-binding transcription factor activity
CMC5_RS25900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS25905	COG0667	Aldo Keto reductase
CMC5_RS25935	COG1518	maintenance of DNA repeat elements
CMC5_RS25935	COG1468	defense response to virus
CMC5_RS25955	COG1203	CRISPR-associated helicase, Cas3
CMC5_RS25990	COG0515	serine threonine protein kinase
CMC5_RS25995	COG0515	serine threonine protein kinase
CMC5_RS26035	COG1764	response to oxidative stress
CMC5_RS26055	COG1858	cytochrome C peroxidase
CMC5_RS26090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CMC5_RS26155	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS26160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS26180	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CMC5_RS26185	COG3647	Membrane
CMC5_RS26190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CMC5_RS26195	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS26200	COG2124	cytochrome p450
CMC5_RS26215	COG0604	alcohol dehydrogenase
CMC5_RS26215	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS26215	COG3321	synthase
CMC5_RS26240	COG1250	3-hydroxyacyl-CoA dehydrogenase
CMC5_RS26250	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS26275	COG0183	Belongs to the thiolase family
CMC5_RS26285	COG0583	DNA-binding transcription factor activity
CMC5_RS26290	COG2207	Transcriptional regulator
CMC5_RS26295	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS26365	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS26375	COG1250	3-hydroxyacyl-CoA dehydrogenase
CMC5_RS26400	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS26405	COG1703	isobutyryl-CoA mutase activity
CMC5_RS26420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CMC5_RS26420	COG1703	isobutyryl-CoA mutase activity
CMC5_RS26420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CMC5_RS26430	COG0517	IMP dehydrogenase activity
CMC5_RS26450	COG0071	Belongs to the small heat shock protein (HSP20) family
CMC5_RS26455	COG3959	Transketolase, thiamine diphosphate binding domain
CMC5_RS26490	COG0436	Aminotransferase
CMC5_RS26505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS26520	COG2124	cytochrome p450
CMC5_RS26560	COG0454	-acetyltransferase
CMC5_RS26560	COG0456	acetyltransferase
CMC5_RS26580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CMC5_RS26595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CMC5_RS26625	COG0604	alcohol dehydrogenase
CMC5_RS26625	COG3321	synthase
CMC5_RS26725	COG3501	Rhs element vgr protein
CMC5_RS26825	COG2234	aminopeptidase activity
CMC5_RS26840	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS26850	COG1595	DNA-templated transcription, initiation
CMC5_RS26955	COG0604	alcohol dehydrogenase
CMC5_RS26955	COG3321	synthase
CMC5_RS26965	COG3321	synthase
CMC5_RS26965	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS26965	COG0604	alcohol dehydrogenase
CMC5_RS26970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS26970	COG2226	methyltransferase
CMC5_RS26970	COG3433	isochorismatase activity
CMC5_RS26975	COG3321	synthase
CMC5_RS26975	COG0604	alcohol dehydrogenase
CMC5_RS26975	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS26990	COG0604	alcohol dehydrogenase
CMC5_RS26990	COG3321	synthase
CMC5_RS27000	COG2124	cytochrome p450
CMC5_RS27005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS27005	COG3321	synthase
CMC5_RS27130	COG2304	oxidoreductase activity
CMC5_RS27260	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS27280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CMC5_RS27285	COG3275	phosphorelay sensor kinase activity
CMC5_RS27350	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS27370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CMC5_RS27370	COG2755	lipolytic protein G-D-S-L family
CMC5_RS27375	COG0477	Major facilitator Superfamily
CMC5_RS27385	COG1401	restriction endodeoxyribonuclease activity
CMC5_RS27400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS27400	COG3321	synthase
CMC5_RS27420	COG1643	Atp-dependent helicase
CMC5_RS27430	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS27495	COG1199	ATP-dependent helicase activity
CMC5_RS27515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CMC5_RS27520	COG0612	Peptidase, M16
CMC5_RS27525	COG1196	nuclear chromosome segregation
CMC5_RS27555	COG4221	oxidoreductase activity
CMC5_RS27565	COG0640	Transcriptional regulator
CMC5_RS27580	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS27580	COG3347	Dehydrogenase
CMC5_RS27590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CMC5_RS27600	COG0515	serine threonine protein kinase
CMC5_RS27615	COG0515	serine threonine protein kinase
CMC5_RS27645	COG0534	Mate efflux family protein
CMC5_RS27660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CMC5_RS27660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CMC5_RS27685	COG2205	protein histidine kinase activity
CMC5_RS27695	COG2171	N-acyltransferase activity
CMC5_RS27705	COG0105	UTP biosynthetic process
CMC5_RS27715	COG5002	protein histidine kinase activity
CMC5_RS27720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CMC5_RS27725	COG0704	Plays a role in the regulation of phosphate uptake
CMC5_RS27730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CMC5_RS27735	COG0573	inorganic phosphate transmembrane transporter activity
CMC5_RS27775	COG1335	isochorismatase
CMC5_RS27780	COG4221	oxidoreductase activity
CMC5_RS27785	COG2207	Transcriptional regulator
CMC5_RS27815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CMC5_RS27830	COG0640	Transcriptional regulator
CMC5_RS27840	COG2207	Transcriptional regulator
CMC5_RS27860	COG0583	DNA-binding transcription factor activity
CMC5_RS27865	COG0667	Aldo Keto reductase
CMC5_RS27890	COG1064	alcohol dehydrogenase
CMC5_RS27930	COG0315	cyclic pyranopterin monophosphate synthase activity
CMC5_RS27935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CMC5_RS27950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CMC5_RS27960	COG2815	serine threonine protein kinase
CMC5_RS27960	COG0515	serine threonine protein kinase
CMC5_RS27965	COG0534	Mate efflux family protein
CMC5_RS28010	COG0412	Dienelactone hydrolase
CMC5_RS28020	COG0515	serine threonine protein kinase
CMC5_RS28020	COG2815	serine threonine protein kinase
CMC5_RS28030	COG1704	LemA family
CMC5_RS28040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CMC5_RS28050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS28055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS28065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CMC5_RS28070	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CMC5_RS28075	COG3848	Pyruvate phosphate dikinase
CMC5_RS28075	COG0574	Belongs to the PEP-utilizing enzyme family
CMC5_RS28090	COG1335	isochorismatase
CMC5_RS28195	COG1741	Belongs to the pirin family
CMC5_RS28225	COG0519	Catalyzes the synthesis of GMP from XMP
CMC5_RS28230	COG0667	Aldo Keto reductase
CMC5_RS28235	COG0596	Alpha beta hydrolase
CMC5_RS28265	COG0154	amidase activity
CMC5_RS28280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CMC5_RS28295	COG0515	serine threonine protein kinase
CMC5_RS28315	COG1215	transferase activity, transferring glycosyl groups
CMC5_RS28350	COG0745	RESPONSE REGULATOR receiver
CMC5_RS28355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CMC5_RS28360	COG2321	neutral zinc metallopeptidase
CMC5_RS28370	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS28385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CMC5_RS28405	COG3850	Histidine kinase
CMC5_RS28405	COG0642	Histidine kinase
CMC5_RS28455	COG3284	Transcriptional regulator
CMC5_RS28460	COG2815	serine threonine protein kinase
CMC5_RS28460	COG0515	serine threonine protein kinase
CMC5_RS28470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CMC5_RS28475	COG0515	serine threonine protein kinase
CMC5_RS28475	COG2815	serine threonine protein kinase
CMC5_RS28490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CMC5_RS28585	COG1231	oxidoreductase activity
CMC5_RS28610	COG0702	epimerase
CMC5_RS28630	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CMC5_RS28635	COG1501	Belongs to the glycosyl hydrolase 31 family
CMC5_RS28640	COG0442	prolyl-tRNA aminoacylation
CMC5_RS28665	COG0515	serine threonine protein kinase
CMC5_RS28740	COG0552	protein localization to endoplasmic reticulum
CMC5_RS28790	COG2204	response regulator
CMC5_RS28795	COG1999	signal sequence binding
CMC5_RS28800	COG0109	protoheme IX farnesyltransferase activity
CMC5_RS28815	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS28820	COG0484	heat shock protein binding
CMC5_RS28830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CMC5_RS28835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CMC5_RS28885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CMC5_RS28905	COG0583	DNA-binding transcription factor activity
CMC5_RS28910	COG1360	Flagellar Motor Protein
CMC5_RS28925	COG0438	transferase activity, transferring glycosyl groups
CMC5_RS28925	COG1216	Glycosyl transferase, family 2
CMC5_RS28930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CMC5_RS28940	COG0297	glycogen (starch) synthase activity
CMC5_RS28955	COG1228	amidohydrolase
CMC5_RS28965	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS28975	COG0339	signal peptide processing
CMC5_RS29000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CMC5_RS29010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CMC5_RS29050	COG0436	Aminotransferase
CMC5_RS29060	COG1127	ABC transporter
CMC5_RS29065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CMC5_RS29065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CMC5_RS29070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CMC5_RS29075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CMC5_RS29090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CMC5_RS29095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CMC5_RS29105	COG0515	serine threonine protein kinase
CMC5_RS29120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CMC5_RS29135	COG0515	serine threonine protein kinase
CMC5_RS29135	COG2815	serine threonine protein kinase
CMC5_RS29145	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS29150	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS29155	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS29180	COG4636	protein conserved in cyanobacteria
CMC5_RS29200	COG1742	UPF0060 membrane protein
CMC5_RS29240	COG3386	PFAM SMP-30 Gluconolaconase
CMC5_RS29295	COG0437	4 iron, 4 sulfur cluster binding
CMC5_RS29300	COG0243	molybdopterin cofactor binding
CMC5_RS29300	COG3383	formate dehydrogenase (NAD+) activity
CMC5_RS29305	COG0243	molybdopterin cofactor binding
CMC5_RS29305	COG3383	formate dehydrogenase (NAD+) activity
CMC5_RS29345	COG1309	transcriptional regulator
CMC5_RS29370	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CMC5_RS29385	COG0488	(ABC) transporter
CMC5_RS29395	COG2996	Protein conserved in bacteria
CMC5_RS29430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CMC5_RS29435	COG0583	DNA-binding transcription factor activity
CMC5_RS29440	COG1024	Enoyl-CoA hydratase
CMC5_RS29455	COG3507	Belongs to the glycosyl hydrolase 43 family
CMC5_RS29475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CMC5_RS29500	COG0477	Major facilitator Superfamily
CMC5_RS29525	COG0535	radical SAM domain protein
CMC5_RS29550	COG0515	serine threonine protein kinase
CMC5_RS29550	COG2815	serine threonine protein kinase
CMC5_RS29610	COG0270	DNA (cytosine-5-)-methyltransferase activity
CMC5_RS29620	COG1401	restriction endodeoxyribonuclease activity
CMC5_RS29625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CMC5_RS29635	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS29660	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS29675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CMC5_RS29680	COG0436	Aminotransferase
CMC5_RS29700	COG0515	serine threonine protein kinase
CMC5_RS29700	COG2815	serine threonine protein kinase
CMC5_RS29715	COG2032	superoxide dismutase activity
CMC5_RS29720	COG0515	serine threonine protein kinase
CMC5_RS29730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CMC5_RS29755	COG0590	tRNA wobble adenosine to inosine editing
CMC5_RS29760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CMC5_RS29805	COG0037	tRNA processing
CMC5_RS29810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CMC5_RS29835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CMC5_RS29850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CMC5_RS29885	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CMC5_RS29900	COG2199	diguanylate cyclase activity
CMC5_RS29900	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CMC5_RS29905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CMC5_RS29920	COG1965	Belongs to the frataxin family
CMC5_RS29925	COG0546	phosphoglycolate phosphatase activity
CMC5_RS29940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CMC5_RS29940	COG0678	peroxiredoxin activity
CMC5_RS29955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CMC5_RS29960	COG0642	Histidine kinase
CMC5_RS29965	COG0745	RESPONSE REGULATOR receiver
CMC5_RS29985	COG2204	response regulator
CMC5_RS30035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CMC5_RS30040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CMC5_RS30060	COG0215	cysteine-tRNA ligase activity
CMC5_RS30095	COG0477	Major facilitator Superfamily
CMC5_RS30110	COG3631	Ketosteroid isomerase-related protein
CMC5_RS30160	COG0667	Aldo Keto reductase
CMC5_RS30165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CMC5_RS30210	COG0527	aspartate kinase activity
CMC5_RS30215	COG0596	Alpha beta hydrolase
CMC5_RS30220	COG1131	(ABC) transporter
CMC5_RS30240	COG0072	phenylalanine-tRNA ligase activity
CMC5_RS30245	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS30250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CMC5_RS30255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CMC5_RS30260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CMC5_RS30270	COG2885	chlorophyll binding
CMC5_RS30275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CMC5_RS30280	COG0594	ribonuclease P activity
CMC5_RS30290	COG1847	R3H domain protein
CMC5_RS30295	COG0335	large ribosomal subunit rRNA binding
CMC5_RS30310	COG0631	protein serine/threonine phosphatase activity
CMC5_RS30315	COG1716	ATPase activity
CMC5_RS30315	COG1131	(ABC) transporter
CMC5_RS30315	COG0842	Transport permease protein
CMC5_RS30330	COG0514	ATP-dependent DNA helicase (RecQ)
CMC5_RS30335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CMC5_RS30335	COG2205	protein histidine kinase activity
CMC5_RS30350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CMC5_RS30370	COG2204	response regulator
CMC5_RS30375	COG0156	8-amino-7-oxononanoate synthase activity
CMC5_RS30390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CMC5_RS30415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CMC5_RS30420	COG4948	Mandelate Racemase Muconate Lactonizing
CMC5_RS30425	COG0631	protein serine/threonine phosphatase activity
CMC5_RS30440	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS30465	COG2204	response regulator
CMC5_RS30475	COG0109	protoheme IX farnesyltransferase activity
CMC5_RS30475	COG1612	heme a metabolic process
CMC5_RS30485	COG1628	Protein of unknown function DUF99
CMC5_RS30565	COG2234	aminopeptidase activity
CMC5_RS30620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CMC5_RS30625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CMC5_RS30700	COG2204	response regulator
CMC5_RS30705	COG0515	serine threonine protein kinase
CMC5_RS30740	COG0702	epimerase
CMC5_RS30770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CMC5_RS30800	COG0515	serine threonine protein kinase
CMC5_RS30805	COG0515	serine threonine protein kinase
CMC5_RS30845	COG0488	(ABC) transporter
CMC5_RS30905	COG0515	serine threonine protein kinase
CMC5_RS30925	COG0667	Aldo Keto reductase
CMC5_RS30995	COG0644	oxidoreductase
CMC5_RS31085	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS31120	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CMC5_RS31140	COG0702	epimerase
CMC5_RS31150	COG2272	Belongs to the type-B carboxylesterase lipase family
CMC5_RS31165	COG0437	4 iron, 4 sulfur cluster binding
CMC5_RS31210	COG1845	cytochrome c oxidase, subunit III
CMC5_RS31240	COG0515	serine threonine protein kinase
CMC5_RS31240	COG2815	serine threonine protein kinase
CMC5_RS31255	COG2202	Pas domain
CMC5_RS31255	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS31295	COG0709	Synthesizes selenophosphate from selenide and ATP
CMC5_RS31305	COG0534	Mate efflux family protein
CMC5_RS31310	COG4232	protein-disulfide reductase activity
CMC5_RS31320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CMC5_RS31325	COG0277	FAD linked oxidase domain protein
CMC5_RS31330	COG0424	maF-like protein
CMC5_RS31340	COG2132	Multicopper oxidase
CMC5_RS31355	COG2815	serine threonine protein kinase
CMC5_RS31355	COG0515	serine threonine protein kinase
CMC5_RS31385	COG0432	Pfam Uncharacterised protein family UPF0047
CMC5_RS31410	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS31415	COG0625	glutathione transferase activity
CMC5_RS31420	COG0625	glutathione transferase activity
CMC5_RS31440	COG1074	ATP-dependent DNA helicase activity
CMC5_RS31495	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS31525	COG1100	Small GTP-binding protein
CMC5_RS31535	COG1744	ABC transporter substrate-binding protein PnrA-like
CMC5_RS31550	COG1104	cysteine desulfurase activity
CMC5_RS31580	COG0667	Aldo Keto reductase
CMC5_RS31590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CMC5_RS31595	COG0028	Belongs to the TPP enzyme family
CMC5_RS31600	COG0154	amidase activity
CMC5_RS31605	COG1643	Atp-dependent helicase
CMC5_RS31615	COG1605	Chorismate mutase
CMC5_RS31615	COG0077	Prephenate dehydratase
CMC5_RS31625	COG1196	nuclear chromosome segregation
CMC5_RS31635	COG0515	serine threonine protein kinase
CMC5_RS31635	COG0457	Tetratricopeptide repeat
CMC5_RS31650	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS31700	COG0583	DNA-binding transcription factor activity
CMC5_RS31710	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS31720	COG4106	trans-aconitate 2-methyltransferase activity
CMC5_RS31740	COG0372	Belongs to the citrate synthase family
CMC5_RS31745	COG0372	Belongs to the citrate synthase family
CMC5_RS31765	COG1309	transcriptional regulator
CMC5_RS31785	COG4638	Rieske (2fe-2S)
CMC5_RS31815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CMC5_RS31840	COG0617	tRNA 3'-terminal CCA addition
CMC5_RS31845	COG0515	serine threonine protein kinase
CMC5_RS31855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CMC5_RS31865	COG5002	protein histidine kinase activity
CMC5_RS31865	COG2176	DNA-directed DNA polymerase activity
CMC5_RS31905	COG1329	Transcriptional regulator
CMC5_RS31930	COG0571	ribonuclease III activity
CMC5_RS31935	COG2154	pterin-4-alpha-carbinolamine dehydratase
CMC5_RS31965	COG2204	response regulator
CMC5_RS31980	COG4221	oxidoreductase activity
CMC5_RS31995	COG1381	Involved in DNA repair and RecF pathway recombination
CMC5_RS32015	COG1214	PFAM Peptidase M22, glycoprotease
CMC5_RS32040	COG0484	heat shock protein binding
CMC5_RS32045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CMC5_RS32055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CMC5_RS32060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CMC5_RS32065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CMC5_RS32070	COG0772	Belongs to the SEDS family
CMC5_RS32075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CMC5_RS32080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CMC5_RS32085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CMC5_RS32095	COG0275	rRNA processing
CMC5_RS32115	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS32140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CMC5_RS32160	COG1136	(ABC) transporter
CMC5_RS32170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CMC5_RS32175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CMC5_RS32195	COG0515	serine threonine protein kinase
CMC5_RS32220	COG1543	Belongs to the glycosyl hydrolase 57 family
CMC5_RS32225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CMC5_RS32230	COG0181	hydroxymethylbilane synthase activity
CMC5_RS32235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CMC5_RS32240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CMC5_RS32250	COG1183	phosphatidylcholine synthase activity
CMC5_RS32285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CMC5_RS32290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CMC5_RS32360	COG0515	serine threonine protein kinase
CMC5_RS32360	COG2815	serine threonine protein kinase
CMC5_RS32380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CMC5_RS32425	COG0515	serine threonine protein kinase
CMC5_RS32470	COG2815	serine threonine protein kinase
CMC5_RS32470	COG0515	serine threonine protein kinase
CMC5_RS32475	COG2815	serine threonine protein kinase
CMC5_RS32475	COG0515	serine threonine protein kinase
CMC5_RS32485	COG2201	protein-glutamate methylesterase activity
CMC5_RS32490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CMC5_RS32500	COG0835	chemotaxis
CMC5_RS32510	COG0643	Histidine kinase
CMC5_RS32510	COG2198	Histidine kinase
CMC5_RS32515	COG0745	RESPONSE REGULATOR receiver
CMC5_RS32530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CMC5_RS32535	COG2205	protein histidine kinase activity
CMC5_RS32540	COG0745	RESPONSE REGULATOR receiver
CMC5_RS32595	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CMC5_RS32600	COG1132	(ABC) transporter
CMC5_RS32660	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CMC5_RS32670	COG0640	Transcriptional regulator
CMC5_RS32675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CMC5_RS32690	COG0022	dehydrogenase e1 component
CMC5_RS32700	COG4251	negative regulation of phosphorylation
CMC5_RS32715	COG2815	serine threonine protein kinase
CMC5_RS32715	COG0515	serine threonine protein kinase
CMC5_RS32755	COG4221	oxidoreductase activity
CMC5_RS32760	COG0583	DNA-binding transcription factor activity
CMC5_RS32770	COG0604	alcohol dehydrogenase
CMC5_RS32775	COG4941	Belongs to the sigma-70 factor family
CMC5_RS32780	COG3795	YCII-related domain
CMC5_RS32805	COG1309	transcriptional regulator
CMC5_RS32850	COG3469	chitinase activity
CMC5_RS32850	COG3325	Belongs to the glycosyl hydrolase 18 family
CMC5_RS32855	COG3153	acetyltransferase
CMC5_RS32885	COG2378	regulation of single-species biofilm formation
CMC5_RS32890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CMC5_RS32935	COG0656	L-ascorbic acid biosynthetic process
CMC5_RS32940	COG2169	Transcriptional regulator
CMC5_RS32940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CMC5_RS32965	COG0583	DNA-binding transcription factor activity
CMC5_RS32970	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS32985	COG0667	Aldo Keto reductase
CMC5_RS32995	COG2267	carboxylic ester hydrolase activity
CMC5_RS33010	COG2337	Toxic component of a toxin-antitoxin (TA) module
CMC5_RS33020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CMC5_RS33025	COG0604	alcohol dehydrogenase
CMC5_RS33030	COG3795	YCII-related domain
CMC5_RS33090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CMC5_RS33120	COG0488	(ABC) transporter
CMC5_RS33205	COG0438	transferase activity, transferring glycosyl groups
CMC5_RS33210	COG0438	transferase activity, transferring glycosyl groups
CMC5_RS33220	COG1819	glycosyl
CMC5_RS33235	COG2319	Wd-40 repeat
CMC5_RS33235	COG1672	PFAM Archaeal ATPase
CMC5_RS33240	COG0515	serine threonine protein kinase
CMC5_RS33250	COG1690	Belongs to the RtcB family
CMC5_RS33285	COG2814	Major facilitator Superfamily
CMC5_RS33375	COG2192	nodulation
CMC5_RS33400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CMC5_RS33405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CMC5_RS33410	COG0625	glutathione transferase activity
CMC5_RS33445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS33450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CMC5_RS33535	COG0494	nUDIX hydrolase
CMC5_RS33575	COG0515	serine threonine protein kinase
CMC5_RS33575	COG2815	serine threonine protein kinase
CMC5_RS33595	COG2267	carboxylic ester hydrolase activity
CMC5_RS33600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CMC5_RS33665	COG0564	pseudouridine synthase activity
CMC5_RS33680	COG0631	protein serine/threonine phosphatase activity
CMC5_RS33690	COG1546	Belongs to the CinA family
CMC5_RS33690	COG1058	Belongs to the CinA family
CMC5_RS33695	COG1722	exodeoxyribonuclease VII activity
CMC5_RS33760	COG3541	Predicted nucleotidyltransferase
CMC5_RS33780	COG0628	permease
CMC5_RS33795	COG0539	negative regulation of cytoplasmic translation
CMC5_RS33810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CMC5_RS33815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CMC5_RS33855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CMC5_RS33915	COG0515	serine threonine protein kinase
CMC5_RS33930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CMC5_RS33935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CMC5_RS33940	COG0477	Major facilitator Superfamily
CMC5_RS33945	COG2205	protein histidine kinase activity
CMC5_RS34020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CMC5_RS34025	COG2207	Transcriptional regulator
CMC5_RS34030	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS34050	COG2226	methyltransferase
CMC5_RS34135	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CMC5_RS34135	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CMC5_RS34145	COG1045	serine acetyltransferase
CMC5_RS34185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CMC5_RS34190	COG0508	dehydrogenase complex catalyzes the overall conversion of
CMC5_RS34235	COG1132	(ABC) transporter
CMC5_RS34240	COG0784	Response regulator, receiver
CMC5_RS34240	COG2198	Histidine kinase
CMC5_RS34240	COG5002	protein histidine kinase activity
CMC5_RS34245	COG2205	protein histidine kinase activity
CMC5_RS34245	COG0784	Response regulator, receiver
CMC5_RS34320	COG1678	Uncharacterized ACR, COG1678
CMC5_RS34340	COG0598	Magnesium transport protein CorA
CMC5_RS34345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CMC5_RS34360	COG1131	(ABC) transporter
CMC5_RS34365	COG2815	serine threonine protein kinase
CMC5_RS34365	COG0515	serine threonine protein kinase
CMC5_RS34375	COG0631	protein serine/threonine phosphatase activity
CMC5_RS34400	COG2766	serine protein kinase
CMC5_RS34415	COG0009	L-threonylcarbamoyladenylate synthase
CMC5_RS34425	COG0305	Participates in initiation and elongation during chromosome replication
CMC5_RS34430	COG0359	binds to the 23S rRNA
CMC5_RS34435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CMC5_RS34440	COG0360	Binds together with S18 to 16S ribosomal RNA
CMC5_RS34445	COG0193	aminoacyl-tRNA hydrolase activity
CMC5_RS34450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CMC5_RS34455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CMC5_RS34460	COG0196	riboflavin kinase activity
CMC5_RS34490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CMC5_RS34525	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS34530	COG0189	ligase activity
CMC5_RS34535	COG1024	Enoyl-CoA hydratase
CMC5_RS34555	COG0515	serine threonine protein kinase
CMC5_RS34585	COG0625	glutathione transferase activity
CMC5_RS34605	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS34615	COG0823	Involved in the tonB-independent uptake of proteins
CMC5_RS34640	COG2885	chlorophyll binding
CMC5_RS34640	COG3047	cAMP biosynthetic process
CMC5_RS34645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CMC5_RS34725	COG0179	Fumarylacetoacetate (FAA) hydrolase
CMC5_RS34745	COG1595	DNA-templated transcription, initiation
CMC5_RS34765	COG1597	lipid kinase activity
CMC5_RS34770	COG1605	Chorismate mutase
CMC5_RS34770	COG0287	Prephenate dehydrogenase
CMC5_RS34780	COG0826	peptidase U32
CMC5_RS34875	COG2072	flavoprotein involved in K transport
CMC5_RS34880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CMC5_RS34885	COG4266	Belongs to the allantoicase family
CMC5_RS34895	COG2351	hydroxyisourate hydrolase activity
CMC5_RS34905	COG3268	Saccharopine dehydrogenase
CMC5_RS34910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CMC5_RS34935	COG1902	pentaerythritol trinitrate reductase activity
CMC5_RS34940	COG1674	ftsk spoiiie
CMC5_RS34965	COG1393	Belongs to the ArsC family
CMC5_RS35020	COG0488	(ABC) transporter
CMC5_RS35040	COG4249	Peptidase C14 caspase catalytic subunit p20
CMC5_RS35040	COG2319	Wd-40 repeat
CMC5_RS35055	COG2204	response regulator
CMC5_RS35060	COG1953	Uracil, thiamine, allantoin
CMC5_RS35070	COG0493	'glutamate synthase
CMC5_RS35075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CMC5_RS35085	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS35090	COG0861	Integral membrane protein TerC family
CMC5_RS35100	COG0745	RESPONSE REGULATOR receiver
CMC5_RS35115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CMC5_RS35155	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS35175	COG2815	serine threonine protein kinase
CMC5_RS35175	COG0515	serine threonine protein kinase
CMC5_RS35235	COG0586	Pfam SNARE associated Golgi protein
CMC5_RS35240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CMC5_RS35245	COG0438	transferase activity, transferring glycosyl groups
CMC5_RS35250	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS35250	COG2202	Pas domain
CMC5_RS35265	COG2205	protein histidine kinase activity
CMC5_RS35265	COG0784	Response regulator, receiver
CMC5_RS35270	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS35325	COG0277	FAD linked oxidase domain protein
CMC5_RS35345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS35375	COG0515	serine threonine protein kinase
CMC5_RS35375	COG2815	serine threonine protein kinase
CMC5_RS35380	COG1012	belongs to the aldehyde dehydrogenase family
CMC5_RS35385	COG1360	Flagellar Motor Protein
CMC5_RS35395	COG2814	Major facilitator Superfamily
CMC5_RS35425	COG1051	belongs to the nudix hydrolase family
CMC5_RS35445	COG1490	D-aminoacyl-tRNA deacylase activity
CMC5_RS35455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CMC5_RS35460	COG0745	RESPONSE REGULATOR receiver
CMC5_RS35465	COG0312	modulator of DNA gyrase
CMC5_RS35520	COG0793	Belongs to the peptidase S41A family
CMC5_RS35610	COG1858	cytochrome C peroxidase
CMC5_RS35620	COG0443	Heat shock 70 kDa protein
CMC5_RS35630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS35635	COG2205	protein histidine kinase activity
CMC5_RS35645	COG2353	YceI-like domain
CMC5_RS35660	COG1331	Highly conserved protein containing a thioredoxin domain
CMC5_RS35665	COG2267	carboxylic ester hydrolase activity
CMC5_RS35670	COG2207	Transcriptional regulator
CMC5_RS35675	COG1064	alcohol dehydrogenase
CMC5_RS35680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CMC5_RS35685	COG1741	Belongs to the pirin family
CMC5_RS35690	COG1073	alpha beta
CMC5_RS35725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CMC5_RS35740	COG1376	ErfK ybiS ycfS ynhG family protein
CMC5_RS35780	COG2205	protein histidine kinase activity
CMC5_RS35805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CMC5_RS35810	COG0277	FAD linked oxidase domain protein
CMC5_RS35820	COG1525	nuclease
CMC5_RS35820	COG4085	toxin activity
CMC5_RS35820	COG0737	Belongs to the 5'-nucleotidase family
CMC5_RS35825	COG0604	alcohol dehydrogenase
CMC5_RS35825	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS35825	COG3321	synthase
CMC5_RS35880	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CMC5_RS35885	COG0714	Associated with various cellular activities
CMC5_RS35905	COG2072	flavoprotein involved in K transport
CMC5_RS35910	COG0116	Belongs to the methyltransferase superfamily
CMC5_RS35910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CMC5_RS35960	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS35980	COG2885	chlorophyll binding
CMC5_RS35985	COG1606	tRNA processing
CMC5_RS35995	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS36010	COG2304	oxidoreductase activity
CMC5_RS36015	COG0515	serine threonine protein kinase
CMC5_RS36015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS36025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CMC5_RS36030	COG0484	heat shock protein binding
CMC5_RS36035	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS36050	COG0745	RESPONSE REGULATOR receiver
CMC5_RS36055	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS36100	COG1595	DNA-templated transcription, initiation
CMC5_RS36115	COG0295	cytidine deaminase activity
CMC5_RS36120	COG0745	RESPONSE REGULATOR receiver
CMC5_RS36125	COG0205	6-phosphofructokinase activity
CMC5_RS36130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CMC5_RS36135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CMC5_RS36150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CMC5_RS36185	COG1024	Enoyl-CoA hydratase
CMC5_RS36215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CMC5_RS36240	COG2264	protein methyltransferase activity
CMC5_RS36255	COG1253	flavin adenine dinucleotide binding
CMC5_RS36260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CMC5_RS36270	COG2304	oxidoreductase activity
CMC5_RS36285	COG0714	Associated with various cellular activities
CMC5_RS36300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CMC5_RS36310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CMC5_RS36315	COG0459	protein refolding
CMC5_RS36330	COG0017	Asparaginyl-tRNA synthetase
CMC5_RS36370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CMC5_RS36375	COG1024	Enoyl-CoA hydratase
CMC5_RS36395	COG0714	Associated with various cellular activities
CMC5_RS36400	COG0588	phosphoglycerate mutase activity
CMC5_RS36420	COG0564	pseudouridine synthase activity
CMC5_RS36520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CMC5_RS36525	COG1160	GTP binding
CMC5_RS36535	COG2894	cell division
CMC5_RS36555	COG0515	serine threonine protein kinase
CMC5_RS36565	COG2322	membrane
CMC5_RS36585	COG0110	maltose O-acetyltransferase activity
CMC5_RS36645	COG1695	Transcriptional regulator
CMC5_RS36670	COG1918	ferrous iron import across plasma membrane
CMC5_RS36670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CMC5_RS36690	COG1966	Carbon starvation protein
CMC5_RS36695	COG2879	small protein
CMC5_RS36700	COG2311	Membrane
CMC5_RS36745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CMC5_RS36745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CMC5_RS36750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CMC5_RS36755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CMC5_RS36760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CMC5_RS36765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CMC5_RS36775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CMC5_RS36800	COG2815	serine threonine protein kinase
CMC5_RS36800	COG0515	serine threonine protein kinase
CMC5_RS36805	COG0346	lactoylglutathione lyase activity
CMC5_RS36815	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CMC5_RS36815	COG0515	serine threonine protein kinase
CMC5_RS36835	COG0515	serine threonine protein kinase
CMC5_RS36845	COG0435	Glutathione S-transferase
CMC5_RS36855	COG3848	Pyruvate phosphate dikinase
CMC5_RS36855	COG0574	Belongs to the PEP-utilizing enzyme family
CMC5_RS36990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CMC5_RS36995	COG0420	3'-5' exonuclease activity
CMC5_RS37005	COG4221	oxidoreductase activity
CMC5_RS37045	COG1597	lipid kinase activity
CMC5_RS37050	COG0515	serine threonine protein kinase
CMC5_RS37050	COG2815	serine threonine protein kinase
CMC5_RS37060	COG4717	serine-type aminopeptidase activity
CMC5_RS37065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS37070	COG0438	transferase activity, transferring glycosyl groups
CMC5_RS37135	COG1213	nucleotidyl transferase
CMC5_RS37135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CMC5_RS37150	COG0347	Belongs to the P(II) protein family
CMC5_RS37160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CMC5_RS37165	COG2202	Pas domain
CMC5_RS37165	COG2205	protein histidine kinase activity
CMC5_RS37175	COG2255	four-way junction helicase activity
CMC5_RS37185	COG4191	Histidine kinase
CMC5_RS37200	COG1595	DNA-templated transcription, initiation
CMC5_RS37205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CMC5_RS37220	COG1047	Peptidyl-prolyl cis-trans
CMC5_RS37230	COG1136	(ABC) transporter
CMC5_RS37230	COG0577	efflux transmembrane transporter activity
CMC5_RS37235	COG1136	(ABC) transporter
CMC5_RS37235	COG0577	efflux transmembrane transporter activity
CMC5_RS37240	COG1136	(ABC) transporter
CMC5_RS37240	COG0577	efflux transmembrane transporter activity
CMC5_RS37245	COG0539	negative regulation of cytoplasmic translation
CMC5_RS37250	COG0489	protein tyrosine kinase activity
CMC5_RS37310	COG1100	Small GTP-binding protein
CMC5_RS37330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CMC5_RS37340	COG0528	UMP kinase activity
CMC5_RS37350	COG1509	lysine 2,3-aminomutase activity
CMC5_RS37355	COG0457	Tetratricopeptide repeat
CMC5_RS37355	COG0515	serine threonine protein kinase
CMC5_RS37365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CMC5_RS37395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CMC5_RS37395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CMC5_RS37400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CMC5_RS37405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CMC5_RS37410	COG1193	negative regulation of DNA recombination
CMC5_RS37415	COG2204	response regulator
CMC5_RS37425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CMC5_RS37435	COG0681	Belongs to the peptidase S26 family
CMC5_RS37445	COG1063	alcohol dehydrogenase
CMC5_RS37455	COG0156	8-amino-7-oxononanoate synthase activity
CMC5_RS37535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CMC5_RS37540	COG0037	tRNA processing
CMC5_RS37550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CMC5_RS37555	COG0515	serine threonine protein kinase
CMC5_RS37565	COG0482	sulfurtransferase activity
CMC5_RS37570	COG0745	RESPONSE REGULATOR receiver
CMC5_RS37580	COG0047	phosphoribosylformylglycinamidine synthase activity
CMC5_RS37610	COG0793	Belongs to the peptidase S41A family
CMC5_RS37625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CMC5_RS37660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CMC5_RS37670	COG3597	protein domain associated with
CMC5_RS37690	COG0515	serine threonine protein kinase
CMC5_RS37690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CMC5_RS37695	COG2204	response regulator
CMC5_RS37830	COG2957	Belongs to the agmatine deiminase family
CMC5_RS37880	COG0351	phosphomethylpyrimidine kinase
CMC5_RS37880	COG0352	thiamine-phosphate diphosphorylase activity
CMC5_RS37915	COG2885	chlorophyll binding
CMC5_RS37930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CMC5_RS37935	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS37945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CMC5_RS37970	COG1053	succinate dehydrogenase
CMC5_RS38020	COG0714	Associated with various cellular activities
CMC5_RS38035	COG2304	oxidoreductase activity
CMC5_RS38065	COG0723	plastoquinol--plastocyanin reductase activity
CMC5_RS38065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CMC5_RS38090	COG0583	DNA-binding transcription factor activity
CMC5_RS38130	COG0604	alcohol dehydrogenase
CMC5_RS38270	COG3436	PFAM IS66 Orf2 family protein
CMC5_RS38275	COG4372	Transposase
CMC5_RS38320	COG1028	Short-chain dehydrogenase reductase Sdr
CMC5_RS38330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CMC5_RS38330	COG2010	Cytochrome c
CMC5_RS38335	COG2080	2 iron, 2 sulfur cluster binding
CMC5_RS38350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CMC5_RS38360	COG1309	transcriptional regulator
CMC5_RS38370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CMC5_RS38375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CMC5_RS38390	COG0556	nucleotide-excision repair
CMC5_RS38400	COG4191	Histidine kinase
CMC5_RS38420	COG3214	Protein conserved in bacteria
CMC5_RS38425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CMC5_RS38445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CMC5_RS38470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CMC5_RS38485	COG1902	pentaerythritol trinitrate reductase activity
CMC5_RS38500	COG1595	DNA-templated transcription, initiation
CMC5_RS38505	COG0427	acetyl-CoA hydrolase
CMC5_RS38515	COG0069	glutamate synthase activity
CMC5_RS38515	COG0067	glutamate synthase
CMC5_RS38515	COG0070	glutamate synthase
CMC5_RS38520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CMC5_RS38540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CMC5_RS38555	COG1193	negative regulation of DNA recombination
CMC5_RS38575	COG0604	alcohol dehydrogenase
CMC5_RS38585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CMC5_RS38590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CMC5_RS38600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CMC5_RS38605	COG2815	serine threonine protein kinase
CMC5_RS38605	COG0515	serine threonine protein kinase
CMC5_RS38615	COG0515	serine threonine protein kinase
CMC5_RS38615	COG2815	serine threonine protein kinase
CMC5_RS38645	COG3318	Belongs to the UPF0149 family
CMC5_RS38645	COG3012	SEC-C Motif Domain Protein
CMC5_RS38695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CMC5_RS38705	COG0840	transmembrane signaling receptor activity
CMC5_RS38715	COG2201	protein-glutamate methylesterase activity
CMC5_RS38720	COG0745	RESPONSE REGULATOR receiver
CMC5_RS38725	COG2130	NADP-dependent
CMC5_RS38730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CMC5_RS38745	COG2208	phosphoserine phosphatase activity
CMC5_RS38745	COG2770	Histidine kinase
CMC5_RS38760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CMC5_RS38765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CMC5_RS38770	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS38780	COG0625	glutathione transferase activity
CMC5_RS38790	COG0745	RESPONSE REGULATOR receiver
CMC5_RS38795	COG2205	protein histidine kinase activity
CMC5_RS38815	COG4122	O-methyltransferase activity
CMC5_RS38820	COG0667	Aldo Keto reductase
CMC5_RS38855	COG1024	Enoyl-CoA hydratase
CMC5_RS38860	COG0515	serine threonine protein kinase
CMC5_RS38860	COG4991	sh3 domain protein
CMC5_RS38860	COG3064	Membrane
CMC5_RS38880	COG2815	serine threonine protein kinase
CMC5_RS38880	COG0515	serine threonine protein kinase
CMC5_RS38885	COG4771	TonB-dependent receptor
CMC5_RS38900	COG3501	Rhs element vgr protein
CMC5_RS38935	COG0515	serine threonine protein kinase
CMC5_RS38935	COG2815	serine threonine protein kinase
CMC5_RS39040	COG0745	RESPONSE REGULATOR receiver
CMC5_RS39045	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CMC5_RS39135	COG3293	Transposase
CMC5_RS39210	COG2271	Major facilitator Superfamily
CMC5_RS39225	COG0183	Belongs to the thiolase family
CMC5_RS39230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CMC5_RS39250	COG0318	PFAM AMP-dependent synthetase and ligase
CMC5_RS39275	COG1716	ATPase activity
CMC5_RS39280	COG0515	serine threonine protein kinase
CMC5_RS39280	COG0457	Tetratricopeptide repeat
CMC5_RS39295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CMC5_RS39320	COG1773	rubredoxin
CMC5_RS39335	COG5487	UPF0391 membrane protein
CMC5_RS39340	COG0667	Aldo Keto reductase
CMC5_RS39345	COG0667	Aldo Keto reductase
CMC5_RS39445	COG1192	Involved in chromosome partitioning
CMC5_RS39475	COG1309	transcriptional regulator
CMC5_RS39495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CMC5_RS39500	COG2264	protein methyltransferase activity
CMC5_RS39505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CMC5_RS39510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CMC5_RS39530	COG0038	chloride channel
CMC5_RS39535	COG2308	Evidence 4 Homologs of previously reported genes of
CMC5_RS39595	COG3781	membrane
CMC5_RS39605	COG0640	Transcriptional regulator
CMC5_RS39615	COG0542	response to heat
CMC5_RS39620	COG0542	response to heat
CMC5_RS39630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CMC5_RS39635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CMC5_RS39640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CMC5_RS39645	COG0649	NAD binding
CMC5_RS39650	COG1034	ATP synthesis coupled electron transport
CMC5_RS39655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CMC5_RS39665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CMC5_RS39710	COG0247	lactate metabolic process
CMC5_RS39710	COG2181	nitrate reductase activity
CMC5_RS39750	COG0702	epimerase
CMC5_RS39765	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CMC5_RS39770	COG3052	prosthetic group binding
CMC5_RS39800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CMC5_RS39850	COG4257	antibiotic catabolic process
CMC5_RS39905	COG2815	serine threonine protein kinase
CMC5_RS39905	COG0515	serine threonine protein kinase
CMC5_RS39920	COG2205	protein histidine kinase activity
CMC5_RS39940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CMC5_RS39950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CMC5_RS39965	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CMC5_RS39980	COG1845	cytochrome c oxidase, subunit III
CMC5_RS40025	COG0437	4 iron, 4 sulfur cluster binding
CMC5_RS40055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CMC5_RS40055	COG1672	PFAM Archaeal ATPase
CMC5_RS40090	COG1408	metallophosphoesterase
CMC5_RS40105	COG0745	RESPONSE REGULATOR receiver
CMC5_RS40110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CMC5_RS40110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CMC5_RS40140	COG0189	ligase activity
CMC5_RS40145	COG0405	Gamma-glutamyltransferase
CMC5_RS40155	COG1595	DNA-templated transcription, initiation
CMC5_RS40160	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CMC5_RS40165	COG1120	ATPase activity
CMC5_RS40170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CMC5_RS40190	COG1024	Enoyl-CoA hydratase
CMC5_RS40190	COG1250	3-hydroxyacyl-CoA dehydrogenase
CMC5_RS40195	COG0183	Belongs to the thiolase family
CMC5_RS40200	COG2716	regulation of RNA biosynthetic process
CMC5_RS40220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CMC5_RS40220	COG2205	protein histidine kinase activity
CMC5_RS40225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CMC5_RS40245	COG2226	methyltransferase
CMC5_RS40285	COG1505	serine-type exopeptidase activity
CMC5_RS40310	COG2885	chlorophyll binding
CMC5_RS40315	COG0737	Belongs to the 5'-nucleotidase family
CMC5_RS40335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CMC5_RS40345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS40380	COG2815	serine threonine protein kinase
CMC5_RS40380	COG0515	serine threonine protein kinase
CMC5_RS40385	COG1063	alcohol dehydrogenase
CMC5_RS40395	COG3387	PFAM Glycoside hydrolase 15-related
CMC5_RS40450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CMC5_RS40465	COG0443	Heat shock 70 kDa protein
CMC5_RS40470	COG0254	rRNA binding
CMC5_RS40475	COG3872	metal-dependent enzyme
CMC5_RS40480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CMC5_RS40490	COG0537	adenosine 5'-monophosphoramidase activity
CMC5_RS40495	COG0277	FAD linked oxidase domain protein
CMC5_RS40550	COG0515	serine threonine protein kinase
CMC5_RS40555	COG2204	response regulator
CMC5_RS40585	COG1250	3-hydroxyacyl-CoA dehydrogenase
CMC5_RS40595	COG0557	exoribonuclease II activity
CMC5_RS40620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CMC5_RS40630	COG0006	proline dipeptidase activity
CMC5_RS40645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CMC5_RS40715	COG0673	inositol 2-dehydrogenase activity
CMC5_RS40745	COG2226	methyltransferase
CMC5_RS40780	COG0500	methyltransferase
CMC5_RS40805	COG2131	deaminase
CMC5_RS40820	COG0148	phosphopyruvate hydratase activity
CMC5_RS40835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CMC5_RS40855	COG2205	protein histidine kinase activity
CMC5_RS40865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CMC5_RS40865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CMC5_RS40870	COG3608	succinylglutamate desuccinylase aspartoacylase
CMC5_RS40870	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CMC5_RS40875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CMC5_RS40880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CMC5_RS40885	COG2080	2 iron, 2 sulfur cluster binding
CMC5_RS40905	COG0515	serine threonine protein kinase
CMC5_RS40925	COG2095	MarC family integral membrane protein
CMC5_RS40935	COG2267	carboxylic ester hydrolase activity
CMC5_RS40935	COG2226	methyltransferase
CMC5_RS40940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS40945	COG4591	ABC-type transport system involved in lipoprotein release permease component
CMC5_RS40945	COG1136	(ABC) transporter
CMC5_RS40950	COG1136	(ABC) transporter
CMC5_RS40950	COG0577	efflux transmembrane transporter activity
CMC5_RS40970	COG1366	Belongs to the anti-sigma-factor antagonist family
CMC5_RS40980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS40985	COG0443	Heat shock 70 kDa protein
CMC5_RS41030	COG2363	Small membrane protein
CMC5_RS41035	COG0673	inositol 2-dehydrogenase activity
CMC5_RS41045	COG1397	ADP-ribosylglycohydrolase
CMC5_RS41105	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS41110	COG1960	acyl-CoA dehydrogenase activity
CMC5_RS41120	COG0542	response to heat
CMC5_RS41165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CMC5_RS41180	COG2311	Membrane
CMC5_RS41200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CMC5_RS41205	COG2815	serine threonine protein kinase
CMC5_RS41205	COG0515	serine threonine protein kinase
CMC5_RS41230	COG0326	Molecular chaperone. Has ATPase activity
CMC5_RS41240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CMC5_RS41260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CMC5_RS41285	COG1024	Enoyl-CoA hydratase
CMC5_RS41290	COG1250	3-hydroxyacyl-CoA dehydrogenase
CMC5_RS41305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CMC5_RS41310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CMC5_RS41335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CMC5_RS41340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CMC5_RS41345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CMC5_RS41370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CMC5_RS41370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CMC5_RS41375	COG1595	DNA-templated transcription, initiation
CMC5_RS41390	COG1074	ATP-dependent DNA helicase activity
CMC5_RS41395	COG1309	transcriptional regulator
CMC5_RS41420	COG0863	Belongs to the N(4) N(6)-methyltransferase family
CMC5_RS41430	COG0009	L-threonylcarbamoyladenylate synthase
CMC5_RS41435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CMC5_RS41440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CMC5_RS41445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CMC5_RS41450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)