locus-tag	class	description
EG338_RS00010	COG0308	aminopeptidase N
EG338_RS00050	COG5002	protein histidine kinase activity
EG338_RS00055	COG0745	RESPONSE REGULATOR receiver
EG338_RS00075	COG2732	(Barnase) inhibitor
EG338_RS00085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EG338_RS00100	COG0626	cystathionine gamma-synthase activity
EG338_RS00120	COG4628	conserved protein (DUF2132)
EG338_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
EG338_RS00130	COG1506	peptidase
EG338_RS00130	COG0823	Involved in the tonB-independent uptake of proteins
EG338_RS00135	COG2353	YceI-like domain
EG338_RS00140	COG3384	dioxygenase
EG338_RS00150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EG338_RS00170	COG0322	excinuclease ABC activity
EG338_RS00175	COG2986	histidine ammonia-lyase
EG338_RS00245	COG1012	belongs to the aldehyde dehydrogenase family
EG338_RS00250	COG1132	(ABC) transporter
EG338_RS00255	COG0101	tRNA pseudouridine synthase activity
EG338_RS00270	COG0248	Ppx GppA phosphatase
EG338_RS00275	COG0295	cytidine deaminase activity
EG338_RS00290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EG338_RS00300	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EG338_RS00320	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
EG338_RS00330	COG1045	serine acetyltransferase
EG338_RS00340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EG338_RS00360	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG338_RS00380	COG0415	Belongs to the DNA photolyase family
EG338_RS00410	COG1233	COG1233 Phytoene dehydrogenase and related
EG338_RS00425	COG0443	Heat shock 70 kDa protein
EG338_RS00430	COG4654	Cytochrome c, class I
EG338_RS00460	COG1131	(ABC) transporter
EG338_RS00470	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EG338_RS00485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EG338_RS00500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EG338_RS00500	COG0617	tRNA 3'-terminal CCA addition
EG338_RS00500	COG0517	IMP dehydrogenase activity
EG338_RS00605	COG4974	Belongs to the 'phage' integrase family
EG338_RS00610	COG0517	IMP dehydrogenase activity
EG338_RS00680	COG4974	Belongs to the 'phage' integrase family
EG338_RS00685	COG0517	IMP dehydrogenase activity
EG338_RS00700	COG4974	Belongs to the 'phage' integrase family
EG338_RS00705	COG0517	IMP dehydrogenase activity
EG338_RS00765	COG4974	Belongs to the 'phage' integrase family
EG338_RS00875	COG0739	heme binding
EG338_RS00920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EG338_RS00925	COG0537	adenosine 5'-monophosphoramidase activity
EG338_RS00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EG338_RS00940	COG1490	D-aminoacyl-tRNA deacylase activity
EG338_RS00950	COG0596	Alpha beta hydrolase
EG338_RS00950	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG338_RS00960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EG338_RS00965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EG338_RS00970	COG2884	Cell division ATP-binding protein ftsE
EG338_RS00975	COG0825	malonyl-CoA metabolic process
EG338_RS00980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EG338_RS00985	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EG338_RS00985	COG0662	Cupin 2, conserved barrel domain protein
EG338_RS01005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EG338_RS01010	COG0439	Biotin carboxylase
EG338_RS01015	COG0511	ligase activity, forming carbon-carbon bonds
EG338_RS01020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EG338_RS01030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EG338_RS01040	COG5000	phosphorelay sensor kinase activity
EG338_RS01055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EG338_RS01065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EG338_RS01095	COG2261	transglycosylase associated protein
EG338_RS01100	COG0552	protein localization to endoplasmic reticulum
EG338_RS01120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EG338_RS01125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EG338_RS01130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EG338_RS01135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EG338_RS01140	COG0436	Aminotransferase
EG338_RS01145	COG0339	signal peptide processing
EG338_RS01170	COG1704	LemA family
EG338_RS01175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EG338_RS01185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EG338_RS01190	COG1193	negative regulation of DNA recombination
EG338_RS01205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EG338_RS01220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EG338_RS01225	COG1181	Belongs to the D-alanine--D-alanine ligase family
EG338_RS01230	COG1663	tetraacyldisaccharide 4'-kinase activity
EG338_RS01245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG338_RS01275	COG1064	alcohol dehydrogenase
EG338_RS01290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG338_RS01300	COG2808	Putative FMN-binding domain
EG338_RS01310	COG2255	four-way junction helicase activity
EG338_RS01325	COG3460	Phenylacetate-CoA oxygenase
EG338_RS01340	COG2151	metal-sulfur cluster biosynthetic enzyme
EG338_RS01345	COG1024	Enoyl-CoA hydratase
EG338_RS01355	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG338_RS01375	COG1595	DNA-templated transcription, initiation
EG338_RS01395	COG0516	GMP reductase activity
EG338_RS01395	COG0517	IMP dehydrogenase activity
EG338_RS01415	COG0612	Peptidase, M16
EG338_RS01420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG338_RS01450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EG338_RS01455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EG338_RS01460	COG0052	Belongs to the universal ribosomal protein uS2 family
EG338_RS01465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EG338_RS01495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EG338_RS01510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EG338_RS01515	COG1053	succinate dehydrogenase
EG338_RS01525	COG2333	competence protein COMEC
EG338_RS01525	COG0658	competence protein
EG338_RS01530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG338_RS01550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EG338_RS01555	COG4680	protein conserved in bacteria
EG338_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
EG338_RS01580	COG2030	dehydratase
EG338_RS01595	COG0148	phosphopyruvate hydratase activity
EG338_RS01605	COG0203	ribosomal protein L17
EG338_RS01610	COG0202	RNA polymerase activity
EG338_RS01615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EG338_RS01620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EG338_RS01625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EG338_RS01635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EG338_RS01640	COG0201	protein transport
EG338_RS01645	COG0200	Binds to the 23S rRNA
EG338_RS01650	COG1841	ribosomal large subunit assembly
EG338_RS01655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EG338_RS01660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EG338_RS01665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EG338_RS01670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EG338_RS01675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EG338_RS01680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EG338_RS01690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EG338_RS01695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EG338_RS01700	COG0255	Belongs to the universal ribosomal protein uL29 family
EG338_RS01705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EG338_RS01710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EG338_RS01715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EG338_RS01720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EG338_RS01725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EG338_RS01730	COG0089	rRNA binding
EG338_RS01735	COG0088	Forms part of the polypeptide exit tunnel
EG338_RS01740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EG338_RS01750	COG0051	transcription antitermination factor activity, RNA binding
EG338_RS01755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EG338_RS01760	COG0049	tRNA binding
EG338_RS01765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EG338_RS01780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EG338_RS01790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG338_RS01825	COG0254	rRNA binding
EG338_RS01835	COG1694	Mazg nucleotide pyrophosphohydrolase
EG338_RS01840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EG338_RS01845	COG0300	oxidoreductase activity
EG338_RS01850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EG338_RS01860	COG1410	methionine synthase
EG338_RS01860	COG0646	methionine synthase
EG338_RS01870	COG0460	homoserine dehydrogenase
EG338_RS01870	COG0527	aspartate kinase activity
EG338_RS01875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EG338_RS01895	COG0217	transcriptional regulatory protein
EG338_RS01900	COG2885	chlorophyll binding
EG338_RS01905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EG338_RS01910	COG0488	(ABC) transporter
EG338_RS01915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EG338_RS01915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EG338_RS01930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EG338_RS01940	COG0268	Binds directly to 16S ribosomal RNA
EG338_RS01950	COG0860	N-Acetylmuramoyl-L-alanine amidase
EG338_RS01950	COG1388	LysM domain
EG338_RS01960	COG0251	oxidation-reduction process
EG338_RS01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EG338_RS01975	COG1834	amidinotransferase
EG338_RS01995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EG338_RS02090	COG0495	leucyl-tRNA aminoacylation
EG338_RS02105	COG1519	Transferase
EG338_RS02105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EG338_RS02130	COG0037	tRNA processing
EG338_RS02245	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EG338_RS02260	COG0791	NLP P60 protein
EG338_RS02260	COG1388	LysM domain
EG338_RS02265	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EG338_RS02280	COG4771	TonB-dependent receptor
EG338_RS02290	COG4771	TonB-dependent receptor
EG338_RS02295	COG4771	TonB-dependent receptor
EG338_RS02300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EG338_RS02310	COG0779	Required for maturation of 30S ribosomal subunits
EG338_RS02340	COG1216	Glycosyl transferase, family 2
EG338_RS02380	COG0463	Glycosyl transferase, family 2
EG338_RS02385	COG0463	Glycosyl transferase, family 2
EG338_RS02395	COG1215	transferase activity, transferring glycosyl groups
EG338_RS02400	COG2755	lipolytic protein G-D-S-L family
EG338_RS02400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EG338_RS02425	COG0110	maltose O-acetyltransferase activity
EG338_RS02430	COG0288	reversible hydration of carbon dioxide
EG338_RS02440	COG0659	secondary active sulfate transmembrane transporter activity
EG338_RS02455	COG0193	aminoacyl-tRNA hydrolase activity
EG338_RS02460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EG338_RS02495	COG2076	Multidrug Resistance protein
EG338_RS02505	COG0305	Participates in initiation and elongation during chromosome replication
EG338_RS02510	COG0328	RNA-DNA hybrid ribonuclease activity
EG338_RS02515	COG0778	Nitroreductase
EG338_RS02540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EG338_RS02545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EG338_RS02570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EG338_RS02575	COG1611	Belongs to the LOG family
EG338_RS02605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EG338_RS02620	COG1132	(ABC) transporter
EG338_RS02635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EG338_RS02670	COG0813	purine-nucleoside phosphorylase activity
EG338_RS02675	COG0519	Catalyzes the synthesis of GMP from XMP
EG338_RS02685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EG338_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
EG338_RS02710	COG2321	neutral zinc metallopeptidase
EG338_RS02715	COG1368	sulfuric ester hydrolase activity
EG338_RS02720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EG338_RS02760	COG0437	4 iron, 4 sulfur cluster binding
EG338_RS02765	COG3474	cytochrome
EG338_RS02805	COG0463	Glycosyl transferase, family 2
EG338_RS02815	COG0343	queuine tRNA-ribosyltransferase activity
EG338_RS02825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EG338_RS02825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EG338_RS02830	COG0799	negative regulation of ribosome biogenesis
EG338_RS02835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG338_RS02845	COG4589	Belongs to the CDS family
EG338_RS02850	COG0688	phosphatidylethanolamine metabolic process
EG338_RS02860	COG2081	HI0933 family
EG338_RS02870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EG338_RS02880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EG338_RS02910	COG3033	Beta-eliminating lyase
EG338_RS02915	COG3609	addiction module antidote protein, CC2985 family
EG338_RS02935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EG338_RS02940	COG0492	ferredoxin-NADP+ reductase activity
EG338_RS02960	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EG338_RS02990	COG0628	permease
EG338_RS03005	COG0556	nucleotide-excision repair
EG338_RS03015	COG2133	pyrroloquinoline quinone binding
EG338_RS03025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EG338_RS03030	COG0191	fructose-bisphosphate aldolase activity
EG338_RS03035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EG338_RS03045	COG0697	spore germination
EG338_RS03050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EG338_RS03075	COG0539	negative regulation of cytoplasmic translation
EG338_RS03075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EG338_RS03195	COG0653	protein targeting
EG338_RS03200	COG1940	carbohydrate kinase activity
EG338_RS03205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS03210	COG3591	Belongs to the peptidase S1B family
EG338_RS03220	COG2153	protein acetylation
EG338_RS03225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EG338_RS03230	COG2267	carboxylic ester hydrolase activity
EG338_RS03235	COG2001	Belongs to the MraZ family
EG338_RS03240	COG0275	rRNA processing
EG338_RS03250	COG0768	penicillin binding
EG338_RS03255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EG338_RS03260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EG338_RS03265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EG338_RS03270	COG0772	Belongs to the SEDS family
EG338_RS03275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EG338_RS03280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EG338_RS03295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EG338_RS03300	COG1610	YqeY-like protein
EG338_RS03335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EG338_RS03340	COG1505	serine-type exopeptidase activity
EG338_RS03355	COG0700	Nucleoside recognition
EG338_RS03375	COG0662	Cupin 2, conserved barrel domain protein
EG338_RS03375	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EG338_RS03385	COG2166	iron-sulfur cluster assembly
EG338_RS03400	COG0542	response to heat
EG338_RS03405	COG0590	tRNA wobble adenosine to inosine editing
EG338_RS03415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EG338_RS03420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EG338_RS03435	COG1774	PSP1 C-terminal conserved region
EG338_RS03445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EG338_RS03450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EG338_RS03460	COG2032	superoxide dismutase activity
EG338_RS03475	COG0482	sulfurtransferase activity
EG338_RS03480	COG3279	Response regulator of the LytR AlgR family
EG338_RS03495	COG0793	Belongs to the peptidase S41A family
EG338_RS03500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EG338_RS03530	COG0247	lactate metabolic process
EG338_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
EG338_RS03570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EG338_RS03575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EG338_RS03585	COG1435	thymidine kinase activity
EG338_RS03600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EG338_RS03605	COG0445	tRNA wobble uridine modification
EG338_RS03615	COG0126	phosphoglycerate kinase activity
EG338_RS03620	COG0698	ribose 5-phosphate isomerase
EG338_RS03625	COG0557	exoribonuclease II activity
EG338_RS03635	COG1619	proteins homologs of microcin C7 resistance protein MccF
EG338_RS03640	COG0792	nuclease activity
EG338_RS03645	COG4221	oxidoreductase activity
EG338_RS03650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EG338_RS03660	COG0424	maF-like protein
EG338_RS03665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EG338_RS03675	COG1595	DNA-templated transcription, initiation
EG338_RS03690	COG0481	GTPase activity
EG338_RS03730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EG338_RS03740	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EG338_RS03760	COG0791	NLP P60 protein
EG338_RS03765	COG0772	Belongs to the SEDS family
EG338_RS03770	COG0768	penicillin binding
EG338_RS03790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EG338_RS03795	COG0181	hydroxymethylbilane synthase activity
EG338_RS03805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EG338_RS03820	COG4095	Psort location CytoplasmicMembrane, score
EG338_RS03840	COG0387	Pfam Sodium calcium exchanger
EG338_RS03865	COG0758	DNA mediated transformation
EG338_RS03880	COG0606	chelatase, subunit chli
EG338_RS03965	COG0811	peptide transport
EG338_RS03980	COG0745	RESPONSE REGULATOR receiver
EG338_RS03985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EG338_RS03990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EG338_RS03995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EG338_RS04005	COG0423	glycine-tRNA ligase activity
EG338_RS04010	COG0569	domain protein
EG338_RS04015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EG338_RS04020	COG0167	dihydroorotate dehydrogenase activity
EG338_RS04025	COG2733	membrane
EG338_RS04030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS04055	COG0316	Belongs to the HesB IscA family
EG338_RS04060	COG0719	Fe-S assembly protein
EG338_RS04065	COG0396	ATPase activity
EG338_RS04070	COG0719	Fe-S assembly protein
EG338_RS04080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG338_RS04080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG338_RS04085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EG338_RS04095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EG338_RS04095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EG338_RS04110	COG0497	DNA recombination
EG338_RS04135	COG1309	transcriptional regulator
EG338_RS04140	COG0084	hydrolase, TatD family'
EG338_RS04145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EG338_RS04150	COG0594	ribonuclease P activity
EG338_RS04180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG338_RS04205	COG2176	DNA-directed DNA polymerase activity
EG338_RS04210	COG0433	COG0433 Predicted ATPase
EG338_RS04245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG338_RS04245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG338_RS04255	COG3118	belongs to the thioredoxin family
EG338_RS04275	COG0750	zinc metalloprotease
EG338_RS04335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EG338_RS04340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EG338_RS04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG338_RS04370	COG2608	mercury ion transmembrane transporter activity
EG338_RS04390	COG1830	Aldolase
EG338_RS04400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EG338_RS04425	COG2217	Heavy metal translocating P-type atpase
EG338_RS04430	COG2132	Multicopper oxidase
EG338_RS04445	COG2217	Heavy metal translocating P-type atpase
EG338_RS04465	COG2195	Cleaves the N-terminal amino acid of tripeptides
EG338_RS04480	COG2151	metal-sulfur cluster biosynthetic enzyme
EG338_RS04490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EG338_RS04500	COG4948	Mandelate Racemase Muconate Lactonizing
EG338_RS04505	COG1703	isobutyryl-CoA mutase activity
EG338_RS04535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EG338_RS04540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EG338_RS04545	COG0602	queuosine metabolic process
EG338_RS04550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EG338_RS04560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EG338_RS04565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EG338_RS04575	COG2181	nitrate reductase activity
EG338_RS04575	COG0247	lactate metabolic process
EG338_RS04580	COG0247	lactate metabolic process
EG338_RS04580	COG2181	nitrate reductase activity
EG338_RS04590	COG0438	transferase activity, transferring glycosyl groups
EG338_RS04610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EG338_RS04650	COG2217	Heavy metal translocating P-type atpase
EG338_RS04655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG338_RS04660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EG338_RS04680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG338_RS04685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG338_RS04690	COG1607	acyl-coa hydrolase
EG338_RS04700	COG3871	stress protein (general stress protein 26)
EG338_RS04715	COG4221	oxidoreductase activity
EG338_RS04720	COG1793	dna ligase
EG338_RS04720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EG338_RS04725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EG338_RS04725	COG1793	dna ligase
EG338_RS04730	COG1201	RNA secondary structure unwinding
EG338_RS04740	COG1528	Iron-storage protein
EG338_RS04745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EG338_RS04750	COG0443	Heat shock 70 kDa protein
EG338_RS04790	COG0484	heat shock protein binding
EG338_RS04815	COG0071	Belongs to the small heat shock protein (HSP20) family
EG338_RS04835	COG0517	IMP dehydrogenase activity
EG338_RS04860	COG4974	Belongs to the 'phage' integrase family
EG338_RS04920	COG2855	membrane
EG338_RS04925	COG0583	DNA-binding transcription factor activity
EG338_RS04945	COG4974	Belongs to the 'phage' integrase family
EG338_RS04950	COG0517	IMP dehydrogenase activity
EG338_RS04975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EG338_RS04985	COG0564	pseudouridine synthase activity
EG338_RS04990	COG2816	NAD+ diphosphatase activity
EG338_RS04995	COG4974	Belongs to the 'phage' integrase family
EG338_RS05005	COG1024	Enoyl-CoA hydratase
EG338_RS05035	COG0546	phosphoglycolate phosphatase activity
EG338_RS05040	COG0180	Tryptophanyl-tRNA synthetase
EG338_RS05045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EG338_RS05060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EG338_RS05065	COG3275	phosphorelay sensor kinase activity
EG338_RS05090	COG1216	Glycosyl transferase, family 2
EG338_RS05090	COG1442	glycosyl transferase family 8
EG338_RS05100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EG338_RS05120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EG338_RS05170	COG1132	(ABC) transporter
EG338_RS05175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EG338_RS05190	COG0569	domain protein
EG338_RS05190	COG2985	domain, Protein
EG338_RS05210	COG1472	Belongs to the glycosyl hydrolase 3 family
EG338_RS05220	COG0813	purine-nucleoside phosphorylase activity
EG338_RS05225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG338_RS05225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG338_RS05240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EG338_RS05260	COG0756	dUTP diphosphatase activity
EG338_RS05270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EG338_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
EG338_RS05290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EG338_RS05295	COG0326	Molecular chaperone. Has ATPase activity
EG338_RS05305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EG338_RS05310	COG1506	peptidase
EG338_RS05315	COG3177	Filamentation induced by cAMP protein fic
EG338_RS05330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EG338_RS05340	COG0018	arginyl-trna synthetase
EG338_RS05350	COG1629	transport
EG338_RS05355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EG338_RS05365	COG0706	membrane insertase activity
EG338_RS05370	COG0504	CTP synthase activity
EG338_RS05375	COG3227	Zinc metalloprotease (Elastase)
EG338_RS05380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EG338_RS05425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EG338_RS05465	COG0571	ribonuclease III activity
EG338_RS05475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EG338_RS05490	COG3396	Phenylacetate-CoA oxygenase
EG338_RS05505	COG0542	response to heat
EG338_RS05515	COG0488	(ABC) transporter
EG338_RS05525	COG2363	Small membrane protein
EG338_RS05535	COG0045	succinate-CoA ligase (ADP-forming) activity
EG338_RS05540	COG4115	mRNA cleavage
EG338_RS05545	COG2161	toxin-antitoxin pair type II binding
EG338_RS05550	COG0668	transmembrane transport
EG338_RS05560	COG2326	polyphosphate kinase activity
EG338_RS05570	COG0525	valine-tRNA ligase activity
EG338_RS05580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EG338_RS05590	COG2096	Adenosyltransferase
EG338_RS05605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EG338_RS05610	COG0010	Belongs to the arginase family
EG338_RS05635	COG1301	dicarboxylic acid transport
EG338_RS05640	COG1114	Component of the transport system for branched-chain amino acids
EG338_RS05650	COG0489	protein tyrosine kinase activity
EG338_RS05655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EG338_RS05670	COG3279	Response regulator of the LytR AlgR family
EG338_RS05685	COG0632	four-way junction helicase activity
EG338_RS05695	COG0302	gtp cyclohydrolase
EG338_RS05700	COG0215	cysteine-tRNA ligase activity
EG338_RS05705	COG1640	4-alpha-glucanotransferase
EG338_RS05730	COG1528	Iron-storage protein
EG338_RS05735	COG1074	ATP-dependent DNA helicase activity
EG338_RS05740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EG338_RS05745	COG4974	Belongs to the 'phage' integrase family
EG338_RS05775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EG338_RS05795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EG338_RS05800	COG0081	regulation of translation
EG338_RS05805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EG338_RS05810	COG0222	ribosome binding
EG338_RS05825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EG338_RS05850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG338_RS05850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG338_RS05855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EG338_RS05880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EG338_RS05890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG338_RS05895	COG3339	Conserved Protein
EG338_RS05900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EG338_RS05910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG338_RS05920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EG338_RS05935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EG338_RS05950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EG338_RS05955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EG338_RS05960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EG338_RS05965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EG338_RS05980	COG0194	GDP metabolic process
EG338_RS05985	COG1561	YicC-like family, N-terminal region
EG338_RS05995	COG0564	pseudouridine synthase activity
EG338_RS06015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EG338_RS06035	COG3206	protein involved in exopolysaccharide biosynthesis
EG338_RS06035	COG0489	protein tyrosine kinase activity
EG338_RS06045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EG338_RS06070	COG0438	transferase activity, transferring glycosyl groups
EG338_RS06075	COG0438	transferase activity, transferring glycosyl groups
EG338_RS06085	COG0463	Glycosyl transferase, family 2
EG338_RS06085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EG338_RS06170	COG3328	transposase activity
EG338_RS06180	COG2135	peptidase activity
EG338_RS06185	COG1525	nuclease
EG338_RS06190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG338_RS06195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EG338_RS06210	COG4771	TonB-dependent receptor
EG338_RS06240	COG1917	Cupin 2, conserved barrel domain protein
EG338_RS06240	COG2207	Transcriptional regulator
EG338_RS06265	COG0095	Lipoate-protein ligase
EG338_RS06270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EG338_RS06280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EG338_RS06300	COG2244	polysaccharide biosynthetic process
EG338_RS06305	COG0463	Glycosyl transferase, family 2
EG338_RS06315	COG0438	transferase activity, transferring glycosyl groups
EG338_RS06325	COG1086	Polysaccharide biosynthesis protein
EG338_RS06350	COG0297	glycogen (starch) synthase activity
EG338_RS06390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG338_RS06400	COG0708	Exodeoxyribonuclease III
EG338_RS06420	COG1078	dGTPase activity
EG338_RS06425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG338_RS06430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EG338_RS06430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EG338_RS06435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG338_RS06440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EG338_RS06445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG338_RS06460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EG338_RS06475	COG4152	abc transporter atp-binding protein
EG338_RS06500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EG338_RS06510	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EG338_RS06515	COG0460	homoserine dehydrogenase
EG338_RS06515	COG0527	aspartate kinase activity
EG338_RS06600	COG2204	response regulator
EG338_RS06620	COG1136	(ABC) transporter
EG338_RS06620	COG0577	efflux transmembrane transporter activity
EG338_RS06630	COG0577	efflux transmembrane transporter activity
EG338_RS06630	COG1136	(ABC) transporter
EG338_RS06640	COG1959	2 iron, 2 sulfur cluster binding
EG338_RS06660	COG1999	signal sequence binding
EG338_RS06665	COG4654	Cytochrome c, class I
EG338_RS06670	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EG338_RS06680	COG1193	negative regulation of DNA recombination
EG338_RS06685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EG338_RS06705	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EG338_RS06710	COG0596	Alpha beta hydrolase
EG338_RS06715	COG1086	Polysaccharide biosynthesis protein
EG338_RS06735	COG2095	MarC family integral membrane protein
EG338_RS06775	COG0714	Associated with various cellular activities
EG338_RS06785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG338_RS06795	COG0778	Nitroreductase
EG338_RS06805	COG0113	porphobilinogen synthase activity
EG338_RS06820	COG0336	Belongs to the RNA methyltransferase TrmD family
EG338_RS06830	COG1522	sequence-specific DNA binding
EG338_RS06835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EG338_RS06845	COG0488	(ABC) transporter
EG338_RS06850	COG0531	amino acid
EG338_RS06855	COG4774	siderophore transport
EG338_RS06860	COG0228	four-way junction DNA binding
EG338_RS06865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EG338_RS06870	COG0017	Asparaginyl-tRNA synthetase
EG338_RS06890	COG1137	ATPase activity
EG338_RS06895	COG1132	(ABC) transporter
EG338_RS06905	COG1418	mRNA catabolic process
EG338_RS06915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG338_RS06920	COG1136	(ABC) transporter
EG338_RS06920	COG0577	efflux transmembrane transporter activity
EG338_RS06925	COG1136	(ABC) transporter
EG338_RS06925	COG0577	efflux transmembrane transporter activity
EG338_RS06930	COG1136	(ABC) transporter
EG338_RS06965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EG338_RS06970	COG0783	Belongs to the Dps family
EG338_RS06980	COG1546	Belongs to the CinA family
EG338_RS06980	COG1058	Belongs to the CinA family
EG338_RS06995	COG3590	peptidase
EG338_RS07000	COG1253	flavin adenine dinucleotide binding
EG338_RS07005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EG338_RS07020	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EG338_RS07025	COG0427	acetyl-CoA hydrolase
EG338_RS07030	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EG338_RS07055	COG1530	ribonuclease E activity
EG338_RS07060	COG0776	regulation of translation
EG338_RS07075	COG0351	phosphomethylpyrimidine kinase
EG338_RS07075	COG0352	thiamine-phosphate diphosphorylase activity
EG338_RS07090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EG338_RS07120	COG1185	polyribonucleotide nucleotidyltransferase activity
EG338_RS07130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EG338_RS07140	COG2239	Acts as a magnesium transporter
EG338_RS07150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EG338_RS07155	COG0737	Belongs to the 5'-nucleotidase family
EG338_RS07160	COG0737	Belongs to the 5'-nucleotidase family
EG338_RS07185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EG338_RS07205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EG338_RS07210	COG0297	glycogen (starch) synthase activity
EG338_RS07220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EG338_RS07225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EG338_RS07250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EG338_RS07265	COG0471	metal ion transport
EG338_RS07360	COG0210	DNA helicase
EG338_RS07385	COG0252	asparaginase activity
EG338_RS07400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EG338_RS07405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EG338_RS07415	COG1522	sequence-specific DNA binding
EG338_RS07425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EG338_RS07430	COG3959	Transketolase, thiamine diphosphate binding domain
EG338_RS07435	COG4145	pantothenate transmembrane transporter activity
EG338_RS07460	COG0702	epimerase
EG338_RS07470	COG0477	Major facilitator Superfamily
EG338_RS07480	COG3549	Plasmid maintenance system killer
EG338_RS07495	COG0367	asparagine synthase
EG338_RS07500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EG338_RS07500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EG338_RS07505	COG2824	Alkylphosphonate utilization operon protein PhnA
EG338_RS07520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EG338_RS07535	COG1408	metallophosphoesterase
EG338_RS07550	COG2226	methyltransferase
EG338_RS07570	COG1418	mRNA catabolic process
EG338_RS07585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EG338_RS07590	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EG338_RS07600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG338_RS07605	COG1970	mechanosensitive ion channel activity
EG338_RS07615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EG338_RS07625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG338_RS07630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EG338_RS07635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EG338_RS07640	COG0077	Prephenate dehydratase
EG338_RS07645	COG3340	Belongs to the peptidase S51 family
EG338_RS07655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EG338_RS07660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EG338_RS07675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EG338_RS07695	COG4206	TonB-dependent receptor
EG338_RS07695	COG1629	transport
EG338_RS07700	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EG338_RS07710	COG1082	Xylose isomerase domain protein TIM barrel
EG338_RS07720	COG0366	Alpha amylase catalytic
EG338_RS07740	COG1741	Belongs to the pirin family
EG338_RS07750	COG2354	Protein conserved in bacteria
EG338_RS07755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EG338_RS07760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EG338_RS07770	COG0151	Belongs to the GarS family
EG338_RS07775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EG338_RS07775	COG0519	Catalyzes the synthesis of GMP from XMP
EG338_RS07785	COG0513	Belongs to the DEAD box helicase family
EG338_RS07815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EG338_RS07830	COG1289	transmembrane transporter activity
EG338_RS07850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EG338_RS07865	COG1131	(ABC) transporter
EG338_RS07870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EG338_RS07875	COG0671	phosphoesterase, PA-phosphatase related
EG338_RS07915	COG0366	Alpha amylase catalytic
EG338_RS07920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG338_RS07930	COG0513	Belongs to the DEAD box helicase family
EG338_RS07940	COG0306	phosphate transporter
EG338_RS07955	COG0084	hydrolase, TatD family'
EG338_RS07960	COG0513	Belongs to the DEAD box helicase family
EG338_RS07970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EG338_RS07975	COG0563	adenylate kinase activity
EG338_RS07980	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EG338_RS07985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EG338_RS07995	COG1192	Involved in chromosome partitioning
EG338_RS08000	COG1475	DNA binding
EG338_RS08010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EG338_RS08015	COG0681	Belongs to the peptidase S26 family
EG338_RS08025	COG1404	Belongs to the peptidase S8 family
EG338_RS08035	COG2885	chlorophyll binding
EG338_RS08040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EG338_RS08045	COG0277	FAD linked oxidase domain protein
EG338_RS08050	COG0300	oxidoreductase activity
EG338_RS08060	COG1104	cysteine desulfurase activity
EG338_RS08065	COG3118	belongs to the thioredoxin family
EG338_RS08205	COG0484	heat shock protein binding
EG338_RS08265	COG0739	heme binding
EG338_RS08275	COG2003	Belongs to the UPF0758 family
EG338_RS08295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG338_RS08315	COG3657	addiction module killer protein
EG338_RS08325	COG0517	IMP dehydrogenase activity
EG338_RS08330	COG4974	Belongs to the 'phage' integrase family
EG338_RS08340	COG0517	IMP dehydrogenase activity
EG338_RS08345	COG4974	Belongs to the 'phage' integrase family
EG338_RS08370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EG338_RS08385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08415	COG1012	belongs to the aldehyde dehydrogenase family
EG338_RS08425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EG338_RS08430	COG0183	Belongs to the thiolase family
EG338_RS08435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EG338_RS08450	COG1484	DNA-dependent DNA replication
EG338_RS08455	COG4584	PFAM Integrase catalytic
EG338_RS08460	COG2205	protein histidine kinase activity
EG338_RS08460	COG0745	RESPONSE REGULATOR receiver
EG338_RS08460	COG3292	Two component regulator propeller
EG338_RS08505	COG3059	membrane
EG338_RS08555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EG338_RS08560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08585	COG1573	uracil-dna glycosylase
EG338_RS08615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG338_RS08660	COG4974	Belongs to the 'phage' integrase family
EG338_RS08670	COG4974	Belongs to the 'phage' integrase family
EG338_RS08675	COG0517	IMP dehydrogenase activity
EG338_RS08725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EG338_RS08740	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG338_RS08745	COG2967	ApaG domain
EG338_RS08755	COG0463	Glycosyl transferase, family 2
EG338_RS08770	COG1012	belongs to the aldehyde dehydrogenase family
EG338_RS08775	COG0300	oxidoreductase activity
EG338_RS08780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EG338_RS08785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EG338_RS08805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EG338_RS08815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EG338_RS08825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EG338_RS08840	COG0156	8-amino-7-oxononanoate synthase activity
EG338_RS08845	COG0730	response to heat
EG338_RS08855	COG0175	sulfate reduction
EG338_RS08860	COG0175	sulfate reduction
EG338_RS08865	COG1959	2 iron, 2 sulfur cluster binding
EG338_RS08885	COG1981	membrane
EG338_RS08900	COG1702	phosphate starvation-inducible protein PhoH
EG338_RS08925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EG338_RS08940	COG0356	it plays a direct role in the translocation of protons across the membrane
EG338_RS08950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EG338_RS08955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EG338_RS08960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EG338_RS08965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EG338_RS08970	COG1253	flavin adenine dinucleotide binding
EG338_RS08975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EG338_RS08985	COG2890	protein-(glutamine-N5) methyltransferase activity
EG338_RS08990	COG0791	NLP P60 protein
EG338_RS08995	COG2171	N-acyltransferase activity
EG338_RS09010	COG2234	aminopeptidase activity
EG338_RS09015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EG338_RS09020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EG338_RS09025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EG338_RS09030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EG338_RS09055	COG1960	acyl-CoA dehydrogenase activity
EG338_RS09080	COG0539	negative regulation of cytoplasmic translation
EG338_RS09080	COG2183	response to ionizing radiation
EG338_RS09090	COG0335	large ribosomal subunit rRNA binding
EG338_RS09095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EG338_RS09110	COG0137	argininosuccinate synthase activity
EG338_RS09115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EG338_RS09120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EG338_RS09125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EG338_RS09130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EG338_RS09135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EG338_RS09145	COG1522	sequence-specific DNA binding
EG338_RS09160	COG1011	Hydrolase
EG338_RS09185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EG338_RS09200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG338_RS09205	COG0730	response to heat
EG338_RS09215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG338_RS09215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG338_RS09220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG338_RS09250	COG0659	secondary active sulfate transmembrane transporter activity
EG338_RS09260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EG338_RS09270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EG338_RS09270	COG1605	Chorismate mutase
EG338_RS09280	COG1162	GTPase activity
EG338_RS09285	COG0105	UTP biosynthetic process
EG338_RS09300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EG338_RS09310	COG1363	Peptidase, m42
EG338_RS09330	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EG338_RS09330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EG338_RS09335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EG338_RS09345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EG338_RS09350	COG0739	heme binding
EG338_RS09360	COG0579	oxidoreductase
EG338_RS09370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG338_RS09390	COG1525	nuclease
EG338_RS09395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EG338_RS09400	COG0586	Pfam SNARE associated Golgi protein
EG338_RS09405	COG0484	heat shock protein binding
EG338_RS09410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EG338_RS09415	COG1914	H( )-stimulated, divalent metal cation uptake system
EG338_RS09425	COG0442	prolyl-tRNA aminoacylation
EG338_RS09450	COG0116	Belongs to the methyltransferase superfamily
EG338_RS09450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EG338_RS09455	COG0463	Glycosyl transferase, family 2
EG338_RS09455	COG1216	Glycosyl transferase, family 2
EG338_RS09460	COG2264	protein methyltransferase activity
EG338_RS09495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EG338_RS09510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EG338_RS09565	COG0183	Belongs to the thiolase family
EG338_RS09595	COG0598	Magnesium transport protein CorA
EG338_RS09600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG338_RS09605	COG1446	asparaginase
EG338_RS09610	COG4242	Belongs to the peptidase S51 family
EG338_RS09615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EG338_RS09620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EG338_RS09625	COG0083	homoserine kinase activity
EG338_RS09630	COG0460	homoserine dehydrogenase
EG338_RS09630	COG0527	aspartate kinase activity
EG338_RS09640	COG1217	gtp-binding protein TYPA
EG338_RS09665	COG0012	GTP binding
EG338_RS09690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG338_RS09710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EG338_RS09720	COG0528	UMP kinase activity
EG338_RS09725	COG0233	cytoplasmic translational termination
EG338_RS09735	COG2315	Protein conserved in bacteria
EG338_RS09745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EG338_RS09760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EG338_RS09765	COG0156	8-amino-7-oxononanoate synthase activity
EG338_RS09785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EG338_RS09795	COG3153	acetyltransferase
EG338_RS09795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EG338_RS09830	COG1462	curli production assembly transport component CsgG
EG338_RS09880	COG2204	response regulator
EG338_RS09885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EG338_RS09900	COG4585	Histidine kinase
EG338_RS09905	COG2197	response regulator
EG338_RS09915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EG338_RS09925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EG338_RS09950	COG0540	Belongs to the ATCase OTCase family
EG338_RS09965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EG338_RS09985	COG4585	Histidine kinase
EG338_RS09990	COG2197	response regulator
EG338_RS10010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EG338_RS10010	COG2169	Transcriptional regulator
EG338_RS10020	COG1012	belongs to the aldehyde dehydrogenase family
EG338_RS10035	COG0022	dehydrogenase e1 component
EG338_RS10040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EG338_RS10065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG338_RS10070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EG338_RS10075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EG338_RS10090	COG0753	catalase activity
EG338_RS10125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EG338_RS10165	COG3550	peptidyl-serine autophosphorylation
EG338_RS10195	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG338_RS10240	COG0805	protein transport
EG338_RS10245	COG0517	IMP dehydrogenase activity
EG338_RS10245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EG338_RS10250	COG0514	ATP-dependent DNA helicase (RecQ)
EG338_RS10260	COG0438	transferase activity, transferring glycosyl groups
EG338_RS10295	COG0798	PFAM Bile acid sodium symporter
EG338_RS10310	COG0640	Transcriptional regulator
EG338_RS10315	COG0436	Aminotransferase
EG338_RS10345	COG0592	DNA-directed DNA polymerase activity
EG338_RS10370	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG338_RS10385	COG0673	inositol 2-dehydrogenase activity
EG338_RS10390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EG338_RS10395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EG338_RS10395	COG1333	cytochrome c biogenesis protein
EG338_RS10400	COG1234	tRNA 3'-trailer cleavage
EG338_RS10415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EG338_RS10420	COG2177	Part of the ABC transporter FtsEX involved in
EG338_RS10430	COG1968	undecaprenyl-diphosphatase activity
EG338_RS10435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EG338_RS10440	COG1187	pseudouridine synthase activity
EG338_RS10450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EG338_RS10450	COG4651	solute:proton antiporter activity
EG338_RS10470	COG1960	acyl-CoA dehydrogenase activity
EG338_RS10475	COG0183	Belongs to the thiolase family
EG338_RS10480	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG338_RS10480	COG1024	Enoyl-CoA hydratase
EG338_RS10500	COG3118	belongs to the thioredoxin family
EG338_RS10505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EG338_RS10505	COG1017	nitric oxide dioxygenase activity
EG338_RS10510	COG2949	membrane
EG338_RS10515	COG0572	uridine kinase
EG338_RS10525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG338_RS10525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG338_RS10545	COG0300	oxidoreductase activity
EG338_RS10555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EG338_RS10565	COG4585	Histidine kinase
EG338_RS10575	COG2211	Major facilitator Superfamily
EG338_RS10580	COG0183	Belongs to the thiolase family
EG338_RS10585	COG2270	Major facilitator Superfamily
EG338_RS10600	COG1187	pseudouridine synthase activity
EG338_RS10610	COG2207	Transcriptional regulator
EG338_RS10610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EG338_RS10630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EG338_RS10680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EG338_RS10680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EG338_RS10690	COG2337	Toxic component of a toxin-antitoxin (TA) module
EG338_RS10715	COG0531	amino acid
EG338_RS10740	COG1764	response to oxidative stress
EG338_RS10745	COG1846	Transcriptional regulator
EG338_RS10750	COG0778	Nitroreductase
EG338_RS10755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EG338_RS10775	COG1477	protein flavinylation
EG338_RS10780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG338_RS10785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EG338_RS10795	COG0436	Aminotransferase
EG338_RS10800	COG0357	Ribosomal RNA small subunit methyltransferase G
EG338_RS10815	COG0300	oxidoreductase activity
EG338_RS10820	COG1047	Peptidyl-prolyl cis-trans
EG338_RS10830	COG2217	Heavy metal translocating P-type atpase
EG338_RS10850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EG338_RS10855	COG0004	ammonium transporteR
EG338_RS10860	COG0022	dehydrogenase e1 component
EG338_RS10865	COG1960	acyl-CoA dehydrogenase activity
EG338_RS10885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EG338_RS10920	COG1649	PFAM Uncharacterised BCR, COG1649
EG338_RS10935	COG0009	L-threonylcarbamoyladenylate synthase
EG338_RS10940	COG3022	response to hydroperoxide
EG338_RS10945	COG1607	acyl-coa hydrolase
EG338_RS10955	COG2217	Heavy metal translocating P-type atpase
EG338_RS10970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EG338_RS10985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EG338_RS11005	COG0823	Involved in the tonB-independent uptake of proteins
EG338_RS11005	COG1506	peptidase
EG338_RS11015	COG1950	PFAM Membrane protein of
EG338_RS11025	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EG338_RS11030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EG338_RS11045	COG2003	Belongs to the UPF0758 family
EG338_RS11050	COG1136	(ABC) transporter
EG338_RS11080	COG0724	RNA recognition motif
EG338_RS11090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EG338_RS11110	COG2318	DinB family
EG338_RS11115	COG1335	isochorismatase
EG338_RS11125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EG338_RS11135	COG1607	acyl-coa hydrolase
EG338_RS11145	COG1674	ftsk spoiiie
EG338_RS11155	COG0795	lipopolysaccharide-transporting ATPase activity
EG338_RS11160	COG0386	Belongs to the glutathione peroxidase family
EG338_RS11170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EG338_RS11180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EG338_RS11195	COG0463	Glycosyl transferase, family 2
EG338_RS11215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EG338_RS11220	COG1715	Restriction endonuclease
EG338_RS11225	COG1575	Belongs to the MenA family. Type 1 subfamily
EG338_RS11240	COG0531	amino acid
EG338_RS11265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG338_RS11270	COG0823	Involved in the tonB-independent uptake of proteins
EG338_RS11270	COG1506	peptidase
EG338_RS11280	COG3104	oligopeptide transport
EG338_RS11295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EG338_RS11330	COG0149	triose-phosphate isomerase activity
EG338_RS11340	COG0358	DNA primase activity
EG338_RS11345	COG0802	atpase or kinase
EG338_RS11360	COG0287	Prephenate dehydrogenase
EG338_RS11365	COG1760	l-serine dehydratase
EG338_RS11375	COG0837	glucose binding
EG338_RS11390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EG338_RS11405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EG338_RS11405	COG0321	lipoyl(octanoyl) transferase activity
EG338_RS11420	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG338_RS11435	COG0321	lipoyl(octanoyl) transferase activity
EG338_RS11445	COG0159	tryptophan synthase activity
EG338_RS11450	COG0133	tryptophan synthase activity
EG338_RS11455	COG0135	phosphoribosylanthranilate isomerase activity
EG338_RS11460	COG0134	indole-3-glycerol-phosphate synthase activity
EG338_RS11465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EG338_RS11470	COG0512	Glutamine amidotransferase of anthranilate synthase
EG338_RS11470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EG338_RS11510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EG338_RS11520	COG1271	oxidase subunit
EG338_RS11525	COG0187	DNA topoisomerase II activity
EG338_RS11540	COG0405	Gamma-glutamyltransferase
EG338_RS11545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EG338_RS11555	COG0360	Binds together with S18 to 16S ribosomal RNA
EG338_RS11560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EG338_RS11565	COG0359	binds to the 23S rRNA
EG338_RS11575	COG0069	glutamate synthase activity
EG338_RS11590	COG1090	epimerase
EG338_RS11595	COG1393	Belongs to the ArsC family
EG338_RS11600	COG1428	Deoxynucleoside kinase
EG338_RS11635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EG338_RS11640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EG338_RS11645	COG1295	ribonuclease BN
EG338_RS11650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EG338_RS11670	COG0210	DNA helicase
EG338_RS11685	COG5002	protein histidine kinase activity
EG338_RS11705	COG0110	maltose O-acetyltransferase activity
EG338_RS11710	COG1216	Glycosyl transferase, family 2
EG338_RS11715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EG338_RS11725	COG2195	Cleaves the N-terminal amino acid of tripeptides
EG338_RS11735	COG0633	Ferredoxin
EG338_RS11740	COG0492	ferredoxin-NADP+ reductase activity
EG338_RS11750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EG338_RS11755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EG338_RS11800	COG1960	acyl-CoA dehydrogenase activity
EG338_RS11805	COG1022	Amp-dependent synthetase and ligase
EG338_RS11840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EG338_RS11845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EG338_RS11850	COG0440	acetolactate synthase activity
EG338_RS11855	COG0028	Belongs to the TPP enzyme family
EG338_RS11860	COG0129	dihydroxy-acid dehydratase activity
EG338_RS11870	COG0587	DNA-directed DNA polymerase activity
EG338_RS11875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG338_RS11970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EG338_RS11985	COG0732	type I restriction modification DNA specificity domain
EG338_RS11990	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EG338_RS12015	COG0358	DNA primase activity
EG338_RS12040	COG0346	lactoylglutathione lyase activity
EG338_RS12045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EG338_RS12055	COG2356	endonuclease I
EG338_RS12060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EG338_RS12075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG338_RS12075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG338_RS12080	COG1739	Uncharacterized protein family UPF0029
EG338_RS12100	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG338_RS12105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG338_RS12110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG338_RS12115	COG0649	NAD binding
EG338_RS12120	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EG338_RS12135	COG1034	ATP synthesis coupled electron transport
EG338_RS12140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EG338_RS12145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG338_RS12155	COG0713	ATP synthesis coupled electron transport
EG338_RS12160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EG338_RS12165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG338_RS12170	COG1007	ATP synthesis coupled electron transport
EG338_RS12175	COG1012	belongs to the aldehyde dehydrogenase family
EG338_RS12185	COG1289	transmembrane transporter activity
EG338_RS12190	COG3956	TIGRFAM MazG family protein
EG338_RS12200	COG0242	peptide deformylase activity
EG338_RS12205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EG338_RS12230	COG0284	orotidine-5'-phosphate decarboxylase activity
EG338_RS12230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EG338_RS12270	COG3876	Protein conserved in bacteria
EG338_RS12275	COG4591	ABC-type transport system involved in lipoprotein release permease component
EG338_RS12310	COG0339	signal peptide processing
EG338_RS12320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EG338_RS12330	COG0259	pyridoxamine-phosphate oxidase activity
EG338_RS12335	COG1678	Uncharacterized ACR, COG1678
EG338_RS12350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EG338_RS12360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EG338_RS12360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EG338_RS12365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EG338_RS12400	COG4974	Belongs to the 'phage' integrase family
EG338_RS12405	COG0517	IMP dehydrogenase activity
EG338_RS12450	COG4974	Belongs to the 'phage' integrase family
EG338_RS12470	COG0531	amino acid
EG338_RS12485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EG338_RS12490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EG338_RS12505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EG338_RS12545	COG0297	glycogen (starch) synthase activity
EG338_RS12550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EG338_RS12565	COG4717	serine-type aminopeptidase activity
EG338_RS12590	COG0612	Peptidase, M16
EG338_RS12600	COG3023	N-Acetylmuramoyl-L-alanine amidase
EG338_RS12630	COG3158	transport of potassium into the cell
EG338_RS12635	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG338_RS12635	COG0022	dehydrogenase e1 component
EG338_RS12645	COG1368	sulfuric ester hydrolase activity
EG338_RS12650	COG1183	phosphatidylcholine synthase activity
EG338_RS12660	COG0179	Fumarylacetoacetate (FAA) hydrolase
EG338_RS12690	COG0544	peptidyl-prolyl cis-trans isomerase activity
EG338_RS12710	COG0205	6-phosphofructokinase activity
EG338_RS12745	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG338_RS12750	COG0720	synthase
EG338_RS12755	COG2224	Isocitrate lyase
EG338_RS12760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EG338_RS12770	COG1040	competence protein
EG338_RS12775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EG338_RS12780	COG1160	GTP binding
EG338_RS12785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EG338_RS12805	COG0450	alkyl hydroperoxide reductase
EG338_RS12810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG338_RS12855	COG2226	methyltransferase
EG338_RS12860	COG0124	histidyl-tRNA synthetase
EG338_RS12870	COG0629	single-stranded DNA binding
EG338_RS12875	COG0673	inositol 2-dehydrogenase activity
EG338_RS12885	COG0784	Response regulator, receiver
EG338_RS12885	COG5002	protein histidine kinase activity
EG338_RS12895	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EG338_RS12910	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EG338_RS12930	COG0484	heat shock protein binding
EG338_RS12935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EG338_RS12960	COG0626	cystathionine gamma-synthase activity
EG338_RS12975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EG338_RS12980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EG338_RS12985	COG0346	lactoylglutathione lyase activity
EG338_RS12990	COG1169	isochorismate synthase
EG338_RS13020	COG1301	dicarboxylic acid transport