locus-tag	class	description
HV030_RS00010	COG0592	DNA-directed DNA polymerase activity
HV030_RS00025	COG0561	phosphatase activity
HV030_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV030_RS00040	COG5645	(Lipo)protein
HV030_RS00060	COG2149	membrane
HV030_RS00070	COG0641	radical SAM
HV030_RS00080	COG2610	gluconate transmembrane transporter activity
HV030_RS00085	COG0583	DNA-binding transcription factor activity
HV030_RS00095	COG2814	Major facilitator Superfamily
HV030_RS00115	COG0028	Belongs to the TPP enzyme family
HV030_RS00120	COG0440	acetolactate synthase activity
HV030_RS00125	COG2197	response regulator
HV030_RS00155	COG4580	involved in the transport of maltose and maltodextrins
HV030_RS00160	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV030_RS00165	COG2723	6-phospho-beta-galactosidase activity
HV030_RS00170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV030_RS00170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV030_RS00175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV030_RS00180	COG1609	Transcriptional regulator
HV030_RS00195	COG5464	transposase or invertase
HV030_RS00200	COG1464	Belongs to the NlpA lipoprotein family
HV030_RS00205	COG0697	spore germination
HV030_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS00230	COG0583	DNA-binding transcription factor activity
HV030_RS00240	COG3539	Fimbrial protein
HV030_RS00260	COG2197	response regulator
HV030_RS00325	COG2003	Belongs to the UPF0758 family
HV030_RS00355	COG2378	regulation of single-species biofilm formation
HV030_RS00365	COG3596	GTP binding
HV030_RS00410	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HV030_RS00430	COG0582	viral genome integration into host DNA
HV030_RS00440	COG1501	Belongs to the glycosyl hydrolase 31 family
HV030_RS00445	COG2982	Protein involved in outer membrane biogenesis
HV030_RS00450	COG2233	PERMEase
HV030_RS00455	COG0786	glutamate:sodium symporter activity
HV030_RS00460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV030_RS00465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV030_RS00470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV030_RS00490	COG2860	membrane
HV030_RS00495	COG1561	YicC-like family, N-terminal region
HV030_RS00505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HV030_RS00520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV030_RS00535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV030_RS00550	COG1519	Transferase
HV030_RS00555	COG0438	transferase activity, transferring glycosyl groups
HV030_RS00560	COG0515	serine threonine protein kinase
HV030_RS00565	COG1442	glycosyl transferase family 8
HV030_RS00580	COG0859	PFAM glycosyl transferase family 9
HV030_RS00585	COG1215	transferase activity, transferring glycosyl groups
HV030_RS00590	COG3307	-O-antigen
HV030_RS00600	COG0859	PFAM glycosyl transferase family 9
HV030_RS00610	COG0156	8-amino-7-oxononanoate synthase activity
HV030_RS00620	COG1216	Glycosyl transferase, family 2
HV030_RS00625	COG2861	carbohydrate metabolic process
HV030_RS00630	COG4942	peptidase
HV030_RS00640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV030_RS00645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV030_RS00660	COG1045	serine acetyltransferase
HV030_RS00665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV030_RS00670	COG2271	Major facilitator Superfamily
HV030_RS00680	COG2186	Transcriptional regulator
HV030_RS00700	COG3722	fumarate hydratase activity
HV030_RS00710	COG2213	PTS system mannitol-specific
HV030_RS00710	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS00720	COG1566	PFAM secretion protein HlyD family protein
HV030_RS00725	COG0625	glutathione transferase activity
HV030_RS00735	COG3276	selenocysteine insertion sequence binding
HV030_RS00740	COG1454	alcohol dehydrogenase
HV030_RS00745	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS00755	COG1566	PFAM secretion protein HlyD family protein
HV030_RS00760	COG0583	DNA-binding transcription factor activity
HV030_RS00765	COG3713	MltA-interacting MipA family protein
HV030_RS00775	COG2211	Major facilitator Superfamily
HV030_RS00785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV030_RS00790	COG3977	Valine--pyruvate aminotransferase
HV030_RS00795	COG0366	Alpha amylase catalytic
HV030_RS00800	COG2992	FlgJ-related protein
HV030_RS00805	COG1609	Transcriptional regulator
HV030_RS00805	COG2207	Transcriptional regulator
HV030_RS00815	COG1070	Carbohydrate kinase
HV030_RS00820	COG4682	membrane
HV030_RS00825	COG3274	enterobacterial common antigen metabolic process
HV030_RS00850	COG1278	Cold shock
HV030_RS00855	COG2944	sequence-specific DNA binding
HV030_RS00870	COG2271	Major facilitator Superfamily
HV030_RS00875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV030_RS00885	COG1609	Transcriptional regulator
HV030_RS00890	COG2885	chlorophyll binding
HV030_RS00895	COG0243	molybdopterin cofactor binding
HV030_RS00900	COG0456	acetyltransferase
HV030_RS00905	COG2818	Glycosylase
HV030_RS00910	COG5571	outer membrane autotransporter
HV030_RS00915	COG2223	nitrite transmembrane transporter activity
HV030_RS00940	COG0747	negative chemotaxis
HV030_RS00945	COG0601	transmembrane transport
HV030_RS00950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV030_RS00955	COG0444	Belongs to the ABC transporter superfamily
HV030_RS00960	COG4608	Belongs to the ABC transporter superfamily
HV030_RS00965	COG2204	response regulator
HV030_RS00970	COG0814	amino acid
HV030_RS00975	COG0626	cystathionine gamma-synthase activity
HV030_RS00980	COG2199	diguanylate cyclase activity
HV030_RS00980	COG2200	EAL domain
HV030_RS01005	COG1528	Iron-storage protein
HV030_RS01010	COG3039	Transposase
HV030_RS01030	COG0784	Response regulator, receiver
HV030_RS01030	COG2198	Histidine kinase
HV030_RS01030	COG2205	protein histidine kinase activity
HV030_RS01035	COG1879	ABC-type sugar transport system periplasmic component
HV030_RS01045	COG3039	Transposase
HV030_RS01055	COG3005	denitrification pathway
HV030_RS01075	COG3039	Transposase
HV030_RS01095	COG1858	cytochrome C peroxidase
HV030_RS01100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV030_RS01105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV030_RS01110	COG0339	signal peptide processing
HV030_RS01135	COG0589	response to stress
HV030_RS01145	COG0306	phosphate transporter
HV030_RS01150	COG2081	HI0933 family
HV030_RS01220	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS01250	COG0739	heme binding
HV030_RS01260	COG2132	Multicopper oxidase
HV030_RS01265	COG3667	copper resistance
HV030_RS01270	COG2372	response to copper ion
HV030_RS01275	COG1276	copper resistance
HV030_RS01280	COG0745	RESPONSE REGULATOR receiver
HV030_RS01285	COG2205	protein histidine kinase activity
HV030_RS01305	COG3479	Phenolic acid decarboxylase
HV030_RS01310	COG2091	lysine biosynthetic process via aminoadipic acid
HV030_RS01315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV030_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS01330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV030_RS01355	COG1216	Glycosyl transferase, family 2
HV030_RS01375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV030_RS01405	COG0628	permease
HV030_RS01420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV030_RS01435	COG3714	YhhN family
HV030_RS01445	COG3776	membrane
HV030_RS01450	COG0742	ribosomal rna small subunit methyltransferase
HV030_RS01455	COG0552	protein localization to endoplasmic reticulum
HV030_RS01460	COG2884	Cell division ATP-binding protein ftsE
HV030_RS01465	COG2177	Part of the ABC transporter FtsEX involved in
HV030_RS01485	COG0683	leucine binding
HV030_RS01495	COG4177	L-phenylalanine transmembrane transporter activity
HV030_RS01500	COG0411	ABC transporter
HV030_RS01525	COG1175	transmembrane transport
HV030_RS01540	COG0584	glycerophosphoryl diester phosphodiesterase
HV030_RS01550	COG0405	Gamma-glutamyltransferase
HV030_RS01560	COG1247	-acetyltransferase
HV030_RS01565	COG0673	inositol 2-dehydrogenase activity
HV030_RS01570	COG1741	Belongs to the pirin family
HV030_RS01575	COG1609	Transcriptional regulator
HV030_RS01580	COG3265	gluconokinase activity
HV030_RS01585	COG2610	gluconate transmembrane transporter activity
HV030_RS01600	COG2095	MarC family integral membrane protein
HV030_RS01605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV030_RS01630	COG0058	SHG alpha-glucan phosphorylase activity
HV030_RS01635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV030_RS01650	COG1349	DNA-binding transcription factor activity
HV030_RS01660	COG0058	SHG alpha-glucan phosphorylase activity
HV030_RS01665	COG1640	4-alpha-glucanotransferase
HV030_RS01670	COG2610	gluconate transmembrane transporter activity
HV030_RS01680	COG1040	competence protein
HV030_RS01700	COG1918	ferrous iron import across plasma membrane
HV030_RS01705	COG2183	response to ionizing radiation
HV030_RS01710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV030_RS01715	COG0745	RESPONSE REGULATOR receiver
HV030_RS01730	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV030_RS01740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV030_RS01745	COG1011	Hydrolase
HV030_RS01755	COG0494	nUDIX hydrolase
HV030_RS01760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV030_RS01765	COG4972	Pilus assembly protein
HV030_RS01800	COG3266	domain, Protein
HV030_RS01805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV030_RS01810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV030_RS01820	COG0180	Tryptophanyl-tRNA synthetase
HV030_RS01840	COG2146	nitrite reductase [NAD(P)H] activity
HV030_RS01845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV030_RS01870	COG0512	Glutamine amidotransferase of anthranilate synthase
HV030_RS01875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV030_RS01880	COG1289	transmembrane transporter activity
HV030_RS01890	COG1765	OsmC-like protein
HV030_RS01895	COG3954	Phosphoribulokinase
HV030_RS01905	COG0429	hydrolase of the alpha beta-hydrolase fold
HV030_RS01915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HV030_RS01950	COG0679	Auxin Efflux Carrier
HV030_RS01960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV030_RS01970	COG0488	(ABC) transporter
HV030_RS01985	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV030_RS01990	COG1047	Peptidyl-prolyl cis-trans
HV030_RS02000	COG0545	Peptidyl-prolyl cis-trans isomerase
HV030_RS02005	COG2964	Protein conserved in bacteria
HV030_RS02035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV030_RS02040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HV030_RS02060	COG0051	transcription antitermination factor activity, RNA binding
HV030_RS02070	COG0088	Forms part of the polypeptide exit tunnel
HV030_RS02085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV030_RS02160	COG0200	Binds to the 23S rRNA
HV030_RS02165	COG0201	protein transport
HV030_RS02180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV030_RS02195	COG0203	ribosomal protein L17
HV030_RS02205	COG0789	Transcriptional regulator
HV030_RS02210	COG3036	rescue of stalled ribosome
HV030_RS02240	COG0758	DNA mediated transformation
HV030_RS02250	COG0551	DNA topoisomerase type I activity
HV030_RS02270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV030_RS02310	COG1126	abc transporter atp-binding protein
HV030_RS02315	COG0765	amino acid transport
HV030_RS02320	COG4597	amino acid ABC transporter
HV030_RS02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV030_RS02340	COG3039	Transposase
HV030_RS02350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS02355	COG1309	transcriptional regulator
HV030_RS02365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV030_RS02395	COG4145	pantothenate transmembrane transporter activity
HV030_RS02400	COG3924	membrane
HV030_RS02405	COG0439	Biotin carboxylase
HV030_RS02410	COG0511	ligase activity, forming carbon-carbon bonds
HV030_RS02425	COG0604	alcohol dehydrogenase
HV030_RS02430	COG2199	diguanylate cyclase activity
HV030_RS02430	COG2200	EAL domain
HV030_RS02440	COG1077	Cell shape determining protein MreB Mrl
HV030_RS02445	COG1792	Involved in formation and maintenance of cell shape
HV030_RS02450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV030_RS02460	COG1530	ribonuclease E activity
HV030_RS02465	COG3164	Protein of unknown function
HV030_RS02470	COG0312	modulator of DNA gyrase
HV030_RS02475	COG0583	DNA-binding transcription factor activity
HV030_RS02495	COG2732	(Barnase) inhibitor
HV030_RS02515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV030_RS02520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV030_RS02525	COG3105	Protein conserved in bacteria
HV030_RS02530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV030_RS02540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HV030_RS02545	COG0625	glutathione transferase activity
HV030_RS02550	COG2969	positive regulation of protein catabolic process
HV030_RS02555	COG3069	C4-dicarboxylate transmembrane transporter activity
HV030_RS02560	COG2186	Transcriptional regulator
HV030_RS02580	COG2731	YhcH YjgK YiaL family protein
HV030_RS02585	COG0402	S-adenosylhomocysteine deaminase activity
HV030_RS02590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV030_RS02600	COG4804	nuclease activity
HV030_RS02605	COG0493	'glutamate synthase
HV030_RS02610	COG0067	glutamate synthase
HV030_RS02610	COG0069	glutamate synthase activity
HV030_RS02610	COG0070	glutamate synthase
HV030_RS02615	COG1242	4 iron, 4 sulfur cluster binding
HV030_RS02620	COG5002	protein histidine kinase activity
HV030_RS02620	COG2198	Histidine kinase
HV030_RS02620	COG0784	Response regulator, receiver
HV030_RS02625	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV030_RS02635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS02650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV030_RS02660	COG1137	ATPase activity
HV030_RS02665	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV030_RS02670	COG3117	lipopolysaccharide transmembrane transporter activity
HV030_RS02675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV030_RS02685	COG0530	calcium, potassium:sodium antiporter activity
HV030_RS02690	COG1127	ABC transporter
HV030_RS02695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV030_RS02700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV030_RS02705	COG2854	intermembrane phospholipid transfer
HV030_RS02710	COG3113	response to antibiotic
HV030_RS02715	COG5007	Belongs to the BolA IbaG family
HV030_RS02740	COG3423	Transcriptional regulator
HV030_RS02745	COG0142	geranyltranstransferase activity
HV030_RS02750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV030_RS02755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV030_RS02760	COG0697	spore germination
HV030_RS02765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HV030_RS02770	COG2027	D-alanyl-D-alanine carboxypeptidase
HV030_RS02780	COG1534	Rna-binding protein
HV030_RS02790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV030_RS02795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV030_RS02805	COG3069	C4-dicarboxylate transmembrane transporter activity
HV030_RS02810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV030_RS02815	COG0583	DNA-binding transcription factor activity
HV030_RS02820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV030_RS02845	COG0195	Participates in both transcription termination and antitermination
HV030_RS02850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV030_RS02855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV030_RS02885	COG0513	Belongs to the DEAD box helicase family
HV030_RS02890	COG0814	amino acid
HV030_RS02895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV030_RS02900	COG0826	peptidase U32
HV030_RS02905	COG0826	peptidase U32
HV030_RS02910	COG3154	lipid carrier protein
HV030_RS02915	COG3153	acetyltransferase
HV030_RS02930	COG0702	epimerase
HV030_RS02935	COG2823	Periplasmic or secreted lipoprotein
HV030_RS02955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV030_RS02965	COG3039	Transposase
HV030_RS02975	COG2721	sulfolactate sulfo-lyase activity
HV030_RS02990	COG2084	Dehydrogenase
HV030_RS02995	COG1929	Belongs to the glycerate kinase type-1 family
HV030_RS03005	COG0583	DNA-binding transcription factor activity
HV030_RS03035	COG1882	Formate acetyltransferase
HV030_RS03040	COG0251	oxidation-reduction process
HV030_RS03045	COG1760	l-serine dehydratase
HV030_RS03050	COG0814	amino acid
HV030_RS03065	COG1741	Belongs to the pirin family
HV030_RS03070	COG0583	DNA-binding transcription factor activity
HV030_RS03075	COG3152	Membrane
HV030_RS03080	COG0435	Glutathione S-transferase
HV030_RS03085	COG2259	Doxx family
HV030_RS03095	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV030_RS03100	COG4575	ribosome binding
HV030_RS03105	COG1422	Protein of unknown function (DUF1090)
HV030_RS03115	COG0586	Pfam SNARE associated Golgi protein
HV030_RS03120	COG2186	Transcriptional regulator
HV030_RS03125	COG2271	Major facilitator Superfamily
HV030_RS03135	COG2721	sulfolactate sulfo-lyase activity
HV030_RS03155	COG0673	inositol 2-dehydrogenase activity
HV030_RS03160	COG1451	nucleotide metabolic process
HV030_RS03170	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV030_RS03170	COG1902	pentaerythritol trinitrate reductase activity
HV030_RS03175	COG3408	Glycogen debranching enzyme
HV030_RS03175	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HV030_RS03185	COG0531	amino acid
HV030_RS03195	COG2731	YhcH YjgK YiaL family protein
HV030_RS03200	COG3250	beta-galactosidase activity
HV030_RS03205	COG1609	Transcriptional regulator
HV030_RS03210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV030_RS03220	COG0840	transmembrane signaling receptor activity
HV030_RS03225	COG1695	Transcriptional regulator
HV030_RS03230	COG2375	cellular response to nickel ion
HV030_RS03240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV030_RS03305	COG0583	DNA-binding transcription factor activity
HV030_RS03330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV030_RS03360	COG4983	Phage plasmid primase, P4 family domain protein
HV030_RS03385	COG3596	GTP binding
HV030_RS03415	COG3596	GTP binding
HV030_RS03425	COG2378	regulation of single-species biofilm formation
HV030_RS03430	COG3468	outer membrane autotransporter barrel domain protein
HV030_RS03440	COG2003	Belongs to the UPF0758 family
HV030_RS03475	COG0358	DNA primase activity
HV030_RS03480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV030_RS03485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV030_RS03490	COG0471	metal ion transport
HV030_RS03495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV030_RS03515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV030_RS03530	COG4991	sh3 domain protein
HV030_RS03535	COG3025	triphosphatase activity
HV030_RS03550	COG2268	Band 7 protein
HV030_RS03580	COG3384	dioxygenase
HV030_RS03585	COG0754	glutathionylspermidine amidase activity
HV030_RS03595	COG1538	Outer membrane efflux protein
HV030_RS03600	COG0494	nUDIX hydrolase
HV030_RS03605	COG3151	Protein conserved in bacteria
HV030_RS03610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV030_RS03615	COG3150	esterase
HV030_RS03620	COG0187	DNA topoisomerase II activity
HV030_RS03635	COG2211	Major facilitator Superfamily
HV030_RS03640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV030_RS03645	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV030_RS03650	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV030_RS03665	COG3111	PFAM Bacterial OB fold (BOF) protein
HV030_RS03685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV030_RS03690	COG1032	radical SAM domain protein
HV030_RS03695	COG0471	metal ion transport
HV030_RS03700	COG0656	L-ascorbic acid biosynthetic process
HV030_RS03705	COG1979	alcohol dehydrogenase
HV030_RS03710	COG2207	Transcriptional regulator
HV030_RS03715	COG0586	Pfam SNARE associated Golgi protein
HV030_RS03720	COG0626	cystathionine gamma-synthase activity
HV030_RS03730	COG0848	biopolymer transport protein
HV030_RS03755	COG0667	Aldo Keto reductase
HV030_RS03760	COG0840	transmembrane signaling receptor activity
HV030_RS03770	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV030_RS03775	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS03780	COG5557	Pfam Polysulphide reductase, NrfD
HV030_RS03785	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV030_RS03790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV030_RS03795	COG1773	rubredoxin
HV030_RS03805	COG0298	carbon dioxide binding
HV030_RS03810	COG0625	glutathione transferase activity
HV030_RS03815	COG0243	molybdopterin cofactor binding
HV030_RS03820	COG0754	glutathionylspermidine amidase activity
HV030_RS03870	COG2003	Belongs to the UPF0758 family
HV030_RS03895	COG4983	Phage plasmid primase, P4 family domain protein
HV030_RS03905	COG3311	Transcriptional regulator
HV030_RS03960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS03965	COG1129	ABC transporter
HV030_RS03965	COG0842	Transport permease protein
HV030_RS03970	COG0842	Transport permease protein
HV030_RS04020	COG0582	viral genome integration into host DNA
HV030_RS04055	COG2003	Belongs to the UPF0758 family
HV030_RS04120	COG3547	Transposase (IS116 IS110 IS902 family)
HV030_RS04195	COG1216	Glycosyl transferase, family 2
HV030_RS04240	COG0582	viral genome integration into host DNA
HV030_RS04255	COG0463	Glycosyl transferase, family 2
HV030_RS04290	COG2378	regulation of single-species biofilm formation
HV030_RS04295	COG4735	regulation of single-species biofilm formation
HV030_RS04330	COG4974	Belongs to the 'phage' integrase family
HV030_RS04355	COG1811	Na channel or pump
HV030_RS04360	COG1982	Orn Lys Arg decarboxylase major
HV030_RS04365	COG2211	Major facilitator Superfamily
HV030_RS04380	COG1194	a g-specific adenine glycosylase
HV030_RS04390	COG3171	Protein conserved in bacteria
HV030_RS04400	COG0252	asparaginase activity
HV030_RS04405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV030_RS04420	COG0762	integral membrane protein
HV030_RS04425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV030_RS04430	COG2805	Type II/IV secretion system protein
HV030_RS04445	COG0189	ligase activity
HV030_RS04450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV030_RS04455	COG2356	endonuclease I
HV030_RS04460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV030_RS04470	COG2814	Major facilitator Superfamily
HV030_RS04495	COG1166	arginine decarboxylase activity
HV030_RS04505	COG0501	Belongs to the peptidase M48B family
HV030_RS04510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV030_RS04515	COG1122	ATPase activity
HV030_RS04520	COG1122	ATPase activity
HV030_RS04550	COG0191	fructose-bisphosphate aldolase activity
HV030_RS04560	COG0668	transmembrane transport
HV030_RS04565	COG1279	arginine transmembrane transporter activity
HV030_RS04570	COG2968	Membrane
HV030_RS04575	COG0583	DNA-binding transcription factor activity
HV030_RS04580	COG0427	acetyl-CoA hydrolase
HV030_RS04585	COG1024	Enoyl-CoA hydratase
HV030_RS04590	COG1703	isobutyryl-CoA mutase activity
HV030_RS04595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV030_RS04595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV030_RS04610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV030_RS04615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV030_RS04635	COG0006	proline dipeptidase activity
HV030_RS04640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV030_RS04645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV030_RS04670	COG2723	6-phospho-beta-galactosidase activity
HV030_RS04675	COG1737	Transcriptional regulator
HV030_RS04685	COG1272	protein, Hemolysin III
HV030_RS04695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV030_RS04720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV030_RS04740	COG4942	peptidase
HV030_RS04765	COG3039	Transposase
HV030_RS04770	COG3121	Chaperone
HV030_RS04775	COG0583	DNA-binding transcription factor activity
HV030_RS04785	COG1609	Transcriptional regulator
HV030_RS04790	COG1609	Transcriptional regulator
HV030_RS04805	COG0667	Aldo Keto reductase
HV030_RS04815	COG0861	Integral membrane protein TerC family
HV030_RS04845	COG2165	general secretion pathway protein
HV030_RS04850	COG4795	General secretion pathway protein
HV030_RS04860	COG4967	type IV pilus modification protein PilV
HV030_RS04865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV030_RS04875	COG1074	ATP-dependent DNA helicase activity
HV030_RS04880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV030_RS04885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV030_RS04885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV030_RS04890	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV030_RS04910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV030_RS04915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV030_RS04920	COG2166	iron-sulfur cluster assembly
HV030_RS04925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV030_RS04935	COG0583	DNA-binding transcription factor activity
HV030_RS04940	COG2363	Small membrane protein
HV030_RS04950	COG1349	DNA-binding transcription factor activity
HV030_RS04960	COG1070	Carbohydrate kinase
HV030_RS04970	COG1129	ABC transporter
HV030_RS04975	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS04985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV030_RS04995	COG0235	Class ii aldolase
HV030_RS05000	COG1454	alcohol dehydrogenase
HV030_RS05010	COG1760	l-serine dehydratase
HV030_RS05015	COG0814	amino acid
HV030_RS05020	COG1611	Belongs to the LOG family
HV030_RS05035	COG3098	single-species biofilm formation
HV030_RS05040	COG0564	pseudouridine synthase activity
HV030_RS05045	COG0716	FMN binding
HV030_RS05060	COG2271	Major facilitator Superfamily
HV030_RS05065	COG4948	Mandelate Racemase Muconate Lactonizing
HV030_RS05070	COG4948	Mandelate Racemase Muconate Lactonizing
HV030_RS05075	COG1929	Belongs to the glycerate kinase type-1 family
HV030_RS05080	COG2205	protein histidine kinase activity
HV030_RS05080	COG4999	Histidine kinase
HV030_RS05080	COG3850	Histidine kinase
HV030_RS05080	COG3437	response regulator, receiver
HV030_RS05090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV030_RS05095	COG3956	TIGRFAM MazG family protein
HV030_RS05110	COG1737	Transcriptional regulator
HV030_RS05115	COG1263	PTS System
HV030_RS05115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS05115	COG2190	(PTS) system
HV030_RS05120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV030_RS05125	COG0602	queuosine metabolic process
HV030_RS05130	COG0720	synthase
HV030_RS05135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HV030_RS05150	COG2234	aminopeptidase activity
HV030_RS05185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HV030_RS05205	COG4942	peptidase
HV030_RS05205	COG1388	LysM domain
HV030_RS05220	COG0163	prenyltransferase activity
HV030_RS05225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV030_RS05245	COG3039	Transposase
HV030_RS05260	COG5001	Diguanylate cyclase
HV030_RS05265	COG3039	Transposase
HV030_RS05270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV030_RS05275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV030_RS05280	COG1121	(ABC) transporter
HV030_RS05300	COG0309	Hydrogenase expression formation protein (HypE)
HV030_RS05305	COG0409	Hydrogenase expression formation protein
HV030_RS05310	COG0298	carbon dioxide binding
HV030_RS05315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV030_RS05330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV030_RS05335	COG0651	ATP synthesis coupled electron transport
HV030_RS05340	COG0650	Formate hydrogenlyase subunit 4
HV030_RS05345	COG3261	NADH dehydrogenase
HV030_RS05345	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV030_RS05350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV030_RS05355	COG3260	NADH ubiquinone oxidoreductase 20
HV030_RS05365	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV030_RS05375	COG2723	6-phospho-beta-galactosidase activity
HV030_RS05380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS05380	COG1263	PTS System
HV030_RS05385	COG1609	Transcriptional regulator
HV030_RS05390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV030_RS05395	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV030_RS05415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV030_RS05415	COG0517	IMP dehydrogenase activity
HV030_RS05420	COG1349	DNA-binding transcription factor activity
HV030_RS05425	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS05440	COG3732	PTS system glucitol sorbitol-specific
HV030_RS05445	COG3730	PTS system glucitol sorbitol-specific
HV030_RS05450	COG2951	lytic endotransglycosylase activity
HV030_RS05455	COG1546	Belongs to the CinA family
HV030_RS05475	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV030_RS05505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV030_RS05510	COG1238	metal cluster binding
HV030_RS05525	COG2211	Major facilitator Superfamily
HV030_RS05540	COG2814	Major facilitator Superfamily
HV030_RS05545	COG1566	PFAM secretion protein HlyD family protein
HV030_RS05550	COG1846	Transcriptional regulator
HV030_RS05560	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV030_RS05565	COG2814	Major facilitator Superfamily
HV030_RS05575	COG4176	ABC-type proline glycine betaine transport system permease component
HV030_RS05585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV030_RS05590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV030_RS05605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV030_RS05635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV030_RS05640	COG0640	Transcriptional regulator
HV030_RS05645	COG0401	homolog of Blt101
HV030_RS05650	COG1802	Transcriptional regulator
HV030_RS05655	COG1113	amino acid transport
HV030_RS05660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV030_RS05665	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS05670	COG0579	oxidoreductase
HV030_RS05685	COG0583	DNA-binding transcription factor activity
HV030_RS05710	COG0642	Histidine kinase
HV030_RS05750	COG0297	glycogen (starch) synthase activity
HV030_RS05755	COG0438	transferase activity, transferring glycosyl groups
HV030_RS05755	COG0297	glycogen (starch) synthase activity
HV030_RS05785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV030_RS05790	COG1757	Na H antiporter
HV030_RS05795	COG2169	Transcriptional regulator
HV030_RS05815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV030_RS05820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV030_RS05825	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV030_RS05830	COG2271	Major facilitator Superfamily
HV030_RS05835	COG0477	Major facilitator Superfamily
HV030_RS05840	COG0363	glucosamine-6-phosphate deaminase activity
HV030_RS05845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV030_RS05850	COG1940	carbohydrate kinase activity
HV030_RS05850	COG1846	Transcriptional regulator
HV030_RS05875	COG3962	Belongs to the TPP enzyme family
HV030_RS05880	COG0673	inositol 2-dehydrogenase activity
HV030_RS05895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS05900	COG0673	inositol 2-dehydrogenase activity
HV030_RS05905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV030_RS05915	COG3718	enzyme involved in inositol metabolism
HV030_RS05935	COG2003	Belongs to the UPF0758 family
HV030_RS05960	COG2378	regulation of single-species biofilm formation
HV030_RS05970	COG3596	GTP binding
HV030_RS06045	COG0582	viral genome integration into host DNA
HV030_RS06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS06080	COG2867	negative regulation of translational initiation
HV030_RS06090	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV030_RS06095	COG0497	DNA recombination
HV030_RS06110	COG4536	flavin adenine dinucleotide binding
HV030_RS06115	COG4137	Cytochrome C assembly protein
HV030_RS06120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV030_RS06155	COG2885	chlorophyll binding
HV030_RS06160	COG2199	diguanylate cyclase activity
HV030_RS06175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV030_RS06180	COG0287	Prephenate dehydrogenase
HV030_RS06180	COG1605	Chorismate mutase
HV030_RS06185	COG0077	Prephenate dehydratase
HV030_RS06185	COG1605	Chorismate mutase
HV030_RS06195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV030_RS06200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV030_RS06215	COG0542	response to heat
HV030_RS06240	COG0477	Major facilitator Superfamily
HV030_RS06245	COG5544	Lipoprotein
HV030_RS06250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV030_RS06265	COG3118	belongs to the thioredoxin family
HV030_RS06270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV030_RS06285	COG0513	Belongs to the DEAD box helicase family
HV030_RS06295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV030_RS06305	COG1595	DNA-templated transcription, initiation
HV030_RS06315	COG3026	antisigma factor binding
HV030_RS06320	COG3086	response to oxidative stress
HV030_RS06330	COG0681	Belongs to the peptidase S26 family
HV030_RS06350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV030_RS06360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV030_RS06485	COG3179	chitinase
HV030_RS06515	COG4626	Terminase
HV030_RS06515	COG1802	Transcriptional regulator
HV030_RS06525	COG4695	Portal protein
HV030_RS06645	COG1737	Transcriptional regulator
HV030_RS06650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV030_RS06655	COG1263	PTS System
HV030_RS06655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS06660	COG0560	Phosphoserine phosphatase
HV030_RS06680	COG2205	protein histidine kinase activity
HV030_RS06685	COG3170	Tfp pilus assembly protein FimV
HV030_RS06690	COG2204	response regulator
HV030_RS06695	COG0347	Belongs to the P(II) protein family
HV030_RS06700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV030_RS06700	COG1017	nitric oxide dioxygenase activity
HV030_RS06730	COG4638	Rieske (2fe-2S)
HV030_RS06735	COG0583	DNA-binding transcription factor activity
HV030_RS06740	COG1940	carbohydrate kinase activity
HV030_RS06745	COG0457	Tetratricopeptide repeat
HV030_RS06750	COG2814	Major facilitator Superfamily
HV030_RS06750	COG0477	Major facilitator Superfamily
HV030_RS06760	COG2814	Major facilitator Superfamily
HV030_RS06765	COG3711	transcriptional antiterminator
HV030_RS06770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV030_RS06770	COG0517	IMP dehydrogenase activity
HV030_RS06775	COG1069	ribulokinase activity
HV030_RS06785	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS06790	COG1129	ABC transporter
HV030_RS06800	COG3683	transport system, periplasmic component
HV030_RS06805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV030_RS06825	COG1104	cysteine desulfurase activity
HV030_RS06830	COG0822	iron-sulfur transferase activity
HV030_RS06850	COG0633	Ferredoxin
HV030_RS06855	COG2975	iron-sulfur cluster assembly
HV030_RS06870	COG2897	thiosulfate sulfurtransferase activity
HV030_RS06875	COG2373	Large extracellular alpha-helical protein
HV030_RS06880	COG4953	penicillin-binding protein 1C
HV030_RS06885	COG0105	UTP biosynthetic process
HV030_RS06890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HV030_RS06910	COG2976	Protein conserved in bacteria
HV030_RS06925	COG3104	oligopeptide transport
HV030_RS06930	COG1645	bacterial-type flagellum-dependent swarming motility
HV030_RS06935	COG1388	LysM domain
HV030_RS06935	COG1470	cell adhesion involved in biofilm formation
HV030_RS06955	COG0517	IMP dehydrogenase activity
HV030_RS06955	COG0516	GMP reductase activity
HV030_RS07085	COG3179	chitinase
HV030_RS07100	COG0668	transmembrane transport
HV030_RS07110	COG2200	EAL domain
HV030_RS07125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV030_RS07140	COG2723	6-phospho-beta-galactosidase activity
HV030_RS07150	COG2233	PERMEase
HV030_RS07160	COG1393	Belongs to the ArsC family
HV030_RS07165	COG4783	chaperone-mediated protein folding
HV030_RS07170	COG0628	permease
HV030_RS07175	COG3366	ferrous iron transmembrane transporter activity
HV030_RS07180	COG0700	Nucleoside recognition
HV030_RS07185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV030_RS07190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV030_RS07195	COG2716	regulation of RNA biosynthetic process
HV030_RS07205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV030_RS07215	COG2321	neutral zinc metallopeptidase
HV030_RS07225	COG0400	carboxylic ester hydrolase activity
HV030_RS07240	COG1393	Belongs to the ArsC family
HV030_RS07250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV030_RS07255	COG3850	Histidine kinase
HV030_RS07260	COG0493	'glutamate synthase
HV030_RS07260	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV030_RS07270	COG5342	invasion associated locus B
HV030_RS07275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV030_RS07300	COG4812	Cobalamin adenosyltransferase
HV030_RS07305	COG0280	phosphate acetyltransferase
HV030_RS07340	COG4819	ethanolamine utilization protein
HV030_RS07360	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HV030_RS07365	COG2207	Transcriptional regulator
HV030_RS07375	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV030_RS07395	COG2837	iron assimilation
HV030_RS07405	COG4150	thiosulfate binding
HV030_RS07410	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV030_RS07415	COG4208	sulfate ABC transporter
HV030_RS07420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV030_RS07485	COG3530	Putative quorum-sensing-regulated virulence factor
HV030_RS07490	COG0385	Bile acid
HV030_RS07495	COG0583	DNA-binding transcription factor activity
HV030_RS07500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV030_RS07505	COG2211	Major facilitator Superfamily
HV030_RS07510	COG0583	DNA-binding transcription factor activity
HV030_RS07540	COG3415	Transposase
HV030_RS07545	COG3415	Transposase
HV030_RS07560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV030_RS07575	COG0667	Aldo Keto reductase
HV030_RS07580	COG3961	Belongs to the TPP enzyme family
HV030_RS07600	COG3279	Response regulator of the LytR AlgR family
HV030_RS07605	COG3275	phosphorelay sensor kinase activity
HV030_RS07610	COG0436	Aminotransferase
HV030_RS07625	COG1560	Kdo2-lipid A biosynthetic process
HV030_RS07655	COG3122	Protein conserved in bacteria
HV030_RS07665	COG2116	formate transmembrane transporter activity
HV030_RS07675	COG2067	long-chain fatty acid transport protein
HV030_RS07680	COG3691	Protein conserved in bacteria
HV030_RS07695	COG2062	phosphohistidine phosphatase, SixA
HV030_RS07720	COG0730	response to heat
HV030_RS07725	COG3101	peptidyl-lysine hydroxylation
HV030_RS07740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV030_RS07760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV030_RS07770	COG0586	Pfam SNARE associated Golgi protein
HV030_RS07780	COG0285	dihydrofolate synthase activity
HV030_RS07785	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV030_RS07795	COG1286	toxin biosynthetic process
HV030_RS07800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV030_RS07810	COG2211	Major facilitator Superfamily
HV030_RS07815	COG1609	Transcriptional regulator
HV030_RS07820	COG0163	prenyltransferase activity
HV030_RS07830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV030_RS07845	COG4598	ABC transporter
HV030_RS07850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV030_RS07855	COG1090	epimerase
HV030_RS07860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV030_RS07865	COG0625	glutathione transferase activity
HV030_RS07870	COG0625	glutathione transferase activity
HV030_RS07875	COG0622	Phosphoesterase
HV030_RS07885	COG1288	antiporter activity
HV030_RS07910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV030_RS07915	COG0490	domain, Protein
HV030_RS07915	COG0471	metal ion transport
HV030_RS07925	COG0436	Aminotransferase
HV030_RS07930	COG3039	Transposase
HV030_RS07935	COG0583	DNA-binding transcription factor activity
HV030_RS07955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV030_RS07960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HV030_RS07980	COG0839	Belongs to the complex I subunit 6 family
HV030_RS07990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV030_RS07995	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV030_RS08005	COG0835	chemotaxis
HV030_RS08005	COG0784	Response regulator, receiver
HV030_RS08015	COG2153	protein acetylation
HV030_RS08020	COG4575	ribosome binding
HV030_RS08025	COG1169	isochorismate synthase
HV030_RS08105	COG0247	lactate metabolic process
HV030_RS08115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV030_RS08120	COG2271	Major facilitator Superfamily
HV030_RS08125	COG0584	glycerophosphoryl diester phosphodiesterase
HV030_RS08130	COG0583	DNA-binding transcription factor activity
HV030_RS08140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV030_RS08165	COG0183	Belongs to the thiolase family
HV030_RS08170	COG2031	fatty acid transporter
HV030_RS08175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV030_RS08180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV030_RS08185	COG2204	response regulator
HV030_RS08190	COG3852	Histidine kinase
HV030_RS08200	COG2197	response regulator
HV030_RS08205	COG2198	Histidine kinase
HV030_RS08205	COG0642	Histidine kinase
HV030_RS08210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV030_RS08220	COG2169	Transcriptional regulator
HV030_RS08220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV030_RS08225	COG3145	DNA-N1-methyladenine dioxygenase activity
HV030_RS08230	COG4615	Cyclic peptide transporter
HV030_RS08235	COG2239	Acts as a magnesium transporter
HV030_RS08240	COG0659	secondary active sulfate transmembrane transporter activity
HV030_RS08255	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV030_RS08255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV030_RS08260	COG3062	negative regulation of establishment of protein localization
HV030_RS08270	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS08275	COG0348	domain, Protein
HV030_RS08280	COG3043	anaerobic respiration
HV030_RS08285	COG3005	denitrification pathway
HV030_RS08290	COG4133	protoheme IX ABC transporter activity
HV030_RS08300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV030_RS08305	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV030_RS08315	COG1138	Cytochrome C-type biogenesis protein
HV030_RS08320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV030_RS08325	COG4235	cytochrome complex assembly
HV030_RS08325	COG3088	subunit of a heme lyase
HV030_RS08330	COG2197	response regulator
HV030_RS08370	COG1061	Type III restriction enzyme res subunit
HV030_RS08375	COG1187	pseudouridine synthase activity
HV030_RS08380	COG2814	Major facilitator Superfamily
HV030_RS08390	COG4172	Belongs to the ABC transporter superfamily
HV030_RS08395	COG4239	(ABC) transporter, permease
HV030_RS08400	COG4174	ABC transporter (Permease)
HV030_RS08405	COG4166	transmembrane transport
HV030_RS08410	COG2200	EAL domain
HV030_RS08415	COG0791	NLP P60 protein
HV030_RS08420	COG0671	phosphoesterase, PA-phosphatase related
HV030_RS08425	COG0523	cobalamin synthesis protein
HV030_RS08430	COG0246	Mannitol dehydrogenase
HV030_RS08435	COG1312	Catalyzes the dehydration of D-mannonate
HV030_RS08440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV030_RS08445	COG3005	denitrification pathway
HV030_RS08455	COG3381	protein complex oligomerization
HV030_RS08475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS08475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS08480	COG1105	Belongs to the carbohydrate kinase PfkB family
HV030_RS08485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV030_RS08485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV030_RS08485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV030_RS08495	COG2855	membrane
HV030_RS08500	COG0583	DNA-binding transcription factor activity
HV030_RS08505	COG0833	amino acid
HV030_RS08510	COG4771	TonB-dependent receptor
HV030_RS08525	COG2311	Membrane
HV030_RS08540	COG1129	ABC transporter
HV030_RS08565	COG2949	membrane
HV030_RS08575	COG1346	cytolysis
HV030_RS08585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV030_RS08595	COG2226	methyltransferase
HV030_RS08605	COG0586	Pfam SNARE associated Golgi protein
HV030_RS08615	COG1686	Belongs to the peptidase S11 family
HV030_RS08620	COG0277	FAD linked oxidase domain protein
HV030_RS08625	COG1472	Belongs to the glycosyl hydrolase 3 family
HV030_RS08630	COG1732	Glycine betaine
HV030_RS08635	COG1174	glycine betaine transport
HV030_RS08640	COG1125	glycine betaine transport
HV030_RS08645	COG1174	glycine betaine transport
HV030_RS08655	COG0789	Transcriptional regulator
HV030_RS08660	COG3275	phosphorelay sensor kinase activity
HV030_RS08670	COG4807	Protein conserved in bacteria
HV030_RS08690	COG3539	Fimbrial protein
HV030_RS08695	COG3121	Chaperone
HV030_RS08710	COG5455	response to cobalt ion
HV030_RS08745	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS08780	COG0351	phosphomethylpyrimidine kinase
HV030_RS08785	COG2188	Transcriptional regulator
HV030_RS08790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV030_RS08795	COG1397	ADP-ribosylglycohydrolase
HV030_RS08800	COG2211	Major facilitator Superfamily
HV030_RS08805	COG1830	Aldolase
HV030_RS08810	COG4948	Mandelate Racemase Muconate Lactonizing
HV030_RS08815	COG0747	negative chemotaxis
HV030_RS08830	COG0444	Belongs to the ABC transporter superfamily
HV030_RS08835	COG4608	Belongs to the ABC transporter superfamily
HV030_RS08845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV030_RS08850	COG4160	amino acid transport
HV030_RS08855	COG4215	(ABC) transporter
HV030_RS08860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV030_RS08865	COG1126	abc transporter atp-binding protein
HV030_RS08905	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV030_RS08910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV030_RS08915	COG0702	epimerase
HV030_RS08920	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV030_RS08925	COG0028	Belongs to the TPP enzyme family
HV030_RS08935	COG4529	Protein conserved in bacteria
HV030_RS08945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV030_RS08960	COG2814	Major facilitator Superfamily
HV030_RS08965	COG1335	isochorismatase
HV030_RS08970	COG0582	viral genome integration into host DNA
HV030_RS08990	COG3459	Glycosyltransferase 36 associated
HV030_RS09000	COG1278	Cold shock
HV030_RS09020	COG3157	Type VI secretion system effector, Hcp
HV030_RS09030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV030_RS09040	COG2431	L-lysine efflux transmembrane transporter activity
HV030_RS09050	COG3593	DNA synthesis involved in DNA repair
HV030_RS09055	COG2990	Protein conserved in bacteria
HV030_RS09060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS09070	COG1278	Cold shock
HV030_RS09080	COG0542	response to heat
HV030_RS09085	COG4974	Belongs to the 'phage' integrase family
HV030_RS09120	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV030_RS09140	COG4695	Portal protein
HV030_RS09280	COG0745	RESPONSE REGULATOR receiver
HV030_RS09285	COG2205	protein histidine kinase activity
HV030_RS09315	COG0443	Heat shock 70 kDa protein
HV030_RS09320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV030_RS09325	COG5002	protein histidine kinase activity
HV030_RS09325	COG5001	Diguanylate cyclase
HV030_RS09325	COG3447	MASE1 domain protein
HV030_RS09340	COG2982	Protein involved in outer membrane biogenesis
HV030_RS09345	COG1253	flavin adenine dinucleotide binding
HV030_RS09365	COG0463	Glycosyl transferase, family 2
HV030_RS09370	COG1045	serine acetyltransferase
HV030_RS09375	COG0438	transferase activity, transferring glycosyl groups
HV030_RS09385	COG1216	Glycosyl transferase, family 2
HV030_RS09390	COG0110	maltose O-acetyltransferase activity
HV030_RS09395	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV030_RS09400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV030_RS09405	COG1051	belongs to the nudix hydrolase family
HV030_RS09410	COG0297	glycogen (starch) synthase activity
HV030_RS09420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV030_RS09425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV030_RS09430	COG2244	polysaccharide biosynthetic process
HV030_RS09435	COG2327	Polysaccharide pyruvyl transferase
HV030_RS09465	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV030_RS09505	COG1215	transferase activity, transferring glycosyl groups
HV030_RS09525	COG0438	transferase activity, transferring glycosyl groups
HV030_RS09530	COG0438	transferase activity, transferring glycosyl groups
HV030_RS09600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV030_RS09615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV030_RS09620	COG0583	DNA-binding transcription factor activity
HV030_RS09630	COG0531	amino acid
HV030_RS09635	COG2925	Exonuclease
HV030_RS09665	COG1289	transmembrane transporter activity
HV030_RS09700	COG4656	Part of a membrane complex involved in electron transport
HV030_RS09710	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS09890	COG1376	ErfK ybiS ycfS ynhG family protein
HV030_RS09900	COG1178	ABC-type Fe3 transport system permease component
HV030_RS09905	COG1840	ABC-type Fe3 transport system, periplasmic component
HV030_RS09920	COG0583	DNA-binding transcription factor activity
HV030_RS09930	COG0534	Mate efflux family protein
HV030_RS09960	COG3141	response to X-ray
HV030_RS09970	COG2979	Protein of unknown function (DUF533)
HV030_RS09975	COG1770	oligopeptidase
HV030_RS09980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV030_RS09985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV030_RS09995	COG2372	response to copper ion
HV030_RS10000	COG1276	copper resistance
HV030_RS10010	COG0582	viral genome integration into host DNA
HV030_RS10035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV030_RS10095	COG1484	DNA-dependent DNA replication
HV030_RS10165	COG3772	lysozyme
HV030_RS10190	COG5484	DNA packaging
HV030_RS10190	COG3728	DNA packaging
HV030_RS10275	COG1196	nuclear chromosome segregation
HV030_RS10370	COG3008	intermembrane lipid transfer
HV030_RS10375	COG2995	paraquat-inducible protein a
HV030_RS10380	COG1956	GAF domain-containing protein
HV030_RS10400	COG2814	Major facilitator Superfamily
HV030_RS10405	COG1414	Transcriptional regulator
HV030_RS10440	COG0768	penicillin binding
HV030_RS10445	COG2226	methyltransferase
HV030_RS10460	COG3716	PTS system mannose fructose sorbose family IID component
HV030_RS10465	COG3715	PTS system
HV030_RS10470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS10470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS10475	COG1253	flavin adenine dinucleotide binding
HV030_RS10480	COG2200	EAL domain
HV030_RS10485	COG1760	l-serine dehydratase
HV030_RS10505	COG0251	oxidation-reduction process
HV030_RS10510	COG1199	ATP-dependent helicase activity
HV030_RS10515	COG1214	PFAM Peptidase M22, glycoprotease
HV030_RS10520	COG3065	identical protein binding
HV030_RS10525	COG0318	PFAM AMP-dependent synthetase and ligase
HV030_RS10530	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV030_RS10540	COG2894	cell division
HV030_RS10555	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV030_RS10585	COG2719	SpoVR family
HV030_RS10595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV030_RS10605	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV030_RS10630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV030_RS10630	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HV030_RS10630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS10635	COG1461	Dihydroxyacetone kinase
HV030_RS10640	COG2376	Dihydroxyacetone kinase
HV030_RS10645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV030_RS10680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HV030_RS10685	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV030_RS10690	COG0745	RESPONSE REGULATOR receiver
HV030_RS10695	COG5002	protein histidine kinase activity
HV030_RS10700	COG0583	DNA-binding transcription factor activity
HV030_RS10705	COG1902	pentaerythritol trinitrate reductase activity
HV030_RS10710	COG0217	transcriptional regulatory protein
HV030_RS10715	COG0012	GTP binding
HV030_RS10735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV030_RS10735	COG2857	Cytochrome c1
HV030_RS10750	COG1120	ATPase activity
HV030_RS10755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV030_RS10770	COG0659	secondary active sulfate transmembrane transporter activity
HV030_RS10800	COG2890	protein-(glutamine-N5) methyltransferase activity
HV030_RS10820	COG0387	Pfam Sodium calcium exchanger
HV030_RS10825	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV030_RS10835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV030_RS10840	COG3707	response regulator
HV030_RS10845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV030_RS10850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV030_RS10855	COG1116	anion transmembrane transporter activity
HV030_RS10860	COG2146	nitrite reductase [NAD(P)H] activity
HV030_RS10860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV030_RS10865	COG0243	molybdopterin cofactor binding
HV030_RS10870	COG4932	domain protein
HV030_RS10875	COG2197	response regulator
HV030_RS10880	COG3850	Histidine kinase
HV030_RS10885	COG2223	nitrite transmembrane transporter activity
HV030_RS10890	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV030_RS10895	COG1140	nitrate reductase beta subunit
HV030_RS10900	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV030_RS10905	COG2181	nitrate reductase activity
HV030_RS10930	COG0788	formyltetrahydrofolate deformylase activity
HV030_RS10940	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV030_RS10945	COG0745	RESPONSE REGULATOR receiver
HV030_RS10950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV030_RS10960	COG1435	thymidine kinase activity
HV030_RS10965	COG1454	alcohol dehydrogenase
HV030_RS10965	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS10970	COG2095	MarC family integral membrane protein
HV030_RS10990	COG0444	Belongs to the ABC transporter superfamily
HV030_RS11000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV030_RS11025	COG2350	Protein conserved in bacteria
HV030_RS11050	COG3047	cAMP biosynthetic process
HV030_RS11070	COG3706	GGDEF domain
HV030_RS11095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HV030_RS11105	COG0009	L-threonylcarbamoyladenylate synthase
HV030_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS11125	COG0616	signal peptide processing
HV030_RS11155	COG3039	Transposase
HV030_RS11160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV030_RS11170	COG0671	phosphoesterase, PA-phosphatase related
HV030_RS11175	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV030_RS11180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV030_RS11190	COG0023	Translation Initiation Factor
HV030_RS11200	COG1349	DNA-binding transcription factor activity
HV030_RS11210	COG5001	Diguanylate cyclase
HV030_RS11220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV030_RS11220	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV030_RS11225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV030_RS11245	COG4171	peptide transport system, permease
HV030_RS11260	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV030_RS11265	COG1842	Phage shock protein A
HV030_RS11275	COG1983	PspC domain protein
HV030_RS11285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV030_RS11290	COG3106	COG3106 Predicted ATPase
HV030_RS11305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV030_RS11310	COG4948	Mandelate Racemase Muconate Lactonizing
HV030_RS11315	COG2866	Carboxypeptidase
HV030_RS11320	COG4166	transmembrane transport
HV030_RS11340	COG1349	DNA-binding transcription factor activity
HV030_RS11345	COG0346	lactoylglutathione lyase activity
HV030_RS11350	COG0668	transmembrane transport
HV030_RS11355	COG3182	Iron-regulated membrane protein
HV030_RS11380	COG2840	Smr protein MutS2
HV030_RS11385	COG3706	GGDEF domain
HV030_RS11395	COG0840	transmembrane signaling receptor activity
HV030_RS11410	COG0513	Belongs to the DEAD box helicase family
HV030_RS11420	COG0582	viral genome integration into host DNA
HV030_RS11425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV030_RS11440	COG2135	peptidase activity
HV030_RS11455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV030_RS11460	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV030_RS11460	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV030_RS11460	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV030_RS11460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV030_RS11465	COG3042	response to heat
HV030_RS11470	COG3187	Heat shock protein
HV030_RS11475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV030_RS11480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV030_RS11495	COG2911	Protein conserved in bacteria
HV030_RS11505	COG3784	Protein of unknown function (DUF1318)
HV030_RS11510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV030_RS11515	COG4589	Belongs to the CDS family
HV030_RS11525	COG2267	carboxylic ester hydrolase activity
HV030_RS11530	COG2453	phosphatase
HV030_RS11530	COG0671	phosphoesterase, PA-phosphatase related
HV030_RS11550	COG1643	Atp-dependent helicase
HV030_RS11555	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV030_RS11560	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS11595	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS11615	COG3038	cytochrome b561
HV030_RS11620	COG0697	spore germination
HV030_RS11625	COG3264	Mechanosensitive ion channel
HV030_RS11625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV030_RS11665	COG0840	transmembrane signaling receptor activity
HV030_RS11670	COG0583	DNA-binding transcription factor activity
HV030_RS11675	COG1227	inorganic diphosphatase activity
HV030_RS11680	COG5383	Protein conserved in bacteria
HV030_RS11690	COG2841	Protein conserved in bacteria
HV030_RS11700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV030_RS11705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV030_RS11710	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV030_RS11715	COG0500	methyltransferase
HV030_RS11725	COG0697	spore germination
HV030_RS11735	COG3135	benzoate transporter
HV030_RS11740	COG1396	sequence-specific DNA binding
HV030_RS11745	COG0826	peptidase U32
HV030_RS11760	COG1294	oxidase, subunit
HV030_RS11765	COG1271	oxidase subunit
HV030_RS11770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV030_RS11775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV030_RS11780	COG3842	ATPase activity
HV030_RS11785	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV030_RS11790	COG1177	transmembrane transport
HV030_RS11805	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS11815	COG0583	DNA-binding transcription factor activity
HV030_RS11845	COG0529	Catalyzes the synthesis of activated sulfate
HV030_RS11845	COG2046	Belongs to the sulfate adenylyltransferase family
HV030_RS11850	COG0456	acetyltransferase
HV030_RS11855	COG1396	sequence-specific DNA binding
HV030_RS11915	COG0747	negative chemotaxis
HV030_RS11925	COG3238	Protein conserved in bacteria
HV030_RS11930	COG1247	-acetyltransferase
HV030_RS11940	COG2130	NADP-dependent
HV030_RS11960	COG0840	transmembrane signaling receptor activity
HV030_RS11965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV030_RS11970	COG1473	amidohydrolase
HV030_RS11975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV030_RS11980	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV030_RS11995	COG1126	abc transporter atp-binding protein
HV030_RS12000	COG2271	Major facilitator Superfamily
HV030_RS12010	COG1609	Transcriptional regulator
HV030_RS12020	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV030_RS12030	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV030_RS12035	COG0384	phenazine biosynthesis protein PhzF
HV030_RS12040	COG2181	nitrate reductase activity
HV030_RS12045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV030_RS12050	COG1140	nitrate reductase beta subunit
HV030_RS12055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV030_RS12095	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS12100	COG2864	formate dehydrogenase
HV030_RS12105	COG3093	addiction module antidote protein HigA
HV030_RS12115	COG0488	(ABC) transporter
HV030_RS12130	COG1764	response to oxidative stress
HV030_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS12140	COG2610	gluconate transmembrane transporter activity
HV030_RS12145	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV030_RS12155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV030_RS12160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV030_RS12165	COG0583	DNA-binding transcription factor activity
HV030_RS12170	COG4608	Belongs to the ABC transporter superfamily
HV030_RS12175	COG0444	Belongs to the ABC transporter superfamily
HV030_RS12180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV030_RS12185	COG0601	transmembrane transport
HV030_RS12190	COG0747	negative chemotaxis
HV030_RS12195	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV030_RS12210	COG0840	transmembrane signaling receptor activity
HV030_RS12215	COG1566	PFAM secretion protein HlyD family protein
HV030_RS12235	COG4628	conserved protein (DUF2132)
HV030_RS12260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV030_RS12265	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV030_RS12280	COG0702	epimerase
HV030_RS12295	COG1064	alcohol dehydrogenase
HV030_RS12330	COG5002	protein histidine kinase activity
HV030_RS12410	COG3781	membrane
HV030_RS12435	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS12440	COG0583	DNA-binding transcription factor activity
HV030_RS12455	COG1846	Transcriptional regulator
HV030_RS12460	COG4977	sequence-specific DNA binding
HV030_RS12470	COG0697	spore germination
HV030_RS12475	COG2814	Major facilitator Superfamily
HV030_RS12485	COG3706	GGDEF domain
HV030_RS12495	COG4221	oxidoreductase activity
HV030_RS12500	COG1802	Transcriptional regulator
HV030_RS12510	COG0246	Mannitol dehydrogenase
HV030_RS12520	COG1063	alcohol dehydrogenase
HV030_RS12525	COG4948	Mandelate Racemase Muconate Lactonizing
HV030_RS12540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV030_RS12555	COG0243	molybdopterin cofactor binding
HV030_RS12560	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS12565	COG3302	dmso reductase anchor subunit
HV030_RS12570	COG3381	protein complex oligomerization
HV030_RS12580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV030_RS12585	COG1940	carbohydrate kinase activity
HV030_RS12590	COG0583	DNA-binding transcription factor activity
HV030_RS12595	COG2814	Major facilitator Superfamily
HV030_RS12605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV030_RS12615	COG3591	Belongs to the peptidase S1B family
HV030_RS12630	COG0628	permease
HV030_RS12635	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV030_RS12640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV030_RS12650	COG0531	amino acid
HV030_RS12660	COG3136	membrane protein required for alginate biosynthesis
HV030_RS12665	COG0745	RESPONSE REGULATOR receiver
HV030_RS12675	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV030_RS12690	COG2205	protein histidine kinase activity
HV030_RS12705	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV030_RS12705	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV030_RS12710	COG1482	cell wall glycoprotein biosynthetic process
HV030_RS12715	COG5339	Protein conserved in bacteria
HV030_RS12720	COG1609	Transcriptional regulator
HV030_RS12725	COG1263	PTS System
HV030_RS12725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS12730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV030_RS12745	COG0673	inositol 2-dehydrogenase activity
HV030_RS12795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV030_RS12805	COG0625	glutathione transferase activity
HV030_RS12810	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV030_RS12825	COG3895	Periplasmic Protein
HV030_RS12850	COG1566	PFAM secretion protein HlyD family protein
HV030_RS12865	COG4989	oxidoreductase activity
HV030_RS12870	COG3313	Fe-S protein
HV030_RS12875	COG1309	transcriptional regulator
HV030_RS12880	COG1902	pentaerythritol trinitrate reductase activity
HV030_RS12885	COG0346	lactoylglutathione lyase activity
HV030_RS12895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV030_RS12900	COG0791	NLP P60 protein
HV030_RS12905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV030_RS12910	COG2814	Major facilitator Superfamily
HV030_RS12925	COG0583	DNA-binding transcription factor activity
HV030_RS12930	COG2814	Major facilitator Superfamily
HV030_RS12935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV030_RS12940	COG0307	riboflavin synthase, alpha
HV030_RS12950	COG0564	pseudouridine synthase activity
HV030_RS12990	COG1309	transcriptional regulator
HV030_RS13000	COG0628	permease
HV030_RS13005	COG3706	GGDEF domain
HV030_RS13055	COG1470	cell adhesion involved in biofilm formation
HV030_RS13055	COG1388	LysM domain
HV030_RS13060	COG0583	DNA-binding transcription factor activity
HV030_RS13085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV030_RS13095	COG2010	Cytochrome c
HV030_RS13100	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV030_RS13110	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS13125	COG1113	amino acid transport
HV030_RS13135	COG0129	dihydroxy-acid dehydratase activity
HV030_RS13140	COG2271	Major facilitator Superfamily
HV030_RS13145	COG0800	Aldolase
HV030_RS13150	COG3734	2-keto-3-deoxy-galactonokinase
HV030_RS13165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV030_RS13175	COG0765	amino acid transport
HV030_RS13180	COG0765	amino acid transport
HV030_RS13190	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV030_RS13195	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS13205	COG2414	aldehyde ferredoxin oxidoreductase
HV030_RS13210	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS13245	COG1464	Belongs to the NlpA lipoprotein family
HV030_RS13250	COG2011	ABC-type metal ion transport system permease component
HV030_RS13270	COG1376	ErfK ybiS ycfS ynhG family protein
HV030_RS13285	COG0719	Fe-S assembly protein
HV030_RS13290	COG0396	ATPase activity
HV030_RS13295	COG0719	Fe-S assembly protein
HV030_RS13300	COG0316	Belongs to the HesB IscA family
HV030_RS13320	COG2050	protein possibly involved in aromatic compounds catabolism
HV030_RS13325	COG0247	lactate metabolic process
HV030_RS13325	COG0277	FAD linked oxidase domain protein
HV030_RS13330	COG0628	permease
HV030_RS13340	COG1472	Belongs to the glycosyl hydrolase 3 family
HV030_RS13350	COG0738	Major facilitator superfamily
HV030_RS13355	COG2271	Major facilitator Superfamily
HV030_RS13370	COG4670	ketone body catabolic process
HV030_RS13375	COG1960	acyl-CoA dehydrogenase activity
HV030_RS13380	COG1917	Cupin 2, conserved barrel domain protein
HV030_RS13380	COG2207	Transcriptional regulator
HV030_RS13385	COG2086	electron transfer activity
HV030_RS13390	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV030_RS13395	COG0644	oxidoreductase
HV030_RS13400	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV030_RS13405	COG0318	PFAM AMP-dependent synthetase and ligase
HV030_RS13410	COG0574	Belongs to the PEP-utilizing enzyme family
HV030_RS13410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV030_RS13425	COG4256	Hemin uptake protein
HV030_RS13430	COG4771	TonB-dependent receptor
HV030_RS13435	COG3720	iron ion transport
HV030_RS13440	COG4558	Periplasmic binding protein
HV030_RS13445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV030_RS13465	COG0791	NLP P60 protein
HV030_RS13475	COG0386	Belongs to the glutathione peroxidase family
HV030_RS13495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HV030_RS13510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV030_RS13535	COG3137	Salt-induced outer membrane protein
HV030_RS13540	COG1105	Belongs to the carbohydrate kinase PfkB family
HV030_RS13545	COG3001	Fructosamine kinase
HV030_RS13555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV030_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS13565	COG1988	membrane-bound metal-dependent
HV030_RS13580	COG0753	catalase activity
HV030_RS13590	COG1486	melibiose metabolic process
HV030_RS13610	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV030_RS13615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV030_RS13620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV030_RS13625	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV030_RS13635	COG0322	excinuclease ABC activity
HV030_RS13645	COG3678	ATP-independent chaperone mediated protein folding
HV030_RS13675	COG0708	Exodeoxyribonuclease III
HV030_RS13680	COG0398	Pfam SNARE associated Golgi protein
HV030_RS13685	COG0398	Pfam SNARE associated Golgi protein
HV030_RS13690	COG4134	Bacterial extracellular solute-binding protein
HV030_RS13700	COG4136	ATPase activity
HV030_RS13705	COG2897	thiosulfate sulfurtransferase activity
HV030_RS13710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV030_RS13715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV030_RS13720	COG0494	nUDIX hydrolase
HV030_RS13735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV030_RS13740	COG0709	Synthesizes selenophosphate from selenide and ATP
HV030_RS13745	COG0778	Nitroreductase
HV030_RS13750	COG0616	signal peptide processing
HV030_RS13755	COG0252	asparaginase activity
HV030_RS13760	COG1335	isochorismatase
HV030_RS13770	COG3139	Protein of unknown function (DUF1315)
HV030_RS13795	COG3713	MltA-interacting MipA family protein
HV030_RS13800	COG2766	serine protein kinase
HV030_RS13810	COG0110	maltose O-acetyltransferase activity
HV030_RS13820	COG2226	methyltransferase
HV030_RS13825	COG2199	diguanylate cyclase activity
HV030_RS13830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV030_RS13840	COG2207	Transcriptional regulator
HV030_RS13845	COG2807	transmembrane transport
HV030_RS13850	COG0504	CTP synthase activity
HV030_RS13855	COG3189	MarR family transcriptional regulator
HV030_RS13860	COG3042	response to heat
HV030_RS13865	COG2203	Gaf domain
HV030_RS13865	COG2199	diguanylate cyclase activity
HV030_RS13880	COG2261	transglycosylase associated protein
HV030_RS13885	COG3383	formate dehydrogenase (NAD+) activity
HV030_RS13900	COG3615	Tellurite resistance protein tehB
HV030_RS13910	COG1335	isochorismatase
HV030_RS13915	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV030_RS13920	COG1124	(ABC) transporter
HV030_RS13930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV030_RS13935	COG0601	transmembrane transport
HV030_RS13940	COG0747	negative chemotaxis
HV030_RS14005	COG4220	transposase activity
HV030_RS14030	COG3772	lysozyme
HV030_RS14040	COG1278	Cold shock
HV030_RS14045	COG1278	Cold shock
HV030_RS14080	COG0582	viral genome integration into host DNA
HV030_RS14100	COG0538	isocitrate dehydrogenase activity
HV030_RS14105	COG1187	pseudouridine synthase activity
HV030_RS14130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV030_RS14145	COG2850	peptidyl-arginine hydroxylation
HV030_RS14190	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS14215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV030_RS14250	COG1177	transmembrane transport
HV030_RS14255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV030_RS14265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV030_RS14275	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV030_RS14280	COG1136	(ABC) transporter
HV030_RS14285	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV030_RS14290	COG4763	Acyl-transferase
HV030_RS14295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV030_RS14300	COG1376	ErfK ybiS ycfS ynhG family protein
HV030_RS14300	COG1388	LysM domain
HV030_RS14310	COG1309	transcriptional regulator
HV030_RS14315	COG3134	Outer membrane lipoprotein
HV030_RS14320	COG1252	NADH dehydrogenase
HV030_RS14345	COG5633	Lipoprotein
HV030_RS14350	COG0537	adenosine 5'-monophosphoramidase activity
HV030_RS14355	COG4773	Receptor
HV030_RS14365	COG3327	negative regulation of DNA-templated transcription, initiation
HV030_RS14370	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV030_RS14375	COG0183	Belongs to the thiolase family
HV030_RS14380	COG2050	protein possibly involved in aromatic compounds catabolism
HV030_RS14385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV030_RS14390	COG1024	Enoyl-CoA hydratase
HV030_RS14395	COG1024	Enoyl-CoA hydratase
HV030_RS14400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV030_RS14405	COG2151	metal-sulfur cluster biosynthetic enzyme
HV030_RS14410	COG3396	Phenylacetate-CoA oxygenase
HV030_RS14415	COG3460	Phenylacetate-CoA oxygenase
HV030_RS14420	COG3396	Phenylacetate-CoA oxygenase
HV030_RS14425	COG2030	dehydratase
HV030_RS14425	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS14430	COG0800	Aldolase
HV030_RS14435	COG0129	dihydroxy-acid dehydratase activity
HV030_RS14440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV030_RS14445	COG1737	Transcriptional regulator
HV030_RS14455	COG1560	Kdo2-lipid A biosynthetic process
HV030_RS14460	COG0739	heme binding
HV030_RS14465	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV030_RS14475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV030_RS14495	COG0217	transcriptional regulatory protein
HV030_RS14500	COG0494	nUDIX hydrolase
HV030_RS14510	COG1335	isochorismatase
HV030_RS14515	COG1801	Protein of unknown function DUF72
HV030_RS14520	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV030_RS14540	COG3102	Protein conserved in bacteria
HV030_RS14555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV030_RS14585	COG0745	RESPONSE REGULATOR receiver
HV030_RS14610	COG1301	dicarboxylic acid transport
HV030_RS14615	COG0835	chemotaxis
HV030_RS14660	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS14665	COG1129	ABC transporter
HV030_RS14670	COG1879	ABC-type sugar transport system periplasmic component
HV030_RS14680	COG1528	Iron-storage protein
HV030_RS14690	COG0477	Major facilitator Superfamily
HV030_RS14705	COG1528	Iron-storage protein
HV030_RS14715	COG0814	amino acid
HV030_RS14720	COG3318	Belongs to the UPF0149 family
HV030_RS14720	COG3012	SEC-C Motif Domain Protein
HV030_RS14725	COG2608	mercury ion transmembrane transporter activity
HV030_RS14735	COG1305	Transglutaminase-like
HV030_RS14905	COG3179	chitinase
HV030_RS14925	COG1403	HNH endonuclease
HV030_RS14940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV030_RS15065	COG2197	response regulator
HV030_RS15075	COG2197	response regulator
HV030_RS15090	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HV030_RS15130	COG0366	Alpha amylase catalytic
HV030_RS15145	COG0425	Belongs to the sulfur carrier protein TusA family
HV030_RS15175	COG2882	bacterial-type flagellum organization
HV030_RS15235	COG5475	Uncharacterized small protein (DUF2158)
HV030_RS15240	COG2354	Protein conserved in bacteria
HV030_RS15245	COG0697	spore germination
HV030_RS15250	COG3727	T/G mismatch-specific endonuclease activity
HV030_RS15255	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV030_RS15260	COG1418	mRNA catabolic process
HV030_RS15265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV030_RS15270	COG1278	Cold shock
HV030_RS15275	COG1278	Cold shock
HV030_RS15295	COG1278	Cold shock
HV030_RS15310	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV030_RS15315	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV030_RS15385	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS15410	COG1403	HNH endonuclease
HV030_RS15415	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HV030_RS15435	COG3272	Protein of unknown function (DUF1722)
HV030_RS15505	COG0583	DNA-binding transcription factor activity
HV030_RS15520	COG0477	Major facilitator Superfamily
HV030_RS15525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV030_RS15540	COG0084	hydrolase, TatD family'
HV030_RS15545	COG0470	DNA polymerase III
HV030_RS15555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV030_RS15560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV030_RS15565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV030_RS15575	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS15600	COG1399	metal-binding, possibly nucleic acid-binding protein
HV030_RS15610	COG0564	pseudouridine synthase activity
HV030_RS15620	COG1530	ribonuclease E activity
HV030_RS15625	COG0583	DNA-binding transcription factor activity
HV030_RS15630	COG2814	Major facilitator Superfamily
HV030_RS15660	COG4786	Flagellar basal body rod
HV030_RS15665	COG4787	bacterial-type flagellum-dependent cell motility
HV030_RS15680	COG1558	bacterial-type flagellum-dependent cell motility
HV030_RS15720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV030_RS15790	COG3039	Transposase
HV030_RS15835	COG3038	cytochrome b561
HV030_RS15850	COG1560	Kdo2-lipid A biosynthetic process
HV030_RS15865	COG5645	(Lipo)protein
HV030_RS15885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV030_RS15940	COG3381	protein complex oligomerization
HV030_RS15960	COG1702	phosphate starvation-inducible protein PhoH
HV030_RS15985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV030_RS15990	COG0506	proline dehydrogenase activity
HV030_RS15990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV030_RS15990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV030_RS15995	COG3755	Protein conserved in bacteria
HV030_RS16000	COG1309	transcriptional regulator
HV030_RS16005	COG3729	General stress protein
HV030_RS16025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV030_RS16030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV030_RS16030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV030_RS16035	COG4232	protein-disulfide reductase activity
HV030_RS16065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS16070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV030_RS16075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV030_RS16080	COG1757	Na H antiporter
HV030_RS16085	COG1609	Transcriptional regulator
HV030_RS16095	COG2814	Major facilitator Superfamily
HV030_RS16100	COG0386	Belongs to the glutathione peroxidase family
HV030_RS16120	COG0656	L-ascorbic acid biosynthetic process
HV030_RS16135	COG0670	Belongs to the BI1 family
HV030_RS16145	COG2920	part of a sulfur-relay system
HV030_RS16165	COG1832	CoA-binding protein
HV030_RS16180	COG0210	DNA helicase
HV030_RS16185	COG3304	Inner membrane component domain
HV030_RS16190	COG1289	transmembrane transporter activity
HV030_RS16195	COG3070	regulator of competence-specific genes
HV030_RS16215	COG1067	ATP-dependent peptidase activity
HV030_RS16225	COG3130	regulation of translation
HV030_RS16230	COG3009	Protein conserved in bacteria
HV030_RS16235	COG3008	intermembrane lipid transfer
HV030_RS16235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV030_RS16240	COG2995	paraquat-inducible protein a
HV030_RS16245	COG0488	(ABC) transporter
HV030_RS16255	COG3217	Mosc domain protein beta barrel domain protein
HV030_RS16255	COG0633	Ferredoxin
HV030_RS16270	COG0431	NADPH-dependent FMN reductase
HV030_RS16275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV030_RS16285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV030_RS16295	COG0308	aminopeptidase N
HV030_RS16315	COG1448	Aminotransferase
HV030_RS16320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV030_RS16325	COG3108	Peptidase M15
HV030_RS16330	COG2989	Protein conserved in bacteria
HV030_RS16340	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV030_RS16350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV030_RS16355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV030_RS16360	COG3173	Aminoglycoside phosphotransferase
HV030_RS16375	COG3214	Protein conserved in bacteria
HV030_RS16380	COG1663	tetraacyldisaccharide 4'-kinase activity
HV030_RS16390	COG2333	competence protein COMEC
HV030_RS16390	COG0658	competence protein
HV030_RS16395	COG0776	regulation of translation
HV030_RS16400	COG0539	negative regulation of cytoplasmic translation
HV030_RS16420	COG2323	membrane
HV030_RS16425	COG1944	ATP diphosphatase activity
HV030_RS16430	COG2116	formate transmembrane transporter activity
HV030_RS16435	COG1882	Formate acetyltransferase
HV030_RS16440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV030_RS16450	COG0531	amino acid
HV030_RS16460	COG3302	dmso reductase anchor subunit
HV030_RS16465	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS16470	COG0243	molybdopterin cofactor binding
HV030_RS16480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV030_RS16490	COG1674	ftsk spoiiie
HV030_RS16490	COG1178	ABC-type Fe3 transport system permease component
HV030_RS16495	COG1522	sequence-specific DNA binding
HV030_RS16500	COG0492	ferredoxin-NADP+ reductase activity
HV030_RS16505	COG4988	ABC transporter
HV030_RS16510	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV030_RS16525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV030_RS16530	COG0583	DNA-binding transcription factor activity
HV030_RS16540	COG1335	isochorismatase
HV030_RS16560	COG1177	transmembrane transport
HV030_RS16565	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV030_RS16570	COG3842	ATPase activity
HV030_RS16575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV030_RS16625	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS16645	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV030_RS16650	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV030_RS16740	COG4695	Portal protein
HV030_RS16810	COG3039	Transposase
HV030_RS16825	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV030_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS16835	COG3226	Transcriptional regulator
HV030_RS16840	COG0738	Major facilitator superfamily
HV030_RS16845	COG0561	phosphatase activity
HV030_RS16855	COG2814	Major facilitator Superfamily
HV030_RS16860	COG0671	phosphoesterase, PA-phosphatase related
HV030_RS16865	COG1349	DNA-binding transcription factor activity
HV030_RS16870	COG1686	Belongs to the peptidase S11 family
HV030_RS16875	COG0625	glutathione transferase activity
HV030_RS16880	COG2133	pyrroloquinoline quinone binding
HV030_RS16890	COG0583	DNA-binding transcription factor activity
HV030_RS16895	COG0058	SHG alpha-glucan phosphorylase activity
HV030_RS16925	COG1446	asparaginase
HV030_RS16930	COG0303	'Molybdopterin
HV030_RS16935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV030_RS16940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV030_RS16945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV030_RS16950	COG1882	Formate acetyltransferase
HV030_RS16955	COG0561	phosphatase activity
HV030_RS16975	COG0488	(ABC) transporter
HV030_RS16980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV030_RS17015	COG1376	ErfK ybiS ycfS ynhG family protein
HV030_RS17020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV030_RS17035	COG2194	sulfuric ester hydrolase activity
HV030_RS17040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV030_RS17055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV030_RS17060	COG0765	amino acid transport
HV030_RS17065	COG1126	abc transporter atp-binding protein
HV030_RS17070	COG0668	transmembrane transport
HV030_RS17095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV030_RS17105	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV030_RS17110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV030_RS17120	COG0513	Belongs to the DEAD box helicase family
HV030_RS17125	COG1309	transcriptional regulator
HV030_RS17135	COG1131	(ABC) transporter
HV030_RS17140	COG0842	Transport permease protein
HV030_RS17145	COG0842	Transport permease protein
HV030_RS17155	COG3568	Endonuclease Exonuclease Phosphatase
HV030_RS17160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV030_RS17165	COG0392	lysyltransferase activity
HV030_RS17170	COG0670	Belongs to the BI1 family
HV030_RS17175	COG0314	molybdopterin synthase activity
HV030_RS17180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV030_RS17190	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV030_RS17240	COG1881	PFAM PEBP family protein
HV030_RS17270	COG4677	pectinesterase activity
HV030_RS17280	COG3039	Transposase
HV030_RS17295	COG0561	phosphatase activity
HV030_RS17305	COG4149	molybdate abc transporter
HV030_RS17310	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV030_RS17320	COG3585	molybdate ion transport
HV030_RS17320	COG2005	Transcriptional regulator
HV030_RS17325	COG1119	ATPase activity
HV030_RS17330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV030_RS17335	COG1085	galactose-1-phosphate uridylyltransferase
HV030_RS17345	COG2017	converts alpha-aldose to the beta-anomer
HV030_RS17355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV030_RS17365	COG1230	cation diffusion facilitator family transporter
HV030_RS17370	COG3201	nicotinamide mononucleotide transporter
HV030_RS17410	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV030_RS17415	COG2885	chlorophyll binding
HV030_RS17425	COG3064	Membrane
HV030_RS17430	COG0848	biopolymer transport protein
HV030_RS17435	COG0811	peptide transport
HV030_RS17440	COG0824	Thioesterase
HV030_RS17445	COG3790	cyd operon protein YbgE
HV030_RS17450	COG4890	Cyd operon protein YbgT
HV030_RS17455	COG1294	oxidase, subunit
HV030_RS17460	COG1271	oxidase subunit
HV030_RS17465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV030_RS17475	COG4865	methylaspartate mutase activity
HV030_RS17480	COG3799	methylaspartate ammonia-lyase activity
HV030_RS17495	COG1301	dicarboxylic acid transport
HV030_RS17505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV030_RS17505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV030_RS17515	COG0583	DNA-binding transcription factor activity
HV030_RS17520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV030_RS17520	COG1648	precorrin-2 dehydrogenase activity
HV030_RS17530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV030_RS17540	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV030_RS17545	COG0567	Dehydrogenase, E1 component
HV030_RS17550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV030_RS17555	COG1053	succinate dehydrogenase
HV030_RS17560	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV030_RS17565	COG2009	succinate dehydrogenase
HV030_RS17575	COG3180	Ammonia monooxygenase
HV030_RS17610	COG1984	allophanate hydrolase subunit 2
HV030_RS17615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV030_RS17620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV030_RS17640	COG3272	Protein of unknown function (DUF1722)
HV030_RS17670	COG2205	protein histidine kinase activity
HV030_RS17675	COG0745	RESPONSE REGULATOR receiver
HV030_RS17680	COG0033	Phosphoglucomutase
HV030_RS17690	COG0596	Alpha beta hydrolase
HV030_RS17710	COG0735	belongs to the Fur family
HV030_RS17715	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HV030_RS17715	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV030_RS17730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS17735	COG3715	PTS system
HV030_RS17740	COG3716	PTS system mannose fructose sorbose family IID component
HV030_RS17760	COG1263	PTS System
HV030_RS17760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS17760	COG2190	(PTS) system
HV030_RS17770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV030_RS17775	COG1940	carbohydrate kinase activity
HV030_RS17775	COG1846	Transcriptional regulator
HV030_RS17780	COG0647	UMP catabolic process
HV030_RS17785	COG0367	asparagine synthase
HV030_RS17825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV030_RS17835	COG1702	phosphate starvation-inducible protein PhoH
HV030_RS17840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV030_RS17865	COG0765	amino acid transport
HV030_RS17870	COG0765	amino acid transport
HV030_RS17875	COG1126	abc transporter atp-binding protein
HV030_RS17885	COG2888	peptidyl-tyrosine sulfation
HV030_RS17900	COG1466	dna polymerase III delta subunit
HV030_RS17910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV030_RS17920	COG0799	negative regulation of ribosome biogenesis
HV030_RS17930	COG0768	penicillin binding
HV030_RS17935	COG0772	Belongs to the SEDS family
HV030_RS17940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV030_RS17945	COG1686	Belongs to the peptidase S11 family
HV030_RS17965	COG2801	Transposase and inactivated derivatives
HV030_RS17970	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS17980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HV030_RS17985	COG3077	Addiction module antitoxin, RelB DinJ family
HV030_RS17990	COG2026	Addiction module toxin, RelE StbE family
HV030_RS18005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV030_RS18025	COG3069	C4-dicarboxylate transmembrane transporter activity
HV030_RS18030	COG4565	transcriptional regulatory protein
HV030_RS18035	COG3290	protein histidine kinase activity
HV030_RS18040	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV030_RS18050	COG2301	Belongs to the HpcH HpaI aldolase family
HV030_RS18055	COG3051	citrate lyase alpha subunit
HV030_RS18070	COG0471	metal ion transport
HV030_RS18075	COG3719	Belongs to the RNase T2 family
HV030_RS18080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV030_RS18090	COG3634	alkyl hydroperoxide reductase activity
HV030_RS18100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV030_RS18105	COG0583	DNA-binding transcription factor activity
HV030_RS18110	COG3969	phosphoadenosine phosphosulfate
HV030_RS18115	COG1475	DNA binding
HV030_RS18120	COG0436	Aminotransferase
HV030_RS18125	COG0371	Dehydrogenase
HV030_RS18130	COG2879	small protein
HV030_RS18135	COG1966	Carbon starvation protein
HV030_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS18150	COG3433	isochorismatase activity
HV030_RS18150	COG1535	isochorismatase
HV030_RS18155	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV030_RS18160	COG1169	isochorismate synthase
HV030_RS18165	COG4592	Periplasmic binding protein
HV030_RS18175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV030_RS18180	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV030_RS18185	COG1120	ATPase activity
HV030_RS18190	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV030_RS18200	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV030_RS18200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV030_RS18205	COG3251	PFAM MbtH domain protein
HV030_RS18210	COG2382	esterase
HV030_RS18215	COG4771	TonB-dependent receptor
HV030_RS18220	COG2977	Belongs to the P-Pant transferase superfamily
HV030_RS18260	COG2315	Protein conserved in bacteria
HV030_RS18270	COG0668	transmembrane transport
HV030_RS18290	COG2211	Major facilitator Superfamily
HV030_RS18295	COG1113	amino acid transport
HV030_RS18315	COG3039	Transposase
HV030_RS18320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV030_RS18325	COG2207	Transcriptional regulator
HV030_RS18330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV030_RS18335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS18340	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS18345	COG1538	Outer membrane efflux protein
HV030_RS18350	COG0745	RESPONSE REGULATOR receiver
HV030_RS18355	COG5002	protein histidine kinase activity
HV030_RS18380	COG0321	lipoyl(octanoyl) transferase activity
HV030_RS18380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV030_RS18460	COG3039	Transposase
HV030_RS18470	COG2501	S4 domain
HV030_RS18475	COG1988	membrane-bound metal-dependent
HV030_RS18485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV030_RS18495	COG1388	LysM domain
HV030_RS18495	COG2373	Large extracellular alpha-helical protein
HV030_RS18495	COG4932	domain protein
HV030_RS18505	COG0745	RESPONSE REGULATOR receiver
HV030_RS18510	COG3039	Transposase
HV030_RS18515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV030_RS18520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV030_RS18530	COG2011	ABC-type metal ion transport system permease component
HV030_RS18540	COG1464	Belongs to the NlpA lipoprotein family
HV030_RS18550	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV030_RS18555	COG4181	ATPase activity
HV030_RS18560	COG2755	lipolytic protein G-D-S-L family
HV030_RS18565	COG0300	oxidoreductase activity
HV030_RS18570	COG3118	belongs to the thioredoxin family
HV030_RS18575	COG0390	transport system, permease component
HV030_RS18580	COG4619	ABC transporter
HV030_RS18585	COG0330	HflC and HflK could
HV030_RS18590	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV030_RS18610	COG2217	Heavy metal translocating P-type atpase
HV030_RS18615	COG3735	TraB family
HV030_RS18630	COG2223	nitrite transmembrane transporter activity
HV030_RS18635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV030_RS18635	COG4651	solute:proton antiporter activity
HV030_RS18640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV030_RS18665	COG1882	Formate acetyltransferase
HV030_RS18670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV030_RS18670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS18670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV030_RS18705	COG2832	Protein of unknown function (DUF454)
HV030_RS18710	COG3923	Primosomal replication protein n
HV030_RS18720	COG3264	Mechanosensitive ion channel
HV030_RS18720	COG1196	nuclear chromosome segregation
HV030_RS18725	COG1309	transcriptional regulator
HV030_RS18730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV030_RS18735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV030_RS18765	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV030_RS18770	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV030_RS18775	COG2364	Membrane
HV030_RS18780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV030_RS18850	COG3695	enzyme binding
HV030_RS18855	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV030_RS18860	COG1946	Acyl-CoA thioesterase
HV030_RS18865	COG0004	ammonium transporteR
HV030_RS18870	COG0347	Belongs to the P(II) protein family
HV030_RS18875	COG1132	(ABC) transporter
HV030_RS18880	COG1132	(ABC) transporter
HV030_RS18885	COG1522	sequence-specific DNA binding
HV030_RS18900	COG4533	DNA binding
HV030_RS18910	COG0824	Thioesterase
HV030_RS18915	COG1555	photosystem II stabilization
HV030_RS18920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV030_RS18925	COG0776	regulation of translation
HV030_RS18930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV030_RS18950	COG0271	Belongs to the BolA IbaG family
HV030_RS18955	COG3056	Lipoprotein
HV030_RS18960	COG2223	nitrite transmembrane transporter activity
HV030_RS18965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV030_RS18970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV030_RS18975	COG1845	cytochrome c oxidase, subunit III
HV030_RS18980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV030_RS18990	COG2814	Major facilitator Superfamily
HV030_RS19030	COG0142	geranyltranstransferase activity
HV030_RS19040	COG0667	Aldo Keto reductase
HV030_RS19045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV030_RS19050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV030_RS19065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV030_RS19065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV030_RS19075	COG4238	major outer membrane lipoprotein
HV030_RS19085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV030_RS19090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV030_RS19095	COG1862	Preprotein translocase
HV030_RS19105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV030_RS19115	COG0450	alkyl hydroperoxide reductase
HV030_RS19125	COG0366	Alpha amylase catalytic
HV030_RS19140	COG5002	protein histidine kinase activity
HV030_RS19150	COG0420	3'-5' exonuclease activity
HV030_RS19155	COG0419	ATPase involved in DNA repair
HV030_RS19160	COG2814	Major facilitator Superfamily
HV030_RS19165	COG1940	carbohydrate kinase activity
HV030_RS19175	COG3123	guanosine phosphorylase activity
HV030_RS19180	COG4126	flavin adenine dinucleotide binding
HV030_RS19200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV030_RS19205	COG3706	GGDEF domain
HV030_RS19215	COG1785	Belongs to the alkaline phosphatase family
HV030_RS19230	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV030_RS19250	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV030_RS19255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV030_RS19260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV030_RS19265	COG3468	outer membrane autotransporter barrel domain protein
HV030_RS19270	COG0113	porphobilinogen synthase activity
HV030_RS19275	COG2175	clavaminate synthase activity
HV030_RS19280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV030_RS19285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV030_RS19290	COG4521	taurine ABC transporter
HV030_RS19305	COG2271	Major facilitator Superfamily
HV030_RS19310	COG1840	ABC-type Fe3 transport system, periplasmic component
HV030_RS19320	COG3842	ATPase activity
HV030_RS19340	COG2040	homocysteine
HV030_RS19345	COG0833	amino acid
HV030_RS19350	COG2814	Major facilitator Superfamily
HV030_RS19385	COG1414	Transcriptional regulator
HV030_RS19395	COG3039	Transposase
HV030_RS19425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV030_RS19440	COG1609	Transcriptional regulator
HV030_RS19450	COG2223	nitrite transmembrane transporter activity
HV030_RS19460	COG2079	MmgE PrpD family protein
HV030_RS19465	COG0372	Belongs to the citrate synthase family
HV030_RS19475	COG3829	transcription factor binding
HV030_RS19485	COG1280	lysine exporter protein (LysE YggA)
HV030_RS19490	COG3706	GGDEF domain
HV030_RS19495	COG0348	domain, Protein
HV030_RS19515	COG0693	protein deglycase activity
HV030_RS19560	COG1136	(ABC) transporter
HV030_RS19570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HV030_RS19580	COG0531	amino acid
HV030_RS19585	COG0174	glutamine synthetase
HV030_RS19590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV030_RS19595	COG1396	sequence-specific DNA binding
HV030_RS19595	COG1917	Cupin 2, conserved barrel domain protein
HV030_RS19600	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS19605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV030_RS19670	COG3561	AntA/AntB antirepressor
HV030_RS19690	COG0582	viral genome integration into host DNA
HV030_RS19840	COG5410	chromosome segregation
HV030_RS19865	COG3646	Phage regulatory protein
HV030_RS20025	COG4712	double-strand break repair protein
HV030_RS20030	COG0629	single-stranded DNA binding
HV030_RS20080	COG0582	viral genome integration into host DNA
HV030_RS20085	COG0582	viral genome integration into host DNA
HV030_RS20145	COG3344	reverse transcriptase
HV030_RS20155	COG2826	transposase and inactivated derivatives, IS30 family
HV030_RS20200	COG3039	Transposase
HV030_RS20205	COG0583	DNA-binding transcription factor activity
HV030_RS20210	COG3596	GTP binding
HV030_RS20220	COG2378	regulation of single-species biofilm formation
HV030_RS20230	COG2378	regulation of single-species biofilm formation
HV030_RS20250	COG2003	Belongs to the UPF0758 family
HV030_RS20305	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV030_RS20330	COG0791	NLP P60 protein
HV030_RS20335	COG3034	peptidoglycan biosynthetic process
HV030_RS20340	COG0121	glutamine amidotransferase
HV030_RS20350	COG1960	acyl-CoA dehydrogenase activity
HV030_RS20355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV030_RS20370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV030_RS20380	COG2226	methyltransferase
HV030_RS20390	COG0741	lytic transglycosylase activity
HV030_RS20390	COG1388	LysM domain
HV030_RS20395	COG2226	methyltransferase
HV030_RS20405	COG2814	Major facilitator Superfamily
HV030_RS20410	COG0583	DNA-binding transcription factor activity
HV030_RS20445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV030_RS20455	COG2011	ABC-type metal ion transport system permease component
HV030_RS20460	COG1464	Belongs to the NlpA lipoprotein family
HV030_RS20470	COG1720	tRNA m6t6A37 methyltransferase activity
HV030_RS20480	COG3015	lipoprotein NlpE involved in copper resistance
HV030_RS20485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV030_RS20500	COG4568	rho-dependent transcription termination
HV030_RS20510	COG0346	lactoylglutathione lyase activity
HV030_RS20550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV030_RS20555	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV030_RS20570	COG0575	Belongs to the CDS family
HV030_RS20580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV030_RS20625	COG3835	regulator
HV030_RS20630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV030_RS20650	COG2860	membrane
HV030_RS20675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV030_RS20680	COG1120	ATPase activity
HV030_RS20685	COG4774	siderophore transport
HV030_RS20690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV030_RS20695	COG1643	Atp-dependent helicase
HV030_RS20700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV030_RS20720	COG0617	tRNA 3'-terminal CCA addition
HV030_RS20725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV030_RS20735	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HV030_RS20745	COG3539	Fimbrial protein
HV030_RS20750	COG3121	Chaperone
HV030_RS20755	COG3188	usher protein
HV030_RS20765	COG3539	Fimbrial protein
HV030_RS20775	COG3539	Fimbrial protein
HV030_RS20780	COG0726	polysaccharide deacetylase
HV030_RS20785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS20790	COG0842	Transport permease protein
HV030_RS20795	COG1131	(ABC) transporter
HV030_RS20800	COG0288	reversible hydration of carbon dioxide
HV030_RS20805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV030_RS20825	COG1609	Transcriptional regulator
HV030_RS20830	COG2814	Major facilitator Superfamily
HV030_RS20850	COG3064	Membrane
HV030_RS20860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV030_RS20865	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV030_RS20870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV030_RS20875	COG2186	Transcriptional regulator
HV030_RS20885	COG2211	Major facilitator Superfamily
HV030_RS20890	COG3940	Belongs to the glycosyl hydrolase 43 family
HV030_RS20895	COG3725	Membrane protein required for beta-lactamase induction
HV030_RS20910	COG4969	Belongs to the N-Me-Phe pilin family
HV030_RS20915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV030_RS20920	COG1459	type II secretion system
HV030_RS20930	COG0237	dephospho-CoA kinase activity
HV030_RS20945	COG0494	nUDIX hydrolase
HV030_RS20965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV030_RS20970	COG0849	cell division
HV030_RS20980	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV030_RS20995	COG0772	Belongs to the SEDS family
HV030_RS21010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV030_RS21015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV030_RS21020	COG0768	penicillin binding
HV030_RS21050	COG0028	Belongs to the TPP enzyme family
HV030_RS21070	COG0473	3-isopropylmalate dehydrogenase activity
HV030_RS21085	COG2814	Major facilitator Superfamily
HV030_RS21105	COG1178	ABC-type Fe3 transport system permease component
HV030_RS21115	COG0586	Pfam SNARE associated Golgi protein
HV030_RS21135	COG0235	Class ii aldolase
HV030_RS21145	COG0417	DNA replication proofreading
HV030_RS21155	COG0564	pseudouridine synthase activity
HV030_RS21165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV030_RS21170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV030_RS21215	COG2271	Major facilitator Superfamily
HV030_RS21225	COG0644	oxidoreductase
HV030_RS21285	COG0505	Belongs to the CarA family
HV030_RS21295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV030_RS21315	COG1047	Peptidyl-prolyl cis-trans
HV030_RS21330	COG0196	riboflavin kinase activity
HV030_RS21340	COG0583	DNA-binding transcription factor activity
HV030_RS21355	COG0443	Heat shock 70 kDa protein
HV030_RS21365	COG1584	GPR1 FUN34 yaaH family protein
HV030_RS21370	COG0477	Major facilitator Superfamily
HV030_RS21375	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV030_RS21385	COG1115	amino acid carrier protein
HV030_RS21395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV030_RS21405	COG0460	homoserine dehydrogenase
HV030_RS21405	COG0527	aspartate kinase activity
HV030_RS21415	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV030_RS21425	COG0745	RESPONSE REGULATOR receiver
HV030_RS21430	COG4452	Inner membrane protein CreD
HV030_RS21435	COG2205	protein histidine kinase activity
HV030_RS21440	COG0745	RESPONSE REGULATOR receiver
HV030_RS21445	COG3045	CreA protein
HV030_RS21450	COG2207	Transcriptional regulator
HV030_RS21450	COG3708	Transcriptional regulator
HV030_RS21470	COG0741	lytic transglycosylase activity
HV030_RS21475	COG0488	(ABC) transporter
HV030_RS21490	COG0560	Phosphoserine phosphatase
HV030_RS21495	COG3726	membrane protein affecting hemolysin expression
HV030_RS21525	COG1328	CTP reductase activity
HV030_RS21530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV030_RS21535	COG0084	hydrolase, TatD family'
HV030_RS21540	COG4667	esterase of the alpha-beta hydrolase superfamily
HV030_RS21545	COG5487	UPF0391 membrane protein
HV030_RS21550	COG2823	Periplasmic or secreted lipoprotein
HV030_RS21560	COG1011	Hydrolase
HV030_RS21565	COG0456	acetyltransferase
HV030_RS21570	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV030_RS21600	COG3706	GGDEF domain
HV030_RS21605	COG4114	ferric iron reductase
HV030_RS21610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV030_RS21615	COG2197	response regulator
HV030_RS21620	COG2197	response regulator
HV030_RS21625	COG2966	Psort location CytoplasmicMembrane, score
HV030_RS21640	COG1484	DNA-dependent DNA replication
HV030_RS21655	COG1063	alcohol dehydrogenase
HV030_RS21660	COG1802	Transcriptional regulator
HV030_RS21665	COG2271	Major facilitator Superfamily
HV030_RS21670	COG0840	transmembrane signaling receptor activity
HV030_RS21675	COG1966	Carbon starvation protein
HV030_RS21680	COG2879	small protein
HV030_RS21685	COG0523	cobalamin synthesis protein
HV030_RS21715	COG5457	Domain of unknown function (DUF1127)
HV030_RS21720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV030_RS21725	COG5464	transposase or invertase
HV030_RS21735	COG0626	cystathionine gamma-synthase activity
HV030_RS21740	COG1301	dicarboxylic acid transport
HV030_RS21750	COG2733	membrane
HV030_RS21760	COG0477	Major facilitator Superfamily
HV030_RS21780	COG1556	Lactate utilization protein
HV030_RS21785	COG1139	Iron-sulfur cluster binding protein
HV030_RS21790	COG0247	lactate metabolic process
HV030_RS21795	COG0277	FAD linked oxidase domain protein
HV030_RS21800	COG1620	l-lactate permease
HV030_RS21830	COG0531	amino acid
HV030_RS21835	COG1012	belongs to the aldehyde dehydrogenase family
HV030_RS21840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV030_RS21885	COG1064	alcohol dehydrogenase
HV030_RS21890	COG3265	gluconokinase activity
HV030_RS21895	COG1063	alcohol dehydrogenase
HV030_RS21900	COG1028	Short-chain dehydrogenase reductase Sdr
HV030_RS21905	COG2610	gluconate transmembrane transporter activity
HV030_RS21910	COG1609	Transcriptional regulator
HV030_RS21915	COG0433	COG0433 Predicted ATPase
HV030_RS21920	COG0795	lipopolysaccharide-transporting ATPase activity
HV030_RS21925	COG0795	lipopolysaccharide-transporting ATPase activity
HV030_RS21935	COG2927	DNA polymerase III (CHI subunit)
HV030_RS21940	COG0525	valine-tRNA ligase activity
HV030_RS21970	COG2731	YhcH YjgK YiaL family protein
HV030_RS22005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV030_RS22020	COG1263	PTS System
HV030_RS22020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV030_RS22025	COG0366	Alpha amylase catalytic
HV030_RS22040	COG2026	Addiction module toxin, RelE StbE family
HV030_RS22045	COG3077	Addiction module antitoxin, RelB DinJ family
HV030_RS22050	COG3711	transcriptional antiterminator
HV030_RS22050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV030_RS22065	COG3964	amidohydrolase
HV030_RS22100	COG0312	modulator of DNA gyrase
HV030_RS22120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV030_RS22135	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS22140	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS22145	COG1129	ABC transporter
HV030_RS22150	COG1879	ABC-type sugar transport system periplasmic component
HV030_RS22160	COG3391	amine dehydrogenase activity
HV030_RS22180	COG2105	PFAM AIG2 family protein
HV030_RS22185	COG2911	Protein conserved in bacteria
HV030_RS22190	COG0729	surface antigen
HV030_RS22200	COG1609	Transcriptional regulator
HV030_RS22205	COG0673	inositol 2-dehydrogenase activity
HV030_RS22210	COG0673	inositol 2-dehydrogenase activity
HV030_RS22225	COG2211	Major facilitator Superfamily
HV030_RS22235	COG1253	flavin adenine dinucleotide binding
HV030_RS22245	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV030_RS22250	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV030_RS22260	COG1733	regulation of RNA biosynthetic process
HV030_RS22265	COG0702	epimerase
HV030_RS22275	COG0697	spore germination
HV030_RS22280	COG0840	transmembrane signaling receptor activity
HV030_RS22290	COG1113	amino acid transport
HV030_RS22295	COG0545	Peptidyl-prolyl cis-trans isomerase
HV030_RS22300	COG3061	Opacity-associated protein A
HV030_RS22315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV030_RS22320	COG2965	DNA replication, synthesis of RNA primer
HV030_RS22330	COG0730	response to heat
HV030_RS22385	COG1073	alpha beta
HV030_RS22390	COG3650	response to hydrogen peroxide
HV030_RS22400	COG1960	acyl-CoA dehydrogenase activity
HV030_RS22405	COG0754	glutathionylspermidine amidase activity
HV030_RS22410	COG5463	Belongs to the UPF0441 family
HV030_RS22415	COG3766	membrane
HV030_RS22425	COG1842	Phage shock protein A
HV030_RS22430	COG3789	protein conserved in bacteria
HV030_RS22435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV030_RS22440	COG0557	exoribonuclease II activity
HV030_RS22455	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV030_RS22460	COG0330	HflC and HflK could
HV030_RS22465	COG0330	HflC and HflK could
HV030_RS22470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV030_RS22475	COG1923	regulation of RNA biosynthetic process
HV030_RS22490	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV030_RS22495	COG0802	atpase or kinase
HV030_RS22500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV030_RS22500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV030_RS22505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV030_RS22540	COG1511	domain protein
HV030_RS22540	COG3264	Mechanosensitive ion channel
HV030_RS22555	COG1053	succinate dehydrogenase
HV030_RS22560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV030_RS22605	COG1509	lysine 2,3-aminomutase activity
HV030_RS22630	COG0531	amino acid
HV030_RS22635	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV030_RS22640	COG1027	Aspartate ammonia-lyase
HV030_RS22645	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV030_RS22660	COG1309	transcriptional regulator
HV030_RS22680	COG0582	viral genome integration into host DNA
HV030_RS22690	COG3547	Transposase (IS116 IS110 IS902 family)
HV030_RS22730	COG1484	DNA-dependent DNA replication
HV030_RS22755	COG0242	peptide deformylase activity
HV030_RS22765	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV030_RS22775	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HV030_RS22780	COG3039	Transposase
HV030_RS22795	COG0789	Transcriptional regulator
HV030_RS22800	COG0789	Transcriptional regulator
HV030_RS22810	COG1230	cation diffusion facilitator family transporter
HV030_RS22815	COG0640	Transcriptional regulator
HV030_RS22905	COG1227	inorganic diphosphatase activity
HV030_RS22915	COG0148	phosphopyruvate hydratase activity
HV030_RS22925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HV030_RS22935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV030_RS22945	COG2205	protein histidine kinase activity
HV030_RS22950	COG0745	RESPONSE REGULATOR receiver
HV030_RS23095	COG2003	Belongs to the UPF0758 family
HV030_RS23160	COG3290	protein histidine kinase activity
HV030_RS23165	COG4565	transcriptional regulatory protein
HV030_RS23170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV030_RS23175	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV030_RS23175	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV030_RS23180	COG3647	Membrane
HV030_RS23185	COG2211	Major facilitator Superfamily
HV030_RS23190	COG1486	melibiose metabolic process
HV030_RS23195	COG2169	Transcriptional regulator
HV030_RS23200	COG1982	Orn Lys Arg decarboxylase major
HV030_RS23205	COG2207	Transcriptional regulator
HV030_RS23220	COG0745	RESPONSE REGULATOR receiver
HV030_RS23250	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV030_RS23255	COG2824	Alkylphosphonate utilization operon protein PhnA
HV030_RS23260	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV030_RS23265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV030_RS23270	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV030_RS23275	COG3639	organic phosphonate transmembrane transporter activity
HV030_RS23280	COG2188	Transcriptional regulator
HV030_RS23285	COG3624	Phosphonate C-P lyase system protein PhnG
HV030_RS23290	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV030_RS23295	COG3626	phosphonate metabolism
HV030_RS23300	COG3627	carbon phosphorus lyase activity
HV030_RS23305	COG4107	phosphonate C-P lyase system protein PhnK
HV030_RS23310	COG4778	phosphonate C-P lyase system protein PhnL
HV030_RS23315	COG3454	Phosphonate metabolism
HV030_RS23320	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV030_RS23325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV030_RS23350	COG1129	ABC transporter
HV030_RS23355	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS23410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV030_RS23415	COG0745	RESPONSE REGULATOR receiver
HV030_RS23425	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV030_RS23430	COG1301	dicarboxylic acid transport
HV030_RS23435	COG4235	cytochrome complex assembly
HV030_RS23440	COG3088	subunit of a heme lyase
HV030_RS23445	COG1138	Cytochrome C-type biogenesis protein
HV030_RS23450	COG3301	Polysulphide reductase, NrfD
HV030_RS23455	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS23460	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV030_RS23475	COG3162	membrane
HV030_RS23490	COG0673	inositol 2-dehydrogenase activity
HV030_RS23495	COG1346	cytolysis
HV030_RS23500	COG1380	Effector of murein hydrolase LrgA
HV030_RS23505	COG0583	DNA-binding transcription factor activity
HV030_RS23510	COG0025	NhaP-type Na H and K H
HV030_RS23515	COG2252	PERMEase
HV030_RS23520	COG0789	Transcriptional regulator
HV030_RS23530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV030_RS23545	COG0629	single-stranded DNA binding
HV030_RS23550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV030_RS23555	COG2315	Protein conserved in bacteria
HV030_RS23560	COG3700	Belongs to the class B bacterial acid phosphatase family
HV030_RS23565	COG1448	Aminotransferase
HV030_RS23575	COG0305	Participates in initiation and elongation during chromosome replication
HV030_RS23590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV030_RS23600	COG0735	belongs to the Fur family
HV030_RS23605	COG3237	CsbD-like
HV030_RS23610	COG0534	Mate efflux family protein
HV030_RS23620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV030_RS23655	COG2182	Extracellular solute-binding protein
HV030_RS23665	COG3833	ABC-type maltose transport systems, permease component
HV030_RS23670	COG2814	Major facilitator Superfamily
HV030_RS23670	COG0477	Major facilitator Superfamily
HV030_RS23675	COG3223	Belongs to the PsiE family
HV030_RS23680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV030_RS23705	COG0527	aspartate kinase activity
HV030_RS23710	COG3541	Predicted nucleotidyltransferase
HV030_RS23720	COG4650	regulator
HV030_RS23730	COG1187	pseudouridine synthase activity
HV030_RS23745	COG3657	addiction module killer protein
HV030_RS23750	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV030_RS23775	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV030_RS23785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV030_RS23815	COG0151	Belongs to the GarS family
HV030_RS23820	COG2204	response regulator
HV030_RS23880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV030_RS23885	COG2104	thiamine diphosphate biosynthetic process
HV030_RS23900	COG1278	Cold shock
HV030_RS23910	COG0085	RNA polymerase activity
HV030_RS23915	COG0222	ribosome binding
HV030_RS23920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HV030_RS23935	COG0250	Participates in transcription elongation, termination and antitermination
HV030_RS23945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HV030_RS23980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV030_RS24040	COG0583	DNA-binding transcription factor activity
HV030_RS24055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV030_RS24075	COG2207	Transcriptional regulator
HV030_RS24085	COG0371	Dehydrogenase
HV030_RS24105	COG0527	aspartate kinase activity
HV030_RS24105	COG0460	homoserine dehydrogenase
HV030_RS24110	COG0626	cystathionine gamma-synthase activity
HV030_RS24120	COG2211	Major facilitator Superfamily
HV030_RS24130	COG0254	rRNA binding
HV030_RS24135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV030_RS24140	COG1609	Transcriptional regulator
HV030_RS24145	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV030_RS24155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HV030_RS24160	COG1575	Belongs to the MenA family. Type 1 subfamily
HV030_RS24180	COG3074	FtsZ-dependent cytokinesis
HV030_RS24185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV030_RS24195	COG1494	fructose-1,6-bisphosphatase
HV030_RS24205	COG3152	Membrane
HV030_RS24220	COG0471	metal ion transport
HV030_RS24260	COG3678	ATP-independent chaperone mediated protein folding
HV030_RS24265	COG0745	RESPONSE REGULATOR receiver
HV030_RS24270	COG2205	protein histidine kinase activity
HV030_RS24275	COG2258	MOSC domain
HV030_RS24280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV030_RS24325	COG1454	alcohol dehydrogenase
HV030_RS24340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV030_RS24375	COG0437	4 iron, 4 sulfur cluster binding
HV030_RS24380	COG2864	formate dehydrogenase
HV030_RS24390	COG0456	acetyltransferase
HV030_RS24395	COG1490	D-aminoacyl-tRNA deacylase activity
HV030_RS24405	COG1011	Hydrolase
HV030_RS24415	COG0477	Major facilitator Superfamily
HV030_RS24425	COG1063	alcohol dehydrogenase
HV030_RS24430	COG3684	Belongs to the aldolase LacD family
HV030_RS24435	COG2084	Dehydrogenase
HV030_RS24440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV030_RS24445	COG1349	DNA-binding transcription factor activity
HV030_RS24450	COG2271	Major facilitator Superfamily
HV030_RS24455	COG1082	Xylose isomerase domain protein TIM barrel
HV030_RS24460	COG2188	Transcriptional regulator
HV030_RS24475	COG3852	Histidine kinase
HV030_RS24490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV030_RS24515	COG0204	Acyl-transferase
HV030_RS24530	COG3084	Protein conserved in bacteria
HV030_RS24535	COG0746	molybdenum cofactor guanylyltransferase activity
HV030_RS24540	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV030_RS24580	COG1739	Uncharacterized protein family UPF0029
HV030_RS24605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV030_RS24620	COG0805	protein transport
HV030_RS24640	COG3165	ubiquinone biosynthetic process from chorismate
HV030_RS24665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV030_RS24670	COG0583	DNA-binding transcription factor activity
HV030_RS24675	COG0697	spore germination
HV030_RS24680	COG0561	phosphatase activity
HV030_RS24685	COG2267	carboxylic ester hydrolase activity
HV030_RS24690	COG1280	lysine exporter protein (LysE YggA)
HV030_RS24695	COG1280	lysine exporter protein (LysE YggA)
HV030_RS24705	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HV030_RS24715	COG2962	Rard protein
HV030_RS24720	COG0598	Magnesium transport protein CorA
HV030_RS24730	COG1011	Hydrolase
HV030_RS24750	COG5567	small periplasmic lipoprotein
HV030_RS24775	COG2959	enzyme of heme biosynthesis
HV030_RS24780	COG3071	HemY protein
HV030_RS24825	COG2244	polysaccharide biosynthetic process
HV030_RS24830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV030_RS24835	COG0456	acetyltransferase
HV030_RS24840	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV030_RS24845	COG1088	dTDP-glucose 4,6-dehydratase activity
HV030_RS24850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV030_RS24855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV030_RS24865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV030_RS24870	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV030_RS24880	COG3118	belongs to the thioredoxin family
HV030_RS24915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV030_RS24930	COG3978	acetolactate synthase activity
HV030_RS24950	COG3085	chromosome segregation
HV030_RS24990	COG2186	Transcriptional regulator
HV030_RS24995	COG0477	Major facilitator Superfamily
HV030_RS25000	COG1609	Transcriptional regulator
HV030_RS25005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV030_RS25015	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV030_RS25020	COG1129	ABC transporter
HV030_RS25025	COG1869	D-ribose catabolic process
HV030_RS25050	COG1522	sequence-specific DNA binding
HV030_RS25055	COG0716	FMN binding
HV030_RS25070	COG3312	ion transport
HV030_RS25095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV030_RS25100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HV030_RS25110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV030_RS25130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HV030_RS25135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV030_RS25140	COG0573	inorganic phosphate transmembrane transporter activity
HV030_RS25145	COG0581	inorganic phosphate transmembrane transporter activity
HV030_RS25155	COG0704	Plays a role in the regulation of phosphate uptake
HV030_RS25160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV030_RS25165	COG2252	PERMEase
HV030_RS25170	COG0431	NADPH-dependent FMN reductase
HV030_RS25175	COG2091	lysine biosynthetic process via aminoadipic acid
HV030_RS25210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV030_RS25240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HV030_RS25250	COG3706	GGDEF domain
HV030_RS25275	COG2610	gluconate transmembrane transporter activity
HV030_RS25280	COG3622	Belongs to the hyi family
HV030_RS25285	COG0235	Class ii aldolase
HV030_RS25290	COG3395	kinase activity
HV030_RS25295	COG2084	Dehydrogenase
HV030_RS25300	COG1349	DNA-binding transcription factor activity
HV030_RS25340	COG3039	Transposase
HV030_RS25450	COG0629	single-stranded DNA binding
HV030_RS25740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV030_RS25795	COG2948	multi-organism process
HV030_RS25805	COG0583	DNA-binding transcription factor activity
HV030_RS25810	COG1846	Transcriptional regulator
HV030_RS25830	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HV030_RS25845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV030_RS25855	COG0583	DNA-binding transcription factor activity
HV030_RS25870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV030_RS25875	COG0625	glutathione transferase activity