locus-tag	class	description
HVY72_RS00025	COG0561	phosphatase activity
HVY72_RS00040	COG0823	Involved in the tonB-independent uptake of proteins
HVY72_RS00045	COG5645	(Lipo)protein
HVY72_RS00065	COG2207	Transcriptional regulator
HVY72_RS00070	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY72_RS00075	COG3119	arylsulfatase activity
HVY72_RS00080	COG2149	membrane
HVY72_RS00090	COG0641	radical SAM
HVY72_RS00100	COG2610	gluconate transmembrane transporter activity
HVY72_RS00105	COG0583	DNA-binding transcription factor activity
HVY72_RS00115	COG2814	Major facilitator Superfamily
HVY72_RS00135	COG0028	Belongs to the TPP enzyme family
HVY72_RS00140	COG0440	acetolactate synthase activity
HVY72_RS00145	COG1349	DNA-binding transcription factor activity
HVY72_RS00155	COG0738	Major facilitator superfamily
HVY72_RS00165	COG2197	response regulator
HVY72_RS00205	COG2723	6-phospho-beta-galactosidase activity
HVY72_RS00230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS00230	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS00235	COG3715	PTS system
HVY72_RS00240	COG3716	PTS system mannose fructose sorbose family IID component
HVY72_RS00255	COG1464	Belongs to the NlpA lipoprotein family
HVY72_RS00260	COG0697	spore germination
HVY72_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS00280	COG0604	alcohol dehydrogenase
HVY72_RS00285	COG0583	DNA-binding transcription factor activity
HVY72_RS00305	COG2771	luxR family
HVY72_RS00350	COG2211	Major facilitator Superfamily
HVY72_RS00355	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY72_RS00360	COG3711	transcriptional antiterminator
HVY72_RS00365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS00365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS00365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS00370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS00375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS00375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS00385	COG0191	fructose-bisphosphate aldolase activity
HVY72_RS00395	COG2982	Protein involved in outer membrane biogenesis
HVY72_RS00400	COG2233	PERMEase
HVY72_RS00405	COG0786	glutamate:sodium symporter activity
HVY72_RS00410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVY72_RS00415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY72_RS00420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY72_RS00440	COG2860	membrane
HVY72_RS00445	COG1561	YicC-like family, N-terminal region
HVY72_RS00470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVY72_RS00485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HVY72_RS00500	COG1519	Transferase
HVY72_RS00505	COG0438	transferase activity, transferring glycosyl groups
HVY72_RS00510	COG0515	serine threonine protein kinase
HVY72_RS00515	COG1442	glycosyl transferase family 8
HVY72_RS00520	COG1442	glycosyl transferase family 8
HVY72_RS00525	COG1442	glycosyl transferase family 8
HVY72_RS00530	COG0859	PFAM glycosyl transferase family 9
HVY72_RS00535	COG1215	transferase activity, transferring glycosyl groups
HVY72_RS00540	COG3307	-O-antigen
HVY72_RS00550	COG0859	PFAM glycosyl transferase family 9
HVY72_RS00560	COG0156	8-amino-7-oxononanoate synthase activity
HVY72_RS00570	COG1216	Glycosyl transferase, family 2
HVY72_RS00575	COG2861	carbohydrate metabolic process
HVY72_RS00580	COG4942	peptidase
HVY72_RS00590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY72_RS00595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY72_RS00610	COG1045	serine acetyltransferase
HVY72_RS00615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVY72_RS00620	COG1304	FMN binding
HVY72_RS00625	COG2186	Transcriptional regulator
HVY72_RS00645	COG3722	fumarate hydratase activity
HVY72_RS00655	COG2213	PTS system mannitol-specific
HVY72_RS00655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS00665	COG1566	PFAM secretion protein HlyD family protein
HVY72_RS00670	COG0625	glutathione transferase activity
HVY72_RS00680	COG3276	selenocysteine insertion sequence binding
HVY72_RS00685	COG1454	alcohol dehydrogenase
HVY72_RS00690	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS00700	COG1566	PFAM secretion protein HlyD family protein
HVY72_RS00705	COG0583	DNA-binding transcription factor activity
HVY72_RS00710	COG3713	MltA-interacting MipA family protein
HVY72_RS00720	COG2211	Major facilitator Superfamily
HVY72_RS00725	COG4977	sequence-specific DNA binding
HVY72_RS00725	COG1917	Cupin 2, conserved barrel domain protein
HVY72_RS00730	COG0235	Class ii aldolase
HVY72_RS00735	COG3623	hexulose-6-phosphate isomerase
HVY72_RS00740	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVY72_RS00745	COG1070	Carbohydrate kinase
HVY72_RS00750	COG2271	Major facilitator Superfamily
HVY72_RS00760	COG2731	YhcH YjgK YiaL family protein
HVY72_RS00770	COG1414	Transcriptional regulator
HVY72_RS00775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY72_RS00780	COG3977	Valine--pyruvate aminotransferase
HVY72_RS00785	COG0366	Alpha amylase catalytic
HVY72_RS00790	COG2992	FlgJ-related protein
HVY72_RS00795	COG2207	Transcriptional regulator
HVY72_RS00795	COG1609	Transcriptional regulator
HVY72_RS00805	COG1070	Carbohydrate kinase
HVY72_RS00810	COG4682	membrane
HVY72_RS00815	COG3274	enterobacterial common antigen metabolic process
HVY72_RS00840	COG1278	Cold shock
HVY72_RS00845	COG2944	sequence-specific DNA binding
HVY72_RS00860	COG2814	Major facilitator Superfamily
HVY72_RS00865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS00875	COG1609	Transcriptional regulator
HVY72_RS00880	COG2885	chlorophyll binding
HVY72_RS00885	COG0243	molybdopterin cofactor binding
HVY72_RS00890	COG0456	acetyltransferase
HVY72_RS00895	COG2818	Glycosylase
HVY72_RS00900	COG5571	outer membrane autotransporter
HVY72_RS00905	COG2223	nitrite transmembrane transporter activity
HVY72_RS00925	COG0747	negative chemotaxis
HVY72_RS00930	COG0601	transmembrane transport
HVY72_RS00935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY72_RS00940	COG0444	Belongs to the ABC transporter superfamily
HVY72_RS00945	COG4608	Belongs to the ABC transporter superfamily
HVY72_RS00950	COG2204	response regulator
HVY72_RS00955	COG0814	amino acid
HVY72_RS00960	COG0626	cystathionine gamma-synthase activity
HVY72_RS00970	COG2200	EAL domain
HVY72_RS00970	COG2199	diguanylate cyclase activity
HVY72_RS00985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS00990	COG2200	EAL domain
HVY72_RS00995	COG2982	Protein involved in outer membrane biogenesis
HVY72_RS01000	COG0477	Major facilitator Superfamily
HVY72_RS01005	COG1295	ribonuclease BN
HVY72_RS01010	COG0583	DNA-binding transcription factor activity
HVY72_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS01020	COG2197	response regulator
HVY72_RS01030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY72_RS01045	COG1858	cytochrome C peroxidase
HVY72_RS01050	COG2188	Transcriptional regulator
HVY72_RS01055	COG2222	sugar isomerase
HVY72_RS01060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY72_RS01075	COG0583	DNA-binding transcription factor activity
HVY72_RS01080	COG4948	Mandelate Racemase Muconate Lactonizing
HVY72_RS01085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY72_RS01090	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVY72_RS01095	COG0339	signal peptide processing
HVY72_RS01110	COG1959	2 iron, 2 sulfur cluster binding
HVY72_RS01120	COG0589	response to stress
HVY72_RS01130	COG0306	phosphate transporter
HVY72_RS01135	COG2081	HI0933 family
HVY72_RS01140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS01145	COG1129	ABC transporter
HVY72_RS01145	COG0842	Transport permease protein
HVY72_RS01150	COG0842	Transport permease protein
HVY72_RS01165	COG3479	Phenolic acid decarboxylase
HVY72_RS01170	COG2091	lysine biosynthetic process via aminoadipic acid
HVY72_RS01175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY72_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS01190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY72_RS01215	COG1216	Glycosyl transferase, family 2
HVY72_RS01235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVY72_RS01265	COG0628	permease
HVY72_RS01270	COG0477	Major facilitator Superfamily
HVY72_RS01280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVY72_RS01295	COG3714	YhhN family
HVY72_RS01305	COG3776	membrane
HVY72_RS01310	COG0742	ribosomal rna small subunit methyltransferase
HVY72_RS01315	COG0552	protein localization to endoplasmic reticulum
HVY72_RS01320	COG2884	Cell division ATP-binding protein ftsE
HVY72_RS01325	COG2177	Part of the ABC transporter FtsEX involved in
HVY72_RS01345	COG0683	leucine binding
HVY72_RS01355	COG4177	L-phenylalanine transmembrane transporter activity
HVY72_RS01360	COG0411	ABC transporter
HVY72_RS01365	COG0410	ABC transporter
HVY72_RS01395	COG0584	glycerophosphoryl diester phosphodiesterase
HVY72_RS01405	COG0405	Gamma-glutamyltransferase
HVY72_RS01415	COG1247	-acetyltransferase
HVY72_RS01420	COG0673	inositol 2-dehydrogenase activity
HVY72_RS01425	COG1741	Belongs to the pirin family
HVY72_RS01430	COG1609	Transcriptional regulator
HVY72_RS01435	COG3265	gluconokinase activity
HVY72_RS01440	COG2610	gluconate transmembrane transporter activity
HVY72_RS01460	COG2095	MarC family integral membrane protein
HVY72_RS01465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY72_RS01490	COG0058	SHG alpha-glucan phosphorylase activity
HVY72_RS01495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY72_RS01510	COG1349	DNA-binding transcription factor activity
HVY72_RS01520	COG0058	SHG alpha-glucan phosphorylase activity
HVY72_RS01525	COG1640	4-alpha-glucanotransferase
HVY72_RS01530	COG2610	gluconate transmembrane transporter activity
HVY72_RS01540	COG1040	competence protein
HVY72_RS01565	COG1918	ferrous iron import across plasma membrane
HVY72_RS01570	COG2183	response to ionizing radiation
HVY72_RS01575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY72_RS01595	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY72_RS01605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVY72_RS01610	COG1011	Hydrolase
HVY72_RS01620	COG0494	nUDIX hydrolase
HVY72_RS01625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVY72_RS01630	COG4972	Pilus assembly protein
HVY72_RS01635	COG3166	PFAM Fimbrial assembly family protein
HVY72_RS01650	COG4796	Type ii and iii secretion system protein
HVY72_RS01665	COG3266	domain, Protein
HVY72_RS01670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY72_RS01675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY72_RS01685	COG0180	Tryptophanyl-tRNA synthetase
HVY72_RS01690	COG2188	Transcriptional regulator
HVY72_RS01700	COG3457	Alanine racemase
HVY72_RS01705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVY72_RS01710	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVY72_RS01725	COG0626	cystathionine gamma-synthase activity
HVY72_RS01750	COG2146	nitrite reductase [NAD(P)H] activity
HVY72_RS01755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY72_RS01780	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY72_RS01785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY72_RS01790	COG1289	transmembrane transporter activity
HVY72_RS01800	COG1765	OsmC-like protein
HVY72_RS01805	COG3954	Phosphoribulokinase
HVY72_RS01815	COG0429	hydrolase of the alpha beta-hydrolase fold
HVY72_RS01825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVY72_RS01835	COG0488	(ABC) transporter
HVY72_RS01850	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVY72_RS01855	COG1047	Peptidyl-prolyl cis-trans
HVY72_RS01865	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY72_RS01870	COG2964	Protein conserved in bacteria
HVY72_RS01895	COG0049	tRNA binding
HVY72_RS01925	COG0051	transcription antitermination factor activity, RNA binding
HVY72_RS01935	COG0088	Forms part of the polypeptide exit tunnel
HVY72_RS01950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HVY72_RS02025	COG0200	Binds to the 23S rRNA
HVY72_RS02030	COG0201	protein transport
HVY72_RS02045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HVY72_RS02070	COG0789	Transcriptional regulator
HVY72_RS02075	COG3036	rescue of stalled ribosome
HVY72_RS02085	COG0569	domain protein
HVY72_RS02105	COG0758	DNA mediated transformation
HVY72_RS02115	COG0551	DNA topoisomerase type I activity
HVY72_RS02135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY72_RS02175	COG1126	abc transporter atp-binding protein
HVY72_RS02180	COG0765	amino acid transport
HVY72_RS02185	COG4597	amino acid ABC transporter
HVY72_RS02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS02200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY72_RS02205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS02210	COG1309	transcriptional regulator
HVY72_RS02220	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVY72_RS02245	COG4145	pantothenate transmembrane transporter activity
HVY72_RS02250	COG3924	membrane
HVY72_RS02255	COG0439	Biotin carboxylase
HVY72_RS02260	COG0511	ligase activity, forming carbon-carbon bonds
HVY72_RS02275	COG0604	alcohol dehydrogenase
HVY72_RS02280	COG2200	EAL domain
HVY72_RS02280	COG2199	diguanylate cyclase activity
HVY72_RS02285	COG1077	Cell shape determining protein MreB Mrl
HVY72_RS02290	COG1792	Involved in formation and maintenance of cell shape
HVY72_RS02295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVY72_RS02310	COG3164	Protein of unknown function
HVY72_RS02315	COG0312	modulator of DNA gyrase
HVY72_RS02320	COG0583	DNA-binding transcription factor activity
HVY72_RS02340	COG2732	(Barnase) inhibitor
HVY72_RS02360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY72_RS02365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY72_RS02370	COG3105	Protein conserved in bacteria
HVY72_RS02375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY72_RS02390	COG0625	glutathione transferase activity
HVY72_RS02395	COG2969	positive regulation of protein catabolic process
HVY72_RS02400	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY72_RS02425	COG2731	YhcH YjgK YiaL family protein
HVY72_RS02430	COG0402	S-adenosylhomocysteine deaminase activity
HVY72_RS02435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY72_RS02440	COG0493	'glutamate synthase
HVY72_RS02445	COG0067	glutamate synthase
HVY72_RS02445	COG0069	glutamate synthase activity
HVY72_RS02445	COG0070	glutamate synthase
HVY72_RS02450	COG1242	4 iron, 4 sulfur cluster binding
HVY72_RS02455	COG2198	Histidine kinase
HVY72_RS02455	COG5002	protein histidine kinase activity
HVY72_RS02455	COG0784	Response regulator, receiver
HVY72_RS02460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVY72_RS02470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS02485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY72_RS02495	COG1137	ATPase activity
HVY72_RS02500	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVY72_RS02505	COG3117	lipopolysaccharide transmembrane transporter activity
HVY72_RS02510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVY72_RS02520	COG0530	calcium, potassium:sodium antiporter activity
HVY72_RS02525	COG1127	ABC transporter
HVY72_RS02530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVY72_RS02535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY72_RS02540	COG2854	intermembrane phospholipid transfer
HVY72_RS02545	COG3113	response to antibiotic
HVY72_RS02550	COG5007	Belongs to the BolA IbaG family
HVY72_RS02560	COG3423	Transcriptional regulator
HVY72_RS02565	COG0142	geranyltranstransferase activity
HVY72_RS02570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HVY72_RS02575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HVY72_RS02580	COG0697	spore germination
HVY72_RS02590	COG2027	D-alanyl-D-alanine carboxypeptidase
HVY72_RS02600	COG1534	Rna-binding protein
HVY72_RS02610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVY72_RS02615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVY72_RS02625	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY72_RS02630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY72_RS02635	COG0583	DNA-binding transcription factor activity
HVY72_RS02640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY72_RS02665	COG0195	Participates in both transcription termination and antitermination
HVY72_RS02675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HVY72_RS02705	COG0513	Belongs to the DEAD box helicase family
HVY72_RS02710	COG0814	amino acid
HVY72_RS02715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY72_RS02720	COG0826	peptidase U32
HVY72_RS02725	COG0826	peptidase U32
HVY72_RS02730	COG3154	lipid carrier protein
HVY72_RS02735	COG3153	acetyltransferase
HVY72_RS02750	COG0702	epimerase
HVY72_RS02755	COG2823	Periplasmic or secreted lipoprotein
HVY72_RS02775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVY72_RS02780	COG0363	glucosamine-6-phosphate deaminase activity
HVY72_RS02785	COG3716	PTS system mannose fructose sorbose family IID component
HVY72_RS02790	COG3715	PTS system
HVY72_RS02795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS02805	COG2222	sugar isomerase
HVY72_RS02810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY72_RS02815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS02820	COG3716	PTS system mannose fructose sorbose family IID component
HVY72_RS02830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS02840	COG1349	DNA-binding transcription factor activity
HVY72_RS02845	COG1349	DNA-binding transcription factor activity
HVY72_RS02850	COG1940	carbohydrate kinase activity
HVY72_RS02855	COG0673	inositol 2-dehydrogenase activity
HVY72_RS02860	COG3842	ATPase activity
HVY72_RS02865	COG0395	ABC-type sugar transport system, permease component
HVY72_RS02870	COG1175	transmembrane transport
HVY72_RS02880	COG2721	sulfolactate sulfo-lyase activity
HVY72_RS02885	COG2271	Major facilitator Superfamily
HVY72_RS02895	COG2084	Dehydrogenase
HVY72_RS02900	COG1929	Belongs to the glycerate kinase type-1 family
HVY72_RS02910	COG0583	DNA-binding transcription factor activity
HVY72_RS02930	COG1882	Formate acetyltransferase
HVY72_RS02935	COG0251	oxidation-reduction process
HVY72_RS02940	COG1760	l-serine dehydratase
HVY72_RS02945	COG0814	amino acid
HVY72_RS02960	COG1741	Belongs to the pirin family
HVY72_RS02965	COG0583	DNA-binding transcription factor activity
HVY72_RS02970	COG3152	Membrane
HVY72_RS02975	COG0435	Glutathione S-transferase
HVY72_RS02980	COG2259	Doxx family
HVY72_RS02990	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVY72_RS02995	COG4575	ribosome binding
HVY72_RS03000	COG1422	Protein of unknown function (DUF1090)
HVY72_RS03010	COG0586	Pfam SNARE associated Golgi protein
HVY72_RS03015	COG2186	Transcriptional regulator
HVY72_RS03020	COG2271	Major facilitator Superfamily
HVY72_RS03030	COG2721	sulfolactate sulfo-lyase activity
HVY72_RS03050	COG0673	inositol 2-dehydrogenase activity
HVY72_RS03055	COG1451	nucleotide metabolic process
HVY72_RS03065	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVY72_RS03065	COG1902	pentaerythritol trinitrate reductase activity
HVY72_RS03070	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVY72_RS03070	COG3408	Glycogen debranching enzyme
HVY72_RS03080	COG0531	amino acid
HVY72_RS03085	COG2731	YhcH YjgK YiaL family protein
HVY72_RS03090	COG3250	beta-galactosidase activity
HVY72_RS03095	COG1609	Transcriptional regulator
HVY72_RS03100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVY72_RS03110	COG0840	transmembrane signaling receptor activity
HVY72_RS03115	COG1695	Transcriptional regulator
HVY72_RS03120	COG2375	cellular response to nickel ion
HVY72_RS03130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY72_RS03280	COG4626	Terminase
HVY72_RS03280	COG1802	Transcriptional regulator
HVY72_RS03310	COG0358	DNA primase activity
HVY72_RS03315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVY72_RS03320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HVY72_RS03325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY72_RS03335	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HVY72_RS03365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS03370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS03385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY72_RS03400	COG4991	sh3 domain protein
HVY72_RS03405	COG3025	triphosphatase activity
HVY72_RS03460	COG3384	dioxygenase
HVY72_RS03465	COG0754	glutathionylspermidine amidase activity
HVY72_RS03480	COG0494	nUDIX hydrolase
HVY72_RS03485	COG3151	Protein conserved in bacteria
HVY72_RS03490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY72_RS03495	COG3150	esterase
HVY72_RS03500	COG0187	DNA topoisomerase II activity
HVY72_RS03505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVY72_RS03510	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY72_RS03525	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY72_RS03545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY72_RS03560	COG0471	metal ion transport
HVY72_RS03565	COG0656	L-ascorbic acid biosynthetic process
HVY72_RS03570	COG1979	alcohol dehydrogenase
HVY72_RS03575	COG2207	Transcriptional regulator
HVY72_RS03580	COG0586	Pfam SNARE associated Golgi protein
HVY72_RS03585	COG0626	cystathionine gamma-synthase activity
HVY72_RS03595	COG0848	biopolymer transport protein
HVY72_RS03615	COG0667	Aldo Keto reductase
HVY72_RS03625	COG0840	transmembrane signaling receptor activity
HVY72_RS03635	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY72_RS03640	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS03645	COG5557	Pfam Polysulphide reductase, NrfD
HVY72_RS03650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY72_RS03655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY72_RS03660	COG1773	rubredoxin
HVY72_RS03670	COG0298	carbon dioxide binding
HVY72_RS03675	COG0625	glutathione transferase activity
HVY72_RS03680	COG0243	molybdopterin cofactor binding
HVY72_RS03685	COG0754	glutathionylspermidine amidase activity
HVY72_RS03710	COG2885	chlorophyll binding
HVY72_RS03770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HVY72_RS03775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HVY72_RS03780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HVY72_RS03860	COG2003	Belongs to the UPF0758 family
HVY72_RS03890	COG3596	GTP binding
HVY72_RS03905	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY72_RS03905	COG1674	ftsk spoiiie
HVY72_RS03945	COG0464	growth
HVY72_RS04070	COG0582	viral genome integration into host DNA
HVY72_RS04080	COG1811	Na channel or pump
HVY72_RS04085	COG1982	Orn Lys Arg decarboxylase major
HVY72_RS04090	COG2211	Major facilitator Superfamily
HVY72_RS04105	COG1194	a g-specific adenine glycosylase
HVY72_RS04115	COG3171	Protein conserved in bacteria
HVY72_RS04125	COG0252	asparaginase activity
HVY72_RS04130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY72_RS04145	COG0762	integral membrane protein
HVY72_RS04150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVY72_RS04170	COG2805	Type II/IV secretion system protein
HVY72_RS04185	COG0189	ligase activity
HVY72_RS04190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVY72_RS04195	COG2356	endonuclease I
HVY72_RS04205	COG2814	Major facilitator Superfamily
HVY72_RS04225	COG1166	arginine decarboxylase activity
HVY72_RS04240	COG0501	Belongs to the peptidase M48B family
HVY72_RS04245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY72_RS04260	COG0191	fructose-bisphosphate aldolase activity
HVY72_RS04265	COG0668	transmembrane transport
HVY72_RS04270	COG1279	arginine transmembrane transporter activity
HVY72_RS04275	COG2968	Membrane
HVY72_RS04280	COG0583	DNA-binding transcription factor activity
HVY72_RS04285	COG0427	acetyl-CoA hydrolase
HVY72_RS04290	COG1024	Enoyl-CoA hydratase
HVY72_RS04295	COG1703	isobutyryl-CoA mutase activity
HVY72_RS04300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY72_RS04300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY72_RS04315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY72_RS04320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVY72_RS04340	COG0006	proline dipeptidase activity
HVY72_RS04345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY72_RS04350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY72_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS04375	COG2723	6-phospho-beta-galactosidase activity
HVY72_RS04380	COG1737	Transcriptional regulator
HVY72_RS04390	COG1272	protein, Hemolysin III
HVY72_RS04400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVY72_RS04425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVY72_RS04445	COG4942	peptidase
HVY72_RS04455	COG4974	Belongs to the 'phage' integrase family
HVY72_RS04485	COG0457	Tetratricopeptide repeat
HVY72_RS04490	COG1649	PFAM Uncharacterised BCR, COG1649
HVY72_RS04490	COG0726	polysaccharide deacetylase
HVY72_RS04495	COG1215	transferase activity, transferring glycosyl groups
HVY72_RS04505	COG3592	Divergent 4Fe-4S mono-cluster
HVY72_RS04510	COG2388	GCN5-related N-acetyl-transferase
HVY72_RS04515	COG0583	DNA-binding transcription factor activity
HVY72_RS04520	COG0666	response to abiotic stimulus
HVY72_RS04530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY72_RS04535	COG1304	FMN binding
HVY72_RS04545	COG0549	Belongs to the carbamate kinase family
HVY72_RS04550	COG0402	S-adenosylhomocysteine deaminase activity
HVY72_RS04565	COG0814	amino acid
HVY72_RS04580	COG0183	Belongs to the thiolase family
HVY72_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS04595	COG2814	Major facilitator Superfamily
HVY72_RS04605	COG1794	racemase activity, acting on amino acids and derivatives
HVY72_RS04610	COG0583	DNA-binding transcription factor activity
HVY72_RS04620	COG1609	Transcriptional regulator
HVY72_RS04640	COG0667	Aldo Keto reductase
HVY72_RS04650	COG0861	Integral membrane protein TerC family
HVY72_RS04680	COG2165	general secretion pathway protein
HVY72_RS04685	COG4795	General secretion pathway protein
HVY72_RS04695	COG4967	type IV pilus modification protein PilV
HVY72_RS04700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVY72_RS04710	COG1074	ATP-dependent DNA helicase activity
HVY72_RS04715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY72_RS04720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVY72_RS04720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVY72_RS04725	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY72_RS04745	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVY72_RS04750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVY72_RS04755	COG2166	iron-sulfur cluster assembly
HVY72_RS04760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVY72_RS04770	COG0583	DNA-binding transcription factor activity
HVY72_RS04775	COG2363	Small membrane protein
HVY72_RS04785	COG1349	DNA-binding transcription factor activity
HVY72_RS04795	COG1070	Carbohydrate kinase
HVY72_RS04805	COG0738	Major facilitator superfamily
HVY72_RS04810	COG0235	Class ii aldolase
HVY72_RS04815	COG1454	alcohol dehydrogenase
HVY72_RS04825	COG1760	l-serine dehydratase
HVY72_RS04830	COG0814	amino acid
HVY72_RS04835	COG1611	Belongs to the LOG family
HVY72_RS04850	COG3098	single-species biofilm formation
HVY72_RS04855	COG0564	pseudouridine synthase activity
HVY72_RS04860	COG0716	FMN binding
HVY72_RS04865	COG2271	Major facilitator Superfamily
HVY72_RS04870	COG4948	Mandelate Racemase Muconate Lactonizing
HVY72_RS04875	COG4948	Mandelate Racemase Muconate Lactonizing
HVY72_RS04880	COG1929	Belongs to the glycerate kinase type-1 family
HVY72_RS04885	COG4999	Histidine kinase
HVY72_RS04885	COG2205	protein histidine kinase activity
HVY72_RS04885	COG3437	response regulator, receiver
HVY72_RS04885	COG3850	Histidine kinase
HVY72_RS04895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY72_RS04900	COG3956	TIGRFAM MazG family protein
HVY72_RS04920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS04920	COG2190	(PTS) system
HVY72_RS04920	COG1263	PTS System
HVY72_RS04925	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HVY72_RS04930	COG0602	queuosine metabolic process
HVY72_RS04935	COG0720	synthase
HVY72_RS04955	COG2234	aminopeptidase activity
HVY72_RS05010	COG4942	peptidase
HVY72_RS05010	COG1388	LysM domain
HVY72_RS05025	COG0163	prenyltransferase activity
HVY72_RS05030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY72_RS05070	COG1538	Outer membrane efflux protein
HVY72_RS05085	COG2199	diguanylate cyclase activity
HVY72_RS05085	COG2200	EAL domain
HVY72_RS05085	COG3287	FIST C domain
HVY72_RS05095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS05105	COG5001	Diguanylate cyclase
HVY72_RS05105	COG3300	MHYT domain
HVY72_RS05110	COG2200	EAL domain
HVY72_RS05115	COG0840	transmembrane signaling receptor activity
HVY72_RS05125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVY72_RS05135	COG0745	RESPONSE REGULATOR receiver
HVY72_RS05165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY72_RS05170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY72_RS05175	COG1121	(ABC) transporter
HVY72_RS05195	COG0309	Hydrogenase expression formation protein (HypE)
HVY72_RS05200	COG0409	Hydrogenase expression formation protein
HVY72_RS05205	COG0298	carbon dioxide binding
HVY72_RS05210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY72_RS05215	COG0375	protein maturation
HVY72_RS05225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY72_RS05230	COG0651	ATP synthesis coupled electron transport
HVY72_RS05235	COG0650	Formate hydrogenlyase subunit 4
HVY72_RS05240	COG3261	NADH dehydrogenase
HVY72_RS05240	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY72_RS05245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY72_RS05250	COG3260	NADH ubiquinone oxidoreductase 20
HVY72_RS05260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY72_RS05270	COG2723	6-phospho-beta-galactosidase activity
HVY72_RS05275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS05275	COG1263	PTS System
HVY72_RS05280	COG1609	Transcriptional regulator
HVY72_RS05285	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY72_RS05290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVY72_RS05310	COG0517	IMP dehydrogenase activity
HVY72_RS05310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY72_RS05315	COG1349	DNA-binding transcription factor activity
HVY72_RS05320	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS05335	COG3732	PTS system glucitol sorbitol-specific
HVY72_RS05340	COG3730	PTS system glucitol sorbitol-specific
HVY72_RS05345	COG2951	lytic endotransglycosylase activity
HVY72_RS05350	COG1546	Belongs to the CinA family
HVY72_RS05370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVY72_RS05400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY72_RS05405	COG1238	metal cluster binding
HVY72_RS05425	COG2814	Major facilitator Superfamily
HVY72_RS05430	COG1566	PFAM secretion protein HlyD family protein
HVY72_RS05435	COG1846	Transcriptional regulator
HVY72_RS05445	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY72_RS05450	COG2814	Major facilitator Superfamily
HVY72_RS05460	COG4176	ABC-type proline glycine betaine transport system permease component
HVY72_RS05490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY72_RS05520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY72_RS05525	COG0640	Transcriptional regulator
HVY72_RS05530	COG0401	homolog of Blt101
HVY72_RS05535	COG1652	LysM domain
HVY72_RS05540	COG1802	Transcriptional regulator
HVY72_RS05545	COG1113	amino acid transport
HVY72_RS05550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY72_RS05555	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS05560	COG0579	oxidoreductase
HVY72_RS05605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY72_RS05640	COG0438	transferase activity, transferring glycosyl groups
HVY72_RS05645	COG0297	glycogen (starch) synthase activity
HVY72_RS05645	COG0438	transferase activity, transferring glycosyl groups
HVY72_RS05675	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY72_RS05680	COG1757	Na H antiporter
HVY72_RS05685	COG2169	Transcriptional regulator
HVY72_RS05700	COG3829	transcription factor binding
HVY72_RS05705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY72_RS05710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY72_RS05715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVY72_RS05720	COG2271	Major facilitator Superfamily
HVY72_RS05730	COG2197	response regulator
HVY72_RS05735	COG2205	protein histidine kinase activity
HVY72_RS05735	COG2198	Histidine kinase
HVY72_RS05735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS05735	COG0784	Response regulator, receiver
HVY72_RS05755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY72_RS05760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS05765	COG3065	identical protein binding
HVY72_RS05780	COG3962	Belongs to the TPP enzyme family
HVY72_RS05785	COG0673	inositol 2-dehydrogenase activity
HVY72_RS05800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY72_RS05810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS05820	COG3718	enzyme involved in inositol metabolism
HVY72_RS05825	COG1388	LysM domain
HVY72_RS05825	COG1470	cell adhesion involved in biofilm formation
HVY72_RS05835	COG0582	viral genome integration into host DNA
HVY72_RS05895	COG4725	Belongs to the MT-A70-like family
HVY72_RS05905	COG3645	SOS response
HVY72_RS05905	COG3646	Phage regulatory protein
HVY72_RS05910	COG1403	HNH endonuclease
HVY72_RS05945	COG3179	chitinase
HVY72_RS05985	COG0740	serine-type endopeptidase activity
HVY72_RS06085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY72_RS06110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS06135	COG2867	negative regulation of translational initiation
HVY72_RS06150	COG0497	DNA recombination
HVY72_RS06165	COG4536	flavin adenine dinucleotide binding
HVY72_RS06170	COG4137	Cytochrome C assembly protein
HVY72_RS06175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVY72_RS06210	COG2885	chlorophyll binding
HVY72_RS06215	COG2199	diguanylate cyclase activity
HVY72_RS06230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY72_RS06235	COG1605	Chorismate mutase
HVY72_RS06235	COG0287	Prephenate dehydrogenase
HVY72_RS06240	COG1605	Chorismate mutase
HVY72_RS06240	COG0077	Prephenate dehydratase
HVY72_RS06250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY72_RS06255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY72_RS06270	COG0542	response to heat
HVY72_RS06295	COG0477	Major facilitator Superfamily
HVY72_RS06300	COG5544	Lipoprotein
HVY72_RS06305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY72_RS06315	COG3148	PFAM DTW domain containing protein
HVY72_RS06320	COG3118	belongs to the thioredoxin family
HVY72_RS06325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY72_RS06345	COG0583	DNA-binding transcription factor activity
HVY72_RS06350	COG0513	Belongs to the DEAD box helicase family
HVY72_RS06360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY72_RS06370	COG1595	DNA-templated transcription, initiation
HVY72_RS06380	COG3026	antisigma factor binding
HVY72_RS06385	COG3086	response to oxidative stress
HVY72_RS06395	COG0681	Belongs to the peptidase S26 family
HVY72_RS06415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVY72_RS06425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY72_RS06430	COG1737	Transcriptional regulator
HVY72_RS06435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HVY72_RS06440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS06440	COG1263	PTS System
HVY72_RS06445	COG0560	Phosphoserine phosphatase
HVY72_RS06465	COG2205	protein histidine kinase activity
HVY72_RS06470	COG3170	Tfp pilus assembly protein FimV
HVY72_RS06475	COG2204	response regulator
HVY72_RS06480	COG0347	Belongs to the P(II) protein family
HVY72_RS06485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY72_RS06485	COG1017	nitric oxide dioxygenase activity
HVY72_RS06515	COG4638	Rieske (2fe-2S)
HVY72_RS06520	COG0583	DNA-binding transcription factor activity
HVY72_RS06525	COG1940	carbohydrate kinase activity
HVY72_RS06530	COG0457	Tetratricopeptide repeat
HVY72_RS06535	COG0477	Major facilitator Superfamily
HVY72_RS06535	COG2814	Major facilitator Superfamily
HVY72_RS06545	COG2814	Major facilitator Superfamily
HVY72_RS06550	COG3711	transcriptional antiterminator
HVY72_RS06555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY72_RS06555	COG0517	IMP dehydrogenase activity
HVY72_RS06560	COG1069	ribulokinase activity
HVY72_RS06570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY72_RS06575	COG1129	ABC transporter
HVY72_RS06585	COG3683	transport system, periplasmic component
HVY72_RS06590	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY72_RS06615	COG0822	iron-sulfur transferase activity
HVY72_RS06635	COG0633	Ferredoxin
HVY72_RS06640	COG2975	iron-sulfur cluster assembly
HVY72_RS06655	COG2897	thiosulfate sulfurtransferase activity
HVY72_RS06660	COG2373	Large extracellular alpha-helical protein
HVY72_RS06665	COG4953	penicillin-binding protein 1C
HVY72_RS06695	COG2976	Protein conserved in bacteria
HVY72_RS06715	COG1645	bacterial-type flagellum-dependent swarming motility
HVY72_RS06735	COG1943	Transposase
HVY72_RS06745	COG0517	IMP dehydrogenase activity
HVY72_RS06745	COG0516	GMP reductase activity
HVY72_RS06755	COG0668	transmembrane transport
HVY72_RS06765	COG2200	EAL domain
HVY72_RS06780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVY72_RS06790	COG2723	6-phospho-beta-galactosidase activity
HVY72_RS06800	COG2233	PERMEase
HVY72_RS06810	COG1393	Belongs to the ArsC family
HVY72_RS06815	COG4783	chaperone-mediated protein folding
HVY72_RS06820	COG0628	permease
HVY72_RS06825	COG3366	ferrous iron transmembrane transporter activity
HVY72_RS06830	COG0700	Nucleoside recognition
HVY72_RS06835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY72_RS06840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVY72_RS06845	COG2716	regulation of RNA biosynthetic process
HVY72_RS06855	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVY72_RS06865	COG2321	neutral zinc metallopeptidase
HVY72_RS06875	COG0400	carboxylic ester hydrolase activity
HVY72_RS06890	COG1393	Belongs to the ArsC family
HVY72_RS06900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY72_RS06905	COG3850	Histidine kinase
HVY72_RS06910	COG0493	'glutamate synthase
HVY72_RS06910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY72_RS06920	COG5342	invasion associated locus B
HVY72_RS06925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY72_RS06945	COG4766	ethanolamine catabolic process
HVY72_RS06950	COG4812	Cobalamin adenosyltransferase
HVY72_RS07015	COG2207	Transcriptional regulator
HVY72_RS07025	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY72_RS07045	COG2837	iron assimilation
HVY72_RS07055	COG4150	thiosulfate binding
HVY72_RS07060	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVY72_RS07065	COG4208	sulfate ABC transporter
HVY72_RS07070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVY72_RS07135	COG3530	Putative quorum-sensing-regulated virulence factor
HVY72_RS07140	COG0385	Bile acid
HVY72_RS07145	COG0583	DNA-binding transcription factor activity
HVY72_RS07165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVY72_RS07170	COG2211	Major facilitator Superfamily
HVY72_RS07175	COG0583	DNA-binding transcription factor activity
HVY72_RS07205	COG3415	Transposase
HVY72_RS07210	COG3415	Transposase
HVY72_RS07225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY72_RS07240	COG0667	Aldo Keto reductase
HVY72_RS07245	COG3961	Belongs to the TPP enzyme family
HVY72_RS07265	COG3279	Response regulator of the LytR AlgR family
HVY72_RS07270	COG3275	phosphorelay sensor kinase activity
HVY72_RS07275	COG0436	Aminotransferase
HVY72_RS07290	COG1560	Kdo2-lipid A biosynthetic process
HVY72_RS07320	COG3122	Protein conserved in bacteria
HVY72_RS07325	COG0840	transmembrane signaling receptor activity
HVY72_RS07340	COG2116	formate transmembrane transporter activity
HVY72_RS07350	COG2067	long-chain fatty acid transport protein
HVY72_RS07355	COG3691	Protein conserved in bacteria
HVY72_RS07370	COG2062	phosphohistidine phosphatase, SixA
HVY72_RS07395	COG0730	response to heat
HVY72_RS07400	COG3101	peptidyl-lysine hydroxylation
HVY72_RS07415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY72_RS07435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY72_RS07445	COG0586	Pfam SNARE associated Golgi protein
HVY72_RS07455	COG0285	dihydrofolate synthase activity
HVY72_RS07460	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVY72_RS07465	COG1286	toxin biosynthetic process
HVY72_RS07470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVY72_RS07475	COG0163	prenyltransferase activity
HVY72_RS07485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS07490	COG4215	(ABC) transporter
HVY72_RS07500	COG4598	ABC transporter
HVY72_RS07505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY72_RS07510	COG1090	epimerase
HVY72_RS07515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY72_RS07520	COG0625	glutathione transferase activity
HVY72_RS07525	COG0625	glutathione transferase activity
HVY72_RS07530	COG0622	Phosphoesterase
HVY72_RS07540	COG1288	antiporter activity
HVY72_RS07565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY72_RS07570	COG0471	metal ion transport
HVY72_RS07570	COG0490	domain, Protein
HVY72_RS07580	COG0436	Aminotransferase
HVY72_RS07585	COG0583	DNA-binding transcription factor activity
HVY72_RS07605	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVY72_RS07630	COG0839	Belongs to the complex I subunit 6 family
HVY72_RS07640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY72_RS07645	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY72_RS07655	COG0835	chemotaxis
HVY72_RS07655	COG0784	Response regulator, receiver
HVY72_RS07665	COG2153	protein acetylation
HVY72_RS07670	COG4575	ribosome binding
HVY72_RS07675	COG1169	isochorismate synthase
HVY72_RS07765	COG0247	lactate metabolic process
HVY72_RS07775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY72_RS07780	COG2271	Major facilitator Superfamily
HVY72_RS07785	COG0584	glycerophosphoryl diester phosphodiesterase
HVY72_RS07790	COG0583	DNA-binding transcription factor activity
HVY72_RS07795	COG2814	Major facilitator Superfamily
HVY72_RS07800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY72_RS07825	COG3730	PTS system glucitol sorbitol-specific
HVY72_RS07835	COG3732	PTS system glucitol sorbitol-specific
HVY72_RS07840	COG0673	inositol 2-dehydrogenase activity
HVY72_RS07865	COG0642	Histidine kinase
HVY72_RS07865	COG2198	Histidine kinase
HVY72_RS07870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY72_RS07875	COG1477	protein flavinylation
HVY72_RS07880	COG2169	Transcriptional regulator
HVY72_RS07880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY72_RS07885	COG3145	DNA-N1-methyladenine dioxygenase activity
HVY72_RS07890	COG4615	Cyclic peptide transporter
HVY72_RS07895	COG2239	Acts as a magnesium transporter
HVY72_RS07900	COG0659	secondary active sulfate transmembrane transporter activity
HVY72_RS07915	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY72_RS07915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY72_RS07920	COG3062	negative regulation of establishment of protein localization
HVY72_RS07930	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS07935	COG0348	domain, Protein
HVY72_RS07940	COG3043	anaerobic respiration
HVY72_RS07945	COG3005	denitrification pathway
HVY72_RS07950	COG4133	protoheme IX ABC transporter activity
HVY72_RS07960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY72_RS07965	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY72_RS07975	COG1138	Cytochrome C-type biogenesis protein
HVY72_RS07980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY72_RS07985	COG3088	subunit of a heme lyase
HVY72_RS07985	COG4235	cytochrome complex assembly
HVY72_RS07990	COG2197	response regulator
HVY72_RS08025	COG1061	Type III restriction enzyme res subunit
HVY72_RS08030	COG1187	pseudouridine synthase activity
HVY72_RS08035	COG2814	Major facilitator Superfamily
HVY72_RS08045	COG4172	Belongs to the ABC transporter superfamily
HVY72_RS08050	COG4239	(ABC) transporter, permease
HVY72_RS08055	COG4174	ABC transporter (Permease)
HVY72_RS08060	COG4166	transmembrane transport
HVY72_RS08065	COG2200	EAL domain
HVY72_RS08070	COG0791	NLP P60 protein
HVY72_RS08075	COG0671	phosphoesterase, PA-phosphatase related
HVY72_RS08080	COG0523	cobalamin synthesis protein
HVY72_RS08085	COG0246	Mannitol dehydrogenase
HVY72_RS08090	COG1312	Catalyzes the dehydration of D-mannonate
HVY72_RS08095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY72_RS08100	COG3005	denitrification pathway
HVY72_RS08110	COG3381	protein complex oligomerization
HVY72_RS08135	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY72_RS08140	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVY72_RS08140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS08140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS08145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY72_RS08155	COG0583	DNA-binding transcription factor activity
HVY72_RS08165	COG2855	membrane
HVY72_RS08170	COG0583	DNA-binding transcription factor activity
HVY72_RS08175	COG0833	amino acid
HVY72_RS08180	COG4771	TonB-dependent receptor
HVY72_RS08185	COG2271	Major facilitator Superfamily
HVY72_RS08190	COG0560	Phosphoserine phosphatase
HVY72_RS08195	COG1760	l-serine dehydratase
HVY72_RS08215	COG2311	Membrane
HVY72_RS08230	COG1129	ABC transporter
HVY72_RS08245	COG2949	membrane
HVY72_RS08255	COG1346	cytolysis
HVY72_RS08270	COG2271	Major facilitator Superfamily
HVY72_RS08285	COG0625	glutathione transferase activity
HVY72_RS08290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY72_RS08295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY72_RS08310	COG0586	Pfam SNARE associated Golgi protein
HVY72_RS08320	COG1686	Belongs to the peptidase S11 family
HVY72_RS08325	COG0277	FAD linked oxidase domain protein
HVY72_RS08330	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY72_RS08335	COG1732	Glycine betaine
HVY72_RS08340	COG1174	glycine betaine transport
HVY72_RS08345	COG1125	glycine betaine transport
HVY72_RS08350	COG1174	glycine betaine transport
HVY72_RS08360	COG0789	Transcriptional regulator
HVY72_RS08365	COG3275	phosphorelay sensor kinase activity
HVY72_RS08375	COG4807	Protein conserved in bacteria
HVY72_RS08380	COG4808	Protein conserved in bacteria
HVY72_RS08390	COG0489	protein tyrosine kinase activity
HVY72_RS08405	COG3121	Chaperone
HVY72_RS08410	COG3188	usher protein
HVY72_RS08420	COG5455	response to cobalt ion
HVY72_RS08430	COG0351	phosphomethylpyrimidine kinase
HVY72_RS08435	COG2188	Transcriptional regulator
HVY72_RS08440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS08445	COG1397	ADP-ribosylglycohydrolase
HVY72_RS08450	COG2211	Major facilitator Superfamily
HVY72_RS08455	COG1830	Aldolase
HVY72_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS08470	COG4160	amino acid transport
HVY72_RS08475	COG4215	(ABC) transporter
HVY72_RS08480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS08485	COG1126	abc transporter atp-binding protein
HVY72_RS08510	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY72_RS08515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY72_RS08520	COG0702	epimerase
HVY72_RS08525	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVY72_RS08530	COG0028	Belongs to the TPP enzyme family
HVY72_RS08540	COG4529	Protein conserved in bacteria
HVY72_RS08545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY72_RS08555	COG2431	L-lysine efflux transmembrane transporter activity
HVY72_RS08565	COG3593	DNA synthesis involved in DNA repair
HVY72_RS08570	COG2990	Protein conserved in bacteria
HVY72_RS08575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS08585	COG1278	Cold shock
HVY72_RS08595	COG0542	response to heat
HVY72_RS08600	COG0826	peptidase U32
HVY72_RS08610	COG0745	RESPONSE REGULATOR receiver
HVY72_RS08615	COG2205	protein histidine kinase activity
HVY72_RS08645	COG0443	Heat shock 70 kDa protein
HVY72_RS08650	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVY72_RS08655	COG5002	protein histidine kinase activity
HVY72_RS08655	COG3447	MASE1 domain protein
HVY72_RS08655	COG5001	Diguanylate cyclase
HVY72_RS08670	COG2982	Protein involved in outer membrane biogenesis
HVY72_RS08675	COG1253	flavin adenine dinucleotide binding
HVY72_RS08690	COG0489	protein tyrosine kinase activity
HVY72_RS08690	COG3206	protein involved in exopolysaccharide biosynthesis
HVY72_RS08695	COG0463	Glycosyl transferase, family 2
HVY72_RS08700	COG1045	serine acetyltransferase
HVY72_RS08705	COG0438	transferase activity, transferring glycosyl groups
HVY72_RS08715	COG1216	Glycosyl transferase, family 2
HVY72_RS08720	COG0110	maltose O-acetyltransferase activity
HVY72_RS08725	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVY72_RS08730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY72_RS08735	COG1051	belongs to the nudix hydrolase family
HVY72_RS08740	COG0297	glycogen (starch) synthase activity
HVY72_RS08750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY72_RS08755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY72_RS08760	COG2244	polysaccharide biosynthetic process
HVY72_RS08765	COG2327	Polysaccharide pyruvyl transferase
HVY72_RS08790	COG1216	Glycosyl transferase, family 2
HVY72_RS08810	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVY72_RS08815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY72_RS08820	COG1051	belongs to the nudix hydrolase family
HVY72_RS08830	COG1216	Glycosyl transferase, family 2
HVY72_RS08835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY72_RS08840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVY72_RS08855	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY72_RS08875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVY72_RS08905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY72_RS08910	COG0583	DNA-binding transcription factor activity
HVY72_RS08920	COG0531	amino acid
HVY72_RS08925	COG2925	Exonuclease
HVY72_RS08955	COG1289	transmembrane transporter activity
HVY72_RS08990	COG4656	Part of a membrane complex involved in electron transport
HVY72_RS09000	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS09010	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HVY72_RS09180	COG1376	ErfK ybiS ycfS ynhG family protein
HVY72_RS09185	COG3842	ATPase activity
HVY72_RS09190	COG1178	ABC-type Fe3 transport system permease component
HVY72_RS09195	COG1840	ABC-type Fe3 transport system, periplasmic component
HVY72_RS09215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY72_RS09220	COG1418	mRNA catabolic process
HVY72_RS09225	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVY72_RS09230	COG3727	T/G mismatch-specific endonuclease activity
HVY72_RS09235	COG0697	spore germination
HVY72_RS09240	COG2354	Protein conserved in bacteria
HVY72_RS09245	COG5475	Uncharacterized small protein (DUF2158)
HVY72_RS09305	COG2882	bacterial-type flagellum organization
HVY72_RS09310	COG1157	protein secretion by the type III secretion system
HVY72_RS09335	COG0582	viral genome integration into host DNA
HVY72_RS09380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HVY72_RS09380	COG2755	lipolytic protein G-D-S-L family
HVY72_RS09385	COG0425	Belongs to the sulfur carrier protein TusA family
HVY72_RS09400	COG0366	Alpha amylase catalytic
HVY72_RS09435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS09445	COG0765	amino acid transport
HVY72_RS09450	COG1126	abc transporter atp-binding protein
HVY72_RS09455	COG2197	response regulator
HVY72_RS09465	COG2197	response regulator
HVY72_RS09570	COG1846	Transcriptional regulator
HVY72_RS09595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVY72_RS09610	COG1403	HNH endonuclease
HVY72_RS09640	COG3179	chitinase
HVY72_RS09685	COG4626	Terminase
HVY72_RS09685	COG1802	Transcriptional regulator
HVY72_RS09690	COG4695	Portal protein
HVY72_RS09695	COG0740	serine-type endopeptidase activity
HVY72_RS09780	COG0463	Glycosyl transferase, family 2
HVY72_RS09785	COG2246	polysaccharide biosynthetic process
HVY72_RS09810	COG1305	Transglutaminase-like
HVY72_RS09820	COG2608	mercury ion transmembrane transporter activity
HVY72_RS09825	COG3012	SEC-C Motif Domain Protein
HVY72_RS09825	COG3318	Belongs to the UPF0149 family
HVY72_RS09830	COG0814	amino acid
HVY72_RS09840	COG1528	Iron-storage protein
HVY72_RS09855	COG0477	Major facilitator Superfamily
HVY72_RS09865	COG1528	Iron-storage protein
HVY72_RS09875	COG1879	ABC-type sugar transport system periplasmic component
HVY72_RS09880	COG1129	ABC transporter
HVY72_RS09885	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY72_RS09900	COG0589	response to stress
HVY72_RS09930	COG0835	chemotaxis
HVY72_RS09935	COG1301	dicarboxylic acid transport
HVY72_RS09945	COG0840	transmembrane signaling receptor activity
HVY72_RS09960	COG0745	RESPONSE REGULATOR receiver
HVY72_RS09985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HVY72_RS10000	COG3102	Protein conserved in bacteria
HVY72_RS10020	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVY72_RS10025	COG1801	Protein of unknown function DUF72
HVY72_RS10030	COG1335	isochorismatase
HVY72_RS10040	COG0494	nUDIX hydrolase
HVY72_RS10065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY72_RS10075	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVY72_RS10080	COG0739	heme binding
HVY72_RS10085	COG1560	Kdo2-lipid A biosynthetic process
HVY72_RS10095	COG1737	Transcriptional regulator
HVY72_RS10100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVY72_RS10105	COG0129	dihydroxy-acid dehydratase activity
HVY72_RS10110	COG0800	Aldolase
HVY72_RS10120	COG3141	response to X-ray
HVY72_RS10130	COG2979	Protein of unknown function (DUF533)
HVY72_RS10135	COG1770	oligopeptidase
HVY72_RS10140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY72_RS10145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY72_RS10155	COG2372	response to copper ion
HVY72_RS10160	COG1276	copper resistance
HVY72_RS10170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY72_RS10190	COG3008	intermembrane lipid transfer
HVY72_RS10195	COG2995	paraquat-inducible protein a
HVY72_RS10200	COG1956	GAF domain-containing protein
HVY72_RS10220	COG2814	Major facilitator Superfamily
HVY72_RS10225	COG1414	Transcriptional regulator
HVY72_RS10255	COG0768	penicillin binding
HVY72_RS10260	COG2226	methyltransferase
HVY72_RS10275	COG3716	PTS system mannose fructose sorbose family IID component
HVY72_RS10280	COG3715	PTS system
HVY72_RS10285	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS10285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS10290	COG1253	flavin adenine dinucleotide binding
HVY72_RS10295	COG2200	EAL domain
HVY72_RS10300	COG1760	l-serine dehydratase
HVY72_RS10320	COG0251	oxidation-reduction process
HVY72_RS10325	COG1199	ATP-dependent helicase activity
HVY72_RS10330	COG1214	PFAM Peptidase M22, glycoprotease
HVY72_RS10335	COG3065	identical protein binding
HVY72_RS10340	COG0318	PFAM AMP-dependent synthetase and ligase
HVY72_RS10345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVY72_RS10350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY72_RS10355	COG4638	Rieske (2fe-2S)
HVY72_RS10365	COG0473	3-isopropylmalate dehydrogenase activity
HVY72_RS10370	COG0583	DNA-binding transcription factor activity
HVY72_RS10380	COG2894	cell division
HVY72_RS10395	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY72_RS10425	COG2719	SpoVR family
HVY72_RS10435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY72_RS10445	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVY72_RS10470	COG0157	Belongs to the NadC ModD family
HVY72_RS10475	COG0500	methyltransferase
HVY72_RS10480	COG1120	ATPase activity
HVY72_RS10485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY72_RS10490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY72_RS10505	COG1461	Dihydroxyacetone kinase
HVY72_RS10510	COG2376	Dihydroxyacetone kinase
HVY72_RS10525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVY72_RS10550	COG0789	Transcriptional regulator
HVY72_RS10555	COG2200	EAL domain
HVY72_RS10600	COG3618	amidohydrolase
HVY72_RS10605	COG3775	system Galactitol-specific IIC component
HVY72_RS10615	COG4948	Mandelate Racemase Muconate Lactonizing
HVY72_RS10620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY72_RS10625	COG1454	alcohol dehydrogenase
HVY72_RS10655	COG0012	GTP binding
HVY72_RS10670	COG0527	aspartate kinase activity
HVY72_RS10675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY72_RS10680	COG0076	glutamate decarboxylase activity
HVY72_RS10685	COG0659	secondary active sulfate transmembrane transporter activity
HVY72_RS10715	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY72_RS10720	COG3094	Invasion gene expression up-regulator, SirB
HVY72_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS10740	COG1309	transcriptional regulator
HVY72_RS10745	COG1228	amidohydrolase
HVY72_RS10750	COG0387	Pfam Sodium calcium exchanger
HVY72_RS10755	COG4572	Cation transport regulator
HVY72_RS10760	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVY72_RS10770	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVY72_RS10775	COG4932	domain protein
HVY72_RS10780	COG2197	response regulator
HVY72_RS10785	COG3850	Histidine kinase
HVY72_RS10790	COG2223	nitrite transmembrane transporter activity
HVY72_RS10795	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY72_RS10800	COG1140	nitrate reductase beta subunit
HVY72_RS10805	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY72_RS10810	COG2181	nitrate reductase activity
HVY72_RS10830	COG0788	formyltetrahydrofolate deformylase activity
HVY72_RS10840	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVY72_RS10845	COG0745	RESPONSE REGULATOR receiver
HVY72_RS10850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY72_RS10860	COG1435	thymidine kinase activity
HVY72_RS10865	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS10865	COG1454	alcohol dehydrogenase
HVY72_RS10870	COG2095	MarC family integral membrane protein
HVY72_RS10890	COG0444	Belongs to the ABC transporter superfamily
HVY72_RS10900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY72_RS10920	COG1045	serine acetyltransferase
HVY72_RS10925	COG2755	lipolytic protein G-D-S-L family
HVY72_RS10925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HVY72_RS10930	COG2350	Protein conserved in bacteria
HVY72_RS10955	COG3047	cAMP biosynthetic process
HVY72_RS10960	COG0217	transcriptional regulatory protein
HVY72_RS10970	COG3706	GGDEF domain
HVY72_RS11010	COG0009	L-threonylcarbamoyladenylate synthase
HVY72_RS11015	COG1187	pseudouridine synthase activity
HVY72_RS11025	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS11030	COG0616	signal peptide processing
HVY72_RS11045	COG0583	DNA-binding transcription factor activity
HVY72_RS11060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY72_RS11070	COG0671	phosphoesterase, PA-phosphatase related
HVY72_RS11075	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVY72_RS11080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVY72_RS11090	COG0023	Translation Initiation Factor
HVY72_RS11100	COG1349	DNA-binding transcription factor activity
HVY72_RS11110	COG5001	Diguanylate cyclase
HVY72_RS11120	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY72_RS11120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY72_RS11125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVY72_RS11145	COG4171	peptide transport system, permease
HVY72_RS11160	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY72_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS11175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY72_RS11180	COG1842	Phage shock protein A
HVY72_RS11190	COG1983	PspC domain protein
HVY72_RS11200	COG0366	Alpha amylase catalytic
HVY72_RS11205	COG1653	transport
HVY72_RS11210	COG1175	transmembrane transport
HVY72_RS11215	COG0395	ABC-type sugar transport system, permease component
HVY72_RS11220	COG1063	alcohol dehydrogenase
HVY72_RS11225	COG1082	Xylose isomerase domain protein TIM barrel
HVY72_RS11230	COG0673	inositol 2-dehydrogenase activity
HVY72_RS11235	COG1554	hydrolase, family 65, central catalytic
HVY72_RS11240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY72_RS11245	COG3842	ATPase activity
HVY72_RS11255	COG1609	Transcriptional regulator
HVY72_RS11260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY72_RS11265	COG3106	COG3106 Predicted ATPase
HVY72_RS11280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVY72_RS11285	COG4948	Mandelate Racemase Muconate Lactonizing
HVY72_RS11290	COG2866	Carboxypeptidase
HVY72_RS11295	COG4166	transmembrane transport
HVY72_RS11315	COG1349	DNA-binding transcription factor activity
HVY72_RS11320	COG0346	lactoylglutathione lyase activity
HVY72_RS11335	COG1064	alcohol dehydrogenase
HVY72_RS11340	COG0668	transmembrane transport
HVY72_RS11345	COG3182	Iron-regulated membrane protein
HVY72_RS11365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY72_RS11370	COG2840	Smr protein MutS2
HVY72_RS11375	COG3706	GGDEF domain
HVY72_RS11385	COG0840	transmembrane signaling receptor activity
HVY72_RS11395	COG0513	Belongs to the DEAD box helicase family
HVY72_RS11420	COG0589	response to stress
HVY72_RS11430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY72_RS11435	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVY72_RS11435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY72_RS11435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVY72_RS11435	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVY72_RS11440	COG3042	response to heat
HVY72_RS11445	COG3187	Heat shock protein
HVY72_RS11450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY72_RS11455	COG2911	Protein conserved in bacteria
HVY72_RS11465	COG3784	Protein of unknown function (DUF1318)
HVY72_RS11480	COG1643	Atp-dependent helicase
HVY72_RS11485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY72_RS11490	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS11495	COG2755	lipolytic protein G-D-S-L family
HVY72_RS11495	COG0657	acetylesterase activity
HVY72_RS11500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY72_RS11505	COG3038	cytochrome b561
HVY72_RS11510	COG0697	spore germination
HVY72_RS11520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVY72_RS11550	COG0840	transmembrane signaling receptor activity
HVY72_RS11555	COG0583	DNA-binding transcription factor activity
HVY72_RS11560	COG1227	inorganic diphosphatase activity
HVY72_RS11565	COG5383	Protein conserved in bacteria
HVY72_RS11575	COG2841	Protein conserved in bacteria
HVY72_RS11585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY72_RS11590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY72_RS11595	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVY72_RS11600	COG0500	methyltransferase
HVY72_RS11620	COG3135	benzoate transporter
HVY72_RS11625	COG1396	sequence-specific DNA binding
HVY72_RS11630	COG0826	peptidase U32
HVY72_RS11645	COG1294	oxidase, subunit
HVY72_RS11650	COG1271	oxidase subunit
HVY72_RS11670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY72_RS11675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY72_RS11680	COG3842	ATPase activity
HVY72_RS11685	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY72_RS11690	COG1177	transmembrane transport
HVY72_RS11700	COG2814	Major facilitator Superfamily
HVY72_RS11705	COG2207	Transcriptional regulator
HVY72_RS11735	COG0747	negative chemotaxis
HVY72_RS11745	COG3238	Protein conserved in bacteria
HVY72_RS11750	COG1247	-acetyltransferase
HVY72_RS11760	COG2130	NADP-dependent
HVY72_RS11780	COG0840	transmembrane signaling receptor activity
HVY72_RS11785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY72_RS11790	COG1473	amidohydrolase
HVY72_RS11795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY72_RS11800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HVY72_RS11815	COG1126	abc transporter atp-binding protein
HVY72_RS11820	COG3321	synthase
HVY72_RS11820	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS11820	COG0604	alcohol dehydrogenase
HVY72_RS11830	COG0625	glutathione transferase activity
HVY72_RS11840	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY72_RS11845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY72_RS11850	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVY72_RS11855	COG0384	phenazine biosynthesis protein PhzF
HVY72_RS11860	COG2181	nitrate reductase activity
HVY72_RS11865	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY72_RS11870	COG1140	nitrate reductase beta subunit
HVY72_RS11875	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY72_RS11880	COG2223	nitrite transmembrane transporter activity
HVY72_RS11915	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS11920	COG2864	formate dehydrogenase
HVY72_RS11930	COG3093	addiction module antidote protein HigA
HVY72_RS11940	COG0488	(ABC) transporter
HVY72_RS11960	COG1764	response to oxidative stress
HVY72_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS11970	COG2610	gluconate transmembrane transporter activity
HVY72_RS11975	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY72_RS11985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY72_RS11990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY72_RS12000	COG4608	Belongs to the ABC transporter superfamily
HVY72_RS12005	COG0444	Belongs to the ABC transporter superfamily
HVY72_RS12010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY72_RS12015	COG0601	transmembrane transport
HVY72_RS12020	COG0747	negative chemotaxis
HVY72_RS12025	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HVY72_RS12040	COG0840	transmembrane signaling receptor activity
HVY72_RS12055	COG1649	PFAM Uncharacterised BCR, COG1649
HVY72_RS12060	COG4628	conserved protein (DUF2132)
HVY72_RS12085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY72_RS12095	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY72_RS12125	COG3781	membrane
HVY72_RS12150	COG0840	transmembrane signaling receptor activity
HVY72_RS12155	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS12160	COG0583	DNA-binding transcription factor activity
HVY72_RS12175	COG1846	Transcriptional regulator
HVY72_RS12190	COG0697	spore germination
HVY72_RS12195	COG2814	Major facilitator Superfamily
HVY72_RS12205	COG1122	ATPase activity
HVY72_RS12245	COG4221	oxidoreductase activity
HVY72_RS12250	COG1802	Transcriptional regulator
HVY72_RS12260	COG0246	Mannitol dehydrogenase
HVY72_RS12270	COG4948	Mandelate Racemase Muconate Lactonizing
HVY72_RS12285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY72_RS12305	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS12310	COG3302	dmso reductase anchor subunit
HVY72_RS12315	COG3381	protein complex oligomerization
HVY72_RS12325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY72_RS12330	COG1940	carbohydrate kinase activity
HVY72_RS12335	COG0583	DNA-binding transcription factor activity
HVY72_RS12340	COG2814	Major facilitator Superfamily
HVY72_RS12350	COG5002	protein histidine kinase activity
HVY72_RS12355	COG0745	RESPONSE REGULATOR receiver
HVY72_RS12370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HVY72_RS12380	COG3591	Belongs to the peptidase S1B family
HVY72_RS12395	COG0628	permease
HVY72_RS12400	COG2814	Major facilitator Superfamily
HVY72_RS12405	COG0656	L-ascorbic acid biosynthetic process
HVY72_RS12410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVY72_RS12415	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVY72_RS12425	COG0531	amino acid
HVY72_RS12435	COG3136	membrane protein required for alginate biosynthesis
HVY72_RS12440	COG0745	RESPONSE REGULATOR receiver
HVY72_RS12445	COG1823	symporter activity
HVY72_RS12450	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY72_RS12460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY72_RS12475	COG2205	protein histidine kinase activity
HVY72_RS12490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS12490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS12500	COG5339	Protein conserved in bacteria
HVY72_RS12505	COG1609	Transcriptional regulator
HVY72_RS12510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS12510	COG1263	PTS System
HVY72_RS12515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY72_RS12535	COG0673	inositol 2-dehydrogenase activity
HVY72_RS12585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVY72_RS12595	COG0625	glutathione transferase activity
HVY72_RS12600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVY72_RS12615	COG3895	Periplasmic Protein
HVY72_RS12640	COG1566	PFAM secretion protein HlyD family protein
HVY72_RS12655	COG4989	oxidoreductase activity
HVY72_RS12660	COG3313	Fe-S protein
HVY72_RS12665	COG1309	transcriptional regulator
HVY72_RS12670	COG1902	pentaerythritol trinitrate reductase activity
HVY72_RS12675	COG0346	lactoylglutathione lyase activity
HVY72_RS12685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVY72_RS12690	COG0791	NLP P60 protein
HVY72_RS12695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY72_RS12700	COG2814	Major facilitator Superfamily
HVY72_RS12715	COG0583	DNA-binding transcription factor activity
HVY72_RS12720	COG2814	Major facilitator Superfamily
HVY72_RS12725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY72_RS12730	COG0307	riboflavin synthase, alpha
HVY72_RS12740	COG0564	pseudouridine synthase activity
HVY72_RS12775	COG3300	MHYT domain
HVY72_RS12775	COG5001	Diguanylate cyclase
HVY72_RS12780	COG3272	Protein of unknown function (DUF1722)
HVY72_RS12795	COG0628	permease
HVY72_RS12820	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY72_RS12830	COG0583	DNA-binding transcription factor activity
HVY72_RS12850	COG2076	Multidrug Resistance protein
HVY72_RS12860	COG0386	Belongs to the glutathione peroxidase family
HVY72_RS12880	COG1120	ATPase activity
HVY72_RS12885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY72_RS12890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY72_RS12895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY72_RS12910	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HVY72_RS12920	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS12935	COG1113	amino acid transport
HVY72_RS12940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY72_RS12945	COG0129	dihydroxy-acid dehydratase activity
HVY72_RS12950	COG2271	Major facilitator Superfamily
HVY72_RS12955	COG0800	Aldolase
HVY72_RS12960	COG3734	2-keto-3-deoxy-galactonokinase
HVY72_RS12980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS12995	COG0765	amino acid transport
HVY72_RS13005	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HVY72_RS13010	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS13020	COG2414	aldehyde ferredoxin oxidoreductase
HVY72_RS13025	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS13060	COG1464	Belongs to the NlpA lipoprotein family
HVY72_RS13065	COG2011	ABC-type metal ion transport system permease component
HVY72_RS13085	COG1376	ErfK ybiS ycfS ynhG family protein
HVY72_RS13100	COG0719	Fe-S assembly protein
HVY72_RS13105	COG0396	ATPase activity
HVY72_RS13110	COG0719	Fe-S assembly protein
HVY72_RS13115	COG0316	Belongs to the HesB IscA family
HVY72_RS13120	COG0583	DNA-binding transcription factor activity
HVY72_RS13135	COG2050	protein possibly involved in aromatic compounds catabolism
HVY72_RS13140	COG0247	lactate metabolic process
HVY72_RS13140	COG0277	FAD linked oxidase domain protein
HVY72_RS13145	COG0628	permease
HVY72_RS13195	COG0738	Major facilitator superfamily
HVY72_RS13200	COG2271	Major facilitator Superfamily
HVY72_RS13215	COG4670	ketone body catabolic process
HVY72_RS13220	COG1960	acyl-CoA dehydrogenase activity
HVY72_RS13225	COG1917	Cupin 2, conserved barrel domain protein
HVY72_RS13225	COG2207	Transcriptional regulator
HVY72_RS13230	COG2086	electron transfer activity
HVY72_RS13235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVY72_RS13240	COG0644	oxidoreductase
HVY72_RS13245	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY72_RS13250	COG0318	PFAM AMP-dependent synthetase and ligase
HVY72_RS13255	COG0574	Belongs to the PEP-utilizing enzyme family
HVY72_RS13255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY72_RS13265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY72_RS13270	COG4256	Hemin uptake protein
HVY72_RS13275	COG4771	TonB-dependent receptor
HVY72_RS13280	COG3720	iron ion transport
HVY72_RS13285	COG4558	Periplasmic binding protein
HVY72_RS13290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY72_RS13310	COG0791	NLP P60 protein
HVY72_RS13320	COG0386	Belongs to the glutathione peroxidase family
HVY72_RS13355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HVY72_RS13375	COG3137	Salt-induced outer membrane protein
HVY72_RS13380	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY72_RS13385	COG3001	Fructosamine kinase
HVY72_RS13395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY72_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS13405	COG1988	membrane-bound metal-dependent
HVY72_RS13410	COG1823	symporter activity
HVY72_RS13420	COG0753	catalase activity
HVY72_RS13430	COG1486	melibiose metabolic process
HVY72_RS13435	COG2169	Transcriptional regulator
HVY72_RS13435	COG1917	Cupin 2, conserved barrel domain protein
HVY72_RS13440	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY72_RS13445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY72_RS13450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY72_RS13455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY72_RS13465	COG0322	excinuclease ABC activity
HVY72_RS13475	COG3678	ATP-independent chaperone mediated protein folding
HVY72_RS13505	COG0708	Exodeoxyribonuclease III
HVY72_RS13510	COG0398	Pfam SNARE associated Golgi protein
HVY72_RS13515	COG0398	Pfam SNARE associated Golgi protein
HVY72_RS13520	COG4134	Bacterial extracellular solute-binding protein
HVY72_RS13525	COG4135	transport system, permease component
HVY72_RS13530	COG4136	ATPase activity
HVY72_RS13535	COG2897	thiosulfate sulfurtransferase activity
HVY72_RS13540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY72_RS13545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY72_RS13550	COG0494	nUDIX hydrolase
HVY72_RS13565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY72_RS13575	COG0778	Nitroreductase
HVY72_RS13580	COG0616	signal peptide processing
HVY72_RS13595	COG0252	asparaginase activity
HVY72_RS13600	COG1335	isochorismatase
HVY72_RS13605	COG2814	Major facilitator Superfamily
HVY72_RS13610	COG1349	DNA-binding transcription factor activity
HVY72_RS13615	COG0667	Aldo Keto reductase
HVY72_RS13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS13625	COG0191	fructose-bisphosphate aldolase activity
HVY72_RS13630	COG1063	alcohol dehydrogenase
HVY72_RS13635	COG2271	Major facilitator Superfamily
HVY72_RS13640	COG1063	alcohol dehydrogenase
HVY72_RS13655	COG3139	Protein of unknown function (DUF1315)
HVY72_RS13675	COG0656	L-ascorbic acid biosynthetic process
HVY72_RS13690	COG3713	MltA-interacting MipA family protein
HVY72_RS13695	COG2766	serine protein kinase
HVY72_RS13705	COG2199	diguanylate cyclase activity
HVY72_RS13710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY72_RS13720	COG2207	Transcriptional regulator
HVY72_RS13725	COG2807	transmembrane transport
HVY72_RS13730	COG0504	CTP synthase activity
HVY72_RS13735	COG3189	MarR family transcriptional regulator
HVY72_RS13740	COG3042	response to heat
HVY72_RS13745	COG2199	diguanylate cyclase activity
HVY72_RS13745	COG2203	Gaf domain
HVY72_RS13760	COG2261	transglycosylase associated protein
HVY72_RS13765	COG3383	formate dehydrogenase (NAD+) activity
HVY72_RS13780	COG3615	Tellurite resistance protein tehB
HVY72_RS13790	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVY72_RS13800	COG1124	(ABC) transporter
HVY72_RS13810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY72_RS13815	COG0601	transmembrane transport
HVY72_RS13820	COG0747	negative chemotaxis
HVY72_RS13825	COG4771	TonB-dependent receptor
HVY72_RS13840	COG2200	EAL domain
HVY72_RS13860	COG0538	isocitrate dehydrogenase activity
HVY72_RS13865	COG1187	pseudouridine synthase activity
HVY72_RS13890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVY72_RS13895	COG2135	peptidase activity
HVY72_RS13905	COG3272	Protein of unknown function (DUF1722)
HVY72_RS13925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY72_RS13940	COG0300	oxidoreductase activity
HVY72_RS13950	COG0789	Transcriptional regulator
HVY72_RS14035	COG0616	signal peptide processing
HVY72_RS14050	COG1802	Transcriptional regulator
HVY72_RS14050	COG4626	Terminase
HVY72_RS14065	COG3038	cytochrome b561
HVY72_RS14110	COG3772	lysozyme
HVY72_RS14135	COG1403	HNH endonuclease
HVY72_RS14140	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVY72_RS14175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY72_RS14225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY72_RS14235	COG0582	viral genome integration into host DNA
HVY72_RS14250	COG2850	peptidyl-arginine hydroxylation
HVY72_RS14270	COG1177	transmembrane transport
HVY72_RS14285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY72_RS14295	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY72_RS14300	COG1136	(ABC) transporter
HVY72_RS14305	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY72_RS14310	COG4763	Acyl-transferase
HVY72_RS14315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVY72_RS14320	COG1388	LysM domain
HVY72_RS14320	COG1376	ErfK ybiS ycfS ynhG family protein
HVY72_RS14330	COG1309	transcriptional regulator
HVY72_RS14340	COG3134	Outer membrane lipoprotein
HVY72_RS14345	COG1252	NADH dehydrogenase
HVY72_RS14370	COG5633	Lipoprotein
HVY72_RS14375	COG0537	adenosine 5'-monophosphoramidase activity
HVY72_RS14380	COG4773	Receptor
HVY72_RS14385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY72_RS14390	COG3327	negative regulation of DNA-templated transcription, initiation
HVY72_RS14395	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVY72_RS14400	COG0183	Belongs to the thiolase family
HVY72_RS14405	COG2050	protein possibly involved in aromatic compounds catabolism
HVY72_RS14410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY72_RS14415	COG1024	Enoyl-CoA hydratase
HVY72_RS14420	COG1024	Enoyl-CoA hydratase
HVY72_RS14425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY72_RS14430	COG2151	metal-sulfur cluster biosynthetic enzyme
HVY72_RS14435	COG3396	Phenylacetate-CoA oxygenase
HVY72_RS14440	COG3460	Phenylacetate-CoA oxygenase
HVY72_RS14445	COG3396	Phenylacetate-CoA oxygenase
HVY72_RS14450	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS14450	COG2030	dehydratase
HVY72_RS14475	COG0534	Mate efflux family protein
HVY72_RS14485	COG0583	DNA-binding transcription factor activity
HVY72_RS14505	COG1595	DNA-templated transcription, initiation
HVY72_RS14510	COG3712	iron ion homeostasis
HVY72_RS14515	COG4772	TonB-dependent receptor
HVY72_RS14520	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HVY72_RS14525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY72_RS14530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY72_RS14535	COG1120	ATPase activity
HVY72_RS14545	COG2814	Major facilitator Superfamily
HVY72_RS14560	COG0477	Major facilitator Superfamily
HVY72_RS14565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVY72_RS14580	COG0084	hydrolase, TatD family'
HVY72_RS14585	COG0470	DNA polymerase III
HVY72_RS14595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVY72_RS14600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY72_RS14605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY72_RS14640	COG1399	metal-binding, possibly nucleic acid-binding protein
HVY72_RS14650	COG0564	pseudouridine synthase activity
HVY72_RS14655	COG1530	ribonuclease E activity
HVY72_RS14660	COG0583	DNA-binding transcription factor activity
HVY72_RS14665	COG2814	Major facilitator Superfamily
HVY72_RS14695	COG4786	Flagellar basal body rod
HVY72_RS14700	COG4787	bacterial-type flagellum-dependent cell motility
HVY72_RS14715	COG1558	bacterial-type flagellum-dependent cell motility
HVY72_RS14755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY72_RS14795	COG3038	cytochrome b561
HVY72_RS14810	COG1560	Kdo2-lipid A biosynthetic process
HVY72_RS14820	COG2199	diguanylate cyclase activity
HVY72_RS14830	COG5645	(Lipo)protein
HVY72_RS14850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY72_RS14905	COG3381	protein complex oligomerization
HVY72_RS14925	COG1702	phosphate starvation-inducible protein PhoH
HVY72_RS14935	COG2822	iron ion transport
HVY72_RS14945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY72_RS14950	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY72_RS14950	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY72_RS14950	COG0506	proline dehydrogenase activity
HVY72_RS14955	COG3755	Protein conserved in bacteria
HVY72_RS14960	COG1309	transcriptional regulator
HVY72_RS14970	COG3729	General stress protein
HVY72_RS14990	COG0640	Transcriptional regulator
HVY72_RS15000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY72_RS15005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY72_RS15005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HVY72_RS15055	COG0813	purine-nucleoside phosphorylase activity
HVY72_RS15065	COG2246	polysaccharide biosynthetic process
HVY72_RS15090	COG0670	Belongs to the BI1 family
HVY72_RS15110	COG1881	PFAM PEBP family protein
HVY72_RS15125	COG1832	CoA-binding protein
HVY72_RS15140	COG0210	DNA helicase
HVY72_RS15145	COG3304	Inner membrane component domain
HVY72_RS15150	COG1289	transmembrane transporter activity
HVY72_RS15155	COG3070	regulator of competence-specific genes
HVY72_RS15175	COG1067	ATP-dependent peptidase activity
HVY72_RS15185	COG3130	regulation of translation
HVY72_RS15190	COG3009	Protein conserved in bacteria
HVY72_RS15195	COG3008	intermembrane lipid transfer
HVY72_RS15195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY72_RS15200	COG2995	paraquat-inducible protein a
HVY72_RS15205	COG0488	(ABC) transporter
HVY72_RS15215	COG0633	Ferredoxin
HVY72_RS15215	COG3217	Mosc domain protein beta barrel domain protein
HVY72_RS15230	COG0431	NADPH-dependent FMN reductase
HVY72_RS15235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY72_RS15255	COG0308	aminopeptidase N
HVY72_RS15275	COG1448	Aminotransferase
HVY72_RS15280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY72_RS15285	COG3108	Peptidase M15
HVY72_RS15290	COG2989	Protein conserved in bacteria
HVY72_RS15300	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVY72_RS15310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVY72_RS15315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY72_RS15320	COG3173	Aminoglycoside phosphotransferase
HVY72_RS15335	COG3214	Protein conserved in bacteria
HVY72_RS15350	COG2333	competence protein COMEC
HVY72_RS15350	COG0658	competence protein
HVY72_RS15355	COG0776	regulation of translation
HVY72_RS15360	COG0539	negative regulation of cytoplasmic translation
HVY72_RS15370	COG0501	Belongs to the peptidase M48B family
HVY72_RS15385	COG2323	membrane
HVY72_RS15390	COG1944	ATP diphosphatase activity
HVY72_RS15395	COG2116	formate transmembrane transporter activity
HVY72_RS15400	COG1882	Formate acetyltransferase
HVY72_RS15405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY72_RS15415	COG0531	amino acid
HVY72_RS15425	COG1335	isochorismatase
HVY72_RS15430	COG3302	dmso reductase anchor subunit
HVY72_RS15435	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS15440	COG0243	molybdopterin cofactor binding
HVY72_RS15450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVY72_RS15460	COG1674	ftsk spoiiie
HVY72_RS15460	COG1178	ABC-type Fe3 transport system permease component
HVY72_RS15470	COG0492	ferredoxin-NADP+ reductase activity
HVY72_RS15475	COG4988	ABC transporter
HVY72_RS15480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVY72_RS15495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HVY72_RS15500	COG0583	DNA-binding transcription factor activity
HVY72_RS15510	COG1335	isochorismatase
HVY72_RS15530	COG1177	transmembrane transport
HVY72_RS15535	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY72_RS15540	COG3842	ATPase activity
HVY72_RS15545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY72_RS15590	COG3226	Transcriptional regulator
HVY72_RS15595	COG0738	Major facilitator superfamily
HVY72_RS15600	COG0561	phosphatase activity
HVY72_RS15610	COG2814	Major facilitator Superfamily
HVY72_RS15615	COG0671	phosphoesterase, PA-phosphatase related
HVY72_RS15620	COG1349	DNA-binding transcription factor activity
HVY72_RS15625	COG1686	Belongs to the peptidase S11 family
HVY72_RS15630	COG0625	glutathione transferase activity
HVY72_RS15635	COG2133	pyrroloquinoline quinone binding
HVY72_RS15645	COG0583	DNA-binding transcription factor activity
HVY72_RS15650	COG0058	SHG alpha-glucan phosphorylase activity
HVY72_RS15675	COG0747	negative chemotaxis
HVY72_RS15685	COG1446	asparaginase
HVY72_RS15695	COG0303	'Molybdopterin
HVY72_RS15700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY72_RS15705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY72_RS15710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY72_RS15715	COG1882	Formate acetyltransferase
HVY72_RS15720	COG0561	phosphatase activity
HVY72_RS15730	COG0488	(ABC) transporter
HVY72_RS15735	COG1376	ErfK ybiS ycfS ynhG family protein
HVY72_RS15740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY72_RS15755	COG2194	sulfuric ester hydrolase activity
HVY72_RS15760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVY72_RS15775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY72_RS15780	COG0765	amino acid transport
HVY72_RS15785	COG1126	abc transporter atp-binding protein
HVY72_RS15790	COG0668	transmembrane transport
HVY72_RS15805	COG4774	siderophore transport
HVY72_RS15815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY72_RS15825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY72_RS15830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY72_RS15840	COG0513	Belongs to the DEAD box helicase family
HVY72_RS15845	COG1309	transcriptional regulator
HVY72_RS15855	COG1131	(ABC) transporter
HVY72_RS15860	COG0842	Transport permease protein
HVY72_RS15865	COG0842	Transport permease protein
HVY72_RS15875	COG3568	Endonuclease Exonuclease Phosphatase
HVY72_RS15880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY72_RS15885	COG0392	lysyltransferase activity
HVY72_RS15890	COG0670	Belongs to the BI1 family
HVY72_RS15895	COG0314	molybdopterin synthase activity
HVY72_RS15900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVY72_RS15910	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY72_RS15935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY72_RS15960	COG1881	PFAM PEBP family protein
HVY72_RS15990	COG4677	pectinesterase activity
HVY72_RS15995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY72_RS16000	COG0471	metal ion transport
HVY72_RS16005	COG2828	Protein conserved in bacteria
HVY72_RS16010	COG0583	DNA-binding transcription factor activity
HVY72_RS16020	COG0561	phosphatase activity
HVY72_RS16030	COG4149	molybdate abc transporter
HVY72_RS16035	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVY72_RS16045	COG3585	molybdate ion transport
HVY72_RS16045	COG2005	Transcriptional regulator
HVY72_RS16050	COG1119	ATPase activity
HVY72_RS16055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVY72_RS16060	COG1085	galactose-1-phosphate uridylyltransferase
HVY72_RS16070	COG2017	converts alpha-aldose to the beta-anomer
HVY72_RS16080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY72_RS16090	COG1230	cation diffusion facilitator family transporter
HVY72_RS16095	COG3201	nicotinamide mononucleotide transporter
HVY72_RS16130	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVY72_RS16135	COG2885	chlorophyll binding
HVY72_RS16145	COG3064	Membrane
HVY72_RS16150	COG0848	biopolymer transport protein
HVY72_RS16155	COG0811	peptide transport
HVY72_RS16160	COG0824	Thioesterase
HVY72_RS16165	COG3790	cyd operon protein YbgE
HVY72_RS16170	COG4890	Cyd operon protein YbgT
HVY72_RS16175	COG1294	oxidase, subunit
HVY72_RS16180	COG1271	oxidase subunit
HVY72_RS16185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY72_RS16195	COG4865	methylaspartate mutase activity
HVY72_RS16200	COG3799	methylaspartate ammonia-lyase activity
HVY72_RS16215	COG1301	dicarboxylic acid transport
HVY72_RS16225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS16225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS16235	COG0583	DNA-binding transcription factor activity
HVY72_RS16240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HVY72_RS16240	COG1648	precorrin-2 dehydrogenase activity
HVY72_RS16250	COG3395	kinase activity
HVY72_RS16255	COG0235	Class ii aldolase
HVY72_RS16260	COG1349	DNA-binding transcription factor activity
HVY72_RS16265	COG3622	Belongs to the hyi family
HVY72_RS16270	COG3246	L-lysine catabolic process to acetate
HVY72_RS16290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY72_RS16300	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY72_RS16305	COG0567	Dehydrogenase, E1 component
HVY72_RS16310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY72_RS16315	COG1053	succinate dehydrogenase
HVY72_RS16320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVY72_RS16325	COG2009	succinate dehydrogenase
HVY72_RS16335	COG3180	Ammonia monooxygenase
HVY72_RS16365	COG1984	allophanate hydrolase subunit 2
HVY72_RS16370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVY72_RS16375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVY72_RS16390	COG3272	Protein of unknown function (DUF1722)
HVY72_RS16420	COG2205	protein histidine kinase activity
HVY72_RS16425	COG0745	RESPONSE REGULATOR receiver
HVY72_RS16430	COG0033	Phosphoglucomutase
HVY72_RS16435	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVY72_RS16440	COG0596	Alpha beta hydrolase
HVY72_RS16450	COG0716	FMN binding
HVY72_RS16460	COG0735	belongs to the Fur family
HVY72_RS16465	COG0583	DNA-binding transcription factor activity
HVY72_RS16470	COG1053	succinate dehydrogenase
HVY72_RS16500	COG2190	(PTS) system
HVY72_RS16500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS16500	COG1263	PTS System
HVY72_RS16510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY72_RS16515	COG1940	carbohydrate kinase activity
HVY72_RS16515	COG1846	Transcriptional regulator
HVY72_RS16520	COG0647	UMP catabolic process
HVY72_RS16525	COG0367	asparagine synthase
HVY72_RS16565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY72_RS16575	COG1702	phosphate starvation-inducible protein PhoH
HVY72_RS16585	COG4535	Mg2 and Co2 transporter CorC
HVY72_RS16600	COG0765	amino acid transport
HVY72_RS16605	COG0765	amino acid transport
HVY72_RS16610	COG1126	abc transporter atp-binding protein
HVY72_RS16620	COG2888	peptidyl-tyrosine sulfation
HVY72_RS16635	COG1466	dna polymerase III delta subunit
HVY72_RS16645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HVY72_RS16655	COG0799	negative regulation of ribosome biogenesis
HVY72_RS16665	COG0768	penicillin binding
HVY72_RS16670	COG0772	Belongs to the SEDS family
HVY72_RS16675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY72_RS16680	COG1686	Belongs to the peptidase S11 family
HVY72_RS16705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY72_RS16725	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY72_RS16730	COG4565	transcriptional regulatory protein
HVY72_RS16735	COG3290	protein histidine kinase activity
HVY72_RS16740	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVY72_RS16750	COG2301	Belongs to the HpcH HpaI aldolase family
HVY72_RS16755	COG3051	citrate lyase alpha subunit
HVY72_RS16770	COG0471	metal ion transport
HVY72_RS16775	COG3719	Belongs to the RNase T2 family
HVY72_RS16790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY72_RS16800	COG3634	alkyl hydroperoxide reductase activity
HVY72_RS16810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY72_RS16815	COG0583	DNA-binding transcription factor activity
HVY72_RS16820	COG3969	phosphoadenosine phosphosulfate
HVY72_RS16825	COG1475	DNA binding
HVY72_RS16830	COG0436	Aminotransferase
HVY72_RS16835	COG0371	Dehydrogenase
HVY72_RS16840	COG2879	small protein
HVY72_RS16845	COG1966	Carbon starvation protein
HVY72_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS16860	COG3433	isochorismatase activity
HVY72_RS16860	COG1535	isochorismatase
HVY72_RS16865	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVY72_RS16870	COG1169	isochorismate synthase
HVY72_RS16875	COG4592	Periplasmic binding protein
HVY72_RS16885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY72_RS16890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY72_RS16895	COG1120	ATPase activity
HVY72_RS16900	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY72_RS16905	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVY72_RS16905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVY72_RS16910	COG3251	PFAM MbtH domain protein
HVY72_RS16915	COG2382	esterase
HVY72_RS16920	COG4771	TonB-dependent receptor
HVY72_RS16960	COG2315	Protein conserved in bacteria
HVY72_RS16970	COG0668	transmembrane transport
HVY72_RS16990	COG2211	Major facilitator Superfamily
HVY72_RS16995	COG1113	amino acid transport
HVY72_RS17020	COG5001	Diguanylate cyclase
HVY72_RS17020	COG3300	MHYT domain
HVY72_RS17035	COG3059	membrane
HVY72_RS17045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY72_RS17050	COG2207	Transcriptional regulator
HVY72_RS17055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY72_RS17060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS17065	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS17070	COG1538	Outer membrane efflux protein
HVY72_RS17075	COG0745	RESPONSE REGULATOR receiver
HVY72_RS17080	COG5002	protein histidine kinase activity
HVY72_RS17095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVY72_RS17095	COG0321	lipoyl(octanoyl) transferase activity
HVY72_RS17100	COG0243	molybdopterin cofactor binding
HVY72_RS17105	COG3005	denitrification pathway
HVY72_RS17125	COG3005	denitrification pathway
HVY72_RS17130	COG0745	RESPONSE REGULATOR receiver
HVY72_RS17135	COG1879	ABC-type sugar transport system periplasmic component
HVY72_RS17140	COG0784	Response regulator, receiver
HVY72_RS17140	COG2198	Histidine kinase
HVY72_RS17140	COG2205	protein histidine kinase activity
HVY72_RS17205	COG2501	S4 domain
HVY72_RS17210	COG1988	membrane-bound metal-dependent
HVY72_RS17220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY72_RS17230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVY72_RS17235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVY72_RS17240	COG0549	Belongs to the carbamate kinase family
HVY72_RS17250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY72_RS17255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY72_RS17260	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY72_RS17265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY72_RS17270	COG3257	ureidoglycine aminohydrolase activity
HVY72_RS17275	COG1929	Belongs to the glycerate kinase type-1 family
HVY72_RS17280	COG2233	PERMEase
HVY72_RS17290	COG1953	Uracil, thiamine, allantoin
HVY72_RS17300	COG2084	Dehydrogenase
HVY72_RS17305	COG3622	Belongs to the hyi family
HVY72_RS17310	COG3960	tartronate-semialdehyde synthase activity
HVY72_RS17330	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HVY72_RS17335	COG2011	ABC-type metal ion transport system permease component
HVY72_RS17345	COG1464	Belongs to the NlpA lipoprotein family
HVY72_RS17350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY72_RS17355	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVY72_RS17360	COG4181	ATPase activity
HVY72_RS17365	COG2755	lipolytic protein G-D-S-L family
HVY72_RS17370	COG0300	oxidoreductase activity
HVY72_RS17375	COG3118	belongs to the thioredoxin family
HVY72_RS17380	COG0390	transport system, permease component
HVY72_RS17385	COG4619	ABC transporter
HVY72_RS17390	COG0330	HflC and HflK could
HVY72_RS17395	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY72_RS17415	COG2217	Heavy metal translocating P-type atpase
HVY72_RS17420	COG3735	TraB family
HVY72_RS17425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY72_RS17435	COG2223	nitrite transmembrane transporter activity
HVY72_RS17440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY72_RS17440	COG4651	solute:proton antiporter activity
HVY72_RS17445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS17490	COG2832	Protein of unknown function (DUF454)
HVY72_RS17495	COG3923	Primosomal replication protein n
HVY72_RS17505	COG1196	nuclear chromosome segregation
HVY72_RS17505	COG3264	Mechanosensitive ion channel
HVY72_RS17510	COG1309	transcriptional regulator
HVY72_RS17515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY72_RS17520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY72_RS17535	COG0110	maltose O-acetyltransferase activity
HVY72_RS17555	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY72_RS17560	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVY72_RS17565	COG2364	Membrane
HVY72_RS17570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY72_RS17590	COG3695	enzyme binding
HVY72_RS17595	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVY72_RS17600	COG1946	Acyl-CoA thioesterase
HVY72_RS17605	COG0004	ammonium transporteR
HVY72_RS17610	COG0347	Belongs to the P(II) protein family
HVY72_RS17615	COG1132	(ABC) transporter
HVY72_RS17620	COG1132	(ABC) transporter
HVY72_RS17625	COG1522	sequence-specific DNA binding
HVY72_RS17640	COG4533	DNA binding
HVY72_RS17650	COG0824	Thioesterase
HVY72_RS17655	COG1555	photosystem II stabilization
HVY72_RS17660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY72_RS17665	COG0776	regulation of translation
HVY72_RS17670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVY72_RS17690	COG0271	Belongs to the BolA IbaG family
HVY72_RS17695	COG3056	Lipoprotein
HVY72_RS17700	COG2223	nitrite transmembrane transporter activity
HVY72_RS17705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVY72_RS17710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVY72_RS17715	COG1845	cytochrome c oxidase, subunit III
HVY72_RS17720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVY72_RS17730	COG2814	Major facilitator Superfamily
HVY72_RS17765	COG0142	geranyltranstransferase activity
HVY72_RS17775	COG0667	Aldo Keto reductase
HVY72_RS17780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVY72_RS17785	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HVY72_RS17800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY72_RS17800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY72_RS17810	COG4238	major outer membrane lipoprotein
HVY72_RS17830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY72_RS17835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY72_RS17840	COG1862	Preprotein translocase
HVY72_RS17860	COG0450	alkyl hydroperoxide reductase
HVY72_RS17865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HVY72_RS17875	COG1335	isochorismatase
HVY72_RS17880	COG0583	DNA-binding transcription factor activity
HVY72_RS17885	COG0366	Alpha amylase catalytic
HVY72_RS17900	COG5002	protein histidine kinase activity
HVY72_RS17910	COG0420	3'-5' exonuclease activity
HVY72_RS17915	COG0419	ATPase involved in DNA repair
HVY72_RS17920	COG2814	Major facilitator Superfamily
HVY72_RS17925	COG1940	carbohydrate kinase activity
HVY72_RS17940	COG4126	flavin adenine dinucleotide binding
HVY72_RS17960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVY72_RS17965	COG3706	GGDEF domain
HVY72_RS17975	COG1785	Belongs to the alkaline phosphatase family
HVY72_RS17990	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY72_RS18010	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVY72_RS18015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY72_RS18020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY72_RS18025	COG3468	outer membrane autotransporter barrel domain protein
HVY72_RS18030	COG0113	porphobilinogen synthase activity
HVY72_RS18035	COG2175	clavaminate synthase activity
HVY72_RS18040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY72_RS18045	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HVY72_RS18050	COG4521	taurine ABC transporter
HVY72_RS18065	COG2271	Major facilitator Superfamily
HVY72_RS18070	COG1840	ABC-type Fe3 transport system, periplasmic component
HVY72_RS18080	COG3842	ATPase activity
HVY72_RS18100	COG2040	homocysteine
HVY72_RS18105	COG0833	amino acid
HVY72_RS18110	COG2814	Major facilitator Superfamily
HVY72_RS18145	COG1414	Transcriptional regulator
HVY72_RS18170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVY72_RS18185	COG1609	Transcriptional regulator
HVY72_RS18200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY72_RS18205	COG2079	MmgE PrpD family protein
HVY72_RS18210	COG0372	Belongs to the citrate synthase family
HVY72_RS18220	COG3829	transcription factor binding
HVY72_RS18230	COG1280	lysine exporter protein (LysE YggA)
HVY72_RS18235	COG3706	GGDEF domain
HVY72_RS18240	COG0348	domain, Protein
HVY72_RS18260	COG0583	DNA-binding transcription factor activity
HVY72_RS18280	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY72_RS18285	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY72_RS18295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVY72_RS18300	COG0693	protein deglycase activity
HVY72_RS18305	COG2957	Belongs to the agmatine deiminase family
HVY72_RS18315	COG0531	amino acid
HVY72_RS18320	COG0174	glutamine synthetase
HVY72_RS18325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVY72_RS18330	COG1396	sequence-specific DNA binding
HVY72_RS18330	COG1917	Cupin 2, conserved barrel domain protein
HVY72_RS18335	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS18340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVY72_RS18355	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVY72_RS18360	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY72_RS18365	COG1999	signal sequence binding
HVY72_RS18370	COG1773	rubredoxin
HVY72_RS18375	COG1271	oxidase subunit
HVY72_RS18380	COG1294	oxidase, subunit
HVY72_RS18405	COG1609	Transcriptional regulator
HVY72_RS18410	COG1757	Na H antiporter
HVY72_RS18415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY72_RS18425	COG2020	methyltransferase activity
HVY72_RS18430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY72_RS18460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY72_RS18470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HVY72_RS18495	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY72_RS18505	COG3034	peptidoglycan biosynthetic process
HVY72_RS18510	COG0121	glutamine amidotransferase
HVY72_RS18520	COG1960	acyl-CoA dehydrogenase activity
HVY72_RS18525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY72_RS18535	COG2200	EAL domain
HVY72_RS18550	COG3539	Fimbrial protein
HVY72_RS18560	COG3121	Chaperone
HVY72_RS18565	COG3188	usher protein
HVY72_RS18575	COG3539	Fimbrial protein
HVY72_RS18580	COG0745	RESPONSE REGULATOR receiver
HVY72_RS18595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY72_RS18605	COG2226	methyltransferase
HVY72_RS18615	COG1388	LysM domain
HVY72_RS18615	COG0741	lytic transglycosylase activity
HVY72_RS18620	COG2226	methyltransferase
HVY72_RS18630	COG2814	Major facilitator Superfamily
HVY72_RS18635	COG0583	DNA-binding transcription factor activity
HVY72_RS18670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY72_RS18680	COG2011	ABC-type metal ion transport system permease component
HVY72_RS18685	COG1464	Belongs to the NlpA lipoprotein family
HVY72_RS18695	COG1720	tRNA m6t6A37 methyltransferase activity
HVY72_RS18705	COG3015	lipoprotein NlpE involved in copper resistance
HVY72_RS18710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY72_RS18725	COG4568	rho-dependent transcription termination
HVY72_RS18735	COG0346	lactoylglutathione lyase activity
HVY72_RS18740	COG1982	Orn Lys Arg decarboxylase major
HVY72_RS18775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVY72_RS18780	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVY72_RS18795	COG0575	Belongs to the CDS family
HVY72_RS18805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVY72_RS18850	COG3835	regulator
HVY72_RS18875	COG2860	membrane
HVY72_RS18905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY72_RS18910	COG1120	ATPase activity
HVY72_RS18915	COG4774	siderophore transport
HVY72_RS18920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY72_RS18925	COG1643	Atp-dependent helicase
HVY72_RS18930	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVY72_RS18950	COG0617	tRNA 3'-terminal CCA addition
HVY72_RS18955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVY72_RS18970	COG3121	Chaperone
HVY72_RS18975	COG3188	usher protein
HVY72_RS18995	COG3539	Fimbrial protein
HVY72_RS19000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HVY72_RS19015	COG0726	polysaccharide deacetylase
HVY72_RS19020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS19025	COG0842	Transport permease protein
HVY72_RS19030	COG1131	(ABC) transporter
HVY72_RS19035	COG0288	reversible hydration of carbon dioxide
HVY72_RS19040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVY72_RS19090	COG3064	Membrane
HVY72_RS19100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY72_RS19105	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY72_RS19110	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVY72_RS19125	COG2211	Major facilitator Superfamily
HVY72_RS19130	COG3940	Belongs to the glycosyl hydrolase 43 family
HVY72_RS19135	COG3725	Membrane protein required for beta-lactamase induction
HVY72_RS19150	COG4969	Belongs to the N-Me-Phe pilin family
HVY72_RS19155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY72_RS19160	COG1459	type II secretion system
HVY72_RS19170	COG0237	dephospho-CoA kinase activity
HVY72_RS19185	COG0494	nUDIX hydrolase
HVY72_RS19205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVY72_RS19210	COG0849	cell division
HVY72_RS19220	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY72_RS19235	COG0772	Belongs to the SEDS family
HVY72_RS19240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HVY72_RS19250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVY72_RS19255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY72_RS19260	COG0768	penicillin binding
HVY72_RS19290	COG0028	Belongs to the TPP enzyme family
HVY72_RS19325	COG1609	Transcriptional regulator
HVY72_RS19335	COG1028	Short-chain dehydrogenase reductase Sdr
HVY72_RS19340	COG2814	Major facilitator Superfamily
HVY72_RS19360	COG1178	ABC-type Fe3 transport system permease component
HVY72_RS19370	COG0586	Pfam SNARE associated Golgi protein
HVY72_RS19390	COG0235	Class ii aldolase
HVY72_RS19395	COG0417	DNA replication proofreading
HVY72_RS19405	COG0564	pseudouridine synthase activity
HVY72_RS19420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY72_RS19465	COG2271	Major facilitator Superfamily
HVY72_RS19475	COG0644	oxidoreductase
HVY72_RS19525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVY72_RS19530	COG0505	Belongs to the CarA family
HVY72_RS19540	COG1609	Transcriptional regulator
HVY72_RS19555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS19555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS19560	COG3715	PTS system
HVY72_RS19565	COG3716	PTS system mannose fructose sorbose family IID component
HVY72_RS19575	COG2140	Oxalate decarboxylase
HVY72_RS19590	COG1047	Peptidyl-prolyl cis-trans
HVY72_RS19605	COG0196	riboflavin kinase activity
HVY72_RS19625	COG0583	DNA-binding transcription factor activity
HVY72_RS19640	COG0641	radical SAM
HVY72_RS19645	COG3119	arylsulfatase activity
HVY72_RS19660	COG0443	Heat shock 70 kDa protein
HVY72_RS19670	COG1584	GPR1 FUN34 yaaH family protein
HVY72_RS19680	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY72_RS19690	COG1115	amino acid carrier protein
HVY72_RS19700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVY72_RS19710	COG0460	homoserine dehydrogenase
HVY72_RS19710	COG0527	aspartate kinase activity
HVY72_RS19720	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVY72_RS19730	COG0745	RESPONSE REGULATOR receiver
HVY72_RS19735	COG4452	Inner membrane protein CreD
HVY72_RS19740	COG2205	protein histidine kinase activity
HVY72_RS19745	COG0745	RESPONSE REGULATOR receiver
HVY72_RS19750	COG3045	CreA protein
HVY72_RS19755	COG3708	Transcriptional regulator
HVY72_RS19755	COG2207	Transcriptional regulator
HVY72_RS19775	COG0741	lytic transglycosylase activity
HVY72_RS19780	COG0488	(ABC) transporter
HVY72_RS19795	COG0560	Phosphoserine phosphatase
HVY72_RS19800	COG3726	membrane protein affecting hemolysin expression
HVY72_RS19830	COG1328	CTP reductase activity
HVY72_RS19835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY72_RS19840	COG0084	hydrolase, TatD family'
HVY72_RS19845	COG4667	esterase of the alpha-beta hydrolase superfamily
HVY72_RS19850	COG5487	UPF0391 membrane protein
HVY72_RS19855	COG2823	Periplasmic or secreted lipoprotein
HVY72_RS19865	COG1011	Hydrolase
HVY72_RS19870	COG0456	acetyltransferase
HVY72_RS19875	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVY72_RS19905	COG3706	GGDEF domain
HVY72_RS19910	COG4114	ferric iron reductase
HVY72_RS19915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY72_RS19920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY72_RS19925	COG2197	response regulator
HVY72_RS19930	COG2197	response regulator
HVY72_RS19935	COG2966	Psort location CytoplasmicMembrane, score
HVY72_RS19950	COG1484	DNA-dependent DNA replication
HVY72_RS19970	COG1063	alcohol dehydrogenase
HVY72_RS19975	COG1802	Transcriptional regulator
HVY72_RS19980	COG2271	Major facilitator Superfamily
HVY72_RS19995	COG0840	transmembrane signaling receptor activity
HVY72_RS20000	COG1966	Carbon starvation protein
HVY72_RS20005	COG2879	small protein
HVY72_RS20010	COG0523	cobalamin synthesis protein
HVY72_RS20020	COG1566	PFAM secretion protein HlyD family protein
HVY72_RS20030	COG5457	Domain of unknown function (DUF1127)
HVY72_RS20035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY72_RS20040	COG5464	transposase or invertase
HVY72_RS20060	COG3477	response to acidic pH
HVY72_RS20065	COG0626	cystathionine gamma-synthase activity
HVY72_RS20070	COG1301	dicarboxylic acid transport
HVY72_RS20075	COG0583	DNA-binding transcription factor activity
HVY72_RS20080	COG2733	membrane
HVY72_RS20090	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVY72_RS20095	COG1924	4 iron, 4 sulfur cluster binding
HVY72_RS20105	COG0477	Major facilitator Superfamily
HVY72_RS20120	COG2186	Transcriptional regulator
HVY72_RS20125	COG0246	Mannitol dehydrogenase
HVY72_RS20135	COG2610	gluconate transmembrane transporter activity
HVY72_RS20140	COG1556	Lactate utilization protein
HVY72_RS20145	COG1139	Iron-sulfur cluster binding protein
HVY72_RS20150	COG0247	lactate metabolic process
HVY72_RS20155	COG1620	l-lactate permease
HVY72_RS20180	COG0531	amino acid
HVY72_RS20185	COG1012	belongs to the aldehyde dehydrogenase family
HVY72_RS20190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY72_RS20225	COG1715	Restriction endonuclease
HVY72_RS20240	COG2003	Belongs to the UPF0758 family
HVY72_RS20265	COG2378	regulation of single-species biofilm formation
HVY72_RS20270	COG3596	GTP binding
HVY72_RS20335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY72_RS20365	COG0582	viral genome integration into host DNA
HVY72_RS20375	COG1064	alcohol dehydrogenase
HVY72_RS20380	COG0433	COG0433 Predicted ATPase
HVY72_RS20385	COG0795	lipopolysaccharide-transporting ATPase activity
HVY72_RS20390	COG0795	lipopolysaccharide-transporting ATPase activity
HVY72_RS20400	COG2927	DNA polymerase III (CHI subunit)
HVY72_RS20405	COG0525	valine-tRNA ligase activity
HVY72_RS20440	COG2731	YhcH YjgK YiaL family protein
HVY72_RS20490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY72_RS20505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY72_RS20505	COG1263	PTS System
HVY72_RS20510	COG0366	Alpha amylase catalytic
HVY72_RS20525	COG2026	Addiction module toxin, RelE StbE family
HVY72_RS20530	COG3077	Addiction module antitoxin, RelB DinJ family
HVY72_RS20535	COG3711	transcriptional antiterminator
HVY72_RS20535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS20550	COG3964	amidohydrolase
HVY72_RS20585	COG0312	modulator of DNA gyrase
HVY72_RS20595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVY72_RS20605	COG0840	transmembrane signaling receptor activity
HVY72_RS20610	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY72_RS20615	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY72_RS20620	COG1129	ABC transporter
HVY72_RS20625	COG1879	ABC-type sugar transport system periplasmic component
HVY72_RS20635	COG3391	amine dehydrogenase activity
HVY72_RS20640	COG4771	TonB-dependent receptor
HVY72_RS20645	COG2105	PFAM AIG2 family protein
HVY72_RS20650	COG2911	Protein conserved in bacteria
HVY72_RS20655	COG0729	surface antigen
HVY72_RS20665	COG1253	flavin adenine dinucleotide binding
HVY72_RS20675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY72_RS20680	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVY72_RS20690	COG1733	regulation of RNA biosynthetic process
HVY72_RS20695	COG0702	epimerase
HVY72_RS20705	COG0697	spore germination
HVY72_RS20710	COG0840	transmembrane signaling receptor activity
HVY72_RS20720	COG1113	amino acid transport
HVY72_RS20725	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY72_RS20730	COG3061	Opacity-associated protein A
HVY72_RS20745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVY72_RS20760	COG0730	response to heat
HVY72_RS20815	COG1073	alpha beta
HVY72_RS20820	COG3650	response to hydrogen peroxide
HVY72_RS20830	COG1960	acyl-CoA dehydrogenase activity
HVY72_RS20835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY72_RS20840	COG0557	exoribonuclease II activity
HVY72_RS20855	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVY72_RS20860	COG0330	HflC and HflK could
HVY72_RS20865	COG0330	HflC and HflK could
HVY72_RS20870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVY72_RS20875	COG1923	regulation of RNA biosynthetic process
HVY72_RS20890	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY72_RS20895	COG0802	atpase or kinase
HVY72_RS20900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVY72_RS20900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVY72_RS20905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVY72_RS20940	COG3264	Mechanosensitive ion channel
HVY72_RS20940	COG1511	domain protein
HVY72_RS20955	COG1053	succinate dehydrogenase
HVY72_RS20960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY72_RS21015	COG1509	lysine 2,3-aminomutase activity
HVY72_RS21040	COG0531	amino acid
HVY72_RS21045	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVY72_RS21050	COG1027	Aspartate ammonia-lyase
HVY72_RS21055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY72_RS21070	COG1309	transcriptional regulator
HVY72_RS21085	COG0318	PFAM AMP-dependent synthetase and ligase
HVY72_RS21115	COG3290	protein histidine kinase activity
HVY72_RS21120	COG4565	transcriptional regulatory protein
HVY72_RS21125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY72_RS21130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS21130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY72_RS21135	COG3647	Membrane
HVY72_RS21145	COG2211	Major facilitator Superfamily
HVY72_RS21150	COG1486	melibiose metabolic process
HVY72_RS21155	COG2169	Transcriptional regulator
HVY72_RS21160	COG1982	Orn Lys Arg decarboxylase major
HVY72_RS21165	COG2207	Transcriptional regulator
HVY72_RS21170	COG0531	amino acid
HVY72_RS21210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVY72_RS21215	COG2824	Alkylphosphonate utilization operon protein PhnA
HVY72_RS21220	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVY72_RS21225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HVY72_RS21230	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVY72_RS21235	COG3639	organic phosphonate transmembrane transporter activity
HVY72_RS21240	COG2188	Transcriptional regulator
HVY72_RS21245	COG3624	Phosphonate C-P lyase system protein PhnG
HVY72_RS21250	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVY72_RS21255	COG3626	phosphonate metabolism
HVY72_RS21260	COG3627	carbon phosphorus lyase activity
HVY72_RS21265	COG4107	phosphonate C-P lyase system protein PhnK
HVY72_RS21270	COG4778	phosphonate C-P lyase system protein PhnL
HVY72_RS21275	COG3454	Phosphonate metabolism
HVY72_RS21285	COG0456	acetyltransferase
HVY72_RS21290	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVY72_RS21310	COG0784	Response regulator, receiver
HVY72_RS21310	COG4191	Histidine kinase
HVY72_RS21315	COG1129	ABC transporter
HVY72_RS21320	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY72_RS21390	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY72_RS21395	COG1301	dicarboxylic acid transport
HVY72_RS21400	COG4235	cytochrome complex assembly
HVY72_RS21405	COG3088	subunit of a heme lyase
HVY72_RS21410	COG1138	Cytochrome C-type biogenesis protein
HVY72_RS21415	COG3301	Polysulphide reductase, NrfD
HVY72_RS21420	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS21425	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVY72_RS21440	COG3162	membrane
HVY72_RS21450	COG1346	cytolysis
HVY72_RS21455	COG1380	Effector of murein hydrolase LrgA
HVY72_RS21460	COG0583	DNA-binding transcription factor activity
HVY72_RS21465	COG1943	Transposase
HVY72_RS21470	COG0025	NhaP-type Na H and K H
HVY72_RS21475	COG2252	PERMEase
HVY72_RS21480	COG0789	Transcriptional regulator
HVY72_RS21490	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY72_RS21500	COG0629	single-stranded DNA binding
HVY72_RS21505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVY72_RS21510	COG2315	Protein conserved in bacteria
HVY72_RS21515	COG3700	Belongs to the class B bacterial acid phosphatase family
HVY72_RS21520	COG1448	Aminotransferase
HVY72_RS21530	COG0305	Participates in initiation and elongation during chromosome replication
HVY72_RS21545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY72_RS21555	COG0735	belongs to the Fur family
HVY72_RS21560	COG3237	CsbD-like
HVY72_RS21565	COG0534	Mate efflux family protein
HVY72_RS21575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVY72_RS21610	COG2182	Extracellular solute-binding protein
HVY72_RS21620	COG3833	ABC-type maltose transport systems, permease component
HVY72_RS21625	COG0477	Major facilitator Superfamily
HVY72_RS21625	COG2814	Major facilitator Superfamily
HVY72_RS21630	COG3223	Belongs to the PsiE family
HVY72_RS21635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HVY72_RS21640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY72_RS21665	COG0527	aspartate kinase activity
HVY72_RS21670	COG3541	Predicted nucleotidyltransferase
HVY72_RS21680	COG4650	regulator
HVY72_RS21700	COG1187	pseudouridine synthase activity
HVY72_RS21740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVY72_RS21755	COG3657	addiction module killer protein
HVY72_RS21760	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY72_RS21775	COG1410	methionine synthase
HVY72_RS21775	COG0646	methionine synthase
HVY72_RS21785	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HVY72_RS21795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY72_RS21805	COG0456	acetyltransferase
HVY72_RS21830	COG0151	Belongs to the GarS family
HVY72_RS21840	COG4191	Histidine kinase
HVY72_RS21895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY72_RS21900	COG2104	thiamine diphosphate biosynthetic process
HVY72_RS21915	COG1278	Cold shock
HVY72_RS21925	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY72_RS21960	COG0250	Participates in transcription elongation, termination and antitermination
HVY72_RS22005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVY72_RS22065	COG0583	DNA-binding transcription factor activity
HVY72_RS22095	COG2194	sulfuric ester hydrolase activity
HVY72_RS22100	COG2207	Transcriptional regulator
HVY72_RS22105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS22110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY72_RS22115	COG1882	Formate acetyltransferase
HVY72_RS22120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS22125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY72_RS22130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS22130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY72_RS22130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY72_RS22140	COG0371	Dehydrogenase
HVY72_RS22150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVY72_RS22155	COG0583	DNA-binding transcription factor activity
HVY72_RS22165	COG0737	Belongs to the 5'-nucleotidase family
HVY72_RS22175	COG0460	homoserine dehydrogenase
HVY72_RS22175	COG0527	aspartate kinase activity
HVY72_RS22180	COG0626	cystathionine gamma-synthase activity
HVY72_RS22190	COG2211	Major facilitator Superfamily
HVY72_RS22205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVY72_RS22210	COG1609	Transcriptional regulator
HVY72_RS22215	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY72_RS22230	COG1575	Belongs to the MenA family. Type 1 subfamily
HVY72_RS22250	COG3074	FtsZ-dependent cytokinesis
HVY72_RS22255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVY72_RS22265	COG1494	fructose-1,6-bisphosphatase
HVY72_RS22275	COG3152	Membrane
HVY72_RS22290	COG0471	metal ion transport
HVY72_RS22320	COG3678	ATP-independent chaperone mediated protein folding
HVY72_RS22325	COG0745	RESPONSE REGULATOR receiver
HVY72_RS22330	COG2205	protein histidine kinase activity
HVY72_RS22335	COG2271	Major facilitator Superfamily
HVY72_RS22340	COG1082	Xylose isomerase domain protein TIM barrel
HVY72_RS22345	COG2188	Transcriptional regulator
HVY72_RS22350	COG2258	MOSC domain
HVY72_RS22355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY72_RS22400	COG1454	alcohol dehydrogenase
HVY72_RS22415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY72_RS22450	COG0437	4 iron, 4 sulfur cluster binding
HVY72_RS22455	COG2864	formate dehydrogenase
HVY72_RS22470	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HVY72_RS22480	COG3609	addiction module antidote protein, CC2985 family
HVY72_RS22490	COG0456	acetyltransferase
HVY72_RS22495	COG1490	D-aminoacyl-tRNA deacylase activity
HVY72_RS22505	COG1011	Hydrolase
HVY72_RS22510	COG1349	DNA-binding transcription factor activity
HVY72_RS22515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS22525	COG3684	Belongs to the aldolase LacD family
HVY72_RS22535	COG2017	converts alpha-aldose to the beta-anomer
HVY72_RS22540	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY72_RS22555	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVY72_RS22570	COG3852	Histidine kinase
HVY72_RS22585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY72_RS22605	COG0204	Acyl-transferase
HVY72_RS22620	COG3084	Protein conserved in bacteria
HVY72_RS22625	COG0746	molybdenum cofactor guanylyltransferase activity
HVY72_RS22630	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVY72_RS22670	COG1739	Uncharacterized protein family UPF0029
HVY72_RS22690	COG1609	Transcriptional regulator
HVY72_RS22695	COG1940	carbohydrate kinase activity
HVY72_RS22705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY72_RS22720	COG0805	protein transport
HVY72_RS22765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HVY72_RS22770	COG0583	DNA-binding transcription factor activity
HVY72_RS22775	COG0697	spore germination
HVY72_RS22780	COG0561	phosphatase activity
HVY72_RS22785	COG2267	carboxylic ester hydrolase activity
HVY72_RS22790	COG1280	lysine exporter protein (LysE YggA)
HVY72_RS22800	COG1280	lysine exporter protein (LysE YggA)
HVY72_RS22820	COG2962	Rard protein
HVY72_RS22835	COG1011	Hydrolase
HVY72_RS22880	COG2959	enzyme of heme biosynthesis
HVY72_RS22885	COG3071	HemY protein
HVY72_RS22930	COG2244	polysaccharide biosynthetic process
HVY72_RS22935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY72_RS22940	COG0456	acetyltransferase
HVY72_RS22945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY72_RS22950	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY72_RS22955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVY72_RS22970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVY72_RS22975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVY72_RS22985	COG3118	belongs to the thioredoxin family
HVY72_RS23010	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVY72_RS23020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY72_RS23025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY72_RS23045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY72_RS23055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY72_RS23060	COG3978	acetolactate synthase activity
HVY72_RS23080	COG3085	chromosome segregation
HVY72_RS23120	COG2186	Transcriptional regulator
HVY72_RS23125	COG0477	Major facilitator Superfamily
HVY72_RS23130	COG1609	Transcriptional regulator
HVY72_RS23135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY72_RS23140	COG1879	ABC-type sugar transport system periplasmic component
HVY72_RS23145	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY72_RS23180	COG1522	sequence-specific DNA binding
HVY72_RS23185	COG0716	FMN binding
HVY72_RS23200	COG3312	ion transport
HVY72_RS23225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HVY72_RS23235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HVY72_RS23240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HVY72_RS23255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY72_RS23260	COG0573	inorganic phosphate transmembrane transporter activity
HVY72_RS23265	COG0581	inorganic phosphate transmembrane transporter activity
HVY72_RS23275	COG0704	Plays a role in the regulation of phosphate uptake
HVY72_RS23280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY72_RS23285	COG2252	PERMEase
HVY72_RS23290	COG0431	NADPH-dependent FMN reductase
HVY72_RS23295	COG2091	lysine biosynthetic process via aminoadipic acid
HVY72_RS23310	COG3675	Pfam Lipase (class 3)
HVY72_RS23345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HVY72_RS23455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HVY72_RS23455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY72_RS23530	COG0697	spore germination
HVY72_RS23590	COG1192	Involved in chromosome partitioning
HVY72_RS23760	COG1475	DNA binding
HVY72_RS23780	COG2801	Transposase and inactivated derivatives
HVY72_RS23800	COG3547	Transposase (IS116 IS110 IS902 family)
HVY72_RS23810	COG3077	Addiction module antitoxin, RelB DinJ family
HVY72_RS23815	COG2026	Addiction module toxin, RelE StbE family
HVY72_RS23935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY72_RS23975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY72_RS24000	COG0697	spore germination
HVY72_RS24070	COG1192	Involved in chromosome partitioning
HVY72_RS24130	COG1475	DNA binding
HVY72_RS24320	COG2805	Type II/IV secretion system protein
HVY72_RS24365	COG0741	lytic transglycosylase activity
HVY72_RS24380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB