locus-tag	class	description
EG343_RS00005	COG1629	transport
EG343_RS00020	COG1472	Belongs to the glycosyl hydrolase 3 family
EG343_RS00035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EG343_RS00045	COG0519	Catalyzes the synthesis of GMP from XMP
EG343_RS00060	COG0813	purine-nucleoside phosphorylase activity
EG343_RS00070	COG1858	cytochrome C peroxidase
EG343_RS00095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EG343_RS00115	COG2226	methyltransferase
EG343_RS00120	COG2076	Multidrug Resistance protein
EG343_RS00130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EG343_RS00140	COG1506	peptidase
EG343_RS00155	COG1247	-acetyltransferase
EG343_RS00160	COG0534	Mate efflux family protein
EG343_RS00165	COG2204	response regulator
EG343_RS00170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EG343_RS00185	COG2217	Heavy metal translocating P-type atpase
EG343_RS00195	COG1607	acyl-coa hydrolase
EG343_RS00205	COG0724	RNA recognition motif
EG343_RS00240	COG1136	(ABC) transporter
EG343_RS00250	COG2003	Belongs to the UPF0758 family
EG343_RS00270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EG343_RS00275	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EG343_RS00280	COG0436	Aminotransferase
EG343_RS00285	COG2234	aminopeptidase activity
EG343_RS00305	COG0183	Belongs to the thiolase family
EG343_RS00320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EG343_RS00325	COG0300	oxidoreductase activity
EG343_RS00365	COG0477	Major facilitator Superfamily
EG343_RS00390	COG2249	NAD(P)H dehydrogenase (quinone) activity
EG343_RS00395	COG0657	acetylesterase activity
EG343_RS00415	COG0415	Belongs to the DNA photolyase family
EG343_RS00420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EG343_RS00520	COG3422	double-strand break repair
EG343_RS00525	COG1960	acyl-CoA dehydrogenase activity
EG343_RS00535	COG0183	Belongs to the thiolase family
EG343_RS00545	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG343_RS00545	COG1024	Enoyl-CoA hydratase
EG343_RS00555	COG1120	ATPase activity
EG343_RS00565	COG3118	belongs to the thioredoxin family
EG343_RS00570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EG343_RS00570	COG1017	nitric oxide dioxygenase activity
EG343_RS00575	COG2949	membrane
EG343_RS00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG343_RS00615	COG0528	UMP kinase activity
EG343_RS00625	COG0233	cytoplasmic translational termination
EG343_RS00630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG343_RS00660	COG1674	ftsk spoiiie
EG343_RS00675	COG1335	isochorismatase
EG343_RS00690	COG1333	cytochrome c biogenesis protein
EG343_RS00690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EG343_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS00760	COG3501	Rhs element vgr protein
EG343_RS00795	COG1215	transferase activity, transferring glycosyl groups
EG343_RS00820	COG3292	Two component regulator propeller
EG343_RS00820	COG2205	protein histidine kinase activity
EG343_RS00820	COG0745	RESPONSE REGULATOR receiver
EG343_RS00840	COG0791	NLP P60 protein
EG343_RS00850	COG2814	Major facilitator Superfamily
EG343_RS00865	COG2171	N-acyltransferase activity
EG343_RS00875	COG0463	Glycosyl transferase, family 2
EG343_RS00885	COG0438	transferase activity, transferring glycosyl groups
EG343_RS00890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EG343_RS00895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EG343_RS00900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EG343_RS00905	COG0131	Imidazoleglycerol-phosphate dehydratase
EG343_RS00915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EG343_RS00920	COG0107	imidazoleglycerol-phosphate synthase activity
EG343_RS00925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EG343_RS00925	COG0140	phosphoribosyl-ATP diphosphatase activity
EG343_RS00970	COG2234	aminopeptidase activity
EG343_RS00975	COG2234	aminopeptidase activity
EG343_RS00980	COG2234	aminopeptidase activity
EG343_RS00985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EG343_RS00990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EG343_RS01055	COG2197	response regulator
EG343_RS01075	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EG343_RS01080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EG343_RS01100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EG343_RS01105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EG343_RS01110	COG0066	3-isopropylmalate dehydratase activity
EG343_RS01165	COG1960	acyl-CoA dehydrogenase activity
EG343_RS01190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EG343_RS01225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EG343_RS01230	COG1187	pseudouridine synthase activity
EG343_RS01245	COG1335	isochorismatase
EG343_RS01250	COG0513	Belongs to the DEAD box helicase family
EG343_RS01255	COG2318	DinB family
EG343_RS01265	COG3118	belongs to the thioredoxin family
EG343_RS01275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EG343_RS01280	COG0697	spore germination
EG343_RS01300	COG1546	Belongs to the CinA family
EG343_RS01300	COG1058	Belongs to the CinA family
EG343_RS01325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EG343_RS01335	COG3871	stress protein (general stress protein 26)
EG343_RS01345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EG343_RS01360	COG0588	phosphoglycerate mutase activity
EG343_RS01370	COG1793	dna ligase
EG343_RS01375	COG1793	dna ligase
EG343_RS01375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EG343_RS01400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG343_RS01420	COG2814	Major facilitator Superfamily
EG343_RS01425	COG1733	regulation of RNA biosynthetic process
EG343_RS01440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EG343_RS01445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EG343_RS01460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG343_RS01470	COG4774	siderophore transport
EG343_RS01480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EG343_RS01490	COG0156	8-amino-7-oxononanoate synthase activity
EG343_RS01495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EG343_RS01500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EG343_RS01505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EG343_RS01510	COG1733	regulation of RNA biosynthetic process
EG343_RS01515	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EG343_RS01520	COG2807	transmembrane transport
EG343_RS01530	COG0534	Mate efflux family protein
EG343_RS01560	COG0667	Aldo Keto reductase
EG343_RS01570	COG0300	oxidoreductase activity
EG343_RS01575	COG1252	NADH dehydrogenase
EG343_RS01585	COG0745	RESPONSE REGULATOR receiver
EG343_RS01590	COG5002	protein histidine kinase activity
EG343_RS01610	COG0671	phosphoesterase, PA-phosphatase related
EG343_RS01620	COG4221	oxidoreductase activity
EG343_RS01655	COG2972	Histidine kinase
EG343_RS01660	COG3279	Response regulator of the LytR AlgR family
EG343_RS01665	COG2076	Multidrug Resistance protein
EG343_RS01675	COG2094	Belongs to the DNA glycosylase MPG family
EG343_RS01685	COG0006	proline dipeptidase activity
EG343_RS01695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EG343_RS01710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EG343_RS01780	COG1959	2 iron, 2 sulfur cluster binding
EG343_RS01785	COG0175	sulfate reduction
EG343_RS01790	COG0175	sulfate reduction
EG343_RS01800	COG1045	serine acetyltransferase
EG343_RS01810	COG1648	precorrin-2 dehydrogenase activity
EG343_RS01810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EG343_RS01815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EG343_RS01850	COG0596	Alpha beta hydrolase
EG343_RS01870	COG4977	sequence-specific DNA binding
EG343_RS01870	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS01885	COG0523	cobalamin synthesis protein
EG343_RS01890	COG1785	Belongs to the alkaline phosphatase family
EG343_RS01895	COG3620	sequence-specific DNA binding
EG343_RS01905	COG1522	sequence-specific DNA binding
EG343_RS01910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EG343_RS01930	COG1595	DNA-templated transcription, initiation
EG343_RS01940	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EG343_RS01975	COG2176	DNA-directed DNA polymerase activity
EG343_RS02035	COG0640	Transcriptional regulator
EG343_RS02045	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
EG343_RS02110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EG343_RS02135	COG2132	Multicopper oxidase
EG343_RS02155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EG343_RS02180	COG0156	8-amino-7-oxononanoate synthase activity
EG343_RS02205	COG3275	phosphorelay sensor kinase activity
EG343_RS02210	COG3279	Response regulator of the LytR AlgR family
EG343_RS02240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EG343_RS02250	COG0196	riboflavin kinase activity
EG343_RS02265	COG0702	epimerase
EG343_RS02285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EG343_RS02305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EG343_RS02360	COG0463	Glycosyl transferase, family 2
EG343_RS02375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EG343_RS02385	COG1575	Belongs to the MenA family. Type 1 subfamily
EG343_RS02400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EG343_RS02425	COG2323	membrane
EG343_RS02480	COG0531	amino acid
EG343_RS02515	COG2270	Major facilitator Superfamily
EG343_RS02520	COG0183	Belongs to the thiolase family
EG343_RS02535	COG2211	Major facilitator Superfamily
EG343_RS02545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EG343_RS02555	COG0300	oxidoreductase activity
EG343_RS02590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG343_RS02590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG343_RS02600	COG0572	uridine kinase
EG343_RS02610	COG1253	flavin adenine dinucleotide binding
EG343_RS02615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EG343_RS02620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EG343_RS02625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EG343_RS02630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EG343_RS02635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EG343_RS02640	COG0356	it plays a direct role in the translocation of protons across the membrane
EG343_RS02645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EG343_RS02675	COG1702	phosphate starvation-inducible protein PhoH
EG343_RS02685	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG343_RS02705	COG0360	Binds together with S18 to 16S ribosomal RNA
EG343_RS02710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EG343_RS02715	COG0359	binds to the 23S rRNA
EG343_RS02740	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS02765	COG2967	ApaG domain
EG343_RS02770	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG343_RS02785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EG343_RS02790	COG0297	glycogen (starch) synthase activity
EG343_RS02795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EG343_RS02805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EG343_RS02825	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EG343_RS02845	COG4242	Belongs to the peptidase S51 family
EG343_RS02850	COG1446	asparaginase
EG343_RS02860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EG343_RS02890	COG0124	histidyl-tRNA synthetase
EG343_RS02900	COG0629	single-stranded DNA binding
EG343_RS02960	COG1090	epimerase
EG343_RS02965	COG0494	nUDIX hydrolase
EG343_RS03030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS03045	COG2996	Protein conserved in bacteria
EG343_RS03065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EG343_RS03090	COG0438	transferase activity, transferring glycosyl groups
EG343_RS03095	COG0514	ATP-dependent DNA helicase (RecQ)
EG343_RS03100	COG0517	IMP dehydrogenase activity
EG343_RS03100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EG343_RS03115	COG0805	protein transport
EG343_RS03135	COG3852	Histidine kinase
EG343_RS03150	COG3340	Belongs to the peptidase S51 family
EG343_RS03165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EG343_RS03215	COG0456	acetyltransferase
EG343_RS03260	COG0009	L-threonylcarbamoyladenylate synthase
EG343_RS03270	COG3022	response to hydroperoxide
EG343_RS03275	COG2890	protein-(glutamine-N5) methyltransferase activity
EG343_RS03300	COG0300	oxidoreductase activity
EG343_RS03335	COG0436	Aminotransferase
EG343_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS03380	COG0012	GTP binding
EG343_RS03385	COG1528	Iron-storage protein
EG343_RS03390	COG1649	PFAM Uncharacterised BCR, COG1649
EG343_RS03395	COG1217	gtp-binding protein TYPA
EG343_RS03420	COG0693	protein deglycase activity
EG343_RS03430	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EG343_RS03445	COG4122	O-methyltransferase activity
EG343_RS03450	COG2183	response to ionizing radiation
EG343_RS03510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EG343_RS03525	COG2814	Major facilitator Superfamily
EG343_RS03530	COG3189	MarR family transcriptional regulator
EG343_RS03535	COG2706	6-phosphogluconolactonase activity
EG343_RS03565	COG2249	NAD(P)H dehydrogenase (quinone) activity
EG343_RS03585	COG2204	response regulator
EG343_RS03595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EG343_RS03600	COG3437	response regulator, receiver
EG343_RS03605	COG0784	Response regulator, receiver
EG343_RS03605	COG2205	protein histidine kinase activity
EG343_RS03610	COG5002	protein histidine kinase activity
EG343_RS03630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EG343_RS03645	COG0671	phosphoesterase, PA-phosphatase related
EG343_RS03660	COG0671	phosphoesterase, PA-phosphatase related
EG343_RS03665	COG1368	sulfuric ester hydrolase activity
EG343_RS03675	COG5002	protein histidine kinase activity
EG343_RS03680	COG0745	RESPONSE REGULATOR receiver
EG343_RS03695	COG3177	Filamentation induced by cAMP protein fic
EG343_RS03700	COG1431	PFAM Stem cell self-renewal protein Piwi
EG343_RS03705	COG5002	protein histidine kinase activity
EG343_RS03720	COG2003	Belongs to the UPF0758 family
EG343_RS03795	COG3781	membrane
EG343_RS03820	COG5002	protein histidine kinase activity
EG343_RS03905	COG4771	TonB-dependent receptor
EG343_RS03915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EG343_RS04000	COG1570	exodeoxyribonuclease VII activity
EG343_RS04020	COG1396	sequence-specific DNA binding
EG343_RS04025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG343_RS04030	COG0587	DNA-directed DNA polymerase activity
EG343_RS04045	COG1858	cytochrome C peroxidase
EG343_RS04065	COG1368	sulfuric ester hydrolase activity
EG343_RS04100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG343_RS04140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG343_RS04140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS04145	COG0730	response to heat
EG343_RS04150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG343_RS04185	COG0531	amino acid
EG343_RS04225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EG343_RS04250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG343_RS04255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EG343_RS04265	COG1794	racemase activity, acting on amino acids and derivatives
EG343_RS04275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EG343_RS04275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EG343_RS04280	COG0484	heat shock protein binding
EG343_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS04350	COG2267	carboxylic ester hydrolase activity
EG343_RS04385	COG2207	Transcriptional regulator
EG343_RS04410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EG343_RS04430	COG0667	Aldo Keto reductase
EG343_RS04470	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS04475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EG343_RS04505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EG343_RS04510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EG343_RS04520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EG343_RS04525	COG2852	Protein conserved in bacteria
EG343_RS04550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EG343_RS04580	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG343_RS04605	COG3059	membrane
EG343_RS04610	COG2207	Transcriptional regulator
EG343_RS04610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EG343_RS04615	COG0592	DNA-directed DNA polymerase activity
EG343_RS04650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EG343_RS04750	COG0702	epimerase
EG343_RS04755	COG1629	transport
EG343_RS04770	COG1393	Belongs to the ArsC family
EG343_RS04775	COG1428	Deoxynucleoside kinase
EG343_RS04805	COG0025	NhaP-type Na H and K H
EG343_RS04810	COG3781	membrane
EG343_RS04850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS04860	COG4574	serine-type endopeptidase inhibitor activity
EG343_RS04875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EG343_RS04895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EG343_RS04940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EG343_RS04955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EG343_RS04970	COG2169	Transcriptional regulator
EG343_RS04985	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS04985	COG4977	sequence-specific DNA binding
EG343_RS04995	COG4585	Histidine kinase
EG343_RS05010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EG343_RS05015	COG0698	ribose 5-phosphate isomerase
EG343_RS05020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EG343_RS05030	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EG343_RS05050	COG0583	DNA-binding transcription factor activity
EG343_RS05055	COG2153	protein acetylation
EG343_RS05110	COG2885	chlorophyll binding
EG343_RS05120	COG1073	alpha beta
EG343_RS05125	COG0702	epimerase
EG343_RS05155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS05165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EG343_RS05170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EG343_RS05175	COG0363	glucosamine-6-phosphate deaminase activity
EG343_RS05205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS05255	COG3279	Response regulator of the LytR AlgR family
EG343_RS05290	COG3275	phosphorelay sensor kinase activity
EG343_RS05405	COG1566	PFAM secretion protein HlyD family protein
EG343_RS05470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EG343_RS05475	COG2124	cytochrome p450
EG343_RS05480	COG2801	Transposase and inactivated derivatives
EG343_RS05480	COG3415	Transposase
EG343_RS05590	COG1074	ATP-dependent DNA helicase activity
EG343_RS05595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EG343_RS05655	COG4974	Belongs to the 'phage' integrase family
EG343_RS05670	COG3831	ATPase activity
EG343_RS05670	COG4884	unkown
EG343_RS05675	COG4221	oxidoreductase activity
EG343_RS05745	COG2079	MmgE PrpD family protein
EG343_RS05755	COG1960	acyl-CoA dehydrogenase activity
EG343_RS05760	COG1024	Enoyl-CoA hydratase
EG343_RS05770	COG1024	Enoyl-CoA hydratase
EG343_RS05775	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EG343_RS05790	COG1566	PFAM secretion protein HlyD family protein
EG343_RS05795	COG1131	(ABC) transporter
EG343_RS05800	COG1131	(ABC) transporter
EG343_RS05805	COG0842	Transport permease protein
EG343_RS05810	COG1129	ABC transporter
EG343_RS05810	COG0842	Transport permease protein
EG343_RS05840	COG1335	isochorismatase
EG343_RS05850	COG0730	response to heat
EG343_RS05855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EG343_RS05860	COG4771	TonB-dependent receptor
EG343_RS05890	COG2972	Histidine kinase
EG343_RS05890	COG0745	RESPONSE REGULATOR receiver
EG343_RS05895	COG3279	Response regulator of the LytR AlgR family
EG343_RS05905	COG1131	(ABC) transporter
EG343_RS05925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EG343_RS05945	COG1090	epimerase
EG343_RS05990	COG4206	TonB-dependent receptor
EG343_RS05990	COG1629	transport
EG343_RS06020	COG1902	pentaerythritol trinitrate reductase activity
EG343_RS06025	COG1733	regulation of RNA biosynthetic process
EG343_RS06030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EG343_RS06040	COG0022	dehydrogenase e1 component
EG343_RS06050	COG0142	geranyltranstransferase activity
EG343_RS06065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EG343_RS06075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EG343_RS06095	COG0673	inositol 2-dehydrogenase activity
EG343_RS06115	COG0823	Involved in the tonB-independent uptake of proteins
EG343_RS06115	COG1506	peptidase
EG343_RS06120	COG1950	PFAM Membrane protein of
EG343_RS06135	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS06140	COG3292	Two component regulator propeller
EG343_RS06140	COG2205	protein histidine kinase activity
EG343_RS06140	COG0745	RESPONSE REGULATOR receiver
EG343_RS06160	COG1846	Transcriptional regulator
EG343_RS06170	COG0697	spore germination
EG343_RS06175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EG343_RS06180	COG2011	ABC-type metal ion transport system permease component
EG343_RS06185	COG1464	Belongs to the NlpA lipoprotein family
EG343_RS06190	COG1472	Belongs to the glycosyl hydrolase 3 family
EG343_RS06215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS06250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EG343_RS06320	COG0604	alcohol dehydrogenase
EG343_RS06320	COG3321	synthase
EG343_RS06325	COG4221	oxidoreductase activity
EG343_RS06325	COG3321	synthase
EG343_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS06325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EG343_RS06330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EG343_RS06375	COG0542	response to heat
EG343_RS06535	COG2197	response regulator
EG343_RS06540	COG4585	Histidine kinase
EG343_RS06555	COG1280	lysine exporter protein (LysE YggA)
EG343_RS06590	COG0006	proline dipeptidase activity
EG343_RS06630	COG0829	nickel cation binding
EG343_RS06635	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EG343_RS06640	COG0830	nickel cation binding
EG343_RS06645	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EG343_RS06655	COG0804	urea catabolic process
EG343_RS06660	COG0832	Belongs to the urease beta subunit family
EG343_RS06665	COG0831	urea catabolic process
EG343_RS06675	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS06705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG343_RS06710	COG0598	Magnesium transport protein CorA
EG343_RS06730	COG2249	NAD(P)H dehydrogenase (quinone) activity
EG343_RS06735	COG1733	regulation of RNA biosynthetic process
EG343_RS06745	COG2818	Glycosylase
EG343_RS06770	COG2814	Major facilitator Superfamily
EG343_RS06785	COG1309	transcriptional regulator
EG343_RS06815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EG343_RS06850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EG343_RS06885	COG0748	coenzyme F420 binding
EG343_RS06890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EG343_RS06900	COG4682	membrane
EG343_RS06910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EG343_RS06915	COG0697	spore germination
EG343_RS06920	COG0657	acetylesterase activity
EG343_RS06920	COG2755	lipolytic protein G-D-S-L family
EG343_RS06930	COG0475	glutathione-regulated potassium exporter activity
EG343_RS06930	COG0589	response to stress
EG343_RS06940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EG343_RS06950	COG0730	response to heat
EG343_RS06960	COG0346	lactoylglutathione lyase activity
EG343_RS06980	COG1022	Amp-dependent synthetase and ligase
EG343_RS07005	COG2267	carboxylic ester hydrolase activity
EG343_RS07010	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EG343_RS07015	COG0668	transmembrane transport
EG343_RS07035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG343_RS07060	COG1607	acyl-coa hydrolase
EG343_RS07100	COG1169	isochorismate synthase
EG343_RS07115	COG2095	MarC family integral membrane protein
EG343_RS07135	COG2304	oxidoreductase activity
EG343_RS07155	COG0714	Associated with various cellular activities
EG343_RS07185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG343_RS07220	COG0492	ferredoxin-NADP+ reductase activity
EG343_RS07230	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS07230	COG2207	Transcriptional regulator
EG343_RS07235	COG4716	Myosin-crossreactive antigen
EG343_RS07240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EG343_RS07260	COG4948	Mandelate Racemase Muconate Lactonizing
EG343_RS07265	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EG343_RS07270	COG0527	aspartate kinase activity
EG343_RS07350	COG1876	peptidase activity
EG343_RS07390	COG0702	epimerase
EG343_RS07395	COG4206	TonB-dependent receptor
EG343_RS07395	COG1629	transport
EG343_RS07405	COG3275	phosphorelay sensor kinase activity
EG343_RS07420	COG1733	regulation of RNA biosynthetic process
EG343_RS07425	COG3118	belongs to the thioredoxin family
EG343_RS07440	COG3876	Protein conserved in bacteria
EG343_RS07470	COG1301	dicarboxylic acid transport
EG343_RS07485	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS07500	COG4771	TonB-dependent receptor
EG343_RS07510	COG4771	TonB-dependent receptor
EG343_RS07560	COG5002	protein histidine kinase activity
EG343_RS07565	COG0745	RESPONSE REGULATOR receiver
EG343_RS07580	COG0402	S-adenosylhomocysteine deaminase activity
EG343_RS07590	COG0666	response to abiotic stimulus
EG343_RS07595	COG0402	S-adenosylhomocysteine deaminase activity
EG343_RS07610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EG343_RS07620	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EG343_RS07655	COG1902	pentaerythritol trinitrate reductase activity
EG343_RS07660	COG0295	cytidine deaminase activity
EG343_RS07665	COG2732	(Barnase) inhibitor
EG343_RS07680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EG343_RS07690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG343_RS07710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG343_RS07720	COG0626	cystathionine gamma-synthase activity
EG343_RS07745	COG0009	L-threonylcarbamoyladenylate synthase
EG343_RS07755	COG0617	tRNA 3'-terminal CCA addition
EG343_RS07770	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
EG343_RS07790	COG2234	aminopeptidase activity
EG343_RS07855	COG4251	negative regulation of phosphorylation
EG343_RS07870	COG0471	metal ion transport
EG343_RS07880	COG1053	succinate dehydrogenase
EG343_RS07885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EG343_RS08010	COG1733	regulation of RNA biosynthetic process
EG343_RS08035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS08040	COG4977	sequence-specific DNA binding
EG343_RS08050	COG0443	Heat shock 70 kDa protein
EG343_RS08080	COG0248	Ppx GppA phosphatase
EG343_RS08105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EG343_RS08110	COG0489	protein tyrosine kinase activity
EG343_RS08135	COG1301	dicarboxylic acid transport
EG343_RS08170	COG0010	Belongs to the arginase family
EG343_RS08175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EG343_RS08185	COG2365	Tyrosine phosphatase family
EG343_RS08210	COG2378	regulation of single-species biofilm formation
EG343_RS08215	COG1132	(ABC) transporter
EG343_RS08225	COG1137	ATPase activity
EG343_RS08240	COG0113	porphobilinogen synthase activity
EG343_RS08250	COG4152	abc transporter atp-binding protein
EG343_RS08255	COG1668	transmembrane transport
EG343_RS08265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EG343_RS08270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG343_RS08275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EG343_RS08280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG343_RS08285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EG343_RS08285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EG343_RS08290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG343_RS08295	COG1078	dGTPase activity
EG343_RS08315	COG0708	Exodeoxyribonuclease III
EG343_RS08320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EG343_RS08335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG343_RS08345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EG343_RS08350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EG343_RS08370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EG343_RS08375	COG0297	glycogen (starch) synthase activity
EG343_RS08395	COG1086	Polysaccharide biosynthesis protein
EG343_RS08425	COG0438	transferase activity, transferring glycosyl groups
EG343_RS08445	COG3206	protein involved in exopolysaccharide biosynthesis
EG343_RS08445	COG0489	protein tyrosine kinase activity
EG343_RS08450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EG343_RS08465	COG2137	regulation of response to DNA damage stimulus
EG343_RS08470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EG343_RS08495	COG1136	(ABC) transporter
EG343_RS08495	COG0577	efflux transmembrane transporter activity
EG343_RS08500	COG1136	(ABC) transporter
EG343_RS08550	COG1418	mRNA catabolic process
EG343_RS08560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EG343_RS08570	COG0525	valine-tRNA ligase activity
EG343_RS08580	COG2326	polyphosphate kinase activity
EG343_RS08600	COG0318	PFAM AMP-dependent synthetase and ligase
EG343_RS08610	COG0017	Asparaginyl-tRNA synthetase
EG343_RS08635	COG4977	sequence-specific DNA binding
EG343_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS08655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EG343_RS08660	COG0228	four-way junction DNA binding
EG343_RS08685	COG0339	signal peptide processing
EG343_RS08710	COG2226	methyltransferase
EG343_RS08715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS08725	COG0477	Major facilitator Superfamily
EG343_RS08730	COG1309	transcriptional regulator
EG343_RS08780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EG343_RS08805	COG4245	von Willebrand factor, type A
EG343_RS08820	COG2310	stress, protein
EG343_RS08830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EG343_RS08840	COG0259	pyridoxamine-phosphate oxidase activity
EG343_RS08845	COG1678	Uncharacterized ACR, COG1678
EG343_RS08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EG343_RS08865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EG343_RS08880	COG3158	transport of potassium into the cell
EG343_RS08885	COG0022	dehydrogenase e1 component
EG343_RS08885	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG343_RS08900	COG1183	phosphatidylcholine synthase activity
EG343_RS08920	COG0589	response to stress
EG343_RS08945	COG0544	peptidyl-prolyl cis-trans isomerase activity
EG343_RS08965	COG0488	(ABC) transporter
EG343_RS08980	COG4585	Histidine kinase
EG343_RS09015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG343_RS09020	COG0720	synthase
EG343_RS09055	COG2224	Isocitrate lyase
EG343_RS09060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EG343_RS09070	COG1040	competence protein
EG343_RS09080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EG343_RS09095	COG1160	GTP binding
EG343_RS09120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EG343_RS09145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EG343_RS09160	COG0745	RESPONSE REGULATOR receiver
EG343_RS09170	COG5006	permease, DMT superfamily
EG343_RS09175	COG1285	pathogenesis
EG343_RS09210	COG0436	Aminotransferase
EG343_RS09220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EG343_RS09240	COG1858	cytochrome C peroxidase
EG343_RS09255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EG343_RS09265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EG343_RS09270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EG343_RS09280	COG0251	oxidation-reduction process
EG343_RS09285	COG0552	protein localization to endoplasmic reticulum
EG343_RS09295	COG0616	signal peptide processing
EG343_RS09325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EG343_RS09335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG343_RS09335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG343_RS09340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EG343_RS09360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EG343_RS09370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EG343_RS09385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EG343_RS09405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS09425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EG343_RS09425	COG2207	Transcriptional regulator
EG343_RS09440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS09455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EG343_RS09460	COG1561	YicC-like family, N-terminal region
EG343_RS09465	COG0194	GDP metabolic process
EG343_RS09470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EG343_RS09490	COG0460	homoserine dehydrogenase
EG343_RS09490	COG0527	aspartate kinase activity
EG343_RS09495	COG0083	homoserine kinase activity
EG343_RS09500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EG343_RS09505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EG343_RS09540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EG343_RS09560	COG0284	orotidine-5'-phosphate decarboxylase activity
EG343_RS09560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EG343_RS09600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EG343_RS09605	COG1522	sequence-specific DNA binding
EG343_RS09615	COG0336	Belongs to the RNA methyltransferase TrmD family
EG343_RS09620	COG1252	NADH dehydrogenase
EG343_RS09630	COG0596	Alpha beta hydrolase
EG343_RS09640	COG0488	(ABC) transporter
EG343_RS09645	COG0673	inositol 2-dehydrogenase activity
EG343_RS09650	COG4206	TonB-dependent receptor
EG343_RS09665	COG0450	alkyl hydroperoxide reductase
EG343_RS09675	COG0045	succinate-CoA ligase (ADP-forming) activity
EG343_RS09685	COG1132	(ABC) transporter
EG343_RS09690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS09700	COG0038	chloride channel
EG343_RS09705	COG2363	Small membrane protein
EG343_RS09815	COG0740	serine-type endopeptidase activity
EG343_RS09875	COG1876	peptidase activity
EG343_RS09975	COG1733	regulation of RNA biosynthetic process
EG343_RS09985	COG0205	6-phosphofructokinase activity
EG343_RS10000	COG2197	response regulator
EG343_RS10015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EG343_RS10055	COG0326	Molecular chaperone. Has ATPase activity
EG343_RS10070	COG1899	peptidyl-lysine modification to peptidyl-hypusine
EG343_RS10085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EG343_RS10090	COG0318	PFAM AMP-dependent synthetase and ligase
EG343_RS10155	COG1113	amino acid transport
EG343_RS10190	COG0018	arginyl-trna synthetase
EG343_RS10205	COG4771	TonB-dependent receptor
EG343_RS10210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EG343_RS10215	COG0706	membrane insertase activity
EG343_RS10220	COG0504	CTP synthase activity
EG343_RS10235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EG343_RS10240	COG2207	Transcriptional regulator
EG343_RS10240	COG4753	response regulator
EG343_RS10245	COG2226	methyltransferase
EG343_RS10265	COG1404	Belongs to the peptidase S8 family
EG343_RS10280	COG3279	Response regulator of the LytR AlgR family
EG343_RS10295	COG2851	Citrate transporter
EG343_RS10300	COG1301	dicarboxylic acid transport
EG343_RS10310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EG343_RS10390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS10395	COG0494	nUDIX hydrolase
EG343_RS10420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EG343_RS10455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS10465	COG2318	DinB family
EG343_RS10490	COG2267	carboxylic ester hydrolase activity
EG343_RS10535	COG0745	RESPONSE REGULATOR receiver
EG343_RS10540	COG5002	protein histidine kinase activity
EG343_RS10550	COG0477	Major facilitator Superfamily
EG343_RS10565	COG1595	DNA-templated transcription, initiation
EG343_RS10585	COG1132	(ABC) transporter
EG343_RS10595	COG0101	tRNA pseudouridine synthase activity
EG343_RS10600	COG1663	tetraacyldisaccharide 4'-kinase activity
EG343_RS10610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG343_RS10615	COG0456	acetyltransferase
EG343_RS10620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG343_RS10645	COG1064	alcohol dehydrogenase
EG343_RS10650	COG1733	regulation of RNA biosynthetic process
EG343_RS10715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EG343_RS10720	COG0085	RNA polymerase activity
EG343_RS10740	COG0222	ribosome binding
EG343_RS10745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EG343_RS10750	COG0081	regulation of translation
EG343_RS10755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EG343_RS10865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EG343_RS10870	COG4974	Belongs to the 'phage' integrase family
EG343_RS10875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EG343_RS11170	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
EG343_RS11190	COG1061	Type III restriction enzyme res subunit
EG343_RS11290	COG0431	NADPH-dependent FMN reductase
EG343_RS11300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EG343_RS11305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EG343_RS11310	COG0571	ribonuclease III activity
EG343_RS11320	COG0469	pyruvate kinase activity
EG343_RS11330	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS11335	COG0010	Belongs to the arginase family
EG343_RS11340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EG343_RS11355	COG2255	four-way junction helicase activity
EG343_RS11365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS11370	COG0237	dephospho-CoA kinase activity
EG343_RS11390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EG343_RS11400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EG343_RS11405	COG1053	succinate dehydrogenase
EG343_RS11415	COG0658	competence protein
EG343_RS11415	COG2333	competence protein COMEC
EG343_RS11425	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EG343_RS11445	COG0534	Mate efflux family protein
EG343_RS11450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EG343_RS11455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EG343_RS11465	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EG343_RS11475	COG3285	dna ligase
EG343_RS11475	COG1793	dna ligase
EG343_RS11480	COG0668	transmembrane transport
EG343_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS11490	COG1862	Preprotein translocase
EG343_RS11500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EG343_RS11505	COG1132	(ABC) transporter
EG343_RS11530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EG343_RS11555	COG0848	biopolymer transport protein
EG343_RS11570	COG0495	leucyl-tRNA aminoacylation
EG343_RS11585	COG1215	transferase activity, transferring glycosyl groups
EG343_RS11595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EG343_RS11595	COG1519	Transferase
EG343_RS11620	COG0037	tRNA processing
EG343_RS11665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EG343_RS11670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EG343_RS11675	COG2884	Cell division ATP-binding protein ftsE
EG343_RS11680	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EG343_RS11685	COG5000	phosphorelay sensor kinase activity
EG343_RS11695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EG343_RS11705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EG343_RS11710	COG0511	ligase activity, forming carbon-carbon bonds
EG343_RS11715	COG0439	Biotin carboxylase
EG343_RS11740	COG1215	transferase activity, transferring glycosyl groups
EG343_RS11745	COG0463	Glycosyl transferase, family 2
EG343_RS11745	COG1216	Glycosyl transferase, family 2
EG343_RS11755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EG343_RS11760	COG0825	malonyl-CoA metabolic process
EG343_RS11770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EG343_RS11800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EG343_RS11820	COG0052	Belongs to the universal ribosomal protein uS2 family
EG343_RS11825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EG343_RS11830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EG343_RS11850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG343_RS11850	COG1703	isobutyryl-CoA mutase activity
EG343_RS11850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG343_RS11865	COG0076	glutamate decarboxylase activity
EG343_RS11895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EG343_RS11905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG343_RS11920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EG343_RS11930	COG0517	IMP dehydrogenase activity
EG343_RS11930	COG0516	GMP reductase activity
EG343_RS11955	COG1595	DNA-templated transcription, initiation
EG343_RS11995	COG0254	rRNA binding
EG343_RS12010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EG343_RS12035	COG0702	epimerase
EG343_RS12040	COG1629	transport
EG343_RS12045	COG0300	oxidoreductase activity
EG343_RS12055	COG4771	TonB-dependent receptor
EG343_RS12065	COG3511	phospholipase C
EG343_RS12100	COG4771	TonB-dependent receptor
EG343_RS12180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EG343_RS12185	COG1442	glycosyl transferase family 8
EG343_RS12185	COG1216	Glycosyl transferase, family 2
EG343_RS12230	COG2409	Drug exporters of the RND superfamily
EG343_RS12240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG343_RS12255	COG0612	Peptidase, M16
EG343_RS12270	COG1131	(ABC) transporter
EG343_RS12285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EG343_RS12300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EG343_RS12325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EG343_RS12345	COG0644	oxidoreductase
EG343_RS12355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EG343_RS12360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EG343_RS12365	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS12370	COG2986	histidine ammonia-lyase
EG343_RS12385	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EG343_RS12390	COG0739	heme binding
EG343_RS12395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EG343_RS12400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EG343_RS12415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EG343_RS12420	COG2949	membrane
EG343_RS12425	COG0180	Tryptophanyl-tRNA synthetase
EG343_RS12430	COG5002	protein histidine kinase activity
EG343_RS12435	COG0745	RESPONSE REGULATOR receiver
EG343_RS12450	COG0546	phosphoglycolate phosphatase activity
EG343_RS12465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EG343_RS12480	COG1024	Enoyl-CoA hydratase
EG343_RS12490	COG4974	Belongs to the 'phage' integrase family
EG343_RS12510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS12520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG343_RS12525	COG1607	acyl-coa hydrolase
EG343_RS12550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EG343_RS12570	COG2022	thiamine diphosphate biosynthetic process
EG343_RS12575	COG0352	thiamine-phosphate diphosphorylase activity
EG343_RS12580	COG0352	thiamine-phosphate diphosphorylase activity
EG343_RS12600	COG0564	pseudouridine synthase activity
EG343_RS12610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EG343_RS12620	COG2217	Heavy metal translocating P-type atpase
EG343_RS12645	COG0348	domain, Protein
EG343_RS12665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EG343_RS12680	COG0438	transferase activity, transferring glycosyl groups
EG343_RS12700	COG0247	lactate metabolic process
EG343_RS12700	COG2181	nitrate reductase activity
EG343_RS12705	COG0247	lactate metabolic process
EG343_RS12705	COG2181	nitrate reductase activity
EG343_RS12715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EG343_RS12720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EG343_RS12740	COG1960	acyl-CoA dehydrogenase activity
EG343_RS12770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EG343_RS12775	COG0602	queuosine metabolic process
EG343_RS12780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EG343_RS12785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EG343_RS12790	COG1127	ABC transporter
EG343_RS12815	COG1703	isobutyryl-CoA mutase activity
EG343_RS12845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EG343_RS12855	COG1690	Belongs to the RtcB family
EG343_RS12870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG343_RS12870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG343_RS12885	COG1505	serine-type exopeptidase activity
EG343_RS12895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EG343_RS12900	COG0531	amino acid
EG343_RS12910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EG343_RS12920	COG1609	Transcriptional regulator
EG343_RS12920	COG2207	Transcriptional regulator
EG343_RS12930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EG343_RS12930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EG343_RS12955	COG1131	(ABC) transporter
EG343_RS12965	COG0497	DNA recombination
EG343_RS13000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EG343_RS13005	COG0594	ribonuclease P activity
EG343_RS13030	COG3829	transcription factor binding
EG343_RS13045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG343_RS13060	COG0028	Belongs to the TPP enzyme family
EG343_RS13070	COG2176	DNA-directed DNA polymerase activity
EG343_RS13075	COG0433	COG0433 Predicted ATPase
EG343_RS13080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS13080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG343_RS13090	COG3118	belongs to the thioredoxin family
EG343_RS13095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EG343_RS13105	COG0750	zinc metalloprotease
EG343_RS13190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EG343_RS13195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EG343_RS13225	COG3033	Beta-eliminating lyase
EG343_RS13235	COG0436	Aminotransferase
EG343_RS13245	COG2133	pyrroloquinoline quinone binding
EG343_RS13250	COG0556	nucleotide-excision repair
EG343_RS13255	COG3530	Putative quorum-sensing-regulated virulence factor
EG343_RS13280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EG343_RS13285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EG343_RS13340	COG0653	protein targeting
EG343_RS13350	COG4771	TonB-dependent receptor
EG343_RS13375	COG1940	carbohydrate kinase activity
EG343_RS13380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG343_RS13405	COG3422	double-strand break repair
EG343_RS13420	COG2153	protein acetylation
EG343_RS13425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EG343_RS13435	COG2001	Belongs to the MraZ family
EG343_RS13440	COG0275	rRNA processing
EG343_RS13450	COG0768	penicillin binding
EG343_RS13455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EG343_RS13465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EG343_RS13470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EG343_RS13480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EG343_RS13485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EG343_RS13500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EG343_RS13505	COG1610	YqeY-like protein
EG343_RS13545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EG343_RS13565	COG0745	RESPONSE REGULATOR receiver
EG343_RS13585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EG343_RS13590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EG343_RS13605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EG343_RS13620	COG2255	four-way junction helicase activity
EG343_RS13655	COG4773	Receptor
EG343_RS13695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EG343_RS13700	COG0697	spore germination
EG343_RS13710	COG0604	alcohol dehydrogenase
EG343_RS13720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EG343_RS13775	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EG343_RS13790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EG343_RS13845	COG0481	GTPase activity
EG343_RS13860	COG1595	DNA-templated transcription, initiation
EG343_RS13870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EG343_RS13875	COG0424	maF-like protein
EG343_RS13885	COG1214	PFAM Peptidase M22, glycoprotease
EG343_RS13890	COG4221	oxidoreductase activity
EG343_RS13895	COG0792	nuclease activity
EG343_RS13900	COG1619	proteins homologs of microcin C7 resistance protein MccF
EG343_RS13910	COG0557	exoribonuclease II activity
EG343_RS13920	COG0698	ribose 5-phosphate isomerase
EG343_RS13925	COG0126	phosphoglycerate kinase activity
EG343_RS13935	COG0445	tRNA wobble uridine modification
EG343_RS13940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EG343_RS13950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EG343_RS13955	COG1435	thymidine kinase activity
EG343_RS13965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EG343_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS14000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EG343_RS14010	COG0793	Belongs to the peptidase S41A family
EG343_RS14015	COG2032	superoxide dismutase activity
EG343_RS14025	COG4771	TonB-dependent receptor
EG343_RS14035	COG3275	phosphorelay sensor kinase activity
EG343_RS14060	COG3279	Response regulator of the LytR AlgR family
EG343_RS14090	COG0482	sulfurtransferase activity
EG343_RS14115	COG2166	iron-sulfur cluster assembly
EG343_RS14175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EG343_RS14180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EG343_RS14200	COG0811	peptide transport
EG343_RS14225	COG2715	membrane protein required for spore maturation
EG343_RS14240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EG343_RS14250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EG343_RS14260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG343_RS14275	COG3781	membrane
EG343_RS14285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG343_RS14290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EG343_RS14330	COG2081	HI0933 family
EG343_RS14340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EG343_RS14350	COG2814	Major facilitator Superfamily
EG343_RS14360	COG3279	Response regulator of the LytR AlgR family
EG343_RS14385	COG2195	Cleaves the N-terminal amino acid of tripeptides
EG343_RS14400	COG2151	metal-sulfur cluster biosynthetic enzyme
EG343_RS14410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EG343_RS14435	COG3279	Response regulator of the LytR AlgR family
EG343_RS14445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS14465	COG1595	DNA-templated transcription, initiation
EG343_RS14490	COG0606	chelatase, subunit chli
EG343_RS14545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG343_RS14550	COG0587	DNA-directed DNA polymerase activity
EG343_RS14615	COG0606	chelatase, subunit chli
EG343_RS14635	COG3591	Belongs to the peptidase S1B family
EG343_RS14645	COG3279	Response regulator of the LytR AlgR family
EG343_RS14650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EG343_RS14690	COG0387	Pfam Sodium calcium exchanger
EG343_RS14720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EG343_RS14730	COG0758	DNA mediated transformation
EG343_RS14750	COG0719	Fe-S assembly protein
EG343_RS14755	COG0396	ATPase activity
EG343_RS14760	COG2351	hydroxyisourate hydrolase activity
EG343_RS14765	COG0719	Fe-S assembly protein
EG343_RS14770	COG0316	Belongs to the HesB IscA family
EG343_RS14785	COG2321	neutral zinc metallopeptidase
EG343_RS14795	COG1368	sulfuric ester hydrolase activity
EG343_RS14800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EG343_RS14840	COG0437	4 iron, 4 sulfur cluster binding
EG343_RS14865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EG343_RS14870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EG343_RS14880	COG1774	PSP1 C-terminal conserved region
EG343_RS14895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EG343_RS14900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EG343_RS14915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EG343_RS14930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EG343_RS14950	COG0768	penicillin binding
EG343_RS14955	COG0772	Belongs to the SEDS family
EG343_RS14965	COG0791	NLP P60 protein
EG343_RS14995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG343_RS15040	COG3621	Patatin-like phospholipase
EG343_RS15045	COG1876	peptidase activity
EG343_RS15105	COG0423	glycine-tRNA ligase activity
EG343_RS15110	COG0564	pseudouridine synthase activity
EG343_RS15115	COG0167	dihydroorotate dehydrogenase activity
EG343_RS15125	COG2733	membrane
EG343_RS15130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG343_RS15140	COG5002	protein histidine kinase activity
EG343_RS15145	COG0745	RESPONSE REGULATOR receiver
EG343_RS15170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EG343_RS15185	COG1764	response to oxidative stress
EG343_RS15190	COG2169	Transcriptional regulator
EG343_RS15195	COG4771	TonB-dependent receptor
EG343_RS15210	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EG343_RS15215	COG3537	Alpha-1,2-mannosidase
EG343_RS15285	COG1770	oligopeptidase
EG343_RS15300	COG0463	Glycosyl transferase, family 2
EG343_RS15310	COG0343	queuine tRNA-ribosyltransferase activity
EG343_RS15320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EG343_RS15320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EG343_RS15325	COG0799	negative regulation of ribosome biogenesis
EG343_RS15330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG343_RS15345	COG0688	phosphatidylethanolamine metabolic process
EG343_RS15375	COG1132	(ABC) transporter
EG343_RS15395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EG343_RS15400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EG343_RS15440	COG1611	Belongs to the LOG family
EG343_RS15445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EG343_RS15470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EG343_RS15475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EG343_RS15505	COG0778	Nitroreductase
EG343_RS15520	COG0328	RNA-DNA hybrid ribonuclease activity
EG343_RS15525	COG0305	Participates in initiation and elongation during chromosome replication
EG343_RS15565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EG343_RS15590	COG0193	aminoacyl-tRNA hydrolase activity
EG343_RS15600	COG0659	secondary active sulfate transmembrane transporter activity
EG343_RS15610	COG0288	reversible hydration of carbon dioxide
EG343_RS15635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EG343_RS15640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG343_RS15650	COG0438	transferase activity, transferring glycosyl groups
EG343_RS15655	COG1215	transferase activity, transferring glycosyl groups
EG343_RS15680	COG0463	Glycosyl transferase, family 2
EG343_RS15685	COG0463	Glycosyl transferase, family 2
EG343_RS15690	COG0463	Glycosyl transferase, family 2
EG343_RS15695	COG0367	asparagine synthase
EG343_RS15775	COG1216	Glycosyl transferase, family 2
EG343_RS15810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EG343_RS15815	COG0779	Required for maturation of 30S ribosomal subunits
EG343_RS15820	COG0195	Participates in both transcription termination and antitermination
EG343_RS15825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EG343_RS15830	COG1629	transport
EG343_RS15850	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EG343_RS15870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EG343_RS15880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EG343_RS15920	COG1629	transport
EG343_RS15945	COG3781	membrane
EG343_RS15960	COG2217	Heavy metal translocating P-type atpase
EG343_RS15980	COG1999	signal sequence binding
EG343_RS15985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EG343_RS16060	COG0268	Binds directly to 16S ribosomal RNA
EG343_RS16085	COG0251	oxidation-reduction process
EG343_RS16095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EG343_RS16100	COG1054	Belongs to the UPF0176 family
EG343_RS16125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG343_RS16195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EG343_RS16200	COG0783	Belongs to the Dps family
EG343_RS16215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EG343_RS16220	COG0049	tRNA binding
EG343_RS16225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EG343_RS16230	COG0051	transcription antitermination factor activity, RNA binding
EG343_RS16260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EG343_RS16265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EG343_RS16270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EG343_RS16275	COG1349	DNA-binding transcription factor activity
EG343_RS16280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EG343_RS16285	COG0088	Forms part of the polypeptide exit tunnel
EG343_RS16290	COG0089	rRNA binding
EG343_RS16295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EG343_RS16300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EG343_RS16305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EG343_RS16310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EG343_RS16315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EG343_RS16320	COG0255	Belongs to the universal ribosomal protein uL29 family
EG343_RS16325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EG343_RS16330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EG343_RS16340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EG343_RS16345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EG343_RS16350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EG343_RS16355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EG343_RS16360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EG343_RS16365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EG343_RS16370	COG1841	ribosomal large subunit assembly
EG343_RS16375	COG0200	Binds to the 23S rRNA
EG343_RS16385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EG343_RS16390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EG343_RS16395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EG343_RS16400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EG343_RS16405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EG343_RS16410	COG0202	RNA polymerase activity
EG343_RS16415	COG0203	ribosomal protein L17
EG343_RS16425	COG2197	response regulator
EG343_RS16440	COG4585	Histidine kinase
EG343_RS16460	COG0148	phosphopyruvate hydratase activity
EG343_RS16480	COG1834	amidinotransferase
EG343_RS16505	COG0085	RNA polymerase activity
EG343_RS16515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EG343_RS16520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EG343_RS16520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EG343_RS16525	COG0501	Belongs to the peptidase M48B family
EG343_RS16530	COG0488	(ABC) transporter
EG343_RS16535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EG343_RS16545	COG0217	transcriptional regulatory protein
EG343_RS16590	COG0714	Associated with various cellular activities
EG343_RS16610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EG343_RS16615	COG0460	homoserine dehydrogenase
EG343_RS16615	COG0527	aspartate kinase activity
EG343_RS16625	COG1410	methionine synthase
EG343_RS16625	COG0646	methionine synthase
EG343_RS16640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EG343_RS16650	COG0302	gtp cyclohydrolase
EG343_RS16660	COG0215	cysteine-tRNA ligase activity
EG343_RS16720	COG1640	4-alpha-glucanotransferase
EG343_RS16735	COG1528	Iron-storage protein
EG343_RS16745	COG1074	ATP-dependent DNA helicase activity
EG343_RS16785	COG0438	transferase activity, transferring glycosyl groups
EG343_RS16790	COG1472	Belongs to the glycosyl hydrolase 3 family
EG343_RS16800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG343_RS16815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EG343_RS16830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EG343_RS16840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EG343_RS16845	COG3537	Alpha-1,2-mannosidase
EG343_RS16865	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS16915	COG2197	response regulator
EG343_RS16920	COG4585	Histidine kinase
EG343_RS16935	COG0542	response to heat
EG343_RS16940	COG1309	transcriptional regulator
EG343_RS16950	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EG343_RS16955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EG343_RS16960	COG3396	Phenylacetate-CoA oxygenase
EG343_RS16965	COG3460	Phenylacetate-CoA oxygenase
EG343_RS16975	COG2151	metal-sulfur cluster biosynthetic enzyme
EG343_RS16980	COG1024	Enoyl-CoA hydratase
EG343_RS16985	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG343_RS17000	COG0183	Belongs to the thiolase family
EG343_RS17020	COG1012	belongs to the aldehyde dehydrogenase family
EG343_RS17020	COG2030	dehydratase
EG343_RS17105	COG1404	Belongs to the peptidase S8 family
EG343_RS17105	COG4935	Belongs to the peptidase S8 family
EG343_RS17115	COG1490	D-aminoacyl-tRNA deacylase activity
EG343_RS17125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EG343_RS17135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EG343_RS17205	COG1505	serine-type exopeptidase activity
EG343_RS17250	COG0281	malic enzyme
EG343_RS17250	COG0280	phosphate acetyltransferase
EG343_RS17260	COG0632	four-way junction helicase activity
EG343_RS17285	COG0509	glycine decarboxylation via glycine cleavage system
EG343_RS17330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EG343_RS17360	COG0322	excinuclease ABC activity
EG343_RS17370	COG2986	histidine ammonia-lyase
EG343_RS17380	COG1404	Belongs to the peptidase S8 family
EG343_RS17390	COG3384	dioxygenase
EG343_RS17395	COG2353	YceI-like domain
EG343_RS17400	COG0823	Involved in the tonB-independent uptake of proteins
EG343_RS17400	COG1506	peptidase
EG343_RS17415	COG0419	ATPase involved in DNA repair
EG343_RS17420	COG0420	3'-5' exonuclease activity
EG343_RS17430	COG4628	conserved protein (DUF2132)
EG343_RS17435	COG1047	Peptidyl-prolyl cis-trans
EG343_RS17445	COG3012	SEC-C Motif Domain Protein
EG343_RS17460	COG0339	signal peptide processing
EG343_RS17490	COG1704	LemA family
EG343_RS17495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EG343_RS17510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EG343_RS17515	COG1181	Belongs to the D-alanine--D-alanine ligase family
EG343_RS17525	COG0564	pseudouridine synthase activity
EG343_RS17535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EG343_RS17550	COG1733	regulation of RNA biosynthetic process
EG343_RS17585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG343_RS17590	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EG343_RS17605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS17620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EG343_RS17625	COG0242	peptide deformylase activity
EG343_RS17635	COG3956	TIGRFAM MazG family protein
EG343_RS17690	COG1007	ATP synthesis coupled electron transport
EG343_RS17695	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG343_RS17700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EG343_RS17710	COG0839	Belongs to the complex I subunit 6 family
EG343_RS17715	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG343_RS17720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EG343_RS17725	COG1034	ATP synthesis coupled electron transport
EG343_RS17735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EG343_RS17740	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EG343_RS17745	COG0649	NAD binding
EG343_RS17750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG343_RS17755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG343_RS17760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG343_RS17775	COG1739	Uncharacterized protein family UPF0029
EG343_RS17785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG343_RS17785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG343_RS17795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EG343_RS17810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EG343_RS17815	COG0346	lactoylglutathione lyase activity
EG343_RS17905	COG4974	Belongs to the 'phage' integrase family
EG343_RS17920	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS17920	COG2207	Transcriptional regulator
EG343_RS17925	COG1073	alpha beta
EG343_RS17930	COG0025	NhaP-type Na H and K H
EG343_RS17965	COG0813	purine-nucleoside phosphorylase activity
EG343_RS17970	COG0346	lactoylglutathione lyase activity
EG343_RS17980	COG0714	Associated with various cellular activities
EG343_RS18100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EG343_RS18105	COG0596	Alpha beta hydrolase
EG343_RS18160	COG0659	secondary active sulfate transmembrane transporter activity
EG343_RS18165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EG343_RS18180	COG2310	stress, protein
EG343_RS18185	COG3853	Toxic anion resistance protein (TelA)
EG343_RS18240	COG1959	2 iron, 2 sulfur cluster binding
EG343_RS18245	COG0702	epimerase
EG343_RS18255	COG0739	heme binding
EG343_RS18260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EG343_RS18280	COG0579	oxidoreductase
EG343_RS18305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG343_RS18330	COG0737	Belongs to the 5'-nucleotidase family
EG343_RS18335	COG0737	Belongs to the 5'-nucleotidase family
EG343_RS18340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EG343_RS18365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EG343_RS18370	COG4232	protein-disulfide reductase activity
EG343_RS18375	COG3104	oligopeptide transport
EG343_RS18390	COG3104	oligopeptide transport
EG343_RS18400	COG0823	Involved in the tonB-independent uptake of proteins
EG343_RS18400	COG1506	peptidase
EG343_RS18435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG343_RS18440	COG0069	glutamate synthase activity
EG343_RS18455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EG343_RS18475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EG343_RS18480	COG0297	glycogen (starch) synthase activity
EG343_RS18490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EG343_RS18495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EG343_RS18550	COG1538	Outer membrane efflux protein
EG343_RS18575	COG0024	Methionine aminopeptidase
EG343_RS18585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EG343_RS18650	COG0252	asparaginase activity
EG343_RS18670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EG343_RS18680	COG1522	sequence-specific DNA binding
EG343_RS18720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EG343_RS18725	COG3959	Transketolase, thiamine diphosphate binding domain
EG343_RS18740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EG343_RS18745	COG2388	GCN5-related N-acetyl-transferase
EG343_RS18765	COG0431	NADPH-dependent FMN reductase
EG343_RS18770	COG1741	Belongs to the pirin family
EG343_RS18785	COG0477	Major facilitator Superfamily
EG343_RS18795	COG0367	asparagine synthase
EG343_RS18800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EG343_RS18800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EG343_RS18805	COG2824	Alkylphosphonate utilization operon protein PhnA
EG343_RS18810	COG3842	ATPase activity
EG343_RS18820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EG343_RS18830	COG0492	ferredoxin-NADP+ reductase activity
EG343_RS18840	COG1611	Belongs to the LOG family
EG343_RS18845	COG2195	Cleaves the N-terminal amino acid of tripeptides
EG343_RS18860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EG343_RS18875	COG0612	Peptidase, M16
EG343_RS18880	COG0612	Peptidase, M16
EG343_RS18895	COG0351	phosphomethylpyrimidine kinase
EG343_RS18895	COG0352	thiamine-phosphate diphosphorylase activity
EG343_RS18895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EG343_RS18900	COG0352	thiamine-phosphate diphosphorylase activity
EG343_RS18900	COG0351	phosphomethylpyrimidine kinase
EG343_RS18905	COG0352	thiamine-phosphate diphosphorylase activity
EG343_RS18910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EG343_RS18915	COG1966	Carbon starvation protein
EG343_RS18970	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EG343_RS18980	COG0427	acetyl-CoA hydrolase
EG343_RS18985	COG0427	acetyl-CoA hydrolase
EG343_RS18990	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EG343_RS18995	COG4771	TonB-dependent receptor
EG343_RS19015	COG1733	regulation of RNA biosynthetic process
EG343_RS19020	COG4176	ABC-type proline glycine betaine transport system permease component
EG343_RS19025	COG3448	diguanylate cyclase activity
EG343_RS19025	COG4175	Glycine betaine
EG343_RS19045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EG343_RS19050	COG0667	Aldo Keto reductase
EG343_RS19070	COG2249	NAD(P)H dehydrogenase (quinone) activity
EG343_RS19085	COG0583	DNA-binding transcription factor activity
EG343_RS19090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG343_RS19095	COG0456	acetyltransferase
EG343_RS19100	COG0656	L-ascorbic acid biosynthetic process
EG343_RS19105	COG2070	2-Nitropropane dioxygenase
EG343_RS19115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EG343_RS19170	COG2197	response regulator
EG343_RS19185	COG1530	ribonuclease E activity
EG343_RS19190	COG0776	regulation of translation
EG343_RS19195	COG2197	response regulator
EG343_RS19225	COG3501	Rhs element vgr protein
EG343_RS19275	COG0542	response to heat
EG343_RS19280	COG0741	lytic transglycosylase activity
EG343_RS19290	COG3501	Rhs element vgr protein
EG343_RS19325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EG343_RS19325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EG343_RS19345	COG1285	pathogenesis
EG343_RS19355	COG4717	serine-type aminopeptidase activity
EG343_RS19370	COG0612	Peptidase, M16
EG343_RS19400	COG2204	response regulator
EG343_RS19410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EG343_RS19420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EG343_RS19430	COG2205	protein histidine kinase activity
EG343_RS19460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EG343_RS19470	COG0584	glycerophosphoryl diester phosphodiesterase
EG343_RS19475	COG4771	TonB-dependent receptor
EG343_RS19490	COG0300	oxidoreductase activity
EG343_RS19495	COG2264	protein methyltransferase activity
EG343_RS19515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS19545	COG1525	nuclease
EG343_RS19585	COG3023	N-Acetylmuramoyl-L-alanine amidase
EG343_RS19590	COG1027	Aspartate ammonia-lyase
EG343_RS19620	COG1136	(ABC) transporter
EG343_RS19620	COG0577	efflux transmembrane transporter activity
EG343_RS19625	COG1136	(ABC) transporter
EG343_RS19630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS19650	COG0306	phosphate transporter
EG343_RS19670	COG0084	hydrolase, TatD family'
EG343_RS19675	COG0513	Belongs to the DEAD box helicase family
EG343_RS19685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EG343_RS19690	COG0563	adenylate kinase activity
EG343_RS19695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EG343_RS19700	COG0488	(ABC) transporter
EG343_RS19715	COG2972	Histidine kinase
EG343_RS19720	COG3279	Response regulator of the LytR AlgR family
EG343_RS19735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EG343_RS19750	COG1192	Involved in chromosome partitioning
EG343_RS19755	COG1475	DNA binding
EG343_RS19765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EG343_RS19770	COG0681	Belongs to the peptidase S26 family
EG343_RS19800	COG0277	FAD linked oxidase domain protein
EG343_RS19820	COG1104	cysteine desulfurase activity
EG343_RS19870	COG2909	trisaccharide binding
EG343_RS19920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EG343_RS19935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EG343_RS19940	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS19940	COG2207	Transcriptional regulator
EG343_RS19945	COG2814	Major facilitator Superfamily
EG343_RS19960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EG343_RS19960	COG0723	plastoquinol--plastocyanin reductase activity
EG343_RS19980	COG3275	phosphorelay sensor kinase activity
EG343_RS20000	COG3279	Response regulator of the LytR AlgR family
EG343_RS20015	COG1058	Belongs to the CinA family
EG343_RS20015	COG1546	Belongs to the CinA family
EG343_RS20025	COG3590	peptidase
EG343_RS20030	COG3590	peptidase
EG343_RS20035	COG3590	peptidase
EG343_RS20070	COG0351	phosphomethylpyrimidine kinase
EG343_RS20075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EG343_RS20095	COG2267	carboxylic ester hydrolase activity
EG343_RS20110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EG343_RS20140	COG1538	Outer membrane efflux protein
EG343_RS20155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EG343_RS20160	COG0726	polysaccharide deacetylase
EG343_RS20200	COG3179	chitinase
EG343_RS20265	COG0656	L-ascorbic acid biosynthetic process
EG343_RS20270	COG0667	Aldo Keto reductase
EG343_RS20275	COG0667	Aldo Keto reductase
EG343_RS20295	COG1073	alpha beta
EG343_RS20315	COG0513	Belongs to the DEAD box helicase family
EG343_RS20320	COG1278	Cold shock
EG343_RS20345	COG0387	Pfam Sodium calcium exchanger
EG343_RS20380	COG0415	Belongs to the DNA photolyase family
EG343_RS20385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EG343_RS20430	COG2259	Doxx family
EG343_RS20445	COG0798	PFAM Bile acid sodium symporter
EG343_RS20450	COG0509	glycine decarboxylation via glycine cleavage system
EG343_RS20475	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EG343_RS20485	COG2132	Multicopper oxidase
EG343_RS20510	COG2217	Heavy metal translocating P-type atpase
EG343_RS20540	COG2217	Heavy metal translocating P-type atpase
EG343_RS20555	COG2217	Heavy metal translocating P-type atpase
EG343_RS20570	COG0735	belongs to the Fur family
EG343_RS20780	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EG343_RS20790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EG343_RS20815	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EG343_RS20855	COG0471	metal ion transport
EG343_RS20870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EG343_RS20875	COG2823	Periplasmic or secreted lipoprotein
EG343_RS20890	COG2823	Periplasmic or secreted lipoprotein
EG343_RS20900	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EG343_RS20920	COG4191	Histidine kinase
EG343_RS20940	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EG343_RS20955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS20960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG343_RS21040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS21040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG343_RS21060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG343_RS21095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG343_RS21130	COG3264	Mechanosensitive ion channel
EG343_RS21130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EG343_RS21155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG343_RS21165	COG1538	Outer membrane efflux protein
EG343_RS21180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG343_RS21255	COG3621	Patatin-like phospholipase
EG343_RS21275	COG4771	TonB-dependent receptor
EG343_RS21345	COG4804	nuclease activity
EG343_RS21415	COG2003	Belongs to the UPF0758 family
EG343_RS21665	COG4974	Belongs to the 'phage' integrase family
EG343_RS21675	COG0321	lipoyl(octanoyl) transferase activity
EG343_RS21675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EG343_RS21695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EG343_RS21700	COG2239	Acts as a magnesium transporter
EG343_RS21710	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EG343_RS21725	COG1185	polyribonucleotide nucleotidyltransferase activity
EG343_RS21770	COG3541	Predicted nucleotidyltransferase
EG343_RS21780	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EG343_RS21825	COG0837	glucose binding
EG343_RS21845	COG0004	ammonium transporteR
EG343_RS21850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EG343_RS21860	COG1760	l-serine dehydratase
EG343_RS21885	COG0287	Prephenate dehydrogenase
EG343_RS21915	COG3179	chitinase
EG343_RS21945	COG0475	glutathione-regulated potassium exporter activity
EG343_RS21950	COG3279	Response regulator of the LytR AlgR family
EG343_RS21970	COG0802	atpase or kinase
EG343_RS21975	COG0358	DNA primase activity
EG343_RS22000	COG2207	Transcriptional regulator
EG343_RS22000	COG4753	response regulator
EG343_RS22005	COG0149	triose-phosphate isomerase activity
EG343_RS22035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EG343_RS22045	COG0028	Belongs to the TPP enzyme family
EG343_RS22050	COG0440	acetolactate synthase activity
EG343_RS22055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EG343_RS22060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EG343_RS22065	COG2234	aminopeptidase activity
EG343_RS22065	COG4935	Belongs to the peptidase S8 family
EG343_RS22080	COG1858	cytochrome C peroxidase
EG343_RS22095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EG343_RS22100	COG1595	DNA-templated transcription, initiation
EG343_RS22110	COG3059	membrane
EG343_RS22130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG343_RS22135	COG2072	flavoprotein involved in K transport
EG343_RS22140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EG343_RS22145	COG0586	Pfam SNARE associated Golgi protein
EG343_RS22160	COG2354	Protein conserved in bacteria
EG343_RS22170	COG0484	heat shock protein binding
EG343_RS22175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EG343_RS22190	COG0442	prolyl-tRNA aminoacylation
EG343_RS22215	COG0116	Belongs to the methyltransferase superfamily
EG343_RS22225	COG0626	cystathionine gamma-synthase activity
EG343_RS22230	COG1522	sequence-specific DNA binding
EG343_RS22235	COG3781	membrane
EG343_RS22240	COG0022	dehydrogenase e1 component
EG343_RS22250	COG0587	DNA-directed DNA polymerase activity
EG343_RS22265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG343_RS22270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EG343_RS22280	COG1022	Amp-dependent synthetase and ligase
EG343_RS22285	COG1960	acyl-CoA dehydrogenase activity
EG343_RS22325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EG343_RS22330	COG1234	tRNA 3'-trailer cleavage
EG343_RS22360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EG343_RS22365	COG2177	Part of the ABC transporter FtsEX involved in
EG343_RS22375	COG1968	undecaprenyl-diphosphatase activity
EG343_RS22380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EG343_RS22385	COG1187	pseudouridine synthase activity
EG343_RS22425	COG0513	Belongs to the DEAD box helicase family
EG343_RS22440	COG0539	negative regulation of cytoplasmic translation
EG343_RS22440	COG2183	response to ionizing radiation
EG343_RS22510	COG2814	Major facilitator Superfamily
EG343_RS22525	COG0335	large ribosomal subunit rRNA binding
EG343_RS22540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EG343_RS22545	COG1132	(ABC) transporter
EG343_RS22560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EG343_RS22565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG343_RS22575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS22575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG343_RS22595	COG1566	PFAM secretion protein HlyD family protein
EG343_RS22610	COG1446	asparaginase
EG343_RS22620	COG3142	Participates in the control of copper homeostasis
EG343_RS22630	COG3250	beta-galactosidase activity
EG343_RS22635	COG0679	Auxin Efflux Carrier
EG343_RS22645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EG343_RS22655	COG0308	aminopeptidase N
EG343_RS22665	COG0156	8-amino-7-oxononanoate synthase activity
EG343_RS22670	COG1981	membrane
EG343_RS22700	COG0823	Involved in the tonB-independent uptake of proteins
EG343_RS22725	COG1959	2 iron, 2 sulfur cluster binding
EG343_RS22765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EG343_RS22770	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EG343_RS22775	COG2226	methyltransferase
EG343_RS22780	COG3720	iron ion transport
EG343_RS22790	COG0242	peptide deformylase activity
EG343_RS22800	COG1764	response to oxidative stress
EG343_RS22805	COG1846	Transcriptional regulator
EG343_RS22810	COG0778	Nitroreductase
EG343_RS22815	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS22830	COG0321	lipoyl(octanoyl) transferase activity
EG343_RS22835	COG0159	tryptophan synthase activity
EG343_RS22840	COG0133	tryptophan synthase activity
EG343_RS22855	COG0135	phosphoribosylanthranilate isomerase activity
EG343_RS22860	COG0134	indole-3-glycerol-phosphate synthase activity
EG343_RS22865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EG343_RS22870	COG0512	Glutamine amidotransferase of anthranilate synthase
EG343_RS22875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EG343_RS22900	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EG343_RS22905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EG343_RS22920	COG1271	oxidase subunit
EG343_RS22925	COG0187	DNA topoisomerase II activity
EG343_RS22960	COG1301	dicarboxylic acid transport
EG343_RS22965	COG0405	Gamma-glutamyltransferase
EG343_RS22970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EG343_RS22985	COG1408	metallophosphoesterase
EG343_RS22990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG343_RS23000	COG2226	methyltransferase
EG343_RS23020	COG1418	mRNA catabolic process
EG343_RS23025	COG0477	Major facilitator Superfamily
EG343_RS23040	COG2855	membrane
EG343_RS23050	COG0038	chloride channel
EG343_RS23060	COG1607	acyl-coa hydrolase
EG343_RS23080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EG343_RS23090	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EG343_RS23100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG343_RS23105	COG1970	mechanosensitive ion channel activity
EG343_RS23110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EG343_RS23115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EG343_RS23125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EG343_RS23145	COG0077	Prephenate dehydratase
EG343_RS23155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EG343_RS23160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EG343_RS23170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EG343_RS23220	COG2375	cellular response to nickel ion
EG343_RS23235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EG343_RS23235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EG343_RS23240	COG4206	TonB-dependent receptor
EG343_RS23240	COG1629	transport
EG343_RS23245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EG343_RS23255	COG1082	Xylose isomerase domain protein TIM barrel
EG343_RS23265	COG0641	radical SAM
EG343_RS23290	COG0366	Alpha amylase catalytic
EG343_RS23315	COG1741	Belongs to the pirin family
EG343_RS23325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EG343_RS23335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EG343_RS23345	COG0151	Belongs to the GarS family
EG343_RS23350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EG343_RS23350	COG0519	Catalyzes the synthesis of GMP from XMP
EG343_RS23355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EG343_RS23355	COG3153	acetyltransferase
EG343_RS23370	COG0513	Belongs to the DEAD box helicase family
EG343_RS23385	COG1979	alcohol dehydrogenase
EG343_RS23405	COG0242	peptide deformylase activity
EG343_RS23430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EG343_RS23435	COG4106	trans-aconitate 2-methyltransferase activity
EG343_RS23450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EG343_RS23455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EG343_RS23470	COG0531	amino acid
EG343_RS23480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EG343_RS23490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EG343_RS23490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EG343_RS23500	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EG343_RS23510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EG343_RS23515	COG0671	phosphoesterase, PA-phosphatase related
EG343_RS23530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EG343_RS23535	COG1295	ribonuclease BN
EG343_RS23540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EG343_RS23545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EG343_RS23555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EG343_RS23565	COG0745	RESPONSE REGULATOR receiver
EG343_RS23570	COG5002	protein histidine kinase activity
EG343_RS23610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EG343_RS23615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EG343_RS23625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EG343_RS23630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EG343_RS23635	COG0165	Argininosuccinate lyase
EG343_RS23640	COG1522	sequence-specific DNA binding
EG343_RS23645	COG0540	Belongs to the ATCase OTCase family
EG343_RS23700	COG2819	hydrolase of the alpha beta superfamily
EG343_RS23730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EG343_RS23730	COG2169	Transcriptional regulator
EG343_RS23780	COG1011	Hydrolase
EG343_RS23800	COG0492	ferredoxin-NADP+ reductase activity
EG343_RS23845	COG3685	Protein conserved in bacteria
EG343_RS23855	COG3813	Protein conserved in bacteria
EG343_RS23955	COG3279	Response regulator of the LytR AlgR family
EG343_RS23960	COG0784	Response regulator, receiver
EG343_RS23960	COG5002	protein histidine kinase activity
EG343_RS23960	COG2205	protein histidine kinase activity
EG343_RS23990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG343_RS24020	COG1028	Short-chain dehydrogenase reductase Sdr
EG343_RS24040	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EG343_RS24060	COG1959	2 iron, 2 sulfur cluster binding
EG343_RS24075	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS24075	COG4977	sequence-specific DNA binding
EG343_RS24095	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS24095	COG4977	sequence-specific DNA binding
EG343_RS24105	COG1619	proteins homologs of microcin C7 resistance protein MccF
EG343_RS24125	COG0463	Glycosyl transferase, family 2
EG343_RS24125	COG0457	Tetratricopeptide repeat
EG343_RS24140	COG4753	response regulator
EG343_RS24140	COG2207	Transcriptional regulator
EG343_RS24205	COG1120	ATPase activity
EG343_RS24210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EG343_RS24225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EG343_RS24255	COG2226	methyltransferase
EG343_RS24275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EG343_RS24285	COG0492	ferredoxin-NADP+ reductase activity
EG343_RS24290	COG0431	NADPH-dependent FMN reductase
EG343_RS24300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EG343_RS24310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EG343_RS24315	COG1595	DNA-templated transcription, initiation
EG343_RS24325	COG4771	TonB-dependent receptor
EG343_RS24325	COG1629	transport
EG343_RS24400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EG343_RS24445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EG343_RS24450	COG1129	ABC transporter
EG343_RS24455	COG2814	Major facilitator Superfamily
EG343_RS24460	COG1733	regulation of RNA biosynthetic process
EG343_RS24480	COG3118	belongs to the thioredoxin family
EG343_RS24605	COG4977	sequence-specific DNA binding
EG343_RS24625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG343_RS24640	COG0657	acetylesterase activity
EG343_RS24645	COG2072	flavoprotein involved in K transport
EG343_RS24685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EG343_RS24690	COG0582	viral genome integration into host DNA
EG343_RS24740	COG1629	transport
EG343_RS24740	COG4206	TonB-dependent receptor
EG343_RS24830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EG343_RS24835	COG0778	Nitroreductase
EG343_RS24840	COG1733	regulation of RNA biosynthetic process
EG343_RS24845	COG3214	Protein conserved in bacteria
EG343_RS24880	COG2837	iron assimilation
EG343_RS24895	COG0314	molybdopterin synthase activity
EG343_RS24900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EG343_RS24920	COG3781	membrane
EG343_RS24930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EG343_RS24935	COG0315	cyclic pyranopterin monophosphate synthase activity
EG343_RS24935	COG0746	molybdenum cofactor guanylyltransferase activity
EG343_RS24940	COG0315	cyclic pyranopterin monophosphate synthase activity
EG343_RS24945	COG0303	'Molybdopterin
EG343_RS24955	COG1917	Cupin 2, conserved barrel domain protein
EG343_RS24955	COG2207	Transcriptional regulator
EG343_RS24960	COG0384	phenazine biosynthesis protein PhzF
EG343_RS24990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EG343_RS25015	COG2814	Major facilitator Superfamily
EG343_RS25020	COG2197	response regulator
EG343_RS25025	COG2205	protein histidine kinase activity
EG343_RS25035	COG0156	8-amino-7-oxononanoate synthase activity
EG343_RS25045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EG343_RS25055	COG1605	Chorismate mutase
EG343_RS25055	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EG343_RS25060	COG1162	GTPase activity
EG343_RS25065	COG0105	UTP biosynthetic process
EG343_RS25080	COG3220	belongs to the UPF0276 family
EG343_RS25090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EG343_RS25095	COG1363	Peptidase, m42
EG343_RS25110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EG343_RS25110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EG343_RS25125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EG343_RS25175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG343_RS25180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EG343_RS25185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EG343_RS25215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG343_RS25220	COG0450	alkyl hydroperoxide reductase
EG343_RS25230	COG0436	Aminotransferase
EG343_RS25235	COG0357	Ribosomal RNA small subunit methyltransferase G
EG343_RS25275	COG4771	TonB-dependent receptor
EG343_RS25285	COG1960	acyl-CoA dehydrogenase activity