locus-tag	class	description
HVY06_RS00010	COG0592	DNA-directed DNA polymerase activity
HVY06_RS00025	COG0561	phosphatase activity
HVY06_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HVY06_RS00040	COG5645	(Lipo)protein
HVY06_RS00060	COG2149	membrane
HVY06_RS00070	COG0641	radical SAM
HVY06_RS00080	COG2610	gluconate transmembrane transporter activity
HVY06_RS00085	COG0583	DNA-binding transcription factor activity
HVY06_RS00095	COG2814	Major facilitator Superfamily
HVY06_RS00115	COG0028	Belongs to the TPP enzyme family
HVY06_RS00120	COG0440	acetolactate synthase activity
HVY06_RS00125	COG2197	response regulator
HVY06_RS00155	COG4580	involved in the transport of maltose and maltodextrins
HVY06_RS00160	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY06_RS00165	COG2723	6-phospho-beta-galactosidase activity
HVY06_RS00170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY06_RS00170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY06_RS00175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY06_RS00180	COG1609	Transcriptional regulator
HVY06_RS00195	COG5464	transposase or invertase
HVY06_RS00200	COG1464	Belongs to the NlpA lipoprotein family
HVY06_RS00205	COG0697	spore germination
HVY06_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS00230	COG0583	DNA-binding transcription factor activity
HVY06_RS00240	COG3539	Fimbrial protein
HVY06_RS00260	COG2197	response regulator
HVY06_RS00280	COG2771	luxR family
HVY06_RS00335	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY06_RS00340	COG2982	Protein involved in outer membrane biogenesis
HVY06_RS00345	COG2233	PERMEase
HVY06_RS00350	COG0786	glutamate:sodium symporter activity
HVY06_RS00355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVY06_RS00360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY06_RS00365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY06_RS00385	COG2860	membrane
HVY06_RS00390	COG1561	YicC-like family, N-terminal region
HVY06_RS00400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HVY06_RS00415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVY06_RS00430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HVY06_RS00445	COG1519	Transferase
HVY06_RS00450	COG0438	transferase activity, transferring glycosyl groups
HVY06_RS00455	COG0515	serine threonine protein kinase
HVY06_RS00460	COG1442	glycosyl transferase family 8
HVY06_RS00465	COG1442	glycosyl transferase family 8
HVY06_RS00475	COG0859	PFAM glycosyl transferase family 9
HVY06_RS00480	COG1215	transferase activity, transferring glycosyl groups
HVY06_RS00485	COG3307	-O-antigen
HVY06_RS00495	COG0859	PFAM glycosyl transferase family 9
HVY06_RS00505	COG0156	8-amino-7-oxononanoate synthase activity
HVY06_RS00515	COG1216	Glycosyl transferase, family 2
HVY06_RS00520	COG2861	carbohydrate metabolic process
HVY06_RS00525	COG4942	peptidase
HVY06_RS00535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY06_RS00540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY06_RS00555	COG1045	serine acetyltransferase
HVY06_RS00560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVY06_RS00565	COG2271	Major facilitator Superfamily
HVY06_RS00575	COG2186	Transcriptional regulator
HVY06_RS00595	COG3722	fumarate hydratase activity
HVY06_RS00605	COG2213	PTS system mannitol-specific
HVY06_RS00605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS00615	COG1566	PFAM secretion protein HlyD family protein
HVY06_RS00620	COG0625	glutathione transferase activity
HVY06_RS00630	COG3276	selenocysteine insertion sequence binding
HVY06_RS00635	COG1454	alcohol dehydrogenase
HVY06_RS00640	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS00650	COG1566	PFAM secretion protein HlyD family protein
HVY06_RS00655	COG0583	DNA-binding transcription factor activity
HVY06_RS00660	COG3713	MltA-interacting MipA family protein
HVY06_RS00670	COG2211	Major facilitator Superfamily
HVY06_RS00680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY06_RS00685	COG3977	Valine--pyruvate aminotransferase
HVY06_RS00690	COG0366	Alpha amylase catalytic
HVY06_RS00695	COG2992	FlgJ-related protein
HVY06_RS00700	COG1609	Transcriptional regulator
HVY06_RS00700	COG2207	Transcriptional regulator
HVY06_RS00710	COG1070	Carbohydrate kinase
HVY06_RS00715	COG4682	membrane
HVY06_RS00720	COG3274	enterobacterial common antigen metabolic process
HVY06_RS00745	COG1278	Cold shock
HVY06_RS00750	COG2944	sequence-specific DNA binding
HVY06_RS00765	COG2271	Major facilitator Superfamily
HVY06_RS00770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS00780	COG1609	Transcriptional regulator
HVY06_RS00785	COG2885	chlorophyll binding
HVY06_RS00790	COG0243	molybdopterin cofactor binding
HVY06_RS00795	COG0456	acetyltransferase
HVY06_RS00800	COG2818	Glycosylase
HVY06_RS00805	COG5571	outer membrane autotransporter
HVY06_RS00810	COG2223	nitrite transmembrane transporter activity
HVY06_RS00835	COG0747	negative chemotaxis
HVY06_RS00840	COG0601	transmembrane transport
HVY06_RS00845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY06_RS00850	COG0444	Belongs to the ABC transporter superfamily
HVY06_RS00855	COG4608	Belongs to the ABC transporter superfamily
HVY06_RS00860	COG2204	response regulator
HVY06_RS00865	COG0814	amino acid
HVY06_RS00870	COG0626	cystathionine gamma-synthase activity
HVY06_RS00875	COG2199	diguanylate cyclase activity
HVY06_RS00875	COG2200	EAL domain
HVY06_RS00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS00895	COG2200	EAL domain
HVY06_RS00900	COG2982	Protein involved in outer membrane biogenesis
HVY06_RS00905	COG0477	Major facilitator Superfamily
HVY06_RS00910	COG1295	ribonuclease BN
HVY06_RS00915	COG0583	DNA-binding transcription factor activity
HVY06_RS00925	COG2197	response regulator
HVY06_RS00955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY06_RS00960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVY06_RS00965	COG0339	signal peptide processing
HVY06_RS00990	COG0589	response to stress
HVY06_RS01000	COG0306	phosphate transporter
HVY06_RS01005	COG2081	HI0933 family
HVY06_RS01020	COG3479	Phenolic acid decarboxylase
HVY06_RS01025	COG2091	lysine biosynthetic process via aminoadipic acid
HVY06_RS01030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY06_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS01045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY06_RS01070	COG1216	Glycosyl transferase, family 2
HVY06_RS01090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVY06_RS01120	COG0628	permease
HVY06_RS01135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVY06_RS01150	COG3714	YhhN family
HVY06_RS01160	COG3157	Type VI secretion system effector, Hcp
HVY06_RS01175	COG3776	membrane
HVY06_RS01180	COG0742	ribosomal rna small subunit methyltransferase
HVY06_RS01185	COG0552	protein localization to endoplasmic reticulum
HVY06_RS01190	COG2884	Cell division ATP-binding protein ftsE
HVY06_RS01195	COG2177	Part of the ABC transporter FtsEX involved in
HVY06_RS01215	COG0683	leucine binding
HVY06_RS01225	COG4177	L-phenylalanine transmembrane transporter activity
HVY06_RS01230	COG0411	ABC transporter
HVY06_RS01255	COG1175	transmembrane transport
HVY06_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
HVY06_RS01280	COG0405	Gamma-glutamyltransferase
HVY06_RS01305	COG3157	Type VI secretion system effector, Hcp
HVY06_RS01315	COG1247	-acetyltransferase
HVY06_RS01320	COG0673	inositol 2-dehydrogenase activity
HVY06_RS01325	COG1741	Belongs to the pirin family
HVY06_RS01330	COG1609	Transcriptional regulator
HVY06_RS01335	COG3265	gluconokinase activity
HVY06_RS01340	COG2610	gluconate transmembrane transporter activity
HVY06_RS01350	COG2095	MarC family integral membrane protein
HVY06_RS01355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY06_RS01380	COG0058	SHG alpha-glucan phosphorylase activity
HVY06_RS01385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY06_RS01400	COG1349	DNA-binding transcription factor activity
HVY06_RS01410	COG0058	SHG alpha-glucan phosphorylase activity
HVY06_RS01415	COG1640	4-alpha-glucanotransferase
HVY06_RS01420	COG2610	gluconate transmembrane transporter activity
HVY06_RS01430	COG1040	competence protein
HVY06_RS01450	COG1918	ferrous iron import across plasma membrane
HVY06_RS01455	COG2183	response to ionizing radiation
HVY06_RS01460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY06_RS01465	COG0745	RESPONSE REGULATOR receiver
HVY06_RS01490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY06_RS01500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVY06_RS01505	COG1011	Hydrolase
HVY06_RS01515	COG0494	nUDIX hydrolase
HVY06_RS01520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVY06_RS01525	COG4972	Pilus assembly protein
HVY06_RS01545	COG4796	Type ii and iii secretion system protein
HVY06_RS01560	COG3266	domain, Protein
HVY06_RS01565	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY06_RS01570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY06_RS01580	COG0180	Tryptophanyl-tRNA synthetase
HVY06_RS01600	COG2146	nitrite reductase [NAD(P)H] activity
HVY06_RS01605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY06_RS01630	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY06_RS01635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY06_RS01640	COG1289	transmembrane transporter activity
HVY06_RS01650	COG1765	OsmC-like protein
HVY06_RS01655	COG3954	Phosphoribulokinase
HVY06_RS01665	COG0429	hydrolase of the alpha beta-hydrolase fold
HVY06_RS01675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVY06_RS01710	COG0679	Auxin Efflux Carrier
HVY06_RS01720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVY06_RS01730	COG0488	(ABC) transporter
HVY06_RS01745	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVY06_RS01750	COG1047	Peptidyl-prolyl cis-trans
HVY06_RS01760	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY06_RS01765	COG2964	Protein conserved in bacteria
HVY06_RS01795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HVY06_RS01800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HVY06_RS01820	COG0051	transcription antitermination factor activity, RNA binding
HVY06_RS01830	COG0088	Forms part of the polypeptide exit tunnel
HVY06_RS01845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HVY06_RS01920	COG0200	Binds to the 23S rRNA
HVY06_RS01925	COG0201	protein transport
HVY06_RS01940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HVY06_RS01955	COG0203	ribosomal protein L17
HVY06_RS01965	COG0789	Transcriptional regulator
HVY06_RS01970	COG3036	rescue of stalled ribosome
HVY06_RS02000	COG0758	DNA mediated transformation
HVY06_RS02010	COG0551	DNA topoisomerase type I activity
HVY06_RS02030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY06_RS02080	COG1309	transcriptional regulator
HVY06_RS02095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY06_RS02100	COG1027	Aspartate ammonia-lyase
HVY06_RS02105	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVY06_RS02110	COG0531	amino acid
HVY06_RS02135	COG1509	lysine 2,3-aminomutase activity
HVY06_RS02180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY06_RS02185	COG1053	succinate dehydrogenase
HVY06_RS02200	COG3264	Mechanosensitive ion channel
HVY06_RS02200	COG1511	domain protein
HVY06_RS02235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVY06_RS02240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVY06_RS02240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVY06_RS02245	COG0802	atpase or kinase
HVY06_RS02250	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY06_RS02265	COG1923	regulation of RNA biosynthetic process
HVY06_RS02270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVY06_RS02275	COG0330	HflC and HflK could
HVY06_RS02280	COG0330	HflC and HflK could
HVY06_RS02285	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVY06_RS02300	COG0557	exoribonuclease II activity
HVY06_RS02305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY06_RS02310	COG3789	protein conserved in bacteria
HVY06_RS02315	COG1842	Phage shock protein A
HVY06_RS02325	COG3766	membrane
HVY06_RS02330	COG5463	Belongs to the UPF0441 family
HVY06_RS02335	COG0754	glutathionylspermidine amidase activity
HVY06_RS02340	COG1960	acyl-CoA dehydrogenase activity
HVY06_RS02350	COG3650	response to hydrogen peroxide
HVY06_RS02355	COG1073	alpha beta
HVY06_RS02405	COG0730	response to heat
HVY06_RS02415	COG2965	DNA replication, synthesis of RNA primer
HVY06_RS02420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVY06_RS02435	COG3061	Opacity-associated protein A
HVY06_RS02440	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY06_RS02445	COG1113	amino acid transport
HVY06_RS02455	COG0840	transmembrane signaling receptor activity
HVY06_RS02460	COG0697	spore germination
HVY06_RS02470	COG0702	epimerase
HVY06_RS02475	COG1733	regulation of RNA biosynthetic process
HVY06_RS02485	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVY06_RS02490	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY06_RS02500	COG1253	flavin adenine dinucleotide binding
HVY06_RS02510	COG2211	Major facilitator Superfamily
HVY06_RS02530	COG0673	inositol 2-dehydrogenase activity
HVY06_RS02535	COG1609	Transcriptional regulator
HVY06_RS02545	COG0729	surface antigen
HVY06_RS02550	COG2911	Protein conserved in bacteria
HVY06_RS02555	COG2105	PFAM AIG2 family protein
HVY06_RS02560	COG4771	TonB-dependent receptor
HVY06_RS02565	COG3391	amine dehydrogenase activity
HVY06_RS02575	COG1879	ABC-type sugar transport system periplasmic component
HVY06_RS02580	COG1129	ABC transporter
HVY06_RS02585	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS02590	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS02605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVY06_RS02615	COG0312	modulator of DNA gyrase
HVY06_RS02650	COG3964	amidohydrolase
HVY06_RS02665	COG3711	transcriptional antiterminator
HVY06_RS02665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS02670	COG3077	Addiction module antitoxin, RelB DinJ family
HVY06_RS02675	COG2026	Addiction module toxin, RelE StbE family
HVY06_RS02690	COG0366	Alpha amylase catalytic
HVY06_RS02695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS02695	COG1263	PTS System
HVY06_RS02710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY06_RS02745	COG2731	YhcH YjgK YiaL family protein
HVY06_RS02775	COG0525	valine-tRNA ligase activity
HVY06_RS02780	COG2927	DNA polymerase III (CHI subunit)
HVY06_RS02790	COG0795	lipopolysaccharide-transporting ATPase activity
HVY06_RS02795	COG0795	lipopolysaccharide-transporting ATPase activity
HVY06_RS02800	COG0433	COG0433 Predicted ATPase
HVY06_RS02805	COG1609	Transcriptional regulator
HVY06_RS02810	COG2610	gluconate transmembrane transporter activity
HVY06_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS02820	COG1063	alcohol dehydrogenase
HVY06_RS02825	COG3265	gluconokinase activity
HVY06_RS02830	COG1064	alcohol dehydrogenase
HVY06_RS02865	COG3423	Transcriptional regulator
HVY06_RS02905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY06_RS02910	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS02915	COG0531	amino acid
HVY06_RS02945	COG1620	l-lactate permease
HVY06_RS02950	COG0277	FAD linked oxidase domain protein
HVY06_RS02955	COG0247	lactate metabolic process
HVY06_RS02960	COG1139	Iron-sulfur cluster binding protein
HVY06_RS02965	COG1556	Lactate utilization protein
HVY06_RS02985	COG0477	Major facilitator Superfamily
HVY06_RS02995	COG2733	membrane
HVY06_RS03005	COG1301	dicarboxylic acid transport
HVY06_RS03010	COG0626	cystathionine gamma-synthase activity
HVY06_RS03020	COG5464	transposase or invertase
HVY06_RS03025	COG0523	cobalamin synthesis protein
HVY06_RS03030	COG2879	small protein
HVY06_RS03035	COG1966	Carbon starvation protein
HVY06_RS03040	COG0840	transmembrane signaling receptor activity
HVY06_RS03045	COG2271	Major facilitator Superfamily
HVY06_RS03050	COG1802	Transcriptional regulator
HVY06_RS03055	COG1063	alcohol dehydrogenase
HVY06_RS03070	COG1484	DNA-dependent DNA replication
HVY06_RS03085	COG2966	Psort location CytoplasmicMembrane, score
HVY06_RS03090	COG2197	response regulator
HVY06_RS03095	COG2197	response regulator
HVY06_RS03100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY06_RS03105	COG4114	ferric iron reductase
HVY06_RS03110	COG3706	GGDEF domain
HVY06_RS03140	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVY06_RS03145	COG0456	acetyltransferase
HVY06_RS03150	COG1011	Hydrolase
HVY06_RS03160	COG2823	Periplasmic or secreted lipoprotein
HVY06_RS03165	COG5487	UPF0391 membrane protein
HVY06_RS03170	COG4667	esterase of the alpha-beta hydrolase superfamily
HVY06_RS03175	COG0084	hydrolase, TatD family'
HVY06_RS03180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY06_RS03185	COG1328	CTP reductase activity
HVY06_RS03215	COG3726	membrane protein affecting hemolysin expression
HVY06_RS03220	COG0560	Phosphoserine phosphatase
HVY06_RS03235	COG0488	(ABC) transporter
HVY06_RS03240	COG0741	lytic transglycosylase activity
HVY06_RS03260	COG3708	Transcriptional regulator
HVY06_RS03260	COG2207	Transcriptional regulator
HVY06_RS03265	COG3045	CreA protein
HVY06_RS03270	COG0745	RESPONSE REGULATOR receiver
HVY06_RS03275	COG2205	protein histidine kinase activity
HVY06_RS03280	COG4452	Inner membrane protein CreD
HVY06_RS03285	COG0745	RESPONSE REGULATOR receiver
HVY06_RS03295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVY06_RS03305	COG0527	aspartate kinase activity
HVY06_RS03305	COG0460	homoserine dehydrogenase
HVY06_RS03315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVY06_RS03325	COG1115	amino acid carrier protein
HVY06_RS03335	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY06_RS03345	COG1584	GPR1 FUN34 yaaH family protein
HVY06_RS03355	COG0443	Heat shock 70 kDa protein
HVY06_RS03370	COG0583	DNA-binding transcription factor activity
HVY06_RS03380	COG0196	riboflavin kinase activity
HVY06_RS03395	COG1047	Peptidyl-prolyl cis-trans
HVY06_RS03415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HVY06_RS03425	COG0505	Belongs to the CarA family
HVY06_RS03480	COG0644	oxidoreductase
HVY06_RS03490	COG2271	Major facilitator Superfamily
HVY06_RS03535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY06_RS03550	COG0564	pseudouridine synthase activity
HVY06_RS03560	COG0417	DNA replication proofreading
HVY06_RS03570	COG0235	Class ii aldolase
HVY06_RS03590	COG0586	Pfam SNARE associated Golgi protein
HVY06_RS03600	COG1178	ABC-type Fe3 transport system permease component
HVY06_RS03620	COG2814	Major facilitator Superfamily
HVY06_RS03635	COG0473	3-isopropylmalate dehydrogenase activity
HVY06_RS03655	COG0028	Belongs to the TPP enzyme family
HVY06_RS03685	COG0768	penicillin binding
HVY06_RS03690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY06_RS03695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVY06_RS03710	COG0772	Belongs to the SEDS family
HVY06_RS03725	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY06_RS03735	COG0849	cell division
HVY06_RS03740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVY06_RS03760	COG0494	nUDIX hydrolase
HVY06_RS03775	COG0237	dephospho-CoA kinase activity
HVY06_RS03785	COG1459	type II secretion system
HVY06_RS03790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY06_RS03795	COG4969	Belongs to the N-Me-Phe pilin family
HVY06_RS03810	COG3725	Membrane protein required for beta-lactamase induction
HVY06_RS03815	COG3940	Belongs to the glycosyl hydrolase 43 family
HVY06_RS03820	COG2211	Major facilitator Superfamily
HVY06_RS03830	COG2186	Transcriptional regulator
HVY06_RS03835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVY06_RS03840	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY06_RS03845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY06_RS03855	COG3064	Membrane
HVY06_RS03885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVY06_RS03890	COG0288	reversible hydration of carbon dioxide
HVY06_RS03895	COG1131	(ABC) transporter
HVY06_RS03900	COG0842	Transport permease protein
HVY06_RS03905	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS03910	COG0726	polysaccharide deacetylase
HVY06_RS03915	COG3539	Fimbrial protein
HVY06_RS03935	COG3188	usher protein
HVY06_RS03940	COG3121	Chaperone
HVY06_RS03945	COG3539	Fimbrial protein
HVY06_RS03955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HVY06_RS03965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVY06_RS03970	COG0617	tRNA 3'-terminal CCA addition
HVY06_RS03990	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVY06_RS03995	COG1643	Atp-dependent helicase
HVY06_RS04000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY06_RS04005	COG4774	siderophore transport
HVY06_RS04010	COG1120	ATPase activity
HVY06_RS04015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY06_RS04040	COG2860	membrane
HVY06_RS04060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY06_RS04065	COG3835	regulator
HVY06_RS04110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVY06_RS04120	COG0575	Belongs to the CDS family
HVY06_RS04135	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVY06_RS04180	COG0346	lactoylglutathione lyase activity
HVY06_RS04190	COG4568	rho-dependent transcription termination
HVY06_RS04205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY06_RS04210	COG3015	lipoprotein NlpE involved in copper resistance
HVY06_RS04220	COG1720	tRNA m6t6A37 methyltransferase activity
HVY06_RS04230	COG1464	Belongs to the NlpA lipoprotein family
HVY06_RS04235	COG2011	ABC-type metal ion transport system permease component
HVY06_RS04245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY06_RS04280	COG0583	DNA-binding transcription factor activity
HVY06_RS04285	COG2814	Major facilitator Superfamily
HVY06_RS04295	COG2226	methyltransferase
HVY06_RS04300	COG0741	lytic transglycosylase activity
HVY06_RS04300	COG1388	LysM domain
HVY06_RS04310	COG2226	methyltransferase
HVY06_RS04320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY06_RS04335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY06_RS04340	COG1960	acyl-CoA dehydrogenase activity
HVY06_RS04350	COG0121	glutamine amidotransferase
HVY06_RS04355	COG3034	peptidoglycan biosynthetic process
HVY06_RS04360	COG0791	NLP P60 protein
HVY06_RS04370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVY06_RS04375	COG1684	flagellar biosynthetic protein fliR
HVY06_RS04380	COG1987	bacterial-type flagellum assembly
HVY06_RS04405	COG1677	Flagellar hook-basal body complex protein FliE
HVY06_RS04415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY06_RS04460	COG2089	acid synthase
HVY06_RS04465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVY06_RS04470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY06_RS04510	COG1558	bacterial-type flagellum-dependent cell motility
HVY06_RS04525	COG4787	bacterial-type flagellum-dependent cell motility
HVY06_RS04530	COG4786	Flagellar basal body rod
HVY06_RS04550	COG1256	bacterial-type flagellum assembly
HVY06_RS04550	COG4786	Flagellar basal body rod
HVY06_RS04575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVY06_RS04580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVY06_RS04605	COG1191	sigma factor activity
HVY06_RS04610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVY06_RS04630	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY06_RS04675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVY06_RS04680	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS04685	COG1396	sequence-specific DNA binding
HVY06_RS04685	COG1917	Cupin 2, conserved barrel domain protein
HVY06_RS04690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVY06_RS04695	COG0174	glutamine synthetase
HVY06_RS04700	COG0531	amino acid
HVY06_RS04720	COG2957	Belongs to the agmatine deiminase family
HVY06_RS04725	COG0693	protein deglycase activity
HVY06_RS04745	COG0348	domain, Protein
HVY06_RS04750	COG3706	GGDEF domain
HVY06_RS04755	COG1280	lysine exporter protein (LysE YggA)
HVY06_RS04765	COG3829	transcription factor binding
HVY06_RS04775	COG0372	Belongs to the citrate synthase family
HVY06_RS04780	COG2079	MmgE PrpD family protein
HVY06_RS04790	COG2223	nitrite transmembrane transporter activity
HVY06_RS04800	COG1609	Transcriptional regulator
HVY06_RS04815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVY06_RS04870	COG5001	Diguanylate cyclase
HVY06_RS04870	COG3300	MHYT domain
HVY06_RS04875	COG1414	Transcriptional regulator
HVY06_RS04910	COG2814	Major facilitator Superfamily
HVY06_RS04915	COG0833	amino acid
HVY06_RS04920	COG2040	homocysteine
HVY06_RS04925	COG3842	ATPase activity
HVY06_RS04935	COG1840	ABC-type Fe3 transport system, periplasmic component
HVY06_RS04940	COG2271	Major facilitator Superfamily
HVY06_RS04955	COG4521	taurine ABC transporter
HVY06_RS04960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HVY06_RS04965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY06_RS04970	COG2175	clavaminate synthase activity
HVY06_RS04975	COG0113	porphobilinogen synthase activity
HVY06_RS04980	COG3468	outer membrane autotransporter barrel domain protein
HVY06_RS04985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY06_RS04990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY06_RS04995	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVY06_RS05015	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY06_RS05030	COG1785	Belongs to the alkaline phosphatase family
HVY06_RS05040	COG3706	GGDEF domain
HVY06_RS05045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVY06_RS05065	COG4126	flavin adenine dinucleotide binding
HVY06_RS05070	COG3123	guanosine phosphorylase activity
HVY06_RS05080	COG1940	carbohydrate kinase activity
HVY06_RS05085	COG2814	Major facilitator Superfamily
HVY06_RS05090	COG0419	ATPase involved in DNA repair
HVY06_RS05095	COG0420	3'-5' exonuclease activity
HVY06_RS05105	COG5002	protein histidine kinase activity
HVY06_RS05120	COG0366	Alpha amylase catalytic
HVY06_RS05125	COG0450	alkyl hydroperoxide reductase
HVY06_RS05135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HVY06_RS05145	COG1862	Preprotein translocase
HVY06_RS05150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY06_RS05155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY06_RS05160	COG3248	Nucleoside-binding outer membrane protein
HVY06_RS05165	COG4238	major outer membrane lipoprotein
HVY06_RS05175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY06_RS05175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY06_RS05190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HVY06_RS05195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVY06_RS05200	COG0667	Aldo Keto reductase
HVY06_RS05210	COG0142	geranyltranstransferase activity
HVY06_RS05245	COG2814	Major facilitator Superfamily
HVY06_RS05255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVY06_RS05260	COG1845	cytochrome c oxidase, subunit III
HVY06_RS05265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVY06_RS05270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVY06_RS05275	COG2223	nitrite transmembrane transporter activity
HVY06_RS05280	COG3056	Lipoprotein
HVY06_RS05285	COG0271	Belongs to the BolA IbaG family
HVY06_RS05305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVY06_RS05310	COG0776	regulation of translation
HVY06_RS05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY06_RS05320	COG1555	photosystem II stabilization
HVY06_RS05325	COG0824	Thioesterase
HVY06_RS05335	COG4533	DNA binding
HVY06_RS05350	COG1522	sequence-specific DNA binding
HVY06_RS05355	COG1132	(ABC) transporter
HVY06_RS05360	COG1132	(ABC) transporter
HVY06_RS05365	COG0347	Belongs to the P(II) protein family
HVY06_RS05370	COG0004	ammonium transporteR
HVY06_RS05375	COG1946	Acyl-CoA thioesterase
HVY06_RS05380	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVY06_RS05385	COG3695	enzyme binding
HVY06_RS05395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY06_RS05400	COG2364	Membrane
HVY06_RS05405	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVY06_RS05410	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY06_RS05440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY06_RS05445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY06_RS05450	COG1309	transcriptional regulator
HVY06_RS05455	COG1196	nuclear chromosome segregation
HVY06_RS05455	COG3264	Mechanosensitive ion channel
HVY06_RS05465	COG3923	Primosomal replication protein n
HVY06_RS05470	COG2832	Protein of unknown function (DUF454)
HVY06_RS05505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY06_RS05505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS05505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY06_RS05510	COG1882	Formate acetyltransferase
HVY06_RS05535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS05540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY06_RS05540	COG4651	solute:proton antiporter activity
HVY06_RS05545	COG2223	nitrite transmembrane transporter activity
HVY06_RS05560	COG3735	TraB family
HVY06_RS05565	COG2217	Heavy metal translocating P-type atpase
HVY06_RS05585	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY06_RS05590	COG0330	HflC and HflK could
HVY06_RS05595	COG4619	ABC transporter
HVY06_RS05600	COG0390	transport system, permease component
HVY06_RS05605	COG3118	belongs to the thioredoxin family
HVY06_RS05610	COG0300	oxidoreductase activity
HVY06_RS05615	COG2755	lipolytic protein G-D-S-L family
HVY06_RS05620	COG4181	ATPase activity
HVY06_RS05625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVY06_RS05635	COG1464	Belongs to the NlpA lipoprotein family
HVY06_RS05645	COG2011	ABC-type metal ion transport system permease component
HVY06_RS05655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVY06_RS05660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVY06_RS05670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY06_RS05680	COG1988	membrane-bound metal-dependent
HVY06_RS05685	COG2501	S4 domain
HVY06_RS05775	COG2003	Belongs to the UPF0758 family
HVY06_RS05805	COG3596	GTP binding
HVY06_RS05845	COG0463	Glycosyl transferase, family 2
HVY06_RS05850	COG2246	polysaccharide biosynthetic process
HVY06_RS05860	COG3005	denitrification pathway
HVY06_RS05865	COG0243	molybdopterin cofactor binding
HVY06_RS05870	COG0321	lipoyl(octanoyl) transferase activity
HVY06_RS05870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVY06_RS05895	COG5002	protein histidine kinase activity
HVY06_RS05900	COG0745	RESPONSE REGULATOR receiver
HVY06_RS05905	COG1538	Outer membrane efflux protein
HVY06_RS05910	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY06_RS05915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY06_RS05920	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY06_RS05925	COG2207	Transcriptional regulator
HVY06_RS05930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY06_RS05940	COG3059	membrane
HVY06_RS05955	COG5001	Diguanylate cyclase
HVY06_RS05955	COG3300	MHYT domain
HVY06_RS05980	COG1113	amino acid transport
HVY06_RS05985	COG2211	Major facilitator Superfamily
HVY06_RS06005	COG0668	transmembrane transport
HVY06_RS06015	COG2315	Protein conserved in bacteria
HVY06_RS06055	COG2977	Belongs to the P-Pant transferase superfamily
HVY06_RS06060	COG4771	TonB-dependent receptor
HVY06_RS06065	COG2382	esterase
HVY06_RS06070	COG3251	PFAM MbtH domain protein
HVY06_RS06075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVY06_RS06075	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVY06_RS06080	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY06_RS06085	COG1120	ATPase activity
HVY06_RS06090	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY06_RS06095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY06_RS06105	COG4592	Periplasmic binding protein
HVY06_RS06110	COG1169	isochorismate synthase
HVY06_RS06115	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVY06_RS06120	COG1535	isochorismatase
HVY06_RS06120	COG3433	isochorismatase activity
HVY06_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS06135	COG1966	Carbon starvation protein
HVY06_RS06140	COG2879	small protein
HVY06_RS06145	COG0371	Dehydrogenase
HVY06_RS06150	COG0436	Aminotransferase
HVY06_RS06155	COG1475	DNA binding
HVY06_RS06160	COG3969	phosphoadenosine phosphosulfate
HVY06_RS06170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY06_RS06180	COG3634	alkyl hydroperoxide reductase activity
HVY06_RS06190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY06_RS06195	COG3719	Belongs to the RNase T2 family
HVY06_RS06200	COG0471	metal ion transport
HVY06_RS06215	COG3051	citrate lyase alpha subunit
HVY06_RS06220	COG2301	Belongs to the HpcH HpaI aldolase family
HVY06_RS06230	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVY06_RS06235	COG3290	protein histidine kinase activity
HVY06_RS06240	COG4565	transcriptional regulatory protein
HVY06_RS06245	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY06_RS06265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY06_RS06290	COG1686	Belongs to the peptidase S11 family
HVY06_RS06295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY06_RS06300	COG0772	Belongs to the SEDS family
HVY06_RS06305	COG0768	penicillin binding
HVY06_RS06315	COG0799	negative regulation of ribosome biogenesis
HVY06_RS06325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HVY06_RS06335	COG1466	dna polymerase III delta subunit
HVY06_RS06350	COG2888	peptidyl-tyrosine sulfation
HVY06_RS06360	COG1126	abc transporter atp-binding protein
HVY06_RS06365	COG0765	amino acid transport
HVY06_RS06370	COG0765	amino acid transport
HVY06_RS06395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HVY06_RS06400	COG1702	phosphate starvation-inducible protein PhoH
HVY06_RS06410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY06_RS06450	COG0367	asparagine synthase
HVY06_RS06455	COG0647	UMP catabolic process
HVY06_RS06460	COG1940	carbohydrate kinase activity
HVY06_RS06460	COG1846	Transcriptional regulator
HVY06_RS06465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY06_RS06475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS06475	COG2190	(PTS) system
HVY06_RS06475	COG1263	PTS System
HVY06_RS06495	COG0735	belongs to the Fur family
HVY06_RS06515	COG0596	Alpha beta hydrolase
HVY06_RS06525	COG0033	Phosphoglucomutase
HVY06_RS06530	COG0745	RESPONSE REGULATOR receiver
HVY06_RS06535	COG2205	protein histidine kinase activity
HVY06_RS06565	COG3272	Protein of unknown function (DUF1722)
HVY06_RS06575	COG5464	transposase or invertase
HVY06_RS06585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVY06_RS06590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVY06_RS06595	COG1984	allophanate hydrolase subunit 2
HVY06_RS06630	COG3180	Ammonia monooxygenase
HVY06_RS06640	COG2009	succinate dehydrogenase
HVY06_RS06645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVY06_RS06650	COG1053	succinate dehydrogenase
HVY06_RS06655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY06_RS06660	COG0567	Dehydrogenase, E1 component
HVY06_RS06665	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY06_RS06675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY06_RS06685	COG1648	precorrin-2 dehydrogenase activity
HVY06_RS06685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HVY06_RS06690	COG0583	DNA-binding transcription factor activity
HVY06_RS06700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY06_RS06700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY06_RS06710	COG1301	dicarboxylic acid transport
HVY06_RS06725	COG3799	methylaspartate ammonia-lyase activity
HVY06_RS06730	COG4865	methylaspartate mutase activity
HVY06_RS06740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY06_RS06745	COG1271	oxidase subunit
HVY06_RS06750	COG1294	oxidase, subunit
HVY06_RS06755	COG4890	Cyd operon protein YbgT
HVY06_RS06760	COG3790	cyd operon protein YbgE
HVY06_RS06765	COG0824	Thioesterase
HVY06_RS06770	COG0811	peptide transport
HVY06_RS06775	COG0848	biopolymer transport protein
HVY06_RS06780	COG3064	Membrane
HVY06_RS06790	COG2885	chlorophyll binding
HVY06_RS06795	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVY06_RS06830	COG3201	nicotinamide mononucleotide transporter
HVY06_RS06835	COG1230	cation diffusion facilitator family transporter
HVY06_RS06845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY06_RS06855	COG2017	converts alpha-aldose to the beta-anomer
HVY06_RS06865	COG1085	galactose-1-phosphate uridylyltransferase
HVY06_RS06870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVY06_RS06875	COG1119	ATPase activity
HVY06_RS06880	COG3585	molybdate ion transport
HVY06_RS06880	COG2005	Transcriptional regulator
HVY06_RS06890	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVY06_RS06895	COG4149	molybdate abc transporter
HVY06_RS06905	COG0561	phosphatase activity
HVY06_RS06915	COG0583	DNA-binding transcription factor activity
HVY06_RS06920	COG2828	Protein conserved in bacteria
HVY06_RS06925	COG0471	metal ion transport
HVY06_RS06930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY06_RS06935	COG4677	pectinesterase activity
HVY06_RS06965	COG1881	PFAM PEBP family protein
HVY06_RS07015	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY06_RS07025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVY06_RS07030	COG0314	molybdopterin synthase activity
HVY06_RS07035	COG0670	Belongs to the BI1 family
HVY06_RS07040	COG0392	lysyltransferase activity
HVY06_RS07045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY06_RS07050	COG3568	Endonuclease Exonuclease Phosphatase
HVY06_RS07060	COG0842	Transport permease protein
HVY06_RS07065	COG0842	Transport permease protein
HVY06_RS07070	COG1131	(ABC) transporter
HVY06_RS07080	COG1309	transcriptional regulator
HVY06_RS07085	COG0513	Belongs to the DEAD box helicase family
HVY06_RS07095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY06_RS07100	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY06_RS07110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY06_RS07135	COG0668	transmembrane transport
HVY06_RS07140	COG1126	abc transporter atp-binding protein
HVY06_RS07145	COG0765	amino acid transport
HVY06_RS07150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY06_RS07165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVY06_RS07170	COG2194	sulfuric ester hydrolase activity
HVY06_RS07185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY06_RS07190	COG1376	ErfK ybiS ycfS ynhG family protein
HVY06_RS07195	COG0488	(ABC) transporter
HVY06_RS07215	COG0561	phosphatase activity
HVY06_RS07220	COG1882	Formate acetyltransferase
HVY06_RS07225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY06_RS07230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY06_RS07235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY06_RS07240	COG0303	'Molybdopterin
HVY06_RS07245	COG1446	asparaginase
HVY06_RS07275	COG0058	SHG alpha-glucan phosphorylase activity
HVY06_RS07280	COG0583	DNA-binding transcription factor activity
HVY06_RS07290	COG2133	pyrroloquinoline quinone binding
HVY06_RS07295	COG0625	glutathione transferase activity
HVY06_RS07300	COG1686	Belongs to the peptidase S11 family
HVY06_RS07305	COG1349	DNA-binding transcription factor activity
HVY06_RS07310	COG0671	phosphoesterase, PA-phosphatase related
HVY06_RS07315	COG2814	Major facilitator Superfamily
HVY06_RS07325	COG0561	phosphatase activity
HVY06_RS07330	COG0738	Major facilitator superfamily
HVY06_RS07335	COG3226	Transcriptional regulator
HVY06_RS07380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY06_RS07385	COG3842	ATPase activity
HVY06_RS07390	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY06_RS07395	COG1177	transmembrane transport
HVY06_RS07415	COG1335	isochorismatase
HVY06_RS07425	COG0583	DNA-binding transcription factor activity
HVY06_RS07430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HVY06_RS07445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVY06_RS07450	COG4988	ABC transporter
HVY06_RS07455	COG0492	ferredoxin-NADP+ reductase activity
HVY06_RS07460	COG1522	sequence-specific DNA binding
HVY06_RS07465	COG1674	ftsk spoiiie
HVY06_RS07465	COG1178	ABC-type Fe3 transport system permease component
HVY06_RS07475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVY06_RS07485	COG0243	molybdopterin cofactor binding
HVY06_RS07490	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS07495	COG3302	dmso reductase anchor subunit
HVY06_RS07505	COG0531	amino acid
HVY06_RS07515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY06_RS07520	COG1882	Formate acetyltransferase
HVY06_RS07525	COG2116	formate transmembrane transporter activity
HVY06_RS07530	COG1944	ATP diphosphatase activity
HVY06_RS07535	COG2323	membrane
HVY06_RS07555	COG0539	negative regulation of cytoplasmic translation
HVY06_RS07560	COG0776	regulation of translation
HVY06_RS07565	COG2333	competence protein COMEC
HVY06_RS07565	COG0658	competence protein
HVY06_RS07580	COG3214	Protein conserved in bacteria
HVY06_RS07595	COG3173	Aminoglycoside phosphotransferase
HVY06_RS07600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY06_RS07605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVY06_RS07615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVY06_RS07625	COG2989	Protein conserved in bacteria
HVY06_RS07630	COG3108	Peptidase M15
HVY06_RS07635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY06_RS07640	COG1448	Aminotransferase
HVY06_RS07660	COG0308	aminopeptidase N
HVY06_RS07670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY06_RS07680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY06_RS07685	COG0431	NADPH-dependent FMN reductase
HVY06_RS07700	COG3217	Mosc domain protein beta barrel domain protein
HVY06_RS07700	COG0633	Ferredoxin
HVY06_RS07710	COG0488	(ABC) transporter
HVY06_RS07715	COG2995	paraquat-inducible protein a
HVY06_RS07720	COG3008	intermembrane lipid transfer
HVY06_RS07720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY06_RS07725	COG3009	Protein conserved in bacteria
HVY06_RS07730	COG3130	regulation of translation
HVY06_RS07740	COG1067	ATP-dependent peptidase activity
HVY06_RS07760	COG3070	regulator of competence-specific genes
HVY06_RS07765	COG1289	transmembrane transporter activity
HVY06_RS07770	COG3304	Inner membrane component domain
HVY06_RS07775	COG0210	DNA helicase
HVY06_RS07790	COG1832	CoA-binding protein
HVY06_RS07810	COG2920	part of a sulfur-relay system
HVY06_RS07815	COG0670	Belongs to the BI1 family
HVY06_RS07850	COG2246	polysaccharide biosynthetic process
HVY06_RS07860	COG0656	L-ascorbic acid biosynthetic process
HVY06_RS07880	COG0386	Belongs to the glutathione peroxidase family
HVY06_RS07885	COG2814	Major facilitator Superfamily
HVY06_RS07895	COG1609	Transcriptional regulator
HVY06_RS07900	COG1757	Na H antiporter
HVY06_RS07905	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY06_RS07910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY06_RS07915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY06_RS07945	COG4232	protein-disulfide reductase activity
HVY06_RS07950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HVY06_RS07950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY06_RS07955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY06_RS07975	COG3729	General stress protein
HVY06_RS07980	COG1309	transcriptional regulator
HVY06_RS07985	COG3755	Protein conserved in bacteria
HVY06_RS07990	COG0506	proline dehydrogenase activity
HVY06_RS07990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY06_RS07990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY06_RS07995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY06_RS08015	COG1702	phosphate starvation-inducible protein PhoH
HVY06_RS08035	COG3381	protein complex oligomerization
HVY06_RS08090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY06_RS08110	COG5645	(Lipo)protein
HVY06_RS08125	COG1560	Kdo2-lipid A biosynthetic process
HVY06_RS08140	COG3038	cytochrome b561
HVY06_RS08180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY06_RS08220	COG1558	bacterial-type flagellum-dependent cell motility
HVY06_RS08235	COG4787	bacterial-type flagellum-dependent cell motility
HVY06_RS08240	COG4786	Flagellar basal body rod
HVY06_RS08270	COG2814	Major facilitator Superfamily
HVY06_RS08275	COG0583	DNA-binding transcription factor activity
HVY06_RS08280	COG1530	ribonuclease E activity
HVY06_RS08285	COG0564	pseudouridine synthase activity
HVY06_RS08295	COG1399	metal-binding, possibly nucleic acid-binding protein
HVY06_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS08330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY06_RS08335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY06_RS08340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVY06_RS08350	COG0470	DNA polymerase III
HVY06_RS08355	COG0084	hydrolase, TatD family'
HVY06_RS08370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVY06_RS08375	COG0477	Major facilitator Superfamily
HVY06_RS08390	COG0583	DNA-binding transcription factor activity
HVY06_RS08395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY06_RS08435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY06_RS08440	COG1418	mRNA catabolic process
HVY06_RS08445	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVY06_RS08450	COG3727	T/G mismatch-specific endonuclease activity
HVY06_RS08455	COG0697	spore germination
HVY06_RS08460	COG2354	Protein conserved in bacteria
HVY06_RS08465	COG5475	Uncharacterized small protein (DUF2158)
HVY06_RS08525	COG2882	bacterial-type flagellum organization
HVY06_RS08555	COG0425	Belongs to the sulfur carrier protein TusA family
HVY06_RS08570	COG0366	Alpha amylase catalytic
HVY06_RS08615	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HVY06_RS08630	COG2197	response regulator
HVY06_RS08640	COG2197	response regulator
HVY06_RS08695	COG1305	Transglutaminase-like
HVY06_RS08705	COG2608	mercury ion transmembrane transporter activity
HVY06_RS08710	COG3012	SEC-C Motif Domain Protein
HVY06_RS08710	COG3318	Belongs to the UPF0149 family
HVY06_RS08715	COG0814	amino acid
HVY06_RS08725	COG1528	Iron-storage protein
HVY06_RS08740	COG0477	Major facilitator Superfamily
HVY06_RS08750	COG1528	Iron-storage protein
HVY06_RS08760	COG1879	ABC-type sugar transport system periplasmic component
HVY06_RS08765	COG1129	ABC transporter
HVY06_RS08770	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS08815	COG0835	chemotaxis
HVY06_RS08820	COG1301	dicarboxylic acid transport
HVY06_RS08840	COG0745	RESPONSE REGULATOR receiver
HVY06_RS08870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HVY06_RS08885	COG3102	Protein conserved in bacteria
HVY06_RS08905	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVY06_RS08910	COG1801	Protein of unknown function DUF72
HVY06_RS08915	COG1335	isochorismatase
HVY06_RS08925	COG0494	nUDIX hydrolase
HVY06_RS08930	COG0217	transcriptional regulatory protein
HVY06_RS08950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY06_RS08960	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVY06_RS08965	COG0739	heme binding
HVY06_RS08970	COG1560	Kdo2-lipid A biosynthetic process
HVY06_RS08980	COG1737	Transcriptional regulator
HVY06_RS08985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVY06_RS08990	COG0129	dihydroxy-acid dehydratase activity
HVY06_RS08995	COG0800	Aldolase
HVY06_RS09000	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS09000	COG2030	dehydratase
HVY06_RS09005	COG3396	Phenylacetate-CoA oxygenase
HVY06_RS09010	COG3460	Phenylacetate-CoA oxygenase
HVY06_RS09015	COG3396	Phenylacetate-CoA oxygenase
HVY06_RS09020	COG2151	metal-sulfur cluster biosynthetic enzyme
HVY06_RS09025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY06_RS09030	COG1024	Enoyl-CoA hydratase
HVY06_RS09035	COG1024	Enoyl-CoA hydratase
HVY06_RS09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY06_RS09045	COG2050	protein possibly involved in aromatic compounds catabolism
HVY06_RS09050	COG0183	Belongs to the thiolase family
HVY06_RS09055	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVY06_RS09060	COG3327	negative regulation of DNA-templated transcription, initiation
HVY06_RS09065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY06_RS09070	COG4773	Receptor
HVY06_RS09075	COG0537	adenosine 5'-monophosphoramidase activity
HVY06_RS09080	COG5633	Lipoprotein
HVY06_RS09105	COG1252	NADH dehydrogenase
HVY06_RS09110	COG3134	Outer membrane lipoprotein
HVY06_RS09115	COG1309	transcriptional regulator
HVY06_RS09125	COG1376	ErfK ybiS ycfS ynhG family protein
HVY06_RS09125	COG1388	LysM domain
HVY06_RS09130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVY06_RS09135	COG4763	Acyl-transferase
HVY06_RS09140	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY06_RS09145	COG1136	(ABC) transporter
HVY06_RS09150	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY06_RS09160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY06_RS09165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY06_RS09170	COG1177	transmembrane transport
HVY06_RS09180	COG0582	viral genome integration into host DNA
HVY06_RS09190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY06_RS09205	COG1396	sequence-specific DNA binding
HVY06_RS09280	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVY06_RS09285	COG1403	HNH endonuclease
HVY06_RS09315	COG3179	chitinase
HVY06_RS09350	COG0740	serine-type endopeptidase activity
HVY06_RS09430	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY06_RS09435	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY06_RS09450	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY06_RS09475	COG2850	peptidyl-arginine hydroxylation
HVY06_RS09490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVY06_RS09515	COG1187	pseudouridine synthase activity
HVY06_RS09520	COG0538	isocitrate dehydrogenase activity
HVY06_RS09525	COG5562	phage envelope protein
HVY06_RS09545	COG2194	sulfuric ester hydrolase activity
HVY06_RS09555	COG4771	TonB-dependent receptor
HVY06_RS09560	COG0747	negative chemotaxis
HVY06_RS09565	COG0601	transmembrane transport
HVY06_RS09570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY06_RS09580	COG1124	(ABC) transporter
HVY06_RS09585	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVY06_RS09590	COG1335	isochorismatase
HVY06_RS09600	COG3615	Tellurite resistance protein tehB
HVY06_RS09615	COG3383	formate dehydrogenase (NAD+) activity
HVY06_RS09620	COG2261	transglycosylase associated protein
HVY06_RS09635	COG2199	diguanylate cyclase activity
HVY06_RS09635	COG2203	Gaf domain
HVY06_RS09640	COG3042	response to heat
HVY06_RS09645	COG3189	MarR family transcriptional regulator
HVY06_RS09650	COG0504	CTP synthase activity
HVY06_RS09655	COG2807	transmembrane transport
HVY06_RS09660	COG2207	Transcriptional regulator
HVY06_RS09670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY06_RS09675	COG2199	diguanylate cyclase activity
HVY06_RS09680	COG2226	methyltransferase
HVY06_RS09690	COG0110	maltose O-acetyltransferase activity
HVY06_RS09700	COG2766	serine protein kinase
HVY06_RS09705	COG3713	MltA-interacting MipA family protein
HVY06_RS09710	COG0656	L-ascorbic acid biosynthetic process
HVY06_RS09730	COG3139	Protein of unknown function (DUF1315)
HVY06_RS09740	COG1335	isochorismatase
HVY06_RS09745	COG0252	asparaginase activity
HVY06_RS09750	COG0616	signal peptide processing
HVY06_RS09755	COG0778	Nitroreductase
HVY06_RS09765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY06_RS09780	COG0494	nUDIX hydrolase
HVY06_RS09785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY06_RS09790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY06_RS09795	COG2897	thiosulfate sulfurtransferase activity
HVY06_RS09800	COG4136	ATPase activity
HVY06_RS09805	COG4135	transport system, permease component
HVY06_RS09810	COG4134	Bacterial extracellular solute-binding protein
HVY06_RS09815	COG0398	Pfam SNARE associated Golgi protein
HVY06_RS09820	COG0398	Pfam SNARE associated Golgi protein
HVY06_RS09825	COG0708	Exodeoxyribonuclease III
HVY06_RS09855	COG3678	ATP-independent chaperone mediated protein folding
HVY06_RS09865	COG0322	excinuclease ABC activity
HVY06_RS09875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY06_RS09880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY06_RS09885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY06_RS09890	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY06_RS09895	COG1917	Cupin 2, conserved barrel domain protein
HVY06_RS09895	COG2169	Transcriptional regulator
HVY06_RS09900	COG1486	melibiose metabolic process
HVY06_RS09910	COG0753	catalase activity
HVY06_RS09925	COG1988	membrane-bound metal-dependent
HVY06_RS09930	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS09935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY06_RS09945	COG3001	Fructosamine kinase
HVY06_RS09950	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY06_RS09955	COG3137	Salt-induced outer membrane protein
HVY06_RS09980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HVY06_RS09995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HVY06_RS10000	COG0072	phenylalanine-tRNA ligase activity
HVY06_RS10000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVY06_RS10015	COG0386	Belongs to the glutathione peroxidase family
HVY06_RS10025	COG0791	NLP P60 protein
HVY06_RS10045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY06_RS10050	COG4558	Periplasmic binding protein
HVY06_RS10055	COG3720	iron ion transport
HVY06_RS10060	COG4771	TonB-dependent receptor
HVY06_RS10065	COG4256	Hemin uptake protein
HVY06_RS10080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY06_RS10080	COG0574	Belongs to the PEP-utilizing enzyme family
HVY06_RS10085	COG0318	PFAM AMP-dependent synthetase and ligase
HVY06_RS10090	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY06_RS10095	COG0644	oxidoreductase
HVY06_RS10100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVY06_RS10105	COG2086	electron transfer activity
HVY06_RS10110	COG1917	Cupin 2, conserved barrel domain protein
HVY06_RS10110	COG2207	Transcriptional regulator
HVY06_RS10115	COG1960	acyl-CoA dehydrogenase activity
HVY06_RS10120	COG4670	ketone body catabolic process
HVY06_RS10135	COG2271	Major facilitator Superfamily
HVY06_RS10140	COG0738	Major facilitator superfamily
HVY06_RS10150	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY06_RS10160	COG0628	permease
HVY06_RS10165	COG0247	lactate metabolic process
HVY06_RS10165	COG0277	FAD linked oxidase domain protein
HVY06_RS10170	COG2050	protein possibly involved in aromatic compounds catabolism
HVY06_RS10185	COG0583	DNA-binding transcription factor activity
HVY06_RS10190	COG0316	Belongs to the HesB IscA family
HVY06_RS10195	COG0719	Fe-S assembly protein
HVY06_RS10200	COG0396	ATPase activity
HVY06_RS10205	COG0719	Fe-S assembly protein
HVY06_RS10220	COG1376	ErfK ybiS ycfS ynhG family protein
HVY06_RS10240	COG2011	ABC-type metal ion transport system permease component
HVY06_RS10245	COG1464	Belongs to the NlpA lipoprotein family
HVY06_RS10280	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS10285	COG2414	aldehyde ferredoxin oxidoreductase
HVY06_RS10295	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS10300	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HVY06_RS10310	COG0765	amino acid transport
HVY06_RS10325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY06_RS10340	COG3734	2-keto-3-deoxy-galactonokinase
HVY06_RS10345	COG0800	Aldolase
HVY06_RS10350	COG2271	Major facilitator Superfamily
HVY06_RS10355	COG0129	dihydroxy-acid dehydratase activity
HVY06_RS10360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY06_RS10365	COG1113	amino acid transport
HVY06_RS10380	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS10390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HVY06_RS10395	COG2010	Cytochrome c
HVY06_RS10405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY06_RS10430	COG0583	DNA-binding transcription factor activity
HVY06_RS10435	COG1388	LysM domain
HVY06_RS10435	COG1470	cell adhesion involved in biofilm formation
HVY06_RS10480	COG3706	GGDEF domain
HVY06_RS10485	COG0628	permease
HVY06_RS10495	COG1309	transcriptional regulator
HVY06_RS10530	COG0564	pseudouridine synthase activity
HVY06_RS10540	COG0307	riboflavin synthase, alpha
HVY06_RS10545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY06_RS10550	COG2814	Major facilitator Superfamily
HVY06_RS10555	COG0583	DNA-binding transcription factor activity
HVY06_RS10570	COG2814	Major facilitator Superfamily
HVY06_RS10575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY06_RS10580	COG0791	NLP P60 protein
HVY06_RS10585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVY06_RS10595	COG0346	lactoylglutathione lyase activity
HVY06_RS10600	COG1902	pentaerythritol trinitrate reductase activity
HVY06_RS10605	COG1309	transcriptional regulator
HVY06_RS10610	COG3313	Fe-S protein
HVY06_RS10615	COG4989	oxidoreductase activity
HVY06_RS10630	COG1566	PFAM secretion protein HlyD family protein
HVY06_RS10655	COG3895	Periplasmic Protein
HVY06_RS10670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVY06_RS10675	COG0625	glutathione transferase activity
HVY06_RS10685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVY06_RS10695	COG4659	FMN binding
HVY06_RS10735	COG0673	inositol 2-dehydrogenase activity
HVY06_RS10750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY06_RS10755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS10755	COG1263	PTS System
HVY06_RS10760	COG1609	Transcriptional regulator
HVY06_RS10765	COG5339	Protein conserved in bacteria
HVY06_RS10770	COG1482	cell wall glycoprotein biosynthetic process
HVY06_RS10775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY06_RS10775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY06_RS10790	COG2205	protein histidine kinase activity
HVY06_RS10820	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY06_RS10830	COG0745	RESPONSE REGULATOR receiver
HVY06_RS10835	COG3136	membrane protein required for alginate biosynthesis
HVY06_RS10845	COG0531	amino acid
HVY06_RS10855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVY06_RS10860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVY06_RS10865	COG0628	permease
HVY06_RS10880	COG3591	Belongs to the peptidase S1B family
HVY06_RS10890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HVY06_RS10900	COG2814	Major facilitator Superfamily
HVY06_RS10905	COG0583	DNA-binding transcription factor activity
HVY06_RS10910	COG1940	carbohydrate kinase activity
HVY06_RS10915	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY06_RS10925	COG3381	protein complex oligomerization
HVY06_RS10930	COG3302	dmso reductase anchor subunit
HVY06_RS10935	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS10940	COG0243	molybdopterin cofactor binding
HVY06_RS10955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY06_RS10970	COG4948	Mandelate Racemase Muconate Lactonizing
HVY06_RS10975	COG1063	alcohol dehydrogenase
HVY06_RS10980	COG0477	Major facilitator Superfamily
HVY06_RS10985	COG0246	Mannitol dehydrogenase
HVY06_RS10995	COG1802	Transcriptional regulator
HVY06_RS11000	COG4221	oxidoreductase activity
HVY06_RS11010	COG3706	GGDEF domain
HVY06_RS11020	COG2814	Major facilitator Superfamily
HVY06_RS11025	COG0697	spore germination
HVY06_RS11035	COG4977	sequence-specific DNA binding
HVY06_RS11040	COG1846	Transcriptional regulator
HVY06_RS11055	COG0583	DNA-binding transcription factor activity
HVY06_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS11085	COG3781	membrane
HVY06_RS11135	COG0667	Aldo Keto reductase
HVY06_RS11145	COG5002	protein histidine kinase activity
HVY06_RS11165	COG0656	L-ascorbic acid biosynthetic process
HVY06_RS11185	COG1064	alcohol dehydrogenase
HVY06_RS11200	COG0702	epimerase
HVY06_RS11215	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY06_RS11220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY06_RS11245	COG4628	conserved protein (DUF2132)
HVY06_RS11265	COG1566	PFAM secretion protein HlyD family protein
HVY06_RS11270	COG0840	transmembrane signaling receptor activity
HVY06_RS11285	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HVY06_RS11290	COG0747	negative chemotaxis
HVY06_RS11295	COG0601	transmembrane transport
HVY06_RS11300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY06_RS11305	COG0444	Belongs to the ABC transporter superfamily
HVY06_RS11310	COG4608	Belongs to the ABC transporter superfamily
HVY06_RS11315	COG0583	DNA-binding transcription factor activity
HVY06_RS11320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY06_RS11325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY06_RS11335	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY06_RS11340	COG2610	gluconate transmembrane transporter activity
HVY06_RS11345	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS11350	COG1764	response to oxidative stress
HVY06_RS11365	COG0488	(ABC) transporter
HVY06_RS11375	COG3093	addiction module antidote protein HigA
HVY06_RS11380	COG2864	formate dehydrogenase
HVY06_RS11385	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS11425	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY06_RS11430	COG1140	nitrate reductase beta subunit
HVY06_RS11435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY06_RS11440	COG2181	nitrate reductase activity
HVY06_RS11445	COG0384	phenazine biosynthesis protein PhzF
HVY06_RS11450	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVY06_RS11455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY06_RS11460	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY06_RS11470	COG1609	Transcriptional regulator
HVY06_RS11480	COG2271	Major facilitator Superfamily
HVY06_RS11485	COG1126	abc transporter atp-binding protein
HVY06_RS11505	COG1473	amidohydrolase
HVY06_RS11510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY06_RS11515	COG0840	transmembrane signaling receptor activity
HVY06_RS11535	COG2130	NADP-dependent
HVY06_RS11545	COG1247	-acetyltransferase
HVY06_RS11550	COG3238	Protein conserved in bacteria
HVY06_RS11560	COG0747	negative chemotaxis
HVY06_RS11590	COG1396	sequence-specific DNA binding
HVY06_RS11595	COG0456	acetyltransferase
HVY06_RS11635	COG0583	DNA-binding transcription factor activity
HVY06_RS11645	COG1177	transmembrane transport
HVY06_RS11650	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY06_RS11655	COG3842	ATPase activity
HVY06_RS11660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY06_RS11665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY06_RS11670	COG1271	oxidase subunit
HVY06_RS11675	COG1294	oxidase, subunit
HVY06_RS11690	COG0826	peptidase U32
HVY06_RS11695	COG1396	sequence-specific DNA binding
HVY06_RS11700	COG3135	benzoate transporter
HVY06_RS11710	COG0697	spore germination
HVY06_RS11720	COG0500	methyltransferase
HVY06_RS11725	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVY06_RS11730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY06_RS11735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY06_RS11745	COG2841	Protein conserved in bacteria
HVY06_RS11755	COG5383	Protein conserved in bacteria
HVY06_RS11790	COG1227	inorganic diphosphatase activity
HVY06_RS11795	COG0583	DNA-binding transcription factor activity
HVY06_RS11800	COG0840	transmembrane signaling receptor activity
HVY06_RS11815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVY06_RS11820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVY06_RS11845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HVY06_RS11845	COG3264	Mechanosensitive ion channel
HVY06_RS11850	COG0697	spore germination
HVY06_RS11855	COG3038	cytochrome b561
HVY06_RS11870	COG2814	Major facilitator Superfamily
HVY06_RS11875	COG1869	D-ribose catabolic process
HVY06_RS11880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS11885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HVY06_RS11890	COG2207	Transcriptional regulator
HVY06_RS11900	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS11905	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY06_RS11910	COG1643	Atp-dependent helicase
HVY06_RS11930	COG0671	phosphoesterase, PA-phosphatase related
HVY06_RS11930	COG2453	phosphatase
HVY06_RS11935	COG2267	carboxylic ester hydrolase activity
HVY06_RS11945	COG4589	Belongs to the CDS family
HVY06_RS11950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY06_RS11955	COG3784	Protein of unknown function (DUF1318)
HVY06_RS11965	COG2911	Protein conserved in bacteria
HVY06_RS11980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY06_RS11985	COG3187	Heat shock protein
HVY06_RS11990	COG3042	response to heat
HVY06_RS11995	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVY06_RS11995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY06_RS11995	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVY06_RS11995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVY06_RS12000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY06_RS12020	COG0513	Belongs to the DEAD box helicase family
HVY06_RS12035	COG0840	transmembrane signaling receptor activity
HVY06_RS12045	COG3706	GGDEF domain
HVY06_RS12050	COG2840	Smr protein MutS2
HVY06_RS12075	COG3182	Iron-regulated membrane protein
HVY06_RS12080	COG0668	transmembrane transport
HVY06_RS12085	COG0346	lactoylglutathione lyase activity
HVY06_RS12090	COG1349	DNA-binding transcription factor activity
HVY06_RS12110	COG4166	transmembrane transport
HVY06_RS12115	COG2866	Carboxypeptidase
HVY06_RS12120	COG4948	Mandelate Racemase Muconate Lactonizing
HVY06_RS12125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVY06_RS12140	COG3106	COG3106 Predicted ATPase
HVY06_RS12145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY06_RS12155	COG1983	PspC domain protein
HVY06_RS12165	COG1842	Phage shock protein A
HVY06_RS12170	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY06_RS12185	COG4171	peptide transport system, permease
HVY06_RS12205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVY06_RS12210	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY06_RS12210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY06_RS12220	COG5001	Diguanylate cyclase
HVY06_RS12230	COG1349	DNA-binding transcription factor activity
HVY06_RS12240	COG0023	Translation Initiation Factor
HVY06_RS12250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVY06_RS12255	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVY06_RS12260	COG0671	phosphoesterase, PA-phosphatase related
HVY06_RS12270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY06_RS12300	COG0616	signal peptide processing
HVY06_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS12320	COG0009	L-threonylcarbamoyladenylate synthase
HVY06_RS12330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY06_RS12355	COG3706	GGDEF domain
HVY06_RS12370	COG3047	cAMP biosynthetic process
HVY06_RS12395	COG2350	Protein conserved in bacteria
HVY06_RS12420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY06_RS12430	COG0444	Belongs to the ABC transporter superfamily
HVY06_RS12450	COG2095	MarC family integral membrane protein
HVY06_RS12455	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS12455	COG1454	alcohol dehydrogenase
HVY06_RS12460	COG1435	thymidine kinase activity
HVY06_RS12470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY06_RS12475	COG0745	RESPONSE REGULATOR receiver
HVY06_RS12480	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVY06_RS12490	COG0788	formyltetrahydrofolate deformylase activity
HVY06_RS12515	COG2181	nitrate reductase activity
HVY06_RS12520	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY06_RS12525	COG1140	nitrate reductase beta subunit
HVY06_RS12530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY06_RS12535	COG2223	nitrite transmembrane transporter activity
HVY06_RS12540	COG3850	Histidine kinase
HVY06_RS12545	COG2197	response regulator
HVY06_RS12550	COG4932	domain protein
HVY06_RS12555	COG0243	molybdopterin cofactor binding
HVY06_RS12560	COG2146	nitrite reductase [NAD(P)H] activity
HVY06_RS12560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY06_RS12565	COG1116	anion transmembrane transporter activity
HVY06_RS12570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY06_RS12575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY06_RS12580	COG3707	response regulator
HVY06_RS12585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVY06_RS12595	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVY06_RS12600	COG0387	Pfam Sodium calcium exchanger
HVY06_RS12615	COG3094	Invasion gene expression up-regulator, SirB
HVY06_RS12620	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY06_RS12650	COG0659	secondary active sulfate transmembrane transporter activity
HVY06_RS12665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY06_RS12670	COG1120	ATPase activity
HVY06_RS12685	COG2857	Cytochrome c1
HVY06_RS12685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HVY06_RS12705	COG0012	GTP binding
HVY06_RS12710	COG0217	transcriptional regulatory protein
HVY06_RS12715	COG1902	pentaerythritol trinitrate reductase activity
HVY06_RS12720	COG0583	DNA-binding transcription factor activity
HVY06_RS12725	COG5002	protein histidine kinase activity
HVY06_RS12730	COG0745	RESPONSE REGULATOR receiver
HVY06_RS12755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVY06_RS12760	COG2376	Dihydroxyacetone kinase
HVY06_RS12765	COG1461	Dihydroxyacetone kinase
HVY06_RS12770	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HVY06_RS12770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS12770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY06_RS12795	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVY06_RS12805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY06_RS12815	COG2719	SpoVR family
HVY06_RS12845	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY06_RS12860	COG2894	cell division
HVY06_RS12870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVY06_RS12875	COG0318	PFAM AMP-dependent synthetase and ligase
HVY06_RS12880	COG3065	identical protein binding
HVY06_RS12885	COG1214	PFAM Peptidase M22, glycoprotease
HVY06_RS12890	COG1199	ATP-dependent helicase activity
HVY06_RS12895	COG0251	oxidation-reduction process
HVY06_RS12915	COG1760	l-serine dehydratase
HVY06_RS12920	COG2200	EAL domain
HVY06_RS12925	COG1253	flavin adenine dinucleotide binding
HVY06_RS12930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS12930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS12935	COG3715	PTS system
HVY06_RS12940	COG3716	PTS system mannose fructose sorbose family IID component
HVY06_RS12955	COG2226	methyltransferase
HVY06_RS12960	COG0768	penicillin binding
HVY06_RS12990	COG1414	Transcriptional regulator
HVY06_RS12995	COG2814	Major facilitator Superfamily
HVY06_RS13015	COG1956	GAF domain-containing protein
HVY06_RS13020	COG2995	paraquat-inducible protein a
HVY06_RS13025	COG3008	intermembrane lipid transfer
HVY06_RS13055	COG1276	copper resistance
HVY06_RS13060	COG2372	response to copper ion
HVY06_RS13070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY06_RS13075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY06_RS13080	COG1770	oligopeptidase
HVY06_RS13085	COG2979	Protein of unknown function (DUF533)
HVY06_RS13095	COG3141	response to X-ray
HVY06_RS13110	COG0534	Mate efflux family protein
HVY06_RS13120	COG0583	DNA-binding transcription factor activity
HVY06_RS13135	COG1840	ABC-type Fe3 transport system, periplasmic component
HVY06_RS13140	COG1178	ABC-type Fe3 transport system permease component
HVY06_RS13150	COG1376	ErfK ybiS ycfS ynhG family protein
HVY06_RS13330	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS13340	COG4656	Part of a membrane complex involved in electron transport
HVY06_RS13375	COG1289	transmembrane transporter activity
HVY06_RS13405	COG2925	Exonuclease
HVY06_RS13410	COG0531	amino acid
HVY06_RS13420	COG0583	DNA-binding transcription factor activity
HVY06_RS13425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY06_RS13440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVY06_RS13570	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY06_RS13590	COG2327	Polysaccharide pyruvyl transferase
HVY06_RS13595	COG2244	polysaccharide biosynthetic process
HVY06_RS13600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY06_RS13605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY06_RS13615	COG0297	glycogen (starch) synthase activity
HVY06_RS13620	COG1051	belongs to the nudix hydrolase family
HVY06_RS13625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY06_RS13630	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVY06_RS13635	COG0110	maltose O-acetyltransferase activity
HVY06_RS13640	COG1216	Glycosyl transferase, family 2
HVY06_RS13650	COG0438	transferase activity, transferring glycosyl groups
HVY06_RS13655	COG1045	serine acetyltransferase
HVY06_RS13660	COG0463	Glycosyl transferase, family 2
HVY06_RS13680	COG1253	flavin adenine dinucleotide binding
HVY06_RS13685	COG2982	Protein involved in outer membrane biogenesis
HVY06_RS13700	COG3447	MASE1 domain protein
HVY06_RS13700	COG5002	protein histidine kinase activity
HVY06_RS13700	COG5001	Diguanylate cyclase
HVY06_RS13705	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVY06_RS13710	COG0443	Heat shock 70 kDa protein
HVY06_RS13740	COG2205	protein histidine kinase activity
HVY06_RS13745	COG0745	RESPONSE REGULATOR receiver
HVY06_RS13765	COG0542	response to heat
HVY06_RS13775	COG1278	Cold shock
HVY06_RS13785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY06_RS13790	COG2990	Protein conserved in bacteria
HVY06_RS13795	COG3593	DNA synthesis involved in DNA repair
HVY06_RS13805	COG2431	L-lysine efflux transmembrane transporter activity
HVY06_RS13815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY06_RS13830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HVY06_RS13850	COG4529	Protein conserved in bacteria
HVY06_RS13860	COG0028	Belongs to the TPP enzyme family
HVY06_RS13865	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVY06_RS13870	COG0702	epimerase
HVY06_RS13875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY06_RS13880	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY06_RS13915	COG1126	abc transporter atp-binding protein
HVY06_RS13920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY06_RS13925	COG4215	(ABC) transporter
HVY06_RS13930	COG4160	amino acid transport
HVY06_RS13935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY06_RS13945	COG4608	Belongs to the ABC transporter superfamily
HVY06_RS13950	COG0444	Belongs to the ABC transporter superfamily
HVY06_RS13960	COG0601	transmembrane transport
HVY06_RS13965	COG0747	negative chemotaxis
HVY06_RS13970	COG4948	Mandelate Racemase Muconate Lactonizing
HVY06_RS13975	COG1830	Aldolase
HVY06_RS13980	COG2211	Major facilitator Superfamily
HVY06_RS13985	COG1397	ADP-ribosylglycohydrolase
HVY06_RS13990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS13995	COG2188	Transcriptional regulator
HVY06_RS14000	COG0351	phosphomethylpyrimidine kinase
HVY06_RS14020	COG5455	response to cobalt ion
HVY06_RS14030	COG3188	usher protein
HVY06_RS14035	COG3121	Chaperone
HVY06_RS14060	COG4807	Protein conserved in bacteria
HVY06_RS14070	COG3275	phosphorelay sensor kinase activity
HVY06_RS14075	COG0789	Transcriptional regulator
HVY06_RS14085	COG1174	glycine betaine transport
HVY06_RS14090	COG1125	glycine betaine transport
HVY06_RS14095	COG1174	glycine betaine transport
HVY06_RS14100	COG1732	Glycine betaine
HVY06_RS14105	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY06_RS14110	COG0277	FAD linked oxidase domain protein
HVY06_RS14115	COG1686	Belongs to the peptidase S11 family
HVY06_RS14125	COG0586	Pfam SNARE associated Golgi protein
HVY06_RS14135	COG2226	methyltransferase
HVY06_RS14145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY06_RS14155	COG1346	cytolysis
HVY06_RS14165	COG2949	membrane
HVY06_RS14190	COG1129	ABC transporter
HVY06_RS14205	COG2311	Membrane
HVY06_RS14220	COG4771	TonB-dependent receptor
HVY06_RS14225	COG0833	amino acid
HVY06_RS14230	COG0583	DNA-binding transcription factor activity
HVY06_RS14235	COG2855	membrane
HVY06_RS14245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY06_RS14245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY06_RS14245	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVY06_RS14250	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY06_RS14255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS14255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS14275	COG3381	protein complex oligomerization
HVY06_RS14285	COG3005	denitrification pathway
HVY06_RS14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY06_RS14295	COG1312	Catalyzes the dehydration of D-mannonate
HVY06_RS14300	COG0246	Mannitol dehydrogenase
HVY06_RS14305	COG0523	cobalamin synthesis protein
HVY06_RS14310	COG0671	phosphoesterase, PA-phosphatase related
HVY06_RS14315	COG0791	NLP P60 protein
HVY06_RS14320	COG2200	EAL domain
HVY06_RS14325	COG4166	transmembrane transport
HVY06_RS14330	COG4174	ABC transporter (Permease)
HVY06_RS14335	COG4239	(ABC) transporter, permease
HVY06_RS14340	COG4172	Belongs to the ABC transporter superfamily
HVY06_RS14350	COG2814	Major facilitator Superfamily
HVY06_RS14355	COG1187	pseudouridine synthase activity
HVY06_RS14360	COG1061	Type III restriction enzyme res subunit
HVY06_RS14400	COG2197	response regulator
HVY06_RS14405	COG3088	subunit of a heme lyase
HVY06_RS14405	COG4235	cytochrome complex assembly
HVY06_RS14410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY06_RS14415	COG1138	Cytochrome C-type biogenesis protein
HVY06_RS14425	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY06_RS14430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY06_RS14440	COG4133	protoheme IX ABC transporter activity
HVY06_RS14445	COG3005	denitrification pathway
HVY06_RS14450	COG3043	anaerobic respiration
HVY06_RS14455	COG0348	domain, Protein
HVY06_RS14460	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS14470	COG3062	negative regulation of establishment of protein localization
HVY06_RS14475	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY06_RS14475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY06_RS14490	COG0659	secondary active sulfate transmembrane transporter activity
HVY06_RS14495	COG2239	Acts as a magnesium transporter
HVY06_RS14500	COG4615	Cyclic peptide transporter
HVY06_RS14505	COG3145	DNA-N1-methyladenine dioxygenase activity
HVY06_RS14510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY06_RS14510	COG2169	Transcriptional regulator
HVY06_RS14520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY06_RS14525	COG2198	Histidine kinase
HVY06_RS14525	COG0642	Histidine kinase
HVY06_RS14530	COG2197	response regulator
HVY06_RS14540	COG3852	Histidine kinase
HVY06_RS14545	COG2204	response regulator
HVY06_RS14550	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY06_RS14555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY06_RS14560	COG2031	fatty acid transporter
HVY06_RS14565	COG0183	Belongs to the thiolase family
HVY06_RS14590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY06_RS14600	COG0583	DNA-binding transcription factor activity
HVY06_RS14605	COG0584	glycerophosphoryl diester phosphodiesterase
HVY06_RS14610	COG2271	Major facilitator Superfamily
HVY06_RS14615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY06_RS14625	COG0247	lactate metabolic process
HVY06_RS14705	COG1169	isochorismate synthase
HVY06_RS14710	COG4575	ribosome binding
HVY06_RS14715	COG2153	protein acetylation
HVY06_RS14725	COG0784	Response regulator, receiver
HVY06_RS14725	COG0835	chemotaxis
HVY06_RS14735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY06_RS14740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY06_RS14750	COG0839	Belongs to the complex I subunit 6 family
HVY06_RS14770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVY06_RS14775	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVY06_RS14795	COG0583	DNA-binding transcription factor activity
HVY06_RS14800	COG0436	Aminotransferase
HVY06_RS14810	COG0490	domain, Protein
HVY06_RS14810	COG0471	metal ion transport
HVY06_RS14815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY06_RS14840	COG1288	antiporter activity
HVY06_RS14850	COG0622	Phosphoesterase
HVY06_RS14855	COG0625	glutathione transferase activity
HVY06_RS14860	COG0625	glutathione transferase activity
HVY06_RS14865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY06_RS14870	COG1090	epimerase
HVY06_RS14875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY06_RS14880	COG4598	ABC transporter
HVY06_RS14895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY06_RS14905	COG0163	prenyltransferase activity
HVY06_RS14910	COG1609	Transcriptional regulator
HVY06_RS14915	COG2211	Major facilitator Superfamily
HVY06_RS14925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVY06_RS14930	COG1286	toxin biosynthetic process
HVY06_RS14935	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVY06_RS14940	COG0285	dihydrofolate synthase activity
HVY06_RS14950	COG0586	Pfam SNARE associated Golgi protein
HVY06_RS14960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY06_RS14980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY06_RS14995	COG3101	peptidyl-lysine hydroxylation
HVY06_RS15000	COG0730	response to heat
HVY06_RS15025	COG2062	phosphohistidine phosphatase, SixA
HVY06_RS15040	COG3691	Protein conserved in bacteria
HVY06_RS15045	COG2067	long-chain fatty acid transport protein
HVY06_RS15055	COG2116	formate transmembrane transporter activity
HVY06_RS15065	COG3122	Protein conserved in bacteria
HVY06_RS15095	COG1560	Kdo2-lipid A biosynthetic process
HVY06_RS15110	COG0436	Aminotransferase
HVY06_RS15115	COG3275	phosphorelay sensor kinase activity
HVY06_RS15120	COG3279	Response regulator of the LytR AlgR family
HVY06_RS15140	COG3961	Belongs to the TPP enzyme family
HVY06_RS15145	COG0667	Aldo Keto reductase
HVY06_RS15160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY06_RS15175	COG3415	Transposase
HVY06_RS15180	COG3415	Transposase
HVY06_RS15215	COG0583	DNA-binding transcription factor activity
HVY06_RS15220	COG2211	Major facilitator Superfamily
HVY06_RS15225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVY06_RS15230	COG0583	DNA-binding transcription factor activity
HVY06_RS15235	COG0385	Bile acid
HVY06_RS15240	COG3530	Putative quorum-sensing-regulated virulence factor
HVY06_RS15305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVY06_RS15310	COG4208	sulfate ABC transporter
HVY06_RS15315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVY06_RS15320	COG4150	thiosulfate binding
HVY06_RS15330	COG2837	iron assimilation
HVY06_RS15350	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY06_RS15360	COG2207	Transcriptional regulator
HVY06_RS15365	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVY06_RS15385	COG4819	ethanolamine utilization protein
HVY06_RS15420	COG0280	phosphate acetyltransferase
HVY06_RS15425	COG4812	Cobalamin adenosyltransferase
HVY06_RS15445	COG3501	Rhs element vgr protein
HVY06_RS15450	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVY06_RS15450	COG1388	LysM domain
HVY06_RS15465	COG3501	Rhs element vgr protein
HVY06_RS15490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY06_RS15495	COG5342	invasion associated locus B
HVY06_RS15505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY06_RS15505	COG0493	'glutamate synthase
HVY06_RS15510	COG3850	Histidine kinase
HVY06_RS15515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY06_RS15525	COG1393	Belongs to the ArsC family
HVY06_RS15540	COG0400	carboxylic ester hydrolase activity
HVY06_RS15550	COG2321	neutral zinc metallopeptidase
HVY06_RS15560	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVY06_RS15570	COG2716	regulation of RNA biosynthetic process
HVY06_RS15575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVY06_RS15580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY06_RS15585	COG0700	Nucleoside recognition
HVY06_RS15590	COG3366	ferrous iron transmembrane transporter activity
HVY06_RS15595	COG0628	permease
HVY06_RS15600	COG4783	chaperone-mediated protein folding
HVY06_RS15605	COG1393	Belongs to the ArsC family
HVY06_RS15615	COG2233	PERMEase
HVY06_RS15625	COG2723	6-phospho-beta-galactosidase activity
HVY06_RS15640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVY06_RS15655	COG2200	EAL domain
HVY06_RS15665	COG0668	transmembrane transport
HVY06_RS15675	COG0517	IMP dehydrogenase activity
HVY06_RS15675	COG0516	GMP reductase activity
HVY06_RS15695	COG1470	cell adhesion involved in biofilm formation
HVY06_RS15695	COG1388	LysM domain
HVY06_RS15700	COG1645	bacterial-type flagellum-dependent swarming motility
HVY06_RS15705	COG3104	oligopeptide transport
HVY06_RS15720	COG2976	Protein conserved in bacteria
HVY06_RS15740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HVY06_RS15745	COG0105	UTP biosynthetic process
HVY06_RS15750	COG4953	penicillin-binding protein 1C
HVY06_RS15755	COG2373	Large extracellular alpha-helical protein
HVY06_RS15760	COG2897	thiosulfate sulfurtransferase activity
HVY06_RS15775	COG2975	iron-sulfur cluster assembly
HVY06_RS15780	COG0633	Ferredoxin
HVY06_RS15800	COG0822	iron-sulfur transferase activity
HVY06_RS15805	COG1104	cysteine desulfurase activity
HVY06_RS15825	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY06_RS15830	COG3683	transport system, periplasmic component
HVY06_RS15840	COG1129	ABC transporter
HVY06_RS15845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS15855	COG1069	ribulokinase activity
HVY06_RS15860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY06_RS15860	COG0517	IMP dehydrogenase activity
HVY06_RS15865	COG3711	transcriptional antiterminator
HVY06_RS15870	COG2814	Major facilitator Superfamily
HVY06_RS15880	COG2814	Major facilitator Superfamily
HVY06_RS15880	COG0477	Major facilitator Superfamily
HVY06_RS15885	COG0457	Tetratricopeptide repeat
HVY06_RS15890	COG1940	carbohydrate kinase activity
HVY06_RS15895	COG0583	DNA-binding transcription factor activity
HVY06_RS15900	COG4638	Rieske (2fe-2S)
HVY06_RS15930	COG1017	nitric oxide dioxygenase activity
HVY06_RS15930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY06_RS15935	COG0347	Belongs to the P(II) protein family
HVY06_RS15940	COG2204	response regulator
HVY06_RS15945	COG3170	Tfp pilus assembly protein FimV
HVY06_RS15950	COG2205	protein histidine kinase activity
HVY06_RS15970	COG0560	Phosphoserine phosphatase
HVY06_RS15975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS15975	COG1263	PTS System
HVY06_RS15980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HVY06_RS15985	COG1737	Transcriptional regulator
HVY06_RS15990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY06_RS16000	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVY06_RS16020	COG0681	Belongs to the peptidase S26 family
HVY06_RS16030	COG3086	response to oxidative stress
HVY06_RS16035	COG3026	antisigma factor binding
HVY06_RS16045	COG1595	DNA-templated transcription, initiation
HVY06_RS16055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY06_RS16065	COG0513	Belongs to the DEAD box helicase family
HVY06_RS16080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY06_RS16085	COG3118	belongs to the thioredoxin family
HVY06_RS16100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY06_RS16105	COG5544	Lipoprotein
HVY06_RS16110	COG0477	Major facilitator Superfamily
HVY06_RS16135	COG0542	response to heat
HVY06_RS16150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY06_RS16155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY06_RS16165	COG0077	Prephenate dehydratase
HVY06_RS16165	COG1605	Chorismate mutase
HVY06_RS16170	COG0287	Prephenate dehydrogenase
HVY06_RS16170	COG1605	Chorismate mutase
HVY06_RS16175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY06_RS16190	COG2199	diguanylate cyclase activity
HVY06_RS16195	COG2885	chlorophyll binding
HVY06_RS16230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVY06_RS16235	COG4137	Cytochrome C assembly protein
HVY06_RS16240	COG4536	flavin adenine dinucleotide binding
HVY06_RS16255	COG0497	DNA recombination
HVY06_RS16260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY06_RS16270	COG2867	negative regulation of translational initiation
HVY06_RS16295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY06_RS16305	COG0582	viral genome integration into host DNA
HVY06_RS16410	COG0582	viral genome integration into host DNA
HVY06_RS16470	COG3718	enzyme involved in inositol metabolism
HVY06_RS16480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS16485	COG0673	inositol 2-dehydrogenase activity
HVY06_RS16490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS16505	COG0673	inositol 2-dehydrogenase activity
HVY06_RS16510	COG3962	Belongs to the TPP enzyme family
HVY06_RS16535	COG1940	carbohydrate kinase activity
HVY06_RS16535	COG1846	Transcriptional regulator
HVY06_RS16540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY06_RS16550	COG0477	Major facilitator Superfamily
HVY06_RS16555	COG2271	Major facilitator Superfamily
HVY06_RS16560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVY06_RS16565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY06_RS16570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY06_RS16590	COG2169	Transcriptional regulator
HVY06_RS16595	COG1757	Na H antiporter
HVY06_RS16600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY06_RS16630	COG0297	glycogen (starch) synthase activity
HVY06_RS16630	COG0438	transferase activity, transferring glycosyl groups
HVY06_RS16635	COG0297	glycogen (starch) synthase activity
HVY06_RS16670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY06_RS16675	COG0642	Histidine kinase
HVY06_RS16700	COG0583	DNA-binding transcription factor activity
HVY06_RS16715	COG0579	oxidoreductase
HVY06_RS16720	COG1012	belongs to the aldehyde dehydrogenase family
HVY06_RS16725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY06_RS16730	COG1113	amino acid transport
HVY06_RS16735	COG1802	Transcriptional regulator
HVY06_RS16740	COG0401	homolog of Blt101
HVY06_RS16745	COG0640	Transcriptional regulator
HVY06_RS16750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY06_RS16780	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY06_RS16795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY06_RS16800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY06_RS16810	COG4176	ABC-type proline glycine betaine transport system permease component
HVY06_RS16820	COG2814	Major facilitator Superfamily
HVY06_RS16825	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY06_RS16835	COG1846	Transcriptional regulator
HVY06_RS16840	COG1566	PFAM secretion protein HlyD family protein
HVY06_RS16845	COG2814	Major facilitator Superfamily
HVY06_RS16850	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY06_RS16860	COG2211	Major facilitator Superfamily
HVY06_RS16875	COG1238	metal cluster binding
HVY06_RS16880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY06_RS16910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVY06_RS16930	COG1546	Belongs to the CinA family
HVY06_RS16935	COG2951	lytic endotransglycosylase activity
HVY06_RS16940	COG3730	PTS system glucitol sorbitol-specific
HVY06_RS16945	COG3732	PTS system glucitol sorbitol-specific
HVY06_RS16955	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS16960	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS16965	COG1349	DNA-binding transcription factor activity
HVY06_RS16970	COG0517	IMP dehydrogenase activity
HVY06_RS16970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY06_RS16990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVY06_RS16995	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY06_RS17000	COG1609	Transcriptional regulator
HVY06_RS17005	COG1263	PTS System
HVY06_RS17005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS17010	COG2723	6-phospho-beta-galactosidase activity
HVY06_RS17020	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY06_RS17030	COG3260	NADH ubiquinone oxidoreductase 20
HVY06_RS17035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY06_RS17040	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY06_RS17040	COG3261	NADH dehydrogenase
HVY06_RS17045	COG0650	Formate hydrogenlyase subunit 4
HVY06_RS17050	COG0651	ATP synthesis coupled electron transport
HVY06_RS17055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY06_RS17070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY06_RS17075	COG0298	carbon dioxide binding
HVY06_RS17080	COG0409	Hydrogenase expression formation protein
HVY06_RS17085	COG0309	Hydrogenase expression formation protein (HypE)
HVY06_RS17105	COG1121	(ABC) transporter
HVY06_RS17110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY06_RS17115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY06_RS17145	COG0745	RESPONSE REGULATOR receiver
HVY06_RS17155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVY06_RS17160	COG2201	protein-glutamate methylesterase activity
HVY06_RS17170	COG2200	EAL domain
HVY06_RS17175	COG3300	MHYT domain
HVY06_RS17175	COG5001	Diguanylate cyclase
HVY06_RS17250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY06_RS17255	COG0163	prenyltransferase activity
HVY06_RS17270	COG1388	LysM domain
HVY06_RS17270	COG4942	peptidase
HVY06_RS17290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HVY06_RS17325	COG2234	aminopeptidase activity
HVY06_RS17340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HVY06_RS17345	COG0720	synthase
HVY06_RS17350	COG0602	queuosine metabolic process
HVY06_RS17355	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HVY06_RS17360	COG2190	(PTS) system
HVY06_RS17360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS17360	COG1263	PTS System
HVY06_RS17365	COG1737	Transcriptional regulator
HVY06_RS17395	COG3956	TIGRFAM MazG family protein
HVY06_RS17400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY06_RS17410	COG4999	Histidine kinase
HVY06_RS17410	COG3437	response regulator, receiver
HVY06_RS17410	COG2205	protein histidine kinase activity
HVY06_RS17410	COG3850	Histidine kinase
HVY06_RS17415	COG1929	Belongs to the glycerate kinase type-1 family
HVY06_RS17420	COG4948	Mandelate Racemase Muconate Lactonizing
HVY06_RS17425	COG4948	Mandelate Racemase Muconate Lactonizing
HVY06_RS17430	COG2271	Major facilitator Superfamily
HVY06_RS17435	COG0716	FMN binding
HVY06_RS17440	COG0564	pseudouridine synthase activity
HVY06_RS17445	COG3098	single-species biofilm formation
HVY06_RS17460	COG1611	Belongs to the LOG family
HVY06_RS17465	COG0814	amino acid
HVY06_RS17470	COG1760	l-serine dehydratase
HVY06_RS17480	COG1454	alcohol dehydrogenase
HVY06_RS17485	COG0235	Class ii aldolase
HVY06_RS17495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HVY06_RS17505	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS17510	COG1129	ABC transporter
HVY06_RS17520	COG1070	Carbohydrate kinase
HVY06_RS17530	COG1349	DNA-binding transcription factor activity
HVY06_RS17540	COG2363	Small membrane protein
HVY06_RS17545	COG0583	DNA-binding transcription factor activity
HVY06_RS17555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVY06_RS17560	COG2166	iron-sulfur cluster assembly
HVY06_RS17565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVY06_RS17570	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVY06_RS17590	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY06_RS17595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVY06_RS17595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVY06_RS17600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY06_RS17605	COG1074	ATP-dependent DNA helicase activity
HVY06_RS17615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVY06_RS17620	COG4967	type IV pilus modification protein PilV
HVY06_RS17630	COG4795	General secretion pathway protein
HVY06_RS17635	COG2165	general secretion pathway protein
HVY06_RS17665	COG0861	Integral membrane protein TerC family
HVY06_RS17675	COG0667	Aldo Keto reductase
HVY06_RS17690	COG1609	Transcriptional regulator
HVY06_RS17695	COG1609	Transcriptional regulator
HVY06_RS17705	COG0583	DNA-binding transcription factor activity
HVY06_RS17710	COG1794	racemase activity, acting on amino acids and derivatives
HVY06_RS17720	COG1175	transmembrane transport
HVY06_RS17725	COG0395	ABC-type sugar transport system, permease component
HVY06_RS17730	COG3842	ATPase activity
HVY06_RS17740	COG2814	Major facilitator Superfamily
HVY06_RS17745	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS17755	COG0823	Involved in the tonB-independent uptake of proteins
HVY06_RS17760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVY06_RS17765	COG0183	Belongs to the thiolase family
HVY06_RS17780	COG0814	amino acid
HVY06_RS17795	COG0402	S-adenosylhomocysteine deaminase activity
HVY06_RS17800	COG0549	Belongs to the carbamate kinase family
HVY06_RS17810	COG1304	FMN binding
HVY06_RS17815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY06_RS17825	COG0666	response to abiotic stimulus
HVY06_RS17830	COG0583	DNA-binding transcription factor activity
HVY06_RS17835	COG2388	GCN5-related N-acetyl-transferase
HVY06_RS17840	COG3592	Divergent 4Fe-4S mono-cluster
HVY06_RS17850	COG1215	transferase activity, transferring glycosyl groups
HVY06_RS17855	COG0726	polysaccharide deacetylase
HVY06_RS17855	COG1649	PFAM Uncharacterised BCR, COG1649
HVY06_RS17860	COG0457	Tetratricopeptide repeat
HVY06_RS17865	COG1470	cell adhesion involved in biofilm formation
HVY06_RS17865	COG1388	LysM domain
HVY06_RS17920	COG1196	nuclear chromosome segregation
HVY06_RS18005	COG0582	viral genome integration into host DNA
HVY06_RS18015	COG4942	peptidase
HVY06_RS18035	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVY06_RS18060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVY06_RS18070	COG1272	protein, Hemolysin III
HVY06_RS18080	COG1737	Transcriptional regulator
HVY06_RS18085	COG2723	6-phospho-beta-galactosidase activity
HVY06_RS18090	COG1028	Short-chain dehydrogenase reductase Sdr
HVY06_RS18110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY06_RS18115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY06_RS18120	COG0006	proline dipeptidase activity
HVY06_RS18140	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVY06_RS18145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY06_RS18160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY06_RS18160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY06_RS18165	COG1703	isobutyryl-CoA mutase activity
HVY06_RS18170	COG1024	Enoyl-CoA hydratase
HVY06_RS18175	COG0427	acetyl-CoA hydrolase
HVY06_RS18180	COG0583	DNA-binding transcription factor activity
HVY06_RS18185	COG2968	Membrane
HVY06_RS18190	COG1279	arginine transmembrane transporter activity
HVY06_RS18195	COG0668	transmembrane transport
HVY06_RS18200	COG0191	fructose-bisphosphate aldolase activity
HVY06_RS18230	COG1122	ATPase activity
HVY06_RS18235	COG1122	ATPase activity
HVY06_RS18240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY06_RS18245	COG0501	Belongs to the peptidase M48B family
HVY06_RS18255	COG1166	arginine decarboxylase activity
HVY06_RS18280	COG2814	Major facilitator Superfamily
HVY06_RS18290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY06_RS18295	COG2356	endonuclease I
HVY06_RS18300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVY06_RS18305	COG0189	ligase activity
HVY06_RS18320	COG2805	Type II/IV secretion system protein
HVY06_RS18325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVY06_RS18330	COG0762	integral membrane protein
HVY06_RS18345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY06_RS18350	COG0252	asparaginase activity
HVY06_RS18360	COG3171	Protein conserved in bacteria
HVY06_RS18370	COG1194	a g-specific adenine glycosylase
HVY06_RS18385	COG2211	Major facilitator Superfamily
HVY06_RS18390	COG1982	Orn Lys Arg decarboxylase major
HVY06_RS18395	COG1811	Na channel or pump
HVY06_RS18415	COG3157	Type VI secretion system effector, Hcp
HVY06_RS18510	COG3501	Rhs element vgr protein
HVY06_RS18600	COG0754	glutathionylspermidine amidase activity
HVY06_RS18605	COG0243	molybdopterin cofactor binding
HVY06_RS18610	COG0625	glutathione transferase activity
HVY06_RS18615	COG0298	carbon dioxide binding
HVY06_RS18625	COG1773	rubredoxin
HVY06_RS18630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY06_RS18635	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY06_RS18640	COG5557	Pfam Polysulphide reductase, NrfD
HVY06_RS18645	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS18650	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY06_RS18660	COG0840	transmembrane signaling receptor activity
HVY06_RS18665	COG0667	Aldo Keto reductase
HVY06_RS18690	COG0848	biopolymer transport protein
HVY06_RS18700	COG0626	cystathionine gamma-synthase activity
HVY06_RS18705	COG0586	Pfam SNARE associated Golgi protein
HVY06_RS18710	COG2207	Transcriptional regulator
HVY06_RS18715	COG1979	alcohol dehydrogenase
HVY06_RS18720	COG0656	L-ascorbic acid biosynthetic process
HVY06_RS18725	COG0471	metal ion transport
HVY06_RS18730	COG1032	radical SAM domain protein
HVY06_RS18735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY06_RS18755	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY06_RS18770	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY06_RS18775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVY06_RS18780	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HVY06_RS18785	COG2211	Major facilitator Superfamily
HVY06_RS18800	COG0187	DNA topoisomerase II activity
HVY06_RS18805	COG3150	esterase
HVY06_RS18810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY06_RS18815	COG3151	Protein conserved in bacteria
HVY06_RS18820	COG0494	nUDIX hydrolase
HVY06_RS18825	COG1538	Outer membrane efflux protein
HVY06_RS18835	COG0754	glutathionylspermidine amidase activity
HVY06_RS18840	COG3384	dioxygenase
HVY06_RS18870	COG2268	Band 7 protein
HVY06_RS18885	COG3025	triphosphatase activity
HVY06_RS18890	COG4991	sh3 domain protein
HVY06_RS18905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY06_RS18925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY06_RS18930	COG0471	metal ion transport
HVY06_RS18935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HVY06_RS18940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVY06_RS18945	COG0358	DNA primase activity
HVY06_RS18975	COG0583	DNA-binding transcription factor activity
HVY06_RS19040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY06_RS19050	COG2375	cellular response to nickel ion
HVY06_RS19055	COG1695	Transcriptional regulator
HVY06_RS19060	COG0840	transmembrane signaling receptor activity
HVY06_RS19070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVY06_RS19075	COG1609	Transcriptional regulator
HVY06_RS19080	COG3250	beta-galactosidase activity
HVY06_RS19085	COG2731	YhcH YjgK YiaL family protein
HVY06_RS19090	COG0531	amino acid
HVY06_RS19100	COG3408	Glycogen debranching enzyme
HVY06_RS19100	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVY06_RS19105	COG1902	pentaerythritol trinitrate reductase activity
HVY06_RS19105	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVY06_RS19115	COG1451	nucleotide metabolic process
HVY06_RS19120	COG0673	inositol 2-dehydrogenase activity
HVY06_RS19140	COG2721	sulfolactate sulfo-lyase activity
HVY06_RS19150	COG2271	Major facilitator Superfamily
HVY06_RS19155	COG2186	Transcriptional regulator
HVY06_RS19160	COG0586	Pfam SNARE associated Golgi protein
HVY06_RS19170	COG1422	Protein of unknown function (DUF1090)
HVY06_RS19175	COG4575	ribosome binding
HVY06_RS19180	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVY06_RS19190	COG2259	Doxx family
HVY06_RS19195	COG0435	Glutathione S-transferase
HVY06_RS19200	COG3152	Membrane
HVY06_RS19205	COG0583	DNA-binding transcription factor activity
HVY06_RS19210	COG1741	Belongs to the pirin family
HVY06_RS19225	COG0814	amino acid
HVY06_RS19230	COG1760	l-serine dehydratase
HVY06_RS19235	COG0251	oxidation-reduction process
HVY06_RS19240	COG1882	Formate acetyltransferase
HVY06_RS19260	COG0583	DNA-binding transcription factor activity
HVY06_RS19270	COG1929	Belongs to the glycerate kinase type-1 family
HVY06_RS19275	COG2084	Dehydrogenase
HVY06_RS19285	COG2271	Major facilitator Superfamily
HVY06_RS19290	COG2721	sulfolactate sulfo-lyase activity
HVY06_RS19300	COG1175	transmembrane transport
HVY06_RS19305	COG0395	ABC-type sugar transport system, permease component
HVY06_RS19310	COG3842	ATPase activity
HVY06_RS19315	COG0673	inositol 2-dehydrogenase activity
HVY06_RS19320	COG1940	carbohydrate kinase activity
HVY06_RS19325	COG1349	DNA-binding transcription factor activity
HVY06_RS19330	COG1349	DNA-binding transcription factor activity
HVY06_RS19340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY06_RS19350	COG3716	PTS system mannose fructose sorbose family IID component
HVY06_RS19355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS19360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY06_RS19365	COG2222	sugar isomerase
HVY06_RS19375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVY06_RS19395	COG2823	Periplasmic or secreted lipoprotein
HVY06_RS19400	COG0702	epimerase
HVY06_RS19415	COG3153	acetyltransferase
HVY06_RS19420	COG3154	lipid carrier protein
HVY06_RS19425	COG0826	peptidase U32
HVY06_RS19430	COG0826	peptidase U32
HVY06_RS19435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY06_RS19440	COG0814	amino acid
HVY06_RS19445	COG0513	Belongs to the DEAD box helicase family
HVY06_RS19475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HVY06_RS19480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HVY06_RS19485	COG0195	Participates in both transcription termination and antitermination
HVY06_RS19510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY06_RS19515	COG0583	DNA-binding transcription factor activity
HVY06_RS19520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY06_RS19525	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY06_RS19535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVY06_RS19540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVY06_RS19550	COG1534	Rna-binding protein
HVY06_RS19560	COG2027	D-alanyl-D-alanine carboxypeptidase
HVY06_RS19565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HVY06_RS19570	COG0697	spore germination
HVY06_RS19575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HVY06_RS19580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HVY06_RS19585	COG0142	geranyltranstransferase activity
HVY06_RS19590	COG3423	Transcriptional regulator
HVY06_RS19600	COG5007	Belongs to the BolA IbaG family
HVY06_RS19605	COG3113	response to antibiotic
HVY06_RS19610	COG2854	intermembrane phospholipid transfer
HVY06_RS19615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY06_RS19620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVY06_RS19625	COG1127	ABC transporter
HVY06_RS19630	COG0530	calcium, potassium:sodium antiporter activity
HVY06_RS19640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVY06_RS19645	COG3117	lipopolysaccharide transmembrane transporter activity
HVY06_RS19650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVY06_RS19655	COG1137	ATPase activity
HVY06_RS19665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY06_RS19680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY06_RS19690	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVY06_RS19695	COG2198	Histidine kinase
HVY06_RS19695	COG5002	protein histidine kinase activity
HVY06_RS19695	COG0784	Response regulator, receiver
HVY06_RS19700	COG1242	4 iron, 4 sulfur cluster binding
HVY06_RS19705	COG0069	glutamate synthase activity
HVY06_RS19705	COG0070	glutamate synthase
HVY06_RS19705	COG0067	glutamate synthase
HVY06_RS19710	COG0493	'glutamate synthase
HVY06_RS19715	COG3539	Fimbrial protein
HVY06_RS19730	COG3121	Chaperone
HVY06_RS19735	COG3539	Fimbrial protein
HVY06_RS19750	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY06_RS19755	COG0402	S-adenosylhomocysteine deaminase activity
HVY06_RS19760	COG2731	YhcH YjgK YiaL family protein
HVY06_RS19780	COG2186	Transcriptional regulator
HVY06_RS19785	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY06_RS19790	COG2969	positive regulation of protein catabolic process
HVY06_RS19795	COG0625	glutathione transferase activity
HVY06_RS19800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HVY06_RS19810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY06_RS19815	COG3105	Protein conserved in bacteria
HVY06_RS19820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY06_RS19825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY06_RS19845	COG2732	(Barnase) inhibitor
HVY06_RS19865	COG0583	DNA-binding transcription factor activity
HVY06_RS19870	COG0312	modulator of DNA gyrase
HVY06_RS19875	COG3164	Protein of unknown function
HVY06_RS19880	COG1530	ribonuclease E activity
HVY06_RS19890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVY06_RS19895	COG1792	Involved in formation and maintenance of cell shape
HVY06_RS19900	COG1077	Cell shape determining protein MreB Mrl
HVY06_RS19910	COG2199	diguanylate cyclase activity
HVY06_RS19910	COG2200	EAL domain
HVY06_RS19915	COG0604	alcohol dehydrogenase
HVY06_RS19930	COG0511	ligase activity, forming carbon-carbon bonds
HVY06_RS19935	COG0439	Biotin carboxylase
HVY06_RS19940	COG3924	membrane
HVY06_RS19945	COG4145	pantothenate transmembrane transporter activity
HVY06_RS19975	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVY06_RS19985	COG1309	transcriptional regulator
HVY06_RS19990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY06_RS19995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY06_RS20005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY06_RS20010	COG4597	amino acid ABC transporter
HVY06_RS20015	COG0765	amino acid transport
HVY06_RS20020	COG1126	abc transporter atp-binding protein
HVY06_RS20055	COG3290	protein histidine kinase activity
HVY06_RS20060	COG4565	transcriptional regulatory protein
HVY06_RS20065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY06_RS20070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY06_RS20070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY06_RS20075	COG3647	Membrane
HVY06_RS20080	COG2211	Major facilitator Superfamily
HVY06_RS20085	COG1486	melibiose metabolic process
HVY06_RS20090	COG2169	Transcriptional regulator
HVY06_RS20095	COG1982	Orn Lys Arg decarboxylase major
HVY06_RS20100	COG2207	Transcriptional regulator
HVY06_RS20105	COG0531	amino acid
HVY06_RS20115	COG0745	RESPONSE REGULATOR receiver
HVY06_RS20145	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVY06_RS20150	COG2824	Alkylphosphonate utilization operon protein PhnA
HVY06_RS20155	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVY06_RS20160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HVY06_RS20165	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVY06_RS20170	COG3639	organic phosphonate transmembrane transporter activity
HVY06_RS20175	COG2188	Transcriptional regulator
HVY06_RS20180	COG3624	Phosphonate C-P lyase system protein PhnG
HVY06_RS20185	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVY06_RS20190	COG3626	phosphonate metabolism
HVY06_RS20195	COG3627	carbon phosphorus lyase activity
HVY06_RS20200	COG4107	phosphonate C-P lyase system protein PhnK
HVY06_RS20205	COG4778	phosphonate C-P lyase system protein PhnL
HVY06_RS20210	COG3454	Phosphonate metabolism
HVY06_RS20215	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HVY06_RS20220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVY06_RS20245	COG1129	ABC transporter
HVY06_RS20250	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS20275	COG0745	RESPONSE REGULATOR receiver
HVY06_RS20285	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY06_RS20290	COG1301	dicarboxylic acid transport
HVY06_RS20295	COG4235	cytochrome complex assembly
HVY06_RS20300	COG3088	subunit of a heme lyase
HVY06_RS20305	COG1138	Cytochrome C-type biogenesis protein
HVY06_RS20310	COG3301	Polysulphide reductase, NrfD
HVY06_RS20315	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS20320	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVY06_RS20335	COG3162	membrane
HVY06_RS20355	COG1346	cytolysis
HVY06_RS20360	COG1380	Effector of murein hydrolase LrgA
HVY06_RS20365	COG0583	DNA-binding transcription factor activity
HVY06_RS20370	COG1943	Transposase
HVY06_RS20375	COG0025	NhaP-type Na H and K H
HVY06_RS20380	COG2252	PERMEase
HVY06_RS20385	COG0789	Transcriptional regulator
HVY06_RS20395	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY06_RS20410	COG0629	single-stranded DNA binding
HVY06_RS20415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVY06_RS20420	COG2315	Protein conserved in bacteria
HVY06_RS20425	COG3700	Belongs to the class B bacterial acid phosphatase family
HVY06_RS20430	COG1448	Aminotransferase
HVY06_RS20435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY06_RS20440	COG0305	Participates in initiation and elongation during chromosome replication
HVY06_RS20455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY06_RS20465	COG0735	belongs to the Fur family
HVY06_RS20470	COG3237	CsbD-like
HVY06_RS20475	COG0534	Mate efflux family protein
HVY06_RS20485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVY06_RS20520	COG2182	Extracellular solute-binding protein
HVY06_RS20530	COG3833	ABC-type maltose transport systems, permease component
HVY06_RS20535	COG0477	Major facilitator Superfamily
HVY06_RS20535	COG2814	Major facilitator Superfamily
HVY06_RS20540	COG3223	Belongs to the PsiE family
HVY06_RS20545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY06_RS20570	COG0527	aspartate kinase activity
HVY06_RS20575	COG3541	Predicted nucleotidyltransferase
HVY06_RS20585	COG4650	regulator
HVY06_RS20595	COG1187	pseudouridine synthase activity
HVY06_RS20610	COG3657	addiction module killer protein
HVY06_RS20615	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY06_RS20640	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HVY06_RS20650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY06_RS20680	COG0151	Belongs to the GarS family
HVY06_RS20685	COG2204	response regulator
HVY06_RS20745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY06_RS20750	COG2104	thiamine diphosphate biosynthetic process
HVY06_RS20765	COG1278	Cold shock
HVY06_RS20775	COG0085	RNA polymerase activity
HVY06_RS20780	COG0222	ribosome binding
HVY06_RS20785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HVY06_RS20800	COG0250	Participates in transcription elongation, termination and antitermination
HVY06_RS20810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HVY06_RS20845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVY06_RS20905	COG0583	DNA-binding transcription factor activity
HVY06_RS20920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVY06_RS20940	COG2207	Transcriptional regulator
HVY06_RS20945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY06_RS20950	COG0371	Dehydrogenase
HVY06_RS20970	COG0527	aspartate kinase activity
HVY06_RS20970	COG0460	homoserine dehydrogenase
HVY06_RS20975	COG0626	cystathionine gamma-synthase activity
HVY06_RS20985	COG2211	Major facilitator Superfamily
HVY06_RS20995	COG0254	rRNA binding
HVY06_RS21000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVY06_RS21005	COG1609	Transcriptional regulator
HVY06_RS21010	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY06_RS21020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HVY06_RS21025	COG1575	Belongs to the MenA family. Type 1 subfamily
HVY06_RS21035	COG3074	FtsZ-dependent cytokinesis
HVY06_RS21040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVY06_RS21050	COG1494	fructose-1,6-bisphosphatase
HVY06_RS21060	COG3152	Membrane
HVY06_RS21075	COG0471	metal ion transport
HVY06_RS21115	COG3678	ATP-independent chaperone mediated protein folding
HVY06_RS21120	COG0745	RESPONSE REGULATOR receiver
HVY06_RS21125	COG2205	protein histidine kinase activity
HVY06_RS21130	COG2258	MOSC domain
HVY06_RS21135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY06_RS21180	COG1454	alcohol dehydrogenase
HVY06_RS21195	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY06_RS21230	COG0437	4 iron, 4 sulfur cluster binding
HVY06_RS21235	COG2864	formate dehydrogenase
HVY06_RS21245	COG0456	acetyltransferase
HVY06_RS21250	COG1490	D-aminoacyl-tRNA deacylase activity
HVY06_RS21260	COG1011	Hydrolase
HVY06_RS21270	COG0477	Major facilitator Superfamily
HVY06_RS21280	COG1063	alcohol dehydrogenase
HVY06_RS21285	COG3684	Belongs to the aldolase LacD family
HVY06_RS21290	COG2084	Dehydrogenase
HVY06_RS21295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS21300	COG1349	DNA-binding transcription factor activity
HVY06_RS21305	COG2271	Major facilitator Superfamily
HVY06_RS21310	COG1082	Xylose isomerase domain protein TIM barrel
HVY06_RS21315	COG2188	Transcriptional regulator
HVY06_RS21330	COG3852	Histidine kinase
HVY06_RS21345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY06_RS21370	COG0204	Acyl-transferase
HVY06_RS21385	COG3084	Protein conserved in bacteria
HVY06_RS21390	COG0746	molybdenum cofactor guanylyltransferase activity
HVY06_RS21395	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVY06_RS21435	COG1739	Uncharacterized protein family UPF0029
HVY06_RS21460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY06_RS21475	COG0805	protein transport
HVY06_RS21495	COG3165	ubiquinone biosynthetic process from chorismate
HVY06_RS21515	COG0412	Dienelactone hydrolase
HVY06_RS21520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HVY06_RS21525	COG0583	DNA-binding transcription factor activity
HVY06_RS21530	COG0697	spore germination
HVY06_RS21535	COG0561	phosphatase activity
HVY06_RS21540	COG2267	carboxylic ester hydrolase activity
HVY06_RS21545	COG1280	lysine exporter protein (LysE YggA)
HVY06_RS21550	COG1280	lysine exporter protein (LysE YggA)
HVY06_RS21560	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVY06_RS21570	COG2962	Rard protein
HVY06_RS21575	COG0598	Magnesium transport protein CorA
HVY06_RS21585	COG1011	Hydrolase
HVY06_RS21605	COG5567	small periplasmic lipoprotein
HVY06_RS21630	COG2959	enzyme of heme biosynthesis
HVY06_RS21635	COG3071	HemY protein
HVY06_RS21680	COG2244	polysaccharide biosynthetic process
HVY06_RS21685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY06_RS21690	COG0456	acetyltransferase
HVY06_RS21695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY06_RS21700	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY06_RS21705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVY06_RS21710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVY06_RS21720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVY06_RS21725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVY06_RS21735	COG3118	belongs to the thioredoxin family
HVY06_RS21770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY06_RS21785	COG3978	acetolactate synthase activity
HVY06_RS21805	COG3085	chromosome segregation
HVY06_RS21845	COG2186	Transcriptional regulator
HVY06_RS21850	COG0477	Major facilitator Superfamily
HVY06_RS21855	COG1609	Transcriptional regulator
HVY06_RS21860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY06_RS21870	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY06_RS21880	COG1869	D-ribose catabolic process
HVY06_RS21905	COG1522	sequence-specific DNA binding
HVY06_RS21910	COG0716	FMN binding
HVY06_RS21925	COG3312	ion transport
HVY06_RS21950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HVY06_RS21955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HVY06_RS21965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HVY06_RS21990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY06_RS21995	COG0573	inorganic phosphate transmembrane transporter activity
HVY06_RS22000	COG0581	inorganic phosphate transmembrane transporter activity
HVY06_RS22010	COG0704	Plays a role in the regulation of phosphate uptake
HVY06_RS22015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY06_RS22020	COG2252	PERMEase
HVY06_RS22025	COG0431	NADPH-dependent FMN reductase
HVY06_RS22030	COG2091	lysine biosynthetic process via aminoadipic acid
HVY06_RS22065	COG0230	Belongs to the bacterial ribosomal protein bL34 family