locus-tag	class	description
HV178_RS00010	COG0592	DNA-directed DNA polymerase activity
HV178_RS00025	COG0561	phosphatase activity
HV178_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV178_RS00040	COG5645	(Lipo)protein
HV178_RS00080	COG2207	Transcriptional regulator
HV178_RS00085	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV178_RS00090	COG3119	arylsulfatase activity
HV178_RS00095	COG2149	membrane
HV178_RS00105	COG0641	radical SAM
HV178_RS00115	COG2610	gluconate transmembrane transporter activity
HV178_RS00120	COG0583	DNA-binding transcription factor activity
HV178_RS00130	COG2814	Major facilitator Superfamily
HV178_RS00150	COG0028	Belongs to the TPP enzyme family
HV178_RS00155	COG0440	acetolactate synthase activity
HV178_RS00160	COG1349	DNA-binding transcription factor activity
HV178_RS00170	COG0738	Major facilitator superfamily
HV178_RS00180	COG2197	response regulator
HV178_RS00210	COG3620	sequence-specific DNA binding
HV178_RS00220	COG2723	6-phospho-beta-galactosidase activity
HV178_RS00245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS00245	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS00250	COG3715	PTS system
HV178_RS00255	COG3716	PTS system mannose fructose sorbose family IID component
HV178_RS00275	COG1464	Belongs to the NlpA lipoprotein family
HV178_RS00280	COG0697	spore germination
HV178_RS00290	COG0604	alcohol dehydrogenase
HV178_RS00295	COG0583	DNA-binding transcription factor activity
HV178_RS00315	COG2771	luxR family
HV178_RS00360	COG2211	Major facilitator Superfamily
HV178_RS00365	COG1501	Belongs to the glycosyl hydrolase 31 family
HV178_RS00370	COG3711	transcriptional antiterminator
HV178_RS00375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS00375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS00375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS00380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS00385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS00385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS00395	COG0191	fructose-bisphosphate aldolase activity
HV178_RS00405	COG2982	Protein involved in outer membrane biogenesis
HV178_RS00410	COG2233	PERMEase
HV178_RS00415	COG0786	glutamate:sodium symporter activity
HV178_RS00420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV178_RS00425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV178_RS00430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV178_RS00450	COG2860	membrane
HV178_RS00455	COG1561	YicC-like family, N-terminal region
HV178_RS00480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV178_RS00495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV178_RS00510	COG1519	Transferase
HV178_RS00515	COG0438	transferase activity, transferring glycosyl groups
HV178_RS00520	COG0515	serine threonine protein kinase
HV178_RS00525	COG1442	glycosyl transferase family 8
HV178_RS00530	COG1442	glycosyl transferase family 8
HV178_RS00540	COG0859	PFAM glycosyl transferase family 9
HV178_RS00545	COG1215	transferase activity, transferring glycosyl groups
HV178_RS00550	COG3307	-O-antigen
HV178_RS00560	COG0859	PFAM glycosyl transferase family 9
HV178_RS00570	COG0156	8-amino-7-oxononanoate synthase activity
HV178_RS00580	COG1216	Glycosyl transferase, family 2
HV178_RS00585	COG2861	carbohydrate metabolic process
HV178_RS00590	COG4942	peptidase
HV178_RS00600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV178_RS00605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV178_RS00620	COG1045	serine acetyltransferase
HV178_RS00625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV178_RS00630	COG2271	Major facilitator Superfamily
HV178_RS00640	COG2186	Transcriptional regulator
HV178_RS00660	COG3722	fumarate hydratase activity
HV178_RS00670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS00670	COG2213	PTS system mannitol-specific
HV178_RS00680	COG1566	PFAM secretion protein HlyD family protein
HV178_RS00695	COG3501	Rhs element vgr protein
HV178_RS00725	COG3501	Rhs element vgr protein
HV178_RS00730	COG0625	glutathione transferase activity
HV178_RS00740	COG3276	selenocysteine insertion sequence binding
HV178_RS00745	COG1454	alcohol dehydrogenase
HV178_RS00750	COG1012	belongs to the aldehyde dehydrogenase family
HV178_RS00760	COG1566	PFAM secretion protein HlyD family protein
HV178_RS00765	COG0583	DNA-binding transcription factor activity
HV178_RS00770	COG3713	MltA-interacting MipA family protein
HV178_RS00780	COG2211	Major facilitator Superfamily
HV178_RS00785	COG1917	Cupin 2, conserved barrel domain protein
HV178_RS00785	COG4977	sequence-specific DNA binding
HV178_RS00790	COG0235	Class ii aldolase
HV178_RS00795	COG3623	hexulose-6-phosphate isomerase
HV178_RS00800	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV178_RS00805	COG1070	Carbohydrate kinase
HV178_RS00810	COG2271	Major facilitator Superfamily
HV178_RS00820	COG2731	YhcH YjgK YiaL family protein
HV178_RS00830	COG1414	Transcriptional regulator
HV178_RS00835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV178_RS00840	COG3977	Valine--pyruvate aminotransferase
HV178_RS00845	COG0366	Alpha amylase catalytic
HV178_RS00850	COG2992	FlgJ-related protein
HV178_RS00855	COG1609	Transcriptional regulator
HV178_RS00855	COG2207	Transcriptional regulator
HV178_RS00865	COG1070	Carbohydrate kinase
HV178_RS00870	COG4682	membrane
HV178_RS00875	COG3274	enterobacterial common antigen metabolic process
HV178_RS00900	COG1278	Cold shock
HV178_RS00905	COG2944	sequence-specific DNA binding
HV178_RS00925	COG2814	Major facilitator Superfamily
HV178_RS00930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS00940	COG1609	Transcriptional regulator
HV178_RS00945	COG2885	chlorophyll binding
HV178_RS00950	COG0243	molybdopterin cofactor binding
HV178_RS00955	COG0456	acetyltransferase
HV178_RS00960	COG2818	Glycosylase
HV178_RS00965	COG5571	outer membrane autotransporter
HV178_RS00970	COG2223	nitrite transmembrane transporter activity
HV178_RS01000	COG0747	negative chemotaxis
HV178_RS01005	COG0601	transmembrane transport
HV178_RS01010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV178_RS01015	COG0444	Belongs to the ABC transporter superfamily
HV178_RS01020	COG4608	Belongs to the ABC transporter superfamily
HV178_RS01025	COG2204	response regulator
HV178_RS01030	COG0814	amino acid
HV178_RS01035	COG0626	cystathionine gamma-synthase activity
HV178_RS01045	COG2199	diguanylate cyclase activity
HV178_RS01045	COG2200	EAL domain
HV178_RS01060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS01065	COG2200	EAL domain
HV178_RS01070	COG2982	Protein involved in outer membrane biogenesis
HV178_RS01075	COG0477	Major facilitator Superfamily
HV178_RS01080	COG1295	ribonuclease BN
HV178_RS01085	COG0583	DNA-binding transcription factor activity
HV178_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS01100	COG2200	EAL domain
HV178_RS01105	COG2197	response regulator
HV178_RS01115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV178_RS01130	COG1858	cytochrome C peroxidase
HV178_RS01135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV178_RS01140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV178_RS01145	COG0339	signal peptide processing
HV178_RS01160	COG1959	2 iron, 2 sulfur cluster binding
HV178_RS01170	COG0589	response to stress
HV178_RS01180	COG0306	phosphate transporter
HV178_RS01185	COG2081	HI0933 family
HV178_RS01190	COG2239	Acts as a magnesium transporter
HV178_RS01195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS01200	COG0842	Transport permease protein
HV178_RS01200	COG1129	ABC transporter
HV178_RS01205	COG0842	Transport permease protein
HV178_RS01225	COG2091	lysine biosynthetic process via aminoadipic acid
HV178_RS01230	COG0628	permease
HV178_RS01235	COG0477	Major facilitator Superfamily
HV178_RS01245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV178_RS01260	COG3714	YhhN family
HV178_RS01270	COG3776	membrane
HV178_RS01275	COG0742	ribosomal rna small subunit methyltransferase
HV178_RS01280	COG0552	protein localization to endoplasmic reticulum
HV178_RS01285	COG2884	Cell division ATP-binding protein ftsE
HV178_RS01290	COG2177	Part of the ABC transporter FtsEX involved in
HV178_RS01310	COG0683	leucine binding
HV178_RS01320	COG4177	L-phenylalanine transmembrane transporter activity
HV178_RS01325	COG0411	ABC transporter
HV178_RS01375	COG0584	glycerophosphoryl diester phosphodiesterase
HV178_RS01385	COG0405	Gamma-glutamyltransferase
HV178_RS01405	COG3157	Type VI secretion system effector, Hcp
HV178_RS01415	COG1247	-acetyltransferase
HV178_RS01420	COG0673	inositol 2-dehydrogenase activity
HV178_RS01425	COG1741	Belongs to the pirin family
HV178_RS01430	COG1609	Transcriptional regulator
HV178_RS01435	COG3265	gluconokinase activity
HV178_RS01440	COG2610	gluconate transmembrane transporter activity
HV178_RS01455	COG2095	MarC family integral membrane protein
HV178_RS01460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV178_RS01485	COG0058	SHG alpha-glucan phosphorylase activity
HV178_RS01490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV178_RS01505	COG1349	DNA-binding transcription factor activity
HV178_RS01515	COG0058	SHG alpha-glucan phosphorylase activity
HV178_RS01520	COG1640	4-alpha-glucanotransferase
HV178_RS01525	COG2610	gluconate transmembrane transporter activity
HV178_RS01535	COG1040	competence protein
HV178_RS01560	COG1918	ferrous iron import across plasma membrane
HV178_RS01565	COG2183	response to ionizing radiation
HV178_RS01570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV178_RS01575	COG0745	RESPONSE REGULATOR receiver
HV178_RS01590	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV178_RS01600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV178_RS01605	COG1011	Hydrolase
HV178_RS01615	COG0494	nUDIX hydrolase
HV178_RS01620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV178_RS01625	COG4972	Pilus assembly protein
HV178_RS01630	COG3166	PFAM Fimbrial assembly family protein
HV178_RS01645	COG4796	Type ii and iii secretion system protein
HV178_RS01660	COG3266	domain, Protein
HV178_RS01665	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV178_RS01670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV178_RS01680	COG0180	Tryptophanyl-tRNA synthetase
HV178_RS01685	COG2188	Transcriptional regulator
HV178_RS01695	COG3457	Alanine racemase
HV178_RS01700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HV178_RS01705	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HV178_RS01720	COG0626	cystathionine gamma-synthase activity
HV178_RS01740	COG2146	nitrite reductase [NAD(P)H] activity
HV178_RS01745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV178_RS01770	COG0512	Glutamine amidotransferase of anthranilate synthase
HV178_RS01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV178_RS01780	COG1289	transmembrane transporter activity
HV178_RS01790	COG1765	OsmC-like protein
HV178_RS01795	COG3954	Phosphoribulokinase
HV178_RS01805	COG0429	hydrolase of the alpha beta-hydrolase fold
HV178_RS01815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HV178_RS01825	COG0488	(ABC) transporter
HV178_RS01840	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV178_RS01845	COG1047	Peptidyl-prolyl cis-trans
HV178_RS01855	COG0545	Peptidyl-prolyl cis-trans isomerase
HV178_RS01860	COG2964	Protein conserved in bacteria
HV178_RS01885	COG0049	tRNA binding
HV178_RS01915	COG0051	transcription antitermination factor activity, RNA binding
HV178_RS01925	COG0088	Forms part of the polypeptide exit tunnel
HV178_RS01940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV178_RS02015	COG0200	Binds to the 23S rRNA
HV178_RS02020	COG0201	protein transport
HV178_RS02035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV178_RS02060	COG0789	Transcriptional regulator
HV178_RS02065	COG3036	rescue of stalled ribosome
HV178_RS02075	COG0569	domain protein
HV178_RS02090	COG0242	peptide deformylase activity
HV178_RS02095	COG0758	DNA mediated transformation
HV178_RS02105	COG0551	DNA topoisomerase type I activity
HV178_RS02125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV178_RS02165	COG1126	abc transporter atp-binding protein
HV178_RS02170	COG0765	amino acid transport
HV178_RS02175	COG4597	amino acid ABC transporter
HV178_RS02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV178_RS02190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV178_RS02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS02200	COG1309	transcriptional regulator
HV178_RS02210	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV178_RS02235	COG4145	pantothenate transmembrane transporter activity
HV178_RS02240	COG3924	membrane
HV178_RS02245	COG0439	Biotin carboxylase
HV178_RS02250	COG0511	ligase activity, forming carbon-carbon bonds
HV178_RS02265	COG0604	alcohol dehydrogenase
HV178_RS02270	COG2200	EAL domain
HV178_RS02270	COG2199	diguanylate cyclase activity
HV178_RS02280	COG1077	Cell shape determining protein MreB Mrl
HV178_RS02285	COG1792	Involved in formation and maintenance of cell shape
HV178_RS02290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV178_RS02300	COG1530	ribonuclease E activity
HV178_RS02305	COG3164	Protein of unknown function
HV178_RS02310	COG0312	modulator of DNA gyrase
HV178_RS02315	COG0583	DNA-binding transcription factor activity
HV178_RS02335	COG2732	(Barnase) inhibitor
HV178_RS02355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV178_RS02360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV178_RS02365	COG3105	Protein conserved in bacteria
HV178_RS02370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV178_RS02385	COG0625	glutathione transferase activity
HV178_RS02390	COG2969	positive regulation of protein catabolic process
HV178_RS02395	COG3069	C4-dicarboxylate transmembrane transporter activity
HV178_RS02420	COG2731	YhcH YjgK YiaL family protein
HV178_RS02425	COG0402	S-adenosylhomocysteine deaminase activity
HV178_RS02430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV178_RS02435	COG4804	nuclease activity
HV178_RS02440	COG0493	'glutamate synthase
HV178_RS02445	COG0070	glutamate synthase
HV178_RS02445	COG0069	glutamate synthase activity
HV178_RS02445	COG0067	glutamate synthase
HV178_RS02450	COG1242	4 iron, 4 sulfur cluster binding
HV178_RS02455	COG2198	Histidine kinase
HV178_RS02455	COG5002	protein histidine kinase activity
HV178_RS02455	COG0784	Response regulator, receiver
HV178_RS02460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV178_RS02470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS02485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV178_RS02495	COG1137	ATPase activity
HV178_RS02500	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV178_RS02505	COG3117	lipopolysaccharide transmembrane transporter activity
HV178_RS02510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV178_RS02520	COG0530	calcium, potassium:sodium antiporter activity
HV178_RS02525	COG1127	ABC transporter
HV178_RS02530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV178_RS02535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV178_RS02540	COG2854	intermembrane phospholipid transfer
HV178_RS02545	COG3113	response to antibiotic
HV178_RS02550	COG5007	Belongs to the BolA IbaG family
HV178_RS02560	COG3423	Transcriptional regulator
HV178_RS02565	COG0142	geranyltranstransferase activity
HV178_RS02570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV178_RS02575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV178_RS02580	COG0697	spore germination
HV178_RS02590	COG2027	D-alanyl-D-alanine carboxypeptidase
HV178_RS02600	COG1534	Rna-binding protein
HV178_RS02610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV178_RS02615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV178_RS02625	COG3069	C4-dicarboxylate transmembrane transporter activity
HV178_RS02630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV178_RS02635	COG0583	DNA-binding transcription factor activity
HV178_RS02640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV178_RS02665	COG0195	Participates in both transcription termination and antitermination
HV178_RS02670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV178_RS02675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV178_RS02705	COG0513	Belongs to the DEAD box helicase family
HV178_RS02710	COG0814	amino acid
HV178_RS02715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV178_RS02720	COG0826	peptidase U32
HV178_RS02725	COG0826	peptidase U32
HV178_RS02730	COG3154	lipid carrier protein
HV178_RS02735	COG3153	acetyltransferase
HV178_RS02750	COG0702	epimerase
HV178_RS02755	COG2823	Periplasmic or secreted lipoprotein
HV178_RS02775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV178_RS02790	COG1063	alcohol dehydrogenase
HV178_RS02795	COG3775	system Galactitol-specific IIC component
HV178_RS02800	COG3414	Phosphotransferase system galactitol-specific IIB component
HV178_RS02805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS02820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS02820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS02825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS02825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS02825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS02830	COG1105	Belongs to the carbohydrate kinase PfkB family
HV178_RS02840	COG1349	DNA-binding transcription factor activity
HV178_RS02845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS02850	COG2721	sulfolactate sulfo-lyase activity
HV178_RS02855	COG2271	Major facilitator Superfamily
HV178_RS02865	COG2084	Dehydrogenase
HV178_RS02870	COG1929	Belongs to the glycerate kinase type-1 family
HV178_RS02885	COG0583	DNA-binding transcription factor activity
HV178_RS02905	COG1882	Formate acetyltransferase
HV178_RS02910	COG0251	oxidation-reduction process
HV178_RS02915	COG1760	l-serine dehydratase
HV178_RS02920	COG0814	amino acid
HV178_RS02935	COG1741	Belongs to the pirin family
HV178_RS02940	COG0583	DNA-binding transcription factor activity
HV178_RS02945	COG3152	Membrane
HV178_RS02950	COG0435	Glutathione S-transferase
HV178_RS02955	COG2259	Doxx family
HV178_RS02965	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV178_RS02970	COG4575	ribosome binding
HV178_RS02975	COG1422	Protein of unknown function (DUF1090)
HV178_RS02985	COG0586	Pfam SNARE associated Golgi protein
HV178_RS02990	COG2186	Transcriptional regulator
HV178_RS02995	COG2271	Major facilitator Superfamily
HV178_RS03005	COG2721	sulfolactate sulfo-lyase activity
HV178_RS03025	COG0673	inositol 2-dehydrogenase activity
HV178_RS03030	COG1451	nucleotide metabolic process
HV178_RS03040	COG1902	pentaerythritol trinitrate reductase activity
HV178_RS03040	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV178_RS03045	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HV178_RS03045	COG3408	Glycogen debranching enzyme
HV178_RS03055	COG0531	amino acid
HV178_RS03060	COG2731	YhcH YjgK YiaL family protein
HV178_RS03065	COG3250	beta-galactosidase activity
HV178_RS03070	COG1609	Transcriptional regulator
HV178_RS03075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV178_RS03085	COG0840	transmembrane signaling receptor activity
HV178_RS03090	COG1695	Transcriptional regulator
HV178_RS03095	COG2375	cellular response to nickel ion
HV178_RS03105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV178_RS03180	COG4771	TonB-dependent receptor
HV178_RS03185	COG3391	amine dehydrogenase activity
HV178_RS03195	COG0358	DNA primase activity
HV178_RS03200	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV178_RS03205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV178_RS03215	COG4804	nuclease activity
HV178_RS03220	COG2003	Belongs to the UPF0758 family
HV178_RS03235	COG1475	DNA binding
HV178_RS03250	COG5489	Protein of unknown function (DUF736)
HV178_RS03295	COG4959	Type IV secretory pathway protease TraF
HV178_RS03315	COG1127	ABC transporter
HV178_RS03320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV178_RS03355	COG0583	DNA-binding transcription factor activity
HV178_RS03365	COG2076	Multidrug Resistance protein
HV178_RS03395	COG4962	Type ii secretion system protein e
HV178_RS03400	COG3838	Conjugal transfer protein Trbc
HV178_RS03410	COG3451	type IV secretory pathway VirB4
HV178_RS03425	COG3846	protein secretion by the type IV secretion system
HV178_RS03450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV178_RS03460	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV178_RS03490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS03495	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS03510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV178_RS03525	COG4991	sh3 domain protein
HV178_RS03530	COG3025	triphosphatase activity
HV178_RS03545	COG2268	Band 7 protein
HV178_RS03550	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV178_RS03570	COG3539	Fimbrial protein
HV178_RS03575	COG3121	Chaperone
HV178_RS03580	COG3188	usher protein
HV178_RS03585	COG3539	Fimbrial protein
HV178_RS03610	COG3384	dioxygenase
HV178_RS03615	COG0754	glutathionylspermidine amidase activity
HV178_RS03625	COG1538	Outer membrane efflux protein
HV178_RS03630	COG0494	nUDIX hydrolase
HV178_RS03635	COG3151	Protein conserved in bacteria
HV178_RS03640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV178_RS03645	COG3150	esterase
HV178_RS03650	COG0187	DNA topoisomerase II activity
HV178_RS03655	COG4977	sequence-specific DNA binding
HV178_RS03655	COG1917	Cupin 2, conserved barrel domain protein
HV178_RS03665	COG2211	Major facilitator Superfamily
HV178_RS03670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV178_RS03675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV178_RS03680	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV178_RS03705	COG3111	PFAM Bacterial OB fold (BOF) protein
HV178_RS03725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV178_RS03740	COG0471	metal ion transport
HV178_RS03745	COG0656	L-ascorbic acid biosynthetic process
HV178_RS03750	COG1979	alcohol dehydrogenase
HV178_RS03755	COG2207	Transcriptional regulator
HV178_RS03760	COG0586	Pfam SNARE associated Golgi protein
HV178_RS03765	COG0626	cystathionine gamma-synthase activity
HV178_RS03775	COG0848	biopolymer transport protein
HV178_RS03795	COG0667	Aldo Keto reductase
HV178_RS03805	COG0840	transmembrane signaling receptor activity
HV178_RS03815	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV178_RS03820	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS03825	COG5557	Pfam Polysulphide reductase, NrfD
HV178_RS03830	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV178_RS03835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV178_RS03840	COG1773	rubredoxin
HV178_RS03850	COG0298	carbon dioxide binding
HV178_RS03855	COG0625	glutathione transferase activity
HV178_RS03860	COG0243	molybdopterin cofactor binding
HV178_RS03865	COG0754	glutathionylspermidine amidase activity
HV178_RS03875	COG1811	Na channel or pump
HV178_RS03880	COG1982	Orn Lys Arg decarboxylase major
HV178_RS03885	COG2211	Major facilitator Superfamily
HV178_RS03900	COG1194	a g-specific adenine glycosylase
HV178_RS03910	COG3171	Protein conserved in bacteria
HV178_RS03920	COG0252	asparaginase activity
HV178_RS03930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV178_RS03945	COG0762	integral membrane protein
HV178_RS03950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV178_RS03955	COG2805	Type II/IV secretion system protein
HV178_RS03970	COG0189	ligase activity
HV178_RS03975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV178_RS03980	COG2356	endonuclease I
HV178_RS03990	COG2814	Major facilitator Superfamily
HV178_RS04010	COG1166	arginine decarboxylase activity
HV178_RS04020	COG0501	Belongs to the peptidase M48B family
HV178_RS04025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV178_RS04030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS04035	COG2213	PTS system mannitol-specific
HV178_RS04040	COG1063	alcohol dehydrogenase
HV178_RS04045	COG1494	fructose-1,6-bisphosphatase
HV178_RS04055	COG1072	(Pantothenic acid kinase))
HV178_RS04065	COG1122	ATPase activity
HV178_RS04095	COG0191	fructose-bisphosphate aldolase activity
HV178_RS04100	COG0549	Belongs to the carbamate kinase family
HV178_RS04105	COG2271	Major facilitator Superfamily
HV178_RS04110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV178_RS04115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV178_RS04125	COG0583	DNA-binding transcription factor activity
HV178_RS04130	COG0668	transmembrane transport
HV178_RS04135	COG1279	arginine transmembrane transporter activity
HV178_RS04140	COG2968	Membrane
HV178_RS04145	COG0583	DNA-binding transcription factor activity
HV178_RS04150	COG0427	acetyl-CoA hydrolase
HV178_RS04155	COG1024	Enoyl-CoA hydratase
HV178_RS04160	COG1703	isobutyryl-CoA mutase activity
HV178_RS04165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV178_RS04165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV178_RS04180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV178_RS04185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV178_RS04205	COG0006	proline dipeptidase activity
HV178_RS04210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV178_RS04215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV178_RS04235	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS04240	COG3501	Rhs element vgr protein
HV178_RS04275	COG2723	6-phospho-beta-galactosidase activity
HV178_RS04280	COG1737	Transcriptional regulator
HV178_RS04290	COG1272	protein, Hemolysin III
HV178_RS04300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV178_RS04325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV178_RS04345	COG4942	peptidase
HV178_RS04360	COG0457	Tetratricopeptide repeat
HV178_RS04365	COG0726	polysaccharide deacetylase
HV178_RS04365	COG1649	PFAM Uncharacterised BCR, COG1649
HV178_RS04370	COG1215	transferase activity, transferring glycosyl groups
HV178_RS04380	COG3592	Divergent 4Fe-4S mono-cluster
HV178_RS04385	COG2388	GCN5-related N-acetyl-transferase
HV178_RS04390	COG0583	DNA-binding transcription factor activity
HV178_RS04395	COG0666	response to abiotic stimulus
HV178_RS04405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV178_RS04410	COG1304	FMN binding
HV178_RS04420	COG0549	Belongs to the carbamate kinase family
HV178_RS04425	COG0402	S-adenosylhomocysteine deaminase activity
HV178_RS04440	COG0814	amino acid
HV178_RS04455	COG0183	Belongs to the thiolase family
HV178_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS04470	COG2814	Major facilitator Superfamily
HV178_RS04480	COG1794	racemase activity, acting on amino acids and derivatives
HV178_RS04485	COG0583	DNA-binding transcription factor activity
HV178_RS04495	COG1609	Transcriptional regulator
HV178_RS04515	COG0667	Aldo Keto reductase
HV178_RS04525	COG0861	Integral membrane protein TerC family
HV178_RS04555	COG2165	general secretion pathway protein
HV178_RS04560	COG4795	General secretion pathway protein
HV178_RS04570	COG4967	type IV pilus modification protein PilV
HV178_RS04575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV178_RS04585	COG1074	ATP-dependent DNA helicase activity
HV178_RS04590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV178_RS04595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV178_RS04595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV178_RS04600	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV178_RS04620	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV178_RS04625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV178_RS04630	COG2166	iron-sulfur cluster assembly
HV178_RS04635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV178_RS04645	COG0583	DNA-binding transcription factor activity
HV178_RS04650	COG2363	Small membrane protein
HV178_RS04660	COG1349	DNA-binding transcription factor activity
HV178_RS04670	COG1070	Carbohydrate kinase
HV178_RS04680	COG1129	ABC transporter
HV178_RS04685	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS04695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV178_RS04705	COG0235	Class ii aldolase
HV178_RS04710	COG1454	alcohol dehydrogenase
HV178_RS04720	COG1760	l-serine dehydratase
HV178_RS04725	COG0814	amino acid
HV178_RS04730	COG1611	Belongs to the LOG family
HV178_RS04745	COG3098	single-species biofilm formation
HV178_RS04750	COG0564	pseudouridine synthase activity
HV178_RS04755	COG0716	FMN binding
HV178_RS04760	COG2271	Major facilitator Superfamily
HV178_RS04765	COG4948	Mandelate Racemase Muconate Lactonizing
HV178_RS04770	COG4948	Mandelate Racemase Muconate Lactonizing
HV178_RS04775	COG1929	Belongs to the glycerate kinase type-1 family
HV178_RS04780	COG2205	protein histidine kinase activity
HV178_RS04780	COG3850	Histidine kinase
HV178_RS04780	COG4999	Histidine kinase
HV178_RS04780	COG3437	response regulator, receiver
HV178_RS04790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV178_RS04795	COG3956	TIGRFAM MazG family protein
HV178_RS04830	COG1737	Transcriptional regulator
HV178_RS04835	COG2190	(PTS) system
HV178_RS04835	COG1263	PTS System
HV178_RS04835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS04840	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV178_RS04845	COG0602	queuosine metabolic process
HV178_RS04850	COG0720	synthase
HV178_RS04870	COG2234	aminopeptidase activity
HV178_RS04925	COG4942	peptidase
HV178_RS04925	COG1388	LysM domain
HV178_RS04940	COG0163	prenyltransferase activity
HV178_RS04945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV178_RS04970	COG0628	permease
HV178_RS04975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV178_RS04995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV178_RS05000	COG1882	Formate acetyltransferase
HV178_RS05015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV178_RS05020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV178_RS05025	COG1121	(ABC) transporter
HV178_RS05045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV178_RS05050	COG1737	Transcriptional regulator
HV178_RS05055	COG3069	C4-dicarboxylate transmembrane transporter activity
HV178_RS05075	COG0309	Hydrogenase expression formation protein (HypE)
HV178_RS05080	COG0409	Hydrogenase expression formation protein
HV178_RS05085	COG0298	carbon dioxide binding
HV178_RS05090	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV178_RS05095	COG0375	protein maturation
HV178_RS05105	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV178_RS05110	COG0651	ATP synthesis coupled electron transport
HV178_RS05115	COG0650	Formate hydrogenlyase subunit 4
HV178_RS05120	COG3261	NADH dehydrogenase
HV178_RS05120	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV178_RS05125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV178_RS05130	COG3260	NADH ubiquinone oxidoreductase 20
HV178_RS05140	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV178_RS05150	COG2723	6-phospho-beta-galactosidase activity
HV178_RS05155	COG1263	PTS System
HV178_RS05155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS05160	COG1609	Transcriptional regulator
HV178_RS05165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV178_RS05170	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV178_RS05190	COG0517	IMP dehydrogenase activity
HV178_RS05190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV178_RS05195	COG1349	DNA-binding transcription factor activity
HV178_RS05200	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS05215	COG3732	PTS system glucitol sorbitol-specific
HV178_RS05220	COG3730	PTS system glucitol sorbitol-specific
HV178_RS05225	COG2951	lytic endotransglycosylase activity
HV178_RS05230	COG1546	Belongs to the CinA family
HV178_RS05250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV178_RS05280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV178_RS05285	COG1238	metal cluster binding
HV178_RS05305	COG2814	Major facilitator Superfamily
HV178_RS05310	COG1566	PFAM secretion protein HlyD family protein
HV178_RS05315	COG1846	Transcriptional regulator
HV178_RS05325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV178_RS05330	COG2814	Major facilitator Superfamily
HV178_RS05340	COG4176	ABC-type proline glycine betaine transport system permease component
HV178_RS05370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV178_RS05400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV178_RS05405	COG0640	Transcriptional regulator
HV178_RS05410	COG0401	homolog of Blt101
HV178_RS05415	COG1652	LysM domain
HV178_RS05420	COG1802	Transcriptional regulator
HV178_RS05425	COG1113	amino acid transport
HV178_RS05430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV178_RS05435	COG1012	belongs to the aldehyde dehydrogenase family
HV178_RS05440	COG0579	oxidoreductase
HV178_RS05450	COG1285	pathogenesis
HV178_RS05455	COG2211	Major facilitator Superfamily
HV178_RS05500	COG0642	Histidine kinase
HV178_RS05510	COG3188	usher protein
HV178_RS05515	COG3121	Chaperone
HV178_RS05560	COG0438	transferase activity, transferring glycosyl groups
HV178_RS05565	COG0297	glycogen (starch) synthase activity
HV178_RS05565	COG0438	transferase activity, transferring glycosyl groups
HV178_RS05605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV178_RS05610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV178_RS05615	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV178_RS05620	COG2271	Major facilitator Superfamily
HV178_RS05625	COG2197	response regulator
HV178_RS05630	COG0784	Response regulator, receiver
HV178_RS05630	COG2205	protein histidine kinase activity
HV178_RS05630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV178_RS05630	COG2198	Histidine kinase
HV178_RS05650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV178_RS05655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS05660	COG3065	identical protein binding
HV178_RS05675	COG3962	Belongs to the TPP enzyme family
HV178_RS05680	COG0673	inositol 2-dehydrogenase activity
HV178_RS05695	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS05715	COG3718	enzyme involved in inositol metabolism
HV178_RS05755	COG3436	PFAM IS66 Orf2 family protein
HV178_RS05760	COG4372	Transposase
HV178_RS05775	COG3111	PFAM Bacterial OB fold (BOF) protein
HV178_RS05790	COG2814	Major facilitator Superfamily
HV178_RS05840	COG4735	regulation of single-species biofilm formation
HV178_RS05855	COG4983	Phage plasmid primase, P4 family domain protein
HV178_RS05860	COG3311	Transcriptional regulator
HV178_RS05885	COG0556	nucleotide-excision repair
HV178_RS05900	COG0582	viral genome integration into host DNA
HV178_RS05910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS05935	COG2867	negative regulation of translational initiation
HV178_RS05950	COG0497	DNA recombination
HV178_RS05965	COG4536	flavin adenine dinucleotide binding
HV178_RS05970	COG4137	Cytochrome C assembly protein
HV178_RS05975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV178_RS06000	COG2885	chlorophyll binding
HV178_RS06005	COG2199	diguanylate cyclase activity
HV178_RS06020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV178_RS06025	COG1605	Chorismate mutase
HV178_RS06025	COG0287	Prephenate dehydrogenase
HV178_RS06030	COG0077	Prephenate dehydratase
HV178_RS06030	COG1605	Chorismate mutase
HV178_RS06040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV178_RS06045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV178_RS06060	COG0542	response to heat
HV178_RS06085	COG0477	Major facilitator Superfamily
HV178_RS06090	COG5544	Lipoprotein
HV178_RS06095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV178_RS06110	COG3118	belongs to the thioredoxin family
HV178_RS06115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV178_RS06140	COG0513	Belongs to the DEAD box helicase family
HV178_RS06150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV178_RS06160	COG1595	DNA-templated transcription, initiation
HV178_RS06165	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV178_RS06170	COG3026	antisigma factor binding
HV178_RS06175	COG3086	response to oxidative stress
HV178_RS06185	COG0681	Belongs to the peptidase S26 family
HV178_RS06205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV178_RS06215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV178_RS06280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HV178_RS06350	COG3179	chitinase
HV178_RS06375	COG4220	transposase activity
HV178_RS06395	COG1030	water channel activity
HV178_RS06445	COG1196	nuclear chromosome segregation
HV178_RS06505	COG1737	Transcriptional regulator
HV178_RS06510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV178_RS06515	COG1263	PTS System
HV178_RS06515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS06520	COG0560	Phosphoserine phosphatase
HV178_RS06540	COG2205	protein histidine kinase activity
HV178_RS06545	COG3170	Tfp pilus assembly protein FimV
HV178_RS06550	COG2204	response regulator
HV178_RS06555	COG0347	Belongs to the P(II) protein family
HV178_RS06560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV178_RS06560	COG1017	nitric oxide dioxygenase activity
HV178_RS06590	COG4638	Rieske (2fe-2S)
HV178_RS06595	COG0583	DNA-binding transcription factor activity
HV178_RS06600	COG1940	carbohydrate kinase activity
HV178_RS06605	COG0457	Tetratricopeptide repeat
HV178_RS06610	COG2814	Major facilitator Superfamily
HV178_RS06610	COG0477	Major facilitator Superfamily
HV178_RS06620	COG2814	Major facilitator Superfamily
HV178_RS06625	COG3711	transcriptional antiterminator
HV178_RS06630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV178_RS06630	COG0517	IMP dehydrogenase activity
HV178_RS06635	COG1069	ribulokinase activity
HV178_RS06645	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS06650	COG1129	ABC transporter
HV178_RS06660	COG3683	transport system, periplasmic component
HV178_RS06665	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV178_RS06670	COG1073	alpha beta
HV178_RS06690	COG1104	cysteine desulfurase activity
HV178_RS06695	COG0822	iron-sulfur transferase activity
HV178_RS06715	COG0633	Ferredoxin
HV178_RS06720	COG2975	iron-sulfur cluster assembly
HV178_RS06735	COG2897	thiosulfate sulfurtransferase activity
HV178_RS06740	COG2373	Large extracellular alpha-helical protein
HV178_RS06745	COG4953	penicillin-binding protein 1C
HV178_RS06760	COG1426	Protein conserved in bacteria
HV178_RS06775	COG2976	Protein conserved in bacteria
HV178_RS06790	COG3104	oligopeptide transport
HV178_RS06800	COG1645	bacterial-type flagellum-dependent swarming motility
HV178_RS06820	COG1570	exodeoxyribonuclease VII activity
HV178_RS06825	COG0517	IMP dehydrogenase activity
HV178_RS06825	COG0516	GMP reductase activity
HV178_RS06855	COG0673	inositol 2-dehydrogenase activity
HV178_RS06860	COG3732	PTS system glucitol sorbitol-specific
HV178_RS06875	COG3423	Transcriptional regulator
HV178_RS06920	COG0668	transmembrane transport
HV178_RS06930	COG2200	EAL domain
HV178_RS06935	COG0248	Ppx GppA phosphatase
HV178_RS06945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV178_RS06955	COG2723	6-phospho-beta-galactosidase activity
HV178_RS06965	COG2233	PERMEase
HV178_RS06975	COG1393	Belongs to the ArsC family
HV178_RS06980	COG4783	chaperone-mediated protein folding
HV178_RS06985	COG0628	permease
HV178_RS06990	COG3366	ferrous iron transmembrane transporter activity
HV178_RS06995	COG0700	Nucleoside recognition
HV178_RS07000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV178_RS07005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV178_RS07010	COG2716	regulation of RNA biosynthetic process
HV178_RS07020	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV178_RS07030	COG2321	neutral zinc metallopeptidase
HV178_RS07040	COG0400	carboxylic ester hydrolase activity
HV178_RS07055	COG1393	Belongs to the ArsC family
HV178_RS07065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV178_RS07070	COG3850	Histidine kinase
HV178_RS07075	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV178_RS07075	COG0493	'glutamate synthase
HV178_RS07085	COG5342	invasion associated locus B
HV178_RS07090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV178_RS07130	COG4766	ethanolamine catabolic process
HV178_RS07135	COG4812	Cobalamin adenosyltransferase
HV178_RS07195	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HV178_RS07200	COG2207	Transcriptional regulator
HV178_RS07215	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV178_RS07235	COG2837	iron assimilation
HV178_RS07250	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV178_RS07255	COG4208	sulfate ABC transporter
HV178_RS07260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV178_RS07325	COG3530	Putative quorum-sensing-regulated virulence factor
HV178_RS07330	COG0385	Bile acid
HV178_RS07335	COG0583	DNA-binding transcription factor activity
HV178_RS07345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV178_RS07350	COG2211	Major facilitator Superfamily
HV178_RS07355	COG0583	DNA-binding transcription factor activity
HV178_RS07390	COG3415	Transposase
HV178_RS07395	COG3415	Transposase
HV178_RS07410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV178_RS07425	COG0667	Aldo Keto reductase
HV178_RS07430	COG3961	Belongs to the TPP enzyme family
HV178_RS07445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS07450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS07455	COG0006	proline dipeptidase activity
HV178_RS07460	COG1363	Peptidase, m42
HV178_RS07465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV178_RS07465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS07465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS07480	COG2207	Transcriptional regulator
HV178_RS07485	COG3279	Response regulator of the LytR AlgR family
HV178_RS07490	COG3275	phosphorelay sensor kinase activity
HV178_RS07495	COG0436	Aminotransferase
HV178_RS07510	COG1560	Kdo2-lipid A biosynthetic process
HV178_RS07540	COG3122	Protein conserved in bacteria
HV178_RS07545	COG0840	transmembrane signaling receptor activity
HV178_RS07605	COG0582	viral genome integration into host DNA
HV178_RS07615	COG2116	formate transmembrane transporter activity
HV178_RS07625	COG2067	long-chain fatty acid transport protein
HV178_RS07630	COG3691	Protein conserved in bacteria
HV178_RS07645	COG2062	phosphohistidine phosphatase, SixA
HV178_RS07670	COG0730	response to heat
HV178_RS07675	COG3101	peptidyl-lysine hydroxylation
HV178_RS07690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV178_RS07710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV178_RS07720	COG0586	Pfam SNARE associated Golgi protein
HV178_RS07730	COG0285	dihydrofolate synthase activity
HV178_RS07735	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV178_RS07740	COG1286	toxin biosynthetic process
HV178_RS07745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV178_RS07750	COG0163	prenyltransferase activity
HV178_RS07760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV178_RS07765	COG4215	(ABC) transporter
HV178_RS07775	COG4598	ABC transporter
HV178_RS07780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV178_RS07785	COG1090	epimerase
HV178_RS07790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV178_RS07795	COG0625	glutathione transferase activity
HV178_RS07800	COG0625	glutathione transferase activity
HV178_RS07805	COG0622	Phosphoesterase
HV178_RS07840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV178_RS07845	COG0471	metal ion transport
HV178_RS07845	COG0490	domain, Protein
HV178_RS07855	COG0436	Aminotransferase
HV178_RS07860	COG0583	DNA-binding transcription factor activity
HV178_RS07880	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV178_RS07905	COG0839	Belongs to the complex I subunit 6 family
HV178_RS07915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV178_RS07920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV178_RS07930	COG0784	Response regulator, receiver
HV178_RS07930	COG0835	chemotaxis
HV178_RS07940	COG2153	protein acetylation
HV178_RS07945	COG4575	ribosome binding
HV178_RS07950	COG1169	isochorismate synthase
HV178_RS08035	COG1414	Transcriptional regulator
HV178_RS08045	COG2271	Major facilitator Superfamily
HV178_RS08055	COG5464	transposase or invertase
HV178_RS08060	COG0247	lactate metabolic process
HV178_RS08070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV178_RS08075	COG2271	Major facilitator Superfamily
HV178_RS08080	COG0584	glycerophosphoryl diester phosphodiesterase
HV178_RS08085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV178_RS08110	COG0183	Belongs to the thiolase family
HV178_RS08115	COG2031	fatty acid transporter
HV178_RS08120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV178_RS08125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV178_RS08130	COG2204	response regulator
HV178_RS08135	COG3852	Histidine kinase
HV178_RS08150	COG2198	Histidine kinase
HV178_RS08150	COG0642	Histidine kinase
HV178_RS08155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV178_RS08160	COG1477	protein flavinylation
HV178_RS08165	COG2169	Transcriptional regulator
HV178_RS08165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV178_RS08170	COG3145	DNA-N1-methyladenine dioxygenase activity
HV178_RS08175	COG4615	Cyclic peptide transporter
HV178_RS08180	COG2239	Acts as a magnesium transporter
HV178_RS08185	COG0659	secondary active sulfate transmembrane transporter activity
HV178_RS08200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV178_RS08200	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV178_RS08205	COG3062	negative regulation of establishment of protein localization
HV178_RS08215	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS08220	COG0348	domain, Protein
HV178_RS08225	COG3043	anaerobic respiration
HV178_RS08230	COG3005	denitrification pathway
HV178_RS08235	COG4133	protoheme IX ABC transporter activity
HV178_RS08245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV178_RS08250	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV178_RS08260	COG1138	Cytochrome C-type biogenesis protein
HV178_RS08265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV178_RS08270	COG4235	cytochrome complex assembly
HV178_RS08270	COG3088	subunit of a heme lyase
HV178_RS08275	COG2197	response regulator
HV178_RS08305	COG1061	Type III restriction enzyme res subunit
HV178_RS08310	COG1187	pseudouridine synthase activity
HV178_RS08315	COG2814	Major facilitator Superfamily
HV178_RS08325	COG4172	Belongs to the ABC transporter superfamily
HV178_RS08330	COG4239	(ABC) transporter, permease
HV178_RS08335	COG4174	ABC transporter (Permease)
HV178_RS08340	COG4166	transmembrane transport
HV178_RS08345	COG2200	EAL domain
HV178_RS08350	COG0791	NLP P60 protein
HV178_RS08355	COG0671	phosphoesterase, PA-phosphatase related
HV178_RS08360	COG0523	cobalamin synthesis protein
HV178_RS08365	COG0246	Mannitol dehydrogenase
HV178_RS08370	COG1312	Catalyzes the dehydration of D-mannonate
HV178_RS08375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV178_RS08380	COG3005	denitrification pathway
HV178_RS08390	COG3381	protein complex oligomerization
HV178_RS08415	COG1105	Belongs to the carbohydrate kinase PfkB family
HV178_RS08420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS08420	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV178_RS08420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS08425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV178_RS08435	COG0583	DNA-binding transcription factor activity
HV178_RS08440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS08445	COG2313	pseudouridylate synthase activity
HV178_RS08450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV178_RS08455	COG1522	sequence-specific DNA binding
HV178_RS08455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS08465	COG2855	membrane
HV178_RS08470	COG0583	DNA-binding transcription factor activity
HV178_RS08475	COG0833	amino acid
HV178_RS08480	COG4771	TonB-dependent receptor
HV178_RS08485	COG2271	Major facilitator Superfamily
HV178_RS08490	COG0560	Phosphoserine phosphatase
HV178_RS08495	COG1760	l-serine dehydratase
HV178_RS08515	COG2311	Membrane
HV178_RS08530	COG1129	ABC transporter
HV178_RS08545	COG0493	'glutamate synthase
HV178_RS08555	COG2949	membrane
HV178_RS08565	COG1346	cytolysis
HV178_RS08580	COG2271	Major facilitator Superfamily
HV178_RS08595	COG0625	glutathione transferase activity
HV178_RS08600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV178_RS08605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV178_RS08620	COG0586	Pfam SNARE associated Golgi protein
HV178_RS08630	COG1686	Belongs to the peptidase S11 family
HV178_RS08635	COG0277	FAD linked oxidase domain protein
HV178_RS08640	COG1472	Belongs to the glycosyl hydrolase 3 family
HV178_RS08645	COG1732	Glycine betaine
HV178_RS08650	COG1174	glycine betaine transport
HV178_RS08655	COG1125	glycine betaine transport
HV178_RS08660	COG1174	glycine betaine transport
HV178_RS08670	COG0789	Transcriptional regulator
HV178_RS08675	COG3275	phosphorelay sensor kinase activity
HV178_RS08685	COG4807	Protein conserved in bacteria
HV178_RS08690	COG4808	Protein conserved in bacteria
HV178_RS08700	COG0489	protein tyrosine kinase activity
HV178_RS08715	COG3121	Chaperone
HV178_RS08720	COG3188	usher protein
HV178_RS08730	COG5455	response to cobalt ion
HV178_RS08740	COG0351	phosphomethylpyrimidine kinase
HV178_RS08745	COG2188	Transcriptional regulator
HV178_RS08750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS08755	COG1397	ADP-ribosylglycohydrolase
HV178_RS08765	COG1830	Aldolase
HV178_RS08775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV178_RS08780	COG4160	amino acid transport
HV178_RS08785	COG4215	(ABC) transporter
HV178_RS08790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV178_RS08795	COG1126	abc transporter atp-binding protein
HV178_RS08810	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV178_RS08815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV178_RS08820	COG0702	epimerase
HV178_RS08825	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV178_RS08830	COG0028	Belongs to the TPP enzyme family
HV178_RS08840	COG4529	Protein conserved in bacteria
HV178_RS08845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV178_RS08855	COG2431	L-lysine efflux transmembrane transporter activity
HV178_RS08865	COG3593	DNA synthesis involved in DNA repair
HV178_RS08870	COG2990	Protein conserved in bacteria
HV178_RS08875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS08885	COG1278	Cold shock
HV178_RS08895	COG0542	response to heat
HV178_RS08910	COG0745	RESPONSE REGULATOR receiver
HV178_RS08915	COG2205	protein histidine kinase activity
HV178_RS08945	COG0443	Heat shock 70 kDa protein
HV178_RS08950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV178_RS08955	COG5002	protein histidine kinase activity
HV178_RS08955	COG3447	MASE1 domain protein
HV178_RS08955	COG5001	Diguanylate cyclase
HV178_RS08970	COG2982	Protein involved in outer membrane biogenesis
HV178_RS08975	COG1253	flavin adenine dinucleotide binding
HV178_RS08990	COG3206	protein involved in exopolysaccharide biosynthesis
HV178_RS08990	COG0489	protein tyrosine kinase activity
HV178_RS08995	COG0463	Glycosyl transferase, family 2
HV178_RS09000	COG1045	serine acetyltransferase
HV178_RS09005	COG0438	transferase activity, transferring glycosyl groups
HV178_RS09015	COG1216	Glycosyl transferase, family 2
HV178_RS09020	COG0110	maltose O-acetyltransferase activity
HV178_RS09025	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV178_RS09030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV178_RS09035	COG1051	belongs to the nudix hydrolase family
HV178_RS09040	COG0297	glycogen (starch) synthase activity
HV178_RS09050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV178_RS09055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV178_RS09060	COG2244	polysaccharide biosynthetic process
HV178_RS09065	COG2327	Polysaccharide pyruvyl transferase
HV178_RS09080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV178_RS09110	COG0438	transferase activity, transferring glycosyl groups
HV178_RS09125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV178_RS09140	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV178_RS09160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV178_RS09190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV178_RS09195	COG0583	DNA-binding transcription factor activity
HV178_RS09205	COG0531	amino acid
HV178_RS09210	COG2925	Exonuclease
HV178_RS09240	COG1289	transmembrane transporter activity
HV178_RS09275	COG4656	Part of a membrane complex involved in electron transport
HV178_RS09465	COG1376	ErfK ybiS ycfS ynhG family protein
HV178_RS09470	COG3842	ATPase activity
HV178_RS09475	COG1178	ABC-type Fe3 transport system permease component
HV178_RS09480	COG1840	ABC-type Fe3 transport system, periplasmic component
HV178_RS09500	COG2076	Multidrug Resistance protein
HV178_RS09505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV178_RS09510	COG1418	mRNA catabolic process
HV178_RS09515	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV178_RS09520	COG3727	T/G mismatch-specific endonuclease activity
HV178_RS09525	COG0697	spore germination
HV178_RS09530	COG2354	Protein conserved in bacteria
HV178_RS09535	COG5475	Uncharacterized small protein (DUF2158)
HV178_RS09595	COG2882	bacterial-type flagellum organization
HV178_RS09600	COG1157	protein secretion by the type III secretion system
HV178_RS09635	COG2246	polysaccharide biosynthetic process
HV178_RS09640	COG0425	Belongs to the sulfur carrier protein TusA family
HV178_RS09655	COG0366	Alpha amylase catalytic
HV178_RS09710	COG2197	response regulator
HV178_RS09720	COG2197	response regulator
HV178_RS09765	COG1305	Transglutaminase-like
HV178_RS09775	COG2608	mercury ion transmembrane transporter activity
HV178_RS09780	COG3012	SEC-C Motif Domain Protein
HV178_RS09780	COG3318	Belongs to the UPF0149 family
HV178_RS09785	COG0814	amino acid
HV178_RS09795	COG1528	Iron-storage protein
HV178_RS09820	COG1528	Iron-storage protein
HV178_RS09830	COG1879	ABC-type sugar transport system periplasmic component
HV178_RS09835	COG1129	ABC transporter
HV178_RS09840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS09855	COG0589	response to stress
HV178_RS09885	COG0835	chemotaxis
HV178_RS09890	COG1301	dicarboxylic acid transport
HV178_RS09900	COG0840	transmembrane signaling receptor activity
HV178_RS09915	COG0745	RESPONSE REGULATOR receiver
HV178_RS09940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV178_RS09955	COG3102	Protein conserved in bacteria
HV178_RS09975	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV178_RS09980	COG1801	Protein of unknown function DUF72
HV178_RS10050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV178_RS10060	COG1335	isochorismatase
HV178_RS10070	COG0494	nUDIX hydrolase
HV178_RS10110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV178_RS10120	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV178_RS10125	COG0739	heme binding
HV178_RS10130	COG1560	Kdo2-lipid A biosynthetic process
HV178_RS10140	COG1737	Transcriptional regulator
HV178_RS10145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV178_RS10150	COG0129	dihydroxy-acid dehydratase activity
HV178_RS10155	COG0800	Aldolase
HV178_RS10165	COG3141	response to X-ray
HV178_RS10175	COG2979	Protein of unknown function (DUF533)
HV178_RS10180	COG1770	oligopeptidase
HV178_RS10185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV178_RS10190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV178_RS10200	COG2372	response to copper ion
HV178_RS10205	COG1276	copper resistance
HV178_RS10215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV178_RS10235	COG3008	intermembrane lipid transfer
HV178_RS10240	COG2995	paraquat-inducible protein a
HV178_RS10245	COG1956	GAF domain-containing protein
HV178_RS10265	COG2814	Major facilitator Superfamily
HV178_RS10270	COG1414	Transcriptional regulator
HV178_RS10300	COG0768	penicillin binding
HV178_RS10305	COG2226	methyltransferase
HV178_RS10320	COG3716	PTS system mannose fructose sorbose family IID component
HV178_RS10325	COG3715	PTS system
HV178_RS10330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS10330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS10335	COG1253	flavin adenine dinucleotide binding
HV178_RS10340	COG2200	EAL domain
HV178_RS10345	COG1760	l-serine dehydratase
HV178_RS10365	COG0251	oxidation-reduction process
HV178_RS10370	COG1199	ATP-dependent helicase activity
HV178_RS10375	COG1214	PFAM Peptidase M22, glycoprotease
HV178_RS10380	COG3065	identical protein binding
HV178_RS10385	COG0318	PFAM AMP-dependent synthetase and ligase
HV178_RS10390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV178_RS10395	COG0473	3-isopropylmalate dehydrogenase activity
HV178_RS10400	COG0583	DNA-binding transcription factor activity
HV178_RS10410	COG2894	cell division
HV178_RS10425	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV178_RS10435	COG0582	viral genome integration into host DNA
HV178_RS10535	COG2246	polysaccharide biosynthetic process
HV178_RS10560	COG2719	SpoVR family
HV178_RS10570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV178_RS10580	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV178_RS10605	COG0157	Belongs to the NadC ModD family
HV178_RS10610	COG0500	methyltransferase
HV178_RS10615	COG1120	ATPase activity
HV178_RS10640	COG1461	Dihydroxyacetone kinase
HV178_RS10645	COG2376	Dihydroxyacetone kinase
HV178_RS10650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV178_RS10675	COG0789	Transcriptional regulator
HV178_RS10680	COG2200	EAL domain
HV178_RS10765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV178_RS10795	COG1396	sequence-specific DNA binding
HV178_RS10810	COG2003	Belongs to the UPF0758 family
HV178_RS10815	COG4974	Belongs to the 'phage' integrase family
HV178_RS10860	COG0582	viral genome integration into host DNA
HV178_RS10865	COG0012	GTP binding
HV178_RS10880	COG0527	aspartate kinase activity
HV178_RS10885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV178_RS10890	COG0076	glutamate decarboxylase activity
HV178_RS10895	COG0659	secondary active sulfate transmembrane transporter activity
HV178_RS10925	COG2890	protein-(glutamine-N5) methyltransferase activity
HV178_RS10930	COG3094	Invasion gene expression up-regulator, SirB
HV178_RS10945	COG0387	Pfam Sodium calcium exchanger
HV178_RS10950	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV178_RS10960	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV178_RS10965	COG4932	domain protein
HV178_RS10970	COG2197	response regulator
HV178_RS10975	COG3850	Histidine kinase
HV178_RS10980	COG2223	nitrite transmembrane transporter activity
HV178_RS10985	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV178_RS10990	COG1140	nitrate reductase beta subunit
HV178_RS10995	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV178_RS11000	COG2181	nitrate reductase activity
HV178_RS11030	COG0788	formyltetrahydrofolate deformylase activity
HV178_RS11040	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV178_RS11045	COG0745	RESPONSE REGULATOR receiver
HV178_RS11050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV178_RS11060	COG1435	thymidine kinase activity
HV178_RS11065	COG1012	belongs to the aldehyde dehydrogenase family
HV178_RS11065	COG1454	alcohol dehydrogenase
HV178_RS11070	COG2095	MarC family integral membrane protein
HV178_RS11090	COG0444	Belongs to the ABC transporter superfamily
HV178_RS11100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV178_RS11120	COG2350	Protein conserved in bacteria
HV178_RS11145	COG3047	cAMP biosynthetic process
HV178_RS11150	COG0217	transcriptional regulatory protein
HV178_RS11165	COG3706	GGDEF domain
HV178_RS11205	COG0009	L-threonylcarbamoyladenylate synthase
HV178_RS11210	COG1187	pseudouridine synthase activity
HV178_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS11225	COG0616	signal peptide processing
HV178_RS11240	COG0583	DNA-binding transcription factor activity
HV178_RS11255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV178_RS11265	COG0671	phosphoesterase, PA-phosphatase related
HV178_RS11270	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV178_RS11275	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV178_RS11285	COG0023	Translation Initiation Factor
HV178_RS11295	COG1349	DNA-binding transcription factor activity
HV178_RS11305	COG5001	Diguanylate cyclase
HV178_RS11315	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV178_RS11315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV178_RS11320	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV178_RS11340	COG4171	peptide transport system, permease
HV178_RS11365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV178_RS11370	COG1842	Phage shock protein A
HV178_RS11380	COG1983	PspC domain protein
HV178_RS11390	COG0366	Alpha amylase catalytic
HV178_RS11400	COG1175	transmembrane transport
HV178_RS11405	COG0395	ABC-type sugar transport system, permease component
HV178_RS11410	COG1063	alcohol dehydrogenase
HV178_RS11415	COG1082	Xylose isomerase domain protein TIM barrel
HV178_RS11420	COG0673	inositol 2-dehydrogenase activity
HV178_RS11425	COG1554	hydrolase, family 65, central catalytic
HV178_RS11430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV178_RS11445	COG1609	Transcriptional regulator
HV178_RS11450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV178_RS11455	COG3106	COG3106 Predicted ATPase
HV178_RS11470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV178_RS11475	COG4948	Mandelate Racemase Muconate Lactonizing
HV178_RS11480	COG2866	Carboxypeptidase
HV178_RS11485	COG4166	transmembrane transport
HV178_RS11505	COG1349	DNA-binding transcription factor activity
HV178_RS11510	COG0346	lactoylglutathione lyase activity
HV178_RS11520	COG0668	transmembrane transport
HV178_RS11525	COG3182	Iron-regulated membrane protein
HV178_RS11540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV178_RS11545	COG2840	Smr protein MutS2
HV178_RS11550	COG3706	GGDEF domain
HV178_RS11560	COG0840	transmembrane signaling receptor activity
HV178_RS11570	COG0513	Belongs to the DEAD box helicase family
HV178_RS11580	COG0589	response to stress
HV178_RS11590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV178_RS11595	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV178_RS11595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV178_RS11595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV178_RS11595	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV178_RS11600	COG3042	response to heat
HV178_RS11605	COG3187	Heat shock protein
HV178_RS11610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV178_RS11615	COG2911	Protein conserved in bacteria
HV178_RS11625	COG3784	Protein of unknown function (DUF1318)
HV178_RS11630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV178_RS11635	COG4589	Belongs to the CDS family
HV178_RS11645	COG2267	carboxylic ester hydrolase activity
HV178_RS11650	COG2453	phosphatase
HV178_RS11650	COG0671	phosphoesterase, PA-phosphatase related
HV178_RS11670	COG1643	Atp-dependent helicase
HV178_RS11675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV178_RS11680	COG1012	belongs to the aldehyde dehydrogenase family
HV178_RS11685	COG0657	acetylesterase activity
HV178_RS11685	COG2755	lipolytic protein G-D-S-L family
HV178_RS11690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV178_RS11695	COG3038	cytochrome b561
HV178_RS11705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV178_RS11710	COG2864	formate dehydrogenase
HV178_RS11715	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS11720	COG3383	formate dehydrogenase (NAD+) activity
HV178_RS11720	COG0243	molybdopterin cofactor binding
HV178_RS11730	COG3059	membrane
HV178_RS11750	COG0840	transmembrane signaling receptor activity
HV178_RS11755	COG0583	DNA-binding transcription factor activity
HV178_RS11760	COG1227	inorganic diphosphatase activity
HV178_RS11765	COG5383	Protein conserved in bacteria
HV178_RS11775	COG2841	Protein conserved in bacteria
HV178_RS11785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV178_RS11790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV178_RS11795	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV178_RS11800	COG0500	methyltransferase
HV178_RS11820	COG3135	benzoate transporter
HV178_RS11825	COG1396	sequence-specific DNA binding
HV178_RS11830	COG0826	peptidase U32
HV178_RS11845	COG1294	oxidase, subunit
HV178_RS11850	COG1271	oxidase subunit
HV178_RS11855	COG1724	mRNA binding
HV178_RS11860	COG1598	PFAM Uncharacterised protein family UPF0150
HV178_RS11865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV178_RS11870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV178_RS11875	COG3842	ATPase activity
HV178_RS11880	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV178_RS11885	COG1177	transmembrane transport
HV178_RS11895	COG2814	Major facilitator Superfamily
HV178_RS11900	COG2207	Transcriptional regulator
HV178_RS11930	COG0747	negative chemotaxis
HV178_RS11940	COG3238	Protein conserved in bacteria
HV178_RS11945	COG1247	-acetyltransferase
HV178_RS11955	COG2130	NADP-dependent
HV178_RS11975	COG0840	transmembrane signaling receptor activity
HV178_RS11980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV178_RS11985	COG1473	amidohydrolase
HV178_RS11990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV178_RS11995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV178_RS12010	COG1126	abc transporter atp-binding protein
HV178_RS12030	COG3321	synthase
HV178_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS12030	COG0604	alcohol dehydrogenase
HV178_RS12035	COG0583	DNA-binding transcription factor activity
HV178_RS12040	COG0625	glutathione transferase activity
HV178_RS12060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV178_RS12065	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV178_RS12080	COG0384	phenazine biosynthesis protein PhzF
HV178_RS12085	COG2181	nitrate reductase activity
HV178_RS12090	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV178_RS12095	COG1140	nitrate reductase beta subunit
HV178_RS12100	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV178_RS12105	COG2223	nitrite transmembrane transporter activity
HV178_RS12130	COG0697	spore germination
HV178_RS12140	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS12145	COG2864	formate dehydrogenase
HV178_RS12155	COG0488	(ABC) transporter
HV178_RS12175	COG1764	response to oxidative stress
HV178_RS12180	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS12185	COG2610	gluconate transmembrane transporter activity
HV178_RS12190	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV178_RS12200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV178_RS12205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV178_RS12215	COG4608	Belongs to the ABC transporter superfamily
HV178_RS12220	COG0444	Belongs to the ABC transporter superfamily
HV178_RS12225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV178_RS12230	COG0601	transmembrane transport
HV178_RS12235	COG0747	negative chemotaxis
HV178_RS12240	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV178_RS12255	COG0840	transmembrane signaling receptor activity
HV178_RS12280	COG4628	conserved protein (DUF2132)
HV178_RS12305	COG3121	Chaperone
HV178_RS12320	COG3121	Chaperone
HV178_RS12350	COG3781	membrane
HV178_RS12380	COG1012	belongs to the aldehyde dehydrogenase family
HV178_RS12385	COG0583	DNA-binding transcription factor activity
HV178_RS12400	COG1846	Transcriptional regulator
HV178_RS12420	COG2814	Major facilitator Superfamily
HV178_RS12425	COG0410	ABC transporter
HV178_RS12430	COG1129	ABC transporter
HV178_RS12455	COG3706	GGDEF domain
HV178_RS12470	COG4221	oxidoreductase activity
HV178_RS12475	COG1802	Transcriptional regulator
HV178_RS12485	COG0246	Mannitol dehydrogenase
HV178_RS12495	COG4948	Mandelate Racemase Muconate Lactonizing
HV178_RS12510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV178_RS12530	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS12535	COG3302	dmso reductase anchor subunit
HV178_RS12540	COG3381	protein complex oligomerization
HV178_RS12550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV178_RS12555	COG1940	carbohydrate kinase activity
HV178_RS12560	COG0583	DNA-binding transcription factor activity
HV178_RS12565	COG2814	Major facilitator Superfamily
HV178_RS12575	COG2205	protein histidine kinase activity
HV178_RS12580	COG0745	RESPONSE REGULATOR receiver
HV178_RS12595	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV178_RS12605	COG3591	Belongs to the peptidase S1B family
HV178_RS12620	COG0628	permease
HV178_RS12625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV178_RS12630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV178_RS12640	COG0531	amino acid
HV178_RS12650	COG3136	membrane protein required for alginate biosynthesis
HV178_RS12655	COG0745	RESPONSE REGULATOR receiver
HV178_RS12665	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV178_RS12675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV178_RS12685	COG2205	protein histidine kinase activity
HV178_RS12700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS12700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS12710	COG5339	Protein conserved in bacteria
HV178_RS12715	COG1609	Transcriptional regulator
HV178_RS12720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS12720	COG1263	PTS System
HV178_RS12725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV178_RS12735	COG0673	inositol 2-dehydrogenase activity
HV178_RS12785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV178_RS12795	COG0625	glutathione transferase activity
HV178_RS12800	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV178_RS12815	COG3895	Periplasmic Protein
HV178_RS12840	COG1566	PFAM secretion protein HlyD family protein
HV178_RS12855	COG4989	oxidoreductase activity
HV178_RS12860	COG3313	Fe-S protein
HV178_RS12865	COG1309	transcriptional regulator
HV178_RS12870	COG1902	pentaerythritol trinitrate reductase activity
HV178_RS12875	COG0346	lactoylglutathione lyase activity
HV178_RS12885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV178_RS12890	COG0791	NLP P60 protein
HV178_RS12895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV178_RS12900	COG2814	Major facilitator Superfamily
HV178_RS12915	COG0583	DNA-binding transcription factor activity
HV178_RS12920	COG2814	Major facilitator Superfamily
HV178_RS12925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV178_RS12930	COG0307	riboflavin synthase, alpha
HV178_RS12955	COG0251	oxidation-reduction process
HV178_RS12975	COG5001	Diguanylate cyclase
HV178_RS12975	COG3300	MHYT domain
HV178_RS12980	COG0386	Belongs to the glutathione peroxidase family
HV178_RS12985	COG0628	permease
HV178_RS13000	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS13005	COG2378	regulation of single-species biofilm formation
HV178_RS13025	COG3121	Chaperone
HV178_RS13030	COG3188	usher protein
HV178_RS13045	COG4977	sequence-specific DNA binding
HV178_RS13090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV178_RS13105	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV178_RS13115	COG1012	belongs to the aldehyde dehydrogenase family
HV178_RS13130	COG1113	amino acid transport
HV178_RS13140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV178_RS13150	COG0765	amino acid transport
HV178_RS13155	COG0765	amino acid transport
HV178_RS13165	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV178_RS13170	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS13180	COG2414	aldehyde ferredoxin oxidoreductase
HV178_RS13185	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS13235	COG1464	Belongs to the NlpA lipoprotein family
HV178_RS13240	COG2011	ABC-type metal ion transport system permease component
HV178_RS13250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS13260	COG2267	carboxylic ester hydrolase activity
HV178_RS13265	COG0531	amino acid
HV178_RS13285	COG1376	ErfK ybiS ycfS ynhG family protein
HV178_RS13300	COG0719	Fe-S assembly protein
HV178_RS13305	COG0396	ATPase activity
HV178_RS13310	COG0719	Fe-S assembly protein
HV178_RS13315	COG0316	Belongs to the HesB IscA family
HV178_RS13320	COG0583	DNA-binding transcription factor activity
HV178_RS13335	COG2050	protein possibly involved in aromatic compounds catabolism
HV178_RS13340	COG0247	lactate metabolic process
HV178_RS13340	COG0277	FAD linked oxidase domain protein
HV178_RS13345	COG0628	permease
HV178_RS13360	COG0738	Major facilitator superfamily
HV178_RS13365	COG2271	Major facilitator Superfamily
HV178_RS13380	COG4670	ketone body catabolic process
HV178_RS13385	COG1960	acyl-CoA dehydrogenase activity
HV178_RS13390	COG1917	Cupin 2, conserved barrel domain protein
HV178_RS13390	COG2207	Transcriptional regulator
HV178_RS13395	COG2086	electron transfer activity
HV178_RS13400	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV178_RS13405	COG0644	oxidoreductase
HV178_RS13410	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV178_RS13415	COG0318	PFAM AMP-dependent synthetase and ligase
HV178_RS13420	COG0574	Belongs to the PEP-utilizing enzyme family
HV178_RS13420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV178_RS13430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV178_RS13435	COG4256	Hemin uptake protein
HV178_RS13440	COG4771	TonB-dependent receptor
HV178_RS13445	COG3720	iron ion transport
HV178_RS13450	COG4558	Periplasmic binding protein
HV178_RS13455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS13475	COG0791	NLP P60 protein
HV178_RS13485	COG0386	Belongs to the glutathione peroxidase family
HV178_RS13520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV178_RS13540	COG3137	Salt-induced outer membrane protein
HV178_RS13545	COG1105	Belongs to the carbohydrate kinase PfkB family
HV178_RS13550	COG3001	Fructosamine kinase
HV178_RS13560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV178_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS13570	COG1988	membrane-bound metal-dependent
HV178_RS13585	COG0753	catalase activity
HV178_RS13595	COG1486	melibiose metabolic process
HV178_RS13600	COG2169	Transcriptional regulator
HV178_RS13600	COG1917	Cupin 2, conserved barrel domain protein
HV178_RS13605	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV178_RS13610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV178_RS13615	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV178_RS13620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV178_RS13630	COG0322	excinuclease ABC activity
HV178_RS13640	COG3678	ATP-independent chaperone mediated protein folding
HV178_RS13670	COG0708	Exodeoxyribonuclease III
HV178_RS13675	COG0398	Pfam SNARE associated Golgi protein
HV178_RS13680	COG0398	Pfam SNARE associated Golgi protein
HV178_RS13685	COG4134	Bacterial extracellular solute-binding protein
HV178_RS13690	COG4135	transport system, permease component
HV178_RS13695	COG4136	ATPase activity
HV178_RS13700	COG2897	thiosulfate sulfurtransferase activity
HV178_RS13705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV178_RS13710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV178_RS13715	COG0494	nUDIX hydrolase
HV178_RS13730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV178_RS13740	COG0778	Nitroreductase
HV178_RS13745	COG0616	signal peptide processing
HV178_RS13750	COG0252	asparaginase activity
HV178_RS13755	COG1335	isochorismatase
HV178_RS13760	COG2814	Major facilitator Superfamily
HV178_RS13765	COG1349	DNA-binding transcription factor activity
HV178_RS13770	COG0667	Aldo Keto reductase
HV178_RS13775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS13780	COG0191	fructose-bisphosphate aldolase activity
HV178_RS13785	COG1063	alcohol dehydrogenase
HV178_RS13790	COG2271	Major facilitator Superfamily
HV178_RS13795	COG1063	alcohol dehydrogenase
HV178_RS13810	COG3139	Protein of unknown function (DUF1315)
HV178_RS13830	COG0656	L-ascorbic acid biosynthetic process
HV178_RS13835	COG3713	MltA-interacting MipA family protein
HV178_RS13840	COG2766	serine protein kinase
HV178_RS13850	COG2226	methyltransferase
HV178_RS13855	COG2199	diguanylate cyclase activity
HV178_RS13860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV178_RS13870	COG2207	Transcriptional regulator
HV178_RS13875	COG2807	transmembrane transport
HV178_RS13880	COG0504	CTP synthase activity
HV178_RS13885	COG3189	MarR family transcriptional regulator
HV178_RS13890	COG3042	response to heat
HV178_RS13895	COG2203	Gaf domain
HV178_RS13895	COG2199	diguanylate cyclase activity
HV178_RS13910	COG2261	transglycosylase associated protein
HV178_RS13915	COG3383	formate dehydrogenase (NAD+) activity
HV178_RS13930	COG3615	Tellurite resistance protein tehB
HV178_RS13940	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV178_RS13945	COG1124	(ABC) transporter
HV178_RS13955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV178_RS13960	COG0601	transmembrane transport
HV178_RS13965	COG0747	negative chemotaxis
HV178_RS13970	COG4771	TonB-dependent receptor
HV178_RS14000	COG0538	isocitrate dehydrogenase activity
HV178_RS14020	COG0431	NADPH-dependent FMN reductase
HV178_RS14040	COG0538	isocitrate dehydrogenase activity
HV178_RS14050	COG2135	peptidase activity
HV178_RS14125	COG1196	nuclear chromosome segregation
HV178_RS14165	COG0740	serine-type endopeptidase activity
HV178_RS14210	COG3179	chitinase
HV178_RS14240	COG1403	HNH endonuclease
HV178_RS14245	COG3645	SOS response
HV178_RS14245	COG3646	Phage regulatory protein
HV178_RS14255	COG4725	Belongs to the MT-A70-like family
HV178_RS14260	COG1802	Transcriptional regulator
HV178_RS14260	COG4626	Terminase
HV178_RS14295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HV178_RS14320	COG0582	viral genome integration into host DNA
HV178_RS14330	COG0538	isocitrate dehydrogenase activity
HV178_RS14360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV178_RS14375	COG0500	methyltransferase
HV178_RS14420	COG0616	signal peptide processing
HV178_RS14435	COG1802	Transcriptional regulator
HV178_RS14435	COG4626	Terminase
HV178_RS14460	COG3179	chitinase
HV178_RS14490	COG0484	heat shock protein binding
HV178_RS14495	COG1403	HNH endonuclease
HV178_RS14500	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HV178_RS14515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HV178_RS14580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV178_RS14590	COG0582	viral genome integration into host DNA
HV178_RS14605	COG2850	peptidyl-arginine hydroxylation
HV178_RS14625	COG1177	transmembrane transport
HV178_RS14635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV178_RS14645	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV178_RS14650	COG1136	(ABC) transporter
HV178_RS14655	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV178_RS14660	COG4763	Acyl-transferase
HV178_RS14665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV178_RS14670	COG1388	LysM domain
HV178_RS14670	COG1376	ErfK ybiS ycfS ynhG family protein
HV178_RS14680	COG1309	transcriptional regulator
HV178_RS14690	COG3134	Outer membrane lipoprotein
HV178_RS14695	COG1252	NADH dehydrogenase
HV178_RS14720	COG5633	Lipoprotein
HV178_RS14725	COG0537	adenosine 5'-monophosphoramidase activity
HV178_RS14730	COG0583	DNA-binding transcription factor activity
HV178_RS14740	COG0309	Hydrogenase expression formation protein (HypE)
HV178_RS14745	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV178_RS14750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV178_RS14755	COG2223	nitrite transmembrane transporter activity
HV178_RS14765	COG0534	Mate efflux family protein
HV178_RS14775	COG0583	DNA-binding transcription factor activity
HV178_RS14795	COG1595	DNA-templated transcription, initiation
HV178_RS14800	COG3712	iron ion homeostasis
HV178_RS14805	COG4772	TonB-dependent receptor
HV178_RS14810	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV178_RS14815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS14820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS14825	COG1120	ATPase activity
HV178_RS14835	COG0406	alpha-ribazole phosphatase activity
HV178_RS14850	COG0477	Major facilitator Superfamily
HV178_RS14855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV178_RS14870	COG0084	hydrolase, TatD family'
HV178_RS14875	COG0470	DNA polymerase III
HV178_RS14885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV178_RS14890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV178_RS14895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV178_RS14930	COG1399	metal-binding, possibly nucleic acid-binding protein
HV178_RS14940	COG0564	pseudouridine synthase activity
HV178_RS14945	COG1530	ribonuclease E activity
HV178_RS14950	COG0583	DNA-binding transcription factor activity
HV178_RS14985	COG4786	Flagellar basal body rod
HV178_RS14990	COG4787	bacterial-type flagellum-dependent cell motility
HV178_RS15005	COG1558	bacterial-type flagellum-dependent cell motility
HV178_RS15045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV178_RS15085	COG3038	cytochrome b561
HV178_RS15100	COG1560	Kdo2-lipid A biosynthetic process
HV178_RS15110	COG2199	diguanylate cyclase activity
HV178_RS15120	COG5645	(Lipo)protein
HV178_RS15140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV178_RS15195	COG3381	protein complex oligomerization
HV178_RS15225	COG2962	Rard protein
HV178_RS15230	COG2990	Protein conserved in bacteria
HV178_RS15235	COG1702	phosphate starvation-inducible protein PhoH
HV178_RS15260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV178_RS15265	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV178_RS15265	COG0506	proline dehydrogenase activity
HV178_RS15265	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV178_RS15270	COG3755	Protein conserved in bacteria
HV178_RS15275	COG1309	transcriptional regulator
HV178_RS15285	COG3729	General stress protein
HV178_RS15305	COG0640	Transcriptional regulator
HV178_RS15325	COG1136	(ABC) transporter
HV178_RS15325	COG0577	efflux transmembrane transporter activity
HV178_RS15335	COG1136	(ABC) transporter
HV178_RS15335	COG0577	efflux transmembrane transporter activity
HV178_RS15350	COG0672	)-iron permease
HV178_RS15355	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV178_RS15360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV178_RS15365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV178_RS15365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV178_RS15415	COG0813	purine-nucleoside phosphorylase activity
HV178_RS15430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS15435	COG1120	ATPase activity
HV178_RS15445	COG0723	plastoquinol--plastocyanin reductase activity
HV178_RS15450	COG2857	Cytochrome c1
HV178_RS15450	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV178_RS15470	COG0670	Belongs to the BI1 family
HV178_RS15495	COG1832	CoA-binding protein
HV178_RS15510	COG0210	DNA helicase
HV178_RS15515	COG3304	Inner membrane component domain
HV178_RS15520	COG1289	transmembrane transporter activity
HV178_RS15525	COG3070	regulator of competence-specific genes
HV178_RS15545	COG1067	ATP-dependent peptidase activity
HV178_RS15555	COG3130	regulation of translation
HV178_RS15560	COG3009	Protein conserved in bacteria
HV178_RS15565	COG3008	intermembrane lipid transfer
HV178_RS15565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV178_RS15570	COG2995	paraquat-inducible protein a
HV178_RS15575	COG0488	(ABC) transporter
HV178_RS15585	COG3217	Mosc domain protein beta barrel domain protein
HV178_RS15585	COG0633	Ferredoxin
HV178_RS15600	COG0431	NADPH-dependent FMN reductase
HV178_RS15605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV178_RS15615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV178_RS15620	COG1116	anion transmembrane transporter activity
HV178_RS15625	COG0308	aminopeptidase N
HV178_RS15740	COG0740	serine-type endopeptidase activity
HV178_RS15745	COG4695	Portal protein
HV178_RS15750	COG4626	Terminase
HV178_RS15750	COG1802	Transcriptional regulator
HV178_RS15870	COG0582	viral genome integration into host DNA
HV178_RS15890	COG1448	Aminotransferase
HV178_RS15895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV178_RS15900	COG3108	Peptidase M15
HV178_RS15905	COG2989	Protein conserved in bacteria
HV178_RS15915	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV178_RS15925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV178_RS15930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV178_RS15935	COG3173	Aminoglycoside phosphotransferase
HV178_RS15950	COG3214	Protein conserved in bacteria
HV178_RS15965	COG2333	competence protein COMEC
HV178_RS15965	COG0658	competence protein
HV178_RS15970	COG0776	regulation of translation
HV178_RS15975	COG0539	negative regulation of cytoplasmic translation
HV178_RS15985	COG0501	Belongs to the peptidase M48B family
HV178_RS16000	COG2323	membrane
HV178_RS16005	COG1944	ATP diphosphatase activity
HV178_RS16010	COG2116	formate transmembrane transporter activity
HV178_RS16015	COG1882	Formate acetyltransferase
HV178_RS16020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV178_RS16025	COG0531	amino acid
HV178_RS16035	COG1335	isochorismatase
HV178_RS16040	COG3302	dmso reductase anchor subunit
HV178_RS16045	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS16060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV178_RS16070	COG1674	ftsk spoiiie
HV178_RS16070	COG1178	ABC-type Fe3 transport system permease component
HV178_RS16080	COG0492	ferredoxin-NADP+ reductase activity
HV178_RS16085	COG4988	ABC transporter
HV178_RS16090	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV178_RS16105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV178_RS16110	COG0583	DNA-binding transcription factor activity
HV178_RS16120	COG1335	isochorismatase
HV178_RS16150	COG1177	transmembrane transport
HV178_RS16155	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV178_RS16160	COG3842	ATPase activity
HV178_RS16165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV178_RS16220	COG0583	DNA-binding transcription factor activity
HV178_RS16225	COG3226	Transcriptional regulator
HV178_RS16230	COG0738	Major facilitator superfamily
HV178_RS16235	COG0561	phosphatase activity
HV178_RS16245	COG2814	Major facilitator Superfamily
HV178_RS16250	COG0671	phosphoesterase, PA-phosphatase related
HV178_RS16255	COG1349	DNA-binding transcription factor activity
HV178_RS16260	COG1686	Belongs to the peptidase S11 family
HV178_RS16265	COG0625	glutathione transferase activity
HV178_RS16270	COG2133	pyrroloquinoline quinone binding
HV178_RS16305	COG1446	asparaginase
HV178_RS16315	COG0303	'Molybdopterin
HV178_RS16320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV178_RS16325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV178_RS16330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV178_RS16335	COG1882	Formate acetyltransferase
HV178_RS16340	COG0561	phosphatase activity
HV178_RS16350	COG0488	(ABC) transporter
HV178_RS16355	COG1376	ErfK ybiS ycfS ynhG family protein
HV178_RS16360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV178_RS16375	COG2194	sulfuric ester hydrolase activity
HV178_RS16380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV178_RS16395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV178_RS16400	COG0765	amino acid transport
HV178_RS16405	COG1126	abc transporter atp-binding protein
HV178_RS16410	COG0668	transmembrane transport
HV178_RS16425	COG4774	siderophore transport
HV178_RS16435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV178_RS16445	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV178_RS16450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV178_RS16460	COG0471	metal ion transport
HV178_RS16470	COG2188	Transcriptional regulator
HV178_RS16475	COG0513	Belongs to the DEAD box helicase family
HV178_RS16480	COG1309	transcriptional regulator
HV178_RS16490	COG1131	(ABC) transporter
HV178_RS16495	COG0842	Transport permease protein
HV178_RS16500	COG0842	Transport permease protein
HV178_RS16510	COG3568	Endonuclease Exonuclease Phosphatase
HV178_RS16515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV178_RS16520	COG0392	lysyltransferase activity
HV178_RS16525	COG0670	Belongs to the BI1 family
HV178_RS16530	COG0314	molybdopterin synthase activity
HV178_RS16535	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV178_RS16545	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV178_RS16570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV178_RS16595	COG1881	PFAM PEBP family protein
HV178_RS16625	COG4677	pectinesterase activity
HV178_RS16635	COG0561	phosphatase activity
HV178_RS16645	COG4149	molybdate abc transporter
HV178_RS16650	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV178_RS16660	COG3585	molybdate ion transport
HV178_RS16660	COG2005	Transcriptional regulator
HV178_RS16665	COG1119	ATPase activity
HV178_RS16670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV178_RS16675	COG1085	galactose-1-phosphate uridylyltransferase
HV178_RS16685	COG2017	converts alpha-aldose to the beta-anomer
HV178_RS16695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV178_RS16705	COG1230	cation diffusion facilitator family transporter
HV178_RS16710	COG3201	nicotinamide mononucleotide transporter
HV178_RS16750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV178_RS16755	COG2885	chlorophyll binding
HV178_RS16765	COG3064	Membrane
HV178_RS16770	COG0848	biopolymer transport protein
HV178_RS16775	COG0811	peptide transport
HV178_RS16780	COG0824	Thioesterase
HV178_RS16785	COG3790	cyd operon protein YbgE
HV178_RS16790	COG4890	Cyd operon protein YbgT
HV178_RS16795	COG1294	oxidase, subunit
HV178_RS16800	COG1271	oxidase subunit
HV178_RS16805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV178_RS16815	COG4865	methylaspartate mutase activity
HV178_RS16820	COG3799	methylaspartate ammonia-lyase activity
HV178_RS16835	COG1301	dicarboxylic acid transport
HV178_RS16845	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS16845	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS16855	COG0583	DNA-binding transcription factor activity
HV178_RS16860	COG1648	precorrin-2 dehydrogenase activity
HV178_RS16860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV178_RS16870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV178_RS16880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV178_RS16885	COG0567	Dehydrogenase, E1 component
HV178_RS16890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV178_RS16895	COG1053	succinate dehydrogenase
HV178_RS16900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV178_RS16905	COG2009	succinate dehydrogenase
HV178_RS16915	COG3157	Type VI secretion system effector, Hcp
HV178_RS16930	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HV178_RS16935	COG3180	Ammonia monooxygenase
HV178_RS16965	COG1984	allophanate hydrolase subunit 2
HV178_RS16970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV178_RS16985	COG5464	transposase or invertase
HV178_RS16995	COG3272	Protein of unknown function (DUF1722)
HV178_RS17025	COG2205	protein histidine kinase activity
HV178_RS17030	COG0745	RESPONSE REGULATOR receiver
HV178_RS17035	COG0033	Phosphoglucomutase
HV178_RS17040	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV178_RS17045	COG0596	Alpha beta hydrolase
HV178_RS17055	COG0716	FMN binding
HV178_RS17065	COG0735	belongs to the Fur family
HV178_RS17070	COG0583	DNA-binding transcription factor activity
HV178_RS17075	COG1053	succinate dehydrogenase
HV178_RS17105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS17105	COG2190	(PTS) system
HV178_RS17105	COG1263	PTS System
HV178_RS17115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV178_RS17120	COG1940	carbohydrate kinase activity
HV178_RS17120	COG1846	Transcriptional regulator
HV178_RS17125	COG0647	UMP catabolic process
HV178_RS17130	COG0367	asparagine synthase
HV178_RS17170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV178_RS17180	COG1702	phosphate starvation-inducible protein PhoH
HV178_RS17190	COG4535	Mg2 and Co2 transporter CorC
HV178_RS17205	COG0765	amino acid transport
HV178_RS17210	COG0765	amino acid transport
HV178_RS17215	COG1126	abc transporter atp-binding protein
HV178_RS17225	COG2888	peptidyl-tyrosine sulfation
HV178_RS17240	COG1466	dna polymerase III delta subunit
HV178_RS17250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV178_RS17260	COG0799	negative regulation of ribosome biogenesis
HV178_RS17270	COG0768	penicillin binding
HV178_RS17275	COG0772	Belongs to the SEDS family
HV178_RS17280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV178_RS17285	COG1686	Belongs to the peptidase S11 family
HV178_RS17310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV178_RS17330	COG3069	C4-dicarboxylate transmembrane transporter activity
HV178_RS17335	COG4565	transcriptional regulatory protein
HV178_RS17340	COG3290	protein histidine kinase activity
HV178_RS17345	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV178_RS17355	COG2301	Belongs to the HpcH HpaI aldolase family
HV178_RS17360	COG3051	citrate lyase alpha subunit
HV178_RS17375	COG0471	metal ion transport
HV178_RS17380	COG3719	Belongs to the RNase T2 family
HV178_RS17395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV178_RS17415	COG0243	molybdopterin cofactor binding
HV178_RS17425	COG3634	alkyl hydroperoxide reductase activity
HV178_RS17435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV178_RS17440	COG0583	DNA-binding transcription factor activity
HV178_RS17445	COG3969	phosphoadenosine phosphosulfate
HV178_RS17450	COG1475	DNA binding
HV178_RS17455	COG0436	Aminotransferase
HV178_RS17460	COG0371	Dehydrogenase
HV178_RS17465	COG2879	small protein
HV178_RS17470	COG1966	Carbon starvation protein
HV178_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS17490	COG3433	isochorismatase activity
HV178_RS17490	COG1535	isochorismatase
HV178_RS17495	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV178_RS17500	COG1169	isochorismate synthase
HV178_RS17505	COG4592	Periplasmic binding protein
HV178_RS17515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS17520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS17525	COG1120	ATPase activity
HV178_RS17530	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV178_RS17535	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV178_RS17535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV178_RS17540	COG3251	PFAM MbtH domain protein
HV178_RS17545	COG2382	esterase
HV178_RS17550	COG4771	TonB-dependent receptor
HV178_RS17590	COG2315	Protein conserved in bacteria
HV178_RS17600	COG0668	transmembrane transport
HV178_RS17620	COG2211	Major facilitator Superfamily
HV178_RS17625	COG1113	amino acid transport
HV178_RS17650	COG5001	Diguanylate cyclase
HV178_RS17650	COG3300	MHYT domain
HV178_RS17665	COG3059	membrane
HV178_RS17675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV178_RS17680	COG2207	Transcriptional regulator
HV178_RS17685	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV178_RS17690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS17695	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS17700	COG1538	Outer membrane efflux protein
HV178_RS17705	COG0745	RESPONSE REGULATOR receiver
HV178_RS17710	COG5002	protein histidine kinase activity
HV178_RS17725	COG0321	lipoyl(octanoyl) transferase activity
HV178_RS17725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV178_RS17730	COG0243	molybdopterin cofactor binding
HV178_RS17740	COG2026	Addiction module toxin, RelE StbE family
HV178_RS17745	COG3077	Addiction module antitoxin, RelB DinJ family
HV178_RS17750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HV178_RS17760	COG2801	Transposase and inactivated derivatives
HV178_RS17785	COG3005	denitrification pathway
HV178_RS17790	COG0745	RESPONSE REGULATOR receiver
HV178_RS17795	COG1879	ABC-type sugar transport system periplasmic component
HV178_RS17810	COG3423	Transcriptional regulator
HV178_RS17815	COG2801	Transposase and inactivated derivatives
HV178_RS17820	COG2842	Transposition protein
HV178_RS17840	COG4396	Host-nuclease inhibitor protein Gam
HV178_RS17855	COG5566	PFAM Mor transcription activator
HV178_RS17915	COG4373	Mu-like prophage FluMu protein gp28
HV178_RS17935	COG4397	Mu-like prophage major head subunit gpT
HV178_RS17965	COG4386	tail sheath protein
HV178_RS17975	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
HV178_RS18005	COG3299	homolog of phage Mu protein gp47
HV178_RS18010	COG3778	Protein conserved in bacteria
HV178_RS18035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV178_RS18095	COG3539	Fimbrial protein
HV178_RS18105	COG2501	S4 domain
HV178_RS18110	COG1988	membrane-bound metal-dependent
HV178_RS18120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV178_RS18130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV178_RS18135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV178_RS18155	COG1464	Belongs to the NlpA lipoprotein family
HV178_RS18160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV178_RS18165	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV178_RS18170	COG4181	ATPase activity
HV178_RS18175	COG2755	lipolytic protein G-D-S-L family
HV178_RS18180	COG0300	oxidoreductase activity
HV178_RS18185	COG3118	belongs to the thioredoxin family
HV178_RS18190	COG0390	transport system, permease component
HV178_RS18195	COG4619	ABC transporter
HV178_RS18200	COG0330	HflC and HflK could
HV178_RS18205	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV178_RS18225	COG4771	TonB-dependent receptor
HV178_RS18230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV178_RS18240	COG3721	Heme iron utilization protein
HV178_RS18250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS18265	COG3735	TraB family
HV178_RS18270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV178_RS18280	COG2223	nitrite transmembrane transporter activity
HV178_RS18285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV178_RS18285	COG4651	solute:proton antiporter activity
HV178_RS18290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS18335	COG2832	Protein of unknown function (DUF454)
HV178_RS18340	COG3923	Primosomal replication protein n
HV178_RS18350	COG3264	Mechanosensitive ion channel
HV178_RS18350	COG1196	nuclear chromosome segregation
HV178_RS18355	COG1309	transcriptional regulator
HV178_RS18360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS18365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV178_RS18380	COG0110	maltose O-acetyltransferase activity
HV178_RS18400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV178_RS18405	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV178_RS18410	COG2364	Membrane
HV178_RS18415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV178_RS18435	COG3695	enzyme binding
HV178_RS18440	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV178_RS18445	COG1946	Acyl-CoA thioesterase
HV178_RS18450	COG0004	ammonium transporteR
HV178_RS18455	COG0347	Belongs to the P(II) protein family
HV178_RS18460	COG1132	(ABC) transporter
HV178_RS18465	COG1132	(ABC) transporter
HV178_RS18470	COG1522	sequence-specific DNA binding
HV178_RS18485	COG4533	DNA binding
HV178_RS18495	COG0824	Thioesterase
HV178_RS18500	COG1555	photosystem II stabilization
HV178_RS18505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV178_RS18510	COG0776	regulation of translation
HV178_RS18515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV178_RS18535	COG0271	Belongs to the BolA IbaG family
HV178_RS18540	COG3056	Lipoprotein
HV178_RS18545	COG2223	nitrite transmembrane transporter activity
HV178_RS18550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV178_RS18555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV178_RS18560	COG1845	cytochrome c oxidase, subunit III
HV178_RS18565	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV178_RS18575	COG2814	Major facilitator Superfamily
HV178_RS18610	COG0142	geranyltranstransferase activity
HV178_RS18620	COG0667	Aldo Keto reductase
HV178_RS18625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV178_RS18630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV178_RS18645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV178_RS18645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV178_RS18655	COG4238	major outer membrane lipoprotein
HV178_RS18675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV178_RS18680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV178_RS18685	COG1862	Preprotein translocase
HV178_RS18695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV178_RS18705	COG0450	alkyl hydroperoxide reductase
HV178_RS18720	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV178_RS18730	COG1335	isochorismatase
HV178_RS18735	COG0583	DNA-binding transcription factor activity
HV178_RS18740	COG0366	Alpha amylase catalytic
HV178_RS18755	COG5002	protein histidine kinase activity
HV178_RS18765	COG0420	3'-5' exonuclease activity
HV178_RS18770	COG0419	ATPase involved in DNA repair
HV178_RS18775	COG2814	Major facilitator Superfamily
HV178_RS18780	COG1940	carbohydrate kinase activity
HV178_RS18795	COG4126	flavin adenine dinucleotide binding
HV178_RS18815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV178_RS18820	COG3706	GGDEF domain
HV178_RS18830	COG1785	Belongs to the alkaline phosphatase family
HV178_RS18845	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV178_RS18865	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV178_RS18870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV178_RS18875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV178_RS18885	COG0113	porphobilinogen synthase activity
HV178_RS18890	COG2175	clavaminate synthase activity
HV178_RS18895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV178_RS18900	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV178_RS18905	COG4521	taurine ABC transporter
HV178_RS18920	COG2271	Major facilitator Superfamily
HV178_RS18925	COG1840	ABC-type Fe3 transport system, periplasmic component
HV178_RS18935	COG3842	ATPase activity
HV178_RS18940	COG2040	homocysteine
HV178_RS18945	COG0833	amino acid
HV178_RS18950	COG2814	Major facilitator Superfamily
HV178_RS18985	COG1414	Transcriptional regulator
HV178_RS19015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV178_RS19030	COG1609	Transcriptional regulator
HV178_RS19055	COG2079	MmgE PrpD family protein
HV178_RS19060	COG0372	Belongs to the citrate synthase family
HV178_RS19070	COG3829	transcription factor binding
HV178_RS19080	COG1280	lysine exporter protein (LysE YggA)
HV178_RS19085	COG3706	GGDEF domain
HV178_RS19090	COG0348	domain, Protein
HV178_RS19095	COG1737	Transcriptional regulator
HV178_RS19105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS19110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV178_RS19115	COG1120	ATPase activity
HV178_RS19120	COG4774	siderophore transport
HV178_RS19140	COG0583	DNA-binding transcription factor activity
HV178_RS19160	COG3069	C4-dicarboxylate transmembrane transporter activity
HV178_RS19165	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV178_RS19175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV178_RS19180	COG0693	protein deglycase activity
HV178_RS19195	COG3039	Transposase
HV178_RS19210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV178_RS19215	COG0531	amino acid
HV178_RS19220	COG0174	glutamine synthetase
HV178_RS19225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV178_RS19230	COG1396	sequence-specific DNA binding
HV178_RS19230	COG1917	Cupin 2, conserved barrel domain protein
HV178_RS19235	COG1012	belongs to the aldehyde dehydrogenase family
HV178_RS19240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV178_RS19255	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HV178_RS19260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV178_RS19265	COG1999	signal sequence binding
HV178_RS19270	COG1773	rubredoxin
HV178_RS19275	COG1271	oxidase subunit
HV178_RS19280	COG1294	oxidase, subunit
HV178_RS19305	COG1609	Transcriptional regulator
HV178_RS19310	COG1757	Na H antiporter
HV178_RS19315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV178_RS19335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV178_RS19375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV178_RS19385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV178_RS19410	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV178_RS19435	COG0791	NLP P60 protein
HV178_RS19440	COG3034	peptidoglycan biosynthetic process
HV178_RS19445	COG0121	glutamine amidotransferase
HV178_RS19455	COG1960	acyl-CoA dehydrogenase activity
HV178_RS19460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV178_RS19470	COG2200	EAL domain
HV178_RS19485	COG3539	Fimbrial protein
HV178_RS19495	COG3121	Chaperone
HV178_RS19500	COG3188	usher protein
HV178_RS19510	COG3539	Fimbrial protein
HV178_RS19515	COG3039	Transposase
HV178_RS19525	COG0745	RESPONSE REGULATOR receiver
HV178_RS19540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV178_RS19550	COG2226	methyltransferase
HV178_RS19560	COG1388	LysM domain
HV178_RS19560	COG0741	lytic transglycosylase activity
HV178_RS19565	COG2226	methyltransferase
HV178_RS19575	COG2814	Major facilitator Superfamily
HV178_RS19580	COG0583	DNA-binding transcription factor activity
HV178_RS19615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV178_RS19625	COG2011	ABC-type metal ion transport system permease component
HV178_RS19630	COG1464	Belongs to the NlpA lipoprotein family
HV178_RS19640	COG1720	tRNA m6t6A37 methyltransferase activity
HV178_RS19650	COG3015	lipoprotein NlpE involved in copper resistance
HV178_RS19655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV178_RS19670	COG4568	rho-dependent transcription termination
HV178_RS19680	COG0346	lactoylglutathione lyase activity
HV178_RS19720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV178_RS19725	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV178_RS19740	COG0575	Belongs to the CDS family
HV178_RS19750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV178_RS19795	COG3835	regulator
HV178_RS19820	COG2860	membrane
HV178_RS19845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV178_RS19850	COG1120	ATPase activity
HV178_RS19855	COG4774	siderophore transport
HV178_RS19860	COG3539	Fimbrial protein
HV178_RS19865	COG3188	usher protein
HV178_RS19870	COG3121	Chaperone
HV178_RS19880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV178_RS19885	COG1643	Atp-dependent helicase
HV178_RS19890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV178_RS19910	COG0617	tRNA 3'-terminal CCA addition
HV178_RS19915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV178_RS19920	COG3539	Fimbrial protein
HV178_RS19925	COG3121	Chaperone
HV178_RS19930	COG3188	usher protein
HV178_RS19945	COG3539	Fimbrial protein
HV178_RS19975	COG3121	Chaperone
HV178_RS19980	COG3188	usher protein
HV178_RS20000	COG0726	polysaccharide deacetylase
HV178_RS20005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS20010	COG0842	Transport permease protein
HV178_RS20015	COG1131	(ABC) transporter
HV178_RS20020	COG0288	reversible hydration of carbon dioxide
HV178_RS20025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV178_RS20055	COG3064	Membrane
HV178_RS20070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV178_RS20075	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV178_RS20080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV178_RS20095	COG2211	Major facilitator Superfamily
HV178_RS20100	COG3940	Belongs to the glycosyl hydrolase 43 family
HV178_RS20105	COG3725	Membrane protein required for beta-lactamase induction
HV178_RS20120	COG4969	Belongs to the N-Me-Phe pilin family
HV178_RS20125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV178_RS20130	COG1459	type II secretion system
HV178_RS20140	COG0237	dephospho-CoA kinase activity
HV178_RS20155	COG0494	nUDIX hydrolase
HV178_RS20175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV178_RS20180	COG0849	cell division
HV178_RS20190	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV178_RS20205	COG0772	Belongs to the SEDS family
HV178_RS20210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV178_RS20220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV178_RS20225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV178_RS20230	COG0768	penicillin binding
HV178_RS20260	COG0028	Belongs to the TPP enzyme family
HV178_RS20295	COG1609	Transcriptional regulator
HV178_RS20305	COG1028	Short-chain dehydrogenase reductase Sdr
HV178_RS20310	COG2814	Major facilitator Superfamily
HV178_RS20340	COG0586	Pfam SNARE associated Golgi protein
HV178_RS20375	COG0235	Class ii aldolase
HV178_RS20385	COG0417	DNA replication proofreading
HV178_RS20395	COG0564	pseudouridine synthase activity
HV178_RS20405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV178_RS20455	COG2271	Major facilitator Superfamily
HV178_RS20465	COG0644	oxidoreductase
HV178_RS20520	COG0505	Belongs to the CarA family
HV178_RS20530	COG1609	Transcriptional regulator
HV178_RS20545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS20545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS20550	COG3715	PTS system
HV178_RS20555	COG3716	PTS system mannose fructose sorbose family IID component
HV178_RS20565	COG2140	Oxalate decarboxylase
HV178_RS20580	COG1047	Peptidyl-prolyl cis-trans
HV178_RS20595	COG0196	riboflavin kinase activity
HV178_RS20615	COG0583	DNA-binding transcription factor activity
HV178_RS20630	COG0443	Heat shock 70 kDa protein
HV178_RS20640	COG4735	regulation of single-species biofilm formation
HV178_RS20645	COG1584	GPR1 FUN34 yaaH family protein
HV178_RS20650	COG0477	Major facilitator Superfamily
HV178_RS20655	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV178_RS20665	COG1115	amino acid carrier protein
HV178_RS20675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV178_RS20685	COG0527	aspartate kinase activity
HV178_RS20685	COG0460	homoserine dehydrogenase
HV178_RS20695	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV178_RS20705	COG0745	RESPONSE REGULATOR receiver
HV178_RS20710	COG4452	Inner membrane protein CreD
HV178_RS20715	COG2205	protein histidine kinase activity
HV178_RS20720	COG0745	RESPONSE REGULATOR receiver
HV178_RS20725	COG3045	CreA protein
HV178_RS20730	COG2207	Transcriptional regulator
HV178_RS20730	COG3708	Transcriptional regulator
HV178_RS20750	COG0741	lytic transglycosylase activity
HV178_RS20755	COG0488	(ABC) transporter
HV178_RS20770	COG0560	Phosphoserine phosphatase
HV178_RS20775	COG3726	membrane protein affecting hemolysin expression
HV178_RS20805	COG1328	CTP reductase activity
HV178_RS20810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV178_RS20815	COG0084	hydrolase, TatD family'
HV178_RS20820	COG4667	esterase of the alpha-beta hydrolase superfamily
HV178_RS20825	COG5487	UPF0391 membrane protein
HV178_RS20830	COG2823	Periplasmic or secreted lipoprotein
HV178_RS20840	COG1011	Hydrolase
HV178_RS20845	COG0456	acetyltransferase
HV178_RS20850	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV178_RS20880	COG3706	GGDEF domain
HV178_RS20885	COG4114	ferric iron reductase
HV178_RS20890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV178_RS20900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV178_RS20905	COG2197	response regulator
HV178_RS20910	COG2197	response regulator
HV178_RS20915	COG2966	Psort location CytoplasmicMembrane, score
HV178_RS20930	COG1484	DNA-dependent DNA replication
HV178_RS20950	COG1063	alcohol dehydrogenase
HV178_RS20955	COG1802	Transcriptional regulator
HV178_RS20960	COG2271	Major facilitator Superfamily
HV178_RS20970	COG0840	transmembrane signaling receptor activity
HV178_RS20980	COG1966	Carbon starvation protein
HV178_RS20985	COG2879	small protein
HV178_RS20990	COG0523	cobalamin synthesis protein
HV178_RS21000	COG1566	PFAM secretion protein HlyD family protein
HV178_RS21010	COG5457	Domain of unknown function (DUF1127)
HV178_RS21015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV178_RS21020	COG5464	transposase or invertase
HV178_RS21040	COG0626	cystathionine gamma-synthase activity
HV178_RS21045	COG1301	dicarboxylic acid transport
HV178_RS21050	COG0583	DNA-binding transcription factor activity
HV178_RS21055	COG2733	membrane
HV178_RS21065	COG0477	Major facilitator Superfamily
HV178_RS21075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV178_RS21085	COG2186	Transcriptional regulator
HV178_RS21090	COG0246	Mannitol dehydrogenase
HV178_RS21100	COG2610	gluconate transmembrane transporter activity
HV178_RS21105	COG1556	Lactate utilization protein
HV178_RS21110	COG1139	Iron-sulfur cluster binding protein
HV178_RS21115	COG0247	lactate metabolic process
HV178_RS21120	COG1620	l-lactate permease
HV178_RS21265	COG0582	viral genome integration into host DNA
HV178_RS21370	COG1064	alcohol dehydrogenase
HV178_RS21375	COG0433	COG0433 Predicted ATPase
HV178_RS21380	COG0795	lipopolysaccharide-transporting ATPase activity
HV178_RS21385	COG0795	lipopolysaccharide-transporting ATPase activity
HV178_RS21395	COG2927	DNA polymerase III (CHI subunit)
HV178_RS21430	COG2731	YhcH YjgK YiaL family protein
HV178_RS21435	COG2235	arginine
HV178_RS21445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV178_RS21450	COG1288	antiporter activity
HV178_RS21455	COG1438	arginine binding
HV178_RS21500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV178_RS21515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV178_RS21515	COG1263	PTS System
HV178_RS21520	COG0366	Alpha amylase catalytic
HV178_RS21530	COG1737	Transcriptional regulator
HV178_RS21535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS21540	COG0383	alpha-mannosidase activity
HV178_RS21545	COG0366	Alpha amylase catalytic
HV178_RS21550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS21550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS21550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS21565	COG2026	Addiction module toxin, RelE StbE family
HV178_RS21570	COG3077	Addiction module antitoxin, RelB DinJ family
HV178_RS21575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS21575	COG3711	transcriptional antiterminator
HV178_RS21590	COG3964	amidohydrolase
HV178_RS21625	COG0312	modulator of DNA gyrase
HV178_RS21640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV178_RS21650	COG0840	transmembrane signaling receptor activity
HV178_RS21655	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS21660	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS21665	COG1129	ABC transporter
HV178_RS21670	COG1879	ABC-type sugar transport system periplasmic component
HV178_RS21680	COG2105	PFAM AIG2 family protein
HV178_RS21685	COG2911	Protein conserved in bacteria
HV178_RS21690	COG0729	surface antigen
HV178_RS21700	COG1609	Transcriptional regulator
HV178_RS21705	COG0673	inositol 2-dehydrogenase activity
HV178_RS21710	COG0673	inositol 2-dehydrogenase activity
HV178_RS21725	COG2211	Major facilitator Superfamily
HV178_RS21735	COG1253	flavin adenine dinucleotide binding
HV178_RS21745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV178_RS21750	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV178_RS21760	COG1733	regulation of RNA biosynthetic process
HV178_RS21765	COG0702	epimerase
HV178_RS21775	COG0697	spore germination
HV178_RS21780	COG0840	transmembrane signaling receptor activity
HV178_RS21790	COG1113	amino acid transport
HV178_RS21795	COG0545	Peptidyl-prolyl cis-trans isomerase
HV178_RS21800	COG3061	Opacity-associated protein A
HV178_RS21815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV178_RS21830	COG0730	response to heat
HV178_RS21880	COG1073	alpha beta
HV178_RS21885	COG3650	response to hydrogen peroxide
HV178_RS21895	COG1960	acyl-CoA dehydrogenase activity
HV178_RS21900	COG0754	glutathionylspermidine amidase activity
HV178_RS21905	COG5463	Belongs to the UPF0441 family
HV178_RS21910	COG3766	membrane
HV178_RS21920	COG1842	Phage shock protein A
HV178_RS21925	COG3789	protein conserved in bacteria
HV178_RS21930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV178_RS21935	COG0557	exoribonuclease II activity
HV178_RS21950	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV178_RS21955	COG0330	HflC and HflK could
HV178_RS21960	COG0330	HflC and HflK could
HV178_RS21965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV178_RS21970	COG1923	regulation of RNA biosynthetic process
HV178_RS21985	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV178_RS21990	COG0802	atpase or kinase
HV178_RS21995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV178_RS21995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV178_RS22000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV178_RS22035	COG1511	domain protein
HV178_RS22035	COG3264	Mechanosensitive ion channel
HV178_RS22050	COG1053	succinate dehydrogenase
HV178_RS22055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV178_RS22110	COG1509	lysine 2,3-aminomutase activity
HV178_RS22135	COG0531	amino acid
HV178_RS22140	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV178_RS22145	COG1027	Aspartate ammonia-lyase
HV178_RS22150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV178_RS22165	COG1309	transcriptional regulator
HV178_RS22175	COG0318	PFAM AMP-dependent synthetase and ligase
HV178_RS22205	COG3290	protein histidine kinase activity
HV178_RS22210	COG4565	transcriptional regulatory protein
HV178_RS22215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV178_RS22220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS22220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV178_RS22225	COG3647	Membrane
HV178_RS22235	COG2211	Major facilitator Superfamily
HV178_RS22240	COG1486	melibiose metabolic process
HV178_RS22245	COG2169	Transcriptional regulator
HV178_RS22250	COG1982	Orn Lys Arg decarboxylase major
HV178_RS22255	COG2207	Transcriptional regulator
HV178_RS22260	COG0531	amino acid
HV178_RS22300	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV178_RS22305	COG2824	Alkylphosphonate utilization operon protein PhnA
HV178_RS22310	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV178_RS22315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV178_RS22320	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV178_RS22325	COG3639	organic phosphonate transmembrane transporter activity
HV178_RS22330	COG2188	Transcriptional regulator
HV178_RS22335	COG3624	Phosphonate C-P lyase system protein PhnG
HV178_RS22340	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV178_RS22345	COG3626	phosphonate metabolism
HV178_RS22350	COG3627	carbon phosphorus lyase activity
HV178_RS22355	COG4107	phosphonate C-P lyase system protein PhnK
HV178_RS22360	COG4778	phosphonate C-P lyase system protein PhnL
HV178_RS22365	COG3454	Phosphonate metabolism
HV178_RS22375	COG0456	acetyltransferase
HV178_RS22380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV178_RS22395	COG1129	ABC transporter
HV178_RS22400	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS22425	COG0745	RESPONSE REGULATOR receiver
HV178_RS22430	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV178_RS22440	COG1566	PFAM secretion protein HlyD family protein
HV178_RS22445	COG1289	transmembrane transporter activity
HV178_RS22450	COG1538	Outer membrane efflux protein
HV178_RS22460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV178_RS22465	COG1301	dicarboxylic acid transport
HV178_RS22470	COG4235	cytochrome complex assembly
HV178_RS22475	COG3088	subunit of a heme lyase
HV178_RS22480	COG1138	Cytochrome C-type biogenesis protein
HV178_RS22485	COG3301	Polysulphide reductase, NrfD
HV178_RS22490	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS22495	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV178_RS22510	COG3162	membrane
HV178_RS22520	COG1346	cytolysis
HV178_RS22525	COG1380	Effector of murein hydrolase LrgA
HV178_RS22530	COG0583	DNA-binding transcription factor activity
HV178_RS22535	COG0025	NhaP-type Na H and K H
HV178_RS22540	COG2252	PERMEase
HV178_RS22545	COG0789	Transcriptional regulator
HV178_RS22555	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV178_RS22570	COG0629	single-stranded DNA binding
HV178_RS22575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV178_RS22580	COG2315	Protein conserved in bacteria
HV178_RS22585	COG3700	Belongs to the class B bacterial acid phosphatase family
HV178_RS22590	COG1448	Aminotransferase
HV178_RS22600	COG0305	Participates in initiation and elongation during chromosome replication
HV178_RS22615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV178_RS22625	COG0735	belongs to the Fur family
HV178_RS22630	COG3237	CsbD-like
HV178_RS22635	COG0534	Mate efflux family protein
HV178_RS22645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV178_RS22690	COG2182	Extracellular solute-binding protein
HV178_RS22705	COG2814	Major facilitator Superfamily
HV178_RS22705	COG0477	Major facilitator Superfamily
HV178_RS22710	COG3223	Belongs to the PsiE family
HV178_RS22715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV178_RS22720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV178_RS22745	COG0527	aspartate kinase activity
HV178_RS22750	COG3541	Predicted nucleotidyltransferase
HV178_RS22760	COG4650	regulator
HV178_RS22780	COG0561	phosphatase activity
HV178_RS22795	COG1187	pseudouridine synthase activity
HV178_RS22835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV178_RS22845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV178_RS22860	COG0745	RESPONSE REGULATOR receiver
HV178_RS22865	COG3850	Histidine kinase
HV178_RS22865	COG5002	protein histidine kinase activity
HV178_RS22885	COG0646	methionine synthase
HV178_RS22885	COG1410	methionine synthase
HV178_RS22895	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV178_RS22905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV178_RS22915	COG0456	acetyltransferase
HV178_RS22940	COG0151	Belongs to the GarS family
HV178_RS22950	COG4191	Histidine kinase
HV178_RS23010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV178_RS23015	COG2104	thiamine diphosphate biosynthetic process
HV178_RS23030	COG1278	Cold shock
HV178_RS23040	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV178_RS23075	COG0250	Participates in transcription elongation, termination and antitermination
HV178_RS23120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV178_RS23180	COG0583	DNA-binding transcription factor activity
HV178_RS23215	COG2207	Transcriptional regulator
HV178_RS23225	COG0371	Dehydrogenase
HV178_RS23230	COG1349	DNA-binding transcription factor activity
HV178_RS23235	COG1882	Formate acetyltransferase
HV178_RS23245	COG0363	glucosamine-6-phosphate deaminase activity
HV178_RS23250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV178_RS23265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV178_RS23270	COG0583	DNA-binding transcription factor activity
HV178_RS23280	COG0737	Belongs to the 5'-nucleotidase family
HV178_RS23290	COG0460	homoserine dehydrogenase
HV178_RS23290	COG0527	aspartate kinase activity
HV178_RS23295	COG0626	cystathionine gamma-synthase activity
HV178_RS23305	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HV178_RS23315	COG2211	Major facilitator Superfamily
HV178_RS23330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV178_RS23335	COG1609	Transcriptional regulator
HV178_RS23340	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV178_RS23355	COG1575	Belongs to the MenA family. Type 1 subfamily
HV178_RS23370	COG3074	FtsZ-dependent cytokinesis
HV178_RS23375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV178_RS23385	COG1494	fructose-1,6-bisphosphatase
HV178_RS23395	COG3152	Membrane
HV178_RS23410	COG0471	metal ion transport
HV178_RS23420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV178_RS23445	COG3778	Protein conserved in bacteria
HV178_RS23450	COG3299	homolog of phage Mu protein gp47
HV178_RS23480	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
HV178_RS23490	COG4386	tail sheath protein
HV178_RS23520	COG4397	Mu-like prophage major head subunit gpT
HV178_RS23540	COG4373	Mu-like prophage FluMu protein gp28
HV178_RS23600	COG5566	PFAM Mor transcription activator
HV178_RS23615	COG4396	Host-nuclease inhibitor protein Gam
HV178_RS23635	COG2842	Transposition protein
HV178_RS23640	COG2801	Transposase and inactivated derivatives
HV178_RS23680	COG3678	ATP-independent chaperone mediated protein folding
HV178_RS23685	COG0745	RESPONSE REGULATOR receiver
HV178_RS23690	COG2205	protein histidine kinase activity
HV178_RS23695	COG2258	MOSC domain
HV178_RS23700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV178_RS23745	COG1454	alcohol dehydrogenase
HV178_RS23760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV178_RS23770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS23775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS23775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV178_RS23780	COG1363	Peptidase, m42
HV178_RS23785	COG3711	transcriptional antiterminator
HV178_RS23785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV178_RS23815	COG0437	4 iron, 4 sulfur cluster binding
HV178_RS23820	COG2864	formate dehydrogenase
HV178_RS23835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV178_RS23845	COG0456	acetyltransferase
HV178_RS23850	COG1490	D-aminoacyl-tRNA deacylase activity
HV178_RS23860	COG1011	Hydrolase
HV178_RS23865	COG1349	DNA-binding transcription factor activity
HV178_RS23870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS23880	COG3684	Belongs to the aldolase LacD family
HV178_RS23890	COG2017	converts alpha-aldose to the beta-anomer
HV178_RS23895	COG1501	Belongs to the glycosyl hydrolase 31 family
HV178_RS23925	COG3852	Histidine kinase
HV178_RS23930	COG2204	response regulator
HV178_RS23940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV178_RS23960	COG0204	Acyl-transferase
HV178_RS23975	COG3084	Protein conserved in bacteria
HV178_RS23980	COG0746	molybdenum cofactor guanylyltransferase activity
HV178_RS23985	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV178_RS24025	COG1739	Uncharacterized protein family UPF0029
HV178_RS24045	COG1609	Transcriptional regulator
HV178_RS24050	COG1940	carbohydrate kinase activity
HV178_RS24075	COG0805	protein transport
HV178_RS24135	COG0583	DNA-binding transcription factor activity
HV178_RS24140	COG0697	spore germination
HV178_RS24145	COG0561	phosphatase activity
HV178_RS24150	COG2267	carboxylic ester hydrolase activity
HV178_RS24155	COG1280	lysine exporter protein (LysE YggA)
HV178_RS24160	COG1280	lysine exporter protein (LysE YggA)
HV178_RS24195	COG1011	Hydrolase
HV178_RS24245	COG2959	enzyme of heme biosynthesis
HV178_RS24250	COG3071	HemY protein
HV178_RS24295	COG2244	polysaccharide biosynthetic process
HV178_RS24300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV178_RS24305	COG0456	acetyltransferase
HV178_RS24310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV178_RS24315	COG1088	dTDP-glucose 4,6-dehydratase activity
HV178_RS24320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV178_RS24335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV178_RS24340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV178_RS24350	COG3118	belongs to the thioredoxin family
HV178_RS24370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV178_RS24390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV178_RS24400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV178_RS24405	COG3978	acetolactate synthase activity
HV178_RS24425	COG3085	chromosome segregation
HV178_RS24465	COG2186	Transcriptional regulator
HV178_RS24470	COG0477	Major facilitator Superfamily
HV178_RS24475	COG1609	Transcriptional regulator
HV178_RS24480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV178_RS24485	COG1879	ABC-type sugar transport system periplasmic component
HV178_RS24490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS24500	COG1869	D-ribose catabolic process
HV178_RS24525	COG1522	sequence-specific DNA binding
HV178_RS24530	COG0716	FMN binding
HV178_RS24545	COG3312	ion transport
HV178_RS24570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV178_RS24580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV178_RS24585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV178_RS24605	COG3121	Chaperone
HV178_RS24615	COG3539	Fimbrial protein
HV178_RS24620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV178_RS24625	COG0573	inorganic phosphate transmembrane transporter activity
HV178_RS24630	COG0581	inorganic phosphate transmembrane transporter activity
HV178_RS24640	COG0704	Plays a role in the regulation of phosphate uptake
HV178_RS24645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV178_RS24650	COG2252	PERMEase
HV178_RS24655	COG0431	NADPH-dependent FMN reductase
HV178_RS24660	COG2091	lysine biosynthetic process via aminoadipic acid
HV178_RS24695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV178_RS24770	COG1216	Glycosyl transferase, family 2
HV178_RS24770	COG1442	glycosyl transferase family 8
HV178_RS24775	COG0589	response to stress
HV178_RS24780	COG0659	secondary active sulfate transmembrane transporter activity
HV178_RS24825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV178_RS24890	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV178_RS24920	COG0739	heme binding
HV178_RS24930	COG2132	Multicopper oxidase
HV178_RS24935	COG3667	copper resistance
HV178_RS24940	COG2372	response to copper ion
HV178_RS24945	COG1276	copper resistance
HV178_RS24950	COG0745	RESPONSE REGULATOR receiver
HV178_RS24955	COG2205	protein histidine kinase activity
HV178_RS24980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV178_RS24995	COG4372	Transposase
HV178_RS25000	COG3436	PFAM IS66 Orf2 family protein
HV178_RS25025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV178_RS25030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV178_RS25045	COG3423	Transcriptional regulator
HV178_RS25190	COG0592	DNA-directed DNA polymerase activity
HV178_RS25210	COG3039	Transposase
HV178_RS25215	COG1802	Transcriptional regulator
HV178_RS25295	COG0038	chloride channel
HV178_RS25300	COG0671	phosphoesterase, PA-phosphatase related
HV178_RS25305	COG1227	inorganic diphosphatase activity
HV178_RS25315	COG0148	phosphopyruvate hydratase activity
HV178_RS25325	COG0588	phosphoglycerate mutase activity
HV178_RS25330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HV178_RS25335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HV178_RS25340	COG1193	negative regulation of DNA recombination
HV178_RS25345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HV178_RS25380	COG2826	transposase and inactivated derivatives, IS30 family
HV178_RS25415	COG3039	Transposase
HV178_RS25465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV178_RS25480	COG0210	DNA helicase
HV178_RS25520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV178_RS25520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV178_RS25690	COG3039	Transposase
HV178_RS25790	COG1199	ATP-dependent helicase activity
HV178_RS25930	COG5654	RES domain protein
HV178_RS25935	COG5642	Protein of unknown function (DUF2384)
HV178_RS25985	COG1192	Involved in chromosome partitioning
HV178_RS26040	COG0305	Participates in initiation and elongation during chromosome replication
HV178_RS26185	COG3436	PFAM IS66 Orf2 family protein
HV178_RS26190	COG4372	Transposase
HV178_RS26265	COG0629	single-stranded DNA binding
HV178_RS26535	COG3039	Transposase
HV178_RS26540	COG1528	Iron-storage protein
HV178_RS26550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV178_RS26590	COG0789	Transcriptional regulator
HV178_RS26620	COG3436	PFAM IS66 Orf2 family protein
HV178_RS26625	COG4372	Transposase
HV178_RS26635	COG1309	transcriptional regulator
HV178_RS26640	COG3250	beta-galactosidase activity
HV178_RS26660	COG0246	Mannitol dehydrogenase
HV178_RS26670	COG2186	Transcriptional regulator
HV178_RS26680	COG4644	lycopene metabolic process
HV178_RS26700	COG3077	Addiction module antitoxin, RelB DinJ family
HV178_RS26705	COG2026	Addiction module toxin, RelE StbE family
HV178_RS26715	COG3039	Transposase
HV178_RS26750	COG3436	PFAM IS66 Orf2 family protein
HV178_RS26755	COG2433	Pfam Transposase IS66
HV178_RS26770	COG3039	Transposase
HV178_RS26785	COG3039	Transposase
HV178_RS26810	COG1609	Transcriptional regulator
HV178_RS26820	COG1129	ABC transporter
HV178_RS26825	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV178_RS26895	COG2610	gluconate transmembrane transporter activity
HV178_RS26900	COG3622	Belongs to the hyi family
HV178_RS26905	COG0235	Class ii aldolase
HV178_RS26910	COG3395	kinase activity
HV178_RS26915	COG2084	Dehydrogenase
HV178_RS26920	COG1349	DNA-binding transcription factor activity
HV178_RS26935	COG3039	Transposase
HV178_RS26955	COG2433	Pfam Transposase IS66
HV178_RS26960	COG3436	PFAM IS66 Orf2 family protein
HV178_RS27195	COG2176	DNA-directed DNA polymerase activity
HV178_RS27285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV178_RS27305	COG0741	lytic transglycosylase activity
HV178_RS27415	COG2002	toxin-antitoxin pair type II binding
HV178_RS27495	COG2003	Belongs to the UPF0758 family