locus-tag	class	description
HV319_RS00010	COG0592	DNA-directed DNA polymerase activity
HV319_RS00025	COG0561	phosphatase activity
HV319_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV319_RS00040	COG5645	(Lipo)protein
HV319_RS00060	COG2149	membrane
HV319_RS00070	COG0641	radical SAM
HV319_RS00080	COG2610	gluconate transmembrane transporter activity
HV319_RS00085	COG0583	DNA-binding transcription factor activity
HV319_RS00095	COG2814	Major facilitator Superfamily
HV319_RS00115	COG0028	Belongs to the TPP enzyme family
HV319_RS00120	COG0440	acetolactate synthase activity
HV319_RS00125	COG1349	DNA-binding transcription factor activity
HV319_RS00135	COG0738	Major facilitator superfamily
HV319_RS00145	COG2197	response regulator
HV319_RS00185	COG2723	6-phospho-beta-galactosidase activity
HV319_RS00210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS00210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS00215	COG3715	PTS system
HV319_RS00220	COG3716	PTS system mannose fructose sorbose family IID component
HV319_RS00235	COG5464	transposase or invertase
HV319_RS00240	COG1464	Belongs to the NlpA lipoprotein family
HV319_RS00245	COG0697	spore germination
HV319_RS00255	COG0604	alcohol dehydrogenase
HV319_RS00260	COG0583	DNA-binding transcription factor activity
HV319_RS00280	COG2771	luxR family
HV319_RS00320	COG2211	Major facilitator Superfamily
HV319_RS00325	COG1501	Belongs to the glycosyl hydrolase 31 family
HV319_RS00330	COG3711	transcriptional antiterminator
HV319_RS00335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS00335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS00335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS00340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS00345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS00345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS00355	COG0191	fructose-bisphosphate aldolase activity
HV319_RS00365	COG2982	Protein involved in outer membrane biogenesis
HV319_RS00370	COG2233	PERMEase
HV319_RS00375	COG0786	glutamate:sodium symporter activity
HV319_RS00380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV319_RS00385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV319_RS00390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV319_RS00410	COG2860	membrane
HV319_RS00415	COG1561	YicC-like family, N-terminal region
HV319_RS00440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV319_RS00455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV319_RS00470	COG1519	Transferase
HV319_RS00475	COG0438	transferase activity, transferring glycosyl groups
HV319_RS00480	COG0515	serine threonine protein kinase
HV319_RS00485	COG1442	glycosyl transferase family 8
HV319_RS00490	COG1442	glycosyl transferase family 8
HV319_RS00500	COG0859	PFAM glycosyl transferase family 9
HV319_RS00505	COG1215	transferase activity, transferring glycosyl groups
HV319_RS00510	COG3307	-O-antigen
HV319_RS00520	COG0859	PFAM glycosyl transferase family 9
HV319_RS00530	COG0156	8-amino-7-oxononanoate synthase activity
HV319_RS00540	COG1216	Glycosyl transferase, family 2
HV319_RS00545	COG2861	carbohydrate metabolic process
HV319_RS00550	COG4942	peptidase
HV319_RS00560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV319_RS00565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV319_RS00580	COG1045	serine acetyltransferase
HV319_RS00585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV319_RS00590	COG2271	Major facilitator Superfamily
HV319_RS00600	COG2186	Transcriptional regulator
HV319_RS00620	COG3722	fumarate hydratase activity
HV319_RS00630	COG2213	PTS system mannitol-specific
HV319_RS00630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS00640	COG1566	PFAM secretion protein HlyD family protein
HV319_RS00645	COG0625	glutathione transferase activity
HV319_RS00655	COG3276	selenocysteine insertion sequence binding
HV319_RS00660	COG1454	alcohol dehydrogenase
HV319_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS00680	COG1566	PFAM secretion protein HlyD family protein
HV319_RS00685	COG0583	DNA-binding transcription factor activity
HV319_RS00690	COG3713	MltA-interacting MipA family protein
HV319_RS00700	COG2211	Major facilitator Superfamily
HV319_RS00705	COG1917	Cupin 2, conserved barrel domain protein
HV319_RS00705	COG4977	sequence-specific DNA binding
HV319_RS00710	COG0235	Class ii aldolase
HV319_RS00715	COG3623	hexulose-6-phosphate isomerase
HV319_RS00720	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV319_RS00725	COG1070	Carbohydrate kinase
HV319_RS00730	COG2271	Major facilitator Superfamily
HV319_RS00740	COG2731	YhcH YjgK YiaL family protein
HV319_RS00750	COG1414	Transcriptional regulator
HV319_RS00755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV319_RS00760	COG3977	Valine--pyruvate aminotransferase
HV319_RS00765	COG0366	Alpha amylase catalytic
HV319_RS00770	COG2992	FlgJ-related protein
HV319_RS00775	COG2207	Transcriptional regulator
HV319_RS00775	COG1609	Transcriptional regulator
HV319_RS00785	COG1070	Carbohydrate kinase
HV319_RS00790	COG4682	membrane
HV319_RS00795	COG3274	enterobacterial common antigen metabolic process
HV319_RS00820	COG1278	Cold shock
HV319_RS00825	COG2944	sequence-specific DNA binding
HV319_RS00845	COG2814	Major facilitator Superfamily
HV319_RS00850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS00860	COG1609	Transcriptional regulator
HV319_RS00865	COG2885	chlorophyll binding
HV319_RS00870	COG0243	molybdopterin cofactor binding
HV319_RS00875	COG0456	acetyltransferase
HV319_RS00880	COG2818	Glycosylase
HV319_RS00885	COG5571	outer membrane autotransporter
HV319_RS00890	COG2223	nitrite transmembrane transporter activity
HV319_RS00915	COG0747	negative chemotaxis
HV319_RS00920	COG0601	transmembrane transport
HV319_RS00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV319_RS00930	COG0444	Belongs to the ABC transporter superfamily
HV319_RS00935	COG4608	Belongs to the ABC transporter superfamily
HV319_RS00940	COG2204	response regulator
HV319_RS00945	COG0814	amino acid
HV319_RS00950	COG0626	cystathionine gamma-synthase activity
HV319_RS00960	COG2200	EAL domain
HV319_RS00960	COG2199	diguanylate cyclase activity
HV319_RS00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS00980	COG2200	EAL domain
HV319_RS00985	COG2982	Protein involved in outer membrane biogenesis
HV319_RS00990	COG0477	Major facilitator Superfamily
HV319_RS00995	COG1295	ribonuclease BN
HV319_RS01000	COG0583	DNA-binding transcription factor activity
HV319_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS01015	COG2200	EAL domain
HV319_RS01020	COG2197	response regulator
HV319_RS01030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV319_RS01045	COG1858	cytochrome C peroxidase
HV319_RS01055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV319_RS01060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV319_RS01065	COG0339	signal peptide processing
HV319_RS01080	COG1959	2 iron, 2 sulfur cluster binding
HV319_RS01090	COG0589	response to stress
HV319_RS01100	COG0306	phosphate transporter
HV319_RS01105	COG2081	HI0933 family
HV319_RS01190	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS01220	COG0739	heme binding
HV319_RS01230	COG2132	Multicopper oxidase
HV319_RS01235	COG3667	copper resistance
HV319_RS01240	COG2372	response to copper ion
HV319_RS01245	COG1276	copper resistance
HV319_RS01250	COG0745	RESPONSE REGULATOR receiver
HV319_RS01255	COG2205	protein histidine kinase activity
HV319_RS01265	COG2239	Acts as a magnesium transporter
HV319_RS01270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS01275	COG0842	Transport permease protein
HV319_RS01275	COG1129	ABC transporter
HV319_RS01280	COG0842	Transport permease protein
HV319_RS01300	COG2091	lysine biosynthetic process via aminoadipic acid
HV319_RS01305	COG0628	permease
HV319_RS01310	COG0477	Major facilitator Superfamily
HV319_RS01320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV319_RS01335	COG3714	YhhN family
HV319_RS01345	COG3776	membrane
HV319_RS01350	COG0742	ribosomal rna small subunit methyltransferase
HV319_RS01355	COG0552	protein localization to endoplasmic reticulum
HV319_RS01360	COG2884	Cell division ATP-binding protein ftsE
HV319_RS01365	COG2177	Part of the ABC transporter FtsEX involved in
HV319_RS01385	COG0683	leucine binding
HV319_RS01395	COG4177	L-phenylalanine transmembrane transporter activity
HV319_RS01400	COG0411	ABC transporter
HV319_RS01445	COG0584	glycerophosphoryl diester phosphodiesterase
HV319_RS01460	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HV319_RS01475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS01485	COG1247	-acetyltransferase
HV319_RS01490	COG0673	inositol 2-dehydrogenase activity
HV319_RS01495	COG1741	Belongs to the pirin family
HV319_RS01500	COG1609	Transcriptional regulator
HV319_RS01505	COG3265	gluconokinase activity
HV319_RS01510	COG2610	gluconate transmembrane transporter activity
HV319_RS01520	COG2095	MarC family integral membrane protein
HV319_RS01525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV319_RS01550	COG0058	SHG alpha-glucan phosphorylase activity
HV319_RS01555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV319_RS01570	COG1349	DNA-binding transcription factor activity
HV319_RS01580	COG0058	SHG alpha-glucan phosphorylase activity
HV319_RS01585	COG1640	4-alpha-glucanotransferase
HV319_RS01590	COG2610	gluconate transmembrane transporter activity
HV319_RS01600	COG1040	competence protein
HV319_RS01625	COG1918	ferrous iron import across plasma membrane
HV319_RS01630	COG2183	response to ionizing radiation
HV319_RS01635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV319_RS01640	COG0745	RESPONSE REGULATOR receiver
HV319_RS01655	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV319_RS01665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV319_RS01670	COG1011	Hydrolase
HV319_RS01680	COG0494	nUDIX hydrolase
HV319_RS01685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV319_RS01690	COG4972	Pilus assembly protein
HV319_RS01695	COG3166	PFAM Fimbrial assembly family protein
HV319_RS01710	COG4796	Type ii and iii secretion system protein
HV319_RS01725	COG3266	domain, Protein
HV319_RS01730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV319_RS01735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV319_RS01745	COG0180	Tryptophanyl-tRNA synthetase
HV319_RS01750	COG2188	Transcriptional regulator
HV319_RS01760	COG3457	Alanine racemase
HV319_RS01765	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HV319_RS01770	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HV319_RS01785	COG0626	cystathionine gamma-synthase activity
HV319_RS01805	COG2146	nitrite reductase [NAD(P)H] activity
HV319_RS01810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV319_RS01835	COG0512	Glutamine amidotransferase of anthranilate synthase
HV319_RS01840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV319_RS01845	COG1289	transmembrane transporter activity
HV319_RS01855	COG1765	OsmC-like protein
HV319_RS01860	COG3954	Phosphoribulokinase
HV319_RS01870	COG0429	hydrolase of the alpha beta-hydrolase fold
HV319_RS01880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HV319_RS01890	COG0488	(ABC) transporter
HV319_RS01905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV319_RS01910	COG1047	Peptidyl-prolyl cis-trans
HV319_RS01920	COG0545	Peptidyl-prolyl cis-trans isomerase
HV319_RS01925	COG2964	Protein conserved in bacteria
HV319_RS01950	COG0049	tRNA binding
HV319_RS01980	COG0051	transcription antitermination factor activity, RNA binding
HV319_RS01990	COG0088	Forms part of the polypeptide exit tunnel
HV319_RS02005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV319_RS02080	COG0200	Binds to the 23S rRNA
HV319_RS02085	COG0201	protein transport
HV319_RS02100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV319_RS02125	COG0789	Transcriptional regulator
HV319_RS02130	COG3036	rescue of stalled ribosome
HV319_RS02140	COG0569	domain protein
HV319_RS02160	COG0758	DNA mediated transformation
HV319_RS02170	COG0551	DNA topoisomerase type I activity
HV319_RS02180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV319_RS02190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV319_RS02230	COG1126	abc transporter atp-binding protein
HV319_RS02235	COG0765	amino acid transport
HV319_RS02240	COG4597	amino acid ABC transporter
HV319_RS02245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV319_RS02255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV319_RS02260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS02265	COG1309	transcriptional regulator
HV319_RS02275	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV319_RS02315	COG4145	pantothenate transmembrane transporter activity
HV319_RS02320	COG3924	membrane
HV319_RS02325	COG0439	Biotin carboxylase
HV319_RS02330	COG0511	ligase activity, forming carbon-carbon bonds
HV319_RS02345	COG0604	alcohol dehydrogenase
HV319_RS02350	COG2200	EAL domain
HV319_RS02350	COG2199	diguanylate cyclase activity
HV319_RS02360	COG1077	Cell shape determining protein MreB Mrl
HV319_RS02365	COG1792	Involved in formation and maintenance of cell shape
HV319_RS02370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV319_RS02380	COG1530	ribonuclease E activity
HV319_RS02385	COG3164	Protein of unknown function
HV319_RS02390	COG0312	modulator of DNA gyrase
HV319_RS02395	COG0583	DNA-binding transcription factor activity
HV319_RS02415	COG2732	(Barnase) inhibitor
HV319_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV319_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV319_RS02445	COG3105	Protein conserved in bacteria
HV319_RS02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV319_RS02465	COG0625	glutathione transferase activity
HV319_RS02470	COG2969	positive regulation of protein catabolic process
HV319_RS02475	COG3069	C4-dicarboxylate transmembrane transporter activity
HV319_RS02500	COG2731	YhcH YjgK YiaL family protein
HV319_RS02505	COG0402	S-adenosylhomocysteine deaminase activity
HV319_RS02510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV319_RS02515	COG4804	nuclease activity
HV319_RS02520	COG0493	'glutamate synthase
HV319_RS02525	COG0067	glutamate synthase
HV319_RS02525	COG0070	glutamate synthase
HV319_RS02525	COG0069	glutamate synthase activity
HV319_RS02530	COG1242	4 iron, 4 sulfur cluster binding
HV319_RS02535	COG0784	Response regulator, receiver
HV319_RS02535	COG2198	Histidine kinase
HV319_RS02535	COG5002	protein histidine kinase activity
HV319_RS02540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV319_RS02550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS02565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV319_RS02575	COG1137	ATPase activity
HV319_RS02580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV319_RS02585	COG3117	lipopolysaccharide transmembrane transporter activity
HV319_RS02590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV319_RS02600	COG0530	calcium, potassium:sodium antiporter activity
HV319_RS02605	COG1127	ABC transporter
HV319_RS02610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV319_RS02615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV319_RS02620	COG2854	intermembrane phospholipid transfer
HV319_RS02625	COG3113	response to antibiotic
HV319_RS02630	COG5007	Belongs to the BolA IbaG family
HV319_RS02640	COG3423	Transcriptional regulator
HV319_RS02645	COG0142	geranyltranstransferase activity
HV319_RS02650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV319_RS02655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV319_RS02660	COG0697	spore germination
HV319_RS02670	COG2027	D-alanyl-D-alanine carboxypeptidase
HV319_RS02680	COG1534	Rna-binding protein
HV319_RS02690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV319_RS02695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV319_RS02705	COG3069	C4-dicarboxylate transmembrane transporter activity
HV319_RS02710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV319_RS02715	COG0583	DNA-binding transcription factor activity
HV319_RS02720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV319_RS02745	COG0195	Participates in both transcription termination and antitermination
HV319_RS02750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV319_RS02755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV319_RS02785	COG0513	Belongs to the DEAD box helicase family
HV319_RS02790	COG0814	amino acid
HV319_RS02795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV319_RS02800	COG0826	peptidase U32
HV319_RS02805	COG0826	peptidase U32
HV319_RS02810	COG3154	lipid carrier protein
HV319_RS02815	COG3153	acetyltransferase
HV319_RS02830	COG0702	epimerase
HV319_RS02835	COG2823	Periplasmic or secreted lipoprotein
HV319_RS02855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV319_RS02865	COG2222	sugar isomerase
HV319_RS02870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV319_RS02875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS02880	COG3716	PTS system mannose fructose sorbose family IID component
HV319_RS02890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS02900	COG1349	DNA-binding transcription factor activity
HV319_RS02905	COG1349	DNA-binding transcription factor activity
HV319_RS02910	COG1940	carbohydrate kinase activity
HV319_RS02915	COG0673	inositol 2-dehydrogenase activity
HV319_RS02920	COG3842	ATPase activity
HV319_RS02925	COG0395	ABC-type sugar transport system, permease component
HV319_RS02930	COG1175	transmembrane transport
HV319_RS02940	COG2721	sulfolactate sulfo-lyase activity
HV319_RS02945	COG2271	Major facilitator Superfamily
HV319_RS02955	COG2084	Dehydrogenase
HV319_RS02960	COG1929	Belongs to the glycerate kinase type-1 family
HV319_RS03005	COG0583	DNA-binding transcription factor activity
HV319_RS03035	COG1882	Formate acetyltransferase
HV319_RS03040	COG0251	oxidation-reduction process
HV319_RS03045	COG1760	l-serine dehydratase
HV319_RS03050	COG0814	amino acid
HV319_RS03065	COG1741	Belongs to the pirin family
HV319_RS03070	COG0583	DNA-binding transcription factor activity
HV319_RS03075	COG3152	Membrane
HV319_RS03080	COG0435	Glutathione S-transferase
HV319_RS03085	COG2259	Doxx family
HV319_RS03095	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV319_RS03100	COG4575	ribosome binding
HV319_RS03105	COG1422	Protein of unknown function (DUF1090)
HV319_RS03115	COG0586	Pfam SNARE associated Golgi protein
HV319_RS03120	COG2186	Transcriptional regulator
HV319_RS03125	COG2271	Major facilitator Superfamily
HV319_RS03135	COG2721	sulfolactate sulfo-lyase activity
HV319_RS03155	COG0673	inositol 2-dehydrogenase activity
HV319_RS03160	COG1451	nucleotide metabolic process
HV319_RS03170	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV319_RS03170	COG1902	pentaerythritol trinitrate reductase activity
HV319_RS03175	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HV319_RS03175	COG3408	Glycogen debranching enzyme
HV319_RS03185	COG0531	amino acid
HV319_RS03190	COG2731	YhcH YjgK YiaL family protein
HV319_RS03195	COG3250	beta-galactosidase activity
HV319_RS03200	COG1609	Transcriptional regulator
HV319_RS03205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV319_RS03215	COG0840	transmembrane signaling receptor activity
HV319_RS03220	COG1695	Transcriptional regulator
HV319_RS03225	COG2375	cellular response to nickel ion
HV319_RS03235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV319_RS03330	COG3391	amine dehydrogenase activity
HV319_RS03340	COG0358	DNA primase activity
HV319_RS03345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV319_RS03350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV319_RS03355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV319_RS03365	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV319_RS03395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS03400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS03415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV319_RS03430	COG4991	sh3 domain protein
HV319_RS03435	COG3025	triphosphatase activity
HV319_RS03450	COG2268	Band 7 protein
HV319_RS03455	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV319_RS03495	COG3384	dioxygenase
HV319_RS03500	COG0754	glutathionylspermidine amidase activity
HV319_RS03515	COG0494	nUDIX hydrolase
HV319_RS03520	COG3151	Protein conserved in bacteria
HV319_RS03525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV319_RS03530	COG3150	esterase
HV319_RS03535	COG0187	DNA topoisomerase II activity
HV319_RS03540	COG4977	sequence-specific DNA binding
HV319_RS03540	COG1917	Cupin 2, conserved barrel domain protein
HV319_RS03550	COG2211	Major facilitator Superfamily
HV319_RS03555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV319_RS03560	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV319_RS03565	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV319_RS03580	COG3111	PFAM Bacterial OB fold (BOF) protein
HV319_RS03615	COG0471	metal ion transport
HV319_RS03620	COG0656	L-ascorbic acid biosynthetic process
HV319_RS03625	COG1979	alcohol dehydrogenase
HV319_RS03630	COG2207	Transcriptional regulator
HV319_RS03635	COG0586	Pfam SNARE associated Golgi protein
HV319_RS03640	COG0626	cystathionine gamma-synthase activity
HV319_RS03650	COG0848	biopolymer transport protein
HV319_RS03670	COG0667	Aldo Keto reductase
HV319_RS03680	COG0840	transmembrane signaling receptor activity
HV319_RS03690	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV319_RS03695	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS03700	COG5557	Pfam Polysulphide reductase, NrfD
HV319_RS03705	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV319_RS03710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV319_RS03715	COG1773	rubredoxin
HV319_RS03725	COG0298	carbon dioxide binding
HV319_RS03730	COG0625	glutathione transferase activity
HV319_RS03735	COG0243	molybdopterin cofactor binding
HV319_RS03740	COG0754	glutathionylspermidine amidase activity
HV319_RS03775	COG2003	Belongs to the UPF0758 family
HV319_RS03800	COG2378	regulation of single-species biofilm formation
HV319_RS03810	COG3596	GTP binding
HV319_RS03855	COG1393	Belongs to the ArsC family
HV319_RS03860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV319_RS03915	COG3344	reverse transcriptase
HV319_RS03925	COG2826	transposase and inactivated derivatives, IS30 family
HV319_RS03945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HV319_RS03955	COG1136	(ABC) transporter
HV319_RS04010	COG0582	viral genome integration into host DNA
HV319_RS04020	COG1811	Na channel or pump
HV319_RS04025	COG1982	Orn Lys Arg decarboxylase major
HV319_RS04030	COG2211	Major facilitator Superfamily
HV319_RS04045	COG1194	a g-specific adenine glycosylase
HV319_RS04055	COG3171	Protein conserved in bacteria
HV319_RS04065	COG0252	asparaginase activity
HV319_RS04070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV319_RS04085	COG0762	integral membrane protein
HV319_RS04090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV319_RS04095	COG2805	Type II/IV secretion system protein
HV319_RS04110	COG0189	ligase activity
HV319_RS04115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV319_RS04120	COG2356	endonuclease I
HV319_RS04125	COG3091	SprT-like family
HV319_RS04130	COG2814	Major facilitator Superfamily
HV319_RS04150	COG1166	arginine decarboxylase activity
HV319_RS04160	COG0501	Belongs to the peptidase M48B family
HV319_RS04165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV319_RS04175	COG1122	ATPase activity
HV319_RS04205	COG0191	fructose-bisphosphate aldolase activity
HV319_RS04210	COG0668	transmembrane transport
HV319_RS04215	COG1279	arginine transmembrane transporter activity
HV319_RS04220	COG2968	Membrane
HV319_RS04225	COG0583	DNA-binding transcription factor activity
HV319_RS04230	COG0427	acetyl-CoA hydrolase
HV319_RS04235	COG1024	Enoyl-CoA hydratase
HV319_RS04240	COG1703	isobutyryl-CoA mutase activity
HV319_RS04245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV319_RS04245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV319_RS04260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV319_RS04265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV319_RS04285	COG0006	proline dipeptidase activity
HV319_RS04290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV319_RS04295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV319_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS04320	COG2723	6-phospho-beta-galactosidase activity
HV319_RS04325	COG1737	Transcriptional regulator
HV319_RS04335	COG1272	protein, Hemolysin III
HV319_RS04345	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV319_RS04370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV319_RS04390	COG4942	peptidase
HV319_RS04400	COG0582	viral genome integration into host DNA
HV319_RS04455	COG0842	Transport permease protein
HV319_RS04460	COG1129	ABC transporter
HV319_RS04460	COG0842	Transport permease protein
HV319_RS04465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS04515	COG3311	Transcriptional regulator
HV319_RS04525	COG4983	Phage plasmid primase, P4 family domain protein
HV319_RS04550	COG2003	Belongs to the UPF0758 family
HV319_RS04660	COG0457	Tetratricopeptide repeat
HV319_RS04665	COG1649	PFAM Uncharacterised BCR, COG1649
HV319_RS04665	COG0726	polysaccharide deacetylase
HV319_RS04670	COG1215	transferase activity, transferring glycosyl groups
HV319_RS04680	COG3592	Divergent 4Fe-4S mono-cluster
HV319_RS04685	COG2388	GCN5-related N-acetyl-transferase
HV319_RS04690	COG0583	DNA-binding transcription factor activity
HV319_RS04695	COG0666	response to abiotic stimulus
HV319_RS04705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV319_RS04710	COG1304	FMN binding
HV319_RS04720	COG0549	Belongs to the carbamate kinase family
HV319_RS04725	COG0402	S-adenosylhomocysteine deaminase activity
HV319_RS04740	COG0814	amino acid
HV319_RS04755	COG0183	Belongs to the thiolase family
HV319_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS04770	COG2814	Major facilitator Superfamily
HV319_RS04775	COG5464	transposase or invertase
HV319_RS04785	COG1794	racemase activity, acting on amino acids and derivatives
HV319_RS04790	COG0583	DNA-binding transcription factor activity
HV319_RS04800	COG1609	Transcriptional regulator
HV319_RS04820	COG0667	Aldo Keto reductase
HV319_RS04830	COG0861	Integral membrane protein TerC family
HV319_RS04860	COG2165	general secretion pathway protein
HV319_RS04865	COG4795	General secretion pathway protein
HV319_RS04875	COG4967	type IV pilus modification protein PilV
HV319_RS04880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV319_RS04890	COG1074	ATP-dependent DNA helicase activity
HV319_RS04895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV319_RS04900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV319_RS04900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV319_RS04905	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV319_RS04930	COG3121	Chaperone
HV319_RS04935	COG3188	usher protein
HV319_RS04970	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV319_RS04975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV319_RS04980	COG2166	iron-sulfur cluster assembly
HV319_RS04985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV319_RS04995	COG0583	DNA-binding transcription factor activity
HV319_RS05000	COG2363	Small membrane protein
HV319_RS05010	COG1349	DNA-binding transcription factor activity
HV319_RS05020	COG1070	Carbohydrate kinase
HV319_RS05030	COG1129	ABC transporter
HV319_RS05035	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV319_RS05045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV319_RS05055	COG0235	Class ii aldolase
HV319_RS05060	COG1454	alcohol dehydrogenase
HV319_RS05070	COG1760	l-serine dehydratase
HV319_RS05075	COG0814	amino acid
HV319_RS05080	COG1611	Belongs to the LOG family
HV319_RS05095	COG3098	single-species biofilm formation
HV319_RS05100	COG0564	pseudouridine synthase activity
HV319_RS05105	COG0716	FMN binding
HV319_RS05110	COG2271	Major facilitator Superfamily
HV319_RS05115	COG4948	Mandelate Racemase Muconate Lactonizing
HV319_RS05120	COG4948	Mandelate Racemase Muconate Lactonizing
HV319_RS05125	COG1929	Belongs to the glycerate kinase type-1 family
HV319_RS05130	COG4999	Histidine kinase
HV319_RS05130	COG3850	Histidine kinase
HV319_RS05130	COG3437	response regulator, receiver
HV319_RS05130	COG2205	protein histidine kinase activity
HV319_RS05140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV319_RS05145	COG3956	TIGRFAM MazG family protein
HV319_RS05160	COG1737	Transcriptional regulator
HV319_RS05165	COG1263	PTS System
HV319_RS05165	COG2190	(PTS) system
HV319_RS05165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS05170	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV319_RS05175	COG0602	queuosine metabolic process
HV319_RS05180	COG0720	synthase
HV319_RS05200	COG2234	aminopeptidase activity
HV319_RS05255	COG4942	peptidase
HV319_RS05255	COG1388	LysM domain
HV319_RS05270	COG0163	prenyltransferase activity
HV319_RS05275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV319_RS05295	COG0582	viral genome integration into host DNA
HV319_RS05360	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV319_RS05370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV319_RS05400	COG0628	permease
HV319_RS05405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV319_RS05425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV319_RS05430	COG1882	Formate acetyltransferase
HV319_RS05450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV319_RS05455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV319_RS05460	COG1121	(ABC) transporter
HV319_RS05485	COG0309	Hydrogenase expression formation protein (HypE)
HV319_RS05490	COG0409	Hydrogenase expression formation protein
HV319_RS05495	COG0298	carbon dioxide binding
HV319_RS05500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV319_RS05505	COG0375	protein maturation
HV319_RS05515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV319_RS05520	COG0651	ATP synthesis coupled electron transport
HV319_RS05525	COG0650	Formate hydrogenlyase subunit 4
HV319_RS05530	COG3261	NADH dehydrogenase
HV319_RS05530	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV319_RS05535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV319_RS05540	COG3260	NADH ubiquinone oxidoreductase 20
HV319_RS05550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV319_RS05560	COG2723	6-phospho-beta-galactosidase activity
HV319_RS05565	COG1263	PTS System
HV319_RS05565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS05570	COG1609	Transcriptional regulator
HV319_RS05575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV319_RS05580	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV319_RS05600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV319_RS05600	COG0517	IMP dehydrogenase activity
HV319_RS05605	COG1349	DNA-binding transcription factor activity
HV319_RS05610	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS05615	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS05625	COG3732	PTS system glucitol sorbitol-specific
HV319_RS05630	COG3730	PTS system glucitol sorbitol-specific
HV319_RS05635	COG2951	lytic endotransglycosylase activity
HV319_RS05640	COG1546	Belongs to the CinA family
HV319_RS05660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV319_RS05695	COG1238	metal cluster binding
HV319_RS05715	COG2814	Major facilitator Superfamily
HV319_RS05720	COG1566	PFAM secretion protein HlyD family protein
HV319_RS05725	COG1846	Transcriptional regulator
HV319_RS05735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV319_RS05740	COG2814	Major facilitator Superfamily
HV319_RS05750	COG4176	ABC-type proline glycine betaine transport system permease component
HV319_RS05780	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV319_RS05810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV319_RS05815	COG0640	Transcriptional regulator
HV319_RS05820	COG0401	homolog of Blt101
HV319_RS05825	COG1652	LysM domain
HV319_RS05830	COG1802	Transcriptional regulator
HV319_RS05835	COG1113	amino acid transport
HV319_RS05840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV319_RS05845	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS05850	COG0579	oxidoreductase
HV319_RS05860	COG1285	pathogenesis
HV319_RS05865	COG2211	Major facilitator Superfamily
HV319_RS05955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV319_RS05960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV319_RS05965	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV319_RS05970	COG2271	Major facilitator Superfamily
HV319_RS05975	COG2197	response regulator
HV319_RS06065	COG0582	viral genome integration into host DNA
HV319_RS06175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV319_RS06190	COG0582	viral genome integration into host DNA
HV319_RS06200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS06225	COG2867	negative regulation of translational initiation
HV319_RS06240	COG0497	DNA recombination
HV319_RS06255	COG4536	flavin adenine dinucleotide binding
HV319_RS06260	COG4137	Cytochrome C assembly protein
HV319_RS06265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV319_RS06290	COG2885	chlorophyll binding
HV319_RS06295	COG2199	diguanylate cyclase activity
HV319_RS06310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV319_RS06315	COG0287	Prephenate dehydrogenase
HV319_RS06315	COG1605	Chorismate mutase
HV319_RS06320	COG0077	Prephenate dehydratase
HV319_RS06320	COG1605	Chorismate mutase
HV319_RS06330	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV319_RS06335	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV319_RS06350	COG0542	response to heat
HV319_RS06375	COG0477	Major facilitator Superfamily
HV319_RS06380	COG5544	Lipoprotein
HV319_RS06385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV319_RS06400	COG3118	belongs to the thioredoxin family
HV319_RS06405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV319_RS06430	COG0513	Belongs to the DEAD box helicase family
HV319_RS06440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV319_RS06450	COG1595	DNA-templated transcription, initiation
HV319_RS06455	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV319_RS06460	COG3026	antisigma factor binding
HV319_RS06465	COG3086	response to oxidative stress
HV319_RS06475	COG0681	Belongs to the peptidase S26 family
HV319_RS06495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV319_RS06505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV319_RS06635	COG3179	chitinase
HV319_RS06785	COG2801	Transposase and inactivated derivatives
HV319_RS06795	COG1737	Transcriptional regulator
HV319_RS06800	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV319_RS06805	COG1263	PTS System
HV319_RS06805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS06810	COG0560	Phosphoserine phosphatase
HV319_RS06830	COG2205	protein histidine kinase activity
HV319_RS06835	COG3170	Tfp pilus assembly protein FimV
HV319_RS06840	COG2204	response regulator
HV319_RS06845	COG0347	Belongs to the P(II) protein family
HV319_RS06850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV319_RS06850	COG1017	nitric oxide dioxygenase activity
HV319_RS06880	COG4638	Rieske (2fe-2S)
HV319_RS06885	COG0583	DNA-binding transcription factor activity
HV319_RS06890	COG1940	carbohydrate kinase activity
HV319_RS06895	COG0457	Tetratricopeptide repeat
HV319_RS06900	COG2814	Major facilitator Superfamily
HV319_RS06900	COG0477	Major facilitator Superfamily
HV319_RS06910	COG2814	Major facilitator Superfamily
HV319_RS06915	COG3711	transcriptional antiterminator
HV319_RS06920	COG0517	IMP dehydrogenase activity
HV319_RS06920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV319_RS06925	COG1069	ribulokinase activity
HV319_RS06935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV319_RS06940	COG1129	ABC transporter
HV319_RS06950	COG3683	transport system, periplasmic component
HV319_RS06955	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV319_RS06960	COG1073	alpha beta
HV319_RS06980	COG1104	cysteine desulfurase activity
HV319_RS06985	COG0822	iron-sulfur transferase activity
HV319_RS07005	COG0633	Ferredoxin
HV319_RS07010	COG2975	iron-sulfur cluster assembly
HV319_RS07025	COG2897	thiosulfate sulfurtransferase activity
HV319_RS07030	COG2373	Large extracellular alpha-helical protein
HV319_RS07035	COG4953	penicillin-binding protein 1C
HV319_RS07050	COG1426	Protein conserved in bacteria
HV319_RS07065	COG2976	Protein conserved in bacteria
HV319_RS07080	COG3104	oligopeptide transport
HV319_RS07090	COG1645	bacterial-type flagellum-dependent swarming motility
HV319_RS07115	COG0517	IMP dehydrogenase activity
HV319_RS07115	COG0516	GMP reductase activity
HV319_RS07125	COG0668	transmembrane transport
HV319_RS07135	COG2200	EAL domain
HV319_RS07140	COG0248	Ppx GppA phosphatase
HV319_RS07150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV319_RS07160	COG2723	6-phospho-beta-galactosidase activity
HV319_RS07170	COG2233	PERMEase
HV319_RS07180	COG1393	Belongs to the ArsC family
HV319_RS07185	COG4783	chaperone-mediated protein folding
HV319_RS07190	COG0628	permease
HV319_RS07195	COG3366	ferrous iron transmembrane transporter activity
HV319_RS07200	COG0700	Nucleoside recognition
HV319_RS07205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV319_RS07210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV319_RS07215	COG2716	regulation of RNA biosynthetic process
HV319_RS07225	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV319_RS07235	COG2321	neutral zinc metallopeptidase
HV319_RS07245	COG0400	carboxylic ester hydrolase activity
HV319_RS07260	COG1393	Belongs to the ArsC family
HV319_RS07270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV319_RS07275	COG3850	Histidine kinase
HV319_RS07280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV319_RS07280	COG0493	'glutamate synthase
HV319_RS07290	COG5342	invasion associated locus B
HV319_RS07295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV319_RS07315	COG4766	ethanolamine catabolic process
HV319_RS07320	COG4812	Cobalamin adenosyltransferase
HV319_RS07380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HV319_RS07385	COG2207	Transcriptional regulator
HV319_RS07395	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV319_RS07415	COG2837	iron assimilation
HV319_RS07430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV319_RS07435	COG4208	sulfate ABC transporter
HV319_RS07440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV319_RS07505	COG3530	Putative quorum-sensing-regulated virulence factor
HV319_RS07510	COG0385	Bile acid
HV319_RS07515	COG0583	DNA-binding transcription factor activity
HV319_RS07525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV319_RS07530	COG2211	Major facilitator Superfamily
HV319_RS07535	COG0583	DNA-binding transcription factor activity
HV319_RS07565	COG3415	Transposase
HV319_RS07575	COG3415	Transposase
HV319_RS07590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV319_RS07605	COG0667	Aldo Keto reductase
HV319_RS07610	COG3961	Belongs to the TPP enzyme family
HV319_RS07625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS07630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS07640	COG1363	Peptidase, m42
HV319_RS07645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS07645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS07645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV319_RS07660	COG2207	Transcriptional regulator
HV319_RS07665	COG3279	Response regulator of the LytR AlgR family
HV319_RS07670	COG3275	phosphorelay sensor kinase activity
HV319_RS07675	COG0436	Aminotransferase
HV319_RS07690	COG1560	Kdo2-lipid A biosynthetic process
HV319_RS07720	COG3122	Protein conserved in bacteria
HV319_RS07725	COG0840	transmembrane signaling receptor activity
HV319_RS07740	COG2116	formate transmembrane transporter activity
HV319_RS07750	COG2067	long-chain fatty acid transport protein
HV319_RS07755	COG3691	Protein conserved in bacteria
HV319_RS07770	COG2062	phosphohistidine phosphatase, SixA
HV319_RS07795	COG0730	response to heat
HV319_RS07800	COG3101	peptidyl-lysine hydroxylation
HV319_RS07815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV319_RS07835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV319_RS07845	COG0586	Pfam SNARE associated Golgi protein
HV319_RS07855	COG0285	dihydrofolate synthase activity
HV319_RS07860	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV319_RS07865	COG1286	toxin biosynthetic process
HV319_RS07870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV319_RS07875	COG0163	prenyltransferase activity
HV319_RS07885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV319_RS07890	COG4215	(ABC) transporter
HV319_RS07900	COG4598	ABC transporter
HV319_RS07905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV319_RS07910	COG1090	epimerase
HV319_RS07915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV319_RS07920	COG0625	glutathione transferase activity
HV319_RS07925	COG0625	glutathione transferase activity
HV319_RS07930	COG0622	Phosphoesterase
HV319_RS07940	COG1288	antiporter activity
HV319_RS07965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV319_RS07970	COG0471	metal ion transport
HV319_RS07970	COG0490	domain, Protein
HV319_RS07980	COG0436	Aminotransferase
HV319_RS07985	COG0583	DNA-binding transcription factor activity
HV319_RS08005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV319_RS08030	COG0839	Belongs to the complex I subunit 6 family
HV319_RS08040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV319_RS08045	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV319_RS08055	COG0784	Response regulator, receiver
HV319_RS08055	COG0835	chemotaxis
HV319_RS08065	COG2153	protein acetylation
HV319_RS08070	COG4575	ribosome binding
HV319_RS08075	COG1169	isochorismate synthase
HV319_RS08165	COG0247	lactate metabolic process
HV319_RS08175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV319_RS08180	COG2271	Major facilitator Superfamily
HV319_RS08185	COG0584	glycerophosphoryl diester phosphodiesterase
HV319_RS08190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV319_RS08225	COG2198	Histidine kinase
HV319_RS08225	COG0642	Histidine kinase
HV319_RS08230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV319_RS08235	COG1477	protein flavinylation
HV319_RS08240	COG2169	Transcriptional regulator
HV319_RS08240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV319_RS08245	COG3145	DNA-N1-methyladenine dioxygenase activity
HV319_RS08250	COG4615	Cyclic peptide transporter
HV319_RS08255	COG2239	Acts as a magnesium transporter
HV319_RS08260	COG0659	secondary active sulfate transmembrane transporter activity
HV319_RS08275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV319_RS08275	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV319_RS08280	COG3062	negative regulation of establishment of protein localization
HV319_RS08290	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS08295	COG0348	domain, Protein
HV319_RS08300	COG3043	anaerobic respiration
HV319_RS08305	COG3005	denitrification pathway
HV319_RS08310	COG4133	protoheme IX ABC transporter activity
HV319_RS08320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV319_RS08325	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV319_RS08335	COG1138	Cytochrome C-type biogenesis protein
HV319_RS08340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV319_RS08345	COG4235	cytochrome complex assembly
HV319_RS08345	COG3088	subunit of a heme lyase
HV319_RS08350	COG2197	response regulator
HV319_RS08400	COG1061	Type III restriction enzyme res subunit
HV319_RS08405	COG1187	pseudouridine synthase activity
HV319_RS08410	COG2814	Major facilitator Superfamily
HV319_RS08420	COG4172	Belongs to the ABC transporter superfamily
HV319_RS08425	COG4239	(ABC) transporter, permease
HV319_RS08430	COG4174	ABC transporter (Permease)
HV319_RS08435	COG4166	transmembrane transport
HV319_RS08440	COG2200	EAL domain
HV319_RS08445	COG0791	NLP P60 protein
HV319_RS08450	COG0671	phosphoesterase, PA-phosphatase related
HV319_RS08455	COG0523	cobalamin synthesis protein
HV319_RS08460	COG0246	Mannitol dehydrogenase
HV319_RS08465	COG1312	Catalyzes the dehydration of D-mannonate
HV319_RS08470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV319_RS08475	COG3005	denitrification pathway
HV319_RS08485	COG3381	protein complex oligomerization
HV319_RS08510	COG1105	Belongs to the carbohydrate kinase PfkB family
HV319_RS08515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS08515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS08515	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV319_RS08520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV319_RS08530	COG0583	DNA-binding transcription factor activity
HV319_RS08535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS08540	COG2313	pseudouridylate synthase activity
HV319_RS08545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV319_RS08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS08550	COG1522	sequence-specific DNA binding
HV319_RS08560	COG2855	membrane
HV319_RS08565	COG0583	DNA-binding transcription factor activity
HV319_RS08570	COG0833	amino acid
HV319_RS08575	COG4771	TonB-dependent receptor
HV319_RS08580	COG2271	Major facilitator Superfamily
HV319_RS08585	COG0560	Phosphoserine phosphatase
HV319_RS08610	COG2311	Membrane
HV319_RS08625	COG1129	ABC transporter
HV319_RS08640	COG0493	'glutamate synthase
HV319_RS08650	COG2949	membrane
HV319_RS08660	COG1346	cytolysis
HV319_RS08675	COG2271	Major facilitator Superfamily
HV319_RS08690	COG0625	glutathione transferase activity
HV319_RS08695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV319_RS08700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV319_RS08715	COG0586	Pfam SNARE associated Golgi protein
HV319_RS08725	COG1686	Belongs to the peptidase S11 family
HV319_RS08730	COG0277	FAD linked oxidase domain protein
HV319_RS08735	COG1472	Belongs to the glycosyl hydrolase 3 family
HV319_RS08740	COG1732	Glycine betaine
HV319_RS08745	COG1174	glycine betaine transport
HV319_RS08750	COG1125	glycine betaine transport
HV319_RS08755	COG1174	glycine betaine transport
HV319_RS08765	COG0789	Transcriptional regulator
HV319_RS08770	COG3275	phosphorelay sensor kinase activity
HV319_RS08780	COG4807	Protein conserved in bacteria
HV319_RS08785	COG4808	Protein conserved in bacteria
HV319_RS08795	COG0489	protein tyrosine kinase activity
HV319_RS08810	COG3121	Chaperone
HV319_RS08825	COG3188	usher protein
HV319_RS08835	COG5455	response to cobalt ion
HV319_RS08845	COG0351	phosphomethylpyrimidine kinase
HV319_RS08850	COG2188	Transcriptional regulator
HV319_RS08860	COG1397	ADP-ribosylglycohydrolase
HV319_RS08865	COG2211	Major facilitator Superfamily
HV319_RS08870	COG1830	Aldolase
HV319_RS08880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV319_RS08885	COG4160	amino acid transport
HV319_RS08890	COG4215	(ABC) transporter
HV319_RS08895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV319_RS08900	COG1126	abc transporter atp-binding protein
HV319_RS08915	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV319_RS08920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV319_RS08925	COG0702	epimerase
HV319_RS08930	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV319_RS08935	COG0028	Belongs to the TPP enzyme family
HV319_RS08945	COG4529	Protein conserved in bacteria
HV319_RS08950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV319_RS08960	COG2431	L-lysine efflux transmembrane transporter activity
HV319_RS08970	COG3593	DNA synthesis involved in DNA repair
HV319_RS08975	COG2990	Protein conserved in bacteria
HV319_RS08980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS08990	COG1278	Cold shock
HV319_RS09000	COG0542	response to heat
HV319_RS09005	COG4974	Belongs to the 'phage' integrase family
HV319_RS09065	COG4695	Portal protein
HV319_RS09195	COG0745	RESPONSE REGULATOR receiver
HV319_RS09200	COG2205	protein histidine kinase activity
HV319_RS09230	COG0443	Heat shock 70 kDa protein
HV319_RS09235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV319_RS09240	COG3447	MASE1 domain protein
HV319_RS09240	COG5002	protein histidine kinase activity
HV319_RS09240	COG5001	Diguanylate cyclase
HV319_RS09255	COG2982	Protein involved in outer membrane biogenesis
HV319_RS09260	COG1253	flavin adenine dinucleotide binding
HV319_RS09280	COG0463	Glycosyl transferase, family 2
HV319_RS09285	COG1045	serine acetyltransferase
HV319_RS09290	COG0438	transferase activity, transferring glycosyl groups
HV319_RS09300	COG1216	Glycosyl transferase, family 2
HV319_RS09305	COG0110	maltose O-acetyltransferase activity
HV319_RS09310	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV319_RS09315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV319_RS09320	COG1051	belongs to the nudix hydrolase family
HV319_RS09325	COG0297	glycogen (starch) synthase activity
HV319_RS09335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV319_RS09340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV319_RS09345	COG2244	polysaccharide biosynthetic process
HV319_RS09350	COG2327	Polysaccharide pyruvyl transferase
HV319_RS09380	COG1215	transferase activity, transferring glycosyl groups
HV319_RS09385	COG0438	transferase activity, transferring glycosyl groups
HV319_RS09425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV319_RS09440	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV319_RS09445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HV319_RS09445	COG0140	phosphoribosyl-ATP diphosphatase activity
HV319_RS09460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV319_RS09490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV319_RS09495	COG0583	DNA-binding transcription factor activity
HV319_RS09505	COG0531	amino acid
HV319_RS09510	COG2925	Exonuclease
HV319_RS09540	COG1289	transmembrane transporter activity
HV319_RS09575	COG4656	Part of a membrane complex involved in electron transport
HV319_RS09580	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS09580	COG1454	alcohol dehydrogenase
HV319_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS09765	COG1376	ErfK ybiS ycfS ynhG family protein
HV319_RS09770	COG3842	ATPase activity
HV319_RS09775	COG1178	ABC-type Fe3 transport system permease component
HV319_RS09780	COG1840	ABC-type Fe3 transport system, periplasmic component
HV319_RS09800	COG2076	Multidrug Resistance protein
HV319_RS09805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV319_RS09810	COG1418	mRNA catabolic process
HV319_RS09815	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV319_RS09820	COG3727	T/G mismatch-specific endonuclease activity
HV319_RS09825	COG0697	spore germination
HV319_RS09830	COG2354	Protein conserved in bacteria
HV319_RS09835	COG5475	Uncharacterized small protein (DUF2158)
HV319_RS09895	COG2882	bacterial-type flagellum organization
HV319_RS09900	COG1157	protein secretion by the type III secretion system
HV319_RS09925	COG0425	Belongs to the sulfur carrier protein TusA family
HV319_RS09940	COG0366	Alpha amylase catalytic
HV319_RS09995	COG2197	response regulator
HV319_RS10005	COG2197	response regulator
HV319_RS10050	COG3621	Patatin-like phospholipase
HV319_RS10055	COG1305	Transglutaminase-like
HV319_RS10065	COG2608	mercury ion transmembrane transporter activity
HV319_RS10070	COG3012	SEC-C Motif Domain Protein
HV319_RS10070	COG3318	Belongs to the UPF0149 family
HV319_RS10075	COG0814	amino acid
HV319_RS10085	COG1528	Iron-storage protein
HV319_RS10100	COG0477	Major facilitator Superfamily
HV319_RS10110	COG1528	Iron-storage protein
HV319_RS10120	COG1879	ABC-type sugar transport system periplasmic component
HV319_RS10125	COG1129	ABC transporter
HV319_RS10130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV319_RS10145	COG0589	response to stress
HV319_RS10175	COG0835	chemotaxis
HV319_RS10185	COG1301	dicarboxylic acid transport
HV319_RS10195	COG0840	transmembrane signaling receptor activity
HV319_RS10210	COG0745	RESPONSE REGULATOR receiver
HV319_RS10250	COG3102	Protein conserved in bacteria
HV319_RS10270	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV319_RS10275	COG1801	Protein of unknown function DUF72
HV319_RS10285	COG2801	Transposase and inactivated derivatives
HV319_RS10390	COG4626	Terminase
HV319_RS10390	COG1802	Transcriptional regulator
HV319_RS10455	COG3042	response to heat
HV319_RS10460	COG3189	MarR family transcriptional regulator
HV319_RS10465	COG0504	CTP synthase activity
HV319_RS10470	COG2807	transmembrane transport
HV319_RS10475	COG2207	Transcriptional regulator
HV319_RS10485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV319_RS10490	COG2199	diguanylate cyclase activity
HV319_RS10495	COG2226	methyltransferase
HV319_RS10505	COG2766	serine protein kinase
HV319_RS10510	COG3713	MltA-interacting MipA family protein
HV319_RS10515	COG0656	L-ascorbic acid biosynthetic process
HV319_RS10535	COG3139	Protein of unknown function (DUF1315)
HV319_RS10550	COG1063	alcohol dehydrogenase
HV319_RS10555	COG2271	Major facilitator Superfamily
HV319_RS10560	COG1063	alcohol dehydrogenase
HV319_RS10565	COG0191	fructose-bisphosphate aldolase activity
HV319_RS10570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS10575	COG0667	Aldo Keto reductase
HV319_RS10580	COG1349	DNA-binding transcription factor activity
HV319_RS10585	COG2814	Major facilitator Superfamily
HV319_RS10590	COG1335	isochorismatase
HV319_RS10595	COG0252	asparaginase activity
HV319_RS10600	COG0616	signal peptide processing
HV319_RS10605	COG0778	Nitroreductase
HV319_RS10615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV319_RS10630	COG0494	nUDIX hydrolase
HV319_RS10635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV319_RS10640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV319_RS10645	COG2897	thiosulfate sulfurtransferase activity
HV319_RS10650	COG4136	ATPase activity
HV319_RS10655	COG4135	transport system, permease component
HV319_RS10660	COG4134	Bacterial extracellular solute-binding protein
HV319_RS10665	COG0398	Pfam SNARE associated Golgi protein
HV319_RS10670	COG0398	Pfam SNARE associated Golgi protein
HV319_RS10675	COG0708	Exodeoxyribonuclease III
HV319_RS10705	COG3678	ATP-independent chaperone mediated protein folding
HV319_RS10715	COG0322	excinuclease ABC activity
HV319_RS10725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV319_RS10730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV319_RS10735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV319_RS10740	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV319_RS10745	COG1917	Cupin 2, conserved barrel domain protein
HV319_RS10745	COG2169	Transcriptional regulator
HV319_RS10750	COG1486	melibiose metabolic process
HV319_RS10760	COG0753	catalase activity
HV319_RS10775	COG1988	membrane-bound metal-dependent
HV319_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS10785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV319_RS10795	COG3001	Fructosamine kinase
HV319_RS10800	COG1105	Belongs to the carbohydrate kinase PfkB family
HV319_RS10805	COG3137	Salt-induced outer membrane protein
HV319_RS10860	COG0463	Glycosyl transferase, family 2
HV319_RS10865	COG2246	polysaccharide biosynthetic process
HV319_RS10880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV319_RS10915	COG0386	Belongs to the glutathione peroxidase family
HV319_RS10925	COG0791	NLP P60 protein
HV319_RS10945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS10950	COG4558	Periplasmic binding protein
HV319_RS10955	COG3720	iron ion transport
HV319_RS10960	COG4771	TonB-dependent receptor
HV319_RS10965	COG4256	Hemin uptake protein
HV319_RS10970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV319_RS10980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV319_RS10980	COG0574	Belongs to the PEP-utilizing enzyme family
HV319_RS10985	COG0318	PFAM AMP-dependent synthetase and ligase
HV319_RS10990	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV319_RS10995	COG0644	oxidoreductase
HV319_RS11000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV319_RS11005	COG2086	electron transfer activity
HV319_RS11010	COG1917	Cupin 2, conserved barrel domain protein
HV319_RS11010	COG2207	Transcriptional regulator
HV319_RS11015	COG1960	acyl-CoA dehydrogenase activity
HV319_RS11020	COG4670	ketone body catabolic process
HV319_RS11035	COG2271	Major facilitator Superfamily
HV319_RS11040	COG0738	Major facilitator superfamily
HV319_RS11055	COG0628	permease
HV319_RS11060	COG0247	lactate metabolic process
HV319_RS11060	COG0277	FAD linked oxidase domain protein
HV319_RS11065	COG2050	protein possibly involved in aromatic compounds catabolism
HV319_RS11080	COG0583	DNA-binding transcription factor activity
HV319_RS11085	COG0316	Belongs to the HesB IscA family
HV319_RS11090	COG0719	Fe-S assembly protein
HV319_RS11095	COG0396	ATPase activity
HV319_RS11100	COG0719	Fe-S assembly protein
HV319_RS11115	COG1376	ErfK ybiS ycfS ynhG family protein
HV319_RS11130	COG0531	amino acid
HV319_RS11135	COG2267	carboxylic ester hydrolase activity
HV319_RS11145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS11155	COG2011	ABC-type metal ion transport system permease component
HV319_RS11160	COG1464	Belongs to the NlpA lipoprotein family
HV319_RS11195	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS11200	COG2414	aldehyde ferredoxin oxidoreductase
HV319_RS11210	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS11215	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV319_RS11225	COG0765	amino acid transport
HV319_RS11230	COG0765	amino acid transport
HV319_RS11240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV319_RS11250	COG1113	amino acid transport
HV319_RS11265	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS11275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV319_RS11290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV319_RS11335	COG4977	sequence-specific DNA binding
HV319_RS11350	COG3188	usher protein
HV319_RS11355	COG3121	Chaperone
HV319_RS11380	COG2378	regulation of single-species biofilm formation
HV319_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS11405	COG0628	permease
HV319_RS11410	COG0386	Belongs to the glutathione peroxidase family
HV319_RS11415	COG3300	MHYT domain
HV319_RS11415	COG5001	Diguanylate cyclase
HV319_RS11435	COG0251	oxidation-reduction process
HV319_RS11460	COG0307	riboflavin synthase, alpha
HV319_RS11465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV319_RS11470	COG2814	Major facilitator Superfamily
HV319_RS11475	COG0583	DNA-binding transcription factor activity
HV319_RS11490	COG2814	Major facilitator Superfamily
HV319_RS11495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV319_RS11500	COG0791	NLP P60 protein
HV319_RS11505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV319_RS11515	COG0346	lactoylglutathione lyase activity
HV319_RS11520	COG1902	pentaerythritol trinitrate reductase activity
HV319_RS11525	COG1309	transcriptional regulator
HV319_RS11530	COG3313	Fe-S protein
HV319_RS11535	COG4989	oxidoreductase activity
HV319_RS11540	COG2032	superoxide dismutase activity
HV319_RS11550	COG1566	PFAM secretion protein HlyD family protein
HV319_RS11575	COG3895	Periplasmic Protein
HV319_RS11590	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV319_RS11595	COG0625	glutathione transferase activity
HV319_RS11605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV319_RS11655	COG0673	inositol 2-dehydrogenase activity
HV319_RS11665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV319_RS11670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS11670	COG1263	PTS System
HV319_RS11675	COG1609	Transcriptional regulator
HV319_RS11680	COG5339	Protein conserved in bacteria
HV319_RS11690	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS11690	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS11705	COG2205	protein histidine kinase activity
HV319_RS11715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV319_RS11725	COG3039	Transposase
HV319_RS11730	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV319_RS11740	COG0745	RESPONSE REGULATOR receiver
HV319_RS11745	COG3136	membrane protein required for alginate biosynthesis
HV319_RS11755	COG0531	amino acid
HV319_RS11765	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV319_RS11770	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV319_RS11775	COG0628	permease
HV319_RS11795	COG3591	Belongs to the peptidase S1B family
HV319_RS11805	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV319_RS11820	COG0745	RESPONSE REGULATOR receiver
HV319_RS11825	COG5002	protein histidine kinase activity
HV319_RS11835	COG2814	Major facilitator Superfamily
HV319_RS11840	COG0583	DNA-binding transcription factor activity
HV319_RS11845	COG1940	carbohydrate kinase activity
HV319_RS11850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV319_RS11860	COG3381	protein complex oligomerization
HV319_RS11865	COG3302	dmso reductase anchor subunit
HV319_RS11870	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS11875	COG0243	molybdopterin cofactor binding
HV319_RS11890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV319_RS11905	COG4948	Mandelate Racemase Muconate Lactonizing
HV319_RS11925	COG0246	Mannitol dehydrogenase
HV319_RS11935	COG1802	Transcriptional regulator
HV319_RS11940	COG4221	oxidoreductase activity
HV319_RS11955	COG3706	GGDEF domain
HV319_RS11980	COG1129	ABC transporter
HV319_RS11985	COG0410	ABC transporter
HV319_RS11990	COG2814	Major facilitator Superfamily
HV319_RS12010	COG1846	Transcriptional regulator
HV319_RS12025	COG0583	DNA-binding transcription factor activity
HV319_RS12030	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS12060	COG3781	membrane
HV319_RS12085	COG2801	Transposase and inactivated derivatives
HV319_RS12095	COG2801	Transposase and inactivated derivatives
HV319_RS12105	COG2801	Transposase and inactivated derivatives
HV319_RS12115	COG2801	Transposase and inactivated derivatives
HV319_RS12125	COG3772	lysozyme
HV319_RS12215	COG1783	phage Terminase large subunit
HV319_RS12370	COG3121	Chaperone
HV319_RS12385	COG3121	Chaperone
HV319_RS12405	COG4628	conserved protein (DUF2132)
HV319_RS12430	COG0840	transmembrane signaling receptor activity
HV319_RS12445	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV319_RS12450	COG0747	negative chemotaxis
HV319_RS12455	COG0601	transmembrane transport
HV319_RS12460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV319_RS12465	COG0444	Belongs to the ABC transporter superfamily
HV319_RS12470	COG4608	Belongs to the ABC transporter superfamily
HV319_RS12480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV319_RS12485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV319_RS12495	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV319_RS12500	COG2610	gluconate transmembrane transporter activity
HV319_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS12510	COG1764	response to oxidative stress
HV319_RS12525	COG0488	(ABC) transporter
HV319_RS12530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HV319_RS12535	COG2864	formate dehydrogenase
HV319_RS12540	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS12550	COG0697	spore germination
HV319_RS12575	COG2223	nitrite transmembrane transporter activity
HV319_RS12580	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV319_RS12585	COG1140	nitrate reductase beta subunit
HV319_RS12590	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV319_RS12595	COG2181	nitrate reductase activity
HV319_RS12600	COG0384	phenazine biosynthesis protein PhzF
HV319_RS12615	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV319_RS12620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV319_RS12640	COG0625	glutathione transferase activity
HV319_RS12645	COG0583	DNA-binding transcription factor activity
HV319_RS12650	COG3321	synthase
HV319_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS12650	COG0604	alcohol dehydrogenase
HV319_RS12655	COG1126	abc transporter atp-binding protein
HV319_RS12675	COG1473	amidohydrolase
HV319_RS12680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV319_RS12685	COG0840	transmembrane signaling receptor activity
HV319_RS12705	COG2130	NADP-dependent
HV319_RS12715	COG1247	-acetyltransferase
HV319_RS12720	COG3238	Protein conserved in bacteria
HV319_RS12730	COG0747	negative chemotaxis
HV319_RS12770	COG1177	transmembrane transport
HV319_RS12775	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV319_RS12780	COG3842	ATPase activity
HV319_RS12785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV319_RS12790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV319_RS12800	COG1271	oxidase subunit
HV319_RS12805	COG1294	oxidase, subunit
HV319_RS12820	COG0826	peptidase U32
HV319_RS12825	COG1396	sequence-specific DNA binding
HV319_RS12830	COG3135	benzoate transporter
HV319_RS12840	COG0697	spore germination
HV319_RS12850	COG0500	methyltransferase
HV319_RS12855	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV319_RS12860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV319_RS12865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV319_RS12875	COG2841	Protein conserved in bacteria
HV319_RS12885	COG5383	Protein conserved in bacteria
HV319_RS12890	COG1227	inorganic diphosphatase activity
HV319_RS12895	COG0583	DNA-binding transcription factor activity
HV319_RS12905	COG3121	Chaperone
HV319_RS12910	COG3188	usher protein
HV319_RS12930	COG0840	transmembrane signaling receptor activity
HV319_RS12950	COG3059	membrane
HV319_RS12960	COG0243	molybdopterin cofactor binding
HV319_RS12960	COG3383	formate dehydrogenase (NAD+) activity
HV319_RS12965	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS12970	COG2864	formate dehydrogenase
HV319_RS13005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV319_RS13065	COG3038	cytochrome b561
HV319_RS13070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV319_RS13075	COG2755	lipolytic protein G-D-S-L family
HV319_RS13075	COG0657	acetylesterase activity
HV319_RS13080	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS13085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV319_RS13090	COG1643	Atp-dependent helicase
HV319_RS13100	COG3784	Protein of unknown function (DUF1318)
HV319_RS13110	COG2911	Protein conserved in bacteria
HV319_RS13115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV319_RS13120	COG3187	Heat shock protein
HV319_RS13125	COG3042	response to heat
HV319_RS13130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV319_RS13130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV319_RS13130	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV319_RS13130	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV319_RS13135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV319_RS13145	COG0589	response to stress
HV319_RS13155	COG0513	Belongs to the DEAD box helicase family
HV319_RS13195	COG3706	GGDEF domain
HV319_RS13230	COG3182	Iron-regulated membrane protein
HV319_RS13235	COG0668	transmembrane transport
HV319_RS13245	COG0346	lactoylglutathione lyase activity
HV319_RS13250	COG1349	DNA-binding transcription factor activity
HV319_RS13270	COG4166	transmembrane transport
HV319_RS13275	COG2866	Carboxypeptidase
HV319_RS13280	COG4948	Mandelate Racemase Muconate Lactonizing
HV319_RS13285	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV319_RS13300	COG3106	COG3106 Predicted ATPase
HV319_RS13305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV319_RS13310	COG1609	Transcriptional regulator
HV319_RS13325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV319_RS13330	COG1554	hydrolase, family 65, central catalytic
HV319_RS13335	COG0673	inositol 2-dehydrogenase activity
HV319_RS13340	COG1082	Xylose isomerase domain protein TIM barrel
HV319_RS13345	COG1063	alcohol dehydrogenase
HV319_RS13350	COG0395	ABC-type sugar transport system, permease component
HV319_RS13355	COG1175	transmembrane transport
HV319_RS13360	COG1653	transport
HV319_RS13365	COG0366	Alpha amylase catalytic
HV319_RS13375	COG1983	PspC domain protein
HV319_RS13385	COG1842	Phage shock protein A
HV319_RS13390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV319_RS13415	COG4171	peptide transport system, permease
HV319_RS13435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV319_RS13440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV319_RS13440	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV319_RS13450	COG5001	Diguanylate cyclase
HV319_RS13460	COG1349	DNA-binding transcription factor activity
HV319_RS13470	COG0023	Translation Initiation Factor
HV319_RS13480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV319_RS13485	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV319_RS13490	COG0671	phosphoesterase, PA-phosphatase related
HV319_RS13500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV319_RS13515	COG0583	DNA-binding transcription factor activity
HV319_RS13530	COG0616	signal peptide processing
HV319_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS13545	COG1187	pseudouridine synthase activity
HV319_RS13630	COG0009	L-threonylcarbamoyladenylate synthase
HV319_RS13685	COG0217	transcriptional regulatory protein
HV319_RS13690	COG3047	cAMP biosynthetic process
HV319_RS13715	COG2350	Protein conserved in bacteria
HV319_RS13735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV319_RS13745	COG0444	Belongs to the ABC transporter superfamily
HV319_RS13765	COG2095	MarC family integral membrane protein
HV319_RS13770	COG1454	alcohol dehydrogenase
HV319_RS13770	COG1012	belongs to the aldehyde dehydrogenase family
HV319_RS13775	COG1435	thymidine kinase activity
HV319_RS13785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV319_RS13790	COG0745	RESPONSE REGULATOR receiver
HV319_RS13795	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV319_RS13805	COG0788	formyltetrahydrofolate deformylase activity
HV319_RS13830	COG2181	nitrate reductase activity
HV319_RS13835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV319_RS13840	COG1140	nitrate reductase beta subunit
HV319_RS13845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV319_RS13850	COG2223	nitrite transmembrane transporter activity
HV319_RS13855	COG3850	Histidine kinase
HV319_RS13860	COG2197	response regulator
HV319_RS13865	COG4932	domain protein
HV319_RS13870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV319_RS13880	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV319_RS13885	COG0387	Pfam Sodium calcium exchanger
HV319_RS13900	COG3094	Invasion gene expression up-regulator, SirB
HV319_RS13905	COG2890	protein-(glutamine-N5) methyltransferase activity
HV319_RS13935	COG0659	secondary active sulfate transmembrane transporter activity
HV319_RS13940	COG0076	glutamate decarboxylase activity
HV319_RS13945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV319_RS13950	COG0527	aspartate kinase activity
HV319_RS13965	COG0012	GTP binding
HV319_RS14010	COG2200	EAL domain
HV319_RS14015	COG0789	Transcriptional regulator
HV319_RS14040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV319_RS14045	COG2376	Dihydroxyacetone kinase
HV319_RS14050	COG1461	Dihydroxyacetone kinase
HV319_RS14075	COG1120	ATPase activity
HV319_RS14080	COG0500	methyltransferase
HV319_RS14085	COG0157	Belongs to the NadC ModD family
HV319_RS14110	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV319_RS14120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV319_RS14160	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV319_RS14175	COG2894	cell division
HV319_RS14185	COG0583	DNA-binding transcription factor activity
HV319_RS14190	COG0473	3-isopropylmalate dehydrogenase activity
HV319_RS14195	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV319_RS14200	COG0318	PFAM AMP-dependent synthetase and ligase
HV319_RS14205	COG3065	identical protein binding
HV319_RS14210	COG1214	PFAM Peptidase M22, glycoprotease
HV319_RS14215	COG1199	ATP-dependent helicase activity
HV319_RS14220	COG0251	oxidation-reduction process
HV319_RS14240	COG1760	l-serine dehydratase
HV319_RS14245	COG2200	EAL domain
HV319_RS14250	COG1253	flavin adenine dinucleotide binding
HV319_RS14255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS14255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS14260	COG3715	PTS system
HV319_RS14265	COG3716	PTS system mannose fructose sorbose family IID component
HV319_RS14280	COG2226	methyltransferase
HV319_RS14285	COG0768	penicillin binding
HV319_RS14315	COG1414	Transcriptional regulator
HV319_RS14320	COG2814	Major facilitator Superfamily
HV319_RS14335	COG2197	response regulator
HV319_RS14500	COG1956	GAF domain-containing protein
HV319_RS14505	COG2995	paraquat-inducible protein a
HV319_RS14510	COG3008	intermembrane lipid transfer
HV319_RS14530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV319_RS14570	COG0740	serine-type endopeptidase activity
HV319_RS14620	COG3772	lysozyme
HV319_RS14635	COG1278	Cold shock
HV319_RS14680	COG0582	viral genome integration into host DNA
HV319_RS14690	COG1276	copper resistance
HV319_RS14695	COG2372	response to copper ion
HV319_RS14705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV319_RS14710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV319_RS14715	COG1770	oligopeptidase
HV319_RS14720	COG2979	Protein of unknown function (DUF533)
HV319_RS14730	COG3141	response to X-ray
HV319_RS14740	COG0800	Aldolase
HV319_RS14745	COG0129	dihydroxy-acid dehydratase activity
HV319_RS14750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV319_RS14755	COG1737	Transcriptional regulator
HV319_RS14765	COG1560	Kdo2-lipid A biosynthetic process
HV319_RS14770	COG0739	heme binding
HV319_RS14775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV319_RS14785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV319_RS14810	COG0494	nUDIX hydrolase
HV319_RS14820	COG1335	isochorismatase
HV319_RS14945	COG0740	serine-type endopeptidase activity
HV319_RS14985	COG1595	DNA-templated transcription, initiation
HV319_RS14990	COG3712	iron ion homeostasis
HV319_RS14995	COG4772	TonB-dependent receptor
HV319_RS15000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV319_RS15005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS15010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS15015	COG1120	ATPase activity
HV319_RS15040	COG0477	Major facilitator Superfamily
HV319_RS15045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV319_RS15060	COG0084	hydrolase, TatD family'
HV319_RS15065	COG0470	DNA polymerase III
HV319_RS15075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV319_RS15080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV319_RS15085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV319_RS15120	COG1399	metal-binding, possibly nucleic acid-binding protein
HV319_RS15130	COG0564	pseudouridine synthase activity
HV319_RS15135	COG1530	ribonuclease E activity
HV319_RS15140	COG0583	DNA-binding transcription factor activity
HV319_RS15145	COG2814	Major facilitator Superfamily
HV319_RS15175	COG4786	Flagellar basal body rod
HV319_RS15180	COG4787	bacterial-type flagellum-dependent cell motility
HV319_RS15195	COG1558	bacterial-type flagellum-dependent cell motility
HV319_RS15235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV319_RS15275	COG3038	cytochrome b561
HV319_RS15290	COG1560	Kdo2-lipid A biosynthetic process
HV319_RS15300	COG2199	diguanylate cyclase activity
HV319_RS15310	COG5645	(Lipo)protein
HV319_RS15330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV319_RS15385	COG3381	protein complex oligomerization
HV319_RS15410	COG2962	Rard protein
HV319_RS15415	COG2990	Protein conserved in bacteria
HV319_RS15420	COG1702	phosphate starvation-inducible protein PhoH
HV319_RS15445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV319_RS15450	COG0506	proline dehydrogenase activity
HV319_RS15450	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV319_RS15450	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV319_RS15455	COG3755	Protein conserved in bacteria
HV319_RS15460	COG1309	transcriptional regulator
HV319_RS15470	COG3729	General stress protein
HV319_RS15490	COG0640	Transcriptional regulator
HV319_RS15510	COG0577	efflux transmembrane transporter activity
HV319_RS15510	COG1136	(ABC) transporter
HV319_RS15520	COG0577	efflux transmembrane transporter activity
HV319_RS15520	COG1136	(ABC) transporter
HV319_RS15535	COG0672	)-iron permease
HV319_RS15540	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV319_RS15545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV319_RS15550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV319_RS15550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV319_RS15595	COG3039	Transposase
HV319_RS15605	COG0813	purine-nucleoside phosphorylase activity
HV319_RS15620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS15625	COG1120	ATPase activity
HV319_RS15635	COG0723	plastoquinol--plastocyanin reductase activity
HV319_RS15640	COG2857	Cytochrome c1
HV319_RS15640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV319_RS15660	COG0670	Belongs to the BI1 family
HV319_RS15685	COG1832	CoA-binding protein
HV319_RS15700	COG0210	DNA helicase
HV319_RS15705	COG3304	Inner membrane component domain
HV319_RS15710	COG1289	transmembrane transporter activity
HV319_RS15715	COG3070	regulator of competence-specific genes
HV319_RS15735	COG1067	ATP-dependent peptidase activity
HV319_RS15745	COG3130	regulation of translation
HV319_RS15750	COG3009	Protein conserved in bacteria
HV319_RS15755	COG3008	intermembrane lipid transfer
HV319_RS15755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV319_RS15760	COG2995	paraquat-inducible protein a
HV319_RS15765	COG0488	(ABC) transporter
HV319_RS15775	COG3217	Mosc domain protein beta barrel domain protein
HV319_RS15775	COG0633	Ferredoxin
HV319_RS15790	COG0431	NADPH-dependent FMN reductase
HV319_RS15795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV319_RS15805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV319_RS15810	COG1116	anion transmembrane transporter activity
HV319_RS15815	COG0308	aminopeptidase N
HV319_RS15835	COG1448	Aminotransferase
HV319_RS15840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV319_RS15845	COG3108	Peptidase M15
HV319_RS15850	COG2989	Protein conserved in bacteria
HV319_RS15860	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV319_RS15870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV319_RS15875	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV319_RS15880	COG3173	Aminoglycoside phosphotransferase
HV319_RS15895	COG3214	Protein conserved in bacteria
HV319_RS15910	COG0658	competence protein
HV319_RS15910	COG2333	competence protein COMEC
HV319_RS15915	COG0776	regulation of translation
HV319_RS15920	COG0539	negative regulation of cytoplasmic translation
HV319_RS15940	COG2323	membrane
HV319_RS15945	COG1944	ATP diphosphatase activity
HV319_RS15950	COG2116	formate transmembrane transporter activity
HV319_RS15955	COG1882	Formate acetyltransferase
HV319_RS15960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV319_RS15965	COG0531	amino acid
HV319_RS15985	COG1335	isochorismatase
HV319_RS15990	COG3302	dmso reductase anchor subunit
HV319_RS15995	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS16000	COG0243	molybdopterin cofactor binding
HV319_RS16010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV319_RS16020	COG1178	ABC-type Fe3 transport system permease component
HV319_RS16020	COG1674	ftsk spoiiie
HV319_RS16030	COG0492	ferredoxin-NADP+ reductase activity
HV319_RS16035	COG4988	ABC transporter
HV319_RS16040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV319_RS16055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV319_RS16060	COG0583	DNA-binding transcription factor activity
HV319_RS16070	COG1335	isochorismatase
HV319_RS16090	COG1177	transmembrane transport
HV319_RS16095	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV319_RS16100	COG3842	ATPase activity
HV319_RS16105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV319_RS16165	COG0583	DNA-binding transcription factor activity
HV319_RS16170	COG3226	Transcriptional regulator
HV319_RS16175	COG0738	Major facilitator superfamily
HV319_RS16180	COG0561	phosphatase activity
HV319_RS16190	COG2814	Major facilitator Superfamily
HV319_RS16195	COG0671	phosphoesterase, PA-phosphatase related
HV319_RS16200	COG1349	DNA-binding transcription factor activity
HV319_RS16205	COG1686	Belongs to the peptidase S11 family
HV319_RS16210	COG0625	glutathione transferase activity
HV319_RS16215	COG2133	pyrroloquinoline quinone binding
HV319_RS16350	COG1446	asparaginase
HV319_RS16360	COG0303	'Molybdopterin
HV319_RS16365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV319_RS16370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV319_RS16375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV319_RS16380	COG1882	Formate acetyltransferase
HV319_RS16385	COG0561	phosphatase activity
HV319_RS16395	COG0488	(ABC) transporter
HV319_RS16400	COG1376	ErfK ybiS ycfS ynhG family protein
HV319_RS16405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV319_RS16420	COG2194	sulfuric ester hydrolase activity
HV319_RS16425	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV319_RS16440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV319_RS16445	COG0765	amino acid transport
HV319_RS16450	COG1126	abc transporter atp-binding protein
HV319_RS16455	COG0668	transmembrane transport
HV319_RS16470	COG4774	siderophore transport
HV319_RS16480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV319_RS16490	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV319_RS16495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV319_RS16505	COG0471	metal ion transport
HV319_RS16515	COG2188	Transcriptional regulator
HV319_RS16520	COG0513	Belongs to the DEAD box helicase family
HV319_RS16525	COG1309	transcriptional regulator
HV319_RS16535	COG1131	(ABC) transporter
HV319_RS16540	COG0842	Transport permease protein
HV319_RS16545	COG0842	Transport permease protein
HV319_RS16555	COG3568	Endonuclease Exonuclease Phosphatase
HV319_RS16560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV319_RS16565	COG0392	lysyltransferase activity
HV319_RS16570	COG0670	Belongs to the BI1 family
HV319_RS16575	COG0314	molybdopterin synthase activity
HV319_RS16580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV319_RS16590	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV319_RS16615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV319_RS16635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV319_RS16640	COG1881	PFAM PEBP family protein
HV319_RS16670	COG4677	pectinesterase activity
HV319_RS16695	COG0561	phosphatase activity
HV319_RS16705	COG4149	molybdate abc transporter
HV319_RS16710	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV319_RS16720	COG2005	Transcriptional regulator
HV319_RS16720	COG3585	molybdate ion transport
HV319_RS16725	COG1119	ATPase activity
HV319_RS16730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV319_RS16735	COG1085	galactose-1-phosphate uridylyltransferase
HV319_RS16745	COG2017	converts alpha-aldose to the beta-anomer
HV319_RS16755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV319_RS16765	COG1230	cation diffusion facilitator family transporter
HV319_RS16770	COG3201	nicotinamide mononucleotide transporter
HV319_RS16810	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV319_RS16815	COG2885	chlorophyll binding
HV319_RS16825	COG3064	Membrane
HV319_RS16830	COG0848	biopolymer transport protein
HV319_RS16835	COG0811	peptide transport
HV319_RS16840	COG0824	Thioesterase
HV319_RS16845	COG3790	cyd operon protein YbgE
HV319_RS16850	COG4890	Cyd operon protein YbgT
HV319_RS16855	COG1294	oxidase, subunit
HV319_RS16860	COG1271	oxidase subunit
HV319_RS16865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV319_RS16875	COG4865	methylaspartate mutase activity
HV319_RS16880	COG3799	methylaspartate ammonia-lyase activity
HV319_RS16895	COG1301	dicarboxylic acid transport
HV319_RS16905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS16905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS16915	COG0583	DNA-binding transcription factor activity
HV319_RS16920	COG1648	precorrin-2 dehydrogenase activity
HV319_RS16920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV319_RS16930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV319_RS16940	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV319_RS16945	COG0567	Dehydrogenase, E1 component
HV319_RS16950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV319_RS16955	COG1053	succinate dehydrogenase
HV319_RS16960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV319_RS16965	COG2009	succinate dehydrogenase
HV319_RS16975	COG3157	Type VI secretion system effector, Hcp
HV319_RS16990	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HV319_RS16995	COG3180	Ammonia monooxygenase
HV319_RS17025	COG1984	allophanate hydrolase subunit 2
HV319_RS17030	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV319_RS17045	COG5464	transposase or invertase
HV319_RS17055	COG3272	Protein of unknown function (DUF1722)
HV319_RS17085	COG2205	protein histidine kinase activity
HV319_RS17090	COG0745	RESPONSE REGULATOR receiver
HV319_RS17095	COG0033	Phosphoglucomutase
HV319_RS17100	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV319_RS17105	COG0596	Alpha beta hydrolase
HV319_RS17115	COG0716	FMN binding
HV319_RS17125	COG0735	belongs to the Fur family
HV319_RS17130	COG0583	DNA-binding transcription factor activity
HV319_RS17135	COG1053	succinate dehydrogenase
HV319_RS17165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS17165	COG1263	PTS System
HV319_RS17165	COG2190	(PTS) system
HV319_RS17175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV319_RS17180	COG1940	carbohydrate kinase activity
HV319_RS17180	COG1846	Transcriptional regulator
HV319_RS17185	COG0647	UMP catabolic process
HV319_RS17190	COG0367	asparagine synthase
HV319_RS17235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV319_RS17245	COG1702	phosphate starvation-inducible protein PhoH
HV319_RS17255	COG4535	Mg2 and Co2 transporter CorC
HV319_RS17270	COG0765	amino acid transport
HV319_RS17275	COG0765	amino acid transport
HV319_RS17280	COG1126	abc transporter atp-binding protein
HV319_RS17290	COG2888	peptidyl-tyrosine sulfation
HV319_RS17305	COG1466	dna polymerase III delta subunit
HV319_RS17315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV319_RS17325	COG0799	negative regulation of ribosome biogenesis
HV319_RS17335	COG0768	penicillin binding
HV319_RS17340	COG0772	Belongs to the SEDS family
HV319_RS17345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV319_RS17350	COG1686	Belongs to the peptidase S11 family
HV319_RS17375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV319_RS17400	COG3069	C4-dicarboxylate transmembrane transporter activity
HV319_RS17405	COG4565	transcriptional regulatory protein
HV319_RS17410	COG3290	protein histidine kinase activity
HV319_RS17415	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV319_RS17425	COG2301	Belongs to the HpcH HpaI aldolase family
HV319_RS17430	COG3051	citrate lyase alpha subunit
HV319_RS17445	COG0471	metal ion transport
HV319_RS17450	COG3719	Belongs to the RNase T2 family
HV319_RS17465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV319_RS17485	COG0243	molybdopterin cofactor binding
HV319_RS17495	COG3634	alkyl hydroperoxide reductase activity
HV319_RS17505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV319_RS17510	COG0583	DNA-binding transcription factor activity
HV319_RS17515	COG3969	phosphoadenosine phosphosulfate
HV319_RS17520	COG1475	DNA binding
HV319_RS17525	COG0436	Aminotransferase
HV319_RS17530	COG0371	Dehydrogenase
HV319_RS17535	COG2879	small protein
HV319_RS17540	COG1966	Carbon starvation protein
HV319_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS17555	COG1535	isochorismatase
HV319_RS17555	COG3433	isochorismatase activity
HV319_RS17560	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV319_RS17565	COG1169	isochorismate synthase
HV319_RS17570	COG4592	Periplasmic binding protein
HV319_RS17580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS17585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS17590	COG1120	ATPase activity
HV319_RS17595	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV319_RS17600	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV319_RS17600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV319_RS17605	COG3251	PFAM MbtH domain protein
HV319_RS17610	COG2382	esterase
HV319_RS17615	COG4771	TonB-dependent receptor
HV319_RS17655	COG2315	Protein conserved in bacteria
HV319_RS17665	COG0668	transmembrane transport
HV319_RS17685	COG2211	Major facilitator Superfamily
HV319_RS17690	COG1113	amino acid transport
HV319_RS17715	COG3300	MHYT domain
HV319_RS17715	COG5001	Diguanylate cyclase
HV319_RS17740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV319_RS17745	COG2207	Transcriptional regulator
HV319_RS17750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV319_RS17755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS17760	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS17765	COG1538	Outer membrane efflux protein
HV319_RS17770	COG0745	RESPONSE REGULATOR receiver
HV319_RS17775	COG5002	protein histidine kinase activity
HV319_RS17790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV319_RS17790	COG0321	lipoyl(octanoyl) transferase activity
HV319_RS17795	COG0243	molybdopterin cofactor binding
HV319_RS17800	COG3005	denitrification pathway
HV319_RS17835	COG0745	RESPONSE REGULATOR receiver
HV319_RS17840	COG1879	ABC-type sugar transport system periplasmic component
HV319_RS17845	COG0784	Response regulator, receiver
HV319_RS17845	COG2205	protein histidine kinase activity
HV319_RS17845	COG2198	Histidine kinase
HV319_RS17920	COG2501	S4 domain
HV319_RS17925	COG1988	membrane-bound metal-dependent
HV319_RS17935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV319_RS17945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV319_RS17950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV319_RS17955	COG0549	Belongs to the carbamate kinase family
HV319_RS17965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV319_RS17980	COG2084	Dehydrogenase
HV319_RS17985	COG3622	Belongs to the hyi family
HV319_RS17990	COG3960	tartronate-semialdehyde synthase activity
HV319_RS18025	COG1464	Belongs to the NlpA lipoprotein family
HV319_RS18030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV319_RS18035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV319_RS18040	COG4181	ATPase activity
HV319_RS18045	COG2755	lipolytic protein G-D-S-L family
HV319_RS18050	COG0300	oxidoreductase activity
HV319_RS18055	COG3118	belongs to the thioredoxin family
HV319_RS18060	COG0390	transport system, permease component
HV319_RS18065	COG4619	ABC transporter
HV319_RS18070	COG0330	HflC and HflK could
HV319_RS18075	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV319_RS18095	COG4771	TonB-dependent receptor
HV319_RS18100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV319_RS18110	COG3721	Heme iron utilization protein
HV319_RS18120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS18135	COG3735	TraB family
HV319_RS18140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV319_RS18150	COG2223	nitrite transmembrane transporter activity
HV319_RS18155	COG4651	solute:proton antiporter activity
HV319_RS18155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV319_RS18160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS18205	COG2832	Protein of unknown function (DUF454)
HV319_RS18210	COG3923	Primosomal replication protein n
HV319_RS18220	COG1196	nuclear chromosome segregation
HV319_RS18220	COG3264	Mechanosensitive ion channel
HV319_RS18225	COG1309	transcriptional regulator
HV319_RS18230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV319_RS18235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV319_RS18250	COG0110	maltose O-acetyltransferase activity
HV319_RS18270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV319_RS18275	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV319_RS18280	COG2364	Membrane
HV319_RS18285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV319_RS18305	COG3695	enzyme binding
HV319_RS18310	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV319_RS18315	COG1946	Acyl-CoA thioesterase
HV319_RS18320	COG0004	ammonium transporteR
HV319_RS18325	COG0347	Belongs to the P(II) protein family
HV319_RS18330	COG1132	(ABC) transporter
HV319_RS18335	COG1132	(ABC) transporter
HV319_RS18340	COG1522	sequence-specific DNA binding
HV319_RS18355	COG4533	DNA binding
HV319_RS18365	COG0824	Thioesterase
HV319_RS18370	COG1555	photosystem II stabilization
HV319_RS18375	COG4974	Belongs to the 'phage' integrase family
HV319_RS18455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV319_RS18460	COG0776	regulation of translation
HV319_RS18465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV319_RS18485	COG0271	Belongs to the BolA IbaG family
HV319_RS18490	COG3056	Lipoprotein
HV319_RS18495	COG2223	nitrite transmembrane transporter activity
HV319_RS18500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV319_RS18505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV319_RS18510	COG1845	cytochrome c oxidase, subunit III
HV319_RS18515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV319_RS18525	COG2814	Major facilitator Superfamily
HV319_RS18560	COG0142	geranyltranstransferase activity
HV319_RS18570	COG0667	Aldo Keto reductase
HV319_RS18575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV319_RS18580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV319_RS18595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV319_RS18595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV319_RS18605	COG4238	major outer membrane lipoprotein
HV319_RS18625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV319_RS18630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV319_RS18635	COG1862	Preprotein translocase
HV319_RS18645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV319_RS18655	COG0450	alkyl hydroperoxide reductase
HV319_RS18660	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV319_RS18670	COG1335	isochorismatase
HV319_RS18675	COG0583	DNA-binding transcription factor activity
HV319_RS18680	COG0366	Alpha amylase catalytic
HV319_RS18695	COG5002	protein histidine kinase activity
HV319_RS18705	COG0420	3'-5' exonuclease activity
HV319_RS18710	COG0419	ATPase involved in DNA repair
HV319_RS18715	COG2814	Major facilitator Superfamily
HV319_RS18720	COG1940	carbohydrate kinase activity
HV319_RS18735	COG4126	flavin adenine dinucleotide binding
HV319_RS18755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV319_RS18760	COG3706	GGDEF domain
HV319_RS18770	COG1785	Belongs to the alkaline phosphatase family
HV319_RS18785	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV319_RS18805	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV319_RS18810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV319_RS18815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV319_RS18825	COG0113	porphobilinogen synthase activity
HV319_RS18830	COG2175	clavaminate synthase activity
HV319_RS18835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV319_RS18840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV319_RS18845	COG4521	taurine ABC transporter
HV319_RS18860	COG2271	Major facilitator Superfamily
HV319_RS18865	COG1840	ABC-type Fe3 transport system, periplasmic component
HV319_RS18875	COG3842	ATPase activity
HV319_RS18880	COG2040	homocysteine
HV319_RS18885	COG0833	amino acid
HV319_RS18890	COG2814	Major facilitator Superfamily
HV319_RS18925	COG1414	Transcriptional regulator
HV319_RS18955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV319_RS18970	COG1609	Transcriptional regulator
HV319_RS18995	COG2079	MmgE PrpD family protein
HV319_RS19000	COG0372	Belongs to the citrate synthase family
HV319_RS19030	COG3829	transcription factor binding
HV319_RS19040	COG1280	lysine exporter protein (LysE YggA)
HV319_RS19045	COG3706	GGDEF domain
HV319_RS19050	COG0348	domain, Protein
HV319_RS19055	COG1737	Transcriptional regulator
HV319_RS19065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS19070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV319_RS19075	COG1120	ATPase activity
HV319_RS19080	COG4774	siderophore transport
HV319_RS19120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV319_RS19145	COG2199	diguanylate cyclase activity
HV319_RS19145	COG2203	Gaf domain
HV319_RS19155	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV319_RS19175	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV319_RS19180	COG0640	Transcriptional regulator
HV319_RS19185	COG0783	Belongs to the Dps family
HV319_RS19200	COG1342	Belongs to the UPF0251 family
HV319_RS19250	COG2826	transposase and inactivated derivatives, IS30 family
HV319_RS19275	COG5002	protein histidine kinase activity
HV319_RS19280	COG0745	RESPONSE REGULATOR receiver
HV319_RS19295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV319_RS19325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV319_RS19425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV319_RS19450	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV319_RS19475	COG0791	NLP P60 protein
HV319_RS19480	COG3034	peptidoglycan biosynthetic process
HV319_RS19485	COG0121	glutamine amidotransferase
HV319_RS19495	COG1960	acyl-CoA dehydrogenase activity
HV319_RS19500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV319_RS19510	COG2200	EAL domain
HV319_RS19525	COG3539	Fimbrial protein
HV319_RS19535	COG3121	Chaperone
HV319_RS19540	COG3188	usher protein
HV319_RS19550	COG3539	Fimbrial protein
HV319_RS19560	COG0745	RESPONSE REGULATOR receiver
HV319_RS19575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV319_RS19585	COG2226	methyltransferase
HV319_RS19595	COG1388	LysM domain
HV319_RS19595	COG0741	lytic transglycosylase activity
HV319_RS19600	COG2226	methyltransferase
HV319_RS19610	COG2814	Major facilitator Superfamily
HV319_RS19615	COG0583	DNA-binding transcription factor activity
HV319_RS19650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV319_RS19660	COG2011	ABC-type metal ion transport system permease component
HV319_RS19665	COG1464	Belongs to the NlpA lipoprotein family
HV319_RS19675	COG1720	tRNA m6t6A37 methyltransferase activity
HV319_RS19685	COG3015	lipoprotein NlpE involved in copper resistance
HV319_RS19690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV319_RS19705	COG4568	rho-dependent transcription termination
HV319_RS19715	COG0346	lactoylglutathione lyase activity
HV319_RS19755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV319_RS19760	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV319_RS19775	COG0575	Belongs to the CDS family
HV319_RS19785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV319_RS19830	COG3835	regulator
HV319_RS19855	COG2860	membrane
HV319_RS19880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV319_RS19885	COG1120	ATPase activity
HV319_RS19890	COG4774	siderophore transport
HV319_RS19895	COG3539	Fimbrial protein
HV319_RS19915	COG3121	Chaperone
HV319_RS19925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV319_RS19930	COG1643	Atp-dependent helicase
HV319_RS19935	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV319_RS19955	COG0617	tRNA 3'-terminal CCA addition
HV319_RS19960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV319_RS19980	COG0726	polysaccharide deacetylase
HV319_RS19985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS19990	COG0842	Transport permease protein
HV319_RS19995	COG1131	(ABC) transporter
HV319_RS20000	COG0288	reversible hydration of carbon dioxide
HV319_RS20005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV319_RS20055	COG3064	Membrane
HV319_RS20070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV319_RS20075	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV319_RS20080	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV319_RS20095	COG2211	Major facilitator Superfamily
HV319_RS20100	COG3940	Belongs to the glycosyl hydrolase 43 family
HV319_RS20105	COG3725	Membrane protein required for beta-lactamase induction
HV319_RS20120	COG4969	Belongs to the N-Me-Phe pilin family
HV319_RS20125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV319_RS20130	COG1459	type II secretion system
HV319_RS20140	COG0237	dephospho-CoA kinase activity
HV319_RS20155	COG0494	nUDIX hydrolase
HV319_RS20175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV319_RS20180	COG0849	cell division
HV319_RS20190	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV319_RS20205	COG0772	Belongs to the SEDS family
HV319_RS20210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV319_RS20220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV319_RS20225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV319_RS20230	COG0768	penicillin binding
HV319_RS20260	COG0028	Belongs to the TPP enzyme family
HV319_RS20295	COG1609	Transcriptional regulator
HV319_RS20305	COG1028	Short-chain dehydrogenase reductase Sdr
HV319_RS20310	COG2814	Major facilitator Superfamily
HV319_RS20340	COG0586	Pfam SNARE associated Golgi protein
HV319_RS20360	COG0235	Class ii aldolase
HV319_RS20370	COG0417	DNA replication proofreading
HV319_RS20380	COG0564	pseudouridine synthase activity
HV319_RS20390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV319_RS20440	COG2271	Major facilitator Superfamily
HV319_RS20450	COG0644	oxidoreductase
HV319_RS20505	COG0505	Belongs to the CarA family
HV319_RS20525	COG1047	Peptidyl-prolyl cis-trans
HV319_RS20540	COG0196	riboflavin kinase activity
HV319_RS20560	COG0583	DNA-binding transcription factor activity
HV319_RS20575	COG0443	Heat shock 70 kDa protein
HV319_RS20585	COG4735	regulation of single-species biofilm formation
HV319_RS20590	COG1584	GPR1 FUN34 yaaH family protein
HV319_RS20600	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV319_RS20610	COG1115	amino acid carrier protein
HV319_RS20620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV319_RS20630	COG0527	aspartate kinase activity
HV319_RS20630	COG0460	homoserine dehydrogenase
HV319_RS20640	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV319_RS20650	COG0745	RESPONSE REGULATOR receiver
HV319_RS20655	COG4452	Inner membrane protein CreD
HV319_RS20660	COG2205	protein histidine kinase activity
HV319_RS20665	COG0745	RESPONSE REGULATOR receiver
HV319_RS20670	COG3045	CreA protein
HV319_RS20675	COG2207	Transcriptional regulator
HV319_RS20675	COG3708	Transcriptional regulator
HV319_RS20695	COG0741	lytic transglycosylase activity
HV319_RS20700	COG0488	(ABC) transporter
HV319_RS20715	COG0560	Phosphoserine phosphatase
HV319_RS20720	COG3726	membrane protein affecting hemolysin expression
HV319_RS20760	COG1328	CTP reductase activity
HV319_RS20765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV319_RS20770	COG0084	hydrolase, TatD family'
HV319_RS20775	COG4667	esterase of the alpha-beta hydrolase superfamily
HV319_RS20780	COG5487	UPF0391 membrane protein
HV319_RS20785	COG2823	Periplasmic or secreted lipoprotein
HV319_RS20795	COG1011	Hydrolase
HV319_RS20800	COG0456	acetyltransferase
HV319_RS20805	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV319_RS20835	COG3706	GGDEF domain
HV319_RS20840	COG4114	ferric iron reductase
HV319_RS20845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV319_RS20850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV319_RS20860	COG2197	response regulator
HV319_RS20865	COG2966	Psort location CytoplasmicMembrane, score
HV319_RS20880	COG1484	DNA-dependent DNA replication
HV319_RS20900	COG1063	alcohol dehydrogenase
HV319_RS20905	COG1802	Transcriptional regulator
HV319_RS20910	COG2271	Major facilitator Superfamily
HV319_RS20920	COG0840	transmembrane signaling receptor activity
HV319_RS20925	COG1966	Carbon starvation protein
HV319_RS20930	COG2879	small protein
HV319_RS20935	COG0523	cobalamin synthesis protein
HV319_RS20945	COG1566	PFAM secretion protein HlyD family protein
HV319_RS20955	COG5457	Domain of unknown function (DUF1127)
HV319_RS20960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV319_RS20965	COG5464	transposase or invertase
HV319_RS20985	COG0626	cystathionine gamma-synthase activity
HV319_RS20990	COG1301	dicarboxylic acid transport
HV319_RS20995	COG0583	DNA-binding transcription factor activity
HV319_RS21000	COG2733	membrane
HV319_RS21010	COG0477	Major facilitator Superfamily
HV319_RS21030	COG2186	Transcriptional regulator
HV319_RS21035	COG0246	Mannitol dehydrogenase
HV319_RS21045	COG2610	gluconate transmembrane transporter activity
HV319_RS21050	COG1556	Lactate utilization protein
HV319_RS21055	COG1139	Iron-sulfur cluster binding protein
HV319_RS21060	COG0247	lactate metabolic process
HV319_RS21065	COG1620	l-lactate permease
HV319_RS21135	COG2003	Belongs to the UPF0758 family
HV319_RS21180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV319_RS21185	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HV319_RS21195	COG0732	type I restriction modification DNA specificity domain
HV319_RS21215	COG0582	viral genome integration into host DNA
HV319_RS21240	COG1064	alcohol dehydrogenase
HV319_RS21245	COG0433	COG0433 Predicted ATPase
HV319_RS21250	COG0795	lipopolysaccharide-transporting ATPase activity
HV319_RS21255	COG0795	lipopolysaccharide-transporting ATPase activity
HV319_RS21265	COG2927	DNA polymerase III (CHI subunit)
HV319_RS21270	COG0525	valine-tRNA ligase activity
HV319_RS21300	COG2731	YhcH YjgK YiaL family protein
HV319_RS21305	COG2235	arginine
HV319_RS21315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV319_RS21320	COG1288	antiporter activity
HV319_RS21325	COG1438	arginine binding
HV319_RS21375	COG0383	alpha-mannosidase activity
HV319_RS21380	COG0366	Alpha amylase catalytic
HV319_RS21385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS21385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS21385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS21400	COG2026	Addiction module toxin, RelE StbE family
HV319_RS21405	COG3077	Addiction module antitoxin, RelB DinJ family
HV319_RS21410	COG3711	transcriptional antiterminator
HV319_RS21410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS21425	COG3964	amidohydrolase
HV319_RS21460	COG0312	modulator of DNA gyrase
HV319_RS21470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV319_RS21480	COG0840	transmembrane signaling receptor activity
HV319_RS21485	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV319_RS21490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV319_RS21495	COG1129	ABC transporter
HV319_RS21500	COG1879	ABC-type sugar transport system periplasmic component
HV319_RS21510	COG2105	PFAM AIG2 family protein
HV319_RS21515	COG2911	Protein conserved in bacteria
HV319_RS21520	COG0729	surface antigen
HV319_RS21530	COG1253	flavin adenine dinucleotide binding
HV319_RS21540	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV319_RS21545	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV319_RS21555	COG1733	regulation of RNA biosynthetic process
HV319_RS21560	COG0702	epimerase
HV319_RS21570	COG0697	spore germination
HV319_RS21575	COG0840	transmembrane signaling receptor activity
HV319_RS21585	COG1113	amino acid transport
HV319_RS21590	COG0545	Peptidyl-prolyl cis-trans isomerase
HV319_RS21595	COG3061	Opacity-associated protein A
HV319_RS21610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV319_RS21625	COG0730	response to heat
HV319_RS21675	COG1073	alpha beta
HV319_RS21680	COG3650	response to hydrogen peroxide
HV319_RS21690	COG1960	acyl-CoA dehydrogenase activity
HV319_RS21695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV319_RS21700	COG0557	exoribonuclease II activity
HV319_RS21715	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV319_RS21720	COG0330	HflC and HflK could
HV319_RS21725	COG0330	HflC and HflK could
HV319_RS21730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV319_RS21735	COG1923	regulation of RNA biosynthetic process
HV319_RS21750	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV319_RS21755	COG0802	atpase or kinase
HV319_RS21760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV319_RS21760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV319_RS21765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV319_RS21800	COG1511	domain protein
HV319_RS21800	COG3264	Mechanosensitive ion channel
HV319_RS21815	COG1053	succinate dehydrogenase
HV319_RS21820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV319_RS21875	COG1509	lysine 2,3-aminomutase activity
HV319_RS21900	COG0531	amino acid
HV319_RS21905	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV319_RS21910	COG1027	Aspartate ammonia-lyase
HV319_RS21915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV319_RS21930	COG1309	transcriptional regulator
HV319_RS21940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV319_RS21950	COG0210	DNA helicase
HV319_RS22025	COG2223	nitrite transmembrane transporter activity
HV319_RS22035	COG1609	Transcriptional regulator
HV319_RS22245	COG0629	single-stranded DNA binding
HV319_RS22255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV319_RS22315	COG3039	Transposase
HV319_RS22325	COG0366	Alpha amylase catalytic
HV319_RS22330	COG2190	(PTS) system
HV319_RS22330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV319_RS22330	COG1263	PTS System
HV319_RS22385	COG3290	protein histidine kinase activity
HV319_RS22390	COG4565	transcriptional regulatory protein
HV319_RS22395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV319_RS22400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS22400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV319_RS22405	COG3647	Membrane
HV319_RS22415	COG2211	Major facilitator Superfamily
HV319_RS22420	COG1486	melibiose metabolic process
HV319_RS22425	COG2169	Transcriptional regulator
HV319_RS22430	COG1982	Orn Lys Arg decarboxylase major
HV319_RS22450	COG0531	amino acid
HV319_RS22490	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV319_RS22495	COG2824	Alkylphosphonate utilization operon protein PhnA
HV319_RS22500	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV319_RS22505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV319_RS22510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV319_RS22515	COG3639	organic phosphonate transmembrane transporter activity
HV319_RS22520	COG2188	Transcriptional regulator
HV319_RS22525	COG3624	Phosphonate C-P lyase system protein PhnG
HV319_RS22530	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV319_RS22535	COG3626	phosphonate metabolism
HV319_RS22540	COG3627	carbon phosphorus lyase activity
HV319_RS22545	COG4107	phosphonate C-P lyase system protein PhnK
HV319_RS22550	COG4778	phosphonate C-P lyase system protein PhnL
HV319_RS22555	COG3454	Phosphonate metabolism
HV319_RS22565	COG0456	acetyltransferase
HV319_RS22570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV319_RS22585	COG1129	ABC transporter
HV319_RS22590	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV319_RS22620	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV319_RS22630	COG1566	PFAM secretion protein HlyD family protein
HV319_RS22635	COG1289	transmembrane transporter activity
HV319_RS22640	COG1538	Outer membrane efflux protein
HV319_RS22650	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV319_RS22655	COG1301	dicarboxylic acid transport
HV319_RS22660	COG4235	cytochrome complex assembly
HV319_RS22665	COG3088	subunit of a heme lyase
HV319_RS22670	COG1138	Cytochrome C-type biogenesis protein
HV319_RS22675	COG3301	Polysulphide reductase, NrfD
HV319_RS22680	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS22685	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV319_RS22695	COG2801	Transposase and inactivated derivatives
HV319_RS22710	COG3162	membrane
HV319_RS22720	COG1346	cytolysis
HV319_RS22725	COG1380	Effector of murein hydrolase LrgA
HV319_RS22730	COG0583	DNA-binding transcription factor activity
HV319_RS22735	COG0025	NhaP-type Na H and K H
HV319_RS22740	COG2252	PERMEase
HV319_RS22745	COG0789	Transcriptional regulator
HV319_RS22755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV319_RS22770	COG0629	single-stranded DNA binding
HV319_RS22775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV319_RS22780	COG2315	Protein conserved in bacteria
HV319_RS22785	COG3700	Belongs to the class B bacterial acid phosphatase family
HV319_RS22790	COG1448	Aminotransferase
HV319_RS22800	COG0305	Participates in initiation and elongation during chromosome replication
HV319_RS22815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV319_RS22880	COG1196	nuclear chromosome segregation
HV319_RS22930	COG1030	water channel activity
HV319_RS22950	COG4220	transposase activity
HV319_RS22970	COG3179	chitinase
HV319_RS23000	COG1403	HNH endonuclease
HV319_RS23005	COG3646	Phage regulatory protein
HV319_RS23005	COG3645	SOS response
HV319_RS23020	COG4725	Belongs to the MT-A70-like family
HV319_RS23025	COG4626	Terminase
HV319_RS23025	COG1802	Transcriptional regulator
HV319_RS23050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV319_RS23065	COG5532	Uncharacterized conserved protein (DUF2303)
HV319_RS23070	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HV319_RS23125	COG0735	belongs to the Fur family
HV319_RS23130	COG3237	CsbD-like
HV319_RS23135	COG0534	Mate efflux family protein
HV319_RS23145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV319_RS23180	COG2182	Extracellular solute-binding protein
HV319_RS23195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV319_RS23200	COG1757	Na H antiporter
HV319_RS23205	COG3223	Belongs to the PsiE family
HV319_RS23210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV319_RS23215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV319_RS23240	COG0527	aspartate kinase activity
HV319_RS23245	COG3541	Predicted nucleotidyltransferase
HV319_RS23255	COG4650	regulator
HV319_RS23275	COG1187	pseudouridine synthase activity
HV319_RS23315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV319_RS23355	COG1410	methionine synthase
HV319_RS23355	COG0646	methionine synthase
HV319_RS23365	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV319_RS23375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV319_RS23385	COG0456	acetyltransferase
HV319_RS23410	COG0151	Belongs to the GarS family
HV319_RS23420	COG4191	Histidine kinase
HV319_RS23480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV319_RS23485	COG2104	thiamine diphosphate biosynthetic process
HV319_RS23500	COG1278	Cold shock
HV319_RS23510	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV319_RS23545	COG0250	Participates in transcription elongation, termination and antitermination
HV319_RS23590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV319_RS23650	COG0583	DNA-binding transcription factor activity
HV319_RS23685	COG2207	Transcriptional regulator
HV319_RS23695	COG0371	Dehydrogenase
HV319_RS23705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV319_RS23710	COG0583	DNA-binding transcription factor activity
HV319_RS23720	COG0737	Belongs to the 5'-nucleotidase family
HV319_RS23730	COG0460	homoserine dehydrogenase
HV319_RS23730	COG0527	aspartate kinase activity
HV319_RS23735	COG0626	cystathionine gamma-synthase activity
HV319_RS23745	COG2211	Major facilitator Superfamily
HV319_RS23760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV319_RS23765	COG1609	Transcriptional regulator
HV319_RS23770	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV319_RS23785	COG1575	Belongs to the MenA family. Type 1 subfamily
HV319_RS23800	COG3074	FtsZ-dependent cytokinesis
HV319_RS23805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV319_RS23815	COG1494	fructose-1,6-bisphosphatase
HV319_RS23825	COG3152	Membrane
HV319_RS23870	COG3678	ATP-independent chaperone mediated protein folding
HV319_RS23875	COG0745	RESPONSE REGULATOR receiver
HV319_RS23880	COG2205	protein histidine kinase activity
HV319_RS23885	COG2258	MOSC domain
HV319_RS23890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV319_RS23935	COG1454	alcohol dehydrogenase
HV319_RS23950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV319_RS23960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS23965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS23965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV319_RS23970	COG1363	Peptidase, m42
HV319_RS23975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV319_RS23975	COG3711	transcriptional antiterminator
HV319_RS24005	COG0437	4 iron, 4 sulfur cluster binding
HV319_RS24010	COG2864	formate dehydrogenase
HV319_RS24025	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV319_RS24035	COG0456	acetyltransferase
HV319_RS24040	COG1490	D-aminoacyl-tRNA deacylase activity
HV319_RS24050	COG1011	Hydrolase
HV319_RS24055	COG1349	DNA-binding transcription factor activity
HV319_RS24060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS24070	COG3684	Belongs to the aldolase LacD family
HV319_RS24080	COG2017	converts alpha-aldose to the beta-anomer
HV319_RS24085	COG1501	Belongs to the glycosyl hydrolase 31 family
HV319_RS24115	COG3852	Histidine kinase
HV319_RS24120	COG2204	response regulator
HV319_RS24130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV319_RS24150	COG0204	Acyl-transferase
HV319_RS24165	COG3084	Protein conserved in bacteria
HV319_RS24170	COG0746	molybdenum cofactor guanylyltransferase activity
HV319_RS24175	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV319_RS24215	COG1739	Uncharacterized protein family UPF0029
HV319_RS24235	COG1609	Transcriptional regulator
HV319_RS24240	COG1940	carbohydrate kinase activity
HV319_RS24265	COG0805	protein transport
HV319_RS24315	COG0583	DNA-binding transcription factor activity
HV319_RS24320	COG0697	spore germination
HV319_RS24325	COG0561	phosphatase activity
HV319_RS24330	COG2267	carboxylic ester hydrolase activity
HV319_RS24335	COG1280	lysine exporter protein (LysE YggA)
HV319_RS24345	COG1280	lysine exporter protein (LysE YggA)
HV319_RS24380	COG1011	Hydrolase
HV319_RS24425	COG2959	enzyme of heme biosynthesis
HV319_RS24430	COG3071	HemY protein
HV319_RS24475	COG2244	polysaccharide biosynthetic process
HV319_RS24480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV319_RS24485	COG0456	acetyltransferase
HV319_RS24490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV319_RS24510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV319_RS24520	COG3118	belongs to the thioredoxin family
HV319_RS24540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV319_RS24560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV319_RS24570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV319_RS24575	COG3978	acetolactate synthase activity
HV319_RS24595	COG3085	chromosome segregation
HV319_RS24635	COG2186	Transcriptional regulator
HV319_RS24640	COG0477	Major facilitator Superfamily
HV319_RS24645	COG1609	Transcriptional regulator
HV319_RS24650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV319_RS24655	COG1879	ABC-type sugar transport system periplasmic component
HV319_RS24660	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV319_RS24670	COG1869	D-ribose catabolic process
HV319_RS24695	COG1522	sequence-specific DNA binding
HV319_RS24700	COG0716	FMN binding
HV319_RS24715	COG3312	ion transport
HV319_RS24740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV319_RS24750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV319_RS24755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV319_RS24770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV319_RS24775	COG0573	inorganic phosphate transmembrane transporter activity
HV319_RS24780	COG0581	inorganic phosphate transmembrane transporter activity
HV319_RS24790	COG0704	Plays a role in the regulation of phosphate uptake
HV319_RS24795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV319_RS24800	COG2252	PERMEase
HV319_RS24805	COG0431	NADPH-dependent FMN reductase
HV319_RS24810	COG2091	lysine biosynthetic process via aminoadipic acid
HV319_RS24845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV319_RS24890	COG0058	SHG alpha-glucan phosphorylase activity
HV319_RS24895	COG0033	Phosphoglucomutase
HV319_RS24905	COG2826	transposase and inactivated derivatives, IS30 family
HV319_RS24975	COG0789	Transcriptional regulator
HV319_RS24990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV319_RS25000	COG0589	response to stress
HV319_RS25020	COG4644	lycopene metabolic process
HV319_RS25030	COG0653	protein targeting
HV319_RS25050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV319_RS25055	COG1127	ABC transporter
HV319_RS25130	COG2801	Transposase and inactivated derivatives
HV319_RS25175	COG2203	Gaf domain
HV319_RS25175	COG2199	diguanylate cyclase activity
HV319_RS25210	COG1192	Involved in chromosome partitioning
HV319_RS25235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV319_RS25260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV319_RS25275	COG0583	DNA-binding transcription factor activity
HV319_RS25285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV319_RS25300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HV319_RS25320	COG1846	Transcriptional regulator
HV319_RS25325	COG0583	DNA-binding transcription factor activity
HV319_RS25335	COG2948	multi-organism process
HV319_RS25415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV319_RS25460	COG1528	Iron-storage protein
HV319_RS25510	COG1136	(ABC) transporter
HV319_RS25525	COG1309	transcriptional regulator
HV319_RS25555	COG0589	response to stress
HV319_RS25560	COG0659	secondary active sulfate transmembrane transporter activity
HV319_RS25595	COG3039	Transposase
HV319_RS25605	COG3344	reverse transcriptase
HV319_RS25615	COG2826	transposase and inactivated derivatives, IS30 family
HV319_RS25645	COG1121	(ABC) transporter
HV319_RS25680	COG2135	peptidase activity
HV319_RS25730	COG0629	single-stranded DNA binding
HV319_RS26005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV319_RS26320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV319_RS26335	COG0741	lytic transglycosylase activity
HV319_RS26460	COG2002	toxin-antitoxin pair type II binding
HV319_RS26555	COG2003	Belongs to the UPF0758 family
HV319_RS26595	COG0534	Mate efflux family protein
HV319_RS26605	COG0583	DNA-binding transcription factor activity
HV319_RS26675	COG2261	transglycosylase associated protein
HV319_RS26680	COG3383	formate dehydrogenase (NAD+) activity
HV319_RS26695	COG3615	Tellurite resistance protein tehB
HV319_RS26705	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV319_RS26710	COG1124	(ABC) transporter
HV319_RS26720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV319_RS26725	COG0601	transmembrane transport
HV319_RS26730	COG0747	negative chemotaxis
HV319_RS26735	COG4771	TonB-dependent receptor
HV319_RS26785	COG0431	NADPH-dependent FMN reductase
HV319_RS26805	COG0538	isocitrate dehydrogenase activity
HV319_RS26835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV319_RS26850	COG2850	peptidyl-arginine hydroxylation
HV319_RS26870	COG1177	transmembrane transport
HV319_RS26880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV319_RS26890	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV319_RS26895	COG1136	(ABC) transporter
HV319_RS26900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV319_RS26905	COG4763	Acyl-transferase
HV319_RS26910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV319_RS26915	COG1388	LysM domain
HV319_RS26915	COG1376	ErfK ybiS ycfS ynhG family protein
HV319_RS26925	COG1309	transcriptional regulator
HV319_RS26935	COG3134	Outer membrane lipoprotein
HV319_RS26940	COG1252	NADH dehydrogenase
HV319_RS26965	COG5633	Lipoprotein
HV319_RS26970	COG0537	adenosine 5'-monophosphoramidase activity
HV319_RS26975	COG0583	DNA-binding transcription factor activity
HV319_RS26985	COG0309	Hydrogenase expression formation protein (HypE)
HV319_RS26990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV319_RS26995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV319_RS27000	COG2223	nitrite transmembrane transporter activity