locus-tag	class	description
HUJ41_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUJ41_RS00010	COG0592	DNA-directed DNA polymerase activity
HUJ41_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUJ41_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUJ41_RS00025	COG0187	DNA topoisomerase II activity
HUJ41_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUJ41_RS00050	COG2076	Multidrug Resistance protein
HUJ41_RS00075	COG3764	Sortase (surface protein transpeptidase)
HUJ41_RS00090	COG0515	serine threonine protein kinase
HUJ41_RS00095	COG0515	serine threonine protein kinase
HUJ41_RS00100	COG0768	penicillin binding
HUJ41_RS00115	COG1716	ATPase activity
HUJ41_RS00120	COG1716	ATPase activity
HUJ41_RS00180	COG1755	Isoprenylcysteine carboxyl methyltransferase
HUJ41_RS00200	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUJ41_RS00205	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS00210	COG0738	Major facilitator superfamily
HUJ41_RS00215	COG3237	CsbD-like
HUJ41_RS00220	COG0534	Mate efflux family protein
HUJ41_RS00225	COG3590	peptidase
HUJ41_RS00255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUJ41_RS00260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUJ41_RS00280	COG0181	hydroxymethylbilane synthase activity
HUJ41_RS00285	COG0113	porphobilinogen synthase activity
HUJ41_RS00290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUJ41_RS00300	COG1120	ATPase activity
HUJ41_RS00305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUJ41_RS00310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUJ41_RS00345	COG0604	alcohol dehydrogenase
HUJ41_RS00390	COG1012	belongs to the aldehyde dehydrogenase family
HUJ41_RS00395	COG1725	Transcriptional regulator
HUJ41_RS00430	COG1834	amidinotransferase
HUJ41_RS00435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUJ41_RS00440	COG1840	ABC-type Fe3 transport system, periplasmic component
HUJ41_RS00450	COG3842	ATPase activity
HUJ41_RS00470	COG1960	acyl-CoA dehydrogenase activity
HUJ41_RS00475	COG2267	carboxylic ester hydrolase activity
HUJ41_RS00485	COG2755	lipolytic protein G-D-S-L family
HUJ41_RS00485	COG0657	acetylesterase activity
HUJ41_RS00525	COG1070	Carbohydrate kinase
HUJ41_RS00555	COG1846	Transcriptional regulator
HUJ41_RS00560	COG2267	carboxylic ester hydrolase activity
HUJ41_RS00570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUJ41_RS00580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUJ41_RS00585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUJ41_RS00630	COG0395	ABC-type sugar transport system, permease component
HUJ41_RS00645	COG1876	peptidase activity
HUJ41_RS00670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUJ41_RS00675	COG0561	phosphatase activity
HUJ41_RS00685	COG1316	TRANSCRIPTIONal
HUJ41_RS00700	COG5002	protein histidine kinase activity
HUJ41_RS00710	COG0604	alcohol dehydrogenase
HUJ41_RS00710	COG3321	synthase
HUJ41_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS00730	COG2313	pseudouridylate synthase activity
HUJ41_RS00745	COG5006	permease, DMT superfamily
HUJ41_RS00750	COG0415	Belongs to the DNA photolyase family
HUJ41_RS00765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUJ41_RS00775	COG1121	(ABC) transporter
HUJ41_RS00780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUJ41_RS00790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUJ41_RS00795	COG0590	tRNA wobble adenosine to inosine editing
HUJ41_RS00825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUJ41_RS00875	COG1201	RNA secondary structure unwinding
HUJ41_RS00895	COG0513	Belongs to the DEAD box helicase family
HUJ41_RS00940	COG0085	RNA polymerase activity
HUJ41_RS00945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUJ41_RS00950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUJ41_RS01010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUJ41_RS01015	COG0049	tRNA binding
HUJ41_RS01020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUJ41_RS01025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUJ41_RS01035	COG0051	transcription antitermination factor activity, RNA binding
HUJ41_RS01040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUJ41_RS01045	COG0088	Forms part of the polypeptide exit tunnel
HUJ41_RS01050	COG0089	rRNA binding
HUJ41_RS01055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUJ41_RS01060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUJ41_RS01065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUJ41_RS01070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUJ41_RS01075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUJ41_RS01080	COG0255	Belongs to the universal ribosomal protein uL29 family
HUJ41_RS01085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUJ41_RS01090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUJ41_RS01095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUJ41_RS01100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUJ41_RS01105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUJ41_RS01110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUJ41_RS01115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUJ41_RS01120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUJ41_RS01125	COG1841	ribosomal large subunit assembly
HUJ41_RS01130	COG0200	Binds to the 23S rRNA
HUJ41_RS01140	COG0563	adenylate kinase activity
HUJ41_RS01145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUJ41_RS01150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUJ41_RS01155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUJ41_RS01160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUJ41_RS01165	COG0202	RNA polymerase activity
HUJ41_RS01170	COG0203	ribosomal protein L17
HUJ41_RS01185	COG0101	tRNA pseudouridine synthase activity
HUJ41_RS01190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUJ41_RS01195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUJ41_RS01200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUJ41_RS01210	COG1072	(Pantothenic acid kinase))
HUJ41_RS01215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUJ41_RS01220	COG0736	holo-[acyl-carrier-protein] synthase activity
HUJ41_RS01225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUJ41_RS01230	COG0802	atpase or kinase
HUJ41_RS01245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUJ41_RS01265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUJ41_RS01315	COG0673	inositol 2-dehydrogenase activity
HUJ41_RS01320	COG0516	GMP reductase activity
HUJ41_RS01325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUJ41_RS01340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUJ41_RS01340	COG0519	Catalyzes the synthesis of GMP from XMP
HUJ41_RS01370	COG1366	Belongs to the anti-sigma-factor antagonist family
HUJ41_RS01380	COG0045	succinate-CoA ligase (ADP-forming) activity
HUJ41_RS01415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUJ41_RS01430	COG0138	bifunctional purine biosynthesis protein purh
HUJ41_RS01435	COG1834	amidinotransferase
HUJ41_RS01445	COG1132	(ABC) transporter
HUJ41_RS01455	COG3639	organic phosphonate transmembrane transporter activity
HUJ41_RS01460	COG3639	organic phosphonate transmembrane transporter activity
HUJ41_RS01465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUJ41_RS01505	COG2217	Heavy metal translocating P-type atpase
HUJ41_RS01530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUJ41_RS01540	COG2814	Major facilitator Superfamily
HUJ41_RS01545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUJ41_RS01550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUJ41_RS01555	COG0488	(ABC) transporter
HUJ41_RS01565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUJ41_RS01595	COG1435	thymidine kinase activity
HUJ41_RS01605	COG1408	metallophosphoesterase
HUJ41_RS01610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUJ41_RS01625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUJ41_RS01655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUJ41_RS01655	COG1754	DNA topoisomerase type I activity
HUJ41_RS01660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUJ41_RS01685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUJ41_RS01725	COG1470	cell adhesion involved in biofilm formation
HUJ41_RS01730	COG0459	protein refolding
HUJ41_RS01750	COG5000	phosphorelay sensor kinase activity
HUJ41_RS01750	COG5002	protein histidine kinase activity
HUJ41_RS01755	COG0745	RESPONSE REGULATOR receiver
HUJ41_RS01770	COG1061	Type III restriction enzyme res subunit
HUJ41_RS01785	COG1278	Cold shock
HUJ41_RS01805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUJ41_RS01815	COG0791	NLP P60 protein
HUJ41_RS01815	COG3883	PFAM NLP P60 protein
HUJ41_RS01840	COG3795	YCII-related domain
HUJ41_RS01865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUJ41_RS01875	COG0789	Transcriptional regulator
HUJ41_RS01885	COG1937	Protein conserved in bacteria
HUJ41_RS01965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUJ41_RS01970	COG1695	Transcriptional regulator
HUJ41_RS01975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUJ41_RS01980	COG1472	Belongs to the glycosyl hydrolase 3 family
HUJ41_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS02030	COG3842	ATPase activity
HUJ41_RS02035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUJ41_RS02040	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUJ41_RS02045	COG1177	transmembrane transport
HUJ41_RS02050	COG2957	Belongs to the agmatine deiminase family
HUJ41_RS02055	COG0154	amidase activity
HUJ41_RS02060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUJ41_RS02080	COG3386	PFAM SMP-30 Gluconolaconase
HUJ41_RS02100	COG2197	response regulator
HUJ41_RS02230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUJ41_RS02250	COG1794	racemase activity, acting on amino acids and derivatives
HUJ41_RS02285	COG0667	Aldo Keto reductase
HUJ41_RS02295	COG0431	NADPH-dependent FMN reductase
HUJ41_RS02310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUJ41_RS02315	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUJ41_RS02355	COG1643	Atp-dependent helicase
HUJ41_RS02370	COG1131	(ABC) transporter
HUJ41_RS02390	COG2079	MmgE PrpD family protein
HUJ41_RS02395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUJ41_RS02410	COG1331	Highly conserved protein containing a thioredoxin domain
HUJ41_RS02420	COG1832	CoA-binding protein
HUJ41_RS02435	COG2311	Membrane
HUJ41_RS02450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUJ41_RS02455	COG0084	hydrolase, TatD family'
HUJ41_RS02460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUJ41_RS02480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUJ41_RS02485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUJ41_RS02490	COG0183	Belongs to the thiolase family
HUJ41_RS02500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUJ41_RS02510	COG0488	(ABC) transporter
HUJ41_RS02515	COG0659	secondary active sulfate transmembrane transporter activity
HUJ41_RS02525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUJ41_RS02535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUJ41_RS02545	COG1846	Transcriptional regulator
HUJ41_RS02565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUJ41_RS02570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUJ41_RS02575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUJ41_RS02600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUJ41_RS02610	COG3265	gluconokinase activity
HUJ41_RS02615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUJ41_RS02620	COG0193	aminoacyl-tRNA hydrolase activity
HUJ41_RS02640	COG1131	(ABC) transporter
HUJ41_RS02650	COG0124	histidyl-tRNA synthetase
HUJ41_RS02655	COG0148	phosphopyruvate hydratase activity
HUJ41_RS02670	COG1404	Belongs to the peptidase S8 family
HUJ41_RS02675	COG1252	NADH dehydrogenase
HUJ41_RS02690	COG1704	LemA family
HUJ41_RS02695	COG0501	Belongs to the peptidase M48B family
HUJ41_RS02700	COG3214	Protein conserved in bacteria
HUJ41_RS02710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUJ41_RS02715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUJ41_RS02735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUJ41_RS02745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUJ41_RS02755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUJ41_RS02760	COG3002	Belongs to the UPF0753 family
HUJ41_RS02770	COG0114	fumarate hydratase activity
HUJ41_RS02775	COG0288	reversible hydration of carbon dioxide
HUJ41_RS02785	COG1722	exodeoxyribonuclease VII activity
HUJ41_RS02790	COG1570	exodeoxyribonuclease VII activity
HUJ41_RS02795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUJ41_RS02820	COG0191	fructose-bisphosphate aldolase activity
HUJ41_RS02830	COG0385	Bile acid
HUJ41_RS02835	COG0318	PFAM AMP-dependent synthetase and ligase
HUJ41_RS02865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUJ41_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS02875	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS02880	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS02890	COG0535	radical SAM domain protein
HUJ41_RS02925	COG2409	Drug exporters of the RND superfamily
HUJ41_RS02935	COG2801	Transposase and inactivated derivatives
HUJ41_RS02945	COG1322	Protein conserved in bacteria
HUJ41_RS02975	COG0697	spore germination
HUJ41_RS02980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUJ41_RS03000	COG0012	GTP binding
HUJ41_RS03040	COG0530	calcium, potassium:sodium antiporter activity
HUJ41_RS03070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUJ41_RS03075	COG0509	glycine decarboxylation via glycine cleavage system
HUJ41_RS03080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUJ41_RS03080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUJ41_RS03090	COG0747	negative chemotaxis
HUJ41_RS03100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUJ41_RS03120	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUJ41_RS03130	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUJ41_RS03130	COG2247	cell wall binding repeat
HUJ41_RS03135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUJ41_RS03195	COG3971	2-oxopent-4-enoate hydratase activity
HUJ41_RS03200	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HUJ41_RS03225	COG1116	anion transmembrane transporter activity
HUJ41_RS03225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUJ41_RS03230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUJ41_RS03315	COG1937	Protein conserved in bacteria
HUJ41_RS03320	COG2217	Heavy metal translocating P-type atpase
HUJ41_RS03345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUJ41_RS03350	COG0066	3-isopropylmalate dehydratase activity
HUJ41_RS03355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUJ41_RS03365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUJ41_RS03375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUJ41_RS03380	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUJ41_RS03425	COG2409	Drug exporters of the RND superfamily
HUJ41_RS03440	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUJ41_RS03450	COG2111	Na H antiporter
HUJ41_RS03450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUJ41_RS03470	COG2212	antiporter activity
HUJ41_RS03480	COG0129	dihydroxy-acid dehydratase activity
HUJ41_RS03490	COG0440	acetolactate synthase activity
HUJ41_RS03495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUJ41_RS03520	COG0315	cyclic pyranopterin monophosphate synthase activity
HUJ41_RS03570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUJ41_RS03595	COG0473	3-isopropylmalate dehydrogenase activity
HUJ41_RS03600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUJ41_RS03630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUJ41_RS03650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUJ41_RS03655	COG0583	DNA-binding transcription factor activity
HUJ41_RS03660	COG0489	protein tyrosine kinase activity
HUJ41_RS03660	COG2151	metal-sulfur cluster biosynthetic enzyme
HUJ41_RS03670	COG2239	Acts as a magnesium transporter
HUJ41_RS03685	COG0006	proline dipeptidase activity
HUJ41_RS03700	COG3328	transposase activity
HUJ41_RS03705	COG0613	PHP domain protein
HUJ41_RS03710	COG2814	Major facilitator Superfamily
HUJ41_RS03715	COG0513	Belongs to the DEAD box helicase family
HUJ41_RS03780	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUJ41_RS03790	COG3046	protein related to deoxyribodipyrimidine photolyase
HUJ41_RS03795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUJ41_RS03800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUJ41_RS03805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUJ41_RS03830	COG1620	l-lactate permease
HUJ41_RS03880	COG0477	Major facilitator Superfamily
HUJ41_RS03930	COG2116	formate transmembrane transporter activity
HUJ41_RS03970	COG0300	oxidoreductase activity
HUJ41_RS03975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUJ41_RS03980	COG2884	Cell division ATP-binding protein ftsE
HUJ41_RS03985	COG2177	Part of the ABC transporter FtsEX involved in
HUJ41_RS03990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUJ41_RS04030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUJ41_RS04040	COG4608	Belongs to the ABC transporter superfamily
HUJ41_RS04045	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUJ41_RS04050	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUJ41_RS04060	COG1960	acyl-CoA dehydrogenase activity
HUJ41_RS04065	COG1024	Enoyl-CoA hydratase
HUJ41_RS04080	COG2186	Transcriptional regulator
HUJ41_RS04085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUJ41_RS04115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUJ41_RS04125	COG2030	dehydratase
HUJ41_RS04135	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HUJ41_RS04140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUJ41_RS04160	COG1476	TRANSCRIPTIONal
HUJ41_RS04165	COG1063	alcohol dehydrogenase
HUJ41_RS04185	COG0483	inositol monophosphate 1-phosphatase activity
HUJ41_RS04190	COG1162	GTPase activity
HUJ41_RS04195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUJ41_RS04200	COG1595	DNA-templated transcription, initiation
HUJ41_RS04210	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUJ41_RS04210	COG0567	Dehydrogenase, E1 component
HUJ41_RS04220	COG1253	flavin adenine dinucleotide binding
HUJ41_RS04250	COG1403	HNH endonuclease
HUJ41_RS04280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUJ41_RS04290	COG3594	Acyltransferase
HUJ41_RS04300	COG2814	Major facilitator Superfamily
HUJ41_RS04305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUJ41_RS04335	COG1024	Enoyl-CoA hydratase
HUJ41_RS04350	COG1842	Phage shock protein A
HUJ41_RS04365	COG1595	DNA-templated transcription, initiation
HUJ41_RS04375	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUJ41_RS04385	COG0569	domain protein
HUJ41_RS04385	COG0189	ligase activity
HUJ41_RS04390	COG0189	ligase activity
HUJ41_RS04390	COG4067	protein conserved in archaea
HUJ41_RS04405	COG1620	l-lactate permease
HUJ41_RS04410	COG0018	arginyl-trna synthetase
HUJ41_RS04425	COG0460	homoserine dehydrogenase
HUJ41_RS04435	COG0083	homoserine kinase activity
HUJ41_RS04445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUJ41_RS04450	COG2890	protein-(glutamine-N5) methyltransferase activity
HUJ41_RS04465	COG0686	Belongs to the AlaDH PNT family
HUJ41_RS04490	COG0356	it plays a direct role in the translocation of protons across the membrane
HUJ41_RS04495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUJ41_RS04500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUJ41_RS04505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUJ41_RS04510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUJ41_RS04515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUJ41_RS04520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUJ41_RS04525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUJ41_RS04535	COG3022	response to hydroperoxide
HUJ41_RS04540	COG0519	Catalyzes the synthesis of GMP from XMP
HUJ41_RS04550	COG0667	Aldo Keto reductase
HUJ41_RS04560	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HUJ41_RS04565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUJ41_RS04570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUJ41_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
HUJ41_RS04590	COG0631	protein serine/threonine phosphatase activity
HUJ41_RS04605	COG0714	Associated with various cellular activities
HUJ41_RS04625	COG1674	ftsk spoiiie
HUJ41_RS04635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUJ41_RS04640	COG3842	ATPase activity
HUJ41_RS04670	COG0545	Peptidyl-prolyl cis-trans isomerase
HUJ41_RS04675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUJ41_RS04680	COG0750	zinc metalloprotease
HUJ41_RS04685	COG3415	Transposase
HUJ41_RS04685	COG2801	Transposase and inactivated derivatives
HUJ41_RS04695	COG0411	ABC transporter
HUJ41_RS04715	COG0318	PFAM AMP-dependent synthetase and ligase
HUJ41_RS04720	COG1309	transcriptional regulator
HUJ41_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS04735	COG0596	Alpha beta hydrolase
HUJ41_RS04740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUJ41_RS04745	COG0442	prolyl-tRNA aminoacylation
HUJ41_RS04755	COG1115	amino acid carrier protein
HUJ41_RS04770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUJ41_RS04775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUJ41_RS04790	COG1194	a g-specific adenine glycosylase
HUJ41_RS04795	COG0702	epimerase
HUJ41_RS04800	COG0584	glycerophosphoryl diester phosphodiesterase
HUJ41_RS04805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUJ41_RS04815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUJ41_RS04820	COG3281	Trehalose synthase
HUJ41_RS04850	COG0484	heat shock protein binding
HUJ41_RS05000	COG0501	Belongs to the peptidase M48B family
HUJ41_RS05010	COG0501	Belongs to the peptidase M48B family
HUJ41_RS05020	COG3657	addiction module killer protein
HUJ41_RS05025	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUJ41_RS05095	COG3744	PilT protein domain protein
HUJ41_RS05135	COG3842	ATPase activity
HUJ41_RS05140	COG0395	ABC-type sugar transport system, permease component
HUJ41_RS05160	COG1070	Carbohydrate kinase
HUJ41_RS05170	COG0434	BtpA family
HUJ41_RS05210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUJ41_RS05210	COG0512	Glutamine amidotransferase of anthranilate synthase
HUJ41_RS05215	COG0495	leucyl-tRNA aminoacylation
HUJ41_RS05235	COG0268	Binds directly to 16S ribosomal RNA
HUJ41_RS05240	COG0481	GTPase activity
HUJ41_RS05255	COG0196	riboflavin kinase activity
HUJ41_RS05270	COG2807	transmembrane transport
HUJ41_RS05285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUJ41_RS05290	COG1012	belongs to the aldehyde dehydrogenase family
HUJ41_RS05295	COG1012	belongs to the aldehyde dehydrogenase family
HUJ41_RS05305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUJ41_RS05310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUJ41_RS05325	COG2072	flavoprotein involved in K transport
HUJ41_RS05345	COG1420	regulation of RNA biosynthetic process
HUJ41_RS05350	COG0484	heat shock protein binding
HUJ41_RS05360	COG0537	adenosine 5'-monophosphoramidase activity
HUJ41_RS05370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUJ41_RS05380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUJ41_RS05385	COG2197	response regulator
HUJ41_RS05390	COG4585	Histidine kinase
HUJ41_RS05395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUJ41_RS05415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUJ41_RS05420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUJ41_RS05430	COG1104	cysteine desulfurase activity
HUJ41_RS05435	COG1381	Involved in DNA repair and RecF pathway recombination
HUJ41_RS05440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUJ41_RS05450	COG0423	glycine-tRNA ligase activity
HUJ41_RS05465	COG0442	prolyl-tRNA aminoacylation
HUJ41_RS05470	COG0673	inositol 2-dehydrogenase activity
HUJ41_RS05485	COG0358	DNA primase activity
HUJ41_RS05505	COG4585	Histidine kinase
HUJ41_RS05510	COG2197	response regulator
HUJ41_RS05525	COG0242	peptide deformylase activity
HUJ41_RS05535	COG0438	transferase activity, transferring glycosyl groups
HUJ41_RS05575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUJ41_RS05580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUJ41_RS05595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUJ41_RS05615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUJ41_RS05630	COG3328	transposase activity
HUJ41_RS05655	COG0464	growth
HUJ41_RS05680	COG0697	spore germination
HUJ41_RS05685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUJ41_RS05725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUJ41_RS05730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUJ41_RS05730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUJ41_RS05740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUJ41_RS05760	COG0174	glutamine synthetase
HUJ41_RS05765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUJ41_RS05770	COG0321	lipoyl(octanoyl) transferase activity
HUJ41_RS05790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUJ41_RS05795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUJ41_RS05800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUJ41_RS05810	COG2223	nitrite transmembrane transporter activity
HUJ41_RS05815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUJ41_RS05835	COG0187	DNA topoisomerase II activity
HUJ41_RS05840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUJ41_RS05865	COG0756	dUTP diphosphatase activity
HUJ41_RS05880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUJ41_RS05885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUJ41_RS05890	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUJ41_RS05890	COG1024	Enoyl-CoA hydratase
HUJ41_RS05895	COG0183	Belongs to the thiolase family
HUJ41_RS05935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUJ41_RS05970	COG1215	transferase activity, transferring glycosyl groups
HUJ41_RS05980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUJ41_RS05990	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUJ41_RS05995	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUJ41_RS06005	COG0217	transcriptional regulatory protein
HUJ41_RS06010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUJ41_RS06015	COG0632	four-way junction helicase activity
HUJ41_RS06020	COG2255	four-way junction helicase activity
HUJ41_RS06030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUJ41_RS06035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUJ41_RS06040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUJ41_RS06050	COG1196	nuclear chromosome segregation
HUJ41_RS06065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUJ41_RS06075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUJ41_RS06080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUJ41_RS06090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUJ41_RS06095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUJ41_RS06100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUJ41_RS06105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUJ41_RS06110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUJ41_RS06115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUJ41_RS06120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUJ41_RS06135	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUJ41_RS06140	COG3639	organic phosphonate transmembrane transporter activity
HUJ41_RS06145	COG3639	organic phosphonate transmembrane transporter activity
HUJ41_RS06155	COG1116	anion transmembrane transporter activity
HUJ41_RS06165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUJ41_RS06170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUJ41_RS06175	COG0540	Belongs to the ATCase OTCase family
HUJ41_RS06180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUJ41_RS06190	COG0505	Belongs to the CarA family
HUJ41_RS06195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUJ41_RS06205	COG0194	GDP metabolic process
HUJ41_RS06210	COG1758	RNA polymerase activity
HUJ41_RS06220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUJ41_RS06230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUJ41_RS06240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUJ41_RS06245	COG0545	Peptidyl-prolyl cis-trans isomerase
HUJ41_RS06250	COG0140	phosphoribosyl-ATP diphosphatase activity
HUJ41_RS06255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUJ41_RS06260	COG0107	imidazoleglycerol-phosphate synthase activity
HUJ41_RS06265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUJ41_RS06285	COG0134	indole-3-glycerol-phosphate synthase activity
HUJ41_RS06290	COG0133	tryptophan synthase activity
HUJ41_RS06295	COG0159	tryptophan synthase activity
HUJ41_RS06300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUJ41_RS06305	COG0070	glutamate synthase
HUJ41_RS06305	COG0069	glutamate synthase activity
HUJ41_RS06305	COG0067	glutamate synthase
HUJ41_RS06315	COG0469	pyruvate kinase activity
HUJ41_RS06335	COG2050	protein possibly involved in aromatic compounds catabolism
HUJ41_RS06350	COG0539	negative regulation of cytoplasmic translation
HUJ41_RS06360	COG0237	dephospho-CoA kinase activity
HUJ41_RS06365	COG0556	nucleotide-excision repair
HUJ41_RS06375	COG0322	excinuclease ABC activity
HUJ41_RS06380	COG1660	Displays ATPase and GTPase activities
HUJ41_RS06385	COG1481	regulation of sporulation
HUJ41_RS06390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUJ41_RS06395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUJ41_RS06400	COG0126	phosphoglycerate kinase activity
HUJ41_RS06405	COG0149	triose-phosphate isomerase activity
HUJ41_RS06410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUJ41_RS06420	COG0363	glucosamine-6-phosphate deaminase activity
HUJ41_RS06435	COG0166	Belongs to the GPI family
HUJ41_RS06440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUJ41_RS06450	COG0109	protoheme IX farnesyltransferase activity
HUJ41_RS06475	COG0396	ATPase activity
HUJ41_RS06480	COG2151	metal-sulfur cluster biosynthetic enzyme
HUJ41_RS06485	COG1268	BioY protein
HUJ41_RS06490	COG0488	(ABC) transporter
HUJ41_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
HUJ41_RS06515	COG0560	Phosphoserine phosphatase
HUJ41_RS06520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUJ41_RS06525	COG0297	glycogen (starch) synthase activity
HUJ41_RS06530	COG1119	ATPase activity
HUJ41_RS06535	COG0254	rRNA binding
HUJ41_RS06560	COG0442	prolyl-tRNA aminoacylation
HUJ41_RS06585	COG2755	lipolytic protein G-D-S-L family
HUJ41_RS06595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUJ41_RS06615	COG0587	DNA-directed DNA polymerase activity
HUJ41_RS06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUJ41_RS06670	COG1968	undecaprenyl-diphosphatase activity
HUJ41_RS06710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUJ41_RS06715	COG0805	protein transport
HUJ41_RS06730	COG0463	Glycosyl transferase, family 2
HUJ41_RS06785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUJ41_RS06820	COG3012	SEC-C Motif Domain Protein
HUJ41_RS06830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUJ41_RS06835	COG1845	cytochrome c oxidase, subunit III
HUJ41_RS06840	COG2010	Cytochrome c
HUJ41_RS06845	COG0723	plastoquinol--plastocyanin reductase activity
HUJ41_RS06850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUJ41_RS06870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUJ41_RS06875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUJ41_RS06885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUJ41_RS06895	COG0167	dihydroorotate dehydrogenase activity
HUJ41_RS06900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUJ41_RS06905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUJ41_RS06935	COG1799	cell septum assembly
HUJ41_RS06945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUJ41_RS06950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUJ41_RS06955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUJ41_RS06960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUJ41_RS06970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUJ41_RS06975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUJ41_RS06980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUJ41_RS06985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUJ41_RS06990	COG0768	penicillin binding
HUJ41_RS07000	COG0275	rRNA processing
HUJ41_RS07005	COG2001	Belongs to the MraZ family
HUJ41_RS07015	COG0142	geranyltranstransferase activity
HUJ41_RS07025	COG3942	CHAP domain
HUJ41_RS07025	COG1388	LysM domain
HUJ41_RS07030	COG2815	serine threonine protein kinase
HUJ41_RS07030	COG0515	serine threonine protein kinase
HUJ41_RS07035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUJ41_RS07045	COG1940	carbohydrate kinase activity
HUJ41_RS07050	COG1022	Amp-dependent synthetase and ligase
HUJ41_RS07055	COG0242	peptide deformylase activity
HUJ41_RS07065	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUJ41_RS07070	COG1192	Involved in chromosome partitioning
HUJ41_RS07085	COG1716	ATPase activity
HUJ41_RS07110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUJ41_RS07115	COG3387	PFAM Glycoside hydrolase 15-related
HUJ41_RS07125	COG0039	L-malate dehydrogenase activity
HUJ41_RS07135	COG0277	FAD linked oxidase domain protein
HUJ41_RS07145	COG1012	belongs to the aldehyde dehydrogenase family
HUJ41_RS07150	COG3537	Alpha-1,2-mannosidase
HUJ41_RS07160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUJ41_RS07175	COG2442	InterPro IPR007367
HUJ41_RS07185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUJ41_RS07210	COG1058	Belongs to the CinA family
HUJ41_RS07210	COG1546	Belongs to the CinA family
HUJ41_RS07225	COG0137	argininosuccinate synthase activity
HUJ41_RS07235	COG4175	Glycine betaine
HUJ41_RS07235	COG0517	IMP dehydrogenase activity
HUJ41_RS07265	COG1253	flavin adenine dinucleotide binding
HUJ41_RS07300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUJ41_RS07310	COG1305	Transglutaminase-like
HUJ41_RS07405	COG0210	DNA helicase
HUJ41_RS07430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUJ41_RS07445	COG0477	Major facilitator Superfamily
HUJ41_RS07465	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUJ41_RS07470	COG0494	nUDIX hydrolase
HUJ41_RS07500	COG1160	GTP binding
HUJ41_RS07505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUJ41_RS07520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUJ41_RS07525	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUJ41_RS07550	COG0504	CTP synthase activity
HUJ41_RS07560	COG2165	general secretion pathway protein
HUJ41_RS07570	COG0497	DNA recombination
HUJ41_RS07575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUJ41_RS07590	COG0647	UMP catabolic process
HUJ41_RS07615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUJ41_RS07625	COG2094	Belongs to the DNA glycosylase MPG family
HUJ41_RS07630	COG0165	Argininosuccinate lyase
HUJ41_RS07635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUJ41_RS07640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUJ41_RS07645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUJ41_RS07650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUJ41_RS07655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUJ41_RS07660	COG0072	phenylalanine-tRNA ligase activity
HUJ41_RS07660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUJ41_RS07665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUJ41_RS07670	COG0765	amino acid transport
HUJ41_RS07675	COG0765	amino acid transport
HUJ41_RS07680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUJ41_RS07685	COG1126	abc transporter atp-binding protein
HUJ41_RS07690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUJ41_RS07695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUJ41_RS07700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUJ41_RS07705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUJ41_RS07720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUJ41_RS07725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUJ41_RS07730	COG0131	Imidazoleglycerol-phosphate dehydratase
HUJ41_RS07735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUJ41_RS07745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUJ41_RS07750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUJ41_RS07755	COG2813	Specifically methylates the guanine in position
HUJ41_RS07760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUJ41_RS07765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUJ41_RS07770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUJ41_RS07795	COG2137	regulation of response to DNA damage stimulus
HUJ41_RS07800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUJ41_RS07810	COG1396	sequence-specific DNA binding
HUJ41_RS07815	COG1546	Belongs to the CinA family
HUJ41_RS07815	COG1058	Belongs to the CinA family
HUJ41_RS07825	COG1674	ftsk spoiiie
HUJ41_RS07840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUJ41_RS07845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUJ41_RS07855	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUJ41_RS07870	COG1764	response to oxidative stress
HUJ41_RS07875	COG1090	epimerase
HUJ41_RS07885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUJ41_RS07895	COG1937	Protein conserved in bacteria
HUJ41_RS07900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUJ41_RS07905	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUJ41_RS07925	COG0667	Aldo Keto reductase
HUJ41_RS07935	COG1309	transcriptional regulator
HUJ41_RS07940	COG1131	(ABC) transporter
HUJ41_RS07950	COG1185	polyribonucleotide nucleotidyltransferase activity
HUJ41_RS07980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUJ41_RS08065	COG0590	tRNA wobble adenosine to inosine editing
HUJ41_RS08070	COG4988	ABC transporter
HUJ41_RS08080	COG1294	oxidase, subunit
HUJ41_RS08085	COG1271	oxidase subunit
HUJ41_RS08095	COG1732	Glycine betaine
HUJ41_RS08100	COG1174	glycine betaine transport
HUJ41_RS08105	COG1174	glycine betaine transport
HUJ41_RS08110	COG0517	IMP dehydrogenase activity
HUJ41_RS08110	COG1125	glycine betaine transport
HUJ41_RS08130	COG5002	protein histidine kinase activity
HUJ41_RS08135	COG0745	RESPONSE REGULATOR receiver
HUJ41_RS08155	COG1472	Belongs to the glycosyl hydrolase 3 family
HUJ41_RS08180	COG0259	pyridoxamine-phosphate oxidase activity
HUJ41_RS08200	COG0395	ABC-type sugar transport system, permease component
HUJ41_RS08205	COG1175	transmembrane transport
HUJ41_RS08225	COG2188	Transcriptional regulator
HUJ41_RS08245	COG0799	negative regulation of ribosome biogenesis
HUJ41_RS08255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUJ41_RS08265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUJ41_RS08270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUJ41_RS08275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUJ41_RS08280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUJ41_RS08285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUJ41_RS08310	COG0701	Predicted permease
HUJ41_RS08315	COG1530	ribonuclease E activity
HUJ41_RS08335	COG0285	dihydrofolate synthase activity
HUJ41_RS08340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUJ41_RS08355	COG0477	Major facilitator Superfamily
HUJ41_RS08370	COG0525	valine-tRNA ligase activity
HUJ41_RS08375	COG0531	amino acid
HUJ41_RS08400	COG0339	signal peptide processing
HUJ41_RS08405	COG4552	Acetyltransferase involved in intracellular survival and related
HUJ41_RS08415	COG3135	benzoate transporter
HUJ41_RS08420	COG1501	Belongs to the glycosyl hydrolase 31 family
HUJ41_RS08425	COG3387	PFAM Glycoside hydrolase 15-related
HUJ41_RS08435	COG0395	ABC-type sugar transport system, permease component
HUJ41_RS08440	COG1175	transmembrane transport
HUJ41_RS08445	COG1940	carbohydrate kinase activity
HUJ41_RS08445	COG1846	Transcriptional regulator
HUJ41_RS08455	COG1403	HNH endonuclease
HUJ41_RS08460	COG0259	pyridoxamine-phosphate oxidase activity
HUJ41_RS08465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUJ41_RS08485	COG0740	serine-type endopeptidase activity
HUJ41_RS08490	COG0740	serine-type endopeptidase activity
HUJ41_RS08495	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUJ41_RS08550	COG0698	ribose 5-phosphate isomerase
HUJ41_RS08565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUJ41_RS08580	COG0668	transmembrane transport
HUJ41_RS08600	COG1946	Acyl-CoA thioesterase
HUJ41_RS08630	COG2204	response regulator
HUJ41_RS08645	COG0629	single-stranded DNA binding
HUJ41_RS08660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUJ41_RS08665	COG0667	Aldo Keto reductase
HUJ41_RS08685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUJ41_RS08700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUJ41_RS08710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUJ41_RS08735	COG1122	ATPase activity
HUJ41_RS08740	COG4721	ABC-type cobalt transport system, permease component
HUJ41_RS08745	COG0861	Integral membrane protein TerC family
HUJ41_RS08765	COG0463	Glycosyl transferase, family 2
HUJ41_RS08780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUJ41_RS08790	COG4134	Bacterial extracellular solute-binding protein
HUJ41_RS08805	COG3842	ATPase activity
HUJ41_RS08815	COG4942	peptidase
HUJ41_RS08835	COG1278	Cold shock
HUJ41_RS08850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUJ41_RS08855	COG1131	(ABC) transporter
HUJ41_RS08865	COG2890	protein-(glutamine-N5) methyltransferase activity
HUJ41_RS08930	COG2149	membrane
HUJ41_RS08935	COG3119	arylsulfatase activity
HUJ41_RS08960	COG1940	carbohydrate kinase activity
HUJ41_RS08985	COG0693	protein deglycase activity
HUJ41_RS09055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUJ41_RS09060	COG0154	amidase activity
HUJ41_RS09065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUJ41_RS09080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUJ41_RS09085	COG0482	sulfurtransferase activity
HUJ41_RS09105	COG4608	Belongs to the ABC transporter superfamily
HUJ41_RS09110	COG0444	Belongs to the ABC transporter superfamily
HUJ41_RS09120	COG0601	transmembrane transport
HUJ41_RS09140	COG0058	SHG alpha-glucan phosphorylase activity
HUJ41_RS09145	COG0366	Alpha amylase catalytic
HUJ41_RS09150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUJ41_RS09200	COG0233	cytoplasmic translational termination
HUJ41_RS09210	COG0528	UMP kinase activity
HUJ41_RS09225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUJ41_RS09230	COG0052	Belongs to the universal ribosomal protein uS2 family
HUJ41_RS09240	COG4974	Belongs to the 'phage' integrase family
HUJ41_RS09245	COG2409	Drug exporters of the RND superfamily
HUJ41_RS09305	COG3328	transposase activity
HUJ41_RS09330	COG2197	response regulator
HUJ41_RS09370	COG0583	DNA-binding transcription factor activity
HUJ41_RS09380	COG4829	muconolactone delta-isomerase
HUJ41_RS09385	COG3485	protocatechuate 3,4-dioxygenase
HUJ41_RS09390	COG2267	carboxylic ester hydrolase activity
HUJ41_RS09395	COG1607	acyl-coa hydrolase
HUJ41_RS09400	COG1414	Transcriptional regulator
HUJ41_RS09405	COG0183	Belongs to the thiolase family
HUJ41_RS09410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUJ41_RS09435	COG0792	nuclease activity
HUJ41_RS09450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUJ41_RS09460	COG0335	large ribosomal subunit rRNA binding
HUJ41_RS09465	COG1309	transcriptional regulator
HUJ41_RS09480	COG0336	Belongs to the RNA methyltransferase TrmD family
HUJ41_RS09485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUJ41_RS09490	COG1837	Belongs to the UPF0109 family
HUJ41_RS09495	COG0228	four-way junction DNA binding
HUJ41_RS09535	COG1131	(ABC) transporter
HUJ41_RS09565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUJ41_RS09570	COG1216	Glycosyl transferase, family 2
HUJ41_RS09570	COG0463	Glycosyl transferase, family 2
HUJ41_RS09575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUJ41_RS09600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUJ41_RS09610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUJ41_RS09640	COG1615	UPF0182 protein
HUJ41_RS09645	COG1196	nuclear chromosome segregation
HUJ41_RS09660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUJ41_RS09665	COG0571	ribonuclease III activity
HUJ41_RS09670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUJ41_RS09695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUJ41_RS09695	COG1116	anion transmembrane transporter activity
HUJ41_RS09700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUJ41_RS09710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUJ41_RS09720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUJ41_RS09725	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUJ41_RS09735	COG1920	GTP binding
HUJ41_RS09745	COG0714	Associated with various cellular activities
HUJ41_RS09755	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUJ41_RS09755	COG0778	Nitroreductase
HUJ41_RS09775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUJ41_RS09780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUJ41_RS09795	COG0742	ribosomal rna small subunit methyltransferase
HUJ41_RS09830	COG0653	protein targeting
HUJ41_RS09835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUJ41_RS09840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUJ41_RS09845	COG5401	PFAM Sporulation and spore germination
HUJ41_RS09850	COG5002	protein histidine kinase activity
HUJ41_RS09855	COG0745	RESPONSE REGULATOR receiver
HUJ41_RS09875	COG0714	Associated with various cellular activities
HUJ41_RS09910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUJ41_RS09915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUJ41_RS09965	COG1960	acyl-CoA dehydrogenase activity
HUJ41_RS09985	COG3550	peptidyl-serine autophosphorylation
HUJ41_RS10025	COG1132	(ABC) transporter
HUJ41_RS10030	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUJ41_RS10030	COG2247	cell wall binding repeat
HUJ41_RS10100	COG1215	transferase activity, transferring glycosyl groups
HUJ41_RS10110	COG0297	glycogen (starch) synthase activity
HUJ41_RS10120	COG0463	Glycosyl transferase, family 2
HUJ41_RS10155	COG1088	dTDP-glucose 4,6-dehydratase activity
HUJ41_RS10175	COG0438	transferase activity, transferring glycosyl groups
HUJ41_RS10180	COG0438	transferase activity, transferring glycosyl groups
HUJ41_RS10185	COG1316	TRANSCRIPTIONal
HUJ41_RS10210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUJ41_RS10245	COG1122	ATPase activity
HUJ41_RS10255	COG2755	lipolytic protein G-D-S-L family
HUJ41_RS10255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUJ41_RS10260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUJ41_RS10285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUJ41_RS10290	COG0424	maF-like protein
HUJ41_RS10295	COG4770	biotin carboxylase activity
HUJ41_RS10310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUJ41_RS10335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUJ41_RS10345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUJ41_RS10350	COG1957	nucleoside hydrolase
HUJ41_RS10390	COG0438	transferase activity, transferring glycosyl groups
HUJ41_RS10395	COG2009	succinate dehydrogenase
HUJ41_RS10405	COG1053	succinate dehydrogenase
HUJ41_RS10410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUJ41_RS10425	COG0180	Tryptophanyl-tRNA synthetase
HUJ41_RS10445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUJ41_RS10450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUJ41_RS10475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUJ41_RS10475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUJ41_RS10480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUJ41_RS10500	COG1131	(ABC) transporter
HUJ41_RS10505	COG1132	(ABC) transporter
HUJ41_RS10510	COG1335	isochorismatase
HUJ41_RS10515	COG2027	D-alanyl-D-alanine carboxypeptidase
HUJ41_RS10540	COG3842	ATPase activity
HUJ41_RS10550	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUJ41_RS10565	COG1802	Transcriptional regulator
HUJ41_RS10600	COG0215	cysteine-tRNA ligase activity
HUJ41_RS10605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUJ41_RS10605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUJ41_RS10625	COG5002	protein histidine kinase activity
HUJ41_RS10640	COG0588	phosphoglycerate mutase activity
HUJ41_RS10660	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HUJ41_RS10670	COG0745	RESPONSE REGULATOR receiver
HUJ41_RS10675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUJ41_RS10700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUJ41_RS10705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUJ41_RS10710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUJ41_RS10765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUJ41_RS10770	COG2059	Chromate
HUJ41_RS10790	COG1175	transmembrane transport
HUJ41_RS10800	COG3119	arylsulfatase activity
HUJ41_RS10805	COG3119	arylsulfatase activity
HUJ41_RS10810	COG0583	DNA-binding transcription factor activity
HUJ41_RS10820	COG1349	DNA-binding transcription factor activity
HUJ41_RS10830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUJ41_RS10835	COG0579	oxidoreductase
HUJ41_RS10840	COG0730	response to heat
HUJ41_RS10905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUJ41_RS10915	COG0702	epimerase
HUJ41_RS10920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUJ41_RS10930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUJ41_RS10930	COG0723	plastoquinol--plastocyanin reductase activity
HUJ41_RS10950	COG3655	Transcriptional regulator
HUJ41_RS10960	COG0433	COG0433 Predicted ATPase
HUJ41_RS10965	COG1929	Belongs to the glycerate kinase type-1 family
HUJ41_RS10970	COG0277	FAD linked oxidase domain protein
HUJ41_RS10980	COG0671	phosphoesterase, PA-phosphatase related
HUJ41_RS10985	COG2814	Major facilitator Superfamily
HUJ41_RS11020	COG1132	(ABC) transporter
HUJ41_RS11025	COG0395	ABC-type sugar transport system, permease component
HUJ41_RS11030	COG1175	transmembrane transport
HUJ41_RS11035	COG1653	transport
HUJ41_RS11045	COG0222	ribosome binding
HUJ41_RS11050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUJ41_RS11055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUJ41_RS11060	COG2205	protein histidine kinase activity
HUJ41_RS11065	COG0745	RESPONSE REGULATOR receiver
HUJ41_RS11070	COG3321	synthase
HUJ41_RS11070	COG4221	oxidoreductase activity
HUJ41_RS11070	COG0604	alcohol dehydrogenase
HUJ41_RS11070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUJ41_RS11080	COG0081	regulation of translation
HUJ41_RS11085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUJ41_RS11105	COG0436	Aminotransferase
HUJ41_RS11135	COG2197	response regulator
HUJ41_RS11140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUJ41_RS11150	COG2030	dehydratase
HUJ41_RS11175	COG0366	Alpha amylase catalytic
HUJ41_RS11180	COG0739	heme binding
HUJ41_RS11200	COG1666	GTP binding
HUJ41_RS11205	COG2814	Major facilitator Superfamily
HUJ41_RS11210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUJ41_RS11230	COG2226	methyltransferase
HUJ41_RS11240	COG2326	polyphosphate kinase activity
HUJ41_RS11245	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUJ41_RS11270	COG0745	RESPONSE REGULATOR receiver
HUJ41_RS11275	COG5002	protein histidine kinase activity
HUJ41_RS11295	COG4948	Mandelate Racemase Muconate Lactonizing
HUJ41_RS11305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUJ41_RS11370	COG3336	cytochrome c oxidase
HUJ41_RS11395	COG0785	Cytochrome C biogenesis protein
HUJ41_RS11400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUJ41_RS11405	COG0406	alpha-ribazole phosphatase activity
HUJ41_RS11410	COG0017	Asparaginyl-tRNA synthetase
HUJ41_RS11435	COG0346	lactoylglutathione lyase activity
HUJ41_RS11455	COG0149	triose-phosphate isomerase activity
HUJ41_RS11460	COG0698	ribose 5-phosphate isomerase
HUJ41_RS11465	COG2376	Dihydroxyacetone kinase
HUJ41_RS11470	COG1879	ABC-type sugar transport system periplasmic component
HUJ41_RS11475	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUJ41_RS11480	COG1129	ABC transporter
HUJ41_RS11505	COG0386	Belongs to the glutathione peroxidase family
HUJ41_RS11515	COG1295	ribonuclease BN
HUJ41_RS11545	COG3328	transposase activity
HUJ41_RS11580	COG2059	Chromate
HUJ41_RS11585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUJ41_RS11600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUJ41_RS11620	COG3655	Transcriptional regulator
HUJ41_RS11645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUJ41_RS11650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUJ41_RS11675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUJ41_RS11680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUJ41_RS11690	COG0302	gtp cyclohydrolase
HUJ41_RS11695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUJ41_RS11705	COG0037	tRNA processing
HUJ41_RS11710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUJ41_RS11715	COG0791	NLP P60 protein
HUJ41_RS11715	COG3883	PFAM NLP P60 protein
HUJ41_RS11760	COG0494	nUDIX hydrolase
HUJ41_RS11805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUJ41_RS11810	COG0514	ATP-dependent DNA helicase (RecQ)
HUJ41_RS11815	COG1045	serine acetyltransferase
HUJ41_RS11830	COG0513	Belongs to the DEAD box helicase family
HUJ41_RS11845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUJ41_RS11865	COG0789	Transcriptional regulator
HUJ41_RS11885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUJ41_RS11920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUJ41_RS11940	COG0151	Belongs to the GarS family
HUJ41_RS11945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUJ41_RS11950	COG2514	catechol 2,3-dioxygenase activity
HUJ41_RS11965	COG1072	(Pantothenic acid kinase))
HUJ41_RS11975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUJ41_RS11980	COG0047	phosphoribosylformylglycinamidine synthase activity
HUJ41_RS12010	COG1175	transmembrane transport
HUJ41_RS12030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUJ41_RS12035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUJ41_RS12045	COG0287	Prephenate dehydrogenase
HUJ41_RS12045	COG1605	Chorismate mutase
HUJ41_RS12055	COG1215	transferase activity, transferring glycosyl groups
HUJ41_RS12070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUJ41_RS12075	COG1309	transcriptional regulator
HUJ41_RS12095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUJ41_RS12105	COG1403	HNH endonuclease
HUJ41_RS12110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HUJ41_RS12125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUJ41_RS12165	COG2197	response regulator
HUJ41_RS12170	COG4152	abc transporter atp-binding protein
HUJ41_RS12195	COG0542	response to heat
HUJ41_RS12210	COG0789	Transcriptional regulator
HUJ41_RS12215	COG0484	heat shock protein binding
HUJ41_RS12220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUJ41_RS12225	COG0443	Heat shock 70 kDa protein
HUJ41_RS12235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUJ41_RS12240	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUJ41_RS12295	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUJ41_RS12300	COG5002	protein histidine kinase activity
HUJ41_RS12305	COG0745	RESPONSE REGULATOR receiver
HUJ41_RS12310	COG0717	Belongs to the dCTP deaminase family
HUJ41_RS12330	COG3328	transposase activity
HUJ41_RS12380	COG3328	transposase activity
HUJ41_RS12405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUJ41_RS12415	COG3336	cytochrome c oxidase
HUJ41_RS12420	COG0776	regulation of translation
HUJ41_RS12425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUJ41_RS12430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUJ41_RS12435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUJ41_RS12440	COG0735	belongs to the Fur family
HUJ41_RS12450	COG1121	(ABC) transporter
HUJ41_RS12455	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUJ41_RS12465	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUJ41_RS12470	COG0022	dehydrogenase e1 component
HUJ41_RS12480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUJ41_RS12500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUJ41_RS12505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUJ41_RS12520	COG1309	transcriptional regulator
HUJ41_RS12525	COG0604	alcohol dehydrogenase
HUJ41_RS12530	COG0305	Participates in initiation and elongation during chromosome replication
HUJ41_RS12535	COG0359	binds to the 23S rRNA
HUJ41_RS12540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUJ41_RS12550	COG0360	Binds together with S18 to 16S ribosomal RNA
HUJ41_RS12555	COG0617	tRNA 3'-terminal CCA addition
HUJ41_RS12575	COG3118	belongs to the thioredoxin family
HUJ41_RS12580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUJ41_RS12585	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUJ41_RS12595	COG1192	Involved in chromosome partitioning
HUJ41_RS12600	COG0357	Ribosomal RNA small subunit methyltransferase G
HUJ41_RS12610	COG0706	membrane insertase activity
HUJ41_RS12615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUJ41_RS12620	COG0594	ribonuclease P activity
HUJ41_RS12625	COG0230	Belongs to the bacterial ribosomal protein bL34 family