locus-tag class description HV304_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV304_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV304_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV304_RS00025 ENOG410667J hydrolase HV304_RS00030 ENOG4107WAP fad NAD(P)-binding domain HV304_RS00035 ENOG4105D99 atp gtp-binding protein HV304_RS00040 ENOG4105R2A (LipO)protein HV304_RS00045 ENOG4108ZNX Heat shock protein HV304_RS00050 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HV304_RS00055 ENOG4105D0C transport protein HV304_RS00060 ENOG4105VG5 Membrane HV304_RS00065 ENOG4105JP4 Inner membrane protein yidG HV304_RS00070 ENOG4105J13 transcriptional regulator HV304_RS00075 ENOG4105BZC d-serine deaminase HV304_RS00095 ENOG4105E5M Multidrug resistance protein D HV304_RS00115 ENOG4105C7K acetolactate synthase HV304_RS00120 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV304_RS00125 ENOG4107FB0 transcriptional regulator DeoR family HV304_RS00135 ENOG4105EDR glucose galactose transporter HV304_RS00145 ENOG4108KX4 response regulator HV304_RS00150 ENOG4105BZU Histidine kinase HV304_RS00155 ENOG4105CXY transporter HV304_RS00160 ENOG4105CXY transporter HV304_RS00165 ENOG4108SAJ Protein of unknown function (DUF1198) HV304_RS00175 ENOG4105KDP XRE family HV304_RS00185 ENOG4105CS2 ec 3.2.1.21 HV304_RS00210 ENOG4105DAS pts system HV304_RS00215 ENOG4105ETZ PTS System HV304_RS00220 ENOG4105F3R pts system mannose fructose sorbose family iid HV304_RS00235 ENOG4105DNE Transposase HV304_RS00240 ENOG4105D01 (LipO)protein HV304_RS00245 ENOG4108UZ3 Transporter HV304_RS00255 ENOG4105CIS alcohol dehydrogenase HV304_RS00260 ENOG4105EJC lysr family transcriptional regulator HV304_RS00280 ENOG4105F2I Transposase HV304_RS00320 ENOG4105ZTC transcriptional activator, Ogr delta HV304_RS00335 ENOG4107QJE Chromosome Partitioning Protein HV304_RS00340 ENOG4105DFP Integrase HV304_RS00350 ENOG4105CT4 transporter HV304_RS00355 ENOG4105CJQ hydrolase, family 31 HV304_RS00360 ENOG4105ETD TRANSCRIPTIONal HV304_RS00365 ENOG4105DM4 PTS System HV304_RS00370 ENOG4108YRF PTS System HV304_RS00375 ENOG4105DM4 PTS System HV304_RS00380 ENOG4105D2N Aldolase HV304_RS00385 ENOG4105D2N Aldolase HV304_RS00395 ENOG4105JV1 AsmA family HV304_RS00400 ENOG4105C2W permease HV304_RS00405 ENOG4105D6U Sodium Glutamate Symporter HV304_RS00410 ENOG4105CB5 ATP-dependent DNA helicase recG HV304_RS00415 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV304_RS00420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV304_RS00435 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HV304_RS00440 ENOG4105EN6 Membrane HV304_RS00445 ENOG4105DSJ YicC domain protein HV304_RS00450 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HV304_RS00460 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HV304_RS00465 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HV304_RS00470 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV304_RS00475 ENOG4105W5Q DNA repair protein (RadC HV304_RS00485 ENOG4105W0E 50S ribosomal protein L33 HV304_RS00490 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HV304_RS00495 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HV304_RS00500 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV304_RS00505 ENOG4105DKP glycosyl transferase, family 9 HV304_RS00510 ENOG4107RJ7 Glycosyl transferase (Group 1 HV304_RS00515 ENOG4107543 (lipo)polysaccharide HV304_RS00520 ENOG4107XU6 Glycosyl transferase (Group 1 HV304_RS00525 ENOG4106AH0 Glycosyl Transferase HV304_RS00530 ENOG4105X1N Glycosyl transferase family 8 HV304_RS00535 ENOG41068D6 Glycosyltransferase HV304_RS00540 ENOG41068PG O-Antigen polymerase HV304_RS00545 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV304_RS00550 ENOG4105XA0 heptosyltransferase ii HV304_RS00560 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV304_RS00565 ENOG4105CPQ Dehydrogenase HV304_RS00570 ENOG4105K64 Glycosyl transferase, family 2 HV304_RS00575 ENOG4105PXI polysaccharide deacetylase HV304_RS00580 ENOG41063SB peptidase HV304_RS00590 ENOG4107YZP Rhodanese domain protein HV304_RS00595 ENOG4105VW4 glutaredoxin 3 HV304_RS00600 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HV304_RS00605 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HV304_RS00610 ENOG4105D7W serine acetyltransferase HV304_RS00615 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV304_RS00620 ENOG4105D2S major facilitator superfamily HV304_RS00625 ENOG4105DMF Dehydrogenase HV304_RS00630 ENOG41073TP transcriptional regulator HV304_RS00635 ENOG4105DAA L-lactate HV304_RS00640 ENOG4108YYI Protein of unknown function (DUF2810) HV304_RS00650 ENOG4105E61 Mannitol repressor protein HV304_RS00660 ENOG4105CTS PTS system mannitol-specific HV304_RS00665 ENOG4105FP6 Protein of unknown function (DUF3302) HV304_RS00670 ENOG4105EFX secretion protein, HlyD family HV304_RS00675 ENOG4108U78 Glutathione S-transferase HV304_RS00685 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV304_RS00690 ENOG4105C0A alcohol dehydrogenase HV304_RS00695 ENOG4105C26 Dehydrogenase HV304_RS00705 ENOG4105KK7 inner membrane protein YiaW HV304_RS00710 ENOG4105EFX secretion protein, HlyD family HV304_RS00715 ENOG4108Q2M Transcriptional regulator HV304_RS00720 ENOG4105GNX MltA-interacting MipA family protein HV304_RS00730 ENOG4105CT4 transporter HV304_RS00735 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV304_RS00740 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV304_RS00745 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HV304_RS00750 ENOG4105H6Q decarboxylase HV304_RS00755 ENOG4105CMG Carbohydrate kinase HV304_RS00760 ENOG4105DJB Major Facilitator Superfamily HV304_RS00770 ENOG4108R66 Conserved Protein HV304_RS00775 ENOG4105DG4 malate L-lactate dehydrogenase HV304_RS00780 ENOG4105J4Q Transcriptional regulator HV304_RS00785 ENOG4108XIB electron transport protein ysaA HV304_RS00790 ENOG4105JKW Valine--pyruvate aminotransferase HV304_RS00795 ENOG4107T9C Alpha amylase catalytic region HV304_RS00800 ENOG4108UR8 BAX protein HV304_RS00805 ENOG4105T16 Transcriptional regulator (AraC family) HV304_RS00815 ENOG4105CMG Carbohydrate kinase HV304_RS00820 ENOG410688U Inner membrane protein yiaB HV304_RS00825 ENOG4105MEV Acyl-transferase HV304_RS00840 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HV304_RS00855 ENOG4105MVF Transcriptional regulator HV304_RS00860 ENOG4106JH6 (LipO)protein HV304_RS00865 ENOG4105C5I Dehydrogenase HV304_RS00875 ENOG4105JHE Major Facilitator Superfamily HV304_RS00880 ENOG4105D7K pfkb domain protein HV304_RS00890 ENOG4108M60 Transcriptional regulator HV304_RS00895 ENOG4108ZG0 Ompa motb domain protein HV304_RS00900 ENOG4107QY8 reductase HV304_RS00905 ENOG4105HNP -acetyltransferase HV304_RS00910 ENOG4108R3E Dna-3-methyladenine glycosylase i HV304_RS00915 ENOG4105EAX Putative lipase HV304_RS00920 ENOG4105FCD Major Facilitator HV304_RS00925 ENOG4105DIJ Phosphoethanolamine transferase HV304_RS00965 ENOG4105DEF Extracellular solute-binding protein, family 5 HV304_RS00970 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV304_RS00975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV304_RS00980 ENOG4105C3U ABC transporter HV304_RS00985 ENOG4108JQ7 (ABC) transporter HV304_RS00990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV304_RS00995 ENOG4105C44 Serine transporter HV304_RS01000 ENOG4105C28 cystathionine HV304_RS01010 ENOG4105BZU Histidine kinase HV304_RS01015 ENOG4105CK2 sodium dicarboxylate symporter HV304_RS01020 ENOG4105CS0 peptidase HV304_RS01025 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HV304_RS01030 ENOG4105CMB EAL domain-containing protein HV304_RS01035 ENOG41066T0 asmA family HV304_RS01040 ENOG4105CSH Transporter HV304_RS01045 ENOG4107H3J ribonuclease HV304_RS01050 ENOG4105CBN LysR family transcriptional regulator HV304_RS01055 ENOG4105CHR reductase HV304_RS01065 ENOG4105BZU Histidine kinase HV304_RS01070 ENOG4106S2D Transcriptional regulator HV304_RS01080 ENOG41068WN HV304_RS01095 ENOG4105CA0 peroxidase HV304_RS01105 ENOG4105DC8 reductase HV304_RS01110 ENOG4105D6S protein involved in catabolism of external DNA HV304_RS01115 ENOG4105DGW oligopeptidase A HV304_RS01120 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HV304_RS01130 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV304_RS01135 ENOG4105DUX Transporter HV304_RS01145 ENOG4108V6B universal stress protein B HV304_RS01150 ENOG4105CJ3 phosphate transporter HV304_RS01155 ENOG4105CBX hi0933 family HV304_RS01165 ENOG4105F2I Transposase HV304_RS01175 ENOG4105CJW magnesium transporter HV304_RS01180 ENOG4105D0S secretion protein (HlyD HV304_RS01185 ENOG4105CJ1 ABC, transporter HV304_RS01190 ENOG4105CMI transporter HV304_RS01205 ENOG4105MRR Transcriptional regulator (By similarity) HV304_RS01210 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HV304_RS01215 ENOG4105DSF transport protein HV304_RS01220 ENOG4105F9N Major Facilitator Superfamily HV304_RS01225 ENOG4108W1V Lipoprotein HV304_RS01230 ENOG4105EX9 Membrane HV304_RS01235 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HV304_RS01245 ENOG4107FS9 Membrane HV304_RS01270 ENOG4105MG3 Membrane HV304_RS01275 ENOG4106H78 methyltransferase HV304_RS01280 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV304_RS01285 ENOG4105CAK Cell division ATP-binding protein ftsE HV304_RS01290 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV304_RS01310 ENOG4105U59 -acetyltransferase HV304_RS01315 ENOG4105CP9 extracellular ligand-binding receptor HV304_RS01320 ENOG4105C32 Amino acid ABC transporter (Permease) HV304_RS01325 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV304_RS01330 ENOG4105C0Z ABC transporter HV304_RS01335 ENOG4108IV0 ABC, transporter HV304_RS01345 ENOG4105BZ7 extracellular solute-binding protein family 1 HV304_RS01350 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV304_RS01360 ENOG4108IJ9 (ABC) transporter HV304_RS01365 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV304_RS01370 ENOG4105WC8 Conserved Protein HV304_RS01375 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV304_RS01380 ENOG41080QX K07048 phosphotriesterase-related protein HV304_RS01395 ENOG4108RVA ribokinase HV304_RS01405 ENOG4105WCN acetyltransferase HV304_RS01410 ENOG4105D9R oxidoreductase HV304_RS01415 ENOG4105C2I pirin domain protein HV304_RS01420 ENOG4105DIQ Transcriptional regulator HV304_RS01425 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV304_RS01430 ENOG4105C6Z Gluconate HV304_RS01445 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HV304_RS01450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV304_RS01455 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV304_RS01460 ENOG4108IUM Glycogen debranching enzyme HV304_RS01470 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HV304_RS01475 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV304_RS01480 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV304_RS01485 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HV304_RS01490 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HV304_RS01495 ENOG4105E98 transcriptional regulator DeoR family HV304_RS01500 ENOG41061ZR Transcriptional regulator HV304_RS01505 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV304_RS01510 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV304_RS01515 ENOG4105C6Z Gluconate HV304_RS01520 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HV304_RS01525 ENOG4105MJ2 Competence protein HV304_RS01535 ENOG4105DNE Transposase HV304_RS01545 ENOG4105CE1 Ferrous iron transport protein b HV304_RS01550 ENOG4105XFK Ferrous iron transport protein A HV304_RS01555 ENOG4105BZM domain protein HV304_RS01560 ENOG4108RRZ Transcription elongation factor GreB HV304_RS01570 ENOG4105E0F Histidine kinase HV304_RS01585 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HV304_RS01590 ENOG4108MAJ Membrane HV304_RS01600 ENOG4105VEJ Heat shock protein HV304_RS01605 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV304_RS01615 ENOG4107RK2 ADP-ribose diphosphatase NudE HV304_RS01620 ENOG4108JQC penicillin-binding protein 1A HV304_RS01625 ENOG4108U1Q Pilus assembly protein HV304_RS01630 ENOG41065NF Fimbrial assembly family protein HV304_RS01635 ENOG4105XPX DNA utilization protein HofO HV304_RS01640 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HV304_RS01645 ENOG4105E4G Type IV pilus HV304_RS01650 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV304_RS01655 ENOG4105D49 3-dehydroquinate synthase HV304_RS01660 ENOG4105EGB membrane protein DamX HV304_RS01665 ENOG4105DFE Dna adenine methylase HV304_RS01670 ENOG4105DJV ribulose-phosphate 3-epimerase HV304_RS01675 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HV304_RS01680 ENOG4105C31 Tryptophanyl-tRNA synthetase HV304_RS01685 ENOG4108M21 HV304_RS01695 ENOG4108626 Racemase HV304_RS01700 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HV304_RS01705 ENOG41080QX K07048 phosphotriesterase-related protein HV304_RS01710 ENOG4105MUZ Protein of unknown function DUF2620 HV304_RS01715 ENOG4106M0N transport system permease protein HV304_RS01720 ENOG4106PKC pyridoxal phosphate binding HV304_RS01725 ENOG4105VYH HV304_RS01735 ENOG4107V9H nitrite transporter HV304_RS01740 ENOG4105WZK nitrite reductase NADPH small subunit HV304_RS01745 ENOG4107QZF nitrite reductase NADPH large subunit HV304_RS01755 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV304_RS01760 ENOG4106195 uncharacterized protein yhfG HV304_RS01765 ENOG4105MZU cell filamentation protein HV304_RS01770 ENOG4105DDQ anthranilate synthase HV304_RS01775 ENOG4105C8Y Acetylornithine aminotransferase HV304_RS01780 ENOG410613R integral membrane protein, YccS YhfK family HV304_RS01785 ENOG4107RYR Transcriptional regulator, Crp Fnr family HV304_RS01790 ENOG4108UKZ OsmC family HV304_RS01795 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV304_RS01805 ENOG4105DNZ Alpha Beta Hydrolase HV304_RS01815 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV304_RS01825 ENOG4105C5H ABC transporter HV304_RS01830 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HV304_RS01835 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV304_RS01840 ENOG4105VKU nucleicacid-binding protein HV304_RS01845 ENOG4108YZY peptidylprolyl cis-trans isomerase HV304_RS01850 ENOG4105VRX Protein slyX homolog HV304_RS01855 ENOG4108V1T peptidylprolyl cis-trans isomerase HV304_RS01860 ENOG4105WWK YheO domain protein HV304_RS01865 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HV304_RS01870 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV304_RS01875 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV304_RS01885 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HV304_RS01890 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV304_RS01900 ENOG4105W53 bacterioferritin-associated ferredoxin HV304_RS01905 ENOG4108UQY Iron-storage protein HV304_RS01910 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HV304_RS01920 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HV304_RS01925 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HV304_RS01940 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HV304_RS01945 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HV304_RS01960 ENOG41083MP 50s ribosomal protein l29 HV304_RS01965 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HV304_RS01985 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HV304_RS01995 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HV304_RS02005 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HV304_RS02010 ENOG4105VPB 50S ribosomal protein L30 HV304_RS02015 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HV304_RS02020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV304_RS02025 ENOG41067V7 50S ribosomal protein L36 HV304_RS02035 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HV304_RS02055 ENOG4105VTS DnaJ-like, subfamily C HV304_RS02060 ENOG4105W1Y Transcriptional regulator HV304_RS02065 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV304_RS02070 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HV304_RS02075 ENOG4105C1A potassium transporter peripheral membrane HV304_RS02090 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HV304_RS02095 ENOG4105C79 DNA protecting protein DprA HV304_RS02105 ENOG4108WI1 Dna topoisomerase HV304_RS02110 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV304_RS02115 ENOG4105E2X shikimate dehydrogenase HV304_RS02120 ENOG4105SG3 Protein of unknown function (DUF1488) HV304_RS02125 ENOG4108Z0R Transferase HV304_RS02165 ENOG4105CDA abc transporter atp-binding protein HV304_RS02170 ENOG4105DRP amino acid AbC transporter HV304_RS02175 ENOG4105EZ7 amino acid ABC transporter HV304_RS02185 ENOG4105XCM membrane LIPOPROTEIN HV304_RS02190 ENOG4105BZS acriflavin resistance protein HV304_RS02195 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV304_RS02200 ENOG4108XG4 DNA-binding transcriptional regulator HV304_RS02205 ENOG41061ME transport protein HV304_RS02210 ENOG4105CEC DNA methylase N-4 N-6 HV304_RS02220 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV304_RS02235 ENOG4108IA2 Sodium pantothenate symporter HV304_RS02240 ENOG4105RG0 Membrane HV304_RS02245 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV304_RS02250 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV304_RS02255 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HV304_RS02265 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV304_RS02270 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV304_RS02285 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV304_RS02290 ENOG4105VQ7 Rod shape-determining protein MreD HV304_RS02300 ENOG4105C03 ribonuclease HV304_RS02305 ENOG4105QD6 exported protein HV304_RS02310 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV304_RS02315 ENOG4105CR8 Transcriptional regulator HV304_RS02320 ENOG4105ZQC membrane protein AaeX HV304_RS02325 ENOG4105Y49 secretion protein, HlyD family HV304_RS02330 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HV304_RS02335 ENOG4105UNR (Barnase) inhibitor HV304_RS02345 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV304_RS02355 ENOG4105C0H protease HV304_RS02360 ENOG4105C0H protease HV304_RS02365 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV304_RS02370 ENOG4105D6Z AFG1 family ATPase HV304_RS02375 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HV304_RS02385 ENOG4107MKT Stringent starvation protein a HV304_RS02390 ENOG4105KB2 stringent starvation protein b HV304_RS02395 ENOG4105CEE C4-dicarboxylate transporter HV304_RS02405 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV304_RS02410 ENOG4105JHE Major Facilitator Superfamily HV304_RS02415 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HV304_RS02420 ENOG4108R66 Conserved Protein HV304_RS02425 ENOG4105DZC cytosine deaminase HV304_RS02430 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV304_RS02435 ENOG4105DFS Conserved Protein HV304_RS02440 ENOG4105BZ8 glutamate synthase HV304_RS02445 ENOG4105CBC glutamate synthase HV304_RS02450 ENOG4105N5T Radical SAM Protein HV304_RS02455 ENOG4105BZU Histidine kinase HV304_RS02460 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV304_RS02465 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HV304_RS02470 ENOG41080Z8 PHOSPHOCARRIER protein HV304_RS02475 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HV304_RS02480 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV304_RS02485 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV304_RS02490 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV304_RS02495 ENOG4108IUZ ABC transporter HV304_RS02500 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV304_RS02505 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV304_RS02510 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HV304_RS02515 ENOG4105C2X Arabinose 5-phosphate isomerase HV304_RS02520 ENOG4105FEU K -dependent Na -Ca exchanger HV304_RS02525 ENOG4105DHJ ABC, transporter HV304_RS02530 ENOG4105CY3 ABC transporter, permease HV304_RS02535 ENOG4107PE3 Mammalian cell entry related domain protein HV304_RS02540 ENOG4105E3I toluene tolerance HV304_RS02545 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV304_RS02550 ENOG4105VFK BolA family HV304_RS02560 ENOG4105HVQ Regulatory factor of maltose metabolism HV304_RS02565 ENOG4105EAH synthase HV304_RS02570 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HV304_RS02575 ENOG4105K46 50S ribosomal protein l27 HV304_RS02580 ENOG4105QYV Membrane HV304_RS02585 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HV304_RS02590 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV304_RS02595 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV304_RS02600 ENOG4105HBR Rna-binding protein HV304_RS02610 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV304_RS02615 ENOG4105EEI dihydropteroate synthase HV304_RS02620 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HV304_RS02625 ENOG4105CEE C4-dicarboxylate transporter HV304_RS02630 ENOG4105DYB Isoaspartyl dipeptidase HV304_RS02635 ENOG4107YNJ LysR family Transcriptional regulator HV304_RS02640 ENOG4105NTZ Preprotein translocase subunit SecG HV304_RS02650 ENOG4105CDH Citrulline--aspartate ligase HV304_RS02660 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HV304_RS02665 ENOG4105CHV Transcription elongation factor NusA HV304_RS02670 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HV304_RS02675 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HV304_RS02705 ENOG4105C1J atp-dependent rna helicase HV304_RS02710 ENOG4105CIC tryptophan-specific transport protein HV304_RS02715 ENOG4105DEN Luciferase family HV304_RS02735 ENOG4108YYD acetyltransferase HV304_RS02740 ENOG41082IR Excinuclease ABC C subunit domain protein HV304_RS02745 ENOG4108ZPB UPF0306 protein HV304_RS02750 ENOG4105K4T epimerase HV304_RS02755 ENOG4105W4M Transport-associated protein HV304_RS02760 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HV304_RS02775 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV304_RS02780 ENOG4105D2N Aldolase HV304_RS02785 ENOG4105E70 isomerase HV304_RS02790 ENOG4105CE4 GlcNAc 6-P deacetylase HV304_RS02795 ENOG4108YTN IIa component HV304_RS02800 ENOG4105F3R pts system mannose fructose sorbose family iid HV304_RS02810 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HV304_RS02815 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HV304_RS02820 ENOG4105E98 transcriptional regulator DeoR family HV304_RS02825 ENOG4105E98 transcriptional regulator DeoR family HV304_RS02830 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HV304_RS02840 ENOG4108IJ9 (ABC) transporter HV304_RS02845 ENOG4105DRS transport system, permease HV304_RS02860 ENOG4105CTX dehydratase HV304_RS02865 ENOG4105DJB Major Facilitator Superfamily HV304_RS02870 ENOG4105CNV Aldolase HV304_RS02875 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV304_RS02880 ENOG4105BZW Glycerate kinase HV304_RS02905 ENOG4105I03 Flagellin HV304_RS02925 ENOG410811B TRANSCRIPTIONal HV304_RS02930 ENOG4105C7B Threonine dehydratase HV304_RS02935 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HV304_RS02945 ENOG4105C6N Formate acetyltransferase HV304_RS02950 ENOG4105KME endoribonuclease L-psp HV304_RS02955 ENOG4105EJQ L-serine dehydratase HV304_RS02960 ENOG4105C44 Serine transporter HV304_RS02970 ENOG4106D80 Uncharacterized protein YhaL HV304_RS02975 ENOG4108CNN domain protein HV304_RS02980 ENOG4105CWB LysR family transcriptional Regulator HV304_RS02985 ENOG4105KAF membrAne HV304_RS02990 ENOG4105CHF Glutathione S-transferase HV304_RS02995 ENOG4108VBZ doxx family HV304_RS03000 ENOG4105YJD HV304_RS03005 ENOG41090KG Inner membrane protein YqjE HV304_RS03010 ENOG4105NE1 Conserved Protein HV304_RS03015 ENOG4105WAY exported protein HV304_RS03025 ENOG4106W5V Membrane HV304_RS03030 ENOG4107YCY Transcriptional regulator HV304_RS03035 ENOG4105DPW Major facilitator superfamily MFS_1 HV304_RS03045 ENOG4105CTX dehydratase HV304_RS03050 ENOG4105P66 Membrane HV304_RS03060 ENOG4105DU1 integral membrane protein, terc HV304_RS03065 ENOG4105EE0 oxidoreductase HV304_RS03070 ENOG4108VKG metal-dependent hydrolase HV304_RS03075 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV304_RS03080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV304_RS03085 ENOG4107WCA isomerase HV304_RS03090 ENOG4107W6W Conserved Protein HV304_RS03095 ENOG4105E5D amino acid HV304_RS03100 ENOG4105FK9 beta-D-galactosidase beta subunit HV304_RS03105 ENOG4105CNT hydrolase family 2 HV304_RS03110 ENOG4105CQ4 Transcriptional regulator HV304_RS03115 ENOG4108Y51 tRNA-binding protein HV304_RS03120 ENOG4105C8Y Acetylornithine aminotransferase HV304_RS03125 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV304_RS03130 ENOG4105NTW Transcriptional regulator HV304_RS03135 ENOG4105Q26 Siderophore-interacting protein HV304_RS03145 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV304_RS03190 ENOG4105YCI dehydratase medium subunit HV304_RS03195 ENOG4108ZFT Dehydratase small subunit HV304_RS03200 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV304_RS03205 ENOG4105V2F Uncharacterized protein yoac HV304_RS03215 ENOG4105MZU cell filamentation protein HV304_RS03235 ENOG4108P8R HV304_RS03270 ENOG4108MXD gtp-binding protein HV304_RS03275 ENOG4106H6R UPF0380 protein HV304_RS03280 ENOG4108KZE transcriptional regulator HV304_RS03295 ENOG4106ZN7 UPF0401 protein YkfF HV304_RS03300 ENOG4105MFG Antirestriction protein HV304_RS03305 ENOG4108XS9 dna repair protein HV304_RS03310 ENOG4105ZS6 Protein of unknown function (DUF987) HV304_RS03315 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV304_RS03320 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV304_RS03340 ENOG4105D05 Receptor HV304_RS03345 ENOG4108NS2 receptor HV304_RS03350 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV304_RS03355 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV304_RS03365 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV304_RS03370 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HV304_RS03375 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV304_RS03380 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HV304_RS03385 ENOG4105CQM Urea amidohydrolase subunit alpha HV304_RS03390 ENOG4105KI2 Urea amidohydrolase subunit beta HV304_RS03395 ENOG4108YZ9 Urea amidohydrolase subunit gamma HV304_RS03400 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV304_RS03405 ENOG4107QPK )-transporter HV304_RS03410 ENOG4107GFK fumarate HV304_RS03415 ENOG4106DSS Tartrate dehydratase subunit alpha HV304_RS03420 ENOG4105EJC lysr family transcriptional regulator HV304_RS03425 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HV304_RS03430 ENOG4107ZVW dihydroneopterin aldolase HV304_RS03435 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HV304_RS03440 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HV304_RS03445 ENOG4106MWK domain protein HV304_RS03450 ENOG4105I7R Adenylate cyclase HV304_RS03455 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HV304_RS03460 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HV304_RS03465 ENOG4107S78 Band 7 protein HV304_RS03470 ENOG4105PV3 Inner membrane protein yqiJ HV304_RS03480 ENOG4105W0Z cytoplasmic protein HV304_RS03490 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) HV304_RS03500 ENOG4108MR7 Arylsulfotransferase HV304_RS03510 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV304_RS03515 ENOG4106032 Glutathionylspermidine synthase HV304_RS03520 ENOG4105F1G UPF0441 protein HV304_RS03525 ENOG4105DFG type I secretion outer membrane protein HV304_RS03530 ENOG41087AY ADP-Ribose pyrophosphatase HV304_RS03535 ENOG4108SX3 cytoplasmic protein HV304_RS03540 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV304_RS03545 ENOG4105IPS esterase HV304_RS03550 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV304_RS03555 ENOG4105ID8 Transcriptional regulator, ARAC family HV304_RS03565 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV304_RS03570 ENOG4105EP8 Glycosyl Hydrolase Family 88 HV304_RS03575 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV304_RS03580 ENOG4105NF4 modulator of drug activity HV304_RS03585 ENOG4105DHQ Histidine kinase HV304_RS03590 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV304_RS03595 ENOG4105H4F exported protein HV304_RS03600 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV304_RS03605 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV304_RS03610 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV304_RS03615 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV304_RS03620 ENOG4105CCT upf0313 protein HV304_RS03630 ENOG4107QPK )-transporter HV304_RS03635 ENOG4105CV8 reductase HV304_RS03640 ENOG4108I6A alcohol dehydrogenase HV304_RS03645 ENOG4105CF7 AraC family transcriptional regulator HV304_RS03650 ENOG4108K81 inner membrane protein YghB HV304_RS03655 ENOG4105C28 cystathionine HV304_RS03660 ENOG4105CWK Biopolymer transport protein, ExbB HV304_RS03665 ENOG4108ZZF transport protein (ExbD) HV304_RS03685 ENOG4105CPC Aldo Keto reductase HV304_RS03695 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS03700 ENOG410900S Protein of unknown function (DUF2623) HV304_RS03705 ENOG4105E3S small subunit HV304_RS03710 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV304_RS03715 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HV304_RS03720 ENOG4105DPX Hydrogenase, large subunit HV304_RS03725 ENOG4108USZ hydrogenase HV304_RS03730 ENOG4108WGS hydrogenase 2-specific chaperone HV304_RS03735 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV304_RS03740 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HV304_RS03745 ENOG4105CYM Glutathione S-transferase HV304_RS03750 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HV304_RS03755 ENOG4106032 Glutathionylspermidine synthase HV304_RS03785 ENOG4105ZS6 Protein of unknown function (DUF987) HV304_RS03790 ENOG4108XS9 dna repair protein HV304_RS03795 ENOG4106549 Antirestriction protein HV304_RS03800 ENOG4106ZN7 UPF0401 protein YkfF HV304_RS03805 ENOG4106J9S Prophage HV304_RS03820 ENOG4108KZE transcriptional regulator HV304_RS03825 ENOG4106H6R UPF0380 protein HV304_RS03830 ENOG4108MXD gtp-binding protein HV304_RS03855 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV304_RS03865 ENOG4105D6F Phosphatase HV304_RS03880 ENOG4105D58 Diguanylate phosphodiesterase HV304_RS03890 ENOG4108BUD transposase HV304_RS03905 ENOG4105F2I Transposase HV304_RS03915 ENOG4108BUD transposase HV304_RS03920 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS03935 ENOG4105F9F transposase HV304_RS03970 ENOG4105CXN decarboxylase HV304_RS03975 ENOG4105EAA nucleoside HV304_RS03980 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HV304_RS03985 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HV304_RS03990 ENOG4105CEN a g-specific adenine glycosylase HV304_RS03995 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HV304_RS04000 ENOG41090ED Protein with unknown function (DUF469) HV304_RS04005 ENOG4105K33 Periplasmic Protein HV304_RS04010 ENOG4105HDK L-asparaginase HV304_RS04015 ENOG4105CSA Coproporphyrinogen iii oxidase HV304_RS04020 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV304_RS04025 ENOG4105VZ9 UPF0235 protein HV304_RS04030 ENOG4108VIA integral membrane protein HV304_RS04035 ENOG4105DFA alanine racemase domain protein HV304_RS04040 ENOG4105CZX twitching motility protein HV304_RS04045 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HV304_RS04050 ENOG4108UJU UPF0301 protein HV304_RS04055 ENOG4105D7Z glutathione synthase HV304_RS04060 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV304_RS04065 ENOG4105RWS endonuclease I HV304_RS04070 ENOG4105GPY SprT protein HV304_RS04075 ENOG4107QNK )-transporter HV304_RS04080 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HV304_RS04095 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV304_RS04105 ENOG4108K0D peptidase, M48 HV304_RS04110 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV304_RS04115 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV304_RS04120 ENOG4105CTS PTS system mannitol-specific HV304_RS04125 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV304_RS04130 ENOG4108Q8A Fructose-1,6-bisphosphatase HV304_RS04135 ENOG4108R4K DNA-binding, transcriptional regulator HV304_RS04140 ENOG4107Z1W Fructose transport system kinase HV304_RS04145 ENOG4105BZ1 (ABC) transporter HV304_RS04150 ENOG4108JJB ABC transporter HV304_RS04170 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV304_RS04175 ENOG4105BZA Phosphoglycerate kinase HV304_RS04180 ENOG4105D2N Aldolase HV304_RS04185 ENOG4105D64 Mechanosensitive ion channel HV304_RS04190 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HV304_RS04195 ENOG4105MPN Membrane HV304_RS04200 ENOG4105DEQ transcriptional regulator HV304_RS04205 ENOG4105CYC Transferase HV304_RS04210 ENOG4108M7F enoyl-CoA hydratase isomerase HV304_RS04215 ENOG4105DJT lAO AO transport system ATPase HV304_RS04220 ENOG4105D5P Methylmalonyl-coA mutase HV304_RS04225 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HV304_RS04235 ENOG4108JQ1 Dehydrogenase HV304_RS04240 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV304_RS04250 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HV304_RS04260 ENOG4107RAQ aminopeptidase HV304_RS04265 ENOG4105D0A hydroxylase HV304_RS04270 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV304_RS04285 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HV304_RS04290 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV304_RS04295 ENOG4105CS2 ec 3.2.1.21 HV304_RS04300 ENOG4108Q3X Transcriptional regulator HV304_RS04310 ENOG4108UT2 hemolysin iii HV304_RS04320 ENOG4105Y75 tpr repeat protein HV304_RS04325 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV304_RS04330 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV304_RS04335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV304_RS04340 ENOG4105T95 Thiol disulfide interChange protein HV304_RS04345 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV304_RS04355 ENOG4105CRK lysyL-tRNA synthetase HV304_RS04365 ENOG4108K5P (LipO)protein HV304_RS04375 ENOG4105DFP Integrase HV304_RS04405 ENOG410624V efflux system protein HV304_RS04435 ENOG4105DR5 peptidase HV304_RS04445 ENOG4105E3B Multicopper oxidase HV304_RS04450 ENOG4105VR0 copper resistance HV304_RS04455 ENOG4105JDN Copper resistance protein HV304_RS04460 ENOG4108PG2 copper resistance HV304_RS04465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV304_RS04470 ENOG4105GR3 Histidine kinase HV304_RS04535 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV304_RS04565 ENOG4105TS0 gtp-binding protein HV304_RS04570 ENOG4106H6R UPF0380 protein HV304_RS04575 ENOG4108KZE transcriptional regulator HV304_RS04595 ENOG4106ZN7 UPF0401 protein YkfF HV304_RS04600 ENOG4105MFG Antirestriction protein HV304_RS04605 ENOG4108XS9 dna repair protein HV304_RS04610 ENOG4105ZS6 Protein of unknown function (DUF987) HV304_RS04615 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV304_RS04620 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV304_RS04630 ENOG4105F2I Transposase HV304_RS04635 ENOG4108TUY outer membrane protein PgaA HV304_RS04640 ENOG4107BJW polysaccharide deacetylase HV304_RS04645 ENOG4105CND Glycosyl transferase, family 2 HV304_RS04655 ENOG4105VR1 Pfam:DUF1271 HV304_RS04660 ENOG410830R acetyltransferase HV304_RS04665 ENOG4108NUU Transcriptional regulator HV304_RS04670 ENOG4107SNB ankyrin repeat protein YahD HV304_RS04675 ENOG4105N16 Protein of unknown function (DUF2877) HV304_RS04680 ENOG4107R1Q Membrane protein FdrA HV304_RS04685 ENOG4107REC cytoplasmic protein HV304_RS04695 ENOG4105C5B carbamate kinase HV304_RS04700 ENOG4105DZC cytosine deaminase HV304_RS04705 ENOG41061MD high-affinity nickel-transporter HV304_RS04715 ENOG4108MHD transport protein HV304_RS04725 ENOG4105C5Q Transcriptional regulator HV304_RS04730 ENOG4105CHU acetyl-coa acetyltransferase HV304_RS04740 ENOG4105CHR reductase HV304_RS04745 ENOG4107QNK )-transporter HV304_RS04750 ENOG4105DNE Transposase HV304_RS04765 ENOG4105RQF LysR family Transcriptional regulator HV304_RS04775 ENOG4105DDV Transcriptional regulator (LacI family HV304_RS04790 ENOG4107S74 Lysophospholipid transporter LplT HV304_RS04795 ENOG4105CPC Aldo Keto reductase HV304_RS04800 ENOG4105SUV lipoprotein YgdR HV304_RS04805 ENOG4105EE5 Membrane protein terC HV304_RS04820 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV304_RS04835 ENOG4105IPU prepilin peptidase dependent protein A HV304_RS04840 ENOG4105JCS prepilin peptidase dependent protein HV304_RS04845 ENOG4105SEN Protein of unknown function (DUF2509) HV304_RS04850 ENOG4105RVB Prepilin peptidase dependent protein c HV304_RS04855 ENOG4105DSY exodeoxyribonuclease V, gamma HV304_RS04860 ENOG4107QXK peptidase HV304_RS04865 ENOG4107QKA exodeoxyribonuclease V beta HV304_RS04870 ENOG4107QYX exodeoxyribonuclease v alpha HV304_RS04875 ENOG4108EKC n-acetylglutamate synthase HV304_RS04880 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV304_RS04910 ENOG4108VEV chaperone HV304_RS04915 ENOG4105CW0 outer membrane usher protein HV304_RS04950 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV304_RS04955 ENOG4105CUZ uba thif-type nad fad binding protein HV304_RS04960 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV304_RS04965 ENOG4105C9B Cysteine desulfurase HV304_RS04970 ENOG4105M5B (LipO)protein HV304_RS04975 ENOG4105ETT transcriptional Regulator, LysR family HV304_RS04980 ENOG4105M08 Membrane HV304_RS04985 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HV304_RS04990 ENOG4107EDW L-fucose operon activator HV304_RS05000 ENOG4105CMG Carbohydrate kinase HV304_RS05005 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HV304_RS05010 ENOG4105C2J ABC transporter HV304_RS05015 ENOG4105CNN ABC, transporter HV304_RS05025 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV304_RS05035 ENOG4107W7X Aldolase HV304_RS05040 ENOG4105C0A alcohol dehydrogenase HV304_RS05050 ENOG4105EJQ L-serine dehydratase HV304_RS05055 ENOG4105C44 Serine transporter HV304_RS05060 ENOG4105EWT decarboxylase family HV304_RS05065 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HV304_RS05070 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HV304_RS05075 ENOG4105WP7 tRNA pseudouridine synthase C HV304_RS05080 ENOG4105DR9 pseudouridine synthase HV304_RS05085 ENOG4105QDK Flavodoxin HV304_RS05090 ENOG4105DJB Major Facilitator Superfamily HV304_RS05095 ENOG4105EQX glucarate dehydratase HV304_RS05100 ENOG4105EQX glucarate dehydratase HV304_RS05105 ENOG4105BZW Glycerate kinase HV304_RS05110 ENOG4105BZU Histidine kinase HV304_RS05115 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HV304_RS05120 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV304_RS05125 ENOG4105DXN mazG family HV304_RS05130 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV304_RS05140 ENOG4105QEK Transcriptional regulator HV304_RS05150 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HV304_RS05155 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV304_RS05160 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV304_RS05165 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HV304_RS05175 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HV304_RS05180 ENOG4108MXK alkaline phosphatase isozyme conversion HV304_RS05190 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HV304_RS05200 ENOG4105N0Z inner membrane protein ygbE HV304_RS05205 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV304_RS05210 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HV304_RS05220 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HV304_RS05225 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HV304_RS05230 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HV304_RS05235 ENOG4108K5P (LipO)protein HV304_RS05250 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV304_RS05255 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV304_RS05260 ENOG4105KZM cytoplasmic protein HV304_RS05265 ENOG4107635 Hok Gef family protein HV304_RS05295 ENOG4105C4R Atp-dependent dna helicase HV304_RS05365 ENOG4105DSF transport protein HV304_RS05370 ENOG4105BZS acriflavin resistance protein HV304_RS05375 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV304_RS05390 ENOG4105F1A Pyruvate formate-lyase HV304_RS05395 ENOG4105C6N Formate acetyltransferase HV304_RS05410 ENOG4105CC5 ABC transporter HV304_RS05415 ENOG4105CC5 ABC transporter HV304_RS05420 ENOG4105DIK (ABC) transporter HV304_RS05440 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HV304_RS05445 ENOG4108Q3X Transcriptional regulator HV304_RS05450 ENOG4105CEE C4-dicarboxylate transporter HV304_RS05455 ENOG4107R1I NAD-dependent malic enzyme HV304_RS05460 ENOG4105VXR cytoplasmic protein HV304_RS05470 ENOG4105C45 hydrogenase expression formation protein (HypE) HV304_RS05475 ENOG4105CQS hydrogenase expression formation protein HypD HV304_RS05480 ENOG41083WG hydrogenase assembly chaperone HV304_RS05485 ENOG4107RSS Hydrogenase accessory protein HypB HV304_RS05490 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV304_RS05495 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV304_RS05500 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV304_RS05505 ENOG4107R30 NADH dehydrogenase HV304_RS05510 ENOG4107TDF Formate hydrogenlyase subunit 4 HV304_RS05515 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV304_RS05520 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV304_RS05525 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV304_RS05530 ENOG4105I6X formate hydrogenlyase maturation HV304_RS05535 ENOG4108MG9 hydrogenase 3 maturation protease HV304_RS05545 ENOG4105CS2 ec 3.2.1.21 HV304_RS05550 ENOG4105C5Y PTS System HV304_RS05555 ENOG4105DDV Transcriptional regulator (LacI family HV304_RS05560 ENOG4108RC0 Electron transport protein HV304_RS05565 ENOG4105C8H hydrogenase maturation protein Hypf HV304_RS05570 ENOG4107QZF nitrite reductase NADPH large subunit HV304_RS05575 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HV304_RS05580 ENOG4108JUA Transcriptional regulator HV304_RS05585 ENOG4105C2X Arabinose 5-phosphate isomerase HV304_RS05590 ENOG410804X Transcriptional regulator HV304_RS05595 ENOG4105J92 DNA-binding transcriptional activator GutM HV304_RS05600 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HV304_RS05605 ENOG4105VI0 Pts system, glucitol sorbitol-specific HV304_RS05610 ENOG4105DZY Pts system, glucitol sorbitol-specific HV304_RS05615 ENOG410787A Pts system, glucitol sorbitol-specific HV304_RS05620 ENOG4105CVE Lytic murein transglycosylase HV304_RS05625 ENOG4107TH8 cina domain protein HV304_RS05630 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HV304_RS05640 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HV304_RS05645 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV304_RS05675 ENOG4107VXZ Hydrolase HV304_RS05680 ENOG4105W39 Membrane HV304_RS05700 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV304_RS05705 ENOG4105CW7 secretion protein, HlyD family HV304_RS05710 ENOG4105NTK Transcriptional repressor Mpra HV304_RS05715 ENOG4105ZED uncharacterized protein ygaH HV304_RS05720 ENOG4108UMN azlc family HV304_RS05730 ENOG4105GIJ Glycine betaine HV304_RS05735 ENOG4108HQS Glycine betaine HV304_RS05740 ENOG4108IJ7 Glycine betaine HV304_RS05745 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV304_RS05755 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS05765 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HV304_RS05770 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV304_RS05775 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV304_RS05785 ENOG4108WMJ Protein of unknown function (DUF2002) HV304_RS05790 ENOG4108RNS Exports L-alanine (By similarity) HV304_RS05795 ENOG4108X73 DNA- binding protein HV304_RS05805 ENOG4108V62 Rhodanese domain protein HV304_RS05810 ENOG41080HT Transcriptional regulator, arsr family HV304_RS05815 ENOG4105VPI YqaE family transport protein HV304_RS05820 ENOG4109066 lysm domain bon superfamily protein HV304_RS05825 ENOG4108PVQ transcriptional regulator HV304_RS05830 ENOG4105C85 amino acid HV304_RS05835 ENOG4108JPW Aminotransferase HV304_RS05840 ENOG4105C26 Dehydrogenase HV304_RS05845 ENOG4105D5U fad dependent oxidoreductase HV304_RS05855 ENOG4105KT7 mgtC SapB transporter HV304_RS05860 ENOG4105EAA nucleoside HV304_RS05905 ENOG4105DHQ Histidine kinase HV304_RS05915 ENOG4105CW0 outer membrane usher protein HV304_RS05920 ENOG4108NAE Fimbrial chaperone protein HV304_RS05975 ENOG41088YS Glycosyl transferase (Group 1 HV304_RS05980 ENOG4107RA4 Glycosyl transferase (Group 1 HV304_RS05995 ENOG4105CMR udp-glucose 4-epimerase HV304_RS06005 ENOG4107B2H carbonic anhydrase HV304_RS06020 ENOG4105F2I Transposase HV304_RS06030 ENOG4105H5P transposase HV304_RS06035 ENOG4108P8R HV304_RS06040 ENOG410679B prophage CP4-57 regulatory protein alpA HV304_RS06050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV304_RS06080 ENOG4105DFP Integrase HV304_RS06095 ENOG4105BZ1 (ABC) transporter HV304_RS06115 ENOG4108Z1B Cyclase dehydrase HV304_RS06120 ENOG4105VDB UPF0125 protein HV304_RS06125 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV304_RS06130 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV304_RS06145 ENOG4108JU6 CBS domain protein HV304_RS06150 ENOG4106KVJ cytochrome C assembly protein HV304_RS06155 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV304_RS06160 ENOG4105K5M 30s ribosomal protein S16 HV304_RS06165 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HV304_RS06175 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HV304_RS06180 ENOG41090EK ompa motb domain protein HV304_RS06185 ENOG4108KHX Diguanylate cyclase HV304_RS06190 ENOG4108WS1 HV304_RS06195 ENOG4105QP9 Protein of unknown function (DUF2799) HV304_RS06200 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV304_RS06205 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV304_RS06210 ENOG4105CQC Prephenate dehydratase HV304_RS06220 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV304_RS06225 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV304_RS06230 ENOG4105C34 Pseudouridine synthase HV304_RS06235 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV304_RS06240 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV304_RS06265 ENOG4105CSH Transporter HV304_RS06270 ENOG4105T42 (LipO)protein HV304_RS06275 ENOG4105JIM Phosphatidylserine synthase HV304_RS06280 ENOG4105CD5 CoA-binding domain protein HV304_RS06285 ENOG4106IUH DTW domain containing protein HV304_RS06290 ENOG4105K63 Thioredoxin HV304_RS06295 ENOG4105EIB trna rrna methyltransferase HV304_RS06320 ENOG4105C1J atp-dependent rna helicase HV304_RS06330 ENOG4108IYU L-aspartate oxidase HV304_RS06340 ENOG4105EMN RNA polymerase sigma factor HV304_RS06345 ENOG41069PW sigma-e factor negative regulatory protein HV304_RS06350 ENOG4105VQK sigma E regulatory protein, MucB RseB HV304_RS06355 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV304_RS06365 ENOG4105C3F Signal peptidase i HV304_RS06375 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HV304_RS06385 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV304_RS06390 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HV304_RS06395 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV304_RS06400 ENOG4106G6Q Transcriptional regulator HV304_RS06405 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV304_RS06415 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV304_RS06420 ENOG4108Z6B deaminase HV304_RS06425 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV304_RS06435 ENOG4107WP9 Histidine kinase HV304_RS06440 ENOG4108SKK alpha helix protein HV304_RS06445 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV304_RS06450 ENOG4108YZA Nitrogen regulatory protein pii HV304_RS06455 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV304_RS06460 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HV304_RS06485 ENOG4105FUY alpha subunit HV304_RS06490 ENOG4108W5M transcriptional regulator HV304_RS06495 ENOG4108NZE NAGC-like transcriptional regulator HV304_RS06500 ENOG4107HQ7 repeat protein HV304_RS06505 ENOG4107QNK )-transporter HV304_RS06515 ENOG4105D8G Major Facilitator superfamily HV304_RS06520 ENOG4108MN2 Stationary phase inducible protein CsiE HV304_RS06525 ENOG4105C2X Arabinose 5-phosphate isomerase HV304_RS06530 ENOG4105EF1 ribulokinase HV304_RS06540 ENOG4105CNN ABC, transporter HV304_RS06545 ENOG4105C2J ABC transporter HV304_RS06555 ENOG41065CD Exported protein HV304_RS06560 ENOG4105D7X high-affinity nickel-transporter HV304_RS06565 ENOG4105ECY inositol monophosphatase HV304_RS06570 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HV304_RS06575 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV304_RS06580 ENOG4105C3J Cysteine desulfurase HV304_RS06585 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV304_RS06590 ENOG4108Z4V iron-sulfur cluster assembly HV304_RS06605 ENOG4108ZIT Ferredoxin, 2FE-2S HV304_RS06610 ENOG4105WVQ Fe-S assembly protein IscX HV304_RS06615 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV304_RS06620 ENOG4105YYA enhanced serine sensitivity protein SseB HV304_RS06625 ENOG4105KHC sulfurtransferase HV304_RS06630 ENOG4105DN3 alpha-2-macroglobulin domain protein HV304_RS06635 ENOG4108JQB penicillin-binding protein 1C HV304_RS06645 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HV304_RS06655 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HV304_RS06665 ENOG4105N21 Membrane HV304_RS06670 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV304_RS06675 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HV304_RS06680 ENOG4105DUX Transporter HV304_RS06690 ENOG4105VPD cellular component movement HV304_RS06715 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV304_RS06725 ENOG4105D64 Mechanosensitive ion channel HV304_RS06730 ENOG41062G3 Protein of unknown function (DUF2633) HV304_RS06735 ENOG4105BZU Histidine kinase HV304_RS06740 ENOG4105C9X ppx gppa phosphatase HV304_RS06745 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HV304_RS06750 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV304_RS06760 ENOG4105CS2 ec 3.2.1.21 HV304_RS06765 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HV304_RS06770 ENOG4105C2W permease HV304_RS06775 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV304_RS06780 ENOG4105K89 arsenate reductase HV304_RS06785 ENOG4105ERG peptidase m48, ste24p HV304_RS06790 ENOG4105C02 permease HV304_RS06795 ENOG41074DU domain protein HV304_RS06800 ENOG4108P2H Inner membrane protein YjiG HV304_RS06805 ENOG4105DYB Isoaspartyl dipeptidase HV304_RS06810 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV304_RS06815 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV304_RS06825 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV304_RS06830 ENOG4105C8V SAICAR synthetase HV304_RS06835 ENOG4105CGZ zinc metallopeptidase HV304_RS06840 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HV304_RS06845 ENOG4106KED esterase YpfH HV304_RS06855 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HV304_RS06860 ENOG4105KUZ arsenate reductase HV304_RS06870 ENOG4105BZS acriflavin resistance protein HV304_RS06875 ENOG4105BZU Histidine kinase HV304_RS06880 ENOG4105BZ8 glutamate synthase HV304_RS06890 ENOG4108PVD exported protein HV304_RS06895 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV304_RS06900 ENOG4105C6K Malic enzyme HV304_RS06905 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HV304_RS06910 ENOG4106S4J ethanolamine utilization protein EutP HV304_RS06915 ENOG4105NDK ethanolamine utilization protein HV304_RS06920 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HV304_RS06925 ENOG4108IJ2 phosphate acetyltransferase HV304_RS06930 ENOG4105KNY Microcompartments protein HV304_RS06935 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV304_RS06940 ENOG4108EKI Dehydrogenase HV304_RS06945 ENOG4107YMV ethanolamine utilization protein HV304_RS06950 ENOG4105C0A alcohol dehydrogenase HV304_RS06955 ENOG4105ENY Ethanolamine utilization protein eutH HV304_RS06960 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HV304_RS06965 ENOG4105CPD ethanolamine ammonia-lyase HV304_RS06975 ENOG4106D67 ethanolamine utilization protein HV304_RS06980 ENOG4108X49 Ethanolamine utilization protein EutK HV304_RS06985 ENOG4108K3Z AraC family transcriptional regulator HV304_RS06995 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV304_RS07000 ENOG4108R6G acetyltransferase HV304_RS07005 ENOG4105QZU Inner membrane protein YfeZ HV304_RS07010 ENOG4105E7K (LipO)protein HV304_RS07015 ENOG4105EZR dyp-type peroxidase family protein HV304_RS07020 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HV304_RS07025 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV304_RS07030 ENOG4108I5D sulfate abc transporter HV304_RS07035 ENOG4105ECW sulfate abc transporter HV304_RS07040 ENOG4108IJ6 ABC transporter HV304_RS07045 ENOG4105C6T cysteine synthase HV304_RS07050 ENOG41089BK Glutamine amido-transferase HV304_RS07055 ENOG4105CSW GntR family transcriptional regulator HV304_RS07060 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV304_RS07070 ENOG4105C5Y PTS System HV304_RS07075 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV304_RS07080 ENOG4105KZ7 phosphocarrier protein hpr HV304_RS07085 ENOG4105C6T cysteine synthase HV304_RS07090 ENOG4105EXN Sulfate transport protein CysZ HV304_RS07100 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HV304_RS07105 ENOG4105VRT cytoplasmic protein HV304_RS07110 ENOG4105DHU Bile acid HV304_RS07115 ENOG4108M0I Transcriptional regulator HV304_RS07120 ENOG4108NFH Sugar hydrolase HV304_RS07125 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HV304_RS07130 ENOG4105EAA nucleoside HV304_RS07140 ENOG4105CN8 Transcriptional regulator HV304_RS07170 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HV304_RS07175 ENOG4105GXM Putative transcription regulator (DUF1323) HV304_RS07180 ENOG4105HZG regulatoR HV304_RS07195 ENOG4105D9N nucleoside HV304_RS07200 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HV304_RS07205 ENOG4109076 Conserved Protein HV304_RS07210 ENOG4105CPC Aldo Keto reductase HV304_RS07215 ENOG4107RA9 decarboxylase HV304_RS07225 ENOG4105CHC glucokinase (EC 2.7.1.2) HV304_RS07230 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV304_RS07235 ENOG410863U PTS System HV304_RS07240 ENOG4105DC7 peptidase M24 HV304_RS07245 ENOG4105CN9 Peptidase m42 family protein HV304_RS07250 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV304_RS07265 ENOG4108CIP transcriptional regulator HV304_RS07270 ENOG4105DY9 regulatoR HV304_RS07275 ENOG4108HRK Histidine kinase HV304_RS07280 ENOG4105CHM Aminotransferase HV304_RS07295 ENOG4105D1S lipid A biosynthesis HV304_RS07300 ENOG4105F2I Transposase HV304_RS07310 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HV304_RS07320 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HV304_RS07325 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV304_RS07330 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS07375 ENOG4108UUM single-stranded DNA-binding protein HV304_RS07485 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HV304_RS07510 ENOG4105KUS lysozyme HV304_RS07515 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV304_RS07535 ENOG4108N0N Phage Terminase Large Subunit HV304_RS07555 ENOG4105DFP Integrase HV304_RS07755 ENOG4108US3 tail fiber assembly HV304_RS07760 ENOG4105PTU response to oxidative stress HV304_RS07770 ENOG4105DFP Integrase HV304_RS07780 ENOG4105S64 Formate nitrite transporter HV304_RS07785 ENOG410903C (LipO)protein HV304_RS07790 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV304_RS07795 ENOG4105KZW UPF0381 protein HV304_RS07800 ENOG4105CHU acetyl-coa acetyltransferase HV304_RS07805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV304_RS07810 ENOG4108BY2 phosphohistidine phosphatase HV304_RS07815 ENOG4108DG9 Smr protein MutS2 HV304_RS07820 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HV304_RS07830 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HV304_RS07835 ENOG4105EJ9 Membrane HV304_RS07840 ENOG4108BPE -transporting atpase HV304_RS07845 ENOG4105MH2 YfcL protein HV304_RS07850 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV304_RS07855 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV304_RS07860 ENOG4105F9N Major Facilitator Superfamily HV304_RS07865 ENOG4106WZ1 flagella biosynthesis regulator HV304_RS07870 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HV304_RS07875 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV304_RS07885 ENOG4105DQR SNARE associated Golgi HV304_RS07895 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV304_RS07900 ENOG4108S3P Sporulation domain protein HV304_RS07905 ENOG4105E96 Colicin v production protein HV304_RS07910 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV304_RS07915 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV304_RS07920 ENOG4105E89 ABC transporter HV304_RS07925 ENOG4105E89 ABC transporter HV304_RS07930 ENOG4105DSP amino acid AbC transporter HV304_RS07935 ENOG4106YG3 ABC transporter HV304_RS07940 ENOG4108JEH abc transporter atp-binding protein HV304_RS07945 ENOG4105D9U N-acetyltransferase HV304_RS07950 ENOG4105ECP epimerase HV304_RS07955 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV304_RS07960 ENOG4105CYM Glutathione S-transferase HV304_RS07965 ENOG4108SHQ Glutathione S-transferase HV304_RS07970 ENOG4108RE9 Phosphodiesterase HV304_RS07975 ENOG4105PTV Nudix Hydrolase HV304_RS07980 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV304_RS07985 ENOG4105C6K Malic enzyme HV304_RS07990 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV304_RS07995 ENOG4105PQ6 UPF0208 membrane protein HV304_RS08005 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV304_RS08010 ENOG4107QWE )-transporter HV304_RS08015 ENOG4105DK2 UPF0207 protein HV304_RS08020 ENOG4105CHM Aminotransferase HV304_RS08025 ENOG4107NQ8 LysR family Transcriptional regulator HV304_RS08035 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV304_RS08040 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV304_RS08045 ENOG4105GKE subunit e HV304_RS08050 ENOG4107QIZ NADH dehydrogenase HV304_RS08055 ENOG4108IEH NADH dehydrogenase subunit g HV304_RS08060 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HV304_RS08070 ENOG4107UFS subunit j HV304_RS08080 ENOG4105D65 subunit l HV304_RS08085 ENOG4105C8S subunit m HV304_RS08090 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV304_RS08100 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV304_RS08105 ENOG4107YB6 acetyltransferase, (GNAT) family HV304_RS08110 ENOG4105TNS Conserved Protein HV304_RS08115 ENOG4105E4F Isochorismate synthase HV304_RS08125 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HV304_RS08130 ENOG4108IPT Naphthoate synthase HV304_RS08140 ENOG4105CEY Amp-dependent synthetase and ligase HV304_RS08145 ENOG4106GZG polymyxin resistance protein B HV304_RS08190 ENOG4108UII YfaZ family HV304_RS08195 ENOG4108EWA cinA-like protein HV304_RS08200 ENOG4105DNE Transposase HV304_RS08205 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV304_RS08210 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HV304_RS08215 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV304_RS08220 ENOG4105CXY transporter HV304_RS08225 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV304_RS08230 ENOG4105XPH Ferredoxin HV304_RS08235 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV304_RS08240 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV304_RS08245 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HV304_RS08250 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV304_RS08255 ENOG4105BZU Histidine kinase HV304_RS08260 ENOG41068CG regulatoR HV304_RS08265 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV304_RS08275 ENOG4105CJ2 (LipO)protein HV304_RS08280 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV304_RS08285 ENOG4105CF1 Alkylated DNA repair protein HV304_RS08290 ENOG4105IBP Cyclic peptide transporter HV304_RS08295 ENOG4105CJW magnesium transporter HV304_RS08300 ENOG4105CHH sulfate transporter HV304_RS08305 ENOG4105DWT malate dehydrogenase (quinone) HV304_RS08315 ENOG4108ZNS ferredoxin-type protein NapF HV304_RS08320 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HV304_RS08325 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV304_RS08330 ENOG4108BGM Quinol dehydrogenase periplasmic component HV304_RS08335 ENOG4105GXZ Ferredoxin-type protein NapH HV304_RS08340 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HV304_RS08345 ENOG4105CUW cytochrome C-TYPE protein HV304_RS08350 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HV304_RS08355 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HV304_RS08360 ENOG41060IM Heme exporter protein HV304_RS08365 ENOG4105X3C heme exporter protein HV304_RS08370 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HV304_RS08375 ENOG4105DA4 cytochrome c-type biogenesis protein HV304_RS08380 ENOG4107QX9 Thiol disulfide interChange protein HV304_RS08385 ENOG4105KWW Biogenesis protein HV304_RS08390 ENOG4105WH1 Two component transcriptional regulator luxr family HV304_RS08405 ENOG4105F2I Transposase HV304_RS08455 ENOG4108R7K Metal Dependent Phosphohydrolase HV304_RS08460 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HV304_RS08465 ENOG4105H40 HV304_RS08485 ENOG4108S1U HV304_RS08495 ENOG4105CAR Terminase, large subunit HV304_RS08515 ENOG4108MXB Protein of unknown function (DUF968) HV304_RS08520 ENOG4105HGD Antitermination protein HV304_RS08540 ENOG4108YV9 Protein of unknown function (DUF2514) HV304_RS08555 ENOG4105FKG DNA packaging protein HV304_RS08560 ENOG4105UZW Tail fiber assembly protein HV304_RS08565 ENOG4107DE1 head-to-tail joining protein HV304_RS08575 ENOG4105F7J membrane-bound serine protease HV304_RS08585 ENOG4105IM0 capsid protein HV304_RS08695 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS08700 ENOG4105Y50 Virulence Protein HV304_RS08710 ENOG4105KT5 UmuD protein HV304_RS08720 ENOG4105E68 Sulfatase HV304_RS08725 ENOG4105PAN UPF0352 protein HV304_RS08730 ENOG4106V8H Nucleoid-associated protein HV304_RS08735 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HV304_RS08740 ENOG4105CFI type iii restriction protein res subunit HV304_RS08745 ENOG4105I08 Pseudouridine synthase HV304_RS08750 ENOG4105C2C drug resistance transporter, Bcr CflA HV304_RS08755 ENOG4105HG6 HV304_RS08760 ENOG4108JQ5 ABC transporter HV304_RS08765 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV304_RS08770 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV304_RS08775 ENOG4105E43 Extracellular solute-binding protein, family 5 HV304_RS08780 ENOG4105CXC rtn protein HV304_RS08785 ENOG4107TT5 NLP P60 protein HV304_RS08790 ENOG41076MN Phosphoesterase, PA-phosphatase related HV304_RS08795 ENOG4105CKI cobalamin synthesis protein HV304_RS08800 ENOG4105DEI Mannitol dehydrogenase HV304_RS08805 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HV304_RS08815 ENOG4105F2I Transposase HV304_RS08820 ENOG4105CUW cytochrome C-TYPE protein HV304_RS08825 ENOG4108EM1 reductase HV304_RS08830 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HV304_RS08835 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV304_RS08840 ENOG4105KRS Proteinase inhibitor HV304_RS08845 ENOG4105S8Q sugar efflux transporter HV304_RS08850 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV304_RS08855 ENOG4105DE4 1-phosphofructokinase HV304_RS08860 ENOG4105DM4 PTS System HV304_RS08865 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV304_RS08875 ENOG4107YNJ LysR family Transcriptional regulator HV304_RS08880 ENOG4105DD7 kinase (PfkB family HV304_RS08885 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HV304_RS08890 ENOG4105D9N nucleoside HV304_RS08895 ENOG4105DD7 kinase (PfkB family HV304_RS08905 ENOG4105HMI Membrane HV304_RS08910 ENOG4105DUM transcriptional regulator, lysR family HV304_RS08915 ENOG4108IQI permease HV304_RS08920 ENOG4105D05 Receptor HV304_RS08930 ENOG4105EUJ GTP cyclohydrolase i HV304_RS08935 ENOG4105DHF Membrane HV304_RS08940 ENOG41060NJ transcriptional regulator HV304_RS08950 ENOG4105C2J ABC transporter HV304_RS08955 ENOG4107SDZ Galactoside transport system permease protein mglC HV304_RS08960 ENOG4107SJI Dehydrogenase HV304_RS08965 ENOG4105BZ8 glutamate synthase HV304_RS08970 ENOG4105Y9N Membrane HV304_RS08975 ENOG4107GZ4 SanA protein HV304_RS08980 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HV304_RS08985 ENOG41067MG lrgb family HV304_RS08990 ENOG4105VAW lrga family HV304_RS09015 ENOG4108RXX maleylacetoacetate isomerase HV304_RS09020 ENOG4105MSY salicylate hydroxylase HV304_RS09025 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV304_RS09035 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV304_RS09040 ENOG4105KHU inner membrane protein YohD HV304_RS09045 ENOG41069YE inner membrane protein yohC HV304_RS09050 ENOG41061WM D-Alanyl-D-Alanine HV304_RS09055 ENOG4105CXG d-lactate dehydrogenase HV304_RS09060 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV304_RS09065 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV304_RS09070 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV304_RS09075 ENOG4108IJ8 ABC transporter HV304_RS09080 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV304_RS09090 ENOG4108XDN Transcriptional regulator HV304_RS09095 ENOG4108HRK Histidine kinase HV304_RS09100 ENOG4108NEV two component transcriptional regulator, LytTR family HV304_RS09105 ENOG4108W15 Protein of unknown function (DUF1456) HV304_RS09110 ENOG4108YCW (LipO)protein HV304_RS09120 ENOG4105D1F ATP-binding protein HV304_RS09135 ENOG4105F2I Transposase HV304_RS09140 ENOG4105CW0 outer membrane usher protein HV304_RS09150 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV304_RS09215 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HV304_RS09220 ENOG4105DWF phosphomethylpyrimidine kinase HV304_RS09225 ENOG4105FDP GntR family transcriptional regulator HV304_RS09230 ENOG4108TFM Kinase, PfkB family HV304_RS09235 ENOG4108KD5 ADP-ribosylation crystallin J1 HV304_RS09240 ENOG4105EAA nucleoside HV304_RS09245 ENOG4105EIE fructose-bisphosphate aldolase HV304_RS09250 ENOG4107TE5 Lipid kinase HV304_RS09255 ENOG4106TNF Periplasmic binding protein HV304_RS09260 ENOG4105DMR ABC, transporter HV304_RS09265 ENOG4105GBT ABC transporter HV304_RS09270 ENOG4106PMH Extracellular solute-binding protein family 3 HV304_RS09275 ENOG4105E5Z arginine transporter ATP-binding subunit HV304_RS09280 ENOG41064MM (LipO)protein HV304_RS09290 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV304_RS09295 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV304_RS09300 ENOG4105CGD Nad-dependent epimerase dehydratase HV304_RS09305 ENOG4105C5W Aldolase HV304_RS09310 ENOG4105C7K acetolactate synthase HV304_RS09320 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV304_RS09325 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV304_RS09335 ENOG4105DWU Membrane HV304_RS09340 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV304_RS09345 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV304_RS09350 ENOG4108MJ5 VirK protein HV304_RS09355 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV304_RS09365 ENOG4105VEQ Cold shock protein HV304_RS09370 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HV304_RS09375 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV304_RS09380 ENOG4105CFP Peptidase U32 HV304_RS09385 ENOG4105KWI UPF0339 protein HV304_RS09390 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV304_RS09395 ENOG4105EB3 Histidine kinase HV304_RS09400 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV304_RS09405 ENOG4105BZS acriflavin resistance protein HV304_RS09410 ENOG4105BZS acriflavin resistance protein HV304_RS09425 ENOG4105R8A Heat shock protein HV304_RS09430 ENOG4105D03 DNA-3-methyladenine glycosylase II HV304_RS09435 ENOG4105BZU Histidine kinase HV304_RS09445 ENOG4105DHP deoxycytidine triphosphate deaminase HV304_RS09450 ENOG4108GAE asmA family HV304_RS09455 ENOG4105EE5 Membrane protein terC HV304_RS09460 ENOG4105DAY polysaccharide export protein HV304_RS09465 ENOG4105KJF protein tyrosine phosphatase HV304_RS09470 ENOG4105D75 Capsular exopolysaccharide family HV304_RS09475 ENOG41090RK glycosyl transferase HV304_RS09480 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HV304_RS09485 ENOG4107RXY Glycosyl transferase HV304_RS09490 ENOG4108NYJ Colanic acid HV304_RS09495 ENOG4105ECJ Glycosyl Transferase HV304_RS09500 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HV304_RS09505 ENOG4105C0K Gdp-mannose 4,6-dehydratase HV304_RS09510 ENOG4105C30 Nad-dependent epimerase dehydratase HV304_RS09515 ENOG4105FGF GDP-mannose mannosyl hydrolase HV304_RS09520 ENOG4106CD9 glycosyl transferase group 1 HV304_RS09525 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV304_RS09530 ENOG4107QKV phosphomannomutase HV304_RS09535 ENOG4105D3Q Sugar transferase HV304_RS09540 ENOG4105PSV Polysaccharide Biosynthesis Protein HV304_RS09545 ENOG4105C74 pyruvyl transferase HV304_RS09550 ENOG4107T8Q Glycosyl transferase (Group 1 HV304_RS09555 ENOG4105G1A colanic acid biosynthesis protein HV304_RS09560 ENOG4105DMT epimerase dehydratase HV304_RS09565 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV304_RS09570 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV304_RS09575 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HV304_RS09585 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HV304_RS09590 ENOG4108MX3 Polysaccharide Biosynthesis Protein HV304_RS09595 ENOG410650X lipopolysaccharide core region biosynthetic process HV304_RS09605 ENOG4107S6X Glycosyl transferase, family 2 HV304_RS09610 ENOG4105CG5 Glycosyl transferase (Group 1 HV304_RS09620 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV304_RS09635 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HV304_RS09650 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HV304_RS09655 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV304_RS09660 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV304_RS09665 ENOG4105CIH Imidazole acetol-phosphate transaminase HV304_RS09670 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HV304_RS09685 ENOG4107SRH Nad-dependent epimerase dehydratase HV304_RS09690 ENOG4105EQ1 Transcriptional regulator HV304_RS09700 ENOG4105CUB amino acid HV304_RS09705 ENOG4105CJB Exodeoxyribonuclease I HV304_RS09715 ENOG4105F2I Transposase HV304_RS09725 ENOG4105QAX Iron-sulfur HV304_RS09730 ENOG4108NWD Cytochrome HV304_RS09735 ENOG4105DZ1 carboxypeptidase HV304_RS09740 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HV304_RS09745 ENOG4105DR8 Membrane HV304_RS09750 ENOG41090HJ UPF0265 protein HV304_RS09755 ENOG4105JZC GHMP kinase HV304_RS09760 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV304_RS09765 ENOG4105KTW ethanolamine utilization protein HV304_RS09770 ENOG4105M3W utilization protein HV304_RS09780 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HV304_RS09790 ENOG4108EKI Dehydrogenase HV304_RS09800 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV304_RS09810 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HV304_RS09820 ENOG4105KNY Microcompartments protein HV304_RS09830 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV304_RS09835 ENOG4108ZFT Dehydratase small subunit HV304_RS09840 ENOG4105YCI dehydratase medium subunit HV304_RS09845 ENOG4105DMB glycerol dehydratase HV304_RS09850 ENOG4105EHR propanediol utilization protein pduB HV304_RS09855 ENOG4105KNY Microcompartments protein HV304_RS09860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV304_RS09865 ENOG4107XVH Transcriptional regulator HV304_RS09870 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV304_RS09875 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HV304_RS09880 ENOG41081F0 Precorrin-8x methylmutase HV304_RS09885 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HV304_RS09890 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HV304_RS09895 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HV304_RS09900 ENOG4105CIA precorrin-4 C(11)-methyltransferase HV304_RS09905 ENOG4108P62 biosynthesis protein (CbiG) HV304_RS09910 ENOG4105E4R Precorrin-3B C17-methyltransferase HV304_RS09915 ENOG4105QUC reductase HV304_RS09920 ENOG4107PPM cobalt chelatase HV304_RS09925 ENOG4105DVK Precorrin-2 c20-methyltransferase HV304_RS09930 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV304_RS09935 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV304_RS09940 ENOG4108V4M Cobalt abc transporter HV304_RS09950 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV304_RS09955 ENOG4108YZT Adenosylcobinamide kinase HV304_RS09960 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HV304_RS09965 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HV304_RS09970 ENOG4108PXI ErfK YbiS YcfS YnhG HV304_RS09975 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV304_RS09980 ENOG4107RCV ABC transporter, permease HV304_RS10005 ENOG410814C multidrug resistance protein HV304_RS10010 ENOG4105FCK Membrane HV304_RS10015 ENOG4105EST Metal Dependent Phosphohydrolase HV304_RS10020 ENOG4105DVF Cytosine-specific methyltransferase HV304_RS10025 ENOG41090BB DNA mismatch endonuclease (vsr) HV304_RS10030 ENOG4105FDR Membrane HV304_RS10035 ENOG4105CKW Inner membrane protein yedI HV304_RS10040 ENOG4105VNZ cytoplasmic protein HV304_RS10045 ENOG4105YX3 cellular response to acidity HV304_RS10050 ENOG4105VZF DsrB protein HV304_RS10055 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HV304_RS10060 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV304_RS10065 ENOG4105VS8 Flagellar biosynthetic protein fliq HV304_RS10070 ENOG4105CN7 Flagellar biosynthetic protein FliP HV304_RS10075 ENOG4105K0P flagellar biosynthesis protein HV304_RS10080 ENOG4105DD5 Flagellar motor switch protein HV304_RS10085 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV304_RS10090 ENOG4107ZI8 flagellar basal body-associated protein flil HV304_RS10095 ENOG4105WF4 Flagellar hook-length control protein HV304_RS10100 ENOG4105GSA Flagellar export protein flij HV304_RS10105 ENOG4108JIR Flagellum-specific ATP synthase HV304_RS10110 ENOG41090PJ Flagellar assembly protein HV304_RS10115 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV304_RS10120 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HV304_RS10135 ENOG41066VF YeeE YedE family protein HV304_RS10140 ENOG4105JCU Inherit from NOG: (Lipo)protein HV304_RS10145 ENOG4105E5K Alpha-amylase HV304_RS10155 ENOG4105MQ3 flagellar protein FliS HV304_RS10160 ENOG4105DTS flagellar hook-associated HV304_RS10170 ENOG4105F2I Transposase HV304_RS10175 ENOG4105F2I Transposase HV304_RS10185 ENOG4108RWI nicotinamidase HV304_RS10190 ENOG4105HDK L-asparaginase HV304_RS10195 ENOG4105D07 Signal peptide peptidase, SppA HV304_RS10200 ENOG41069NU Nitroreductase HV304_RS10205 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HV304_RS10210 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV304_RS10215 ENOG4105D82 Glutamate dehydrogenase HV304_RS10220 ENOG4105MTM Protein of unknown function (DUF1496) HV304_RS10225 ENOG4105M6F mutator MutT protein HV304_RS10230 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV304_RS10235 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV304_RS10240 ENOG4107RM6 sulfurtransferase HV304_RS10245 ENOG4108VGW abc transporter atp-binding protein HV304_RS10250 ENOG4105CXZ ABC transporter, permease HV304_RS10255 ENOG4105VNH ABC transporter solute-binding protein HV304_RS10260 ENOG4108N5C SNARE associated Golgi protein-related protein HV304_RS10265 ENOG4108RSN SNARE associated Golgi HV304_RS10270 ENOG4105CGK Exodeoxyribonuclease III HV304_RS10275 ENOG4105C8Y Acetylornithine aminotransferase HV304_RS10285 ENOG4105C26 Dehydrogenase HV304_RS10290 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HV304_RS10295 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HV304_RS10300 ENOG4108SPG Periplasmic Protein HV304_RS10305 ENOG41090B9 response to stress HV304_RS10310 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV304_RS10315 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HV304_RS10320 ENOG4105KKI DNA-binding transcriptional activator OsmE HV304_RS10325 ENOG4105VZJ PTS System HV304_RS10330 ENOG4105CK1 PTS System HV304_RS10335 ENOG4105VCP PTS System HV304_RS10340 ENOG4105EZV Transcriptional regulator HV304_RS10345 ENOG4105F8D glycoside hydrolase family 4 HV304_RS10350 ENOG410901P UPF0249 protein HV304_RS10355 ENOG4105CH6 catalase HV304_RS10360 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HV304_RS10365 ENOG4108ETY sodium dicarboxylate symporter HV304_RS10370 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV304_RS10375 ENOG4105CHR reductase HV304_RS10380 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV304_RS10385 ENOG4107PN8 YfeABCD locus regulator HV304_RS10395 ENOG4105DE4 1-phosphofructokinase HV304_RS10400 ENOG4108NE3 Salt-induced outer membrane protein HV304_RS10415 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV304_RS10420 ENOG41082NX 50s ribosomal protein l35 HV304_RS10445 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV304_RS10455 ENOG4108V06 Glutathione peroxidase HV304_RS10460 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HV304_RS10465 ENOG4108QBX (LipO)protein HV304_RS10480 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV304_RS10485 ENOG4105EHG Permease protein HV304_RS10490 ENOG4107R4I Periplasmic binding protein HV304_RS10495 ENOG4106QJH hemin transport protein HV304_RS10500 ENOG4107ENK receptor HV304_RS10510 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV304_RS10520 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV304_RS10525 ENOG4105CEY Amp-dependent synthetase and ligase HV304_RS10530 ENOG41090P5 ferredoxin-like protein HV304_RS10535 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV304_RS10540 ENOG4105C10 Electron transfer flavoprotein HV304_RS10545 ENOG4105CV7 Electron transfer flavoprotein HV304_RS10550 ENOG4105W4W Transcriptional regulator HV304_RS10555 ENOG4105C1G acyl-Coa dehydrogenase HV304_RS10560 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HV304_RS10575 ENOG4105F2I Transposase HV304_RS10580 ENOG4105EMV Major Facilitator HV304_RS10585 ENOG4105EMV Major Facilitator HV304_RS10590 ENOG4105SUA Ydil protein HV304_RS10600 ENOG4105IPI Membrane HV304_RS10605 ENOG4105CQB FAD linked oxidase domain protein HV304_RS10610 ENOG4105KA0 thioesterase Superfamily protein HV304_RS10615 ENOG410671Z uncharacterized protein ydiH HV304_RS10625 ENOG4105EJC lysr family transcriptional regulator HV304_RS10630 ENOG4108Z4V iron-sulfur cluster assembly HV304_RS10635 ENOG4105DIW FeS assembly protein SUFB HV304_RS10640 ENOG4105C3K feS assembly ATPase SufC HV304_RS10645 ENOG4105JRK feS assembly protein SufD HV304_RS10650 ENOG4105C9B Cysteine desulfurase HV304_RS10660 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV304_RS10670 ENOG4105CA9 Pyruvate kinase HV304_RS10675 ENOG4105CUB amino acid HV304_RS10690 ENOG4108RVA ribokinase HV304_RS10700 ENOG4108UMI ABC transporter, permease HV304_RS10705 ENOG4105D01 (LipO)protein HV304_RS10720 ENOG4105DB1 molybdopterin oxidoreductase HV304_RS10725 ENOG4106WHD Tetrathionate reductase HV304_RS10730 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV304_RS10735 ENOG4106AFQ Histidine kinase HV304_RS10740 ENOG4108ZXC Two component transcriptional regulator, luxr family HV304_RS10745 ENOG4105RFR Protein of unknown function (DUF2767) HV304_RS10750 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HV304_RS10755 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HV304_RS10760 ENOG4105JVW HV304_RS10765 ENOG4108393 oxidoreductase Fe-S subunit HV304_RS10770 ENOG4108NWD Cytochrome HV304_RS10775 ENOG4108Y7C Conserved Protein HV304_RS10780 ENOG4105DRP amino acid AbC transporter HV304_RS10785 ENOG4106YG3 ABC transporter HV304_RS10795 ENOG4105CT1 (ABC) transporter HV304_RS10805 ENOG4105C85 amino acid HV304_RS10820 ENOG4105C26 Dehydrogenase HV304_RS10845 ENOG4108JPW Aminotransferase HV304_RS10850 ENOG4105S10 periplasmic binding protein HV304_RS10855 ENOG4105EHG Permease protein HV304_RS10860 ENOG4108W0P ABC transporter HV304_RS10865 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HV304_RS10905 ENOG4105E6S usher protein( HV304_RS10910 ENOG4108S1B Periplasmic chaperone protein HV304_RS10925 ENOG4105D29 Helix-turn-helix type 11 domain protein HV304_RS10930 ENOG4105CHR reductase HV304_RS10945 ENOG4105F4G Membrane HV304_RS10950 ENOG4108V06 Glutathione peroxidase HV304_RS10955 ENOG4105BZU Histidine kinase HV304_RS10975 ENOG4105KME endoribonuclease L-psp HV304_RS10980 ENOG4105N0V mono-oxygenase ydhR HV304_RS10985 ENOG4105JAB phenazine biosynthesis protein, phzf family HV304_RS10990 ENOG4105D3G Pseudouridine synthase HV304_RS11000 ENOG4108R6K riboflavin synthase, subunit alpha HV304_RS11005 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV304_RS11010 ENOG4105CZQ inner membrane transport protein YdhC HV304_RS11015 ENOG4105F52 Transcriptional regulator HV304_RS11020 ENOG4105ETE Transcriptional regulator (LacI family HV304_RS11030 ENOG4105F27 Major Facilitator HV304_RS11035 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV304_RS11040 ENOG4105K4H Nlp p60 protein HV304_RS11045 ENOG4105M2J Glutaredoxin HV304_RS11050 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV304_RS11055 ENOG4108UYE Lactoylglutathione lyase HV304_RS11060 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV304_RS11065 ENOG4108WUH Transcriptional regulator, TetR family HV304_RS11070 ENOG4105XZD Fe-S protein HV304_RS11075 ENOG4107RGM aldo keto reductase HV304_RS11080 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV304_RS11085 ENOG4105DSW Fusaric acid resistance protein HV304_RS11090 ENOG4105Y49 secretion protein, HlyD family HV304_RS11105 ENOG4108XTF Outer Membrane Lipoprotein HV304_RS11115 ENOG410642K Lysozyme inhibitor HV304_RS11125 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HV304_RS11130 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV304_RS11135 ENOG4108K3A Glutathione S-transferase HV304_RS11140 ENOG4105DUX Transporter HV304_RS11145 ENOG4105CSM endonuclease III HV304_RS11150 ENOG4105DZB Electron transport complex HV304_RS11155 ENOG4108UQQ Electron transport complex HV304_RS11160 ENOG4105D6A Electron transport complex HV304_RS11170 ENOG4108R3D Electron transport complex HV304_RS11180 ENOG4105M9B inner membrane protein ydgK HV304_RS11185 ENOG4105QZ5 OriC-binding nucleoid-associated protein HV304_RS11190 ENOG4106C6R beta-lactam resistance protein HV304_RS11195 ENOG4105D9R oxidoreductase HV304_RS11205 ENOG4105C87 Aminotransferase class I and II HV304_RS11210 ENOG4105CI1 PTS System HV304_RS11215 ENOG4107P2S Transcriptional regulator HV304_RS11220 ENOG4106J39 exported protein HV304_RS11225 ENOG4105EIP mannose-6-phosphate isomerase HV304_RS11230 ENOG4107GFK fumarate HV304_RS11235 ENOG4105C9Q fumarate hydratase class II HV304_RS11240 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HV304_RS11245 ENOG4105JJR Histidine kinase HV304_RS11275 ENOG4108ETY sodium dicarboxylate symporter HV304_RS11280 ENOG4107EXC regulatoR HV304_RS11285 ENOG4105RA2 Membrane HV304_RS11290 ENOG410642E Short chain dehydrogenase HV304_RS11295 ENOG4105D5Q Arginine ornithine antiporter HV304_RS11300 ENOG4105C5D exported protein HV304_RS11305 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV304_RS11310 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV304_RS11315 ENOG4105DSF transport protein HV304_RS11325 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HV304_RS11330 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV304_RS11340 ENOG4105CTD carboxy-peptidase HV304_RS11355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV304_RS11360 ENOG4105I8F Histidine kinase HV304_RS11370 ENOG4105D94 Major Facilitator Superfamily HV304_RS11375 ENOG4106NZI LysR family Transcriptional regulator HV304_RS11380 ENOG4105DAG ROK family HV304_RS11385 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV304_RS11390 ENOG4105CMQ Chloride channel HV304_RS11395 ENOG4108NEM leader-binding protein dmsD HV304_RS11400 ENOG4107KGK dmso reductase anchor subunit HV304_RS11405 ENOG4105QAX Iron-sulfur HV304_RS11415 ENOG4105KBG Protein of unknown function (DUF1161) HV304_RS11425 ENOG4108MK9 spermidine N(1)-acetyltransferase HV304_RS11430 ENOG4105M5Q UPF0482 protein HV304_RS11435 ENOG4105KK4 UPF0060 membrane protein HV304_RS11440 ENOG4105CXK mandelate racemase muconate lactonizing HV304_RS11450 ENOG4105DEI Mannitol dehydrogenase HV304_RS11455 ENOG41061EV selenium-binding protein YdfZ HV304_RS11460 ENOG4107XBN GntR Family Transcriptional Regulator HV304_RS11465 ENOG4105EMU Dehydrogenase HV304_RS11470 ENOG4105DGW oligopeptidase A HV304_RS11480 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HV304_RS11495 ENOG4105C32 Amino acid ABC transporter (Permease) HV304_RS11500 ENOG4105CNN ABC, transporter HV304_RS11505 ENOG4105C2J ABC transporter HV304_RS11510 ENOG4108IV0 ABC, transporter HV304_RS11515 ENOG4105E5W Transporter HV304_RS11520 ENOG4108594 Permease of the drug metabolite transporter HV304_RS11525 ENOG4106DNR multiple antibiotic resistance protein HV304_RS11530 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV304_RS11535 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV304_RS11545 ENOG4105F27 Major Facilitator HV304_RS11550 ENOG4105EGI Transcriptional regulator HV304_RS11555 ENOG4105C26 Dehydrogenase HV304_RS11560 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS11565 ENOG4105CSV Glutaminase HV304_RS11570 ENOG4105M0C cytoplasmic protein HV304_RS11585 ENOG4105FFC UPF0187 protein HV304_RS11600 ENOG4108428 Inherit from COG: -acetyltransferase HV304_RS11625 ENOG4105GQR Chaperone HV304_RS11645 ENOG4108JJ6 Type I secretion system ATPase HV304_RS11650 ENOG4107QZV Type I secretion membrane fusion protein HV304_RS11655 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HV304_RS11660 ENOG4105F32 YngK protein HV304_RS11685 ENOG4105XXV Acid-resistance protein HV304_RS11695 ENOG4108UQS dipeptidase HV304_RS11700 ENOG4105DEF Extracellular solute-binding protein, family 5 HV304_RS11705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV304_RS11710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV304_RS11715 ENOG4105C3U ABC transporter HV304_RS11720 ENOG4107H6U ABC transporter HV304_RS11725 ENOG4105DUM transcriptional regulator, lysR family HV304_RS11730 ENOG4107QP7 CoA-transferase subunit A HV304_RS11735 ENOG4107QNJ CoA-transferase subunit B HV304_RS11740 ENOG4105CHU acetyl-coa acetyltransferase HV304_RS11745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV304_RS11750 ENOG4105CY2 Citrate transporter HV304_RS11755 ENOG4105DTD Dehydrogenase HV304_RS11760 ENOG4108Z9K Osmotically inducible protein HV304_RS11765 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HV304_RS11770 ENOG4107R1I NAD-dependent malic enzyme HV304_RS11775 ENOG4105C5H ABC transporter HV304_RS11780 ENOG4105F0N pyrophosphate phospho-hydrolase HV304_RS11785 ENOG4108MG3 formate dehydrogenase HV304_RS11790 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV304_RS11800 ENOG4105RPH Inner membrane protein YddG HV304_RS11825 ENOG4107QND Nitrite extrusion protein HV304_RS11830 ENOG4105CRU nitrate reductase, alpha subunit HV304_RS11835 ENOG4108IUE nitrate reductase beta subunit HV304_RS11840 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HV304_RS11845 ENOG4105D0D Nitrate reductase 2, gamma subunit HV304_RS11850 ENOG4105JAB phenazine biosynthesis protein, phzf family HV304_RS11865 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV304_RS11870 ENOG4108MEJ flavin reductase domain protein HV304_RS11895 ENOG4108N27 Glutathione S-transferase HV304_RS11900 ENOG4105CC0 LysR family Transcriptional regulator HV304_RS11910 ENOG4105CDA abc transporter atp-binding protein HV304_RS11935 ENOG4105DEN Luciferase family HV304_RS11940 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV304_RS11945 ENOG4105C85 amino acid HV304_RS11950 ENOG4105SUV lipoprotein YgdR HV304_RS11955 ENOG4108NS2 receptor HV304_RS11960 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV304_RS11970 ENOG4108Z7F N-acetyltransferase HV304_RS11975 ENOG4108T9Y Inner membrane protein ydcZ HV304_RS11980 ENOG4105R71 cytoplasmic protein HV304_RS11985 ENOG4105DEF Extracellular solute-binding protein, family 5 HV304_RS12005 ENOG410654E Membrane HV304_RS12015 ENOG4105R1U AraC Family Transcriptional Regulator HV304_RS12020 ENOG4105C2C drug resistance transporter, Bcr CflA HV304_RS12025 ENOG4105C26 Dehydrogenase HV304_RS12030 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HV304_RS12035 ENOG4105D81 ABC transporter, permease HV304_RS12040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV304_RS12045 ENOG4107TYH extracellular solute-binding protein family 1 HV304_RS12050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV304_RS12055 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HV304_RS12065 ENOG4105C4M (Ubiquinol oxidase) subunit I HV304_RS12070 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV304_RS12085 ENOG4105CFP Peptidase U32 HV304_RS12090 ENOG4108JCI Transcriptional regulator HV304_RS12095 ENOG4105DKK Benzoate HV304_RS12115 ENOG41088CC tellurite resistance protein tehB HV304_RS12120 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HV304_RS12125 ENOG4107WE3 acetyltransferase YdcK HV304_RS12130 ENOG4108Z9I -acetyltransferase HV304_RS12135 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV304_RS12140 ENOG4105Z2P Protein of unknown function (DUF465) HV304_RS12150 ENOG4105E32 cytoplasmic protein HV304_RS12155 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HV304_RS12160 ENOG4105DDW LysR family Transcriptional regulator HV304_RS12170 ENOG4108VEV chaperone HV304_RS12175 ENOG4105CW0 outer membrane usher protein HV304_RS12195 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS12235 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV304_RS12240 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV304_RS12245 ENOG4108MG3 formate dehydrogenase HV304_RS12250 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV304_RS12255 ENOG4105KT5 UmuD protein HV304_RS12260 ENOG4105CPW cytochrome b561 HV304_RS12265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV304_RS12275 ENOG4105C26 Dehydrogenase HV304_RS12280 ENOG4107DB1 DUF218 domain HV304_RS12285 ENOG4105CQ7 ATP-dependent helicase HV304_RS12290 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HV304_RS12300 ENOG4105WXT Conserved Protein HV304_RS12305 ENOG410689M (LipO)protein HV304_RS12310 ENOG4107H52 Dicarboxylate transport HV304_RS12315 ENOG4105C5I Dehydrogenase HV304_RS12320 ENOG41090X5 Heat shock protein hslJ HV304_RS12325 ENOG4105IKK cytoplasmic protein HV304_RS12330 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV304_RS12335 ENOG4105FCK Membrane HV304_RS12345 ENOG4108RW8 Universal stress protein F HV304_RS12350 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HV304_RS12355 ENOG4105C1J atp-dependent rna helicase HV304_RS12365 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS12370 ENOG4105F2I Transposase HV304_RS12375 ENOG4105BZU Histidine kinase HV304_RS12380 ENOG4105BZU Histidine kinase HV304_RS12390 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS12400 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV304_RS12405 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV304_RS12410 ENOG4105Q9Y Universal stress protein HV304_RS12415 ENOG4105S5I Membrane HV304_RS12420 ENOG4105D64 Mechanosensitive ion channel HV304_RS12430 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HV304_RS12435 ENOG4105MVE transcriptional regulator HV304_RS12455 ENOG4107QSI ABC, transporter HV304_RS12460 ENOG4105KXI murein peptide amidase A HV304_RS12465 ENOG4107S8C mandelate racemase muconate lactonizing HV304_RS12470 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV304_RS12480 ENOG4106K28 UPF0283 membrane protein HV304_RS12485 ENOG4105CM6 amino acid regulated cytosolic protein HV304_RS12495 ENOG4105K8Z Phage shock protein HV304_RS12500 ENOG4105FKQ transcriptional regulator HV304_RS12505 ENOG4107EFV Outer membrane protein G HV304_RS12510 ENOG4108IJ9 (ABC) transporter HV304_RS12515 ENOG4107URF beta-phospho-glucomutase HV304_RS12520 ENOG4105C71 hydrolase family 65, central catalytic HV304_RS12525 ENOG4105CK5 oxidoreductase HV304_RS12530 ENOG4107TYA transient receptor potential locus HV304_RS12535 ENOG4107RRD Dehydrogenase HV304_RS12540 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HV304_RS12545 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HV304_RS12555 ENOG4107QW3 Sucrose phosphorylase HV304_RS12560 ENOG4105NNG Peripheral inner membrane phage-shock protein HV304_RS12565 ENOG4105FM1 phage shock protein C HV304_RS12570 ENOG4105YYT phage shock protein B HV304_RS12575 ENOG41087YS Phage shock protein A HV304_RS12580 ENOG4105E51 psp operon transcriptional activator HV304_RS12595 ENOG4108J59 Extracellular solute-binding protein, family 5 HV304_RS12600 ENOG4108EKA peptide transport system, permease HV304_RS12605 ENOG4108EU3 peptide transport system, permease HV304_RS12610 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV304_RS12615 ENOG4108JQ2 peptide transport system atp-binding protein HV304_RS12625 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV304_RS12630 ENOG4105Q4T oxidoreductase HV304_RS12640 ENOG4105BZU Histidine kinase HV304_RS12645 ENOG410643D UPF0509 protein HV304_RS12650 ENOG4105N2W Transcriptional regulator HV304_RS12660 ENOG4108ZJT translation initiation factor, Sui1 HV304_RS12670 ENOG4105CFV Tetratricopeptide repeat protein HV304_RS12675 ENOG4105Q4A inner membrane protein yciS HV304_RS12680 ENOG4105EYK Phosphatidylglycerophosphatase B HV304_RS12685 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HV304_RS12690 ENOG4107QM5 aconitate hydratase HV304_RS12705 ENOG4107R11 Transcriptional regulator HV304_RS12710 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV304_RS12715 ENOG4105RKX Protein of unknown function (DUF2498) HV304_RS12720 ENOG4105ERU peptidase HV304_RS12725 ENOG4105UBK short-chain dehydrogenase reductase HV304_RS12730 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV304_RS12735 ENOG4105FE9 pseudouridine synthase HV304_RS12740 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV304_RS12745 ENOG4105DB7 PHP domain protein HV304_RS12750 ENOG4105CRQ synthase (Component I) HV304_RS12755 ENOG4108EFP Anthranilate synthase component II HV304_RS12760 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV304_RS12765 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HV304_RS12770 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HV304_RS12775 ENOG4105BZU Histidine kinase HV304_RS12790 ENOG4105CDY transcriptional regulatory protein HV304_RS12795 ENOG4105EIF outer membrane protein W HV304_RS12800 ENOG4108S3I UPF0259 membrane protein HV304_RS12805 ENOG4107835 probably involved in intracellular septation (By similarity) HV304_RS12810 ENOG4105NAU thioesterase Superfamily protein HV304_RS12815 ENOG410822N TonB family HV304_RS12820 ENOG4105K9H YciI-like protein HV304_RS12830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HV304_RS12840 ENOG4105EYW Ion transport protein HV304_RS12845 ENOG4108JQ7 (ABC) transporter HV304_RS12850 ENOG4105C3U ABC transporter HV304_RS12855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV304_RS12860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV304_RS12865 ENOG4107QSI ABC, transporter HV304_RS12870 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV304_RS12875 ENOG4105C0A alcohol dehydrogenase HV304_RS12880 ENOG4107104 thymidine kinase HV304_RS12890 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV304_RS12895 ENOG4105I93 response regulator HV304_RS12900 ENOG4105D78 K07001 NTE family protein HV304_RS12910 ENOG4105CIY formyltetrahydrofolate deformylase HV304_RS12935 ENOG41076YT nitrate reductase, gamma subunit HV304_RS12940 ENOG4105R3A Nitrate reductase HV304_RS12945 ENOG4108IUE nitrate reductase beta subunit HV304_RS12950 ENOG4105CRU nitrate reductase, alpha subunit HV304_RS12955 ENOG4105DQQ Major facilitator superfamily MFS_1 HV304_RS12960 ENOG4105BZU Histidine kinase HV304_RS12965 ENOG4105WH1 Two component transcriptional regulator luxr family HV304_RS12970 ENOG4105ID0 Putative invasin HV304_RS12975 ENOG41090EX DsrE family HV304_RS12985 ENOG4108NH8 Cation transport protein HV304_RS12990 ENOG4105EWV Sodium calcium exchanger membrane region HV304_RS13000 ENOG41063JG Transcriptional regulator HV304_RS13005 ENOG4108YY7 Invasion gene expression up-regulator SirB HV304_RS13010 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HV304_RS13015 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HV304_RS13020 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HV304_RS13025 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HV304_RS13035 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV304_RS13040 ENOG4105CHH sulfate transporter HV304_RS13045 ENOG4105DY8 decarboxylase HV304_RS13050 ENOG4108JPW Aminotransferase HV304_RS13055 ENOG4105CFH Aspartokinase HV304_RS13060 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV304_RS13070 ENOG4105C3G gtp-binding protein HV304_RS13075 ENOG4106NDP Transcriptional regulator HV304_RS13080 ENOG4108HKT sucrose-6-phosphate hydrolase HV304_RS13085 ENOG4105D7K pfkb domain protein HV304_RS13090 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV304_RS13100 ENOG4105F2I Transposase HV304_RS13115 ENOG4105D82 Glutamate dehydrogenase HV304_RS13120 ENOG4105CMT Dihydroxyacetone kinase HV304_RS13125 ENOG4108UTZ Dihydroxyacetone kinase HV304_RS13135 ENOG4105E53 ec 3.2.1.28 HV304_RS13140 ENOG4105S10 periplasmic binding protein HV304_RS13145 ENOG4105EHG Permease protein HV304_RS13150 ENOG4105E0A ABC, transporter HV304_RS13155 ENOG4108BSC Methyltransferase HV304_RS13160 ENOG4108PQF modD protein HV304_RS13175 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HV304_RS13185 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV304_RS13195 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV304_RS13200 ENOG4105MWK D-amino acid dehydrogenase, small subunit HV304_RS13205 ENOG4105ED1 spovr family HV304_RS13220 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV304_RS13230 ENOG4108ZZ3 UPF0260 protein HV304_RS13235 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV304_RS13240 ENOG4105VNG YcgL domain-containing protein HV304_RS13250 ENOG4107QMS site-determining protein HV304_RS13260 ENOG4105EJC lysr family transcriptional regulator HV304_RS13265 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV304_RS13270 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV304_RS13275 ENOG4105CEY Amp-dependent synthetase and ligase HV304_RS13280 ENOG4105Y4Z Outer Membrane Lipoprotein HV304_RS13285 ENOG41072GX Peptidase M22 Glycoprotease HV304_RS13290 ENOG4105DVT helicase HV304_RS13295 ENOG4105M4H endoribonuclease L-psp HV304_RS13305 ENOG4105CRQ synthase (Component I) HV304_RS13315 ENOG4105EJQ L-serine dehydratase HV304_RS13320 ENOG4107XTP (EAL) domain protein HV304_RS13325 ENOG4105EE5 Membrane protein terC HV304_RS13330 ENOG4105DAS pts system HV304_RS13335 ENOG4105ETZ PTS System HV304_RS13340 ENOG4105F3R pts system mannose fructose sorbose family iid HV304_RS13345 ENOG4108NK4 UPF0266 membrane protein HV304_RS13355 ENOG4105DHI Methyltransferase HV304_RS13360 ENOG4105CJN penicillin-binding protein HV304_RS13375 ENOG4105Q3Y exported protein HV304_RS13380 ENOG4107BVS HV304_RS13385 ENOG4105TIK HV304_RS13390 ENOG4105J4Q Transcriptional regulator HV304_RS13395 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV304_RS13405 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HV304_RS13410 ENOG4105F2I Transposase HV304_RS13435 ENOG4108JIR Flagellum-specific ATP synthase HV304_RS13440 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone HV304_RS13475 ENOG4105Y7Q type iii secretion HV304_RS13480 ENOG4106BTR HV304_RS13485 ENOG4108RBT type iii secretion HV304_RS13520 ENOG4105D0M Protease HtpX homolog HV304_RS13525 ENOG4105CN1 protease HV304_RS13530 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HV304_RS13535 ENOG4108ZGC gaf domain protein HV304_RS13540 ENOG4105H2K paraquat-inducible protein a HV304_RS13545 ENOG4105DY2 Paraquat-inducible protein b HV304_RS13550 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HV304_RS13555 ENOG4105WT8 Protein of unknown function (DUF1480) HV304_RS13560 ENOG4105UVW uncharacterized protein yebW HV304_RS13565 ENOG4108R1E Serine threonine protein phosphatase 1 HV304_RS13570 ENOG4105NKT exported protein HV304_RS13575 ENOG4108PNC copper resistance HV304_RS13580 ENOG4105FXM Copper resistance protein HV304_RS13585 ENOG4105MPK DNA polymerase III subunit theta HV304_RS13605 ENOG4105CVR type I restriction-modification system HV304_RS13610 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV304_RS13615 ENOG4105UMD exodeoxyribonuclease X HV304_RS13620 ENOG4105CUG Oligopeptidase b HV304_RS13625 ENOG4108Q2J Inner membrane protein YebE HV304_RS13635 ENOG4105X2V dna damage-inducible protein HV304_RS13640 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HV304_RS13645 ENOG4108UHU Aldolase HV304_RS13650 ENOG4105C01 Dihydroxy-acid dehydratase HV304_RS13655 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV304_RS13660 ENOG4106KNT transcriptional regulator HV304_RS13665 ENOG4105CA9 Pyruvate kinase HV304_RS13670 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV304_RS13675 ENOG4105DR5 peptidase HV304_RS13680 ENOG4105NXV High-affinity zinc uptake system protein HV304_RS13690 ENOG4105FAV ABC, transporter HV304_RS13705 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HV304_RS13710 ENOG4105CDY transcriptional regulatory protein HV304_RS13715 ENOG4108TIT dATP pyrophosphohydrolase HV304_RS13720 ENOG4105C9M aspartyl-trna synthetase HV304_RS13725 ENOG4105D3W isochorismatase HV304_RS13730 ENOG41081XQ Conserved Protein HV304_RS13735 ENOG4105WJG Glutathione HV304_RS13745 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HV304_RS13755 ENOG4106ZCM YecM protein HV304_RS13770 ENOG4105F5H Glycosyl Hydrolase Family 88 HV304_RS13775 ENOG4105IRD Flagellar protein FlhE HV304_RS13780 ENOG4105D7B Flagellar biosynthesis protein flha HV304_RS13785 ENOG4105D00 flagellar biosynthetic protein flhB HV304_RS13790 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HV304_RS13795 ENOG4108VYJ response regulator receiver protein HV304_RS13800 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HV304_RS13805 ENOG4105BZU Histidine kinase HV304_RS13810 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS13815 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS13820 ENOG4107QJT sodium dicarboxylate symporter HV304_RS13830 ENOG4108V3W Chemotaxis protein, CheW HV304_RS13835 ENOG4105CBS Chea signal transduction histidine kinase HV304_RS13840 ENOG4105ER2 Ompa motb domain protein HV304_RS13845 ENOG4107RD7 Flagellar Motor Protein, MotA HV304_RS13850 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HV304_RS13860 ENOG4108VA4 Universal stress protein HV304_RS13865 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HV304_RS13870 ENOG4108K4C ec 3.1.3.12 HV304_RS13875 ENOG4105CNN ABC, transporter HV304_RS13880 ENOG4105C2J ABC transporter HV304_RS13885 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV304_RS13895 ENOG4108UEC Ferritin-like protein HV304_RS13900 ENOG4105N4N Protein of unknown function (DUF2766) HV304_RS13905 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV304_RS13915 ENOG4105P23 (LipO)protein HV304_RS13920 ENOG41090A1 ferritin HV304_RS13925 ENOG4105VVZ metal-binding protein HV304_RS13930 ENOG4105E0U tyrosine-specific transport protein HV304_RS13935 ENOG4106RHG Yeca family HV304_RS13940 ENOG410681U heavy metal transport detoxification protein HV304_RS13950 ENOG4108KS2 transglutaminase domain protein HV304_RS14010 ENOG4105DZR Type I site-specific deoxyribonuclease HV304_RS14020 ENOG4106RHG Yeca family HV304_RS14130 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HV304_RS14135 ENOG4105WH1 Two component transcriptional regulator luxr family HV304_RS14140 ENOG4105XVG cytoplasmic protein HV304_RS14145 ENOG4105VJY transcriptional regulator HV304_RS14150 ENOG4105CDA abc transporter atp-binding protein HV304_RS14155 ENOG4105E5Q amino acid AbC transporter HV304_RS14160 ENOG4105K6H D-cysteine desulfhydrase HV304_RS14165 ENOG4105EAB amino acid AbC transporter HV304_RS14170 ENOG4108M9K flagella biosynthesis protein FliZ HV304_RS14175 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV304_RS14185 ENOG4105F2I Transposase HV304_RS14190 ENOG4105F2I Transposase HV304_RS14200 ENOG4105E98 transcriptional regulator DeoR family HV304_RS14205 ENOG4105CPC Aldo Keto reductase HV304_RS14210 ENOG4107UH8 sugar kinase HV304_RS14215 ENOG4105D2N Aldolase HV304_RS14220 ENOG4105CPQ Dehydrogenase HV304_RS14225 ENOG4107TE1 transport protein HV304_RS14230 ENOG4105CPQ Dehydrogenase HV304_RS14240 ENOG4105N1F Hnh endonuclease HV304_RS14245 ENOG4105VUT cytoplasmic protein HV304_RS14255 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV304_RS14260 ENOG4105DSB aldose 1-epimerase HV304_RS14265 ENOG4105CV8 reductase HV304_RS14270 ENOG4105GNX MltA-interacting MipA family protein HV304_RS14275 ENOG4105CYN Serine protein kinase HV304_RS14285 ENOG4105DVA methyltransferase HV304_RS14290 ENOG4108KHP Diguanylate cyclase HV304_RS14295 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV304_RS14305 ENOG4105R1U AraC Family Transcriptional Regulator HV304_RS14310 ENOG4105DJ2 Major Facilitator Superfamily HV304_RS14315 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV304_RS14320 ENOG4105K78 MarR family Transcriptional regulator HV304_RS14325 ENOG4105UCG Domain of unknown function (DUF333) HV304_RS14330 ENOG410620I Diguanylate cyclase HV304_RS14335 ENOG4106G4W HV304_RS14345 ENOG4105Y3U Transglycosylase-associated protein HV304_RS14350 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV304_RS14360 ENOG4105YP6 Domain of unknown function (DUF1869) HV304_RS14365 ENOG4108YS1 cytoplasmic protein HV304_RS14370 ENOG4108NIW Leucine export protein LeuE HV304_RS14375 ENOG4108MEK Metal-binding protein YodA HV304_RS14380 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV304_RS14390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV304_RS14400 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HV304_RS14405 ENOG4105D05 Receptor HV304_RS14410 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HV304_RS14420 ENOG4105BZU Histidine kinase HV304_RS14450 ENOG4108HMX isocitrate dehydrogenase (NADP) HV304_RS14470 ENOG4105CAU Arsenical resistance protein, ArsH HV304_RS14480 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS14490 ENOG4105Y50 Virulence Protein HV304_RS14500 ENOG4108HMX isocitrate dehydrogenase (NADP) HV304_RS14505 ENOG4108R99 pseudouridine synthase HV304_RS14520 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HV304_RS14530 ENOG4107QTF adenylosuccinate lyase HV304_RS14535 ENOG4108RAV Conserved protein HV304_RS14545 ENOG4107SEY Conserved Protein HV304_RS14565 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV304_RS14580 ENOG4107FW0 short-chain dehydrogenase reductase HV304_RS14590 ENOG4108XDN Transcriptional regulator HV304_RS14675 ENOG4105D07 Signal peptide peptidase, SppA HV304_RS14690 ENOG4105CAR Terminase, large subunit HV304_RS14705 ENOG4108VKM cytochrome b561 HV304_RS14710 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV304_RS14715 ENOG4106IAW HV304_RS14745 ENOG4108YV9 Protein of unknown function (DUF2514) HV304_RS14775 ENOG4108MXB Protein of unknown function (DUF968) HV304_RS14780 ENOG4105QBX endodeoxyribonuclease RusA HV304_RS14865 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV304_RS14870 ENOG41076J9 exonuclease VIII HV304_RS14875 ENOG4107160 Rac prophage HV304_RS14880 ENOG4107R08 Integrase HV304_RS14885 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV304_RS14895 ENOG4105EZE Cupin 4 family protein HV304_RS14900 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV304_RS14915 ENOG4105D38 putrescine abc transporter HV304_RS14920 ENOG4108HM4 ABC transporter HV304_RS14925 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV304_RS14930 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HV304_RS14935 ENOG4105D60 lipoprotein releasing system transmembrane protein HV304_RS14940 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV304_RS14945 ENOG4105D60 lipoprotein releasing system transmembrane protein HV304_RS14950 ENOG4105IQC Inner membrane protein YcfT HV304_RS14955 ENOG4108JA2 transcriptioN-repair coupling factor HV304_RS14960 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV304_RS14965 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV304_RS14970 ENOG4108IND Tetr family transcriptional regulator HV304_RS14980 ENOG4107MBR 17 kDa surface antigen HV304_RS14985 ENOG4105CEP NADH dehydrogenase HV304_RS15005 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV304_RS15010 ENOG41090DQ Lipoprotein HV304_RS15015 ENOG4105K59 histidine triad (HIT) protein HV304_RS15025 ENOG4105F2I Transposase HV304_RS15040 ENOG4105C45 hydrogenase expression formation protein (HypE) HV304_RS15050 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HV304_RS15055 ENOG4106UW1 Major Facilitator superfamily HV304_RS15065 ENOG4105UQX Mate efflux family protein HV304_RS15075 ENOG4107R11 Transcriptional regulator HV304_RS15100 ENOG4105F2I Transposase HV304_RS15105 ENOG4108SF5 RNA Polymerase HV304_RS15110 ENOG4108S3W Anti-feci sigma factor, fecr HV304_RS15120 ENOG4108HUF Transporter HV304_RS15125 ENOG4105DQ5 transport system permease protein HV304_RS15130 ENOG4108IHU transport system permease protein HV304_RS15135 ENOG4105E0A ABC, transporter HV304_RS15145 ENOG4105CVJ phosphoglycerate mutase HV304_RS15160 ENOG4105CSH Transporter HV304_RS15165 ENOG4105FYV Amp nucleosidase HV304_RS15175 ENOG4105CI1 PTS System HV304_RS15180 ENOG4105F8V Hydrolase, tatD family HV304_RS15185 ENOG4107QRG dna polymerase iii HV304_RS15190 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HV304_RS15195 ENOG4105HHA aminodeoxychorismate lyase HV304_RS15200 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV304_RS15205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV304_RS15210 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV304_RS15215 ENOG4105CHR reductase HV304_RS15220 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV304_RS15225 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV304_RS15230 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HV304_RS15235 ENOG4105VGS 50s ribosomal protein l32 HV304_RS15240 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV304_RS15250 ENOG4105EI2 Pseudouridine synthase HV304_RS15255 ENOG4107QQB Ribonuclease E HV304_RS15260 ENOG4105EJC lysr family transcriptional regulator HV304_RS15265 ENOG4105EQ0 Major Facilitator superfamily HV304_RS15270 ENOG4105DTJ flagellar hook-associated protein HV304_RS15275 ENOG4105E1Q flagellar hook-associated protein HV304_RS15280 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV304_RS15285 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HV304_RS15295 ENOG4105CGA flagellar basal-body rod protein FlgG HV304_RS15300 ENOG4108KPB Flagellar basal-body rod protein FlgF HV304_RS15305 ENOG4105BZE flagellar hook protein, FlgE HV304_RS15310 ENOG4105W00 Flagellar hook capping protein HV304_RS15315 ENOG4108ZC9 flagellar basal-body rod protein flgc HV304_RS15320 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HV304_RS15325 ENOG4105CKS Flagella basal body P-ring formation protein flgA HV304_RS15330 ENOG4105M9M anti-sigma28 factor FlgM HV304_RS15335 ENOG4105QVD Flagella synthesis protein FlgN HV304_RS15340 ENOG4105CJR Integral membrane protein (MviN HV304_RS15345 ENOG4105EP9 oxidoreductase HV304_RS15350 ENOG4108YXG UPF0502 protein HV304_RS15355 ENOG4105D9U N-acetyltransferase HV304_RS15360 ENOG4105EV4 Multidrug resistance protein mdtH HV304_RS15365 ENOG4105F3T (LipO)protein HV304_RS15370 ENOG4105EKE dihydroorotase HV304_RS15375 ENOG4105MEA DNA damage-inducible protein i HV304_RS15380 ENOG4105PVA Biofilm formation regulatory protein BssS HV304_RS15385 ENOG4105F76 Sarcosine oxidase HV304_RS15390 ENOG4106974 biofilm formation HV304_RS15395 ENOG4105DS1 cytochrome b561 HV304_RS15400 ENOG4108YYC ycei family HV304_RS15410 ENOG4105D1S lipid A biosynthesis HV304_RS15415 ENOG4105C6X Major Facilitator HV304_RS15420 ENOG4106KTS Inner membrane protein yeaI HV304_RS15425 ENOG4108W47 Acidic protein msyB HV304_RS15430 ENOG4105NAC (LipO)protein HV304_RS15435 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HV304_RS15450 ENOG4107RZC phospholipase d HV304_RS15455 ENOG4108UVJ appr-1-p processing domain protein HV304_RS15460 ENOG41068SS HV304_RS15465 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HV304_RS15470 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HV304_RS15475 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HV304_RS15480 ENOG41086KC Transcriptional regulator HV304_RS15485 ENOG4108XDW curli assembly protein CsgE HV304_RS15490 ENOG4108WYR Curli production assembly transport component, CsgF HV304_RS15495 ENOG4105P8Q Curli production assembly transport component CsgG HV304_RS15500 ENOG4108UQ5 membrane protein YcdZ HV304_RS15505 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV304_RS15510 ENOG4107SSZ Phosphatase HV304_RS15515 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HV304_RS15530 ENOG4105FR1 rard protein HV304_RS15535 ENOG4108MJ5 VirK protein HV304_RS15540 ENOG4105D5M phosphate starvation-inducible protein HV304_RS15550 ENOG4105DBE peroxidase HV304_RS15555 ENOG410650H (LipO)protein HV304_RS15565 ENOG4105CK7 Sodium proline symporter HV304_RS15570 ENOG4105C26 Dehydrogenase HV304_RS15575 ENOG4105VTN Protein of unknown function (DUF1311) HV304_RS15580 ENOG4108R86 Transcriptional regulator HV304_RS15590 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV304_RS15595 ENOG4105CS1 NAD(P)H quinone oxidoreductase HV304_RS15600 ENOG4105XH3 HV304_RS15605 ENOG4105D6F Phosphatase HV304_RS15610 ENOG4108ZHR arsR family transcriptional regulator HV304_RS15630 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HV304_RS15640 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HV304_RS15655 ENOG4107SJW iron permease, FTR1 HV304_RS15660 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV304_RS15665 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV304_RS15670 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV304_RS15685 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HV304_RS15690 ENOG4108Z33 Thiol disulfide Interchange Protein HV304_RS15695 ENOG4105DVC DnaJ domain protein HV304_RS15720 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type HV304_RS15735 ENOG4105EHG Permease protein HV304_RS15740 ENOG4105E0A ABC, transporter HV304_RS15750 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HV304_RS15755 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HV304_RS15770 ENOG4107QSI ABC, transporter HV304_RS15775 ENOG4108MN8 Membrane HV304_RS15785 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV304_RS15790 ENOG4105DR4 Methyltransferase HV304_RS15800 ENOG4105K4P CoA-binding domain protein HV304_RS15805 ENOG4108Q67 UPF0319 protein HV304_RS15810 ENOG4108Z5K methylglyoxal synthase HV304_RS15815 ENOG41088T4 Helicase IV HV304_RS15820 ENOG410901E Membrane HV304_RS15825 ENOG4105EM2 membrane HV304_RS15830 ENOG4108RZ1 DNA transformation protein HV304_RS15835 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HV304_RS15840 ENOG4105UYK outer membrane protein a HV304_RS15845 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HV304_RS15850 ENOG4105DAN ATP-dependent protease HV304_RS15860 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV304_RS15865 ENOG4108Q2G (LipO)protein HV304_RS15870 ENOG4105DY2 Paraquat-inducible protein b HV304_RS15875 ENOG4105F1S paraquat-inducible protein a HV304_RS15880 ENOG4105C5H ABC transporter HV304_RS15885 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HV304_RS15890 ENOG4105QVC MOSC domain-containing protein HV304_RS15895 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV304_RS15905 ENOG4108UZX fmn reductase HV304_RS15910 ENOG4105GVF (ABC) transporter HV304_RS15915 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HV304_RS15920 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV304_RS15925 ENOG4105E2Y ABC, transporter HV304_RS15930 ENOG4105CD8 aminopeptidase N HV304_RS15935 ENOG4107RH7 Nicotinate phosphoribosyltransferase HV304_RS15950 ENOG4105CGF Aromatic amino acid aminotransferase HV304_RS15955 ENOG4105C5X domain protein HV304_RS15960 ENOG4105EAQ (twin-arginine translocation) pathway signal HV304_RS15965 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV304_RS15970 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HV304_RS15975 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV304_RS15985 ENOG4106371 Methyltransferase HV304_RS15990 ENOG4107S90 membrAne HV304_RS15995 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV304_RS16000 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HV304_RS16010 ENOG4105T0Z Conserved Protein HV304_RS16015 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HV304_RS16020 ENOG4105BZ1 (ABC) transporter HV304_RS16025 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV304_RS16030 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV304_RS16035 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV304_RS16040 ENOG4105CAT Cytidine monophosphate kinase HV304_RS16045 ENOG4108K0D peptidase, M48 HV304_RS16050 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HV304_RS16055 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HV304_RS16060 ENOG4107VMU Membrane HV304_RS16065 ENOG4105DDY UPF0142 protein ycaO HV304_RS16070 ENOG4105TMB Formate nitrite transporter HV304_RS16075 ENOG4105C6N Formate acetyltransferase HV304_RS16080 ENOG4105F1A Pyruvate formate-lyase HV304_RS16085 ENOG4105E5D amino acid HV304_RS16090 ENOG4108ISG Major Facilitator HV304_RS16095 ENOG4105CHJ isochorismatase hydrolase HV304_RS16100 ENOG4107KGK dmso reductase anchor subunit HV304_RS16105 ENOG4105QAX Iron-sulfur HV304_RS16110 ENOG4107QY8 reductase HV304_RS16115 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HV304_RS16120 ENOG4105D1H recombination factor protein RarA HV304_RS16130 ENOG4105CNU cell division protein FtsK HV304_RS16135 ENOG4105EW9 transcriptional regulator AsnC family HV304_RS16140 ENOG4105C3M thioredoxin reductase HV304_RS16145 ENOG4108JJ9 ABC, transporter HV304_RS16150 ENOG4108JJ8 (ABC) transporter HV304_RS16155 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HV304_RS16170 ENOG4105HEI LysR family (Transcriptional regulator HV304_RS16175 ENOG4105EUB pirin domain protein HV304_RS16180 ENOG4105CHJ isochorismatase hydrolase HV304_RS16200 ENOG4105RBQ inner membrane protein ybjO HV304_RS16205 ENOG4105D38 putrescine abc transporter HV304_RS16210 ENOG4105F38 ABC transporter, permease HV304_RS16215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV304_RS16220 ENOG4107RUE extracellular solute-binding protein family 1 HV304_RS16225 ENOG4108RMJ sensory transduction regulator HV304_RS16230 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HV304_RS16235 ENOG4108DBC nitroreductase HV304_RS16240 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HV304_RS16245 ENOG41090BQ Glutaredoxin HV304_RS16250 ENOG4105GWF inner membrane protein YbjM HV304_RS16255 ENOG4105D0C transport protein HV304_RS16280 ENOG4105C5Q Transcriptional regulator HV304_RS16285 ENOG4108RFG Tetr family transcriptional regulator HV304_RS16290 ENOG4106UW1 Major Facilitator superfamily HV304_RS16295 ENOG4108HCJ Hydrolase HV304_RS16305 ENOG4107QF7 multi-drug HV304_RS16310 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV304_RS16315 ENOG4107FB0 transcriptional regulator DeoR family HV304_RS16320 ENOG4105DZ1 carboxypeptidase HV304_RS16325 ENOG4108TGY Glutathione S-transferase HV304_RS16330 ENOG4105D8V Glucose sorbosone dehydrogenase HV304_RS16335 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV304_RS16350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV304_RS16355 ENOG4105DEF Extracellular solute-binding protein, family 5 HV304_RS16360 ENOG4108JQ6 ABC transporter HV304_RS16365 ENOG4105D44 asparaginase HV304_RS16375 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV304_RS16380 ENOG4105D06 uba thif-type nad fad binding protein HV304_RS16385 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV304_RS16390 ENOG4105F1A Pyruvate formate-lyase HV304_RS16400 ENOG4108HCJ Hydrolase HV304_RS16405 ENOG41072TH Protein of unknown function (DUF1479) HV304_RS16410 ENOG4105C5H ABC transporter HV304_RS16415 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV304_RS16420 ENOG4105F4P )-transporter HV304_RS16425 ENOG4105KST dependent repressor HV304_RS16435 ENOG4108I6E Sulfatase HV304_RS16440 ENOG4108T1M outer membrane protein x HV304_RS16450 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HV304_RS16455 ENOG4107R0W ABC transporter HV304_RS16460 ENOG4105E5Q amino acid AbC transporter HV304_RS16465 ENOG4105CDA abc transporter atp-binding protein HV304_RS16470 ENOG4105D8X mechanosensitive ion channel HV304_RS16475 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HV304_RS16480 ENOG4105ZY9 UPF0379 protein ybiM HV304_RS16485 ENOG4108IU3 tonb-dependent siderophore receptor HV304_RS16495 ENOG4105KSC Transcriptional regulator, TraR DksA family HV304_RS16500 ENOG4105VR4 UPF0379 protein ybiJ HV304_RS16505 ENOG4105DG4 malate L-lactate dehydrogenase HV304_RS16510 ENOG4108MTB glycosyl transferase family HV304_RS16515 ENOG4105DVT helicase HV304_RS16520 ENOG4107QPK )-transporter HV304_RS16525 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HV304_RS16535 ENOG4105C1J atp-dependent rna helicase HV304_RS16540 ENOG4107MVR Transcriptional regulator HV304_RS16545 ENOG4105D0S secretion protein (HlyD HV304_RS16550 ENOG4105CJ1 ABC, transporter HV304_RS16555 ENOG4107QWP ABC-2 type transporter HV304_RS16560 ENOG4107QWP ABC-2 type transporter HV304_RS16565 ENOG4105I9U inner membrane protein ybhQ HV304_RS16570 ENOG4105X23 Endonuclease Exonuclease phosphatase HV304_RS16575 ENOG4105DZQ phospholipase D Transphosphatidylase HV304_RS16580 ENOG4107UXM Membrane HV304_RS16585 ENOG4105HFZ Membrane HV304_RS16590 ENOG4108ZAF Molybdopterin HV304_RS16595 ENOG4105M00 molybdopterin converting factor, subunit 1 HV304_RS16600 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HV304_RS16605 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV304_RS16615 ENOG4105CHW UPF0052 protein HV304_RS16620 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HV304_RS16630 ENOG4108IV0 ABC, transporter HV304_RS16635 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV304_RS16640 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV304_RS16645 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV304_RS16655 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV304_RS16660 ENOG4108V1U phospholipid-binding protein HV304_RS16665 ENOG4105C84 Histidine ammonia-lyase HV304_RS16670 ENOG4105CGP Urocanate hydratase HV304_RS16680 ENOG41088SP formiminoglutamate hydrolase HV304_RS16690 ENOG4105NBR Pectinesterase HV304_RS16700 ENOG4105F2I Transposase HV304_RS16710 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HV304_RS16715 ENOG4108K4B hydrolase HV304_RS16725 ENOG4105E0C molybdate abc transporter HV304_RS16730 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV304_RS16740 ENOG4105F4R Transcriptional regulator mode HV304_RS16745 ENOG4105DKW ABC transporter HV304_RS16750 ENOG4105CMR udp-glucose 4-epimerase HV304_RS16755 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV304_RS16760 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HV304_RS16765 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV304_RS16770 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV304_RS16775 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV304_RS16780 ENOG4105JND homeobox protein HV304_RS16785 ENOG4105PGM cation diffusion facilitator family transporter HV304_RS16790 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV304_RS16830 ENOG4105UFD tol-pal system protein YbgF HV304_RS16835 ENOG4105KCK Peptidoglycan-associated lipoprotein HV304_RS16845 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV304_RS16855 ENOG4105E02 MotA TolQ exbB proton channel HV304_RS16860 ENOG4107YD3 Thioesterase HV304_RS16865 ENOG4105KJB cyd operon protein YbgE HV304_RS16875 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV304_RS16880 ENOG4105C4M (Ubiquinol oxidase) subunit I HV304_RS16885 ENOG4107WFU Glutamate mutase subunit sigma HV304_RS16895 ENOG4105DJI Methylaspartate mutase, E subunit HV304_RS16920 ENOG4105CSV Glutaminase HV304_RS16925 ENOG4107GFK fumarate HV304_RS16930 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV304_RS16935 ENOG4105ETT transcriptional Regulator, LysR family HV304_RS16940 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV304_RS16945 ENOG4107XVH Transcriptional regulator HV304_RS16950 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV304_RS16955 ENOG4105CMV Succinyl-CoA synthetase subunit beta HV304_RS16960 ENOG4105C7S Dehydrogenase HV304_RS16965 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV304_RS16970 ENOG4105E33 succinate dehydrogenase HV304_RS16975 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV304_RS16980 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV304_RS16985 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV304_RS16990 ENOG4105BZN citrate synthase HV304_RS16995 ENOG4105GMB type VI secretion system effector, hcp1 family HV304_RS17010 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) HV304_RS17015 ENOG4108KK1 membrane protein AbrB duplication HV304_RS17025 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HV304_RS17040 ENOG4105E7W lamb ycsf family protein HV304_RS17045 ENOG4107R7A Allophanate hydrolase subunit 2 HV304_RS17050 ENOG4105P4J Allophanate hydrolase, subunit 1 HV304_RS17055 ENOG4107QNR UPF0135 protein HV304_RS17065 ENOG4105DNE Transposase HV304_RS17070 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV304_RS17075 ENOG4107SEY Conserved Protein HV304_RS17080 ENOG4105XIQ Protein of unknown function (DUF2517) HV304_RS17105 ENOG4105C08 Histidine kinase HV304_RS17110 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV304_RS17115 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV304_RS17120 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV304_RS17125 ENOG4105EV9 Alpha Beta Hydrolase HV304_RS17130 ENOG4105NNH LexA regulated protein HV304_RS17135 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV304_RS17145 ENOG41090R7 Ferric uptake HV304_RS17150 ENOG4106P55 Transcriptional regulator HV304_RS17155 ENOG4107EFR Flavocytochrome c HV304_RS17170 ENOG4105GX6 (LipO)protein HV304_RS17175 ENOG4105J5J Outer membrane porin HV304_RS17185 ENOG4105CI1 PTS System HV304_RS17195 ENOG4105CE4 GlcNAc 6-P deacetylase HV304_RS17200 ENOG4105E2R ROK family HV304_RS17205 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV304_RS17210 ENOG4105CAQ asparagine synthetase HV304_RS17255 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV304_RS17265 ENOG4105C9A Phoh family HV304_RS17275 ENOG4108JU5 Magnesium and cobalt efflux protein HV304_RS17280 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV304_RS17285 ENOG4107RP9 extracellular solute-binding protein, family 3 HV304_RS17290 ENOG4105EAD ABC transporter HV304_RS17295 ENOG4105DRP amino acid AbC transporter HV304_RS17300 ENOG4105CDA abc transporter atp-binding protein HV304_RS17310 ENOG4107PAI alpha helical protein HV304_RS17315 ENOG4105C8T Leucyl-tRNA synthetase HV304_RS17320 ENOG4108U2H Rare lipoprotein B HV304_RS17325 ENOG4105DJF DNA polymerase III, delta' subunit HV304_RS17330 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HV304_RS17335 ENOG4107QZB decarboxylase HV304_RS17340 ENOG4108TGR phosphatase HV304_RS17345 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV304_RS17350 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HV304_RS17355 ENOG4105CJN penicillin-binding protein HV304_RS17360 ENOG4105CNI cell division protein FtsW HV304_RS17365 ENOG4105K6T rare lipoprotein A HV304_RS17370 ENOG4105DZ1 carboxypeptidase HV304_RS17375 ENOG4108Z43 UPF0250 protein HV304_RS17380 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HV304_RS17410 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV304_RS17415 ENOG4105CEE C4-dicarboxylate transporter HV304_RS17420 ENOG4106YYS transcriptional regulatory protein HV304_RS17425 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV304_RS17430 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV304_RS17440 ENOG4105CI0 Citrate lyase HV304_RS17445 ENOG4105CHY citrate lyase, alpha HV304_RS17450 ENOG4105YGP holo-ACP synthase CitX HV304_RS17455 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HV304_RS17460 ENOG4107QPK )-transporter HV304_RS17465 ENOG4105KTS ribonuclease HV304_RS17480 ENOG4105NXH GreA GreB family elongation factor HV304_RS17485 ENOG4108U51 Universal stress protein HV304_RS17495 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV304_RS17500 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV304_RS17510 ENOG4108JU3 Alkyl hydroperoxide reductase HV304_RS17515 ENOG4105D3R alkyl hydroperoxide reductase HV304_RS17520 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV304_RS17525 ENOG4105DQS Transcriptional regulator HV304_RS17530 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV304_RS17535 ENOG4105GTN ParB Domain Protein Nuclease HV304_RS17540 ENOG4105CHM Aminotransferase HV304_RS17545 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV304_RS17550 ENOG4105VCD cytoplasmic protein HV304_RS17555 ENOG4105D22 carbon starvation protein HV304_RS17565 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV304_RS17570 ENOG4105WQI isochorismatase HV304_RS17575 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV304_RS17580 ENOG4105E4F Isochorismate synthase HV304_RS17585 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV304_RS17590 ENOG4105E8G Major facilitator Superfamily HV304_RS17595 ENOG4105DQ5 transport system permease protein HV304_RS17600 ENOG4105TVJ transport system, permease HV304_RS17605 ENOG4105E0A ABC, transporter HV304_RS17610 ENOG4108QY5 Ferric enterobactin transport protein HV304_RS17615 ENOG4105C0W non-ribosomal peptide synthetase HV304_RS17620 ENOG41085A6 mbth domain-containing protein HV304_RS17625 ENOG4105E93 esterase HV304_RS17630 ENOG4107RNH Outer membrane receptor FepA HV304_RS17635 ENOG4108TSE Transferase HV304_RS17645 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HV304_RS17650 ENOG4105WQ6 Membrane HV304_RS17655 ENOG4105HFT AraC family transcriptional regulator HV304_RS17665 ENOG41067SE Tetr family transcriptional regulator HV304_RS17670 ENOG4105MSB protein, conserved in bacteria HV304_RS17675 ENOG4108RCM Nitroreductase HV304_RS17680 ENOG4105CUY Mechanosensitive ion channel HV304_RS17685 ENOG4105C85 amino acid HV304_RS17695 ENOG4105F2I Transposase HV304_RS17705 ENOG4108EM1 reductase HV304_RS17710 ENOG4105CUW cytochrome C-TYPE protein HV304_RS17715 ENOG4106WF9 DNA-binding transcriptional regulator TorR HV304_RS17720 ENOG4108SV3 Tmao reductase system periplasmic protein tort HV304_RS17725 ENOG4105BZU Histidine kinase HV304_RS17735 ENOG4105F2I Transposase HV304_RS17740 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HV304_RS17745 ENOG4105WQ3 Rna-binding protein HV304_RS17765 ENOG4105S2T inner membrane protein YbcI HV304_RS17775 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV304_RS17785 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV304_RS17790 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV304_RS17800 ENOG4108UMI ABC transporter, permease HV304_RS17810 ENOG4105D01 (LipO)protein HV304_RS17815 ENOG4105FCK Membrane HV304_RS17820 ENOG4105CV6 ABC transporter, permease HV304_RS17825 ENOG4108I0Y (ABC) transporter HV304_RS17830 ENOG4108UJV acyl-CoA thioesterase i HV304_RS17835 ENOG4105E1F short-chain dehydrogenase reductase HV304_RS17840 ENOG4107QR8 Thioredoxin HV304_RS17845 ENOG4105C4B ABC transporter, permease HV304_RS17850 ENOG41083J0 (ABC) transporter HV304_RS17855 ENOG4107QX8 SPFH domain, Band 7 family protein HV304_RS17860 ENOG4105G5H Membrane HV304_RS17875 ENOG4108Z6Z Transcriptional regulator HV304_RS17895 ENOG41090JE Utilization Protein HV304_RS17905 ENOG4105EHG Permease protein HV304_RS17910 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV304_RS17915 ENOG4105C59 p-type ATPase HV304_RS17920 ENOG4105MBR gumn family HV304_RS17925 ENOG4108Z66 YbaK ebsC protein HV304_RS17930 ENOG4105CGH 5'-nucleotidase HV304_RS17935 ENOG4105EU0 Major facilitator Superfamily HV304_RS17940 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV304_RS17945 ENOG4107RE1 Inosine-guanosine kinase HV304_RS17960 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HV304_RS17965 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HV304_RS17970 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HV304_RS17975 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HV304_RS17980 ENOG4107QMP dna polymerase iii subunits gamma and tau HV304_RS17985 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HV304_RS17990 ENOG4105WD1 Membrane HV304_RS17995 ENOG4108URS primosomal replication protein n'' HV304_RS18000 ENOG4106428 Protein of unknown function (DUF2496) HV304_RS18005 ENOG4105EGS Mechanosensitive ion channel HV304_RS18010 ENOG4107XI7 Tetr family transcriptional regulator HV304_RS18015 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV304_RS18020 ENOG4105BZS acriflavin resistance protein HV304_RS18025 ENOG4108UKR Biofilm formation regulator YbaJ HV304_RS18035 ENOG4108UW5 maltose o-acetyltransferase HV304_RS18040 ENOG4105GSJ Inner membrane protein ylaC HV304_RS18050 ENOG4105NRA 50s ribosomal protein l31 type b HV304_RS18055 ENOG41066DG (EAL) domain protein HV304_RS18060 ENOG4105KCV RNA signal recognition particle 4.5S RNA HV304_RS18065 ENOG4108VW9 Membrane HV304_RS18070 ENOG4107U9B transcriptional regulator HV304_RS18090 ENOG41080UX Methyltransferase HV304_RS18095 ENOG4108MNP Glycoprotein polysaccharide metabolism HV304_RS18100 ENOG4105C29 acyl-CoA thioesterase HV304_RS18105 ENOG4105BZU Histidine kinase HV304_RS18110 ENOG4108YZA Nitrogen regulatory protein pii HV304_RS18115 ENOG4105BZ1 (ABC) transporter HV304_RS18120 ENOG4105BZ1 (ABC) transporter HV304_RS18125 ENOG4108XM1 transcriptional regulator AsnC family HV304_RS18135 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HV304_RS18140 ENOG4108NFA extracellular solute-binding protein HV304_RS18145 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HV304_RS18150 ENOG4108TGP Thioesterase superfamily protein HV304_RS18155 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV304_RS18160 ENOG4105EIN peptidylprolyl cis-trans isomerase HV304_RS18165 ENOG4105K70 DNA-binding protein HV304_RS18170 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV304_RS18175 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HV304_RS18190 ENOG4105M85 Bola protein HV304_RS18195 ENOG4105IEY (LipO)protein HV304_RS18200 ENOG4105EYM Major Facilitator superfamily HV304_RS18205 ENOG4105E2S oxidase) subunit II HV304_RS18210 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV304_RS18215 ENOG4105CCU oxidase (Subunit III) HV304_RS18220 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV304_RS18230 ENOG4107RDB Major Facilitator HV304_RS18235 ENOG4108VPT UPF0234 protein HV304_RS18240 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV304_RS18245 ENOG4107S0N DJ-1 family HV304_RS18265 ENOG4105CTB Polyprenyl synthetase HV304_RS18275 ENOG4105CPC Aldo Keto reductase HV304_RS18280 ENOG4108ZAI phosphatidylglycerophosphatase a HV304_RS18285 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV304_RS18290 ENOG4107YIM Involved in the transcription termination process (By similarity) HV304_RS18295 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV304_RS18300 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV304_RS18310 ENOG4108KIC (LipO)protein HV304_RS18315 ENOG4105DRB nucleoside-specific channel-forming protein HV304_RS18330 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV304_RS18335 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV304_RS18340 ENOG4105VIE preprotein translocase, subunit YajC HV304_RS18345 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HV304_RS18350 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HV304_RS18360 ENOG4105D3R alkyl hydroperoxide reductase HV304_RS18365 ENOG4105EFZ amidohydrolase HV304_RS18375 ENOG4105CHJ isochorismatase hydrolase HV304_RS18380 ENOG4105EQ1 Transcriptional regulator HV304_RS18385 ENOG4107R28 alpha amylase, catalytic region HV304_RS18390 ENOG4105C85 amino acid HV304_RS18395 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV304_RS18400 ENOG4105BZU Histidine kinase HV304_RS18410 ENOG4107RH8 nuclease SbcCD subunit D HV304_RS18415 ENOG4105EYH Exonuclease HV304_RS18420 ENOG4105F27 Major Facilitator HV304_RS18425 ENOG4105DKQ ROK family HV304_RS18435 ENOG4105NBK UPF0345 protein HV304_RS18440 ENOG4105HBA AroM protein HV304_RS18445 ENOG4105SS3 HV304_RS18455 ENOG4108UPT UPF0178 protein HV304_RS18460 ENOG4105II7 pyrroline-5-carboxylate reductase HV304_RS18465 ENOG4105BZU Histidine kinase HV304_RS18470 ENOG4105VIF phosphate starvation-inducible protein HV304_RS18475 ENOG4105G6Z alkaline phosphatase HV304_RS18490 ENOG4105CPF Cell wall formation (By similarity) HV304_RS18495 ENOG4105UNH Membrane HV304_RS18500 ENOG4105FR5 inner membrane protein YaiY HV304_RS18505 ENOG4107QS8 (LipO)protein HV304_RS18510 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV304_RS18515 ENOG4107R6D beta-lactam binding protein AmpH HV304_RS18520 ENOG4108PNB DNA-binding transcriptional regulator HV304_RS18525 ENOG4108NSE outer membrane autotransporter barrel HV304_RS18530 ENOG4105D52 delta-aminolevulinic acid dehydratase HV304_RS18535 ENOG4105E2B Taurine dioxygenase HV304_RS18540 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV304_RS18545 ENOG4108ETV ABC transporter HV304_RS18550 ENOG4106FTQ Taurine ABC transporter, periplasmic HV304_RS18555 ENOG4108KX4 response regulator HV304_RS18560 ENOG4105BZU Histidine kinase HV304_RS18565 ENOG4105CXY transporter HV304_RS18570 ENOG4105C4Y ABC transporter HV304_RS18575 ENOG4107RCV ABC transporter, permease HV304_RS18580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV304_RS18585 ENOG4107QK5 Homocysteine s-methyltransferase HV304_RS18590 ENOG4108IQI permease HV304_RS18595 ENOG4108SC4 )-transporter HV304_RS18630 ENOG4108K2P TRANSCRIPTIONal HV304_RS18655 ENOG4105N0E Protein of unknown function (DUF2543) HV304_RS18660 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HV304_RS18675 ENOG4105ETE Transcriptional regulator (LacI family HV304_RS18680 ENOG4105CNT hydrolase family 2 HV304_RS18695 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV304_RS18700 ENOG4105DXD 2-methylcitrate dehydratase HV304_RS18705 ENOG4105BZN citrate synthase HV304_RS18710 ENOG4105CR4 methylisocitrate lyase HV304_RS18715 ENOG4108JU7 Transcriptional regulator HV304_RS18720 ENOG4105TDT uncharacterized protein yahO HV304_RS18725 ENOG4105E82 cytochrome subunit of dehydrogenase HV304_RS18730 ENOG4105BZU Histidine kinase HV304_RS18735 ENOG4105HEE Binding Domain protein HV304_RS18740 ENOG4106KNT transcriptional regulator HV304_RS18750 ENOG4108U1V ABC transporter, permease HV304_RS18755 ENOG4105DQ5 transport system permease protein HV304_RS18760 ENOG4105E0A ABC, transporter HV304_RS18785 ENOG4105ETT transcriptional Regulator, LysR family HV304_RS18805 ENOG4105CEE C4-dicarboxylate transporter HV304_RS18810 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV304_RS18820 ENOG4105DTA methyltransferase HV304_RS18825 ENOG4107R7Y intracellular protease Pfpi family HV304_RS18830 ENOG4105F2I Transposase HV304_RS18835 ENOG4105BZU Histidine kinase HV304_RS18845 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV304_RS18850 ENOG4105F2I Transposase HV304_RS18875 ENOG4108M0B Sucrose porin HV304_RS18900 ENOG4105F9F transposase HV304_RS18920 ENOG4108MXD gtp-binding protein HV304_RS18925 ENOG4106H6R UPF0380 protein HV304_RS18930 ENOG4108KZE transcriptional regulator HV304_RS18960 ENOG4105C94 Transporter HV304_RS18970 ENOG4105MFG Antirestriction protein HV304_RS18975 ENOG4108XS9 dna repair protein HV304_RS18980 ENOG4105ZS6 Protein of unknown function (DUF987) HV304_RS18990 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV304_RS19015 ENOG4105F2I Transposase HV304_RS19025 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV304_RS19030 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HV304_RS19035 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HV304_RS19045 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HV304_RS19060 ENOG4105CIN aminoacyl-histidine dipeptidase HV304_RS19065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV304_RS19080 ENOG4107RD7 Flagellar Motor Protein, MotA HV304_RS19110 ENOG410804A Flagellar hook-associated 2 domain-containing protein HV304_RS19115 ENOG4105I03 Flagellin HV304_RS19135 ENOG4105DTJ flagellar hook-associated protein HV304_RS19140 ENOG4105E1Q flagellar hook-associated protein HV304_RS19145 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV304_RS19160 ENOG4105CGA flagellar basal-body rod protein FlgG HV304_RS19165 ENOG4108KPB Flagellar basal-body rod protein FlgF HV304_RS19180 ENOG4108ZC9 flagellar basal-body rod protein flgc HV304_RS19215 ENOG4105F2I Transposase HV304_RS19250 ENOG4108JIR Flagellum-specific ATP synthase HV304_RS19260 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV304_RS19285 ENOG4105DD5 Flagellar motor switch protein HV304_RS19290 ENOG4105CN7 Flagellar biosynthetic protein FliP HV304_RS19295 ENOG4105VS8 Flagellar biosynthetic protein fliq HV304_RS19300 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV304_RS19305 ENOG4105D00 flagellar biosynthetic protein flhB HV304_RS19315 ENOG4108YS0 lipoprotein YafL HV304_RS19320 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV304_RS19325 ENOG4105E7A Glutamine amidotransferase HV304_RS19335 ENOG4107QPN acyl-Coa dehydrogenase HV304_RS19340 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV304_RS19350 ENOG4105CMB EAL domain-containing protein HV304_RS19365 ENOG4108MDY Fimbrial HV304_RS19375 ENOG4108FZ9 Chaperone HV304_RS19380 ENOG4106PG1 outer membrane usher protein HV304_RS19390 ENOG4108TH4 Major fimbrial subunit HV304_RS19395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV304_RS19410 ENOG4107RZZ dna polymerase iii epsilon subunit HV304_RS19415 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV304_RS19420 ENOG4105D1A Methyltransferase HV304_RS19430 ENOG4105E9H Lytic Murein transglycosylase HV304_RS19435 ENOG4105F2W methyltransferase HV304_RS19445 ENOG4105F27 Major Facilitator HV304_RS19450 ENOG4105HEI LysR family (Transcriptional regulator HV304_RS19455 ENOG4105CV8 reductase HV304_RS19485 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV304_RS19490 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV304_RS19495 ENOG4108UMI ABC transporter, permease HV304_RS19500 ENOG4105D01 (LipO)protein HV304_RS19505 ENOG4108R8X outer membrane lipoprotein HV304_RS19510 ENOG4108R96 Methyltransferase, YaeB family HV304_RS19515 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HV304_RS19520 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV304_RS19525 ENOG4108YZN class I peptide chain release factor HV304_RS19530 ENOG4108VWS Yaeq family HV304_RS19540 ENOG4105M1T rho-binding antiterminator HV304_RS19545 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV304_RS19550 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV304_RS19555 ENOG4105CXN decarboxylase HV304_RS19560 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HV304_RS19565 ENOG4105C0B DNA polymerase III (alpha subunit) HV304_RS19570 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV304_RS19575 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV304_RS19590 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV304_RS19595 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV304_RS19610 ENOG4105KNE Phosphatidate cytidylyltransferase HV304_RS19620 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV304_RS19630 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HV304_RS19640 ENOG4105CE9 30S ribosomal protein S2 HV304_RS19645 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV304_RS19650 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HV304_RS19655 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HV304_RS19665 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV304_RS19670 ENOG4105C0H protease HV304_RS19675 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HV304_RS19680 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HV304_RS19685 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV304_RS19690 ENOG4105EN6 Membrane HV304_RS19695 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HV304_RS19700 ENOG4105CMQ Chloride channel HV304_RS19710 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV304_RS19715 ENOG4105J76 Periplasmic binding protein HV304_RS19720 ENOG4105E0A ABC, transporter HV304_RS19725 ENOG4105E0K tonB-dependent siderophore receptor HV304_RS19730 ENOG4108WDE Fimbrial protein HV304_RS19735 ENOG4105CW0 outer membrane usher protein HV304_RS19740 ENOG4108NAE Fimbrial chaperone protein HV304_RS19750 ENOG4105BZ4 penicillin-binding protein HV304_RS19755 ENOG4105CQ7 ATP-dependent helicase HV304_RS19760 ENOG4107XID 2'-5' rna ligase HV304_RS19765 ENOG4105PW4 Sugar fermentation stimulation protein homolog HV304_RS19770 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HV304_RS19775 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HV304_RS19780 ENOG4105DJ0 Poly(A) Polymerase HV304_RS19785 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV304_RS19805 ENOG4107BJW polysaccharide deacetylase HV304_RS19810 ENOG4108YTN IIa component HV304_RS19815 ENOG4105E3A (ABC) transporter HV304_RS19820 ENOG4105DA5 (ABC) transporter HV304_RS19825 ENOG41077A9 carbonic anhydrase HV304_RS19830 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV304_RS19835 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS19840 ENOG4105E3B Multicopper oxidase HV304_RS19845 ENOG4108ZRK uncharacterized protein yacC HV304_RS19850 ENOG4108ZIG UPF0231 protein HV304_RS19855 ENOG4107QIJ Aconitate hydratase 2 HV304_RS19860 ENOG4108NST exported protein HV304_RS19875 ENOG4107QN2 dihydrolipoyl dehydrogenase HV304_RS19880 ENOG4107QSN dihydrolipoamide acetyltransferase HV304_RS19885 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV304_RS19895 ENOG4105C85 amino acid HV304_RS19900 ENOG4105CT4 transporter HV304_RS19905 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HV304_RS19910 ENOG4106A72 regulatory protein AmpE HV304_RS19920 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV304_RS19925 ENOG4108ZUW Major pilin subunit HV304_RS19930 ENOG4107QHF type ii secretion system protein e HV304_RS19935 ENOG4105D7Q type ii secretion system HV304_RS19940 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV304_RS19945 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV304_RS19950 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HV304_RS19955 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HV304_RS19960 ENOG4105M6F mutator MutT protein HV304_RS19970 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HV304_RS19980 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV304_RS19985 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV304_RS19990 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV304_RS19995 ENOG4105CPF Cell wall formation (By similarity) HV304_RS20005 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HV304_RS20010 ENOG4105CNI cell division protein FtsW HV304_RS20015 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HV304_RS20020 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HV304_RS20025 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV304_RS20030 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV304_RS20035 ENOG4105CJN penicillin-binding protein HV304_RS20040 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV304_RS20050 ENOG4108V6E Cell division protein mraZ HV304_RS20055 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV304_RS20060 ENOG4108ZP8 Acetolactate synthase small subunit HV304_RS20065 ENOG4105C7K acetolactate synthase HV304_RS20070 ENOG41064T2 transcriptional regulator, lysR family HV304_RS20100 ENOG4105K2J Transcriptional regulator HV304_RS20105 ENOG4105C57 major facilitator superfamily HV304_RS20110 ENOG4105CHR reductase HV304_RS20115 ENOG4105S8Q sugar efflux transporter HV304_RS20135 ENOG4106SMU thiamine transporter membrane protein HV304_RS20140 ENOG4107T0D ABC, transporter HV304_RS20145 ENOG4108KF1 Membrane HV304_RS20165 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV304_RS20175 ENOG4105CQ2 DNA polymerase HV304_RS20180 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HV304_RS20185 ENOG4105D3G Pseudouridine synthase HV304_RS20195 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HV304_RS20205 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HV304_RS20210 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HV304_RS20215 ENOG4105NWN ApaG protein HV304_RS20220 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HV304_RS20240 ENOG4105M5B (LipO)protein HV304_RS20245 ENOG4105C54 Major Facilitator superfamily HV304_RS20250 ENOG4105WQV ferredoxin-like protein HV304_RS20255 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV304_RS20270 ENOG4105F2I Transposase HV304_RS20305 ENOG4108XNW Transcriptional activatory protein CaiF HV304_RS20310 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV304_RS20315 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV304_RS20320 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HV304_RS20325 ENOG4105DU0 nucleoside hydrolase HV304_RS20330 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HV304_RS20335 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV304_RS20345 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HV304_RS20350 ENOG4105DTN riboflavin biosynthesis protein ribF HV304_RS20370 ENOG41063Z6 transcriptional regulator, lysR family HV304_RS20385 ENOG4105CFG Acts as a chaperone (By similarity) HV304_RS20395 ENOG4108QUJ UPF0174 protein YaaW HV304_RS20400 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV304_RS20410 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV304_RS20415 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV304_RS20420 ENOG4105BZG amino acid carrier protein HV304_RS20425 ENOG4105D1Q UPF0246 protein HV304_RS20430 ENOG4105D98 threonine synthase HV304_RS20435 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HV304_RS20440 ENOG4105CFH Aspartokinase HV304_RS20450 ENOG4106FVC RNA methyltransferase HV304_RS20455 ENOG410759A HV304_RS20460 ENOG41065U4 response regulator HV304_RS20465 ENOG4105CT7 inner membrane cred family protein HV304_RS20470 ENOG4105EB3 Histidine kinase HV304_RS20475 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV304_RS20480 ENOG4108RH0 Crea protein HV304_RS20485 ENOG4105UEI Transcriptional Regulator AraC Family HV304_RS20490 ENOG4105CVJ phosphoglycerate mutase HV304_RS20495 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV304_RS20505 ENOG4107SC1 transglycosylase HV304_RS20510 ENOG4105C5H ABC transporter HV304_RS20515 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV304_RS20520 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV304_RS20525 ENOG4105EAC phosphoserine phosphatase HV304_RS20530 ENOG41062Z9 Membrane HV304_RS20560 ENOG4105G0K glycine radical enzyme YjjI family HV304_RS20565 ENOG41076CZ activating enzyme HV304_RS20570 ENOG4105EYA deoxyribonuclease HV304_RS20575 ENOG4108NRW Phospholipase, patatin family HV304_RS20585 ENOG4105K3G Periplasmic Protein HV304_RS20590 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HV304_RS20595 ENOG4105PAD Hydrolase HV304_RS20600 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV304_RS20605 ENOG4108WPU DNA polymerase III subunit psi HV304_RS20610 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV304_RS20630 ENOG4105YBH Protein of unknown function (DUF1435) HV304_RS20635 ENOG4105BZU Histidine kinase HV304_RS20640 ENOG4108819 ferric iron reductase HV304_RS20645 ENOG4105CK1 PTS System HV304_RS20650 ENOG4108UIN ybak prolyl-trna synthetase associated region HV304_RS20655 ENOG4108T94 DNA-binding transcriptional activator BglJ HV304_RS20665 ENOG4105DWK Membrane HV304_RS20670 ENOG4107XM3 UPF0442 protein HV304_RS20680 ENOG4106CVF DNA replication protein HV304_RS20685 ENOG4105RI1 glycoprotein receptor HV304_RS20695 ENOG4107QZW Altronate oxidoreductase HV304_RS20700 ENOG4105CPQ Dehydrogenase HV304_RS20705 ENOG410617M Transcriptional regulator HV304_RS20710 ENOG4108I5G Major Facilitator superfamily HV304_RS20715 ENOG4105XYF acetyltransferase HV304_RS20720 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS20730 ENOG4105D22 carbon starvation protein HV304_RS20735 ENOG4105VCD cytoplasmic protein HV304_RS20740 ENOG4105CKI cobalamin synthesis protein HV304_RS20750 ENOG4105EFX secretion protein, HlyD family HV304_RS20760 ENOG4106DIZ Domain of unknown function (DUF1127) HV304_RS20765 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV304_RS20770 ENOG4105DNE Transposase HV304_RS20785 ENOG41083G8 Multidrug resistance protein MdtM HV304_RS20790 ENOG4105C28 cystathionine HV304_RS20795 ENOG4105CK2 sodium dicarboxylate symporter HV304_RS20800 ENOG410642W LysR family Transcriptional regulator HV304_RS20805 ENOG4106BRA Membrane HV304_RS20815 ENOG4105CBP Major Facilitator HV304_RS20835 ENOG4105C6F GntR Family Transcriptional Regulator HV304_RS20840 ENOG4105DEI Mannitol dehydrogenase HV304_RS20850 ENOG4107EFN gluconate transport system permease 3 HV304_RS20855 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HV304_RS20860 ENOG4107QR9 Iron-sulfur cluster binding protein HV304_RS20865 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV304_RS20915 ENOG4105F2I Transposase HV304_RS20920 ENOG4105C4R Atp-dependent dna helicase HV304_RS20940 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV304_RS21005 ENOG4105DQ4 alcohol dehydrogenase HV304_RS21010 ENOG4105D7A ATP-binding protein HV304_RS21015 ENOG4108K5H permease YjgP YjgQ family protein HV304_RS21020 ENOG4108M8S permease YjgP YjgQ family protein HV304_RS21025 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV304_RS21030 ENOG4105MYG DNA polymerase iii, chi subunit HV304_RS21035 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV304_RS21040 ENOG4108M3P Membrane HV304_RS21045 ENOG4108MJ3 acetyltransferase HV304_RS21055 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HV304_RS21060 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV304_RS21070 ENOG4105XEP YhcH YjgK YiaL family protein HV304_RS21090 ENOG4105DBV ornithine carbamoyltransferase HV304_RS21095 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV304_RS21100 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV304_RS21110 ENOG4107C93 pyrBI operon leader peptide HV304_RS21125 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HV304_RS21130 ENOG4105KME endoribonuclease L-psp HV304_RS21135 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV304_RS21145 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV304_RS21155 ENOG4105D4X repressor HV304_RS21160 ENOG4105C5Y PTS System HV304_RS21165 ENOG4105CG3 alpha amylase, catalytic region HV304_RS21170 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV304_RS21175 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV304_RS21180 ENOG4105K4U addiction module toxin, RelE StbE family HV304_RS21190 ENOG4105EMD TRANSCRIPTIONal HV304_RS21205 ENOG41069H0 dihydroorotase EC 3.5.2.3 HV304_RS21235 ENOG4108XVM Cytochrome b(562) HV304_RS21240 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV304_RS21245 ENOG4105N42 UPF0307 protein HV304_RS21250 ENOG4105DFU Cell wall formation (By similarity) HV304_RS21260 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS21265 ENOG41062B0 ABC transporter, permease HV304_RS21270 ENOG4107R9N ABC transporter HV304_RS21275 ENOG4105C2J ABC transporter HV304_RS21280 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV304_RS21285 ENOG4105F0N pyrophosphate phospho-hydrolase HV304_RS21290 ENOG4108ZHD aig2 family HV304_RS21295 ENOG4105MA0 exported protein HV304_RS21300 ENOG4105CFU surface antigen HV304_RS21310 ENOG4105C37 (CBS) domain HV304_RS21315 ENOG41061GZ Protein of unknown function (DUF1107) HV304_RS21320 ENOG4108UUE Transcriptional regulator HV304_RS21325 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV304_RS21330 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HV304_RS21335 ENOG4105KVH Transcriptional regulator HV304_RS21340 ENOG4105ECR NmrA family HV304_RS21350 ENOG4105DXC membrane HV304_RS21355 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS21360 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HV304_RS21365 ENOG4105C85 amino acid HV304_RS21370 ENOG4108V1T peptidylprolyl cis-trans isomerase HV304_RS21375 ENOG4105FHY Opacity-associated protein A HV304_RS21385 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HV304_RS21390 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV304_RS21395 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HV304_RS21405 ENOG4105EJ9 Membrane HV304_RS21410 ENOG4105KIT UPF0379 protein yjfY HV304_RS21425 ENOG4105H6Q decarboxylase HV304_RS21450 ENOG4105DW5 Transcriptional regulator HV304_RS21455 ENOG4108MXZ Esterase HV304_RS21460 ENOG4105WSB biofilm stress and motility protein A HV304_RS21465 ENOG4105S17 UPF0379 protein yjfN HV304_RS21470 ENOG4105CSU acyl-Coa dehydrogenase HV304_RS21475 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV304_RS21480 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV304_RS21490 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HV304_RS21500 ENOG4105EPW hflc protein HV304_RS21505 ENOG4107QJR hflk protein HV304_RS21510 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV304_RS21515 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HV304_RS21525 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HV304_RS21530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV304_RS21535 ENOG4105K8N protein family UPF0079, ATPase HV304_RS21540 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV304_RS21545 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV304_RS21575 ENOG4105DJ4 phosphatidylserine decarboxylase HV304_RS21580 ENOG4105EGS Mechanosensitive ion channel HV304_RS21585 ENOG4107SC7 Inner membrane transporter yjeM HV304_RS21590 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HV304_RS21595 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV304_RS21600 ENOG4105E33 succinate dehydrogenase HV304_RS21605 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HV304_RS21610 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HV304_RS21655 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV304_RS21660 ENOG4105MTB Uncharacterized protein YjeJ HV304_RS21665 ENOG4108ZVF (LipO)protein HV304_RS21670 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HV304_RS21680 ENOG4105DVH amino acid HV304_RS21685 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV304_RS21690 ENOG4108IJ0 Aspartate ammonia-lyase HV304_RS21695 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV304_RS21705 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV304_RS21710 ENOG4108SIC Transcriptional regulator HV304_RS21740 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV304_RS21775 ENOG4108QDQ Ubiquinol-cytochrome C chaperone HV304_RS21780 ENOG4108KZE transcriptional regulator HV304_RS21790 ENOG4105F2I Transposase HV304_RS21805 ENOG4105CI1 PTS System HV304_RS21815 ENOG4105F2I Transposase HV304_RS21830 ENOG4105F2I Transposase HV304_RS21835 ENOG4105CEY Amp-dependent synthetase and ligase HV304_RS21865 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV304_RS21870 ENOG4108MRH transcriptional regulatory protein HV304_RS21875 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV304_RS21880 ENOG4107GFK fumarate HV304_RS21885 ENOG4108R5S membrane HV304_RS21895 ENOG4105CT4 transporter HV304_RS21900 ENOG4105F8D glycoside hydrolase family 4 HV304_RS21905 ENOG4108K2B transcriptional regulator HV304_RS21910 ENOG4105CXN decarboxylase HV304_RS21915 ENOG4106ZGR Transcriptional regulator HV304_RS21920 ENOG4105D5Q Arginine ornithine antiporter HV304_RS21925 ENOG4105DIJ Phosphoethanolamine transferase HV304_RS21930 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV304_RS21935 ENOG4105ECM Sensor protein basS pmrB HV304_RS21945 ENOG4105CSH Transporter HV304_RS21950 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HV304_RS21955 ENOG4108YIV HV304_RS21960 ENOG4108F5E vimentin HV304_RS21965 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV304_RS21970 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV304_RS21975 ENOG4105D5T phosphonate abc transporter HV304_RS21980 ENOG4105EHI Phosphonate ABC transporter, periplasmic HV304_RS21990 ENOG4107RJJ Transcriptional regulator HV304_RS21995 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HV304_RS22000 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HV304_RS22005 ENOG4105EKV Phosphonate metabolism protein HV304_RS22010 ENOG4105FT8 Phosphonate metabolism HV304_RS22015 ENOG4105ENV phosphonate C-P lyase system protein PhnK HV304_RS22020 ENOG4105HRV phosphonate c-p lyase system protein phnl HV304_RS22025 ENOG4105FD8 phosphonate metabolism protein PhnM HV304_RS22030 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HV304_RS22035 ENOG410849A acetyltransferase, (GNAT) family HV304_RS22040 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HV304_RS22045 ENOG41081XE plasmid maintenance system antidote protein, xre family HV304_RS22050 ENOG41080ET plasmid maintenance system killer protein HV304_RS22065 ENOG4105C2J ABC transporter HV304_RS22070 ENOG4105CNN ABC, transporter HV304_RS22075 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV304_RS22085 ENOG4105D2N Aldolase HV304_RS22100 ENOG4105EUZ Beta-lactamase domain protein HV304_RS22105 ENOG4106833 HV304_RS22110 ENOG4105J12 Multidrug resistance protein mdtN HV304_RS22115 ENOG4108MI0 Resistance protein HV304_RS22120 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV304_RS22130 ENOG41082ND Uncharacterized protein yjcO HV304_RS22135 ENOG4105CK2 sodium dicarboxylate symporter HV304_RS22140 ENOG4108W0S formate-dependent nitrite reductase complex HV304_RS22150 ENOG4108QKW cytochrome c-type biogenesis protein HV304_RS22155 ENOG4105DVI reductase, NrfD HV304_RS22160 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV304_RS22165 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HV304_RS22175 ENOG4105CVR type I restriction-modification system HV304_RS22195 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV304_RS22200 ENOG41062QD Membrane HV304_RS22205 ENOG4107QN1 sodium solute HV304_RS22210 ENOG41067MG lrgb family HV304_RS22220 ENOG4105CMU LysR family (Transcriptional regulator HV304_RS22225 ENOG4105EEQ Na H antiporter HV304_RS22230 ENOG4105C7N Xanthine uracil vitamin C permease HV304_RS22235 ENOG4108Z4X TRANSCRIPTIONal HV304_RS22240 ENOG4108W3Q Transcriptional regulator HV304_RS22245 ENOG4108M8H domain protein HV304_RS22250 ENOG4105PMV Membrane HV304_RS22270 ENOG4108UUM single-stranded DNA-binding protein HV304_RS22275 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV304_RS22280 ENOG4105MSB protein, conserved in bacteria HV304_RS22285 ENOG4105F0S class B acid phosphatase HV304_RS22290 ENOG4105CGF Aromatic amino acid aminotransferase HV304_RS22300 ENOG4105CDU Replicative dna helicase HV304_RS22305 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV304_RS22310 ENOG4105P4Z Phage shock protein G HV304_RS22315 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV304_RS22325 ENOG4105MYN Zinc uptake regulation protein HV304_RS22330 ENOG4105VDW Csbd family HV304_RS22335 ENOG4107R73 Mate efflux family protein HV304_RS22345 ENOG41080IJ Diacylglycerol kinase HV304_RS22350 ENOG4105E55 glycerol-3-phosphate acyltransferase HV304_RS22355 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HV304_RS22360 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HV304_RS22365 ENOG4107W52 maltose operon periplasmic protein HV304_RS22375 ENOG4108IJ9 (ABC) transporter HV304_RS22380 ENOG4107FKK extracellular solute-binding protein family 1 HV304_RS22385 ENOG4105D56 permease protein HV304_RS22390 ENOG4105EG2 ABC transporter, permease HV304_RS22395 ENOG4105C87 Aminotransferase class I and II HV304_RS22400 ENOG4105DFD Na H antiporter HV304_RS22405 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HV304_RS22410 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV304_RS22415 ENOG4105E3R (LipO)protein HV304_RS22420 ENOG4108Q9C Periplasmic Protein HV304_RS22425 ENOG4108MDC (LipO)protein HV304_RS22440 ENOG4105CFH Aspartokinase HV304_RS22445 ENOG410756H nucleotidyltransferase HV304_RS22455 ENOG4105CYB regulatoR HV304_RS22470 ENOG4108ZR5 Conserved Protein HV304_RS22475 ENOG4105FE9 pseudouridine synthase HV304_RS22480 ENOG4105DKT Transcriptional regulator HV304_RS22485 ENOG4105CHR reductase HV304_RS22490 ENOG4108XCU pts system HV304_RS22495 ENOG4105KPI PTS system sorbose subfamily IIB component HV304_RS22500 ENOG4105ETZ PTS System HV304_RS22505 ENOG4105F3R pts system mannose fructose sorbose family iid HV304_RS22510 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV304_RS22515 ENOG4105F9E Shikimate 5-dehydrogenase HV304_RS22530 ENOG4105YES addiction module antidote protein HV304_RS22550 ENOG4105EAM Na Pi-cotransporter HV304_RS22555 ENOG4105C3R Methionine synthase HV304_RS22560 ENOG41069M3 Transcriptional regulator HV304_RS22565 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HV304_RS22570 ENOG4108I9X Isocitrate lyase HV304_RS22575 ENOG4107QP3 malate synthase g HV304_RS22580 ENOG4105CVG Homoserine O-transsuccinylase HV304_RS22585 ENOG4105K5X acetyltransferase HV304_RS22605 ENOG4105DC1 bifunctional purine biosynthesis protein purh HV304_RS22610 ENOG4105C12 Phosphoribosylglycinamide synthetase HV304_RS22615 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV304_RS22620 ENOG4105BZU Histidine kinase HV304_RS22630 ENOG4108T8B Protein of unknown function (DUF1481) HV304_RS22635 ENOG4105K70 DNA-binding protein HV304_RS22640 ENOG4105R2J Conserved Protein HV304_RS22650 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HV304_RS22660 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HV304_RS22675 ENOG4105D06 uba thif-type nad fad binding protein HV304_RS22680 ENOG4105WHD thiamine biosynthesis protein ThiS HV304_RS22690 ENOG4105D41 biosynthesis protein thiH HV304_RS22695 ENOG4105VEQ Cold shock protein HV304_RS22705 ENOG4105VCP PTS System HV304_RS22710 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV304_RS22715 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV304_RS22720 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HV304_RS22725 ENOG4108VZM 50s ribosomal protein L10 HV304_RS22730 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HV304_RS22735 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HV304_RS22740 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV304_RS22745 ENOG4105PM1 preprotein translocase subunit SecE HV304_RS22780 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV304_RS22785 ENOG4105D4A Cell wall formation (By similarity) HV304_RS22830 ENOG4108Y73 Membrane HV304_RS22835 ENOG4105EJ2 Transcriptional regulator HV304_RS22845 ENOG4105C5Q Transcriptional regulator HV304_RS22850 ENOG4105CH7 arginosuccinase HV304_RS22855 ENOG4105CAS nag kinase HV304_RS22865 ENOG4105CWC Acetylornithine deacetylase HV304_RS22870 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HV304_RS22875 ENOG4105DIJ Phosphoethanolamine transferase HV304_RS22880 ENOG4106R3P AraC family transcriptional regulator HV304_RS22890 ENOG4105DCT glycerol dehydrogenase HV304_RS22895 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HV304_RS22900 ENOG4105SYT Methylenetetrahydrofolate reductase HV304_RS22905 ENOG4105CN8 Transcriptional regulator HV304_RS22910 ENOG4108Z8I decarboxylase HV304_RS22915 ENOG4105CGH 5'-nucleotidase HV304_RS22925 ENOG4105CFH Aspartokinase HV304_RS22930 ENOG4105C28 cystathionine HV304_RS22935 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HV304_RS22940 ENOG4105CT4 transporter HV304_RS22945 ENOG4108QGT oligogalacturonate-specific porin HV304_RS22950 ENOG4105VFB Binds the 23S rRNA (By similarity) HV304_RS22955 ENOG4105C25 Primosomal protein n' HV304_RS22960 ENOG4105ETE Transcriptional regulator (LacI family HV304_RS22965 ENOG41063M6 Cell Division Protein HV304_RS22975 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HV304_RS22980 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV304_RS22990 ENOG4105CHR reductase HV304_RS22995 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HV304_RS23000 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV304_RS23005 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV304_RS23010 ENOG4105CBT Fructose-1,6-bisphosphatase HV304_RS23015 ENOG4105DP0 ferredoxin-NADP reductase HV304_RS23020 ENOG4108VTS Membrane HV304_RS23025 ENOG4105EBK exported protein HV304_RS23035 ENOG4107QPK )-transporter HV304_RS23045 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HV304_RS23050 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV304_RS23055 ENOG4105CTQ phosphohexokinase HV304_RS23060 ENOG41076HS cation diffusion facilitator family transporter HV304_RS23065 ENOG4105FMW periplasmic HV304_RS23070 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV304_RS23075 ENOG4105E0F Histidine kinase HV304_RS23080 ENOG4108RPX mosc domain containing protein HV304_RS23085 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV304_RS23095 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV304_RS23100 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HV304_RS23105 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV304_RS23110 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV304_RS23120 ENOG4105DKG l-rhamnose isomerase HV304_RS23130 ENOG4105C0A alcohol dehydrogenase HV304_RS23145 ENOG4108UMN azlc family HV304_RS23155 ENOG41064BA PTS system, fructose-specific, IIA component HV304_RS23160 ENOG4105DM4 PTS System HV304_RS23165 ENOG4105CN9 Peptidase m42 family protein HV304_RS23170 ENOG4106C3V frv operon regulatory protein HV304_RS23190 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HV304_RS23200 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV304_RS23205 ENOG4108MG3 formate dehydrogenase HV304_RS23210 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HV304_RS23220 ENOG41068KX affects formate dehydrogenase-N HV304_RS23230 ENOG4105SUU thioesterase domain HV304_RS23235 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HV304_RS23240 ENOG4107S2Z UPF0761 membrane protein HV304_RS23245 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HV304_RS23250 ENOG4105E98 transcriptional regulator DeoR family HV304_RS23255 ENOG4108MGF sugar kinase HV304_RS23260 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV304_RS23265 ENOG4105D2M Aldolase HV304_RS23270 ENOG4107QKS N-acylglucosamine 2-epimerase HV304_RS23275 ENOG4107WI4 Aldose-1-epimerase HV304_RS23280 ENOG4105CJQ hydrolase, family 31 HV304_RS23290 ENOG4105CT4 transporter HV304_RS23295 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HV304_RS23300 ENOG4105CI3 gtp-binding protein typa HV304_RS23305 ENOG4105C5F glutamine synthetase HV304_RS23310 ENOG4105CUX Signal transduction histidine kinase HV304_RS23315 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV304_RS23320 ENOG4106FIY HV304_RS23325 ENOG4105D4P Coproporphyrinogen iii oxidase HV304_RS23340 ENOG4105C2M dna polymerase I HV304_RS23345 ENOG4106HNH Acyl-transferase HV304_RS23350 ENOG4108Z33 Thiol disulfide Interchange Protein HV304_RS23360 ENOG4105PC1 Conserved Protein HV304_RS23365 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV304_RS23370 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV304_RS23400 ENOG4108RR8 protoporphyrinogen oxidase HV304_RS23405 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV304_RS23410 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV304_RS23420 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV304_RS23425 ENOG4105CHU acetyl-coa acetyltransferase HV304_RS23430 ENOG4105ETE Transcriptional regulator (LacI family HV304_RS23435 ENOG4105DKQ ROK family HV304_RS23440 ENOG4107QK7 reductase HV304_RS23445 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV304_RS23450 ENOG4105MDZ Transcriptional activator rfaH HV304_RS23455 ENOG4105F8V Hydrolase, tatD family HV304_RS23460 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV304_RS23465 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV304_RS23470 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV304_RS23480 ENOG4105JC1 sterol-binding domain protein HV304_RS23490 ENOG4105CGY Dna recombination protein HV304_RS23495 ENOG4107SXA Phosphorylase HV304_RS23500 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV304_RS23510 ENOG4105DZ2 Transcriptional regulator HV304_RS23515 ENOG4105EMK carboxylate amino acid amine transporter HV304_RS23520 ENOG4105DQF Hydrolase HV304_RS23525 ENOG4108EUD Lysophospholipase HV304_RS23530 ENOG410829K Lysine exporter protein (Lyse ygga) HV304_RS23540 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV304_RS23545 ENOG4105C9U ATP-dependent DNA helicase RecQ HV304_RS23550 ENOG4105HDD phospholipase HV304_RS23555 ENOG4108VUY thioesterase Superfamily protein HV304_RS23560 ENOG4105FR1 rard protein HV304_RS23565 ENOG4107QUT magnesium and cobalt transport protein CorA HV304_RS23570 ENOG4105C4R Atp-dependent dna helicase HV304_RS23575 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV304_RS23580 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV304_RS23585 ENOG4105CT0 Protein of unknown function, DUF484 HV304_RS23595 ENOG4105S7Z (LipO)protein HV304_RS23605 ENOG4107T0K Adenylate cyclase HV304_RS23615 ENOG41076E6 Uroporphyrinogen-III Synthase HV304_RS23620 ENOG4105ECF c-methyltransferase HV304_RS23625 ENOG410601J HemY protein HV304_RS23650 ENOG4105C85 amino acid HV304_RS23655 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HV304_RS23665 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HV304_RS23670 ENOG4105EGZ biosynthesis protein HV304_RS23675 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV304_RS23680 ENOG4108WJ1 acetyltransferase HV304_RS23685 ENOG4108IJ1 Dehydrogenase HV304_RS23690 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV304_RS23695 ENOG4105SFE lipopolysaccharide biosynthesis protein HV304_RS23700 ENOG4105ESV Glycosyl transferase, family 4 HV304_RS23705 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV304_RS23725 ENOG4105C9X ppx gppa phosphatase HV304_RS23730 ENOG4105C4R Atp-dependent dna helicase HV304_RS23735 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV304_RS23745 ENOG4105EMY transcriptional regulator HV304_RS23750 ENOG4105RKW reductase (By HV304_RS23755 ENOG4105C7B Threonine dehydratase HV304_RS23765 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV304_RS23770 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV304_RS23785 ENOG4105C0P Mg chelatase subunit ChlI HV304_RS23790 ENOG4108WFC UPF0438 protein yifE HV304_RS23830 ENOG4107EJG GntR family transcriptional regulator HV304_RS23835 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV304_RS23840 ENOG4105ETE Transcriptional regulator (LacI family HV304_RS23845 ENOG4108RVA ribokinase HV304_RS23850 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV304_RS23855 ENOG4105CNN ABC, transporter HV304_RS23865 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HV304_RS23880 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HV304_RS23890 ENOG4108VVK transcriptional Regulator, AsnC HV304_RS23895 ENOG4105QTB Flavodoxin HV304_RS23905 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HV304_RS23910 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV304_RS23915 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HV304_RS23925 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV304_RS23930 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV304_RS23935 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HV304_RS23940 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HV304_RS23945 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HV304_RS23950 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HV304_RS23955 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV304_RS23960 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV304_RS23965 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV304_RS23970 ENOG4105C8U phosphate abc transporter HV304_RS23975 ENOG4105E2Z phosphate ABC transporter (Permease HV304_RS23980 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV304_RS23990 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV304_RS23995 ENOG4105C7N Xanthine uracil vitamin C permease HV304_RS24000 ENOG4108YYH Nadph-dependent fmn reductase HV304_RS24005 ENOG4105E8Q phosphopantetheinyl transferase HV304_RS24010 ENOG4105G2Y Transcriptional regulator HV304_RS24020 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HV304_RS24035 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HV304_RS24040 ENOG4105VG0 50S ribosomal protein l34 HV304_RS24090 ENOG4108BUD transposase HV304_RS24095 ENOG4105C7H Helicase, RecD TraA family HV304_RS24120 ENOG4108YXQ IS66 Orf2 family protein HV304_RS24165 ENOG4105F9F transposase HV304_RS24210 ENOG4105F2I Transposase HV304_RS24235 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HV304_RS24245 ENOG4108SF5 RNA Polymerase HV304_RS24250 ENOG4108S3W Anti-feci sigma factor, fecr HV304_RS24255 ENOG4105GAV receptor HV304_RS24260 ENOG4108HUF Transporter HV304_RS24265 ENOG4105DQ5 transport system permease protein HV304_RS24270 ENOG4108IHU transport system permease protein HV304_RS24275 ENOG4105E0A ABC, transporter HV304_RS24280 ENOG4108YXQ IS66 Orf2 family protein HV304_RS24295 ENOG4105ETE Transcriptional regulator (LacI family HV304_RS24305 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV304_RS24320 ENOG4107QN2 dihydrolipoyl dehydrogenase HV304_RS24335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV304_RS24340 ENOG4105D0C transport protein HV304_RS24345 ENOG4105C8Q Methyl-accepting chemotaxis HV304_RS24355 ENOG4105DMF Dehydrogenase HV304_RS24360 ENOG4105F2I Transposase HV304_RS24365 ENOG4105EMU Dehydrogenase HV304_RS24370 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HV304_RS24375 ENOG4108SUT Major Facilitator Superfamily HV304_RS24380 ENOG4105ECQ AraC Family Transcriptional Regulator HV304_RS24385 ENOG4105E7U AraC family transcriptional regulator HV304_RS24410 ENOG4105F9F transposase HV304_RS24430 ENOG4105E5H Transposase HV304_RS24435 ENOG4108YXQ IS66 Orf2 family protein HV304_RS24500 ENOG4105DAX Pfam:DUF2983 HV304_RS24530 ENOG4108M24 von Willebrand factor, type A HV304_RS24555 ENOG4105F9F transposase HV304_RS24580 ENOG4105F2I Transposase HV304_RS24595 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS24690 ENOG4105DH7 May be involved in recombination (By similarity) HV304_RS24700 ENOG4105DFE Dna adenine methylase HV304_RS24705 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV304_RS24850 ENOG4105HVQ Regulatory factor of maltose metabolism HV304_RS24865 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV304_RS24870 ENOG4105KT5 UmuD protein HV304_RS24880 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS24895 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HV304_RS24900 ENOG41080HT Transcriptional regulator, arsr family HV304_RS24920 ENOG4105VYW UPF0251 protein HV304_RS24925 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS24950 ENOG4108X6F Transcriptional regulator MerD HV304_RS24965 ENOG4105XIV Mercuric transport protein, periplasmic component HV304_RS24995 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HV304_RS25025 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS25050 ENOG4105DUM transcriptional regulator, lysR family HV304_RS25055 ENOG41067TZ transcriptional regulator, MarR family HV304_RS25075 ENOG4105E66 phosphoriboisomerase A HV304_RS25090 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HV304_RS25100 ENOG4105F04 LysR family Transcriptional regulator HV304_RS25110 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HV304_RS25115 ENOG4105CYM Glutathione S-transferase HV304_RS25125 ENOG4105D13 transposase HV304_RS25185 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV304_RS25190 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV304_RS25195 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HV304_RS25205 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV304_RS25240 ENOG4108U51 Universal stress protein HV304_RS25245 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV304_RS25250 ENOG4105BZS acriflavin resistance protein HV304_RS25275 ENOG4105XIV Mercuric transport protein, periplasmic component HV304_RS25310 ENOG4108BUD transposase HV304_RS25315 ENOG4108UEC Ferritin-like protein HV304_RS25320 ENOG4108BUD transposase HV304_RS25325 ENOG4105F2I Transposase HV304_RS25340 ENOG4105EQR Transposase IS116 IS110 IS902 HV304_RS25350 ENOG4108BUD transposase HV304_RS25390 ENOG4105DHJ ABC, transporter HV304_RS25405 ENOG4108BUD transposase HV304_RS25435 ENOG4105C3F Signal peptidase i HV304_RS25455 ENOG4105F2I Transposase HV304_RS25490 ENOG4107712 HV304_RS25505 ENOG4108YXQ IS66 Orf2 family protein HV304_RS25570 ENOG4105DVT helicase HV304_RS25770 ENOG4105C2U cobyrinic Acid a,c-diamide synthase HV304_RS25825 ENOG4105CDU Replicative dna helicase HV304_RS25920 ENOG4106JVB Replication Protein HV304_RS25935 ENOG4105WJ3 XRE family Transcriptional regulator HV304_RS26115 ENOG4107QJE Chromosome Partitioning Protein HV304_RS26275 ENOG4107YCR Transcriptional regulator, ARSR family HV304_RS26280 ENOG4105PGM cation diffusion facilitator family transporter