locus-tag	class	description
HV304_RS00010	COG0592	DNA-directed DNA polymerase activity
HV304_RS00025	COG0561	phosphatase activity
HV304_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV304_RS00040	COG5645	(Lipo)protein
HV304_RS00060	COG2149	membrane
HV304_RS00070	COG0641	radical SAM
HV304_RS00080	COG2610	gluconate transmembrane transporter activity
HV304_RS00095	COG2814	Major facilitator Superfamily
HV304_RS00115	COG0028	Belongs to the TPP enzyme family
HV304_RS00120	COG0440	acetolactate synthase activity
HV304_RS00125	COG1349	DNA-binding transcription factor activity
HV304_RS00135	COG0738	Major facilitator superfamily
HV304_RS00145	COG2197	response regulator
HV304_RS00175	COG3620	sequence-specific DNA binding
HV304_RS00185	COG2723	6-phospho-beta-galactosidase activity
HV304_RS00210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS00210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS00215	COG3715	PTS system
HV304_RS00220	COG3716	PTS system mannose fructose sorbose family IID component
HV304_RS00235	COG5464	transposase or invertase
HV304_RS00240	COG1464	Belongs to the NlpA lipoprotein family
HV304_RS00245	COG0697	spore germination
HV304_RS00255	COG0604	alcohol dehydrogenase
HV304_RS00260	COG0583	DNA-binding transcription factor activity
HV304_RS00280	COG3039	Transposase
HV304_RS00335	COG1192	Involved in chromosome partitioning
HV304_RS00340	COG0582	viral genome integration into host DNA
HV304_RS00350	COG2211	Major facilitator Superfamily
HV304_RS00355	COG1501	Belongs to the glycosyl hydrolase 31 family
HV304_RS00360	COG3711	transcriptional antiterminator
HV304_RS00365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS00365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS00365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS00370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS00375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS00375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS00385	COG0191	fructose-bisphosphate aldolase activity
HV304_RS00395	COG2982	Protein involved in outer membrane biogenesis
HV304_RS00400	COG2233	PERMEase
HV304_RS00405	COG0786	glutamate:sodium symporter activity
HV304_RS00410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV304_RS00415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV304_RS00420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV304_RS00440	COG2860	membrane
HV304_RS00445	COG1561	YicC-like family, N-terminal region
HV304_RS00470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV304_RS00485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV304_RS00500	COG1519	Transferase
HV304_RS00505	COG0859	PFAM glycosyl transferase family 9
HV304_RS00510	COG0438	transferase activity, transferring glycosyl groups
HV304_RS00515	COG0515	serine threonine protein kinase
HV304_RS00530	COG1442	glycosyl transferase family 8
HV304_RS00535	COG3306	glycosyltransferase involved in LPS biosynthesis
HV304_RS00540	COG3307	-O-antigen
HV304_RS00550	COG0859	PFAM glycosyl transferase family 9
HV304_RS00560	COG0156	8-amino-7-oxononanoate synthase activity
HV304_RS00570	COG1216	Glycosyl transferase, family 2
HV304_RS00575	COG2861	carbohydrate metabolic process
HV304_RS00580	COG4942	peptidase
HV304_RS00590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV304_RS00595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV304_RS00610	COG1045	serine acetyltransferase
HV304_RS00615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV304_RS00620	COG2271	Major facilitator Superfamily
HV304_RS00630	COG2186	Transcriptional regulator
HV304_RS00650	COG3722	fumarate hydratase activity
HV304_RS00660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS00660	COG2213	PTS system mannitol-specific
HV304_RS00670	COG1566	PFAM secretion protein HlyD family protein
HV304_RS00675	COG0625	glutathione transferase activity
HV304_RS00685	COG3276	selenocysteine insertion sequence binding
HV304_RS00690	COG1454	alcohol dehydrogenase
HV304_RS00695	COG1012	belongs to the aldehyde dehydrogenase family
HV304_RS00710	COG1566	PFAM secretion protein HlyD family protein
HV304_RS00715	COG0583	DNA-binding transcription factor activity
HV304_RS00720	COG3713	MltA-interacting MipA family protein
HV304_RS00730	COG2211	Major facilitator Superfamily
HV304_RS00735	COG4977	sequence-specific DNA binding
HV304_RS00735	COG1917	Cupin 2, conserved barrel domain protein
HV304_RS00740	COG0235	Class ii aldolase
HV304_RS00745	COG3623	hexulose-6-phosphate isomerase
HV304_RS00750	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV304_RS00755	COG1070	Carbohydrate kinase
HV304_RS00760	COG2271	Major facilitator Superfamily
HV304_RS00770	COG2731	YhcH YjgK YiaL family protein
HV304_RS00780	COG1414	Transcriptional regulator
HV304_RS00785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV304_RS00790	COG3977	Valine--pyruvate aminotransferase
HV304_RS00795	COG0366	Alpha amylase catalytic
HV304_RS00800	COG2992	FlgJ-related protein
HV304_RS00805	COG1609	Transcriptional regulator
HV304_RS00805	COG2207	Transcriptional regulator
HV304_RS00815	COG1070	Carbohydrate kinase
HV304_RS00820	COG4682	membrane
HV304_RS00825	COG3274	enterobacterial common antigen metabolic process
HV304_RS00850	COG1278	Cold shock
HV304_RS00855	COG2944	sequence-specific DNA binding
HV304_RS00875	COG2814	Major facilitator Superfamily
HV304_RS00880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS00890	COG1609	Transcriptional regulator
HV304_RS00895	COG2885	chlorophyll binding
HV304_RS00900	COG0243	molybdopterin cofactor binding
HV304_RS00905	COG0456	acetyltransferase
HV304_RS00910	COG2818	Glycosylase
HV304_RS00915	COG5571	outer membrane autotransporter
HV304_RS00920	COG2223	nitrite transmembrane transporter activity
HV304_RS00965	COG0747	negative chemotaxis
HV304_RS00970	COG0601	transmembrane transport
HV304_RS00975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV304_RS00980	COG0444	Belongs to the ABC transporter superfamily
HV304_RS00985	COG4608	Belongs to the ABC transporter superfamily
HV304_RS00990	COG2204	response regulator
HV304_RS00995	COG0814	amino acid
HV304_RS01010	COG2199	diguanylate cyclase activity
HV304_RS01010	COG2200	EAL domain
HV304_RS01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS01030	COG2200	EAL domain
HV304_RS01035	COG2982	Protein involved in outer membrane biogenesis
HV304_RS01040	COG0477	Major facilitator Superfamily
HV304_RS01045	COG1295	ribonuclease BN
HV304_RS01050	COG0583	DNA-binding transcription factor activity
HV304_RS01055	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS01065	COG2200	EAL domain
HV304_RS01070	COG2197	response regulator
HV304_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV304_RS01095	COG1858	cytochrome C peroxidase
HV304_RS01105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV304_RS01110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV304_RS01115	COG0339	signal peptide processing
HV304_RS01130	COG1959	2 iron, 2 sulfur cluster binding
HV304_RS01140	COG0589	response to stress
HV304_RS01150	COG0306	phosphate transporter
HV304_RS01155	COG2081	HI0933 family
HV304_RS01165	COG3039	Transposase
HV304_RS01175	COG2239	Acts as a magnesium transporter
HV304_RS01180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV304_RS01185	COG1129	ABC transporter
HV304_RS01185	COG0842	Transport permease protein
HV304_RS01190	COG0842	Transport permease protein
HV304_RS01210	COG2091	lysine biosynthetic process via aminoadipic acid
HV304_RS01215	COG0628	permease
HV304_RS01220	COG0477	Major facilitator Superfamily
HV304_RS01230	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV304_RS01245	COG3714	YhhN family
HV304_RS01270	COG3776	membrane
HV304_RS01275	COG0742	ribosomal rna small subunit methyltransferase
HV304_RS01280	COG0552	protein localization to endoplasmic reticulum
HV304_RS01285	COG2884	Cell division ATP-binding protein ftsE
HV304_RS01290	COG2177	Part of the ABC transporter FtsEX involved in
HV304_RS01315	COG0683	leucine binding
HV304_RS01325	COG4177	L-phenylalanine transmembrane transporter activity
HV304_RS01330	COG0411	ABC transporter
HV304_RS01365	COG0584	glycerophosphoryl diester phosphodiesterase
HV304_RS01375	COG0405	Gamma-glutamyltransferase
HV304_RS01380	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HV304_RS01395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS01405	COG1247	-acetyltransferase
HV304_RS01410	COG0673	inositol 2-dehydrogenase activity
HV304_RS01415	COG1741	Belongs to the pirin family
HV304_RS01420	COG1609	Transcriptional regulator
HV304_RS01425	COG3265	gluconokinase activity
HV304_RS01430	COG2610	gluconate transmembrane transporter activity
HV304_RS01445	COG2095	MarC family integral membrane protein
HV304_RS01450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV304_RS01475	COG0058	SHG alpha-glucan phosphorylase activity
HV304_RS01480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV304_RS01495	COG1349	DNA-binding transcription factor activity
HV304_RS01505	COG0058	SHG alpha-glucan phosphorylase activity
HV304_RS01510	COG1640	4-alpha-glucanotransferase
HV304_RS01515	COG2610	gluconate transmembrane transporter activity
HV304_RS01525	COG1040	competence protein
HV304_RS01535	COG5464	transposase or invertase
HV304_RS01550	COG1918	ferrous iron import across plasma membrane
HV304_RS01555	COG2183	response to ionizing radiation
HV304_RS01560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV304_RS01565	COG0745	RESPONSE REGULATOR receiver
HV304_RS01590	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV304_RS01600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV304_RS01605	COG1011	Hydrolase
HV304_RS01615	COG0494	nUDIX hydrolase
HV304_RS01620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV304_RS01625	COG4972	Pilus assembly protein
HV304_RS01630	COG3166	PFAM Fimbrial assembly family protein
HV304_RS01645	COG4796	Type ii and iii secretion system protein
HV304_RS01660	COG3266	domain, Protein
HV304_RS01665	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV304_RS01670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV304_RS01680	COG0180	Tryptophanyl-tRNA synthetase
HV304_RS01685	COG2188	Transcriptional regulator
HV304_RS01695	COG3457	Alanine racemase
HV304_RS01700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HV304_RS01705	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HV304_RS01720	COG0626	cystathionine gamma-synthase activity
HV304_RS01740	COG2146	nitrite reductase [NAD(P)H] activity
HV304_RS01745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV304_RS01770	COG0512	Glutamine amidotransferase of anthranilate synthase
HV304_RS01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV304_RS01780	COG1289	transmembrane transporter activity
HV304_RS01790	COG1765	OsmC-like protein
HV304_RS01795	COG3954	Phosphoribulokinase
HV304_RS01805	COG0429	hydrolase of the alpha beta-hydrolase fold
HV304_RS01815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HV304_RS01825	COG0488	(ABC) transporter
HV304_RS01840	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV304_RS01845	COG1047	Peptidyl-prolyl cis-trans
HV304_RS01855	COG0545	Peptidyl-prolyl cis-trans isomerase
HV304_RS01860	COG2964	Protein conserved in bacteria
HV304_RS01885	COG0049	tRNA binding
HV304_RS01915	COG0051	transcription antitermination factor activity, RNA binding
HV304_RS01925	COG0088	Forms part of the polypeptide exit tunnel
HV304_RS01940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV304_RS02015	COG0200	Binds to the 23S rRNA
HV304_RS02020	COG0201	protein transport
HV304_RS02035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV304_RS02060	COG0789	Transcriptional regulator
HV304_RS02065	COG3036	rescue of stalled ribosome
HV304_RS02075	COG0569	domain protein
HV304_RS02095	COG0758	DNA mediated transformation
HV304_RS02105	COG0551	DNA topoisomerase type I activity
HV304_RS02125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV304_RS02165	COG1126	abc transporter atp-binding protein
HV304_RS02170	COG0765	amino acid transport
HV304_RS02175	COG4597	amino acid ABC transporter
HV304_RS02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV304_RS02190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV304_RS02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV304_RS02200	COG1309	transcriptional regulator
HV304_RS02210	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV304_RS02235	COG4145	pantothenate transmembrane transporter activity
HV304_RS02240	COG3924	membrane
HV304_RS02245	COG0439	Biotin carboxylase
HV304_RS02250	COG0511	ligase activity, forming carbon-carbon bonds
HV304_RS02265	COG0604	alcohol dehydrogenase
HV304_RS02270	COG2200	EAL domain
HV304_RS02270	COG2199	diguanylate cyclase activity
HV304_RS02280	COG1077	Cell shape determining protein MreB Mrl
HV304_RS02285	COG1792	Involved in formation and maintenance of cell shape
HV304_RS02290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV304_RS02300	COG1530	ribonuclease E activity
HV304_RS02305	COG3164	Protein of unknown function
HV304_RS02310	COG0312	modulator of DNA gyrase
HV304_RS02315	COG0583	DNA-binding transcription factor activity
HV304_RS02335	COG2732	(Barnase) inhibitor
HV304_RS02355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV304_RS02360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV304_RS02365	COG3105	Protein conserved in bacteria
HV304_RS02370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV304_RS02385	COG0625	glutathione transferase activity
HV304_RS02390	COG2969	positive regulation of protein catabolic process
HV304_RS02395	COG3069	C4-dicarboxylate transmembrane transporter activity
HV304_RS02420	COG2731	YhcH YjgK YiaL family protein
HV304_RS02425	COG0402	S-adenosylhomocysteine deaminase activity
HV304_RS02430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV304_RS02435	COG4804	nuclease activity
HV304_RS02440	COG0493	'glutamate synthase
HV304_RS02445	COG0067	glutamate synthase
HV304_RS02445	COG0070	glutamate synthase
HV304_RS02445	COG0069	glutamate synthase activity
HV304_RS02450	COG1242	4 iron, 4 sulfur cluster binding
HV304_RS02455	COG2198	Histidine kinase
HV304_RS02455	COG0784	Response regulator, receiver
HV304_RS02455	COG5002	protein histidine kinase activity
HV304_RS02460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV304_RS02470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS02485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV304_RS02495	COG1137	ATPase activity
HV304_RS02500	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV304_RS02505	COG3117	lipopolysaccharide transmembrane transporter activity
HV304_RS02510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV304_RS02520	COG0530	calcium, potassium:sodium antiporter activity
HV304_RS02525	COG1127	ABC transporter
HV304_RS02530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV304_RS02535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV304_RS02540	COG2854	intermembrane phospholipid transfer
HV304_RS02545	COG3113	response to antibiotic
HV304_RS02550	COG5007	Belongs to the BolA IbaG family
HV304_RS02560	COG3423	Transcriptional regulator
HV304_RS02565	COG0142	geranyltranstransferase activity
HV304_RS02570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV304_RS02575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV304_RS02580	COG0697	spore germination
HV304_RS02590	COG2027	D-alanyl-D-alanine carboxypeptidase
HV304_RS02600	COG1534	Rna-binding protein
HV304_RS02610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV304_RS02615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV304_RS02625	COG3069	C4-dicarboxylate transmembrane transporter activity
HV304_RS02630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV304_RS02635	COG0583	DNA-binding transcription factor activity
HV304_RS02640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV304_RS02665	COG0195	Participates in both transcription termination and antitermination
HV304_RS02670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV304_RS02675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV304_RS02705	COG0513	Belongs to the DEAD box helicase family
HV304_RS02710	COG0814	amino acid
HV304_RS02715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV304_RS02720	COG0826	peptidase U32
HV304_RS02725	COG0826	peptidase U32
HV304_RS02730	COG3154	lipid carrier protein
HV304_RS02735	COG3153	acetyltransferase
HV304_RS02750	COG0702	epimerase
HV304_RS02755	COG2823	Periplasmic or secreted lipoprotein
HV304_RS02775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV304_RS02785	COG2222	sugar isomerase
HV304_RS02790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV304_RS02795	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS02800	COG3716	PTS system mannose fructose sorbose family IID component
HV304_RS02810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS02820	COG1349	DNA-binding transcription factor activity
HV304_RS02825	COG1349	DNA-binding transcription factor activity
HV304_RS02830	COG1940	carbohydrate kinase activity
HV304_RS02835	COG0673	inositol 2-dehydrogenase activity
HV304_RS02840	COG3842	ATPase activity
HV304_RS02845	COG0395	ABC-type sugar transport system, permease component
HV304_RS02850	COG1175	transmembrane transport
HV304_RS02860	COG2721	sulfolactate sulfo-lyase activity
HV304_RS02865	COG2271	Major facilitator Superfamily
HV304_RS02875	COG2084	Dehydrogenase
HV304_RS02880	COG1929	Belongs to the glycerate kinase type-1 family
HV304_RS02925	COG0583	DNA-binding transcription factor activity
HV304_RS02945	COG1882	Formate acetyltransferase
HV304_RS02950	COG0251	oxidation-reduction process
HV304_RS02955	COG1760	l-serine dehydratase
HV304_RS02960	COG0814	amino acid
HV304_RS02975	COG1741	Belongs to the pirin family
HV304_RS02980	COG0583	DNA-binding transcription factor activity
HV304_RS02985	COG3152	Membrane
HV304_RS02990	COG0435	Glutathione S-transferase
HV304_RS02995	COG2259	Doxx family
HV304_RS03005	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV304_RS03010	COG4575	ribosome binding
HV304_RS03015	COG1422	Protein of unknown function (DUF1090)
HV304_RS03025	COG0586	Pfam SNARE associated Golgi protein
HV304_RS03030	COG2186	Transcriptional regulator
HV304_RS03035	COG2271	Major facilitator Superfamily
HV304_RS03045	COG2721	sulfolactate sulfo-lyase activity
HV304_RS03065	COG0673	inositol 2-dehydrogenase activity
HV304_RS03070	COG1451	nucleotide metabolic process
HV304_RS03080	COG1902	pentaerythritol trinitrate reductase activity
HV304_RS03080	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV304_RS03085	COG3408	Glycogen debranching enzyme
HV304_RS03085	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HV304_RS03095	COG0531	amino acid
HV304_RS03100	COG2731	YhcH YjgK YiaL family protein
HV304_RS03105	COG3250	beta-galactosidase activity
HV304_RS03110	COG1609	Transcriptional regulator
HV304_RS03115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV304_RS03125	COG0840	transmembrane signaling receptor activity
HV304_RS03130	COG1695	Transcriptional regulator
HV304_RS03135	COG2375	cellular response to nickel ion
HV304_RS03145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV304_RS03235	COG4983	Phage plasmid primase, P4 family domain protein
HV304_RS03260	COG1061	Type III restriction enzyme res subunit
HV304_RS03270	COG3596	GTP binding
HV304_RS03280	COG2378	regulation of single-species biofilm formation
HV304_RS03305	COG2003	Belongs to the UPF0758 family
HV304_RS03340	COG4771	TonB-dependent receptor
HV304_RS03345	COG3391	amine dehydrogenase activity
HV304_RS03355	COG0358	DNA primase activity
HV304_RS03360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV304_RS03365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV304_RS03370	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV304_RS03380	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV304_RS03410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS03415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS03430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV304_RS03445	COG4991	sh3 domain protein
HV304_RS03450	COG3025	triphosphatase activity
HV304_RS03465	COG2268	Band 7 protein
HV304_RS03470	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV304_RS03510	COG3384	dioxygenase
HV304_RS03515	COG0754	glutathionylspermidine amidase activity
HV304_RS03525	COG1538	Outer membrane efflux protein
HV304_RS03530	COG0494	nUDIX hydrolase
HV304_RS03535	COG3151	Protein conserved in bacteria
HV304_RS03540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV304_RS03545	COG3150	esterase
HV304_RS03550	COG0187	DNA topoisomerase II activity
HV304_RS03555	COG1917	Cupin 2, conserved barrel domain protein
HV304_RS03555	COG4977	sequence-specific DNA binding
HV304_RS03565	COG2211	Major facilitator Superfamily
HV304_RS03570	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV304_RS03575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV304_RS03580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV304_RS03595	COG3111	PFAM Bacterial OB fold (BOF) protein
HV304_RS03615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV304_RS03630	COG0471	metal ion transport
HV304_RS03635	COG0656	L-ascorbic acid biosynthetic process
HV304_RS03640	COG1979	alcohol dehydrogenase
HV304_RS03645	COG2207	Transcriptional regulator
HV304_RS03650	COG0586	Pfam SNARE associated Golgi protein
HV304_RS03655	COG0626	cystathionine gamma-synthase activity
HV304_RS03665	COG0848	biopolymer transport protein
HV304_RS03685	COG0667	Aldo Keto reductase
HV304_RS03695	COG0840	transmembrane signaling receptor activity
HV304_RS03705	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV304_RS03710	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS03715	COG5557	Pfam Polysulphide reductase, NrfD
HV304_RS03720	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV304_RS03725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV304_RS03730	COG1773	rubredoxin
HV304_RS03740	COG0298	carbon dioxide binding
HV304_RS03745	COG0625	glutathione transferase activity
HV304_RS03750	COG0243	molybdopterin cofactor binding
HV304_RS03755	COG0754	glutathionylspermidine amidase activity
HV304_RS03790	COG2003	Belongs to the UPF0758 family
HV304_RS03820	COG2378	regulation of single-species biofilm formation
HV304_RS03830	COG3596	GTP binding
HV304_RS03855	COG1294	oxidase, subunit
HV304_RS03880	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HV304_RS03905	COG3039	Transposase
HV304_RS03910	COG5001	Diguanylate cyclase
HV304_RS03920	COG0840	transmembrane signaling receptor activity
HV304_RS03935	COG2826	transposase and inactivated derivatives, IS30 family
HV304_RS03955	COG0582	viral genome integration into host DNA
HV304_RS03970	COG1982	Orn Lys Arg decarboxylase major
HV304_RS03975	COG2211	Major facilitator Superfamily
HV304_RS03990	COG1194	a g-specific adenine glycosylase
HV304_RS04000	COG3171	Protein conserved in bacteria
HV304_RS04010	COG0252	asparaginase activity
HV304_RS04015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV304_RS04030	COG0762	integral membrane protein
HV304_RS04035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV304_RS04040	COG2805	Type II/IV secretion system protein
HV304_RS04055	COG0189	ligase activity
HV304_RS04060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV304_RS04065	COG2356	endonuclease I
HV304_RS04070	COG3091	SprT-like family
HV304_RS04075	COG2814	Major facilitator Superfamily
HV304_RS04095	COG1166	arginine decarboxylase activity
HV304_RS04105	COG0501	Belongs to the peptidase M48B family
HV304_RS04110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV304_RS04115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS04120	COG2213	PTS system mannitol-specific
HV304_RS04125	COG1063	alcohol dehydrogenase
HV304_RS04130	COG1494	fructose-1,6-bisphosphatase
HV304_RS04140	COG1072	(Pantothenic acid kinase))
HV304_RS04150	COG1122	ATPase activity
HV304_RS04180	COG0191	fructose-bisphosphate aldolase activity
HV304_RS04185	COG0668	transmembrane transport
HV304_RS04190	COG1279	arginine transmembrane transporter activity
HV304_RS04195	COG2968	Membrane
HV304_RS04200	COG0583	DNA-binding transcription factor activity
HV304_RS04205	COG0427	acetyl-CoA hydrolase
HV304_RS04210	COG1024	Enoyl-CoA hydratase
HV304_RS04215	COG1703	isobutyryl-CoA mutase activity
HV304_RS04220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV304_RS04220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV304_RS04235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV304_RS04240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV304_RS04260	COG0006	proline dipeptidase activity
HV304_RS04265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV304_RS04270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV304_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS04295	COG2723	6-phospho-beta-galactosidase activity
HV304_RS04300	COG1737	Transcriptional regulator
HV304_RS04310	COG1272	protein, Hemolysin III
HV304_RS04320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV304_RS04345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV304_RS04365	COG4942	peptidase
HV304_RS04375	COG0582	viral genome integration into host DNA
HV304_RS04405	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV304_RS04435	COG0739	heme binding
HV304_RS04445	COG2132	Multicopper oxidase
HV304_RS04450	COG3667	copper resistance
HV304_RS04455	COG2372	response to copper ion
HV304_RS04460	COG1276	copper resistance
HV304_RS04465	COG0745	RESPONSE REGULATOR receiver
HV304_RS04470	COG2205	protein histidine kinase activity
HV304_RS04505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV304_RS04510	COG1393	Belongs to the ArsC family
HV304_RS04525	COG1396	sequence-specific DNA binding
HV304_RS04535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV304_RS04565	COG3596	GTP binding
HV304_RS04575	COG2378	regulation of single-species biofilm formation
HV304_RS04605	COG2003	Belongs to the UPF0758 family
HV304_RS04630	COG3039	Transposase
HV304_RS04635	COG0457	Tetratricopeptide repeat
HV304_RS04640	COG1649	PFAM Uncharacterised BCR, COG1649
HV304_RS04640	COG0726	polysaccharide deacetylase
HV304_RS04645	COG1215	transferase activity, transferring glycosyl groups
HV304_RS04655	COG3592	Divergent 4Fe-4S mono-cluster
HV304_RS04660	COG2388	GCN5-related N-acetyl-transferase
HV304_RS04665	COG0583	DNA-binding transcription factor activity
HV304_RS04670	COG0666	response to abiotic stimulus
HV304_RS04680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV304_RS04685	COG1304	FMN binding
HV304_RS04695	COG0549	Belongs to the carbamate kinase family
HV304_RS04700	COG0402	S-adenosylhomocysteine deaminase activity
HV304_RS04715	COG0814	amino acid
HV304_RS04730	COG0183	Belongs to the thiolase family
HV304_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS04745	COG2814	Major facilitator Superfamily
HV304_RS04750	COG5464	transposase or invertase
HV304_RS04760	COG1794	racemase activity, acting on amino acids and derivatives
HV304_RS04765	COG0583	DNA-binding transcription factor activity
HV304_RS04775	COG1609	Transcriptional regulator
HV304_RS04795	COG0667	Aldo Keto reductase
HV304_RS04805	COG0861	Integral membrane protein TerC family
HV304_RS04835	COG2165	general secretion pathway protein
HV304_RS04840	COG4795	General secretion pathway protein
HV304_RS04850	COG4967	type IV pilus modification protein PilV
HV304_RS04855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV304_RS04865	COG1074	ATP-dependent DNA helicase activity
HV304_RS04870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV304_RS04875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV304_RS04875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV304_RS04880	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV304_RS04910	COG3121	Chaperone
HV304_RS04915	COG3188	usher protein
HV304_RS04950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV304_RS04955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV304_RS04960	COG2166	iron-sulfur cluster assembly
HV304_RS04965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV304_RS04975	COG0583	DNA-binding transcription factor activity
HV304_RS04980	COG2363	Small membrane protein
HV304_RS04990	COG1349	DNA-binding transcription factor activity
HV304_RS05000	COG1070	Carbohydrate kinase
HV304_RS05010	COG1129	ABC transporter
HV304_RS05015	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV304_RS05025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV304_RS05035	COG0235	Class ii aldolase
HV304_RS05040	COG1454	alcohol dehydrogenase
HV304_RS05050	COG1760	l-serine dehydratase
HV304_RS05055	COG0814	amino acid
HV304_RS05060	COG1611	Belongs to the LOG family
HV304_RS05075	COG3098	single-species biofilm formation
HV304_RS05080	COG0564	pseudouridine synthase activity
HV304_RS05085	COG0716	FMN binding
HV304_RS05090	COG2271	Major facilitator Superfamily
HV304_RS05095	COG4948	Mandelate Racemase Muconate Lactonizing
HV304_RS05100	COG4948	Mandelate Racemase Muconate Lactonizing
HV304_RS05105	COG1929	Belongs to the glycerate kinase type-1 family
HV304_RS05110	COG4999	Histidine kinase
HV304_RS05110	COG3850	Histidine kinase
HV304_RS05110	COG3437	response regulator, receiver
HV304_RS05110	COG2205	protein histidine kinase activity
HV304_RS05120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV304_RS05125	COG3956	TIGRFAM MazG family protein
HV304_RS05140	COG1737	Transcriptional regulator
HV304_RS05145	COG2190	(PTS) system
HV304_RS05145	COG1263	PTS System
HV304_RS05145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS05150	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV304_RS05155	COG0602	queuosine metabolic process
HV304_RS05160	COG0720	synthase
HV304_RS05180	COG2234	aminopeptidase activity
HV304_RS05235	COG1388	LysM domain
HV304_RS05235	COG4942	peptidase
HV304_RS05250	COG0163	prenyltransferase activity
HV304_RS05255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV304_RS05295	COG0210	DNA helicase
HV304_RS05365	COG0628	permease
HV304_RS05370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV304_RS05390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV304_RS05395	COG1882	Formate acetyltransferase
HV304_RS05410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV304_RS05415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV304_RS05420	COG1121	(ABC) transporter
HV304_RS05440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV304_RS05445	COG1737	Transcriptional regulator
HV304_RS05450	COG3069	C4-dicarboxylate transmembrane transporter activity
HV304_RS05470	COG0309	Hydrogenase expression formation protein (HypE)
HV304_RS05475	COG0409	Hydrogenase expression formation protein
HV304_RS05480	COG0298	carbon dioxide binding
HV304_RS05485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV304_RS05490	COG0375	protein maturation
HV304_RS05500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV304_RS05505	COG0651	ATP synthesis coupled electron transport
HV304_RS05510	COG0650	Formate hydrogenlyase subunit 4
HV304_RS05515	COG3261	NADH dehydrogenase
HV304_RS05515	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV304_RS05520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV304_RS05525	COG3260	NADH ubiquinone oxidoreductase 20
HV304_RS05535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV304_RS05545	COG2723	6-phospho-beta-galactosidase activity
HV304_RS05550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS05550	COG1263	PTS System
HV304_RS05555	COG1609	Transcriptional regulator
HV304_RS05560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV304_RS05565	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV304_RS05585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV304_RS05585	COG0517	IMP dehydrogenase activity
HV304_RS05590	COG1349	DNA-binding transcription factor activity
HV304_RS05595	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS05610	COG3732	PTS system glucitol sorbitol-specific
HV304_RS05615	COG3730	PTS system glucitol sorbitol-specific
HV304_RS05620	COG2951	lytic endotransglycosylase activity
HV304_RS05625	COG1546	Belongs to the CinA family
HV304_RS05645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV304_RS05675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV304_RS05680	COG1238	metal cluster binding
HV304_RS05700	COG2814	Major facilitator Superfamily
HV304_RS05705	COG1566	PFAM secretion protein HlyD family protein
HV304_RS05710	COG1846	Transcriptional regulator
HV304_RS05720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV304_RS05725	COG2814	Major facilitator Superfamily
HV304_RS05735	COG4176	ABC-type proline glycine betaine transport system permease component
HV304_RS05775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV304_RS05805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV304_RS05810	COG0640	Transcriptional regulator
HV304_RS05815	COG0401	homolog of Blt101
HV304_RS05820	COG1652	LysM domain
HV304_RS05825	COG1802	Transcriptional regulator
HV304_RS05830	COG1113	amino acid transport
HV304_RS05835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV304_RS05840	COG1012	belongs to the aldehyde dehydrogenase family
HV304_RS05845	COG0579	oxidoreductase
HV304_RS05855	COG1285	pathogenesis
HV304_RS05860	COG2211	Major facilitator Superfamily
HV304_RS05905	COG0642	Histidine kinase
HV304_RS05915	COG3188	usher protein
HV304_RS05920	COG3121	Chaperone
HV304_RS05975	COG0438	transferase activity, transferring glycosyl groups
HV304_RS05980	COG0438	transferase activity, transferring glycosyl groups
HV304_RS05980	COG0297	glycogen (starch) synthase activity
HV304_RS06020	COG3039	Transposase
HV304_RS06035	COG4983	Phage plasmid primase, P4 family domain protein
HV304_RS06040	COG3311	Transcriptional regulator
HV304_RS06080	COG0582	viral genome integration into host DNA
HV304_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV304_RS06115	COG2867	negative regulation of translational initiation
HV304_RS06130	COG0497	DNA recombination
HV304_RS06145	COG4536	flavin adenine dinucleotide binding
HV304_RS06150	COG4137	Cytochrome C assembly protein
HV304_RS06155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV304_RS06180	COG2885	chlorophyll binding
HV304_RS06185	COG2199	diguanylate cyclase activity
HV304_RS06200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV304_RS06205	COG1605	Chorismate mutase
HV304_RS06205	COG0287	Prephenate dehydrogenase
HV304_RS06210	COG1605	Chorismate mutase
HV304_RS06210	COG0077	Prephenate dehydratase
HV304_RS06220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV304_RS06225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV304_RS06240	COG0542	response to heat
HV304_RS06265	COG0477	Major facilitator Superfamily
HV304_RS06270	COG5544	Lipoprotein
HV304_RS06275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV304_RS06290	COG3118	belongs to the thioredoxin family
HV304_RS06295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV304_RS06320	COG0513	Belongs to the DEAD box helicase family
HV304_RS06330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV304_RS06340	COG1595	DNA-templated transcription, initiation
HV304_RS06345	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV304_RS06350	COG3026	antisigma factor binding
HV304_RS06355	COG3086	response to oxidative stress
HV304_RS06365	COG0681	Belongs to the peptidase S26 family
HV304_RS06385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV304_RS06395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV304_RS06400	COG1737	Transcriptional regulator
HV304_RS06405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV304_RS06410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS06410	COG1263	PTS System
HV304_RS06415	COG0560	Phosphoserine phosphatase
HV304_RS06435	COG2205	protein histidine kinase activity
HV304_RS06440	COG3170	Tfp pilus assembly protein FimV
HV304_RS06445	COG2204	response regulator
HV304_RS06450	COG0347	Belongs to the P(II) protein family
HV304_RS06455	COG1017	nitric oxide dioxygenase activity
HV304_RS06455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV304_RS06485	COG4638	Rieske (2fe-2S)
HV304_RS06490	COG0583	DNA-binding transcription factor activity
HV304_RS06495	COG1940	carbohydrate kinase activity
HV304_RS06500	COG0457	Tetratricopeptide repeat
HV304_RS06505	COG0477	Major facilitator Superfamily
HV304_RS06505	COG2814	Major facilitator Superfamily
HV304_RS06515	COG2814	Major facilitator Superfamily
HV304_RS06520	COG3711	transcriptional antiterminator
HV304_RS06525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV304_RS06525	COG0517	IMP dehydrogenase activity
HV304_RS06530	COG1069	ribulokinase activity
HV304_RS06540	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV304_RS06545	COG1129	ABC transporter
HV304_RS06555	COG3683	transport system, periplasmic component
HV304_RS06560	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV304_RS06580	COG1104	cysteine desulfurase activity
HV304_RS06585	COG0822	iron-sulfur transferase activity
HV304_RS06605	COG0633	Ferredoxin
HV304_RS06610	COG2975	iron-sulfur cluster assembly
HV304_RS06625	COG2897	thiosulfate sulfurtransferase activity
HV304_RS06630	COG2373	Large extracellular alpha-helical protein
HV304_RS06635	COG4953	penicillin-binding protein 1C
HV304_RS06665	COG2976	Protein conserved in bacteria
HV304_RS06680	COG3104	oligopeptide transport
HV304_RS06690	COG1645	bacterial-type flagellum-dependent swarming motility
HV304_RS06715	COG0516	GMP reductase activity
HV304_RS06715	COG0517	IMP dehydrogenase activity
HV304_RS06725	COG0668	transmembrane transport
HV304_RS06735	COG2200	EAL domain
HV304_RS06740	COG0248	Ppx GppA phosphatase
HV304_RS06750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV304_RS06760	COG2723	6-phospho-beta-galactosidase activity
HV304_RS06770	COG2233	PERMEase
HV304_RS06780	COG1393	Belongs to the ArsC family
HV304_RS06785	COG4783	chaperone-mediated protein folding
HV304_RS06790	COG0628	permease
HV304_RS06795	COG3366	ferrous iron transmembrane transporter activity
HV304_RS06800	COG0700	Nucleoside recognition
HV304_RS06805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV304_RS06810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV304_RS06815	COG2716	regulation of RNA biosynthetic process
HV304_RS06825	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV304_RS06835	COG2321	neutral zinc metallopeptidase
HV304_RS06845	COG0400	carboxylic ester hydrolase activity
HV304_RS06860	COG1393	Belongs to the ArsC family
HV304_RS06870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV304_RS06875	COG3850	Histidine kinase
HV304_RS06880	COG0493	'glutamate synthase
HV304_RS06880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV304_RS06890	COG5342	invasion associated locus B
HV304_RS06895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV304_RS06915	COG4766	ethanolamine catabolic process
HV304_RS06920	COG4812	Cobalamin adenosyltransferase
HV304_RS06980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HV304_RS06985	COG2207	Transcriptional regulator
HV304_RS06995	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV304_RS07015	COG2837	iron assimilation
HV304_RS07030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV304_RS07035	COG4208	sulfate ABC transporter
HV304_RS07040	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV304_RS07105	COG3530	Putative quorum-sensing-regulated virulence factor
HV304_RS07110	COG0385	Bile acid
HV304_RS07115	COG0583	DNA-binding transcription factor activity
HV304_RS07125	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV304_RS07130	COG2211	Major facilitator Superfamily
HV304_RS07140	COG0583	DNA-binding transcription factor activity
HV304_RS07175	COG3415	Transposase
HV304_RS07180	COG3415	Transposase
HV304_RS07195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV304_RS07210	COG0667	Aldo Keto reductase
HV304_RS07215	COG3961	Belongs to the TPP enzyme family
HV304_RS07230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS07235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS07240	COG0006	proline dipeptidase activity
HV304_RS07245	COG1363	Peptidase, m42
HV304_RS07250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV304_RS07250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS07250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS07265	COG2207	Transcriptional regulator
HV304_RS07270	COG3279	Response regulator of the LytR AlgR family
HV304_RS07275	COG3275	phosphorelay sensor kinase activity
HV304_RS07280	COG0436	Aminotransferase
HV304_RS07295	COG1560	Kdo2-lipid A biosynthetic process
HV304_RS07300	COG3039	Transposase
HV304_RS07325	COG3122	Protein conserved in bacteria
HV304_RS07330	COG0840	transmembrane signaling receptor activity
HV304_RS07375	COG0629	single-stranded DNA binding
HV304_RS07510	COG3772	lysozyme
HV304_RS07535	COG1783	phage Terminase large subunit
HV304_RS07555	COG0582	viral genome integration into host DNA
HV304_RS07755	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV304_RS07770	COG0582	viral genome integration into host DNA
HV304_RS07780	COG2116	formate transmembrane transporter activity
HV304_RS07790	COG2067	long-chain fatty acid transport protein
HV304_RS07795	COG3691	Protein conserved in bacteria
HV304_RS07810	COG2062	phosphohistidine phosphatase, SixA
HV304_RS07835	COG0730	response to heat
HV304_RS07840	COG3101	peptidyl-lysine hydroxylation
HV304_RS07855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV304_RS07875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV304_RS07885	COG0586	Pfam SNARE associated Golgi protein
HV304_RS07895	COG0285	dihydrofolate synthase activity
HV304_RS07900	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV304_RS07905	COG1286	toxin biosynthetic process
HV304_RS07910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV304_RS07915	COG0163	prenyltransferase activity
HV304_RS07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV304_RS07930	COG4215	(ABC) transporter
HV304_RS07940	COG4598	ABC transporter
HV304_RS07945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV304_RS07950	COG1090	epimerase
HV304_RS07955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV304_RS07960	COG0625	glutathione transferase activity
HV304_RS07965	COG0625	glutathione transferase activity
HV304_RS07970	COG0622	Phosphoesterase
HV304_RS07980	COG1288	antiporter activity
HV304_RS08005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV304_RS08010	COG0471	metal ion transport
HV304_RS08010	COG0490	domain, Protein
HV304_RS08020	COG0436	Aminotransferase
HV304_RS08025	COG0583	DNA-binding transcription factor activity
HV304_RS08045	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV304_RS08070	COG0839	Belongs to the complex I subunit 6 family
HV304_RS08080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV304_RS08085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV304_RS08095	COG0835	chemotaxis
HV304_RS08095	COG0784	Response regulator, receiver
HV304_RS08105	COG2153	protein acetylation
HV304_RS08110	COG4575	ribosome binding
HV304_RS08115	COG1169	isochorismate synthase
HV304_RS08200	COG5464	transposase or invertase
HV304_RS08205	COG0247	lactate metabolic process
HV304_RS08215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV304_RS08220	COG2271	Major facilitator Superfamily
HV304_RS08225	COG0584	glycerophosphoryl diester phosphodiesterase
HV304_RS08230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV304_RS08265	COG2198	Histidine kinase
HV304_RS08265	COG0642	Histidine kinase
HV304_RS08270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV304_RS08275	COG1477	protein flavinylation
HV304_RS08280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV304_RS08280	COG2169	Transcriptional regulator
HV304_RS08285	COG3145	DNA-N1-methyladenine dioxygenase activity
HV304_RS08290	COG4615	Cyclic peptide transporter
HV304_RS08295	COG2239	Acts as a magnesium transporter
HV304_RS08300	COG0659	secondary active sulfate transmembrane transporter activity
HV304_RS08315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV304_RS08315	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV304_RS08320	COG3062	negative regulation of establishment of protein localization
HV304_RS08330	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS08335	COG0348	domain, Protein
HV304_RS08340	COG3043	anaerobic respiration
HV304_RS08345	COG3005	denitrification pathway
HV304_RS08350	COG4133	protoheme IX ABC transporter activity
HV304_RS08360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV304_RS08365	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV304_RS08375	COG1138	Cytochrome C-type biogenesis protein
HV304_RS08380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV304_RS08385	COG3088	subunit of a heme lyase
HV304_RS08385	COG4235	cytochrome complex assembly
HV304_RS08390	COG2197	response regulator
HV304_RS08405	COG3039	Transposase
HV304_RS08455	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HV304_RS08460	COG5532	Uncharacterized conserved protein (DUF2303)
HV304_RS08495	COG4626	Terminase
HV304_RS08495	COG1802	Transcriptional regulator
HV304_RS08500	COG4725	Belongs to the MT-A70-like family
HV304_RS08515	COG1403	HNH endonuclease
HV304_RS08520	COG0484	heat shock protein binding
HV304_RS08535	COG3772	lysozyme
HV304_RS08555	COG4220	transposase activity
HV304_RS08575	COG1030	water channel activity
HV304_RS08625	COG1196	nuclear chromosome segregation
HV304_RS08740	COG1061	Type III restriction enzyme res subunit
HV304_RS08745	COG1187	pseudouridine synthase activity
HV304_RS08750	COG2814	Major facilitator Superfamily
HV304_RS08760	COG4172	Belongs to the ABC transporter superfamily
HV304_RS08765	COG4239	(ABC) transporter, permease
HV304_RS08770	COG4174	ABC transporter (Permease)
HV304_RS08775	COG4166	transmembrane transport
HV304_RS08780	COG2200	EAL domain
HV304_RS08785	COG0791	NLP P60 protein
HV304_RS08790	COG0671	phosphoesterase, PA-phosphatase related
HV304_RS08795	COG0523	cobalamin synthesis protein
HV304_RS08800	COG0246	Mannitol dehydrogenase
HV304_RS08805	COG1312	Catalyzes the dehydration of D-mannonate
HV304_RS08815	COG3039	Transposase
HV304_RS08820	COG3005	denitrification pathway
HV304_RS08830	COG3381	protein complex oligomerization
HV304_RS08855	COG1105	Belongs to the carbohydrate kinase PfkB family
HV304_RS08860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS08860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS08860	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV304_RS08865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV304_RS08875	COG0583	DNA-binding transcription factor activity
HV304_RS08880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS08885	COG2313	pseudouridylate synthase activity
HV304_RS08890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV304_RS08895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS08895	COG1522	sequence-specific DNA binding
HV304_RS08905	COG2855	membrane
HV304_RS08910	COG0583	DNA-binding transcription factor activity
HV304_RS08915	COG0833	amino acid
HV304_RS08920	COG4771	TonB-dependent receptor
HV304_RS08935	COG2311	Membrane
HV304_RS08950	COG1129	ABC transporter
HV304_RS08965	COG0493	'glutamate synthase
HV304_RS08975	COG2949	membrane
HV304_RS08985	COG1346	cytolysis
HV304_RS09000	COG2271	Major facilitator Superfamily
HV304_RS09015	COG0625	glutathione transferase activity
HV304_RS09020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV304_RS09025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV304_RS09040	COG0586	Pfam SNARE associated Golgi protein
HV304_RS09050	COG1686	Belongs to the peptidase S11 family
HV304_RS09055	COG0277	FAD linked oxidase domain protein
HV304_RS09060	COG1472	Belongs to the glycosyl hydrolase 3 family
HV304_RS09065	COG1732	Glycine betaine
HV304_RS09070	COG1174	glycine betaine transport
HV304_RS09075	COG1125	glycine betaine transport
HV304_RS09080	COG1174	glycine betaine transport
HV304_RS09090	COG0789	Transcriptional regulator
HV304_RS09095	COG3275	phosphorelay sensor kinase activity
HV304_RS09105	COG4807	Protein conserved in bacteria
HV304_RS09110	COG4808	Protein conserved in bacteria
HV304_RS09120	COG0489	protein tyrosine kinase activity
HV304_RS09135	COG3039	Transposase
HV304_RS09140	COG3188	usher protein
HV304_RS09150	COG5455	response to cobalt ion
HV304_RS09180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV304_RS09220	COG0351	phosphomethylpyrimidine kinase
HV304_RS09225	COG2188	Transcriptional regulator
HV304_RS09230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS09235	COG1397	ADP-ribosylglycohydrolase
HV304_RS09240	COG2211	Major facilitator Superfamily
HV304_RS09245	COG1830	Aldolase
HV304_RS09255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV304_RS09260	COG4160	amino acid transport
HV304_RS09265	COG4215	(ABC) transporter
HV304_RS09270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV304_RS09275	COG1126	abc transporter atp-binding protein
HV304_RS09290	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV304_RS09295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV304_RS09300	COG0702	epimerase
HV304_RS09305	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV304_RS09310	COG0028	Belongs to the TPP enzyme family
HV304_RS09320	COG4529	Protein conserved in bacteria
HV304_RS09325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV304_RS09335	COG2431	L-lysine efflux transmembrane transporter activity
HV304_RS09345	COG3593	DNA synthesis involved in DNA repair
HV304_RS09350	COG2990	Protein conserved in bacteria
HV304_RS09355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV304_RS09365	COG1278	Cold shock
HV304_RS09375	COG0542	response to heat
HV304_RS09390	COG0745	RESPONSE REGULATOR receiver
HV304_RS09395	COG2205	protein histidine kinase activity
HV304_RS09425	COG0443	Heat shock 70 kDa protein
HV304_RS09430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV304_RS09435	COG3447	MASE1 domain protein
HV304_RS09435	COG5002	protein histidine kinase activity
HV304_RS09435	COG5001	Diguanylate cyclase
HV304_RS09450	COG2982	Protein involved in outer membrane biogenesis
HV304_RS09455	COG1253	flavin adenine dinucleotide binding
HV304_RS09475	COG0463	Glycosyl transferase, family 2
HV304_RS09480	COG1045	serine acetyltransferase
HV304_RS09485	COG0438	transferase activity, transferring glycosyl groups
HV304_RS09495	COG1216	Glycosyl transferase, family 2
HV304_RS09500	COG0110	maltose O-acetyltransferase activity
HV304_RS09505	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV304_RS09510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV304_RS09515	COG1051	belongs to the nudix hydrolase family
HV304_RS09520	COG0297	glycogen (starch) synthase activity
HV304_RS09530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV304_RS09535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV304_RS09540	COG2244	polysaccharide biosynthetic process
HV304_RS09545	COG2327	Polysaccharide pyruvyl transferase
HV304_RS09560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV304_RS09570	COG1088	dTDP-glucose 4,6-dehydratase activity
HV304_RS09595	COG0438	transferase activity, transferring glycosyl groups
HV304_RS09595	COG4641	Protein conserved in bacteria
HV304_RS09605	COG1216	Glycosyl transferase, family 2
HV304_RS09620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV304_RS09635	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV304_RS09655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV304_RS09685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV304_RS09690	COG0583	DNA-binding transcription factor activity
HV304_RS09700	COG0531	amino acid
HV304_RS09705	COG2925	Exonuclease
HV304_RS09715	COG3039	Transposase
HV304_RS09745	COG1289	transmembrane transporter activity
HV304_RS09780	COG4656	Part of a membrane complex involved in electron transport
HV304_RS09790	COG1012	belongs to the aldehyde dehydrogenase family
HV304_RS09970	COG1376	ErfK ybiS ycfS ynhG family protein
HV304_RS09975	COG3842	ATPase activity
HV304_RS09980	COG1178	ABC-type Fe3 transport system permease component
HV304_RS09985	COG1840	ABC-type Fe3 transport system, periplasmic component
HV304_RS10005	COG2076	Multidrug Resistance protein
HV304_RS10010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV304_RS10015	COG1418	mRNA catabolic process
HV304_RS10020	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV304_RS10025	COG3727	T/G mismatch-specific endonuclease activity
HV304_RS10030	COG0697	spore germination
HV304_RS10035	COG2354	Protein conserved in bacteria
HV304_RS10040	COG5475	Uncharacterized small protein (DUF2158)
HV304_RS10100	COG2882	bacterial-type flagellum organization
HV304_RS10105	COG1157	protein secretion by the type III secretion system
HV304_RS10130	COG0425	Belongs to the sulfur carrier protein TusA family
HV304_RS10145	COG0366	Alpha amylase catalytic
HV304_RS10170	COG3039	Transposase
HV304_RS10175	COG3039	Transposase
HV304_RS10185	COG1335	isochorismatase
HV304_RS10190	COG0252	asparaginase activity
HV304_RS10195	COG0616	signal peptide processing
HV304_RS10200	COG0778	Nitroreductase
HV304_RS10210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV304_RS10225	COG0494	nUDIX hydrolase
HV304_RS10230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV304_RS10235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV304_RS10240	COG2897	thiosulfate sulfurtransferase activity
HV304_RS10245	COG4136	ATPase activity
HV304_RS10250	COG4135	transport system, permease component
HV304_RS10255	COG4134	Bacterial extracellular solute-binding protein
HV304_RS10260	COG0398	Pfam SNARE associated Golgi protein
HV304_RS10265	COG0398	Pfam SNARE associated Golgi protein
HV304_RS10270	COG0708	Exodeoxyribonuclease III
HV304_RS10300	COG3678	ATP-independent chaperone mediated protein folding
HV304_RS10310	COG0322	excinuclease ABC activity
HV304_RS10320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV304_RS10325	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV304_RS10330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV304_RS10335	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV304_RS10340	COG2169	Transcriptional regulator
HV304_RS10340	COG1917	Cupin 2, conserved barrel domain protein
HV304_RS10345	COG1486	melibiose metabolic process
HV304_RS10355	COG0753	catalase activity
HV304_RS10370	COG1988	membrane-bound metal-dependent
HV304_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS10380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV304_RS10390	COG3001	Fructosamine kinase
HV304_RS10395	COG1105	Belongs to the carbohydrate kinase PfkB family
HV304_RS10400	COG3137	Salt-induced outer membrane protein
HV304_RS10420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV304_RS10455	COG0386	Belongs to the glutathione peroxidase family
HV304_RS10465	COG0791	NLP P60 protein
HV304_RS10485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS10490	COG4558	Periplasmic binding protein
HV304_RS10495	COG3720	iron ion transport
HV304_RS10500	COG4771	TonB-dependent receptor
HV304_RS10505	COG4256	Hemin uptake protein
HV304_RS10510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV304_RS10520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV304_RS10520	COG0574	Belongs to the PEP-utilizing enzyme family
HV304_RS10525	COG0318	PFAM AMP-dependent synthetase and ligase
HV304_RS10530	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV304_RS10535	COG0644	oxidoreductase
HV304_RS10540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV304_RS10545	COG2086	electron transfer activity
HV304_RS10550	COG1917	Cupin 2, conserved barrel domain protein
HV304_RS10550	COG2207	Transcriptional regulator
HV304_RS10555	COG1960	acyl-CoA dehydrogenase activity
HV304_RS10560	COG4670	ketone body catabolic process
HV304_RS10575	COG3039	Transposase
HV304_RS10580	COG2271	Major facilitator Superfamily
HV304_RS10585	COG0738	Major facilitator superfamily
HV304_RS10600	COG0628	permease
HV304_RS10605	COG0277	FAD linked oxidase domain protein
HV304_RS10605	COG0247	lactate metabolic process
HV304_RS10610	COG2050	protein possibly involved in aromatic compounds catabolism
HV304_RS10625	COG0583	DNA-binding transcription factor activity
HV304_RS10630	COG0316	Belongs to the HesB IscA family
HV304_RS10635	COG0719	Fe-S assembly protein
HV304_RS10640	COG0396	ATPase activity
HV304_RS10645	COG0719	Fe-S assembly protein
HV304_RS10660	COG1376	ErfK ybiS ycfS ynhG family protein
HV304_RS10675	COG0531	amino acid
HV304_RS10680	COG2267	carboxylic ester hydrolase activity
HV304_RS10690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS10700	COG2011	ABC-type metal ion transport system permease component
HV304_RS10705	COG1464	Belongs to the NlpA lipoprotein family
HV304_RS10750	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS10755	COG2414	aldehyde ferredoxin oxidoreductase
HV304_RS10765	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS10770	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV304_RS10780	COG0765	amino acid transport
HV304_RS10795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV304_RS10805	COG1113	amino acid transport
HV304_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
HV304_RS10830	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV304_RS10845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV304_RS10890	COG4977	sequence-specific DNA binding
HV304_RS10905	COG3188	usher protein
HV304_RS10910	COG3121	Chaperone
HV304_RS10925	COG2378	regulation of single-species biofilm formation
HV304_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS10945	COG0628	permease
HV304_RS10950	COG0386	Belongs to the glutathione peroxidase family
HV304_RS10955	COG3300	MHYT domain
HV304_RS10955	COG5001	Diguanylate cyclase
HV304_RS10975	COG0251	oxidation-reduction process
HV304_RS11000	COG0307	riboflavin synthase, alpha
HV304_RS11005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV304_RS11010	COG2814	Major facilitator Superfamily
HV304_RS11015	COG0583	DNA-binding transcription factor activity
HV304_RS11030	COG2814	Major facilitator Superfamily
HV304_RS11035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV304_RS11040	COG0791	NLP P60 protein
HV304_RS11045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV304_RS11055	COG0346	lactoylglutathione lyase activity
HV304_RS11060	COG1902	pentaerythritol trinitrate reductase activity
HV304_RS11065	COG1309	transcriptional regulator
HV304_RS11070	COG3313	Fe-S protein
HV304_RS11075	COG4989	oxidoreductase activity
HV304_RS11080	COG2032	superoxide dismutase activity
HV304_RS11090	COG1566	PFAM secretion protein HlyD family protein
HV304_RS11115	COG3895	Periplasmic Protein
HV304_RS11130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV304_RS11135	COG0625	glutathione transferase activity
HV304_RS11145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV304_RS11195	COG0673	inositol 2-dehydrogenase activity
HV304_RS11205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV304_RS11210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS11210	COG1263	PTS System
HV304_RS11215	COG1609	Transcriptional regulator
HV304_RS11220	COG5339	Protein conserved in bacteria
HV304_RS11230	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS11230	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS11245	COG2205	protein histidine kinase activity
HV304_RS11260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV304_RS11270	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV304_RS11280	COG0745	RESPONSE REGULATOR receiver
HV304_RS11285	COG3136	membrane protein required for alginate biosynthesis
HV304_RS11295	COG0531	amino acid
HV304_RS11305	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV304_RS11310	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV304_RS11315	COG0628	permease
HV304_RS11330	COG3591	Belongs to the peptidase S1B family
HV304_RS11340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV304_RS11355	COG0745	RESPONSE REGULATOR receiver
HV304_RS11360	COG2205	protein histidine kinase activity
HV304_RS11370	COG2814	Major facilitator Superfamily
HV304_RS11375	COG0583	DNA-binding transcription factor activity
HV304_RS11380	COG1940	carbohydrate kinase activity
HV304_RS11385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV304_RS11395	COG3381	protein complex oligomerization
HV304_RS11400	COG3302	dmso reductase anchor subunit
HV304_RS11405	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS11425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV304_RS11440	COG4948	Mandelate Racemase Muconate Lactonizing
HV304_RS11450	COG0246	Mannitol dehydrogenase
HV304_RS11460	COG1802	Transcriptional regulator
HV304_RS11465	COG4221	oxidoreductase activity
HV304_RS11480	COG3706	GGDEF domain
HV304_RS11505	COG1129	ABC transporter
HV304_RS11510	COG0410	ABC transporter
HV304_RS11515	COG2814	Major facilitator Superfamily
HV304_RS11535	COG1846	Transcriptional regulator
HV304_RS11550	COG0583	DNA-binding transcription factor activity
HV304_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
HV304_RS11585	COG3781	membrane
HV304_RS11600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV304_RS11610	COG2801	Transposase and inactivated derivatives
HV304_RS11625	COG3121	Chaperone
HV304_RS11655	COG4628	conserved protein (DUF2132)
HV304_RS11695	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV304_RS11700	COG0747	negative chemotaxis
HV304_RS11705	COG0601	transmembrane transport
HV304_RS11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV304_RS11715	COG0444	Belongs to the ABC transporter superfamily
HV304_RS11720	COG4608	Belongs to the ABC transporter superfamily
HV304_RS11730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV304_RS11735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV304_RS11745	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV304_RS11750	COG2610	gluconate transmembrane transporter activity
HV304_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS11760	COG1764	response to oxidative stress
HV304_RS11775	COG0488	(ABC) transporter
HV304_RS11780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HV304_RS11785	COG2864	formate dehydrogenase
HV304_RS11790	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS11800	COG0697	spore germination
HV304_RS11825	COG2223	nitrite transmembrane transporter activity
HV304_RS11830	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV304_RS11835	COG1140	nitrate reductase beta subunit
HV304_RS11840	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV304_RS11845	COG2181	nitrate reductase activity
HV304_RS11850	COG0384	phenazine biosynthesis protein PhzF
HV304_RS11865	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV304_RS11870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV304_RS11895	COG0625	glutathione transferase activity
HV304_RS11900	COG0583	DNA-binding transcription factor activity
HV304_RS11905	COG0604	alcohol dehydrogenase
HV304_RS11905	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS11905	COG3321	synthase
HV304_RS11910	COG1126	abc transporter atp-binding protein
HV304_RS11930	COG1473	amidohydrolase
HV304_RS11935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV304_RS11940	COG0840	transmembrane signaling receptor activity
HV304_RS11960	COG2130	NADP-dependent
HV304_RS11970	COG1247	-acetyltransferase
HV304_RS11975	COG3238	Protein conserved in bacteria
HV304_RS11985	COG0747	negative chemotaxis
HV304_RS12015	COG2207	Transcriptional regulator
HV304_RS12020	COG2814	Major facilitator Superfamily
HV304_RS12030	COG1177	transmembrane transport
HV304_RS12035	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV304_RS12040	COG3842	ATPase activity
HV304_RS12045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV304_RS12050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV304_RS12055	COG1598	PFAM Uncharacterised protein family UPF0150
HV304_RS12060	COG1724	mRNA binding
HV304_RS12065	COG1271	oxidase subunit
HV304_RS12070	COG1294	oxidase, subunit
HV304_RS12085	COG0826	peptidase U32
HV304_RS12090	COG1396	sequence-specific DNA binding
HV304_RS12095	COG3135	benzoate transporter
HV304_RS12115	COG0500	methyltransferase
HV304_RS12120	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV304_RS12125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV304_RS12130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV304_RS12140	COG2841	Protein conserved in bacteria
HV304_RS12150	COG5383	Protein conserved in bacteria
HV304_RS12155	COG1227	inorganic diphosphatase activity
HV304_RS12160	COG0583	DNA-binding transcription factor activity
HV304_RS12170	COG3121	Chaperone
HV304_RS12175	COG3188	usher protein
HV304_RS12195	COG0840	transmembrane signaling receptor activity
HV304_RS12235	COG3383	formate dehydrogenase (NAD+) activity
HV304_RS12235	COG0243	molybdopterin cofactor binding
HV304_RS12240	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS12245	COG2864	formate dehydrogenase
HV304_RS12250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV304_RS12260	COG3038	cytochrome b561
HV304_RS12265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV304_RS12270	COG0657	acetylesterase activity
HV304_RS12270	COG2755	lipolytic protein G-D-S-L family
HV304_RS12275	COG1012	belongs to the aldehyde dehydrogenase family
HV304_RS12280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV304_RS12285	COG1643	Atp-dependent helicase
HV304_RS12300	COG3784	Protein of unknown function (DUF1318)
HV304_RS12310	COG2911	Protein conserved in bacteria
HV304_RS12315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV304_RS12320	COG3187	Heat shock protein
HV304_RS12325	COG3042	response to heat
HV304_RS12330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV304_RS12330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV304_RS12330	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV304_RS12330	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV304_RS12335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV304_RS12345	COG0589	response to stress
HV304_RS12355	COG0513	Belongs to the DEAD box helicase family
HV304_RS12365	COG0840	transmembrane signaling receptor activity
HV304_RS12370	COG3039	Transposase
HV304_RS12380	COG3706	GGDEF domain
HV304_RS12400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV304_RS12415	COG3182	Iron-regulated membrane protein
HV304_RS12420	COG0668	transmembrane transport
HV304_RS12430	COG0346	lactoylglutathione lyase activity
HV304_RS12435	COG1349	DNA-binding transcription factor activity
HV304_RS12455	COG4166	transmembrane transport
HV304_RS12460	COG2866	Carboxypeptidase
HV304_RS12465	COG4948	Mandelate Racemase Muconate Lactonizing
HV304_RS12470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV304_RS12485	COG3106	COG3106 Predicted ATPase
HV304_RS12495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV304_RS12500	COG1609	Transcriptional regulator
HV304_RS12510	COG3842	ATPase activity
HV304_RS12515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV304_RS12520	COG1554	hydrolase, family 65, central catalytic
HV304_RS12525	COG0673	inositol 2-dehydrogenase activity
HV304_RS12530	COG1082	Xylose isomerase domain protein TIM barrel
HV304_RS12535	COG1063	alcohol dehydrogenase
HV304_RS12540	COG0395	ABC-type sugar transport system, permease component
HV304_RS12545	COG1175	transmembrane transport
HV304_RS12555	COG0366	Alpha amylase catalytic
HV304_RS12565	COG1983	PspC domain protein
HV304_RS12575	COG1842	Phage shock protein A
HV304_RS12580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV304_RS12605	COG4171	peptide transport system, permease
HV304_RS12625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV304_RS12630	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV304_RS12630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV304_RS12640	COG5001	Diguanylate cyclase
HV304_RS12650	COG1349	DNA-binding transcription factor activity
HV304_RS12660	COG0023	Translation Initiation Factor
HV304_RS12670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV304_RS12675	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV304_RS12680	COG0671	phosphoesterase, PA-phosphatase related
HV304_RS12690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV304_RS12705	COG0583	DNA-binding transcription factor activity
HV304_RS12720	COG0616	signal peptide processing
HV304_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS12735	COG1187	pseudouridine synthase activity
HV304_RS12740	COG0009	L-threonylcarbamoyladenylate synthase
HV304_RS12775	COG3706	GGDEF domain
HV304_RS12790	COG0217	transcriptional regulatory protein
HV304_RS12795	COG3047	cAMP biosynthetic process
HV304_RS12820	COG2350	Protein conserved in bacteria
HV304_RS12840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV304_RS12850	COG0444	Belongs to the ABC transporter superfamily
HV304_RS12870	COG2095	MarC family integral membrane protein
HV304_RS12875	COG1012	belongs to the aldehyde dehydrogenase family
HV304_RS12875	COG1454	alcohol dehydrogenase
HV304_RS12880	COG1435	thymidine kinase activity
HV304_RS12890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV304_RS12895	COG0745	RESPONSE REGULATOR receiver
HV304_RS12900	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV304_RS12910	COG0788	formyltetrahydrofolate deformylase activity
HV304_RS12935	COG2181	nitrate reductase activity
HV304_RS12940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV304_RS12945	COG1140	nitrate reductase beta subunit
HV304_RS12950	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV304_RS12955	COG2223	nitrite transmembrane transporter activity
HV304_RS12960	COG3850	Histidine kinase
HV304_RS12965	COG2197	response regulator
HV304_RS12970	COG4932	domain protein
HV304_RS12975	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV304_RS12985	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV304_RS12990	COG0387	Pfam Sodium calcium exchanger
HV304_RS13005	COG3094	Invasion gene expression up-regulator, SirB
HV304_RS13010	COG2890	protein-(glutamine-N5) methyltransferase activity
HV304_RS13040	COG0659	secondary active sulfate transmembrane transporter activity
HV304_RS13045	COG0076	glutamate decarboxylase activity
HV304_RS13050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV304_RS13055	COG0527	aspartate kinase activity
HV304_RS13070	COG0012	GTP binding
HV304_RS13100	COG3039	Transposase
HV304_RS13115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV304_RS13120	COG2376	Dihydroxyacetone kinase
HV304_RS13125	COG1461	Dihydroxyacetone kinase
HV304_RS13150	COG1120	ATPase activity
HV304_RS13155	COG0500	methyltransferase
HV304_RS13160	COG0157	Belongs to the NadC ModD family
HV304_RS13185	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV304_RS13195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV304_RS13205	COG2719	SpoVR family
HV304_RS13235	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV304_RS13250	COG2894	cell division
HV304_RS13260	COG0583	DNA-binding transcription factor activity
HV304_RS13265	COG0473	3-isopropylmalate dehydrogenase activity
HV304_RS13270	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV304_RS13275	COG0318	PFAM AMP-dependent synthetase and ligase
HV304_RS13280	COG3065	identical protein binding
HV304_RS13285	COG1214	PFAM Peptidase M22, glycoprotease
HV304_RS13290	COG1199	ATP-dependent helicase activity
HV304_RS13295	COG0251	oxidation-reduction process
HV304_RS13315	COG1760	l-serine dehydratase
HV304_RS13320	COG2200	EAL domain
HV304_RS13325	COG1253	flavin adenine dinucleotide binding
HV304_RS13330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS13330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS13335	COG3715	PTS system
HV304_RS13340	COG3716	PTS system mannose fructose sorbose family IID component
HV304_RS13355	COG2226	methyltransferase
HV304_RS13360	COG0768	penicillin binding
HV304_RS13390	COG1414	Transcriptional regulator
HV304_RS13395	COG2814	Major facilitator Superfamily
HV304_RS13410	COG3039	Transposase
HV304_RS13535	COG1956	GAF domain-containing protein
HV304_RS13540	COG2995	paraquat-inducible protein a
HV304_RS13545	COG3008	intermembrane lipid transfer
HV304_RS13565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV304_RS13575	COG1276	copper resistance
HV304_RS13580	COG2372	response to copper ion
HV304_RS13605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV304_RS13610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV304_RS13615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV304_RS13620	COG1770	oligopeptidase
HV304_RS13625	COG2979	Protein of unknown function (DUF533)
HV304_RS13635	COG3141	response to X-ray
HV304_RS13645	COG0800	Aldolase
HV304_RS13650	COG0129	dihydroxy-acid dehydratase activity
HV304_RS13655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV304_RS13660	COG1737	Transcriptional regulator
HV304_RS13670	COG1560	Kdo2-lipid A biosynthetic process
HV304_RS13675	COG0739	heme binding
HV304_RS13680	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV304_RS13690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV304_RS13715	COG0494	nUDIX hydrolase
HV304_RS13725	COG1335	isochorismatase
HV304_RS13730	COG1801	Protein of unknown function DUF72
HV304_RS13735	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV304_RS13755	COG3102	Protein conserved in bacteria
HV304_RS13770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV304_RS13795	COG0745	RESPONSE REGULATOR receiver
HV304_RS13810	COG0840	transmembrane signaling receptor activity
HV304_RS13820	COG1301	dicarboxylic acid transport
HV304_RS13830	COG0835	chemotaxis
HV304_RS13860	COG0589	response to stress
HV304_RS13875	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV304_RS13880	COG1129	ABC transporter
HV304_RS13885	COG1879	ABC-type sugar transport system periplasmic component
HV304_RS13895	COG1528	Iron-storage protein
HV304_RS13905	COG0477	Major facilitator Superfamily
HV304_RS13920	COG1528	Iron-storage protein
HV304_RS13930	COG0814	amino acid
HV304_RS13935	COG3012	SEC-C Motif Domain Protein
HV304_RS13935	COG3318	Belongs to the UPF0149 family
HV304_RS13940	COG2608	mercury ion transmembrane transporter activity
HV304_RS13950	COG1305	Transglutaminase-like
HV304_RS13975	COG2801	Transposase and inactivated derivatives
HV304_RS14010	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV304_RS14020	COG3012	SEC-C Motif Domain Protein
HV304_RS14020	COG3318	Belongs to the UPF0149 family
HV304_RS14135	COG2197	response regulator
HV304_RS14145	COG2197	response regulator
HV304_RS14185	COG3039	Transposase
HV304_RS14190	COG3039	Transposase
HV304_RS14200	COG1349	DNA-binding transcription factor activity
HV304_RS14205	COG0667	Aldo Keto reductase
HV304_RS14210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS14215	COG0191	fructose-bisphosphate aldolase activity
HV304_RS14220	COG1063	alcohol dehydrogenase
HV304_RS14225	COG2271	Major facilitator Superfamily
HV304_RS14230	COG1063	alcohol dehydrogenase
HV304_RS14245	COG3139	Protein of unknown function (DUF1315)
HV304_RS14265	COG0656	L-ascorbic acid biosynthetic process
HV304_RS14270	COG3713	MltA-interacting MipA family protein
HV304_RS14275	COG2766	serine protein kinase
HV304_RS14285	COG2226	methyltransferase
HV304_RS14290	COG2199	diguanylate cyclase activity
HV304_RS14295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV304_RS14305	COG2207	Transcriptional regulator
HV304_RS14310	COG2807	transmembrane transport
HV304_RS14315	COG0504	CTP synthase activity
HV304_RS14320	COG3189	MarR family transcriptional regulator
HV304_RS14325	COG3042	response to heat
HV304_RS14330	COG2203	Gaf domain
HV304_RS14330	COG2199	diguanylate cyclase activity
HV304_RS14345	COG2261	transglycosylase associated protein
HV304_RS14350	COG3383	formate dehydrogenase (NAD+) activity
HV304_RS14365	COG3615	Tellurite resistance protein tehB
HV304_RS14375	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV304_RS14380	COG1124	(ABC) transporter
HV304_RS14390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV304_RS14395	COG0601	transmembrane transport
HV304_RS14400	COG0747	negative chemotaxis
HV304_RS14405	COG4771	TonB-dependent receptor
HV304_RS14420	COG2200	EAL domain
HV304_RS14450	COG0538	isocitrate dehydrogenase activity
HV304_RS14470	COG0431	NADPH-dependent FMN reductase
HV304_RS14500	COG0538	isocitrate dehydrogenase activity
HV304_RS14530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV304_RS14535	COG2135	peptidase activity
HV304_RS14545	COG3272	Protein of unknown function (DUF1722)
HV304_RS14565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV304_RS14580	COG0300	oxidoreductase activity
HV304_RS14590	COG0789	Transcriptional regulator
HV304_RS14675	COG0616	signal peptide processing
HV304_RS14690	COG1802	Transcriptional regulator
HV304_RS14690	COG4626	Terminase
HV304_RS14705	COG3038	cytochrome b561
HV304_RS14750	COG3772	lysozyme
HV304_RS14775	COG1403	HNH endonuclease
HV304_RS14780	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HV304_RS14815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV304_RS14870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV304_RS14880	COG0582	viral genome integration into host DNA
HV304_RS14895	COG2850	peptidyl-arginine hydroxylation
HV304_RS14915	COG1177	transmembrane transport
HV304_RS14925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV304_RS14935	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV304_RS14940	COG1136	(ABC) transporter
HV304_RS14945	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV304_RS14950	COG4763	Acyl-transferase
HV304_RS14955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV304_RS14960	COG1388	LysM domain
HV304_RS14960	COG1376	ErfK ybiS ycfS ynhG family protein
HV304_RS14970	COG1309	transcriptional regulator
HV304_RS14980	COG3134	Outer membrane lipoprotein
HV304_RS14985	COG1252	NADH dehydrogenase
HV304_RS15010	COG5633	Lipoprotein
HV304_RS15015	COG0537	adenosine 5'-monophosphoramidase activity
HV304_RS15025	COG3039	Transposase
HV304_RS15040	COG0309	Hydrogenase expression formation protein (HypE)
HV304_RS15045	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV304_RS15050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV304_RS15055	COG2223	nitrite transmembrane transporter activity
HV304_RS15065	COG0534	Mate efflux family protein
HV304_RS15075	COG0583	DNA-binding transcription factor activity
HV304_RS15100	COG3039	Transposase
HV304_RS15105	COG1595	DNA-templated transcription, initiation
HV304_RS15110	COG3712	iron ion homeostasis
HV304_RS15120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV304_RS15125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS15130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS15135	COG1120	ATPase activity
HV304_RS15145	COG0406	alpha-ribazole phosphatase activity
HV304_RS15160	COG0477	Major facilitator Superfamily
HV304_RS15165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV304_RS15180	COG0084	hydrolase, TatD family'
HV304_RS15185	COG0470	DNA polymerase III
HV304_RS15195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV304_RS15200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV304_RS15205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV304_RS15240	COG1399	metal-binding, possibly nucleic acid-binding protein
HV304_RS15250	COG0564	pseudouridine synthase activity
HV304_RS15255	COG1530	ribonuclease E activity
HV304_RS15260	COG0583	DNA-binding transcription factor activity
HV304_RS15265	COG2814	Major facilitator Superfamily
HV304_RS15295	COG4786	Flagellar basal body rod
HV304_RS15300	COG4787	bacterial-type flagellum-dependent cell motility
HV304_RS15315	COG1558	bacterial-type flagellum-dependent cell motility
HV304_RS15355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV304_RS15395	COG3038	cytochrome b561
HV304_RS15410	COG1560	Kdo2-lipid A biosynthetic process
HV304_RS15420	COG2199	diguanylate cyclase activity
HV304_RS15430	COG5645	(Lipo)protein
HV304_RS15450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV304_RS15505	COG3381	protein complex oligomerization
HV304_RS15530	COG2962	Rard protein
HV304_RS15535	COG2990	Protein conserved in bacteria
HV304_RS15540	COG1702	phosphate starvation-inducible protein PhoH
HV304_RS15555	COG2822	iron ion transport
HV304_RS15565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV304_RS15570	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV304_RS15570	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV304_RS15570	COG0506	proline dehydrogenase activity
HV304_RS15575	COG3755	Protein conserved in bacteria
HV304_RS15580	COG1309	transcriptional regulator
HV304_RS15590	COG3729	General stress protein
HV304_RS15610	COG0640	Transcriptional regulator
HV304_RS15630	COG1136	(ABC) transporter
HV304_RS15630	COG0577	efflux transmembrane transporter activity
HV304_RS15640	COG1136	(ABC) transporter
HV304_RS15640	COG0577	efflux transmembrane transporter activity
HV304_RS15655	COG0672	)-iron permease
HV304_RS15660	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV304_RS15665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV304_RS15670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV304_RS15670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV304_RS15720	COG0813	purine-nucleoside phosphorylase activity
HV304_RS15735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS15740	COG1120	ATPase activity
HV304_RS15750	COG0723	plastoquinol--plastocyanin reductase activity
HV304_RS15755	COG2857	Cytochrome c1
HV304_RS15755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV304_RS15775	COG0670	Belongs to the BI1 family
HV304_RS15800	COG1832	CoA-binding protein
HV304_RS15815	COG0210	DNA helicase
HV304_RS15820	COG3304	Inner membrane component domain
HV304_RS15825	COG1289	transmembrane transporter activity
HV304_RS15830	COG3070	regulator of competence-specific genes
HV304_RS15850	COG1067	ATP-dependent peptidase activity
HV304_RS15860	COG3130	regulation of translation
HV304_RS15865	COG3009	Protein conserved in bacteria
HV304_RS15870	COG3008	intermembrane lipid transfer
HV304_RS15870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV304_RS15875	COG2995	paraquat-inducible protein a
HV304_RS15880	COG0488	(ABC) transporter
HV304_RS15890	COG0633	Ferredoxin
HV304_RS15890	COG3217	Mosc domain protein beta barrel domain protein
HV304_RS15905	COG0431	NADPH-dependent FMN reductase
HV304_RS15910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV304_RS15920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV304_RS15925	COG1116	anion transmembrane transporter activity
HV304_RS15930	COG0308	aminopeptidase N
HV304_RS15950	COG1448	Aminotransferase
HV304_RS15955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV304_RS15960	COG3108	Peptidase M15
HV304_RS15965	COG2989	Protein conserved in bacteria
HV304_RS15975	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV304_RS15985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV304_RS15990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV304_RS15995	COG3173	Aminoglycoside phosphotransferase
HV304_RS16010	COG3214	Protein conserved in bacteria
HV304_RS16025	COG2333	competence protein COMEC
HV304_RS16025	COG0658	competence protein
HV304_RS16030	COG0776	regulation of translation
HV304_RS16035	COG0539	negative regulation of cytoplasmic translation
HV304_RS16045	COG0501	Belongs to the peptidase M48B family
HV304_RS16060	COG2323	membrane
HV304_RS16065	COG1944	ATP diphosphatase activity
HV304_RS16070	COG2116	formate transmembrane transporter activity
HV304_RS16075	COG1882	Formate acetyltransferase
HV304_RS16080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV304_RS16085	COG0531	amino acid
HV304_RS16095	COG1335	isochorismatase
HV304_RS16100	COG3302	dmso reductase anchor subunit
HV304_RS16105	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS16110	COG0243	molybdopterin cofactor binding
HV304_RS16120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV304_RS16130	COG1178	ABC-type Fe3 transport system permease component
HV304_RS16130	COG1674	ftsk spoiiie
HV304_RS16140	COG0492	ferredoxin-NADP+ reductase activity
HV304_RS16145	COG4988	ABC transporter
HV304_RS16150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV304_RS16165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV304_RS16170	COG0583	DNA-binding transcription factor activity
HV304_RS16180	COG1335	isochorismatase
HV304_RS16205	COG1177	transmembrane transport
HV304_RS16210	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV304_RS16215	COG3842	ATPase activity
HV304_RS16220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV304_RS16280	COG0583	DNA-binding transcription factor activity
HV304_RS16285	COG3226	Transcriptional regulator
HV304_RS16290	COG0738	Major facilitator superfamily
HV304_RS16295	COG0561	phosphatase activity
HV304_RS16305	COG2814	Major facilitator Superfamily
HV304_RS16310	COG0671	phosphoesterase, PA-phosphatase related
HV304_RS16315	COG1349	DNA-binding transcription factor activity
HV304_RS16320	COG1686	Belongs to the peptidase S11 family
HV304_RS16325	COG0625	glutathione transferase activity
HV304_RS16330	COG2133	pyrroloquinoline quinone binding
HV304_RS16365	COG1446	asparaginase
HV304_RS16375	COG0303	'Molybdopterin
HV304_RS16380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV304_RS16385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV304_RS16390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV304_RS16395	COG1882	Formate acetyltransferase
HV304_RS16400	COG0561	phosphatase activity
HV304_RS16410	COG0488	(ABC) transporter
HV304_RS16415	COG1376	ErfK ybiS ycfS ynhG family protein
HV304_RS16420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV304_RS16435	COG2194	sulfuric ester hydrolase activity
HV304_RS16440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV304_RS16455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV304_RS16460	COG0765	amino acid transport
HV304_RS16465	COG1126	abc transporter atp-binding protein
HV304_RS16470	COG0668	transmembrane transport
HV304_RS16485	COG4774	siderophore transport
HV304_RS16495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV304_RS16505	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV304_RS16510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV304_RS16520	COG0471	metal ion transport
HV304_RS16530	COG2188	Transcriptional regulator
HV304_RS16535	COG0513	Belongs to the DEAD box helicase family
HV304_RS16540	COG1309	transcriptional regulator
HV304_RS16550	COG1131	(ABC) transporter
HV304_RS16555	COG0842	Transport permease protein
HV304_RS16560	COG0842	Transport permease protein
HV304_RS16570	COG3568	Endonuclease Exonuclease Phosphatase
HV304_RS16575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV304_RS16580	COG0392	lysyltransferase activity
HV304_RS16585	COG0670	Belongs to the BI1 family
HV304_RS16590	COG0314	molybdopterin synthase activity
HV304_RS16595	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV304_RS16605	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV304_RS16635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV304_RS16655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV304_RS16660	COG1881	PFAM PEBP family protein
HV304_RS16690	COG4677	pectinesterase activity
HV304_RS16700	COG3039	Transposase
HV304_RS16715	COG0561	phosphatase activity
HV304_RS16725	COG4149	molybdate abc transporter
HV304_RS16730	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV304_RS16740	COG2005	Transcriptional regulator
HV304_RS16740	COG3585	molybdate ion transport
HV304_RS16745	COG1119	ATPase activity
HV304_RS16750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV304_RS16755	COG1085	galactose-1-phosphate uridylyltransferase
HV304_RS16765	COG2017	converts alpha-aldose to the beta-anomer
HV304_RS16775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV304_RS16785	COG1230	cation diffusion facilitator family transporter
HV304_RS16790	COG3201	nicotinamide mononucleotide transporter
HV304_RS16830	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV304_RS16835	COG2885	chlorophyll binding
HV304_RS16845	COG3064	Membrane
HV304_RS16850	COG0848	biopolymer transport protein
HV304_RS16855	COG0811	peptide transport
HV304_RS16860	COG0824	Thioesterase
HV304_RS16865	COG3790	cyd operon protein YbgE
HV304_RS16870	COG4890	Cyd operon protein YbgT
HV304_RS16875	COG1294	oxidase, subunit
HV304_RS16880	COG1271	oxidase subunit
HV304_RS16885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV304_RS16895	COG4865	methylaspartate mutase activity
HV304_RS16900	COG3799	methylaspartate ammonia-lyase activity
HV304_RS16915	COG1301	dicarboxylic acid transport
HV304_RS16925	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS16925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS16935	COG0583	DNA-binding transcription factor activity
HV304_RS16940	COG1648	precorrin-2 dehydrogenase activity
HV304_RS16940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV304_RS16950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV304_RS16960	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV304_RS16965	COG0567	Dehydrogenase, E1 component
HV304_RS16970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV304_RS16975	COG1053	succinate dehydrogenase
HV304_RS16980	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV304_RS16985	COG2009	succinate dehydrogenase
HV304_RS16995	COG3157	Type VI secretion system effector, Hcp
HV304_RS17010	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HV304_RS17015	COG3180	Ammonia monooxygenase
HV304_RS17045	COG1984	allophanate hydrolase subunit 2
HV304_RS17050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV304_RS17065	COG5464	transposase or invertase
HV304_RS17075	COG3272	Protein of unknown function (DUF1722)
HV304_RS17105	COG2205	protein histidine kinase activity
HV304_RS17110	COG0745	RESPONSE REGULATOR receiver
HV304_RS17115	COG0033	Phosphoglucomutase
HV304_RS17120	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV304_RS17125	COG0596	Alpha beta hydrolase
HV304_RS17135	COG0716	FMN binding
HV304_RS17145	COG0735	belongs to the Fur family
HV304_RS17150	COG0583	DNA-binding transcription factor activity
HV304_RS17155	COG1053	succinate dehydrogenase
HV304_RS17185	COG2190	(PTS) system
HV304_RS17185	COG1263	PTS System
HV304_RS17185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS17195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV304_RS17200	COG1846	Transcriptional regulator
HV304_RS17200	COG1940	carbohydrate kinase activity
HV304_RS17205	COG0647	UMP catabolic process
HV304_RS17210	COG0367	asparagine synthase
HV304_RS17255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV304_RS17265	COG1702	phosphate starvation-inducible protein PhoH
HV304_RS17275	COG4535	Mg2 and Co2 transporter CorC
HV304_RS17290	COG0765	amino acid transport
HV304_RS17295	COG0765	amino acid transport
HV304_RS17300	COG1126	abc transporter atp-binding protein
HV304_RS17310	COG2888	peptidyl-tyrosine sulfation
HV304_RS17325	COG1466	dna polymerase III delta subunit
HV304_RS17335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV304_RS17345	COG0799	negative regulation of ribosome biogenesis
HV304_RS17355	COG0768	penicillin binding
HV304_RS17360	COG0772	Belongs to the SEDS family
HV304_RS17365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV304_RS17370	COG1686	Belongs to the peptidase S11 family
HV304_RS17395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV304_RS17415	COG3069	C4-dicarboxylate transmembrane transporter activity
HV304_RS17420	COG4565	transcriptional regulatory protein
HV304_RS17425	COG3290	protein histidine kinase activity
HV304_RS17430	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV304_RS17440	COG2301	Belongs to the HpcH HpaI aldolase family
HV304_RS17445	COG3051	citrate lyase alpha subunit
HV304_RS17460	COG0471	metal ion transport
HV304_RS17465	COG3719	Belongs to the RNase T2 family
HV304_RS17480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV304_RS17500	COG0243	molybdopterin cofactor binding
HV304_RS17510	COG3634	alkyl hydroperoxide reductase activity
HV304_RS17520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV304_RS17525	COG0583	DNA-binding transcription factor activity
HV304_RS17530	COG3969	phosphoadenosine phosphosulfate
HV304_RS17535	COG1475	DNA binding
HV304_RS17540	COG0436	Aminotransferase
HV304_RS17545	COG0371	Dehydrogenase
HV304_RS17550	COG2879	small protein
HV304_RS17555	COG1966	Carbon starvation protein
HV304_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS17570	COG1535	isochorismatase
HV304_RS17570	COG3433	isochorismatase activity
HV304_RS17575	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV304_RS17580	COG1169	isochorismate synthase
HV304_RS17585	COG4592	Periplasmic binding protein
HV304_RS17595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS17600	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS17605	COG1120	ATPase activity
HV304_RS17610	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV304_RS17615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV304_RS17615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV304_RS17620	COG3251	PFAM MbtH domain protein
HV304_RS17625	COG2382	esterase
HV304_RS17630	COG4771	TonB-dependent receptor
HV304_RS17670	COG2315	Protein conserved in bacteria
HV304_RS17680	COG0668	transmembrane transport
HV304_RS17685	COG1113	amino acid transport
HV304_RS17695	COG3039	Transposase
HV304_RS17710	COG3005	denitrification pathway
HV304_RS17715	COG0745	RESPONSE REGULATOR receiver
HV304_RS17720	COG1879	ABC-type sugar transport system periplasmic component
HV304_RS17725	COG0784	Response regulator, receiver
HV304_RS17725	COG2205	protein histidine kinase activity
HV304_RS17725	COG2198	Histidine kinase
HV304_RS17735	COG3039	Transposase
HV304_RS17745	COG2501	S4 domain
HV304_RS17765	COG1988	membrane-bound metal-dependent
HV304_RS17775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV304_RS17785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV304_RS17790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV304_RS17810	COG1464	Belongs to the NlpA lipoprotein family
HV304_RS17815	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV304_RS17820	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV304_RS17825	COG4181	ATPase activity
HV304_RS17830	COG2755	lipolytic protein G-D-S-L family
HV304_RS17835	COG0300	oxidoreductase activity
HV304_RS17840	COG3118	belongs to the thioredoxin family
HV304_RS17845	COG0390	transport system, permease component
HV304_RS17850	COG4619	ABC transporter
HV304_RS17855	COG0330	HflC and HflK could
HV304_RS17860	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV304_RS17880	COG4771	TonB-dependent receptor
HV304_RS17895	COG3721	Heme iron utilization protein
HV304_RS17905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS17920	COG3735	TraB family
HV304_RS17925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV304_RS17935	COG2223	nitrite transmembrane transporter activity
HV304_RS17940	COG4651	solute:proton antiporter activity
HV304_RS17940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV304_RS17945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS17990	COG2832	Protein of unknown function (DUF454)
HV304_RS17995	COG3923	Primosomal replication protein n
HV304_RS18005	COG1196	nuclear chromosome segregation
HV304_RS18005	COG3264	Mechanosensitive ion channel
HV304_RS18010	COG1309	transcriptional regulator
HV304_RS18015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV304_RS18020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV304_RS18035	COG0110	maltose O-acetyltransferase activity
HV304_RS18055	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV304_RS18060	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV304_RS18065	COG2364	Membrane
HV304_RS18070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV304_RS18090	COG3695	enzyme binding
HV304_RS18095	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV304_RS18100	COG1946	Acyl-CoA thioesterase
HV304_RS18105	COG0004	ammonium transporteR
HV304_RS18110	COG0347	Belongs to the P(II) protein family
HV304_RS18115	COG1132	(ABC) transporter
HV304_RS18120	COG1132	(ABC) transporter
HV304_RS18125	COG1522	sequence-specific DNA binding
HV304_RS18140	COG4533	DNA binding
HV304_RS18150	COG0824	Thioesterase
HV304_RS18155	COG1555	photosystem II stabilization
HV304_RS18160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV304_RS18165	COG0776	regulation of translation
HV304_RS18170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV304_RS18190	COG0271	Belongs to the BolA IbaG family
HV304_RS18195	COG3056	Lipoprotein
HV304_RS18200	COG2223	nitrite transmembrane transporter activity
HV304_RS18205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV304_RS18210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV304_RS18215	COG1845	cytochrome c oxidase, subunit III
HV304_RS18220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV304_RS18230	COG2814	Major facilitator Superfamily
HV304_RS18265	COG0142	geranyltranstransferase activity
HV304_RS18275	COG0667	Aldo Keto reductase
HV304_RS18280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV304_RS18285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV304_RS18300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV304_RS18300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV304_RS18310	COG4238	major outer membrane lipoprotein
HV304_RS18330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV304_RS18335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV304_RS18340	COG1862	Preprotein translocase
HV304_RS18350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV304_RS18360	COG0450	alkyl hydroperoxide reductase
HV304_RS18365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV304_RS18375	COG1335	isochorismatase
HV304_RS18380	COG0583	DNA-binding transcription factor activity
HV304_RS18385	COG0366	Alpha amylase catalytic
HV304_RS18400	COG5002	protein histidine kinase activity
HV304_RS18410	COG0420	3'-5' exonuclease activity
HV304_RS18415	COG0419	ATPase involved in DNA repair
HV304_RS18420	COG2814	Major facilitator Superfamily
HV304_RS18425	COG1940	carbohydrate kinase activity
HV304_RS18440	COG4126	flavin adenine dinucleotide binding
HV304_RS18460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV304_RS18465	COG3706	GGDEF domain
HV304_RS18475	COG1785	Belongs to the alkaline phosphatase family
HV304_RS18490	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV304_RS18510	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV304_RS18515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV304_RS18520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV304_RS18530	COG0113	porphobilinogen synthase activity
HV304_RS18535	COG2175	clavaminate synthase activity
HV304_RS18540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV304_RS18545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV304_RS18550	COG4521	taurine ABC transporter
HV304_RS18565	COG2271	Major facilitator Superfamily
HV304_RS18570	COG1840	ABC-type Fe3 transport system, periplasmic component
HV304_RS18580	COG3842	ATPase activity
HV304_RS18585	COG2040	homocysteine
HV304_RS18590	COG0833	amino acid
HV304_RS18595	COG2814	Major facilitator Superfamily
HV304_RS18630	COG1414	Transcriptional regulator
HV304_RS18660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV304_RS18675	COG1609	Transcriptional regulator
HV304_RS18700	COG2079	MmgE PrpD family protein
HV304_RS18705	COG0372	Belongs to the citrate synthase family
HV304_RS18715	COG3829	transcription factor binding
HV304_RS18725	COG1280	lysine exporter protein (LysE YggA)
HV304_RS18730	COG3706	GGDEF domain
HV304_RS18735	COG0348	domain, Protein
HV304_RS18740	COG1737	Transcriptional regulator
HV304_RS18750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS18755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS18760	COG1120	ATPase activity
HV304_RS18765	COG4774	siderophore transport
HV304_RS18785	COG0583	DNA-binding transcription factor activity
HV304_RS18805	COG3069	C4-dicarboxylate transmembrane transporter activity
HV304_RS18810	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV304_RS18820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV304_RS18825	COG0693	protein deglycase activity
HV304_RS18830	COG3039	Transposase
HV304_RS18835	COG2200	EAL domain
HV304_RS18845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV304_RS18850	COG3039	Transposase
HV304_RS18900	COG2826	transposase and inactivated derivatives, IS30 family
HV304_RS18920	COG3596	GTP binding
HV304_RS18930	COG2378	regulation of single-species biofilm formation
HV304_RS18960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV304_RS18975	COG2003	Belongs to the UPF0758 family
HV304_RS19015	COG3039	Transposase
HV304_RS19025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV304_RS19035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV304_RS19060	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV304_RS19080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HV304_RS19085	COG1191	sigma factor activity
HV304_RS19110	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV304_RS19115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV304_RS19135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV304_RS19140	COG1256	bacterial-type flagellum assembly
HV304_RS19140	COG4786	Flagellar basal body rod
HV304_RS19160	COG4786	Flagellar basal body rod
HV304_RS19165	COG4787	bacterial-type flagellum-dependent cell motility
HV304_RS19180	COG1558	bacterial-type flagellum-dependent cell motility
HV304_RS19215	COG3039	Transposase
HV304_RS19260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV304_RS19270	COG1677	Flagellar hook-basal body complex protein FliE
HV304_RS19295	COG1987	bacterial-type flagellum assembly
HV304_RS19300	COG1684	flagellar biosynthetic protein fliR
HV304_RS19315	COG0791	NLP P60 protein
HV304_RS19320	COG3034	peptidoglycan biosynthetic process
HV304_RS19325	COG0121	glutamine amidotransferase
HV304_RS19335	COG1960	acyl-CoA dehydrogenase activity
HV304_RS19340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV304_RS19350	COG2200	EAL domain
HV304_RS19365	COG3539	Fimbrial protein
HV304_RS19375	COG3121	Chaperone
HV304_RS19380	COG3188	usher protein
HV304_RS19390	COG3539	Fimbrial protein
HV304_RS19395	COG0745	RESPONSE REGULATOR receiver
HV304_RS19410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV304_RS19420	COG2226	methyltransferase
HV304_RS19430	COG0741	lytic transglycosylase activity
HV304_RS19430	COG1388	LysM domain
HV304_RS19435	COG2226	methyltransferase
HV304_RS19445	COG2814	Major facilitator Superfamily
HV304_RS19450	COG0583	DNA-binding transcription factor activity
HV304_RS19485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV304_RS19495	COG2011	ABC-type metal ion transport system permease component
HV304_RS19500	COG1464	Belongs to the NlpA lipoprotein family
HV304_RS19510	COG1720	tRNA m6t6A37 methyltransferase activity
HV304_RS19520	COG3015	lipoprotein NlpE involved in copper resistance
HV304_RS19525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV304_RS19540	COG4568	rho-dependent transcription termination
HV304_RS19550	COG0346	lactoylglutathione lyase activity
HV304_RS19590	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV304_RS19595	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV304_RS19610	COG0575	Belongs to the CDS family
HV304_RS19620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV304_RS19665	COG3835	regulator
HV304_RS19690	COG2860	membrane
HV304_RS19715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV304_RS19720	COG1120	ATPase activity
HV304_RS19725	COG4774	siderophore transport
HV304_RS19730	COG3539	Fimbrial protein
HV304_RS19735	COG3188	usher protein
HV304_RS19740	COG3121	Chaperone
HV304_RS19750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV304_RS19755	COG1643	Atp-dependent helicase
HV304_RS19760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV304_RS19780	COG0617	tRNA 3'-terminal CCA addition
HV304_RS19785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV304_RS19805	COG0726	polysaccharide deacetylase
HV304_RS19810	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS19815	COG0842	Transport permease protein
HV304_RS19820	COG1131	(ABC) transporter
HV304_RS19825	COG0288	reversible hydration of carbon dioxide
HV304_RS19830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV304_RS19860	COG3064	Membrane
HV304_RS19875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV304_RS19880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV304_RS19885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV304_RS19900	COG2211	Major facilitator Superfamily
HV304_RS19905	COG3940	Belongs to the glycosyl hydrolase 43 family
HV304_RS19910	COG3725	Membrane protein required for beta-lactamase induction
HV304_RS19925	COG4969	Belongs to the N-Me-Phe pilin family
HV304_RS19930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV304_RS19935	COG1459	type II secretion system
HV304_RS19945	COG0237	dephospho-CoA kinase activity
HV304_RS19960	COG0494	nUDIX hydrolase
HV304_RS19980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV304_RS19985	COG0849	cell division
HV304_RS19995	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV304_RS20010	COG0772	Belongs to the SEDS family
HV304_RS20015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV304_RS20025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV304_RS20030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV304_RS20035	COG0768	penicillin binding
HV304_RS20065	COG0028	Belongs to the TPP enzyme family
HV304_RS20100	COG1609	Transcriptional regulator
HV304_RS20110	COG1028	Short-chain dehydrogenase reductase Sdr
HV304_RS20115	COG2814	Major facilitator Superfamily
HV304_RS20135	COG1178	ABC-type Fe3 transport system permease component
HV304_RS20145	COG0586	Pfam SNARE associated Golgi protein
HV304_RS20165	COG0235	Class ii aldolase
HV304_RS20175	COG0417	DNA replication proofreading
HV304_RS20185	COG0564	pseudouridine synthase activity
HV304_RS20195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV304_RS20245	COG2271	Major facilitator Superfamily
HV304_RS20255	COG0644	oxidoreductase
HV304_RS20270	COG3039	Transposase
HV304_RS20315	COG0505	Belongs to the CarA family
HV304_RS20335	COG1047	Peptidyl-prolyl cis-trans
HV304_RS20350	COG0196	riboflavin kinase activity
HV304_RS20370	COG0583	DNA-binding transcription factor activity
HV304_RS20385	COG0443	Heat shock 70 kDa protein
HV304_RS20395	COG4735	regulation of single-species biofilm formation
HV304_RS20400	COG1584	GPR1 FUN34 yaaH family protein
HV304_RS20410	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV304_RS20420	COG1115	amino acid carrier protein
HV304_RS20430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV304_RS20440	COG0460	homoserine dehydrogenase
HV304_RS20440	COG0527	aspartate kinase activity
HV304_RS20450	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV304_RS20460	COG0745	RESPONSE REGULATOR receiver
HV304_RS20465	COG4452	Inner membrane protein CreD
HV304_RS20470	COG2205	protein histidine kinase activity
HV304_RS20475	COG0745	RESPONSE REGULATOR receiver
HV304_RS20480	COG3045	CreA protein
HV304_RS20485	COG3708	Transcriptional regulator
HV304_RS20485	COG2207	Transcriptional regulator
HV304_RS20505	COG0741	lytic transglycosylase activity
HV304_RS20510	COG0488	(ABC) transporter
HV304_RS20525	COG0560	Phosphoserine phosphatase
HV304_RS20530	COG3726	membrane protein affecting hemolysin expression
HV304_RS20560	COG1328	CTP reductase activity
HV304_RS20565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV304_RS20570	COG0084	hydrolase, TatD family'
HV304_RS20575	COG4667	esterase of the alpha-beta hydrolase superfamily
HV304_RS20580	COG5487	UPF0391 membrane protein
HV304_RS20585	COG2823	Periplasmic or secreted lipoprotein
HV304_RS20595	COG1011	Hydrolase
HV304_RS20600	COG0456	acetyltransferase
HV304_RS20605	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV304_RS20635	COG3706	GGDEF domain
HV304_RS20640	COG4114	ferric iron reductase
HV304_RS20645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV304_RS20650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV304_RS20655	COG2197	response regulator
HV304_RS20665	COG2966	Psort location CytoplasmicMembrane, score
HV304_RS20680	COG1484	DNA-dependent DNA replication
HV304_RS20700	COG1063	alcohol dehydrogenase
HV304_RS20705	COG1802	Transcriptional regulator
HV304_RS20710	COG2271	Major facilitator Superfamily
HV304_RS20720	COG0840	transmembrane signaling receptor activity
HV304_RS20730	COG1966	Carbon starvation protein
HV304_RS20735	COG2879	small protein
HV304_RS20740	COG0523	cobalamin synthesis protein
HV304_RS20750	COG1566	PFAM secretion protein HlyD family protein
HV304_RS20760	COG5457	Domain of unknown function (DUF1127)
HV304_RS20765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV304_RS20770	COG5464	transposase or invertase
HV304_RS20790	COG0626	cystathionine gamma-synthase activity
HV304_RS20795	COG1301	dicarboxylic acid transport
HV304_RS20800	COG0583	DNA-binding transcription factor activity
HV304_RS20805	COG2733	membrane
HV304_RS20815	COG0477	Major facilitator Superfamily
HV304_RS20835	COG2186	Transcriptional regulator
HV304_RS20840	COG0246	Mannitol dehydrogenase
HV304_RS20850	COG2610	gluconate transmembrane transporter activity
HV304_RS20855	COG1556	Lactate utilization protein
HV304_RS20860	COG1139	Iron-sulfur cluster binding protein
HV304_RS20865	COG0247	lactate metabolic process
HV304_RS20870	COG1620	l-lactate permease
HV304_RS20915	COG3039	Transposase
HV304_RS20920	COG0210	DNA helicase
HV304_RS20940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV304_RS20995	COG0582	viral genome integration into host DNA
HV304_RS21005	COG1064	alcohol dehydrogenase
HV304_RS21010	COG0433	COG0433 Predicted ATPase
HV304_RS21015	COG0795	lipopolysaccharide-transporting ATPase activity
HV304_RS21020	COG0795	lipopolysaccharide-transporting ATPase activity
HV304_RS21030	COG2927	DNA polymerase III (CHI subunit)
HV304_RS21035	COG0525	valine-tRNA ligase activity
HV304_RS21040	COG4269	membrane
HV304_RS21070	COG2731	YhcH YjgK YiaL family protein
HV304_RS21090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV304_RS21095	COG1288	antiporter activity
HV304_RS21100	COG1438	arginine binding
HV304_RS21145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV304_RS21160	COG1263	PTS System
HV304_RS21160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS21165	COG0366	Alpha amylase catalytic
HV304_RS21180	COG2026	Addiction module toxin, RelE StbE family
HV304_RS21185	COG3077	Addiction module antitoxin, RelB DinJ family
HV304_RS21190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS21190	COG3711	transcriptional antiterminator
HV304_RS21205	COG3964	amidohydrolase
HV304_RS21240	COG0312	modulator of DNA gyrase
HV304_RS21250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV304_RS21260	COG0840	transmembrane signaling receptor activity
HV304_RS21265	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV304_RS21270	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV304_RS21275	COG1129	ABC transporter
HV304_RS21280	COG1879	ABC-type sugar transport system periplasmic component
HV304_RS21290	COG2105	PFAM AIG2 family protein
HV304_RS21295	COG2911	Protein conserved in bacteria
HV304_RS21300	COG0729	surface antigen
HV304_RS21310	COG1253	flavin adenine dinucleotide binding
HV304_RS21320	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV304_RS21325	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV304_RS21335	COG1733	regulation of RNA biosynthetic process
HV304_RS21340	COG0702	epimerase
HV304_RS21350	COG0697	spore germination
HV304_RS21355	COG0840	transmembrane signaling receptor activity
HV304_RS21365	COG1113	amino acid transport
HV304_RS21370	COG0545	Peptidyl-prolyl cis-trans isomerase
HV304_RS21375	COG3061	Opacity-associated protein A
HV304_RS21390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV304_RS21405	COG0730	response to heat
HV304_RS21455	COG1073	alpha beta
HV304_RS21460	COG3650	response to hydrogen peroxide
HV304_RS21470	COG1960	acyl-CoA dehydrogenase activity
HV304_RS21475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV304_RS21480	COG0557	exoribonuclease II activity
HV304_RS21495	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV304_RS21500	COG0330	HflC and HflK could
HV304_RS21505	COG0330	HflC and HflK could
HV304_RS21510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV304_RS21515	COG1923	regulation of RNA biosynthetic process
HV304_RS21530	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV304_RS21535	COG0802	atpase or kinase
HV304_RS21540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV304_RS21540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV304_RS21545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV304_RS21580	COG1511	domain protein
HV304_RS21580	COG3264	Mechanosensitive ion channel
HV304_RS21595	COG1053	succinate dehydrogenase
HV304_RS21600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV304_RS21655	COG1509	lysine 2,3-aminomutase activity
HV304_RS21680	COG0531	amino acid
HV304_RS21685	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV304_RS21690	COG1027	Aspartate ammonia-lyase
HV304_RS21695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV304_RS21710	COG1309	transcriptional regulator
HV304_RS21740	COG4974	Belongs to the 'phage' integrase family
HV304_RS21775	COG4735	regulation of single-species biofilm formation
HV304_RS21780	COG2378	regulation of single-species biofilm formation
HV304_RS21790	COG3039	Transposase
HV304_RS21800	COG0366	Alpha amylase catalytic
HV304_RS21805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV304_RS21805	COG1263	PTS System
HV304_RS21805	COG2190	(PTS) system
HV304_RS21815	COG3039	Transposase
HV304_RS21830	COG3039	Transposase
HV304_RS21835	COG0318	PFAM AMP-dependent synthetase and ligase
HV304_RS21865	COG3290	protein histidine kinase activity
HV304_RS21870	COG4565	transcriptional regulatory protein
HV304_RS21875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV304_RS21880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS21880	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV304_RS21885	COG3647	Membrane
HV304_RS21895	COG2211	Major facilitator Superfamily
HV304_RS21900	COG1486	melibiose metabolic process
HV304_RS21905	COG2169	Transcriptional regulator
HV304_RS21910	COG1982	Orn Lys Arg decarboxylase major
HV304_RS21915	COG2207	Transcriptional regulator
HV304_RS21920	COG0531	amino acid
HV304_RS21960	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV304_RS21965	COG2824	Alkylphosphonate utilization operon protein PhnA
HV304_RS21970	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV304_RS21975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV304_RS21980	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV304_RS21985	COG3639	organic phosphonate transmembrane transporter activity
HV304_RS21990	COG2188	Transcriptional regulator
HV304_RS21995	COG3624	Phosphonate C-P lyase system protein PhnG
HV304_RS22000	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV304_RS22005	COG3626	phosphonate metabolism
HV304_RS22010	COG3627	carbon phosphorus lyase activity
HV304_RS22015	COG4107	phosphonate C-P lyase system protein PhnK
HV304_RS22020	COG4778	phosphonate C-P lyase system protein PhnL
HV304_RS22025	COG3454	Phosphonate metabolism
HV304_RS22035	COG0456	acetyltransferase
HV304_RS22040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV304_RS22045	COG3093	addiction module antidote protein HigA
HV304_RS22050	COG3549	Plasmid maintenance system killer
HV304_RS22065	COG1129	ABC transporter
HV304_RS22070	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV304_RS22095	COG0745	RESPONSE REGULATOR receiver
HV304_RS22100	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV304_RS22110	COG1566	PFAM secretion protein HlyD family protein
HV304_RS22115	COG1289	transmembrane transporter activity
HV304_RS22120	COG1538	Outer membrane efflux protein
HV304_RS22130	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV304_RS22135	COG1301	dicarboxylic acid transport
HV304_RS22140	COG4235	cytochrome complex assembly
HV304_RS22145	COG3088	subunit of a heme lyase
HV304_RS22150	COG1138	Cytochrome C-type biogenesis protein
HV304_RS22155	COG3301	Polysulphide reductase, NrfD
HV304_RS22160	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS22165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV304_RS22175	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV304_RS22200	COG3162	membrane
HV304_RS22210	COG1346	cytolysis
HV304_RS22215	COG1380	Effector of murein hydrolase LrgA
HV304_RS22220	COG0583	DNA-binding transcription factor activity
HV304_RS22225	COG0025	NhaP-type Na H and K H
HV304_RS22230	COG2252	PERMEase
HV304_RS22235	COG0789	Transcriptional regulator
HV304_RS22245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV304_RS22270	COG0629	single-stranded DNA binding
HV304_RS22275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV304_RS22280	COG2315	Protein conserved in bacteria
HV304_RS22285	COG3700	Belongs to the class B bacterial acid phosphatase family
HV304_RS22290	COG1448	Aminotransferase
HV304_RS22300	COG0305	Participates in initiation and elongation during chromosome replication
HV304_RS22315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV304_RS22325	COG0735	belongs to the Fur family
HV304_RS22330	COG3237	CsbD-like
HV304_RS22335	COG0534	Mate efflux family protein
HV304_RS22345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV304_RS22380	COG2182	Extracellular solute-binding protein
HV304_RS22395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV304_RS22400	COG1757	Na H antiporter
HV304_RS22405	COG3223	Belongs to the PsiE family
HV304_RS22410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV304_RS22415	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV304_RS22440	COG0527	aspartate kinase activity
HV304_RS22445	COG3541	Predicted nucleotidyltransferase
HV304_RS22455	COG4650	regulator
HV304_RS22475	COG1187	pseudouridine synthase activity
HV304_RS22515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV304_RS22530	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV304_RS22555	COG0646	methionine synthase
HV304_RS22555	COG1410	methionine synthase
HV304_RS22565	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV304_RS22575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV304_RS22585	COG0456	acetyltransferase
HV304_RS22610	COG0151	Belongs to the GarS family
HV304_RS22620	COG4191	Histidine kinase
HV304_RS22675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV304_RS22680	COG2104	thiamine diphosphate biosynthetic process
HV304_RS22695	COG1278	Cold shock
HV304_RS22705	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV304_RS22740	COG0250	Participates in transcription elongation, termination and antitermination
HV304_RS22785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV304_RS22845	COG0583	DNA-binding transcription factor activity
HV304_RS22880	COG2207	Transcriptional regulator
HV304_RS22890	COG0371	Dehydrogenase
HV304_RS22900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV304_RS22905	COG0583	DNA-binding transcription factor activity
HV304_RS22915	COG0737	Belongs to the 5'-nucleotidase family
HV304_RS22925	COG0460	homoserine dehydrogenase
HV304_RS22925	COG0527	aspartate kinase activity
HV304_RS22930	COG0626	cystathionine gamma-synthase activity
HV304_RS22940	COG2211	Major facilitator Superfamily
HV304_RS22955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV304_RS22960	COG1609	Transcriptional regulator
HV304_RS22965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV304_RS22980	COG1575	Belongs to the MenA family. Type 1 subfamily
HV304_RS22995	COG3074	FtsZ-dependent cytokinesis
HV304_RS23000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV304_RS23010	COG1494	fructose-1,6-bisphosphatase
HV304_RS23020	COG3152	Membrane
HV304_RS23035	COG0471	metal ion transport
HV304_RS23065	COG3678	ATP-independent chaperone mediated protein folding
HV304_RS23070	COG0745	RESPONSE REGULATOR receiver
HV304_RS23075	COG2205	protein histidine kinase activity
HV304_RS23080	COG2258	MOSC domain
HV304_RS23085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV304_RS23130	COG1454	alcohol dehydrogenase
HV304_RS23145	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV304_RS23155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS23160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS23160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV304_RS23165	COG1363	Peptidase, m42
HV304_RS23170	COG3711	transcriptional antiterminator
HV304_RS23170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV304_RS23200	COG0437	4 iron, 4 sulfur cluster binding
HV304_RS23205	COG2864	formate dehydrogenase
HV304_RS23220	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV304_RS23230	COG0456	acetyltransferase
HV304_RS23235	COG1490	D-aminoacyl-tRNA deacylase activity
HV304_RS23245	COG1011	Hydrolase
HV304_RS23250	COG1349	DNA-binding transcription factor activity
HV304_RS23255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS23265	COG3684	Belongs to the aldolase LacD family
HV304_RS23275	COG2017	converts alpha-aldose to the beta-anomer
HV304_RS23280	COG1501	Belongs to the glycosyl hydrolase 31 family
HV304_RS23310	COG3852	Histidine kinase
HV304_RS23315	COG2204	response regulator
HV304_RS23325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV304_RS23345	COG0204	Acyl-transferase
HV304_RS23360	COG3084	Protein conserved in bacteria
HV304_RS23365	COG0746	molybdenum cofactor guanylyltransferase activity
HV304_RS23370	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV304_RS23410	COG1739	Uncharacterized protein family UPF0029
HV304_RS23425	COG0183	Belongs to the thiolase family
HV304_RS23430	COG1609	Transcriptional regulator
HV304_RS23435	COG1940	carbohydrate kinase activity
HV304_RS23460	COG0805	protein transport
HV304_RS23510	COG0583	DNA-binding transcription factor activity
HV304_RS23515	COG0697	spore germination
HV304_RS23520	COG0561	phosphatase activity
HV304_RS23525	COG2267	carboxylic ester hydrolase activity
HV304_RS23530	COG1280	lysine exporter protein (LysE YggA)
HV304_RS23540	COG1280	lysine exporter protein (LysE YggA)
HV304_RS23575	COG1011	Hydrolase
HV304_RS23620	COG2959	enzyme of heme biosynthesis
HV304_RS23625	COG3071	HemY protein
HV304_RS23670	COG2244	polysaccharide biosynthetic process
HV304_RS23675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV304_RS23680	COG0456	acetyltransferase
HV304_RS23685	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV304_RS23700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV304_RS23705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV304_RS23715	COG3118	belongs to the thioredoxin family
HV304_RS23735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV304_RS23755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV304_RS23765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV304_RS23770	COG3978	acetolactate synthase activity
HV304_RS23790	COG3085	chromosome segregation
HV304_RS23830	COG2186	Transcriptional regulator
HV304_RS23835	COG0477	Major facilitator Superfamily
HV304_RS23840	COG1609	Transcriptional regulator
HV304_RS23845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV304_RS23850	COG1879	ABC-type sugar transport system periplasmic component
HV304_RS23855	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV304_RS23865	COG1869	D-ribose catabolic process
HV304_RS23890	COG1522	sequence-specific DNA binding
HV304_RS23895	COG0716	FMN binding
HV304_RS23910	COG3312	ion transport
HV304_RS23935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV304_RS23945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV304_RS23950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV304_RS23965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV304_RS23970	COG0573	inorganic phosphate transmembrane transporter activity
HV304_RS23975	COG0581	inorganic phosphate transmembrane transporter activity
HV304_RS23985	COG0704	Plays a role in the regulation of phosphate uptake
HV304_RS23990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV304_RS23995	COG2252	PERMEase
HV304_RS24000	COG0431	NADPH-dependent FMN reductase
HV304_RS24005	COG2091	lysine biosynthetic process via aminoadipic acid
HV304_RS24040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV304_RS24095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV304_RS24115	COG2433	Pfam Transposase IS66
HV304_RS24120	COG3436	PFAM IS66 Orf2 family protein
HV304_RS24165	COG2826	transposase and inactivated derivatives, IS30 family
HV304_RS24190	COG2801	Transposase and inactivated derivatives
HV304_RS24210	COG3039	Transposase
HV304_RS24245	COG1595	DNA-templated transcription, initiation
HV304_RS24250	COG3712	iron ion homeostasis
HV304_RS24255	COG4772	TonB-dependent receptor
HV304_RS24260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV304_RS24265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS24270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV304_RS24275	COG1120	ATPase activity
HV304_RS24280	COG3436	PFAM IS66 Orf2 family protein
HV304_RS24295	COG1609	Transcriptional regulator
HV304_RS24305	COG2223	nitrite transmembrane transporter activity
HV304_RS24320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV304_RS24340	COG2985	domain, Protein
HV304_RS24355	COG1304	FMN binding
HV304_RS24360	COG3039	Transposase
HV304_RS24365	COG4221	oxidoreductase activity
HV304_RS24370	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HV304_RS24375	COG2814	Major facilitator Superfamily
HV304_RS24380	COG4977	sequence-specific DNA binding
HV304_RS24385	COG2207	Transcriptional regulator
HV304_RS24400	COG2801	Transposase and inactivated derivatives
HV304_RS24410	COG2826	transposase and inactivated derivatives, IS30 family
HV304_RS24430	COG4372	Transposase
HV304_RS24435	COG3436	PFAM IS66 Orf2 family protein
HV304_RS24500	COG1358	cellular component organization or biogenesis
HV304_RS24530	COG4245	von Willebrand factor, type A
HV304_RS24555	COG2826	transposase and inactivated derivatives, IS30 family
HV304_RS24580	COG3039	Transposase
HV304_RS24690	COG2974	May be involved in recombination
HV304_RS24850	COG3423	Transcriptional regulator
HV304_RS24865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV304_RS24870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV304_RS24895	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV304_RS24900	COG0640	Transcriptional regulator
HV304_RS24905	COG0783	Belongs to the Dps family
HV304_RS24920	COG1342	Belongs to the UPF0251 family
HV304_RS24935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV304_RS24975	COG0789	Transcriptional regulator
HV304_RS24995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV304_RS25040	COG2948	multi-organism process
HV304_RS25050	COG0583	DNA-binding transcription factor activity
HV304_RS25055	COG1846	Transcriptional regulator
HV304_RS25075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HV304_RS25090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV304_RS25100	COG0583	DNA-binding transcription factor activity
HV304_RS25110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV304_RS25115	COG0625	glutathione transferase activity
HV304_RS25145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV304_RS25185	COG0033	Phosphoglucomutase
HV304_RS25190	COG0058	SHG alpha-glucan phosphorylase activity
HV304_RS25220	COG4644	lycopene metabolic process
HV304_RS25240	COG0589	response to stress
HV304_RS25250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV304_RS25265	COG0789	Transcriptional regulator
HV304_RS25305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV304_RS25315	COG1528	Iron-storage protein
HV304_RS25325	COG3039	Transposase
HV304_RS25390	COG1127	ABC transporter
HV304_RS25395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV304_RS25455	COG3039	Transposase
HV304_RS25500	COG2433	Pfam Transposase IS66
HV304_RS25505	COG3436	PFAM IS66 Orf2 family protein
HV304_RS25570	COG1199	ATP-dependent helicase activity
HV304_RS25720	COG5654	RES domain protein
HV304_RS25725	COG5642	Protein of unknown function (DUF2384)
HV304_RS25770	COG1192	Involved in chromosome partitioning
HV304_RS25825	COG0305	Participates in initiation and elongation during chromosome replication
HV304_RS25935	COG2944	sequence-specific DNA binding
HV304_RS25980	COG2916	Histone family protein nucleoid-structuring protein H-NS
HV304_RS26115	COG1192	Involved in chromosome partitioning
HV304_RS26275	COG0640	Transcriptional regulator
HV304_RS26280	COG1230	cation diffusion facilitator family transporter
HV304_RS26285	COG1937	Protein conserved in bacteria