locus-tag	class	description
HV325_RS00010	COG0592	DNA-directed DNA polymerase activity
HV325_RS00025	COG0561	phosphatase activity
HV325_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV325_RS00040	COG5645	(Lipo)protein
HV325_RS00060	COG2149	membrane
HV325_RS00070	COG0641	radical SAM
HV325_RS00080	COG2610	gluconate transmembrane transporter activity
HV325_RS00085	COG0583	DNA-binding transcription factor activity
HV325_RS00095	COG2814	Major facilitator Superfamily
HV325_RS00115	COG0028	Belongs to the TPP enzyme family
HV325_RS00120	COG0440	acetolactate synthase activity
HV325_RS00125	COG1349	DNA-binding transcription factor activity
HV325_RS00135	COG0738	Major facilitator superfamily
HV325_RS00145	COG2197	response regulator
HV325_RS00175	COG3620	sequence-specific DNA binding
HV325_RS00185	COG2723	6-phospho-beta-galactosidase activity
HV325_RS00210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS00210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS00215	COG3715	PTS system
HV325_RS00220	COG3716	PTS system mannose fructose sorbose family IID component
HV325_RS00235	COG5464	transposase or invertase
HV325_RS00240	COG1464	Belongs to the NlpA lipoprotein family
HV325_RS00245	COG0697	spore germination
HV325_RS00255	COG0604	alcohol dehydrogenase
HV325_RS00260	COG0583	DNA-binding transcription factor activity
HV325_RS00280	COG2771	luxR family
HV325_RS00320	COG2211	Major facilitator Superfamily
HV325_RS00325	COG1501	Belongs to the glycosyl hydrolase 31 family
HV325_RS00330	COG3711	transcriptional antiterminator
HV325_RS00335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS00335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS00335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS00340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS00345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS00345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS00355	COG0191	fructose-bisphosphate aldolase activity
HV325_RS00365	COG2982	Protein involved in outer membrane biogenesis
HV325_RS00370	COG2233	PERMEase
HV325_RS00375	COG0786	glutamate:sodium symporter activity
HV325_RS00380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV325_RS00385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV325_RS00390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV325_RS00410	COG2860	membrane
HV325_RS00420	COG0582	viral genome integration into host DNA
HV325_RS00450	COG1561	YicC-like family, N-terminal region
HV325_RS00475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV325_RS00490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV325_RS00505	COG1519	Transferase
HV325_RS00510	COG0438	transferase activity, transferring glycosyl groups
HV325_RS00515	COG0515	serine threonine protein kinase
HV325_RS00520	COG1442	glycosyl transferase family 8
HV325_RS00525	COG1442	glycosyl transferase family 8
HV325_RS00535	COG0859	PFAM glycosyl transferase family 9
HV325_RS00540	COG1215	transferase activity, transferring glycosyl groups
HV325_RS00545	COG3307	-O-antigen
HV325_RS00555	COG0859	PFAM glycosyl transferase family 9
HV325_RS00575	COG1216	Glycosyl transferase, family 2
HV325_RS00580	COG2861	carbohydrate metabolic process
HV325_RS00585	COG4942	peptidase
HV325_RS00595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV325_RS00600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV325_RS00615	COG1045	serine acetyltransferase
HV325_RS00620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV325_RS00625	COG2271	Major facilitator Superfamily
HV325_RS00635	COG2186	Transcriptional regulator
HV325_RS00655	COG3722	fumarate hydratase activity
HV325_RS00665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS00665	COG2213	PTS system mannitol-specific
HV325_RS00675	COG1566	PFAM secretion protein HlyD family protein
HV325_RS00680	COG0625	glutathione transferase activity
HV325_RS00690	COG3276	selenocysteine insertion sequence binding
HV325_RS00695	COG1454	alcohol dehydrogenase
HV325_RS00700	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS00710	COG1566	PFAM secretion protein HlyD family protein
HV325_RS00715	COG0583	DNA-binding transcription factor activity
HV325_RS00720	COG3713	MltA-interacting MipA family protein
HV325_RS00730	COG2211	Major facilitator Superfamily
HV325_RS00735	COG4977	sequence-specific DNA binding
HV325_RS00735	COG1917	Cupin 2, conserved barrel domain protein
HV325_RS00740	COG0235	Class ii aldolase
HV325_RS00745	COG3623	hexulose-6-phosphate isomerase
HV325_RS00750	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV325_RS00755	COG1070	Carbohydrate kinase
HV325_RS00760	COG2271	Major facilitator Superfamily
HV325_RS00770	COG2731	YhcH YjgK YiaL family protein
HV325_RS00780	COG1414	Transcriptional regulator
HV325_RS00785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV325_RS00790	COG3977	Valine--pyruvate aminotransferase
HV325_RS00795	COG0366	Alpha amylase catalytic
HV325_RS00800	COG2992	FlgJ-related protein
HV325_RS00805	COG1609	Transcriptional regulator
HV325_RS00805	COG2207	Transcriptional regulator
HV325_RS00815	COG1070	Carbohydrate kinase
HV325_RS00820	COG4682	membrane
HV325_RS00825	COG3274	enterobacterial common antigen metabolic process
HV325_RS00850	COG1278	Cold shock
HV325_RS00855	COG2944	sequence-specific DNA binding
HV325_RS00870	COG2814	Major facilitator Superfamily
HV325_RS00875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV325_RS00885	COG1609	Transcriptional regulator
HV325_RS00890	COG2885	chlorophyll binding
HV325_RS00895	COG0243	molybdopterin cofactor binding
HV325_RS00900	COG0456	acetyltransferase
HV325_RS00905	COG2818	Glycosylase
HV325_RS00910	COG5571	outer membrane autotransporter
HV325_RS00915	COG2223	nitrite transmembrane transporter activity
HV325_RS00940	COG0747	negative chemotaxis
HV325_RS00945	COG0601	transmembrane transport
HV325_RS00950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV325_RS00955	COG0444	Belongs to the ABC transporter superfamily
HV325_RS00960	COG4608	Belongs to the ABC transporter superfamily
HV325_RS00965	COG2204	response regulator
HV325_RS00970	COG0814	amino acid
HV325_RS00975	COG0626	cystathionine gamma-synthase activity
HV325_RS00985	COG2200	EAL domain
HV325_RS00985	COG2199	diguanylate cyclase activity
HV325_RS01000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV325_RS01005	COG2200	EAL domain
HV325_RS01010	COG2982	Protein involved in outer membrane biogenesis
HV325_RS01015	COG0477	Major facilitator Superfamily
HV325_RS01020	COG1295	ribonuclease BN
HV325_RS01025	COG0583	DNA-binding transcription factor activity
HV325_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS01040	COG2200	EAL domain
HV325_RS01045	COG2197	response regulator
HV325_RS01070	COG1858	cytochrome C peroxidase
HV325_RS01080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV325_RS01085	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV325_RS01090	COG0339	signal peptide processing
HV325_RS01105	COG1959	2 iron, 2 sulfur cluster binding
HV325_RS01115	COG0589	response to stress
HV325_RS01125	COG0306	phosphate transporter
HV325_RS01130	COG2081	HI0933 family
HV325_RS01135	COG2239	Acts as a magnesium transporter
HV325_RS01140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV325_RS01145	COG1129	ABC transporter
HV325_RS01145	COG0842	Transport permease protein
HV325_RS01150	COG0842	Transport permease protein
HV325_RS01170	COG2091	lysine biosynthetic process via aminoadipic acid
HV325_RS01175	COG0628	permease
HV325_RS01180	COG0477	Major facilitator Superfamily
HV325_RS01190	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV325_RS01205	COG3714	YhhN family
HV325_RS01230	COG3776	membrane
HV325_RS01235	COG0742	ribosomal rna small subunit methyltransferase
HV325_RS01240	COG0552	protein localization to endoplasmic reticulum
HV325_RS01245	COG2884	Cell division ATP-binding protein ftsE
HV325_RS01250	COG2177	Part of the ABC transporter FtsEX involved in
HV325_RS01270	COG0683	leucine binding
HV325_RS01280	COG4177	L-phenylalanine transmembrane transporter activity
HV325_RS01285	COG0411	ABC transporter
HV325_RS01320	COG0584	glycerophosphoryl diester phosphodiesterase
HV325_RS01330	COG0405	Gamma-glutamyltransferase
HV325_RS01350	COG3157	Type VI secretion system effector, Hcp
HV325_RS01360	COG1247	-acetyltransferase
HV325_RS01365	COG0673	inositol 2-dehydrogenase activity
HV325_RS01370	COG1741	Belongs to the pirin family
HV325_RS01375	COG1609	Transcriptional regulator
HV325_RS01380	COG3265	gluconokinase activity
HV325_RS01385	COG2610	gluconate transmembrane transporter activity
HV325_RS01400	COG2095	MarC family integral membrane protein
HV325_RS01405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV325_RS01430	COG0058	SHG alpha-glucan phosphorylase activity
HV325_RS01435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV325_RS01450	COG1349	DNA-binding transcription factor activity
HV325_RS01460	COG0058	SHG alpha-glucan phosphorylase activity
HV325_RS01465	COG1640	4-alpha-glucanotransferase
HV325_RS01470	COG2610	gluconate transmembrane transporter activity
HV325_RS01480	COG1040	competence protein
HV325_RS01490	COG5464	transposase or invertase
HV325_RS01505	COG1918	ferrous iron import across plasma membrane
HV325_RS01510	COG2183	response to ionizing radiation
HV325_RS01515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV325_RS01520	COG0745	RESPONSE REGULATOR receiver
HV325_RS01545	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV325_RS01555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV325_RS01560	COG1011	Hydrolase
HV325_RS01570	COG0494	nUDIX hydrolase
HV325_RS01575	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV325_RS01580	COG4972	Pilus assembly protein
HV325_RS01585	COG3166	PFAM Fimbrial assembly family protein
HV325_RS01600	COG4796	Type ii and iii secretion system protein
HV325_RS01615	COG3266	domain, Protein
HV325_RS01620	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV325_RS01625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV325_RS01635	COG0180	Tryptophanyl-tRNA synthetase
HV325_RS01640	COG2188	Transcriptional regulator
HV325_RS01650	COG3457	Alanine racemase
HV325_RS01655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HV325_RS01660	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HV325_RS01675	COG0626	cystathionine gamma-synthase activity
HV325_RS01695	COG2146	nitrite reductase [NAD(P)H] activity
HV325_RS01700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV325_RS01725	COG0512	Glutamine amidotransferase of anthranilate synthase
HV325_RS01730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV325_RS01735	COG1289	transmembrane transporter activity
HV325_RS01745	COG1765	OsmC-like protein
HV325_RS01750	COG3954	Phosphoribulokinase
HV325_RS01760	COG0429	hydrolase of the alpha beta-hydrolase fold
HV325_RS01770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HV325_RS01780	COG0488	(ABC) transporter
HV325_RS01795	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV325_RS01800	COG1047	Peptidyl-prolyl cis-trans
HV325_RS01810	COG0545	Peptidyl-prolyl cis-trans isomerase
HV325_RS01815	COG2964	Protein conserved in bacteria
HV325_RS01840	COG0049	tRNA binding
HV325_RS01870	COG0051	transcription antitermination factor activity, RNA binding
HV325_RS01880	COG0088	Forms part of the polypeptide exit tunnel
HV325_RS01895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV325_RS01970	COG0200	Binds to the 23S rRNA
HV325_RS01975	COG0201	protein transport
HV325_RS01990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV325_RS02015	COG0789	Transcriptional regulator
HV325_RS02020	COG3036	rescue of stalled ribosome
HV325_RS02030	COG0569	domain protein
HV325_RS02050	COG0758	DNA mediated transformation
HV325_RS02060	COG0551	DNA topoisomerase type I activity
HV325_RS02080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV325_RS02120	COG1126	abc transporter atp-binding protein
HV325_RS02125	COG0765	amino acid transport
HV325_RS02130	COG4597	amino acid ABC transporter
HV325_RS02135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV325_RS02145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV325_RS02150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV325_RS02155	COG1309	transcriptional regulator
HV325_RS02165	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV325_RS02170	COG0582	viral genome integration into host DNA
HV325_RS02185	COG3561	AntA/AntB antirepressor
HV325_RS02265	COG0741	lytic transglycosylase activity
HV325_RS02300	COG4145	pantothenate transmembrane transporter activity
HV325_RS02305	COG3924	membrane
HV325_RS02310	COG0439	Biotin carboxylase
HV325_RS02315	COG0511	ligase activity, forming carbon-carbon bonds
HV325_RS02330	COG0604	alcohol dehydrogenase
HV325_RS02335	COG2199	diguanylate cyclase activity
HV325_RS02335	COG2200	EAL domain
HV325_RS02345	COG1077	Cell shape determining protein MreB Mrl
HV325_RS02350	COG1792	Involved in formation and maintenance of cell shape
HV325_RS02355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV325_RS02365	COG1530	ribonuclease E activity
HV325_RS02370	COG3164	Protein of unknown function
HV325_RS02375	COG0312	modulator of DNA gyrase
HV325_RS02380	COG0583	DNA-binding transcription factor activity
HV325_RS02400	COG2732	(Barnase) inhibitor
HV325_RS02420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV325_RS02425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV325_RS02430	COG3105	Protein conserved in bacteria
HV325_RS02435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV325_RS02450	COG0625	glutathione transferase activity
HV325_RS02455	COG2969	positive regulation of protein catabolic process
HV325_RS02460	COG3069	C4-dicarboxylate transmembrane transporter activity
HV325_RS02465	COG2186	Transcriptional regulator
HV325_RS02485	COG2731	YhcH YjgK YiaL family protein
HV325_RS02490	COG0402	S-adenosylhomocysteine deaminase activity
HV325_RS02495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV325_RS02500	COG0493	'glutamate synthase
HV325_RS02505	COG0067	glutamate synthase
HV325_RS02505	COG0069	glutamate synthase activity
HV325_RS02505	COG0070	glutamate synthase
HV325_RS02510	COG1242	4 iron, 4 sulfur cluster binding
HV325_RS02515	COG5002	protein histidine kinase activity
HV325_RS02515	COG2198	Histidine kinase
HV325_RS02515	COG0784	Response regulator, receiver
HV325_RS02520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV325_RS02530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS02545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV325_RS02555	COG1137	ATPase activity
HV325_RS02560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV325_RS02565	COG3117	lipopolysaccharide transmembrane transporter activity
HV325_RS02570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV325_RS02580	COG0530	calcium, potassium:sodium antiporter activity
HV325_RS02585	COG1127	ABC transporter
HV325_RS02590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV325_RS02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV325_RS02600	COG2854	intermembrane phospholipid transfer
HV325_RS02605	COG3113	response to antibiotic
HV325_RS02610	COG5007	Belongs to the BolA IbaG family
HV325_RS02620	COG3423	Transcriptional regulator
HV325_RS02625	COG0142	geranyltranstransferase activity
HV325_RS02630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV325_RS02635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV325_RS02640	COG0697	spore germination
HV325_RS02650	COG2027	D-alanyl-D-alanine carboxypeptidase
HV325_RS02660	COG1534	Rna-binding protein
HV325_RS02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV325_RS02675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV325_RS02685	COG3069	C4-dicarboxylate transmembrane transporter activity
HV325_RS02690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV325_RS02695	COG0583	DNA-binding transcription factor activity
HV325_RS02700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV325_RS02725	COG0195	Participates in both transcription termination and antitermination
HV325_RS02730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV325_RS02735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV325_RS02765	COG0513	Belongs to the DEAD box helicase family
HV325_RS02770	COG0814	amino acid
HV325_RS02775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV325_RS02780	COG0826	peptidase U32
HV325_RS02785	COG0826	peptidase U32
HV325_RS02790	COG3154	lipid carrier protein
HV325_RS02795	COG3153	acetyltransferase
HV325_RS02810	COG0702	epimerase
HV325_RS02815	COG2823	Periplasmic or secreted lipoprotein
HV325_RS02835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV325_RS02840	COG3177	Filamentation induced by cAMP protein fic
HV325_RS02845	COG0363	glucosamine-6-phosphate deaminase activity
HV325_RS02850	COG3716	PTS system mannose fructose sorbose family IID component
HV325_RS02855	COG3715	PTS system
HV325_RS02860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS02870	COG2222	sugar isomerase
HV325_RS02875	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV325_RS02880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS02885	COG3716	PTS system mannose fructose sorbose family IID component
HV325_RS02895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS02905	COG1349	DNA-binding transcription factor activity
HV325_RS02910	COG1349	DNA-binding transcription factor activity
HV325_RS02915	COG1940	carbohydrate kinase activity
HV325_RS02920	COG0673	inositol 2-dehydrogenase activity
HV325_RS02925	COG3842	ATPase activity
HV325_RS02930	COG0395	ABC-type sugar transport system, permease component
HV325_RS02935	COG1175	transmembrane transport
HV325_RS02945	COG2721	sulfolactate sulfo-lyase activity
HV325_RS02950	COG2271	Major facilitator Superfamily
HV325_RS02960	COG2084	Dehydrogenase
HV325_RS02965	COG1929	Belongs to the glycerate kinase type-1 family
HV325_RS02985	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS02995	COG0251	oxidation-reduction process
HV325_RS03000	COG1760	l-serine dehydratase
HV325_RS03005	COG0814	amino acid
HV325_RS03020	COG1741	Belongs to the pirin family
HV325_RS03025	COG0583	DNA-binding transcription factor activity
HV325_RS03030	COG3152	Membrane
HV325_RS03035	COG0435	Glutathione S-transferase
HV325_RS03040	COG2259	Doxx family
HV325_RS03050	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV325_RS03055	COG4575	ribosome binding
HV325_RS03060	COG1422	Protein of unknown function (DUF1090)
HV325_RS03070	COG0586	Pfam SNARE associated Golgi protein
HV325_RS03075	COG2186	Transcriptional regulator
HV325_RS03080	COG2271	Major facilitator Superfamily
HV325_RS03090	COG2721	sulfolactate sulfo-lyase activity
HV325_RS03110	COG0673	inositol 2-dehydrogenase activity
HV325_RS03115	COG1451	nucleotide metabolic process
HV325_RS03125	COG1902	pentaerythritol trinitrate reductase activity
HV325_RS03125	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV325_RS03130	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HV325_RS03130	COG3408	Glycogen debranching enzyme
HV325_RS03140	COG0531	amino acid
HV325_RS03145	COG2731	YhcH YjgK YiaL family protein
HV325_RS03150	COG3250	beta-galactosidase activity
HV325_RS03155	COG1609	Transcriptional regulator
HV325_RS03160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV325_RS03170	COG0840	transmembrane signaling receptor activity
HV325_RS03175	COG1695	Transcriptional regulator
HV325_RS03180	COG2375	cellular response to nickel ion
HV325_RS03190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV325_RS03265	COG4771	TonB-dependent receptor
HV325_RS03270	COG3391	amine dehydrogenase activity
HV325_RS03280	COG0358	DNA primase activity
HV325_RS03285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV325_RS03290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV325_RS03295	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV325_RS03305	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV325_RS03335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS03340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS03355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV325_RS03370	COG4991	sh3 domain protein
HV325_RS03375	COG3025	triphosphatase activity
HV325_RS03390	COG2268	Band 7 protein
HV325_RS03395	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV325_RS03415	COG3539	Fimbrial protein
HV325_RS03420	COG3121	Chaperone
HV325_RS03425	COG3188	usher protein
HV325_RS03430	COG3539	Fimbrial protein
HV325_RS03455	COG3384	dioxygenase
HV325_RS03460	COG0754	glutathionylspermidine amidase activity
HV325_RS03475	COG0494	nUDIX hydrolase
HV325_RS03480	COG3151	Protein conserved in bacteria
HV325_RS03485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV325_RS03490	COG3150	esterase
HV325_RS03495	COG0187	DNA topoisomerase II activity
HV325_RS03500	COG4977	sequence-specific DNA binding
HV325_RS03500	COG1917	Cupin 2, conserved barrel domain protein
HV325_RS03510	COG2211	Major facilitator Superfamily
HV325_RS03515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV325_RS03520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV325_RS03525	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV325_RS03540	COG3111	PFAM Bacterial OB fold (BOF) protein
HV325_RS03560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV325_RS03575	COG0471	metal ion transport
HV325_RS03580	COG0656	L-ascorbic acid biosynthetic process
HV325_RS03585	COG1979	alcohol dehydrogenase
HV325_RS03590	COG2207	Transcriptional regulator
HV325_RS03595	COG0586	Pfam SNARE associated Golgi protein
HV325_RS03600	COG0626	cystathionine gamma-synthase activity
HV325_RS03610	COG0848	biopolymer transport protein
HV325_RS03630	COG0667	Aldo Keto reductase
HV325_RS03640	COG0840	transmembrane signaling receptor activity
HV325_RS03650	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV325_RS03655	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS03660	COG5557	Pfam Polysulphide reductase, NrfD
HV325_RS03665	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV325_RS03670	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV325_RS03675	COG1773	rubredoxin
HV325_RS03685	COG0298	carbon dioxide binding
HV325_RS03690	COG0625	glutathione transferase activity
HV325_RS03695	COG0243	molybdopterin cofactor binding
HV325_RS03700	COG0754	glutathionylspermidine amidase activity
HV325_RS03710	COG1811	Na channel or pump
HV325_RS03715	COG1982	Orn Lys Arg decarboxylase major
HV325_RS03720	COG2211	Major facilitator Superfamily
HV325_RS03735	COG1194	a g-specific adenine glycosylase
HV325_RS03745	COG3171	Protein conserved in bacteria
HV325_RS03755	COG0252	asparaginase activity
HV325_RS03760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV325_RS03775	COG0762	integral membrane protein
HV325_RS03780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV325_RS03785	COG2805	Type II/IV secretion system protein
HV325_RS03800	COG0189	ligase activity
HV325_RS03805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV325_RS03810	COG2356	endonuclease I
HV325_RS03815	COG3091	SprT-like family
HV325_RS03820	COG2814	Major facilitator Superfamily
HV325_RS03840	COG1166	arginine decarboxylase activity
HV325_RS03850	COG0501	Belongs to the peptidase M48B family
HV325_RS03855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV325_RS03865	COG1122	ATPase activity
HV325_RS03895	COG0191	fructose-bisphosphate aldolase activity
HV325_RS03900	COG0668	transmembrane transport
HV325_RS03905	COG1279	arginine transmembrane transporter activity
HV325_RS03910	COG2968	Membrane
HV325_RS03915	COG0583	DNA-binding transcription factor activity
HV325_RS03920	COG0427	acetyl-CoA hydrolase
HV325_RS03925	COG1024	Enoyl-CoA hydratase
HV325_RS03930	COG1703	isobutyryl-CoA mutase activity
HV325_RS03935	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV325_RS03935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV325_RS03950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV325_RS03955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV325_RS03975	COG0006	proline dipeptidase activity
HV325_RS03980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV325_RS03985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV325_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS04010	COG2723	6-phospho-beta-galactosidase activity
HV325_RS04015	COG1737	Transcriptional regulator
HV325_RS04025	COG1272	protein, Hemolysin III
HV325_RS04035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV325_RS04060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV325_RS04080	COG4942	peptidase
HV325_RS04090	COG0582	viral genome integration into host DNA
HV325_RS04120	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV325_RS04150	COG0739	heme binding
HV325_RS04200	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS04230	COG1609	Transcriptional regulator
HV325_RS04240	COG2223	nitrite transmembrane transporter activity
HV325_RS04270	COG2132	Multicopper oxidase
HV325_RS04275	COG3667	copper resistance
HV325_RS04280	COG2372	response to copper ion
HV325_RS04285	COG1276	copper resistance
HV325_RS04290	COG0745	RESPONSE REGULATOR receiver
HV325_RS04295	COG2205	protein histidine kinase activity
HV325_RS04330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV325_RS04335	COG1393	Belongs to the ArsC family
HV325_RS04340	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS04355	COG1396	sequence-specific DNA binding
HV325_RS04370	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS04405	COG3596	GTP binding
HV325_RS04415	COG2378	regulation of single-species biofilm formation
HV325_RS04445	COG2003	Belongs to the UPF0758 family
HV325_RS04470	COG0457	Tetratricopeptide repeat
HV325_RS04475	COG1649	PFAM Uncharacterised BCR, COG1649
HV325_RS04475	COG0726	polysaccharide deacetylase
HV325_RS04480	COG1215	transferase activity, transferring glycosyl groups
HV325_RS04490	COG3592	Divergent 4Fe-4S mono-cluster
HV325_RS04495	COG2388	GCN5-related N-acetyl-transferase
HV325_RS04500	COG0583	DNA-binding transcription factor activity
HV325_RS04505	COG0666	response to abiotic stimulus
HV325_RS04515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV325_RS04520	COG1304	FMN binding
HV325_RS04530	COG0549	Belongs to the carbamate kinase family
HV325_RS04535	COG0402	S-adenosylhomocysteine deaminase activity
HV325_RS04550	COG0814	amino acid
HV325_RS04565	COG0183	Belongs to the thiolase family
HV325_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS04580	COG2814	Major facilitator Superfamily
HV325_RS04590	COG1794	racemase activity, acting on amino acids and derivatives
HV325_RS04595	COG0583	DNA-binding transcription factor activity
HV325_RS04605	COG1609	Transcriptional regulator
HV325_RS04625	COG0667	Aldo Keto reductase
HV325_RS04635	COG0861	Integral membrane protein TerC family
HV325_RS04665	COG2165	general secretion pathway protein
HV325_RS04670	COG4795	General secretion pathway protein
HV325_RS04680	COG4967	type IV pilus modification protein PilV
HV325_RS04685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV325_RS04695	COG1074	ATP-dependent DNA helicase activity
HV325_RS04700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV325_RS04705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV325_RS04705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV325_RS04710	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV325_RS04730	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV325_RS04735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV325_RS04740	COG2166	iron-sulfur cluster assembly
HV325_RS04745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV325_RS04755	COG0583	DNA-binding transcription factor activity
HV325_RS04760	COG2363	Small membrane protein
HV325_RS04770	COG1349	DNA-binding transcription factor activity
HV325_RS04780	COG1070	Carbohydrate kinase
HV325_RS04790	COG1129	ABC transporter
HV325_RS04795	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS04805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV325_RS04815	COG0235	Class ii aldolase
HV325_RS04820	COG1454	alcohol dehydrogenase
HV325_RS04830	COG1760	l-serine dehydratase
HV325_RS04835	COG0814	amino acid
HV325_RS04840	COG1611	Belongs to the LOG family
HV325_RS04855	COG3098	single-species biofilm formation
HV325_RS04860	COG0564	pseudouridine synthase activity
HV325_RS04865	COG0716	FMN binding
HV325_RS04870	COG2271	Major facilitator Superfamily
HV325_RS04875	COG4948	Mandelate Racemase Muconate Lactonizing
HV325_RS04880	COG4948	Mandelate Racemase Muconate Lactonizing
HV325_RS04885	COG1929	Belongs to the glycerate kinase type-1 family
HV325_RS04890	COG4999	Histidine kinase
HV325_RS04890	COG2205	protein histidine kinase activity
HV325_RS04890	COG3850	Histidine kinase
HV325_RS04890	COG3437	response regulator, receiver
HV325_RS04900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV325_RS04905	COG3956	TIGRFAM MazG family protein
HV325_RS04920	COG1737	Transcriptional regulator
HV325_RS04925	COG2190	(PTS) system
HV325_RS04925	COG1263	PTS System
HV325_RS04925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS04930	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV325_RS04935	COG0602	queuosine metabolic process
HV325_RS04940	COG0720	synthase
HV325_RS04960	COG2234	aminopeptidase activity
HV325_RS05015	COG1388	LysM domain
HV325_RS05015	COG4942	peptidase
HV325_RS05030	COG0163	prenyltransferase activity
HV325_RS05035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV325_RS05060	COG0628	permease
HV325_RS05065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV325_RS05085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV325_RS05090	COG1882	Formate acetyltransferase
HV325_RS05105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV325_RS05110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV325_RS05115	COG1121	(ABC) transporter
HV325_RS05140	COG0309	Hydrogenase expression formation protein (HypE)
HV325_RS05145	COG0409	Hydrogenase expression formation protein
HV325_RS05150	COG0298	carbon dioxide binding
HV325_RS05155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV325_RS05160	COG0375	protein maturation
HV325_RS05170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV325_RS05175	COG0651	ATP synthesis coupled electron transport
HV325_RS05180	COG0650	Formate hydrogenlyase subunit 4
HV325_RS05185	COG3261	NADH dehydrogenase
HV325_RS05185	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV325_RS05190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV325_RS05195	COG3260	NADH ubiquinone oxidoreductase 20
HV325_RS05205	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV325_RS05215	COG2723	6-phospho-beta-galactosidase activity
HV325_RS05220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS05220	COG1263	PTS System
HV325_RS05225	COG1609	Transcriptional regulator
HV325_RS05230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV325_RS05235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV325_RS05255	COG0517	IMP dehydrogenase activity
HV325_RS05255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV325_RS05260	COG1349	DNA-binding transcription factor activity
HV325_RS05265	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS05280	COG3732	PTS system glucitol sorbitol-specific
HV325_RS05285	COG3730	PTS system glucitol sorbitol-specific
HV325_RS05290	COG2951	lytic endotransglycosylase activity
HV325_RS05295	COG1546	Belongs to the CinA family
HV325_RS05315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV325_RS05345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV325_RS05350	COG1238	metal cluster binding
HV325_RS05370	COG2814	Major facilitator Superfamily
HV325_RS05375	COG1566	PFAM secretion protein HlyD family protein
HV325_RS05380	COG1846	Transcriptional regulator
HV325_RS05390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV325_RS05395	COG2814	Major facilitator Superfamily
HV325_RS05405	COG4176	ABC-type proline glycine betaine transport system permease component
HV325_RS05445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV325_RS05475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV325_RS05480	COG0640	Transcriptional regulator
HV325_RS05485	COG0401	homolog of Blt101
HV325_RS05490	COG1652	LysM domain
HV325_RS05495	COG1802	Transcriptional regulator
HV325_RS05500	COG1113	amino acid transport
HV325_RS05505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV325_RS05510	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS05515	COG0579	oxidoreductase
HV325_RS05525	COG1285	pathogenesis
HV325_RS05530	COG2211	Major facilitator Superfamily
HV325_RS05575	COG0642	Histidine kinase
HV325_RS05580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV325_RS05615	COG0438	transferase activity, transferring glycosyl groups
HV325_RS05620	COG0297	glycogen (starch) synthase activity
HV325_RS05620	COG0438	transferase activity, transferring glycosyl groups
HV325_RS05660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV325_RS05665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV325_RS05670	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV325_RS05675	COG2271	Major facilitator Superfamily
HV325_RS05680	COG2197	response regulator
HV325_RS05685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV325_RS05685	COG0784	Response regulator, receiver
HV325_RS05685	COG2205	protein histidine kinase activity
HV325_RS05685	COG2198	Histidine kinase
HV325_RS05705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV325_RS05710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV325_RS05715	COG3065	identical protein binding
HV325_RS05730	COG3962	Belongs to the TPP enzyme family
HV325_RS05735	COG0673	inositol 2-dehydrogenase activity
HV325_RS05750	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS05760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV325_RS05770	COG3718	enzyme involved in inositol metabolism
HV325_RS05780	COG1388	LysM domain
HV325_RS05780	COG1470	cell adhesion involved in biofilm formation
HV325_RS05805	COG0582	viral genome integration into host DNA
HV325_RS05810	COG4974	Belongs to the 'phage' integrase family
HV325_RS05845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV325_RS05880	COG4695	Portal protein
HV325_RS06035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV325_RS06060	COG2867	negative regulation of translational initiation
HV325_RS06075	COG0497	DNA recombination
HV325_RS06090	COG4536	flavin adenine dinucleotide binding
HV325_RS06095	COG4137	Cytochrome C assembly protein
HV325_RS06100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV325_RS06125	COG2885	chlorophyll binding
HV325_RS06130	COG2199	diguanylate cyclase activity
HV325_RS06145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV325_RS06150	COG0287	Prephenate dehydrogenase
HV325_RS06150	COG1605	Chorismate mutase
HV325_RS06155	COG1605	Chorismate mutase
HV325_RS06155	COG0077	Prephenate dehydratase
HV325_RS06165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV325_RS06170	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV325_RS06185	COG0542	response to heat
HV325_RS06210	COG0477	Major facilitator Superfamily
HV325_RS06215	COG5544	Lipoprotein
HV325_RS06220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV325_RS06235	COG3118	belongs to the thioredoxin family
HV325_RS06240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV325_RS06260	COG0583	DNA-binding transcription factor activity
HV325_RS06265	COG0513	Belongs to the DEAD box helicase family
HV325_RS06275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV325_RS06285	COG1595	DNA-templated transcription, initiation
HV325_RS06290	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV325_RS06295	COG3026	antisigma factor binding
HV325_RS06300	COG3086	response to oxidative stress
HV325_RS06310	COG0681	Belongs to the peptidase S26 family
HV325_RS06330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV325_RS06340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV325_RS06345	COG1737	Transcriptional regulator
HV325_RS06350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV325_RS06355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS06355	COG1263	PTS System
HV325_RS06360	COG0560	Phosphoserine phosphatase
HV325_RS06380	COG2205	protein histidine kinase activity
HV325_RS06385	COG3170	Tfp pilus assembly protein FimV
HV325_RS06390	COG2204	response regulator
HV325_RS06395	COG0347	Belongs to the P(II) protein family
HV325_RS06400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV325_RS06400	COG1017	nitric oxide dioxygenase activity
HV325_RS06430	COG4638	Rieske (2fe-2S)
HV325_RS06435	COG0583	DNA-binding transcription factor activity
HV325_RS06440	COG1940	carbohydrate kinase activity
HV325_RS06445	COG0457	Tetratricopeptide repeat
HV325_RS06450	COG0477	Major facilitator Superfamily
HV325_RS06450	COG2814	Major facilitator Superfamily
HV325_RS06460	COG2814	Major facilitator Superfamily
HV325_RS06465	COG3711	transcriptional antiterminator
HV325_RS06470	COG0517	IMP dehydrogenase activity
HV325_RS06470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV325_RS06475	COG1069	ribulokinase activity
HV325_RS06485	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS06490	COG1129	ABC transporter
HV325_RS06500	COG3683	transport system, periplasmic component
HV325_RS06505	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV325_RS06525	COG1104	cysteine desulfurase activity
HV325_RS06530	COG0822	iron-sulfur transferase activity
HV325_RS06550	COG0633	Ferredoxin
HV325_RS06555	COG2975	iron-sulfur cluster assembly
HV325_RS06570	COG2897	thiosulfate sulfurtransferase activity
HV325_RS06575	COG2373	Large extracellular alpha-helical protein
HV325_RS06580	COG4953	penicillin-binding protein 1C
HV325_RS06610	COG2976	Protein conserved in bacteria
HV325_RS06625	COG3104	oligopeptide transport
HV325_RS06635	COG1645	bacterial-type flagellum-dependent swarming motility
HV325_RS06655	COG1570	exodeoxyribonuclease VII activity
HV325_RS06660	COG0516	GMP reductase activity
HV325_RS06660	COG0517	IMP dehydrogenase activity
HV325_RS06710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV325_RS06745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV325_RS06790	COG5484	DNA packaging
HV325_RS06790	COG3728	DNA packaging
HV325_RS06945	COG3179	chitinase
HV325_RS06955	COG0668	transmembrane transport
HV325_RS06965	COG2801	Transposase and inactivated derivatives
HV325_RS06970	COG3547	Transposase (IS116 IS110 IS902 family)
HV325_RS06980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HV325_RS06985	COG3077	Addiction module antitoxin, RelB DinJ family
HV325_RS06990	COG2026	Addiction module toxin, RelE StbE family
HV325_RS06995	COG2200	EAL domain
HV325_RS07000	COG0248	Ppx GppA phosphatase
HV325_RS07010	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV325_RS07020	COG2723	6-phospho-beta-galactosidase activity
HV325_RS07030	COG2233	PERMEase
HV325_RS07040	COG1393	Belongs to the ArsC family
HV325_RS07045	COG4783	chaperone-mediated protein folding
HV325_RS07050	COG0628	permease
HV325_RS07055	COG3366	ferrous iron transmembrane transporter activity
HV325_RS07060	COG0700	Nucleoside recognition
HV325_RS07065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV325_RS07070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV325_RS07075	COG2716	regulation of RNA biosynthetic process
HV325_RS07085	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV325_RS07095	COG2321	neutral zinc metallopeptidase
HV325_RS07105	COG0400	carboxylic ester hydrolase activity
HV325_RS07120	COG1393	Belongs to the ArsC family
HV325_RS07130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV325_RS07135	COG3850	Histidine kinase
HV325_RS07140	COG0493	'glutamate synthase
HV325_RS07140	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV325_RS07150	COG5342	invasion associated locus B
HV325_RS07155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV325_RS07175	COG4766	ethanolamine catabolic process
HV325_RS07180	COG4812	Cobalamin adenosyltransferase
HV325_RS07240	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HV325_RS07245	COG2207	Transcriptional regulator
HV325_RS07255	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV325_RS07275	COG2837	iron assimilation
HV325_RS07290	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV325_RS07295	COG4208	sulfate ABC transporter
HV325_RS07300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV325_RS07365	COG3530	Putative quorum-sensing-regulated virulence factor
HV325_RS07370	COG0385	Bile acid
HV325_RS07375	COG0583	DNA-binding transcription factor activity
HV325_RS07385	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV325_RS07390	COG2211	Major facilitator Superfamily
HV325_RS07395	COG0583	DNA-binding transcription factor activity
HV325_RS07425	COG3415	Transposase
HV325_RS07430	COG3415	Transposase
HV325_RS07445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV325_RS07460	COG0667	Aldo Keto reductase
HV325_RS07465	COG3961	Belongs to the TPP enzyme family
HV325_RS07480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS07485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS07490	COG0006	proline dipeptidase activity
HV325_RS07495	COG1363	Peptidase, m42
HV325_RS07500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV325_RS07500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS07500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS07515	COG2207	Transcriptional regulator
HV325_RS07520	COG3279	Response regulator of the LytR AlgR family
HV325_RS07525	COG3275	phosphorelay sensor kinase activity
HV325_RS07530	COG0436	Aminotransferase
HV325_RS07545	COG1560	Kdo2-lipid A biosynthetic process
HV325_RS07575	COG3122	Protein conserved in bacteria
HV325_RS07580	COG0840	transmembrane signaling receptor activity
HV325_RS07595	COG2116	formate transmembrane transporter activity
HV325_RS07605	COG2067	long-chain fatty acid transport protein
HV325_RS07610	COG3691	Protein conserved in bacteria
HV325_RS07625	COG2062	phosphohistidine phosphatase, SixA
HV325_RS07650	COG0730	response to heat
HV325_RS07655	COG3101	peptidyl-lysine hydroxylation
HV325_RS07670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV325_RS07690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV325_RS07700	COG0586	Pfam SNARE associated Golgi protein
HV325_RS07710	COG0285	dihydrofolate synthase activity
HV325_RS07715	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV325_RS07720	COG1286	toxin biosynthetic process
HV325_RS07725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV325_RS07730	COG0163	prenyltransferase activity
HV325_RS07740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV325_RS07745	COG4215	(ABC) transporter
HV325_RS07755	COG4598	ABC transporter
HV325_RS07760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV325_RS07765	COG1090	epimerase
HV325_RS07770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV325_RS07775	COG0625	glutathione transferase activity
HV325_RS07780	COG0625	glutathione transferase activity
HV325_RS07785	COG0622	Phosphoesterase
HV325_RS07820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV325_RS07825	COG0471	metal ion transport
HV325_RS07825	COG0490	domain, Protein
HV325_RS07835	COG0436	Aminotransferase
HV325_RS07840	COG0583	DNA-binding transcription factor activity
HV325_RS07860	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV325_RS07885	COG0839	Belongs to the complex I subunit 6 family
HV325_RS07895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV325_RS07900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV325_RS07910	COG0835	chemotaxis
HV325_RS07910	COG0784	Response regulator, receiver
HV325_RS07920	COG2153	protein acetylation
HV325_RS07925	COG4575	ribosome binding
HV325_RS07930	COG1169	isochorismate synthase
HV325_RS08015	COG5464	transposase or invertase
HV325_RS08020	COG0247	lactate metabolic process
HV325_RS08030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV325_RS08035	COG2271	Major facilitator Superfamily
HV325_RS08040	COG0584	glycerophosphoryl diester phosphodiesterase
HV325_RS08045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV325_RS08070	COG0183	Belongs to the thiolase family
HV325_RS08075	COG2031	fatty acid transporter
HV325_RS08080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV325_RS08085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV325_RS08090	COG2204	response regulator
HV325_RS08095	COG3852	Histidine kinase
HV325_RS08110	COG0642	Histidine kinase
HV325_RS08110	COG2198	Histidine kinase
HV325_RS08115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV325_RS08120	COG1477	protein flavinylation
HV325_RS08125	COG2169	Transcriptional regulator
HV325_RS08125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV325_RS08130	COG3145	DNA-N1-methyladenine dioxygenase activity
HV325_RS08135	COG4615	Cyclic peptide transporter
HV325_RS08140	COG2239	Acts as a magnesium transporter
HV325_RS08145	COG0659	secondary active sulfate transmembrane transporter activity
HV325_RS08160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV325_RS08160	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV325_RS08165	COG3062	negative regulation of establishment of protein localization
HV325_RS08175	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS08180	COG0348	domain, Protein
HV325_RS08185	COG3043	anaerobic respiration
HV325_RS08190	COG3005	denitrification pathway
HV325_RS08195	COG4133	protoheme IX ABC transporter activity
HV325_RS08205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV325_RS08210	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV325_RS08220	COG1138	Cytochrome C-type biogenesis protein
HV325_RS08225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV325_RS08230	COG3088	subunit of a heme lyase
HV325_RS08230	COG4235	cytochrome complex assembly
HV325_RS08235	COG2197	response regulator
HV325_RS08265	COG1061	Type III restriction enzyme res subunit
HV325_RS08270	COG1187	pseudouridine synthase activity
HV325_RS08275	COG2814	Major facilitator Superfamily
HV325_RS08285	COG4172	Belongs to the ABC transporter superfamily
HV325_RS08290	COG4239	(ABC) transporter, permease
HV325_RS08295	COG4174	ABC transporter (Permease)
HV325_RS08300	COG4166	transmembrane transport
HV325_RS08305	COG2200	EAL domain
HV325_RS08310	COG0791	NLP P60 protein
HV325_RS08315	COG0671	phosphoesterase, PA-phosphatase related
HV325_RS08320	COG0523	cobalamin synthesis protein
HV325_RS08325	COG0246	Mannitol dehydrogenase
HV325_RS08330	COG1312	Catalyzes the dehydration of D-mannonate
HV325_RS08335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV325_RS08340	COG3005	denitrification pathway
HV325_RS08350	COG3381	protein complex oligomerization
HV325_RS08410	COG1105	Belongs to the carbohydrate kinase PfkB family
HV325_RS08415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS08415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV325_RS08415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS08420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV325_RS08430	COG0583	DNA-binding transcription factor activity
HV325_RS08440	COG2855	membrane
HV325_RS08445	COG0583	DNA-binding transcription factor activity
HV325_RS08450	COG0833	amino acid
HV325_RS08455	COG4771	TonB-dependent receptor
HV325_RS08470	COG2311	Membrane
HV325_RS08485	COG1129	ABC transporter
HV325_RS08500	COG0493	'glutamate synthase
HV325_RS08510	COG2949	membrane
HV325_RS08520	COG1346	cytolysis
HV325_RS08535	COG2271	Major facilitator Superfamily
HV325_RS08550	COG0625	glutathione transferase activity
HV325_RS08555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV325_RS08560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV325_RS08575	COG0586	Pfam SNARE associated Golgi protein
HV325_RS08585	COG1686	Belongs to the peptidase S11 family
HV325_RS08590	COG0277	FAD linked oxidase domain protein
HV325_RS08595	COG1472	Belongs to the glycosyl hydrolase 3 family
HV325_RS08600	COG1732	Glycine betaine
HV325_RS08605	COG1174	glycine betaine transport
HV325_RS08610	COG1125	glycine betaine transport
HV325_RS08615	COG1174	glycine betaine transport
HV325_RS08625	COG0789	Transcriptional regulator
HV325_RS08630	COG3275	phosphorelay sensor kinase activity
HV325_RS08640	COG4807	Protein conserved in bacteria
HV325_RS08645	COG4808	Protein conserved in bacteria
HV325_RS08655	COG0489	protein tyrosine kinase activity
HV325_RS08670	COG3121	Chaperone
HV325_RS08675	COG3188	usher protein
HV325_RS08685	COG5455	response to cobalt ion
HV325_RS08780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV325_RS08790	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS08835	COG0351	phosphomethylpyrimidine kinase
HV325_RS08840	COG2188	Transcriptional regulator
HV325_RS08845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV325_RS08850	COG1397	ADP-ribosylglycohydrolase
HV325_RS08855	COG2211	Major facilitator Superfamily
HV325_RS08860	COG1830	Aldolase
HV325_RS08870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV325_RS08875	COG4160	amino acid transport
HV325_RS08880	COG4215	(ABC) transporter
HV325_RS08885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV325_RS08890	COG1126	abc transporter atp-binding protein
HV325_RS08905	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV325_RS08910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV325_RS08915	COG0702	epimerase
HV325_RS08920	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV325_RS08925	COG0028	Belongs to the TPP enzyme family
HV325_RS08935	COG4529	Protein conserved in bacteria
HV325_RS08940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV325_RS08950	COG2431	L-lysine efflux transmembrane transporter activity
HV325_RS08960	COG3593	DNA synthesis involved in DNA repair
HV325_RS08965	COG2990	Protein conserved in bacteria
HV325_RS08970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV325_RS08980	COG1278	Cold shock
HV325_RS08990	COG0542	response to heat
HV325_RS09005	COG0745	RESPONSE REGULATOR receiver
HV325_RS09010	COG2205	protein histidine kinase activity
HV325_RS09040	COG0443	Heat shock 70 kDa protein
HV325_RS09045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV325_RS09050	COG5002	protein histidine kinase activity
HV325_RS09050	COG5001	Diguanylate cyclase
HV325_RS09050	COG3447	MASE1 domain protein
HV325_RS09065	COG2982	Protein involved in outer membrane biogenesis
HV325_RS09070	COG1253	flavin adenine dinucleotide binding
HV325_RS09085	COG3206	protein involved in exopolysaccharide biosynthesis
HV325_RS09085	COG0489	protein tyrosine kinase activity
HV325_RS09090	COG0463	Glycosyl transferase, family 2
HV325_RS09095	COG1045	serine acetyltransferase
HV325_RS09100	COG0438	transferase activity, transferring glycosyl groups
HV325_RS09110	COG1216	Glycosyl transferase, family 2
HV325_RS09115	COG0110	maltose O-acetyltransferase activity
HV325_RS09120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV325_RS09125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV325_RS09130	COG1051	belongs to the nudix hydrolase family
HV325_RS09135	COG0297	glycogen (starch) synthase activity
HV325_RS09145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV325_RS09150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV325_RS09155	COG2244	polysaccharide biosynthetic process
HV325_RS09160	COG2327	Polysaccharide pyruvyl transferase
HV325_RS09175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV325_RS09190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV325_RS09215	COG2244	polysaccharide biosynthetic process
HV325_RS09245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV325_RS09260	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV325_RS09280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV325_RS09310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV325_RS09315	COG0583	DNA-binding transcription factor activity
HV325_RS09325	COG0531	amino acid
HV325_RS09330	COG2925	Exonuclease
HV325_RS09360	COG1289	transmembrane transporter activity
HV325_RS09395	COG4656	Part of a membrane complex involved in electron transport
HV325_RS09405	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS09585	COG1376	ErfK ybiS ycfS ynhG family protein
HV325_RS09590	COG3842	ATPase activity
HV325_RS09595	COG1178	ABC-type Fe3 transport system permease component
HV325_RS09600	COG1840	ABC-type Fe3 transport system, periplasmic component
HV325_RS09620	COG2076	Multidrug Resistance protein
HV325_RS09625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV325_RS09630	COG1418	mRNA catabolic process
HV325_RS09635	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV325_RS09640	COG3727	T/G mismatch-specific endonuclease activity
HV325_RS09645	COG0697	spore germination
HV325_RS09650	COG2354	Protein conserved in bacteria
HV325_RS09655	COG5475	Uncharacterized small protein (DUF2158)
HV325_RS09715	COG2882	bacterial-type flagellum organization
HV325_RS09720	COG1157	protein secretion by the type III secretion system
HV325_RS09755	COG2246	polysaccharide biosynthetic process
HV325_RS09760	COG0425	Belongs to the sulfur carrier protein TusA family
HV325_RS09775	COG0366	Alpha amylase catalytic
HV325_RS09845	COG2197	response regulator
HV325_RS09855	COG2197	response regulator
HV325_RS09900	COG3621	Patatin-like phospholipase
HV325_RS09905	COG1305	Transglutaminase-like
HV325_RS09915	COG2608	mercury ion transmembrane transporter activity
HV325_RS09920	COG3318	Belongs to the UPF0149 family
HV325_RS09920	COG3012	SEC-C Motif Domain Protein
HV325_RS09925	COG0814	amino acid
HV325_RS09935	COG1528	Iron-storage protein
HV325_RS09950	COG0477	Major facilitator Superfamily
HV325_RS09960	COG1528	Iron-storage protein
HV325_RS09970	COG1879	ABC-type sugar transport system periplasmic component
HV325_RS09975	COG1129	ABC transporter
HV325_RS09980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS09995	COG0589	response to stress
HV325_RS10025	COG0835	chemotaxis
HV325_RS10030	COG1301	dicarboxylic acid transport
HV325_RS10040	COG0840	transmembrane signaling receptor activity
HV325_RS10055	COG0745	RESPONSE REGULATOR receiver
HV325_RS10080	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV325_RS10095	COG3102	Protein conserved in bacteria
HV325_RS10115	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV325_RS10120	COG1801	Protein of unknown function DUF72
HV325_RS10125	COG0582	viral genome integration into host DNA
HV325_RS10195	COG4197	protein conserved in bacteria, prophage-related
HV325_RS10220	COG0484	heat shock protein binding
HV325_RS10230	COG1278	Cold shock
HV325_RS10255	COG3772	lysozyme
HV325_RS10285	COG1802	Transcriptional regulator
HV325_RS10285	COG4626	Terminase
HV325_RS10295	COG4695	Portal protein
HV325_RS10430	COG1335	isochorismatase
HV325_RS10440	COG0494	nUDIX hydrolase
HV325_RS10465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV325_RS10475	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV325_RS10480	COG0739	heme binding
HV325_RS10485	COG1560	Kdo2-lipid A biosynthetic process
HV325_RS10495	COG1737	Transcriptional regulator
HV325_RS10500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV325_RS10505	COG0129	dihydroxy-acid dehydratase activity
HV325_RS10510	COG0800	Aldolase
HV325_RS10520	COG3141	response to X-ray
HV325_RS10530	COG2979	Protein of unknown function (DUF533)
HV325_RS10535	COG1770	oligopeptidase
HV325_RS10540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV325_RS10545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV325_RS10555	COG2372	response to copper ion
HV325_RS10560	COG1276	copper resistance
HV325_RS10570	COG0582	viral genome integration into host DNA
HV325_RS10580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV325_RS10600	COG1396	sequence-specific DNA binding
HV325_RS10620	COG4626	Terminase
HV325_RS10620	COG1802	Transcriptional regulator
HV325_RS10655	COG3547	Transposase (IS116 IS110 IS902 family)
HV325_RS10685	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HV325_RS10710	COG3772	lysozyme
HV325_RS10755	COG0740	serine-type endopeptidase activity
HV325_RS10795	COG1196	nuclear chromosome segregation
HV325_RS10865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV325_RS10885	COG3008	intermembrane lipid transfer
HV325_RS10890	COG2995	paraquat-inducible protein a
HV325_RS10895	COG1956	GAF domain-containing protein
HV325_RS10915	COG2814	Major facilitator Superfamily
HV325_RS10920	COG1414	Transcriptional regulator
HV325_RS10955	COG0768	penicillin binding
HV325_RS10960	COG2226	methyltransferase
HV325_RS10975	COG3716	PTS system mannose fructose sorbose family IID component
HV325_RS10980	COG3715	PTS system
HV325_RS10985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS10985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS10990	COG1253	flavin adenine dinucleotide binding
HV325_RS10995	COG2200	EAL domain
HV325_RS11000	COG1760	l-serine dehydratase
HV325_RS11020	COG0251	oxidation-reduction process
HV325_RS11025	COG1199	ATP-dependent helicase activity
HV325_RS11030	COG1214	PFAM Peptidase M22, glycoprotease
HV325_RS11035	COG3065	identical protein binding
HV325_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
HV325_RS11045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV325_RS11050	COG0473	3-isopropylmalate dehydrogenase activity
HV325_RS11065	COG2894	cell division
HV325_RS11080	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV325_RS11110	COG2719	SpoVR family
HV325_RS11120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV325_RS11130	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV325_RS11155	COG0157	Belongs to the NadC ModD family
HV325_RS11160	COG0500	methyltransferase
HV325_RS11165	COG1120	ATPase activity
HV325_RS11190	COG1461	Dihydroxyacetone kinase
HV325_RS11195	COG2376	Dihydroxyacetone kinase
HV325_RS11200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV325_RS11225	COG0789	Transcriptional regulator
HV325_RS11230	COG2200	EAL domain
HV325_RS11275	COG0012	GTP binding
HV325_RS11290	COG0527	aspartate kinase activity
HV325_RS11295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV325_RS11300	COG0076	glutamate decarboxylase activity
HV325_RS11305	COG0659	secondary active sulfate transmembrane transporter activity
HV325_RS11335	COG2890	protein-(glutamine-N5) methyltransferase activity
HV325_RS11340	COG3094	Invasion gene expression up-regulator, SirB
HV325_RS11355	COG0387	Pfam Sodium calcium exchanger
HV325_RS11360	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV325_RS11370	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV325_RS11375	COG4932	domain protein
HV325_RS11380	COG2197	response regulator
HV325_RS11385	COG3850	Histidine kinase
HV325_RS11390	COG2223	nitrite transmembrane transporter activity
HV325_RS11395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV325_RS11400	COG1140	nitrate reductase beta subunit
HV325_RS11405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV325_RS11410	COG2181	nitrate reductase activity
HV325_RS11445	COG0788	formyltetrahydrofolate deformylase activity
HV325_RS11455	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV325_RS11460	COG0745	RESPONSE REGULATOR receiver
HV325_RS11465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV325_RS11475	COG1435	thymidine kinase activity
HV325_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS11480	COG1454	alcohol dehydrogenase
HV325_RS11485	COG2095	MarC family integral membrane protein
HV325_RS11505	COG0444	Belongs to the ABC transporter superfamily
HV325_RS11515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV325_RS11535	COG2350	Protein conserved in bacteria
HV325_RS11560	COG3047	cAMP biosynthetic process
HV325_RS11565	COG0217	transcriptional regulatory protein
HV325_RS11580	COG3706	GGDEF domain
HV325_RS11620	COG0009	L-threonylcarbamoyladenylate synthase
HV325_RS11630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV325_RS11715	COG1187	pseudouridine synthase activity
HV325_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS11730	COG0616	signal peptide processing
HV325_RS11745	COG0583	DNA-binding transcription factor activity
HV325_RS11760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV325_RS11770	COG0671	phosphoesterase, PA-phosphatase related
HV325_RS11775	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV325_RS11780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV325_RS11790	COG0023	Translation Initiation Factor
HV325_RS11800	COG1349	DNA-binding transcription factor activity
HV325_RS11810	COG5001	Diguanylate cyclase
HV325_RS11820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV325_RS11820	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV325_RS11825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV325_RS11845	COG4171	peptide transport system, permease
HV325_RS11870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV325_RS11875	COG1842	Phage shock protein A
HV325_RS11885	COG1983	PspC domain protein
HV325_RS11895	COG0366	Alpha amylase catalytic
HV325_RS11900	COG1653	transport
HV325_RS11905	COG1175	transmembrane transport
HV325_RS11910	COG0395	ABC-type sugar transport system, permease component
HV325_RS11915	COG1063	alcohol dehydrogenase
HV325_RS11920	COG1082	Xylose isomerase domain protein TIM barrel
HV325_RS11925	COG0673	inositol 2-dehydrogenase activity
HV325_RS11930	COG1554	hydrolase, family 65, central catalytic
HV325_RS11935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV325_RS11950	COG1609	Transcriptional regulator
HV325_RS11955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV325_RS11960	COG3106	COG3106 Predicted ATPase
HV325_RS11975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV325_RS11980	COG4948	Mandelate Racemase Muconate Lactonizing
HV325_RS11985	COG2866	Carboxypeptidase
HV325_RS11990	COG4166	transmembrane transport
HV325_RS12010	COG1349	DNA-binding transcription factor activity
HV325_RS12015	COG0346	lactoylglutathione lyase activity
HV325_RS12025	COG0668	transmembrane transport
HV325_RS12030	COG3182	Iron-regulated membrane protein
HV325_RS12045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV325_RS12050	COG2840	Smr protein MutS2
HV325_RS12055	COG3706	GGDEF domain
HV325_RS12070	COG0840	transmembrane signaling receptor activity
HV325_RS12080	COG0513	Belongs to the DEAD box helicase family
HV325_RS12090	COG0589	response to stress
HV325_RS12100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV325_RS12105	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV325_RS12105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV325_RS12105	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV325_RS12105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV325_RS12110	COG3042	response to heat
HV325_RS12115	COG3187	Heat shock protein
HV325_RS12120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV325_RS12125	COG2911	Protein conserved in bacteria
HV325_RS12135	COG3784	Protein of unknown function (DUF1318)
HV325_RS12145	COG1643	Atp-dependent helicase
HV325_RS12150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV325_RS12155	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS12160	COG2755	lipolytic protein G-D-S-L family
HV325_RS12160	COG0657	acetylesterase activity
HV325_RS12170	COG3038	cytochrome b561
HV325_RS12180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV325_RS12185	COG2864	formate dehydrogenase
HV325_RS12190	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS12195	COG3383	formate dehydrogenase (NAD+) activity
HV325_RS12195	COG0243	molybdopterin cofactor binding
HV325_RS12205	COG3059	membrane
HV325_RS12225	COG0840	transmembrane signaling receptor activity
HV325_RS12230	COG0583	DNA-binding transcription factor activity
HV325_RS12235	COG1227	inorganic diphosphatase activity
HV325_RS12240	COG5383	Protein conserved in bacteria
HV325_RS12250	COG2841	Protein conserved in bacteria
HV325_RS12260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV325_RS12265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV325_RS12270	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV325_RS12275	COG0500	methyltransferase
HV325_RS12285	COG0697	spore germination
HV325_RS12295	COG3135	benzoate transporter
HV325_RS12300	COG1396	sequence-specific DNA binding
HV325_RS12305	COG0826	peptidase U32
HV325_RS12320	COG1294	oxidase, subunit
HV325_RS12325	COG1271	oxidase subunit
HV325_RS12330	COG1724	mRNA binding
HV325_RS12335	COG1598	PFAM Uncharacterised protein family UPF0150
HV325_RS12340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV325_RS12345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV325_RS12350	COG3842	ATPase activity
HV325_RS12355	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV325_RS12360	COG1177	transmembrane transport
HV325_RS12370	COG2814	Major facilitator Superfamily
HV325_RS12375	COG2207	Transcriptional regulator
HV325_RS12405	COG0747	negative chemotaxis
HV325_RS12415	COG3238	Protein conserved in bacteria
HV325_RS12420	COG1247	-acetyltransferase
HV325_RS12430	COG2130	NADP-dependent
HV325_RS12450	COG0840	transmembrane signaling receptor activity
HV325_RS12455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV325_RS12460	COG1473	amidohydrolase
HV325_RS12465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV325_RS12470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV325_RS12485	COG1126	abc transporter atp-binding protein
HV325_RS12490	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS12490	COG3321	synthase
HV325_RS12490	COG0604	alcohol dehydrogenase
HV325_RS12495	COG0583	DNA-binding transcription factor activity
HV325_RS12500	COG0625	glutathione transferase activity
HV325_RS12515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV325_RS12520	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV325_RS12525	COG0384	phenazine biosynthesis protein PhzF
HV325_RS12530	COG2181	nitrate reductase activity
HV325_RS12535	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV325_RS12540	COG1140	nitrate reductase beta subunit
HV325_RS12545	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV325_RS12550	COG2223	nitrite transmembrane transporter activity
HV325_RS12575	COG0697	spore germination
HV325_RS12585	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS12590	COG2864	formate dehydrogenase
HV325_RS12595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HV325_RS12600	COG3093	addiction module antidote protein HigA
HV325_RS12610	COG0488	(ABC) transporter
HV325_RS12625	COG1764	response to oxidative stress
HV325_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS12635	COG2610	gluconate transmembrane transporter activity
HV325_RS12640	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV325_RS12650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV325_RS12655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV325_RS12665	COG4608	Belongs to the ABC transporter superfamily
HV325_RS12670	COG0444	Belongs to the ABC transporter superfamily
HV325_RS12675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV325_RS12680	COG0601	transmembrane transport
HV325_RS12685	COG0747	negative chemotaxis
HV325_RS12690	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV325_RS12705	COG0840	transmembrane signaling receptor activity
HV325_RS12730	COG4628	conserved protein (DUF2132)
HV325_RS12755	COG3121	Chaperone
HV325_RS12770	COG3121	Chaperone
HV325_RS12810	COG3781	membrane
HV325_RS12840	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS12845	COG0583	DNA-binding transcription factor activity
HV325_RS12860	COG1846	Transcriptional regulator
HV325_RS12875	COG0697	spore germination
HV325_RS12880	COG2814	Major facilitator Superfamily
HV325_RS12885	COG0410	ABC transporter
HV325_RS12890	COG1129	ABC transporter
HV325_RS12915	COG3706	GGDEF domain
HV325_RS12930	COG4221	oxidoreductase activity
HV325_RS12935	COG1802	Transcriptional regulator
HV325_RS12945	COG0246	Mannitol dehydrogenase
HV325_RS12955	COG4948	Mandelate Racemase Muconate Lactonizing
HV325_RS12970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV325_RS12985	COG0243	molybdopterin cofactor binding
HV325_RS12990	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS12995	COG3302	dmso reductase anchor subunit
HV325_RS13000	COG3381	protein complex oligomerization
HV325_RS13010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV325_RS13015	COG1940	carbohydrate kinase activity
HV325_RS13020	COG0583	DNA-binding transcription factor activity
HV325_RS13025	COG2814	Major facilitator Superfamily
HV325_RS13035	COG2205	protein histidine kinase activity
HV325_RS13040	COG0745	RESPONSE REGULATOR receiver
HV325_RS13055	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV325_RS13065	COG3591	Belongs to the peptidase S1B family
HV325_RS13080	COG0628	permease
HV325_RS13085	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV325_RS13090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV325_RS13100	COG0531	amino acid
HV325_RS13110	COG3136	membrane protein required for alginate biosynthesis
HV325_RS13115	COG0745	RESPONSE REGULATOR receiver
HV325_RS13125	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV325_RS13135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV325_RS13145	COG2205	protein histidine kinase activity
HV325_RS13160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS13160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS13170	COG5339	Protein conserved in bacteria
HV325_RS13175	COG1609	Transcriptional regulator
HV325_RS13180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS13180	COG1263	PTS System
HV325_RS13185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV325_RS13195	COG0673	inositol 2-dehydrogenase activity
HV325_RS13245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV325_RS13255	COG0625	glutathione transferase activity
HV325_RS13260	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV325_RS13275	COG3895	Periplasmic Protein
HV325_RS13300	COG1566	PFAM secretion protein HlyD family protein
HV325_RS13310	COG2032	superoxide dismutase activity
HV325_RS13315	COG4989	oxidoreductase activity
HV325_RS13320	COG3313	Fe-S protein
HV325_RS13325	COG1309	transcriptional regulator
HV325_RS13330	COG1902	pentaerythritol trinitrate reductase activity
HV325_RS13335	COG0346	lactoylglutathione lyase activity
HV325_RS13345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV325_RS13350	COG0791	NLP P60 protein
HV325_RS13355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV325_RS13360	COG2814	Major facilitator Superfamily
HV325_RS13375	COG0583	DNA-binding transcription factor activity
HV325_RS13380	COG2814	Major facilitator Superfamily
HV325_RS13385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV325_RS13390	COG0307	riboflavin synthase, alpha
HV325_RS13415	COG0251	oxidation-reduction process
HV325_RS13435	COG5001	Diguanylate cyclase
HV325_RS13435	COG3300	MHYT domain
HV325_RS13440	COG0386	Belongs to the glutathione peroxidase family
HV325_RS13445	COG0628	permease
HV325_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS13465	COG2378	regulation of single-species biofilm formation
HV325_RS13485	COG3121	Chaperone
HV325_RS13490	COG3188	usher protein
HV325_RS13505	COG4977	sequence-specific DNA binding
HV325_RS13520	COG2026	Addiction module toxin, RelE StbE family
HV325_RS13525	COG3077	Addiction module antitoxin, RelB DinJ family
HV325_RS13530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HV325_RS13540	COG3547	Transposase (IS116 IS110 IS902 family)
HV325_RS13545	COG2801	Transposase and inactivated derivatives
HV325_RS13580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV325_RS13595	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV325_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS13620	COG1113	amino acid transport
HV325_RS13630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV325_RS13640	COG0765	amino acid transport
HV325_RS13645	COG0765	amino acid transport
HV325_RS13655	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV325_RS13660	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS13670	COG2414	aldehyde ferredoxin oxidoreductase
HV325_RS13675	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS13710	COG1464	Belongs to the NlpA lipoprotein family
HV325_RS13715	COG2011	ABC-type metal ion transport system permease component
HV325_RS13735	COG1376	ErfK ybiS ycfS ynhG family protein
HV325_RS13750	COG0719	Fe-S assembly protein
HV325_RS13755	COG0396	ATPase activity
HV325_RS13760	COG0719	Fe-S assembly protein
HV325_RS13765	COG0316	Belongs to the HesB IscA family
HV325_RS13770	COG0583	DNA-binding transcription factor activity
HV325_RS13785	COG2050	protein possibly involved in aromatic compounds catabolism
HV325_RS13790	COG0247	lactate metabolic process
HV325_RS13790	COG0277	FAD linked oxidase domain protein
HV325_RS13795	COG0628	permease
HV325_RS13810	COG0738	Major facilitator superfamily
HV325_RS13815	COG2271	Major facilitator Superfamily
HV325_RS13830	COG4670	ketone body catabolic process
HV325_RS13835	COG1960	acyl-CoA dehydrogenase activity
HV325_RS13840	COG1917	Cupin 2, conserved barrel domain protein
HV325_RS13840	COG2207	Transcriptional regulator
HV325_RS13845	COG2086	electron transfer activity
HV325_RS13850	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV325_RS13855	COG0644	oxidoreductase
HV325_RS13860	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV325_RS13865	COG0318	PFAM AMP-dependent synthetase and ligase
HV325_RS13870	COG0574	Belongs to the PEP-utilizing enzyme family
HV325_RS13870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV325_RS13880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV325_RS13885	COG4256	Hemin uptake protein
HV325_RS13890	COG4771	TonB-dependent receptor
HV325_RS13895	COG3720	iron ion transport
HV325_RS13900	COG4558	Periplasmic binding protein
HV325_RS13905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV325_RS13925	COG0791	NLP P60 protein
HV325_RS13935	COG0386	Belongs to the glutathione peroxidase family
HV325_RS13970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV325_RS14005	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS14025	COG3137	Salt-induced outer membrane protein
HV325_RS14030	COG1105	Belongs to the carbohydrate kinase PfkB family
HV325_RS14035	COG3001	Fructosamine kinase
HV325_RS14045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV325_RS14050	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS14055	COG1988	membrane-bound metal-dependent
HV325_RS14070	COG0753	catalase activity
HV325_RS14080	COG1486	melibiose metabolic process
HV325_RS14085	COG1917	Cupin 2, conserved barrel domain protein
HV325_RS14085	COG2169	Transcriptional regulator
HV325_RS14090	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV325_RS14095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV325_RS14100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV325_RS14105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV325_RS14115	COG0322	excinuclease ABC activity
HV325_RS14125	COG3678	ATP-independent chaperone mediated protein folding
HV325_RS14155	COG0708	Exodeoxyribonuclease III
HV325_RS14160	COG0398	Pfam SNARE associated Golgi protein
HV325_RS14165	COG0398	Pfam SNARE associated Golgi protein
HV325_RS14170	COG4134	Bacterial extracellular solute-binding protein
HV325_RS14175	COG4135	transport system, permease component
HV325_RS14180	COG4136	ATPase activity
HV325_RS14185	COG2897	thiosulfate sulfurtransferase activity
HV325_RS14190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV325_RS14195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV325_RS14200	COG0494	nUDIX hydrolase
HV325_RS14215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV325_RS14225	COG0778	Nitroreductase
HV325_RS14230	COG0616	signal peptide processing
HV325_RS14235	COG0252	asparaginase activity
HV325_RS14240	COG1335	isochorismatase
HV325_RS14245	COG2814	Major facilitator Superfamily
HV325_RS14250	COG1349	DNA-binding transcription factor activity
HV325_RS14255	COG0667	Aldo Keto reductase
HV325_RS14260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV325_RS14265	COG0191	fructose-bisphosphate aldolase activity
HV325_RS14270	COG1063	alcohol dehydrogenase
HV325_RS14275	COG2271	Major facilitator Superfamily
HV325_RS14280	COG1063	alcohol dehydrogenase
HV325_RS14295	COG3139	Protein of unknown function (DUF1315)
HV325_RS14315	COG0656	L-ascorbic acid biosynthetic process
HV325_RS14320	COG3713	MltA-interacting MipA family protein
HV325_RS14325	COG2766	serine protein kinase
HV325_RS14335	COG2226	methyltransferase
HV325_RS14340	COG2199	diguanylate cyclase activity
HV325_RS14345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV325_RS14355	COG2207	Transcriptional regulator
HV325_RS14360	COG2807	transmembrane transport
HV325_RS14365	COG0504	CTP synthase activity
HV325_RS14370	COG3189	MarR family transcriptional regulator
HV325_RS14375	COG3042	response to heat
HV325_RS14380	COG2203	Gaf domain
HV325_RS14380	COG2199	diguanylate cyclase activity
HV325_RS14395	COG2261	transglycosylase associated protein
HV325_RS14400	COG3383	formate dehydrogenase (NAD+) activity
HV325_RS14420	COG3615	Tellurite resistance protein tehB
HV325_RS14430	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV325_RS14435	COG1124	(ABC) transporter
HV325_RS14445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV325_RS14450	COG0601	transmembrane transport
HV325_RS14455	COG0747	negative chemotaxis
HV325_RS14460	COG4771	TonB-dependent receptor
HV325_RS14495	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS14515	COG0431	NADPH-dependent FMN reductase
HV325_RS14535	COG0538	isocitrate dehydrogenase activity
HV325_RS14545	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS14560	COG0538	isocitrate dehydrogenase activity
HV325_RS14590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV325_RS14605	COG2850	peptidyl-arginine hydroxylation
HV325_RS14625	COG1177	transmembrane transport
HV325_RS14635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV325_RS14645	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV325_RS14650	COG1136	(ABC) transporter
HV325_RS14655	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV325_RS14660	COG4763	Acyl-transferase
HV325_RS14665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV325_RS14670	COG1388	LysM domain
HV325_RS14670	COG1376	ErfK ybiS ycfS ynhG family protein
HV325_RS14680	COG1309	transcriptional regulator
HV325_RS14690	COG3134	Outer membrane lipoprotein
HV325_RS14695	COG1252	NADH dehydrogenase
HV325_RS14720	COG5633	Lipoprotein
HV325_RS14725	COG0537	adenosine 5'-monophosphoramidase activity
HV325_RS14730	COG4773	Receptor
HV325_RS14735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV325_RS14740	COG3327	negative regulation of DNA-templated transcription, initiation
HV325_RS14745	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV325_RS14750	COG0183	Belongs to the thiolase family
HV325_RS14755	COG2050	protein possibly involved in aromatic compounds catabolism
HV325_RS14760	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV325_RS14765	COG1024	Enoyl-CoA hydratase
HV325_RS14770	COG1024	Enoyl-CoA hydratase
HV325_RS14775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV325_RS14780	COG2151	metal-sulfur cluster biosynthetic enzyme
HV325_RS14785	COG3396	Phenylacetate-CoA oxygenase
HV325_RS14790	COG3460	Phenylacetate-CoA oxygenase
HV325_RS14795	COG3396	Phenylacetate-CoA oxygenase
HV325_RS14800	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS14800	COG2030	dehydratase
HV325_RS14810	COG0534	Mate efflux family protein
HV325_RS14820	COG0583	DNA-binding transcription factor activity
HV325_RS14835	COG1595	DNA-templated transcription, initiation
HV325_RS14840	COG3712	iron ion homeostasis
HV325_RS14845	COG4772	TonB-dependent receptor
HV325_RS14850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV325_RS14855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV325_RS14860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV325_RS14865	COG1120	ATPase activity
HV325_RS14880	COG1073	alpha beta
HV325_RS14885	COG4221	oxidoreductase activity
HV325_RS14890	COG1073	alpha beta
HV325_RS14895	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS14915	COG3547	Transposase (IS116 IS110 IS902 family)
HV325_RS14930	COG0477	Major facilitator Superfamily
HV325_RS14935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV325_RS14950	COG0084	hydrolase, TatD family'
HV325_RS14955	COG0470	DNA polymerase III
HV325_RS14965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV325_RS14970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV325_RS14975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV325_RS15010	COG1399	metal-binding, possibly nucleic acid-binding protein
HV325_RS15020	COG0564	pseudouridine synthase activity
HV325_RS15025	COG1530	ribonuclease E activity
HV325_RS15030	COG0583	DNA-binding transcription factor activity
HV325_RS15035	COG2814	Major facilitator Superfamily
HV325_RS15065	COG4786	Flagellar basal body rod
HV325_RS15070	COG4787	bacterial-type flagellum-dependent cell motility
HV325_RS15085	COG1558	bacterial-type flagellum-dependent cell motility
HV325_RS15125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV325_RS15165	COG3038	cytochrome b561
HV325_RS15180	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS15190	COG1560	Kdo2-lipid A biosynthetic process
HV325_RS15200	COG2199	diguanylate cyclase activity
HV325_RS15210	COG5645	(Lipo)protein
HV325_RS15230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV325_RS15285	COG3381	protein complex oligomerization
HV325_RS15310	COG2962	Rard protein
HV325_RS15315	COG2990	Protein conserved in bacteria
HV325_RS15320	COG1702	phosphate starvation-inducible protein PhoH
HV325_RS15345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV325_RS15350	COG0506	proline dehydrogenase activity
HV325_RS15350	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV325_RS15350	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV325_RS15355	COG3755	Protein conserved in bacteria
HV325_RS15360	COG1309	transcriptional regulator
HV325_RS15370	COG3729	General stress protein
HV325_RS15390	COG0640	Transcriptional regulator
HV325_RS15410	COG0577	efflux transmembrane transporter activity
HV325_RS15410	COG1136	(ABC) transporter
HV325_RS15420	COG0577	efflux transmembrane transporter activity
HV325_RS15420	COG1136	(ABC) transporter
HV325_RS15435	COG0672	)-iron permease
HV325_RS15440	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV325_RS15445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV325_RS15450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV325_RS15450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV325_RS15495	COG0813	purine-nucleoside phosphorylase activity
HV325_RS15510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV325_RS15515	COG1120	ATPase activity
HV325_RS15525	COG0723	plastoquinol--plastocyanin reductase activity
HV325_RS15530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV325_RS15530	COG2857	Cytochrome c1
HV325_RS15550	COG0670	Belongs to the BI1 family
HV325_RS15575	COG1832	CoA-binding protein
HV325_RS15590	COG0210	DNA helicase
HV325_RS15595	COG3304	Inner membrane component domain
HV325_RS15600	COG1289	transmembrane transporter activity
HV325_RS15605	COG3070	regulator of competence-specific genes
HV325_RS15625	COG1067	ATP-dependent peptidase activity
HV325_RS15635	COG3130	regulation of translation
HV325_RS15640	COG3009	Protein conserved in bacteria
HV325_RS15645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV325_RS15645	COG3008	intermembrane lipid transfer
HV325_RS15650	COG2995	paraquat-inducible protein a
HV325_RS15655	COG0488	(ABC) transporter
HV325_RS15665	COG3217	Mosc domain protein beta barrel domain protein
HV325_RS15665	COG0633	Ferredoxin
HV325_RS15680	COG0431	NADPH-dependent FMN reductase
HV325_RS15685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV325_RS15695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV325_RS15700	COG1116	anion transmembrane transporter activity
HV325_RS15705	COG0308	aminopeptidase N
HV325_RS15725	COG1448	Aminotransferase
HV325_RS15730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV325_RS15735	COG3108	Peptidase M15
HV325_RS15740	COG2989	Protein conserved in bacteria
HV325_RS15750	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV325_RS15760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV325_RS15765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV325_RS15770	COG3173	Aminoglycoside phosphotransferase
HV325_RS15800	COG2333	competence protein COMEC
HV325_RS15800	COG0658	competence protein
HV325_RS15805	COG0776	regulation of translation
HV325_RS15810	COG0539	negative regulation of cytoplasmic translation
HV325_RS15820	COG0501	Belongs to the peptidase M48B family
HV325_RS15835	COG2323	membrane
HV325_RS15840	COG1944	ATP diphosphatase activity
HV325_RS15845	COG2116	formate transmembrane transporter activity
HV325_RS15850	COG1882	Formate acetyltransferase
HV325_RS15855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV325_RS15860	COG0531	amino acid
HV325_RS15870	COG1335	isochorismatase
HV325_RS15875	COG3302	dmso reductase anchor subunit
HV325_RS15880	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS15895	COG3423	Transcriptional regulator
HV325_RS15905	COG2842	Transposition protein
HV325_RS15980	COG3179	chitinase
HV325_RS16020	COG4383	Mu-like prophage protein gp29
HV325_RS16040	COG4388	Caudovirus prohead serine protease
HV325_RS16050	COG4397	Mu-like prophage major head subunit gpT
HV325_RS16060	COG4387	Mu-like prophage protein GP36
HV325_RS16140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV325_RS16155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV325_RS16165	COG1178	ABC-type Fe3 transport system permease component
HV325_RS16165	COG1674	ftsk spoiiie
HV325_RS16175	COG0492	ferredoxin-NADP+ reductase activity
HV325_RS16180	COG4988	ABC transporter
HV325_RS16185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV325_RS16200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV325_RS16205	COG0583	DNA-binding transcription factor activity
HV325_RS16215	COG1335	isochorismatase
HV325_RS16235	COG1177	transmembrane transport
HV325_RS16240	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV325_RS16245	COG3842	ATPase activity
HV325_RS16250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV325_RS16310	COG0583	DNA-binding transcription factor activity
HV325_RS16315	COG3226	Transcriptional regulator
HV325_RS16320	COG0738	Major facilitator superfamily
HV325_RS16325	COG0561	phosphatase activity
HV325_RS16335	COG2814	Major facilitator Superfamily
HV325_RS16340	COG0671	phosphoesterase, PA-phosphatase related
HV325_RS16345	COG1349	DNA-binding transcription factor activity
HV325_RS16350	COG1686	Belongs to the peptidase S11 family
HV325_RS16355	COG0625	glutathione transferase activity
HV325_RS16360	COG2133	pyrroloquinoline quinone binding
HV325_RS16395	COG1446	asparaginase
HV325_RS16405	COG0303	'Molybdopterin
HV325_RS16410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV325_RS16415	COG5464	transposase or invertase
HV325_RS16420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV325_RS16425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV325_RS16430	COG1882	Formate acetyltransferase
HV325_RS16435	COG0561	phosphatase activity
HV325_RS16445	COG0488	(ABC) transporter
HV325_RS16450	COG1376	ErfK ybiS ycfS ynhG family protein
HV325_RS16455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV325_RS16470	COG2194	sulfuric ester hydrolase activity
HV325_RS16475	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV325_RS16490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV325_RS16495	COG0765	amino acid transport
HV325_RS16500	COG1126	abc transporter atp-binding protein
HV325_RS16505	COG0668	transmembrane transport
HV325_RS16520	COG4774	siderophore transport
HV325_RS16530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV325_RS16540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV325_RS16545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV325_RS16555	COG0471	metal ion transport
HV325_RS16565	COG2188	Transcriptional regulator
HV325_RS16570	COG0513	Belongs to the DEAD box helicase family
HV325_RS16575	COG1309	transcriptional regulator
HV325_RS16585	COG1131	(ABC) transporter
HV325_RS16590	COG0842	Transport permease protein
HV325_RS16595	COG0842	Transport permease protein
HV325_RS16605	COG3568	Endonuclease Exonuclease Phosphatase
HV325_RS16610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV325_RS16615	COG0392	lysyltransferase activity
HV325_RS16620	COG0670	Belongs to the BI1 family
HV325_RS16625	COG0314	molybdopterin synthase activity
HV325_RS16630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV325_RS16640	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV325_RS16670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV325_RS16695	COG1881	PFAM PEBP family protein
HV325_RS16725	COG4677	pectinesterase activity
HV325_RS16735	COG0561	phosphatase activity
HV325_RS16745	COG4149	molybdate abc transporter
HV325_RS16750	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV325_RS16760	COG2005	Transcriptional regulator
HV325_RS16760	COG3585	molybdate ion transport
HV325_RS16765	COG1119	ATPase activity
HV325_RS16770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV325_RS16775	COG1085	galactose-1-phosphate uridylyltransferase
HV325_RS16785	COG2017	converts alpha-aldose to the beta-anomer
HV325_RS16795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV325_RS16805	COG1230	cation diffusion facilitator family transporter
HV325_RS16810	COG3201	nicotinamide mononucleotide transporter
HV325_RS16850	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV325_RS16855	COG2885	chlorophyll binding
HV325_RS16865	COG3064	Membrane
HV325_RS16870	COG0848	biopolymer transport protein
HV325_RS16875	COG0811	peptide transport
HV325_RS16880	COG0824	Thioesterase
HV325_RS16885	COG3790	cyd operon protein YbgE
HV325_RS16890	COG4890	Cyd operon protein YbgT
HV325_RS16895	COG1294	oxidase, subunit
HV325_RS16900	COG1271	oxidase subunit
HV325_RS16905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV325_RS16915	COG4865	methylaspartate mutase activity
HV325_RS16920	COG3799	methylaspartate ammonia-lyase activity
HV325_RS16935	COG1301	dicarboxylic acid transport
HV325_RS16945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS16945	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS16955	COG0583	DNA-binding transcription factor activity
HV325_RS16960	COG1648	precorrin-2 dehydrogenase activity
HV325_RS16960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV325_RS16970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV325_RS16980	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV325_RS16985	COG0567	Dehydrogenase, E1 component
HV325_RS16990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV325_RS16995	COG1053	succinate dehydrogenase
HV325_RS17000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV325_RS17005	COG2009	succinate dehydrogenase
HV325_RS17015	COG3157	Type VI secretion system effector, Hcp
HV325_RS17035	COG3180	Ammonia monooxygenase
HV325_RS17065	COG1984	allophanate hydrolase subunit 2
HV325_RS17070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV325_RS17085	COG5464	transposase or invertase
HV325_RS17095	COG3272	Protein of unknown function (DUF1722)
HV325_RS17125	COG2205	protein histidine kinase activity
HV325_RS17130	COG0745	RESPONSE REGULATOR receiver
HV325_RS17135	COG0033	Phosphoglucomutase
HV325_RS17140	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV325_RS17145	COG0596	Alpha beta hydrolase
HV325_RS17155	COG0716	FMN binding
HV325_RS17165	COG0735	belongs to the Fur family
HV325_RS17170	COG0583	DNA-binding transcription factor activity
HV325_RS17175	COG1053	succinate dehydrogenase
HV325_RS17205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS17205	COG2190	(PTS) system
HV325_RS17205	COG1263	PTS System
HV325_RS17215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV325_RS17220	COG1846	Transcriptional regulator
HV325_RS17220	COG1940	carbohydrate kinase activity
HV325_RS17225	COG0647	UMP catabolic process
HV325_RS17230	COG0367	asparagine synthase
HV325_RS17270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV325_RS17280	COG1702	phosphate starvation-inducible protein PhoH
HV325_RS17290	COG4535	Mg2 and Co2 transporter CorC
HV325_RS17305	COG0765	amino acid transport
HV325_RS17310	COG0765	amino acid transport
HV325_RS17315	COG1126	abc transporter atp-binding protein
HV325_RS17325	COG2888	peptidyl-tyrosine sulfation
HV325_RS17340	COG1466	dna polymerase III delta subunit
HV325_RS17350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV325_RS17360	COG0799	negative regulation of ribosome biogenesis
HV325_RS17370	COG0768	penicillin binding
HV325_RS17375	COG0772	Belongs to the SEDS family
HV325_RS17380	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV325_RS17385	COG1686	Belongs to the peptidase S11 family
HV325_RS17410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV325_RS17430	COG3069	C4-dicarboxylate transmembrane transporter activity
HV325_RS17435	COG4565	transcriptional regulatory protein
HV325_RS17440	COG3290	protein histidine kinase activity
HV325_RS17445	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV325_RS17455	COG2301	Belongs to the HpcH HpaI aldolase family
HV325_RS17460	COG3051	citrate lyase alpha subunit
HV325_RS17475	COG0471	metal ion transport
HV325_RS17480	COG3719	Belongs to the RNase T2 family
HV325_RS17495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV325_RS17515	COG0243	molybdopterin cofactor binding
HV325_RS17525	COG3634	alkyl hydroperoxide reductase activity
HV325_RS17535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV325_RS17540	COG0583	DNA-binding transcription factor activity
HV325_RS17545	COG3969	phosphoadenosine phosphosulfate
HV325_RS17550	COG1475	DNA binding
HV325_RS17555	COG0436	Aminotransferase
HV325_RS17560	COG0371	Dehydrogenase
HV325_RS17565	COG2879	small protein
HV325_RS17570	COG1966	Carbon starvation protein
HV325_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS17585	COG1535	isochorismatase
HV325_RS17585	COG3433	isochorismatase activity
HV325_RS17590	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV325_RS17595	COG1169	isochorismate synthase
HV325_RS17600	COG4592	Periplasmic binding protein
HV325_RS17610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV325_RS17615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV325_RS17620	COG1120	ATPase activity
HV325_RS17625	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV325_RS17630	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV325_RS17630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV325_RS17635	COG3251	PFAM MbtH domain protein
HV325_RS17640	COG2382	esterase
HV325_RS17645	COG4771	TonB-dependent receptor
HV325_RS17685	COG2315	Protein conserved in bacteria
HV325_RS17695	COG0668	transmembrane transport
HV325_RS17715	COG2211	Major facilitator Superfamily
HV325_RS17720	COG1113	amino acid transport
HV325_RS17780	COG3539	Fimbrial protein
HV325_RS17790	COG2501	S4 domain
HV325_RS17795	COG1988	membrane-bound metal-dependent
HV325_RS17805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV325_RS17815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV325_RS17820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV325_RS17840	COG1464	Belongs to the NlpA lipoprotein family
HV325_RS17845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV325_RS17850	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV325_RS17855	COG4181	ATPase activity
HV325_RS17860	COG2755	lipolytic protein G-D-S-L family
HV325_RS17865	COG0300	oxidoreductase activity
HV325_RS17870	COG3118	belongs to the thioredoxin family
HV325_RS17875	COG0390	transport system, permease component
HV325_RS17880	COG4619	ABC transporter
HV325_RS17885	COG0330	HflC and HflK could
HV325_RS17890	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV325_RS17910	COG4771	TonB-dependent receptor
HV325_RS17915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV325_RS17925	COG3721	Heme iron utilization protein
HV325_RS17935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV325_RS17950	COG3735	TraB family
HV325_RS17955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV325_RS17965	COG2223	nitrite transmembrane transporter activity
HV325_RS17970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV325_RS17970	COG4651	solute:proton antiporter activity
HV325_RS17975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV325_RS18020	COG2832	Protein of unknown function (DUF454)
HV325_RS18025	COG3923	Primosomal replication protein n
HV325_RS18035	COG1196	nuclear chromosome segregation
HV325_RS18035	COG3264	Mechanosensitive ion channel
HV325_RS18040	COG1309	transcriptional regulator
HV325_RS18045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV325_RS18050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV325_RS18065	COG0110	maltose O-acetyltransferase activity
HV325_RS18085	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV325_RS18090	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV325_RS18095	COG2364	Membrane
HV325_RS18100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV325_RS18120	COG3695	enzyme binding
HV325_RS18125	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV325_RS18130	COG1946	Acyl-CoA thioesterase
HV325_RS18135	COG0004	ammonium transporteR
HV325_RS18140	COG0347	Belongs to the P(II) protein family
HV325_RS18145	COG1132	(ABC) transporter
HV325_RS18150	COG1132	(ABC) transporter
HV325_RS18155	COG1522	sequence-specific DNA binding
HV325_RS18170	COG4533	DNA binding
HV325_RS18180	COG0824	Thioesterase
HV325_RS18185	COG1555	photosystem II stabilization
HV325_RS18190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV325_RS18195	COG0776	regulation of translation
HV325_RS18200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV325_RS18220	COG0271	Belongs to the BolA IbaG family
HV325_RS18225	COG3056	Lipoprotein
HV325_RS18230	COG2223	nitrite transmembrane transporter activity
HV325_RS18235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV325_RS18240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV325_RS18245	COG1845	cytochrome c oxidase, subunit III
HV325_RS18250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV325_RS18260	COG2814	Major facilitator Superfamily
HV325_RS18295	COG0142	geranyltranstransferase activity
HV325_RS18305	COG0667	Aldo Keto reductase
HV325_RS18310	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV325_RS18315	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV325_RS18330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV325_RS18330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV325_RS18340	COG4238	major outer membrane lipoprotein
HV325_RS18360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV325_RS18365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV325_RS18370	COG1862	Preprotein translocase
HV325_RS18380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV325_RS18390	COG0450	alkyl hydroperoxide reductase
HV325_RS18395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV325_RS18405	COG1335	isochorismatase
HV325_RS18410	COG0583	DNA-binding transcription factor activity
HV325_RS18415	COG0366	Alpha amylase catalytic
HV325_RS18430	COG5002	protein histidine kinase activity
HV325_RS18440	COG0420	3'-5' exonuclease activity
HV325_RS18445	COG0419	ATPase involved in DNA repair
HV325_RS18450	COG2814	Major facilitator Superfamily
HV325_RS18455	COG1940	carbohydrate kinase activity
HV325_RS18470	COG4126	flavin adenine dinucleotide binding
HV325_RS18490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV325_RS18495	COG3706	GGDEF domain
HV325_RS18505	COG1785	Belongs to the alkaline phosphatase family
HV325_RS18520	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV325_RS18540	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV325_RS18545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV325_RS18550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV325_RS18560	COG0113	porphobilinogen synthase activity
HV325_RS18565	COG2175	clavaminate synthase activity
HV325_RS18570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV325_RS18575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV325_RS18580	COG4521	taurine ABC transporter
HV325_RS18595	COG2271	Major facilitator Superfamily
HV325_RS18600	COG1840	ABC-type Fe3 transport system, periplasmic component
HV325_RS18610	COG3842	ATPase activity
HV325_RS18615	COG2040	homocysteine
HV325_RS18620	COG0833	amino acid
HV325_RS18625	COG2814	Major facilitator Superfamily
HV325_RS18660	COG1414	Transcriptional regulator
HV325_RS18690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV325_RS18705	COG1609	Transcriptional regulator
HV325_RS18730	COG2079	MmgE PrpD family protein
HV325_RS18735	COG0372	Belongs to the citrate synthase family
HV325_RS18745	COG3829	transcription factor binding
HV325_RS18755	COG1280	lysine exporter protein (LysE YggA)
HV325_RS18760	COG3706	GGDEF domain
HV325_RS18765	COG0348	domain, Protein
HV325_RS18785	COG0583	DNA-binding transcription factor activity
HV325_RS18810	COG3069	C4-dicarboxylate transmembrane transporter activity
HV325_RS18815	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV325_RS18825	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV325_RS18830	COG0693	protein deglycase activity
HV325_RS18835	COG2957	Belongs to the agmatine deiminase family
HV325_RS18840	COG2200	EAL domain
HV325_RS18845	COG0531	amino acid
HV325_RS18850	COG0174	glutamine synthetase
HV325_RS18855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV325_RS18860	COG1917	Cupin 2, conserved barrel domain protein
HV325_RS18860	COG1396	sequence-specific DNA binding
HV325_RS18865	COG1012	belongs to the aldehyde dehydrogenase family
HV325_RS18870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV325_RS18885	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HV325_RS18890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV325_RS18895	COG1999	signal sequence binding
HV325_RS18900	COG1773	rubredoxin
HV325_RS18905	COG1271	oxidase subunit
HV325_RS18910	COG1294	oxidase, subunit
HV325_RS18935	COG1609	Transcriptional regulator
HV325_RS18940	COG1757	Na H antiporter
HV325_RS18945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV325_RS19005	COG0582	viral genome integration into host DNA
HV325_RS19020	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV325_RS19060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV325_RS19070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV325_RS19095	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV325_RS19115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HV325_RS19120	COG1191	sigma factor activity
HV325_RS19145	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV325_RS19150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV325_RS19170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV325_RS19175	COG1256	bacterial-type flagellum assembly
HV325_RS19175	COG4786	Flagellar basal body rod
HV325_RS19200	COG4787	bacterial-type flagellum-dependent cell motility
HV325_RS19215	COG1558	bacterial-type flagellum-dependent cell motility
HV325_RS19260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV325_RS19280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV325_RS19290	COG1677	Flagellar hook-basal body complex protein FliE
HV325_RS19315	COG1987	bacterial-type flagellum assembly
HV325_RS19320	COG1684	flagellar biosynthetic protein fliR
HV325_RS19335	COG0791	NLP P60 protein
HV325_RS19340	COG3034	peptidoglycan biosynthetic process
HV325_RS19345	COG0121	glutamine amidotransferase
HV325_RS19355	COG1960	acyl-CoA dehydrogenase activity
HV325_RS19360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV325_RS19370	COG2200	EAL domain
HV325_RS19385	COG3539	Fimbrial protein
HV325_RS19395	COG3121	Chaperone
HV325_RS19400	COG3188	usher protein
HV325_RS19410	COG3539	Fimbrial protein
HV325_RS19415	COG0745	RESPONSE REGULATOR receiver
HV325_RS19430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV325_RS19440	COG2226	methyltransferase
HV325_RS19450	COG1388	LysM domain
HV325_RS19450	COG0741	lytic transglycosylase activity
HV325_RS19455	COG2226	methyltransferase
HV325_RS19465	COG2814	Major facilitator Superfamily
HV325_RS19470	COG0583	DNA-binding transcription factor activity
HV325_RS19505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV325_RS19515	COG2011	ABC-type metal ion transport system permease component
HV325_RS19520	COG1464	Belongs to the NlpA lipoprotein family
HV325_RS19530	COG1720	tRNA m6t6A37 methyltransferase activity
HV325_RS19540	COG3015	lipoprotein NlpE involved in copper resistance
HV325_RS19545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV325_RS19560	COG4568	rho-dependent transcription termination
HV325_RS19570	COG0346	lactoylglutathione lyase activity
HV325_RS19610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV325_RS19615	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV325_RS19630	COG0575	Belongs to the CDS family
HV325_RS19640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV325_RS19685	COG3835	regulator
HV325_RS19710	COG2860	membrane
HV325_RS19735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV325_RS19740	COG1120	ATPase activity
HV325_RS19745	COG4774	siderophore transport
HV325_RS19750	COG3539	Fimbrial protein
HV325_RS19755	COG3188	usher protein
HV325_RS19760	COG3121	Chaperone
HV325_RS19770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV325_RS19775	COG1643	Atp-dependent helicase
HV325_RS19780	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV325_RS19800	COG0617	tRNA 3'-terminal CCA addition
HV325_RS19805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV325_RS19810	COG3539	Fimbrial protein
HV325_RS19815	COG3121	Chaperone
HV325_RS19820	COG3188	usher protein
HV325_RS19835	COG3539	Fimbrial protein
HV325_RS19865	COG3121	Chaperone
HV325_RS19870	COG3188	usher protein
HV325_RS19890	COG0726	polysaccharide deacetylase
HV325_RS19895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS19900	COG0842	Transport permease protein
HV325_RS19905	COG1131	(ABC) transporter
HV325_RS19910	COG0288	reversible hydration of carbon dioxide
HV325_RS19915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV325_RS19945	COG3064	Membrane
HV325_RS19960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV325_RS19965	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV325_RS19970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV325_RS19985	COG2211	Major facilitator Superfamily
HV325_RS19990	COG3940	Belongs to the glycosyl hydrolase 43 family
HV325_RS19995	COG3725	Membrane protein required for beta-lactamase induction
HV325_RS20010	COG4969	Belongs to the N-Me-Phe pilin family
HV325_RS20015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV325_RS20020	COG1459	type II secretion system
HV325_RS20030	COG0237	dephospho-CoA kinase activity
HV325_RS20045	COG0494	nUDIX hydrolase
HV325_RS20065	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV325_RS20070	COG0849	cell division
HV325_RS20080	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV325_RS20095	COG0772	Belongs to the SEDS family
HV325_RS20100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV325_RS20110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV325_RS20115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV325_RS20120	COG0768	penicillin binding
HV325_RS20150	COG0028	Belongs to the TPP enzyme family
HV325_RS20185	COG1609	Transcriptional regulator
HV325_RS20195	COG1028	Short-chain dehydrogenase reductase Sdr
HV325_RS20200	COG2814	Major facilitator Superfamily
HV325_RS20220	COG1178	ABC-type Fe3 transport system permease component
HV325_RS20230	COG0586	Pfam SNARE associated Golgi protein
HV325_RS20250	COG0235	Class ii aldolase
HV325_RS20260	COG0417	DNA replication proofreading
HV325_RS20270	COG0564	pseudouridine synthase activity
HV325_RS20280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV325_RS20330	COG2271	Major facilitator Superfamily
HV325_RS20340	COG0644	oxidoreductase
HV325_RS20395	COG0505	Belongs to the CarA family
HV325_RS20415	COG1047	Peptidyl-prolyl cis-trans
HV325_RS20430	COG0196	riboflavin kinase activity
HV325_RS20450	COG0583	DNA-binding transcription factor activity
HV325_RS20465	COG0443	Heat shock 70 kDa protein
HV325_RS20475	COG4735	regulation of single-species biofilm formation
HV325_RS20480	COG1584	GPR1 FUN34 yaaH family protein
HV325_RS20490	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV325_RS20500	COG1115	amino acid carrier protein
HV325_RS20510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV325_RS20520	COG0460	homoserine dehydrogenase
HV325_RS20520	COG0527	aspartate kinase activity
HV325_RS20530	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV325_RS20540	COG0745	RESPONSE REGULATOR receiver
HV325_RS20545	COG4452	Inner membrane protein CreD
HV325_RS20550	COG2205	protein histidine kinase activity
HV325_RS20555	COG0745	RESPONSE REGULATOR receiver
HV325_RS20560	COG3045	CreA protein
HV325_RS20565	COG3708	Transcriptional regulator
HV325_RS20565	COG2207	Transcriptional regulator
HV325_RS20585	COG0741	lytic transglycosylase activity
HV325_RS20590	COG0488	(ABC) transporter
HV325_RS20605	COG0560	Phosphoserine phosphatase
HV325_RS20610	COG3726	membrane protein affecting hemolysin expression
HV325_RS20640	COG1328	CTP reductase activity
HV325_RS20645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV325_RS20650	COG0084	hydrolase, TatD family'
HV325_RS20655	COG4667	esterase of the alpha-beta hydrolase superfamily
HV325_RS20660	COG5487	UPF0391 membrane protein
HV325_RS20665	COG2823	Periplasmic or secreted lipoprotein
HV325_RS20675	COG1011	Hydrolase
HV325_RS20680	COG0456	acetyltransferase
HV325_RS20685	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV325_RS20715	COG3706	GGDEF domain
HV325_RS20720	COG4114	ferric iron reductase
HV325_RS20725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV325_RS20730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV325_RS20735	COG2197	response regulator
HV325_RS20740	COG2197	response regulator
HV325_RS20745	COG2966	Psort location CytoplasmicMembrane, score
HV325_RS20760	COG1484	DNA-dependent DNA replication
HV325_RS20780	COG1063	alcohol dehydrogenase
HV325_RS20785	COG1802	Transcriptional regulator
HV325_RS20790	COG2271	Major facilitator Superfamily
HV325_RS20800	COG0840	transmembrane signaling receptor activity
HV325_RS20805	COG1966	Carbon starvation protein
HV325_RS20810	COG2879	small protein
HV325_RS20815	COG0523	cobalamin synthesis protein
HV325_RS20825	COG1566	PFAM secretion protein HlyD family protein
HV325_RS20835	COG5457	Domain of unknown function (DUF1127)
HV325_RS20840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV325_RS20845	COG5464	transposase or invertase
HV325_RS20865	COG0626	cystathionine gamma-synthase activity
HV325_RS20870	COG1301	dicarboxylic acid transport
HV325_RS20875	COG0583	DNA-binding transcription factor activity
HV325_RS20880	COG2733	membrane
HV325_RS20890	COG0477	Major facilitator Superfamily
HV325_RS20900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV325_RS20910	COG2186	Transcriptional regulator
HV325_RS20915	COG0246	Mannitol dehydrogenase
HV325_RS20925	COG2610	gluconate transmembrane transporter activity
HV325_RS20930	COG1556	Lactate utilization protein
HV325_RS20935	COG1139	Iron-sulfur cluster binding protein
HV325_RS20940	COG0247	lactate metabolic process
HV325_RS20945	COG1620	l-lactate permease
HV325_RS21060	COG4974	Belongs to the 'phage' integrase family
HV325_RS21075	COG0582	viral genome integration into host DNA
HV325_RS21085	COG1064	alcohol dehydrogenase
HV325_RS21090	COG0433	COG0433 Predicted ATPase
HV325_RS21095	COG0795	lipopolysaccharide-transporting ATPase activity
HV325_RS21100	COG0795	lipopolysaccharide-transporting ATPase activity
HV325_RS21110	COG2927	DNA polymerase III (CHI subunit)
HV325_RS21115	COG0525	valine-tRNA ligase activity
HV325_RS21145	COG2731	YhcH YjgK YiaL family protein
HV325_RS21150	COG2235	arginine
HV325_RS21160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV325_RS21165	COG1288	antiporter activity
HV325_RS21170	COG1438	arginine binding
HV325_RS21215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV325_RS21230	COG1263	PTS System
HV325_RS21230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV325_RS21235	COG0366	Alpha amylase catalytic
HV325_RS21245	COG1737	Transcriptional regulator
HV325_RS21250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS21255	COG0383	alpha-mannosidase activity
HV325_RS21260	COG0366	Alpha amylase catalytic
HV325_RS21265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS21265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS21265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS21280	COG2026	Addiction module toxin, RelE StbE family
HV325_RS21285	COG3077	Addiction module antitoxin, RelB DinJ family
HV325_RS21290	COG3711	transcriptional antiterminator
HV325_RS21290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS21305	COG3964	amidohydrolase
HV325_RS21340	COG0312	modulator of DNA gyrase
HV325_RS21350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV325_RS21360	COG0840	transmembrane signaling receptor activity
HV325_RS21365	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS21370	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS21375	COG1129	ABC transporter
HV325_RS21380	COG1879	ABC-type sugar transport system periplasmic component
HV325_RS21390	COG2105	PFAM AIG2 family protein
HV325_RS21395	COG2911	Protein conserved in bacteria
HV325_RS21400	COG0729	surface antigen
HV325_RS21410	COG1609	Transcriptional regulator
HV325_RS21415	COG0673	inositol 2-dehydrogenase activity
HV325_RS21420	COG0673	inositol 2-dehydrogenase activity
HV325_RS21435	COG2211	Major facilitator Superfamily
HV325_RS21445	COG1253	flavin adenine dinucleotide binding
HV325_RS21455	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV325_RS21460	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV325_RS21470	COG1733	regulation of RNA biosynthetic process
HV325_RS21475	COG0702	epimerase
HV325_RS21485	COG0697	spore germination
HV325_RS21490	COG0840	transmembrane signaling receptor activity
HV325_RS21500	COG1113	amino acid transport
HV325_RS21505	COG0545	Peptidyl-prolyl cis-trans isomerase
HV325_RS21510	COG3061	Opacity-associated protein A
HV325_RS21525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV325_RS21540	COG0730	response to heat
HV325_RS21590	COG1073	alpha beta
HV325_RS21595	COG3650	response to hydrogen peroxide
HV325_RS21605	COG1960	acyl-CoA dehydrogenase activity
HV325_RS21610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV325_RS21615	COG0557	exoribonuclease II activity
HV325_RS21630	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV325_RS21635	COG0330	HflC and HflK could
HV325_RS21640	COG0330	HflC and HflK could
HV325_RS21645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV325_RS21650	COG1923	regulation of RNA biosynthetic process
HV325_RS21665	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV325_RS21670	COG0802	atpase or kinase
HV325_RS21675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV325_RS21675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV325_RS21680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV325_RS21715	COG3264	Mechanosensitive ion channel
HV325_RS21715	COG1511	domain protein
HV325_RS21730	COG1053	succinate dehydrogenase
HV325_RS21735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV325_RS21790	COG1509	lysine 2,3-aminomutase activity
HV325_RS21815	COG0531	amino acid
HV325_RS21820	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV325_RS21825	COG1027	Aspartate ammonia-lyase
HV325_RS21830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV325_RS21845	COG1309	transcriptional regulator
HV325_RS21855	COG0318	PFAM AMP-dependent synthetase and ligase
HV325_RS21885	COG3290	protein histidine kinase activity
HV325_RS21890	COG4565	transcriptional regulatory protein
HV325_RS21895	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV325_RS21900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS21900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV325_RS21905	COG3647	Membrane
HV325_RS21915	COG2211	Major facilitator Superfamily
HV325_RS21920	COG1486	melibiose metabolic process
HV325_RS21925	COG2169	Transcriptional regulator
HV325_RS21930	COG1982	Orn Lys Arg decarboxylase major
HV325_RS21935	COG2207	Transcriptional regulator
HV325_RS21940	COG0531	amino acid
HV325_RS21980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV325_RS21985	COG2824	Alkylphosphonate utilization operon protein PhnA
HV325_RS21990	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV325_RS21995	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV325_RS22000	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV325_RS22005	COG3639	organic phosphonate transmembrane transporter activity
HV325_RS22010	COG2188	Transcriptional regulator
HV325_RS22015	COG3624	Phosphonate C-P lyase system protein PhnG
HV325_RS22020	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV325_RS22025	COG3626	phosphonate metabolism
HV325_RS22030	COG3627	carbon phosphorus lyase activity
HV325_RS22035	COG4107	phosphonate C-P lyase system protein PhnK
HV325_RS22040	COG4778	phosphonate C-P lyase system protein PhnL
HV325_RS22045	COG3454	Phosphonate metabolism
HV325_RS22055	COG0456	acetyltransferase
HV325_RS22060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV325_RS22075	COG1129	ABC transporter
HV325_RS22080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS22105	COG0745	RESPONSE REGULATOR receiver
HV325_RS22110	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV325_RS22120	COG1566	PFAM secretion protein HlyD family protein
HV325_RS22125	COG1289	transmembrane transporter activity
HV325_RS22130	COG1538	Outer membrane efflux protein
HV325_RS22140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV325_RS22145	COG1301	dicarboxylic acid transport
HV325_RS22150	COG4235	cytochrome complex assembly
HV325_RS22155	COG3088	subunit of a heme lyase
HV325_RS22175	COG3301	Polysulphide reductase, NrfD
HV325_RS22180	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS22185	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV325_RS22200	COG3162	membrane
HV325_RS22210	COG1346	cytolysis
HV325_RS22215	COG1380	Effector of murein hydrolase LrgA
HV325_RS22220	COG0583	DNA-binding transcription factor activity
HV325_RS22225	COG0025	NhaP-type Na H and K H
HV325_RS22230	COG2252	PERMEase
HV325_RS22245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV325_RS22255	COG0629	single-stranded DNA binding
HV325_RS22260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV325_RS22265	COG2315	Protein conserved in bacteria
HV325_RS22270	COG3700	Belongs to the class B bacterial acid phosphatase family
HV325_RS22275	COG1448	Aminotransferase
HV325_RS22285	COG0305	Participates in initiation and elongation during chromosome replication
HV325_RS22300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV325_RS22310	COG0735	belongs to the Fur family
HV325_RS22315	COG3237	CsbD-like
HV325_RS22320	COG0534	Mate efflux family protein
HV325_RS22330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV325_RS22365	COG2182	Extracellular solute-binding protein
HV325_RS22380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV325_RS22385	COG1757	Na H antiporter
HV325_RS22390	COG3223	Belongs to the PsiE family
HV325_RS22395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV325_RS22400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV325_RS22425	COG0527	aspartate kinase activity
HV325_RS22430	COG3541	Predicted nucleotidyltransferase
HV325_RS22440	COG4650	regulator
HV325_RS22450	COG3039	Transposase
HV325_RS22465	COG1187	pseudouridine synthase activity
HV325_RS22505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV325_RS22520	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV325_RS22545	COG0646	methionine synthase
HV325_RS22545	COG1410	methionine synthase
HV325_RS22555	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV325_RS22565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV325_RS22575	COG0456	acetyltransferase
HV325_RS22600	COG0151	Belongs to the GarS family
HV325_RS22610	COG4191	Histidine kinase
HV325_RS22670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV325_RS22675	COG2104	thiamine diphosphate biosynthetic process
HV325_RS22690	COG1278	Cold shock
HV325_RS22700	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV325_RS22735	COG0250	Participates in transcription elongation, termination and antitermination
HV325_RS22780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV325_RS22840	COG0583	DNA-binding transcription factor activity
HV325_RS22875	COG2207	Transcriptional regulator
HV325_RS22885	COG0371	Dehydrogenase
HV325_RS22895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV325_RS22900	COG0583	DNA-binding transcription factor activity
HV325_RS22910	COG0737	Belongs to the 5'-nucleotidase family
HV325_RS22920	COG0460	homoserine dehydrogenase
HV325_RS22920	COG0527	aspartate kinase activity
HV325_RS22925	COG0626	cystathionine gamma-synthase activity
HV325_RS22935	COG2211	Major facilitator Superfamily
HV325_RS22950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV325_RS22955	COG1609	Transcriptional regulator
HV325_RS22960	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV325_RS22975	COG1575	Belongs to the MenA family. Type 1 subfamily
HV325_RS22990	COG3074	FtsZ-dependent cytokinesis
HV325_RS22995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV325_RS23005	COG1494	fructose-1,6-bisphosphatase
HV325_RS23015	COG3152	Membrane
HV325_RS23030	COG0471	metal ion transport
HV325_RS23060	COG3678	ATP-independent chaperone mediated protein folding
HV325_RS23065	COG0745	RESPONSE REGULATOR receiver
HV325_RS23070	COG2205	protein histidine kinase activity
HV325_RS23075	COG2258	MOSC domain
HV325_RS23080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV325_RS23125	COG1454	alcohol dehydrogenase
HV325_RS23140	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV325_RS23150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS23155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS23155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV325_RS23160	COG1363	Peptidase, m42
HV325_RS23165	COG3711	transcriptional antiterminator
HV325_RS23165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV325_RS23195	COG0437	4 iron, 4 sulfur cluster binding
HV325_RS23200	COG2864	formate dehydrogenase
HV325_RS23215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV325_RS23225	COG0456	acetyltransferase
HV325_RS23230	COG1490	D-aminoacyl-tRNA deacylase activity
HV325_RS23240	COG1011	Hydrolase
HV325_RS23245	COG1349	DNA-binding transcription factor activity
HV325_RS23260	COG3684	Belongs to the aldolase LacD family
HV325_RS23270	COG2017	converts alpha-aldose to the beta-anomer
HV325_RS23275	COG1501	Belongs to the glycosyl hydrolase 31 family
HV325_RS23305	COG3852	Histidine kinase
HV325_RS23310	COG2204	response regulator
HV325_RS23320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV325_RS23340	COG0204	Acyl-transferase
HV325_RS23355	COG3084	Protein conserved in bacteria
HV325_RS23360	COG0746	molybdenum cofactor guanylyltransferase activity
HV325_RS23365	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV325_RS23405	COG1739	Uncharacterized protein family UPF0029
HV325_RS23425	COG1609	Transcriptional regulator
HV325_RS23430	COG1940	carbohydrate kinase activity
HV325_RS23455	COG0805	protein transport
HV325_RS23505	COG0583	DNA-binding transcription factor activity
HV325_RS23510	COG0697	spore germination
HV325_RS23515	COG0561	phosphatase activity
HV325_RS23520	COG2267	carboxylic ester hydrolase activity
HV325_RS23525	COG1280	lysine exporter protein (LysE YggA)
HV325_RS23535	COG1280	lysine exporter protein (LysE YggA)
HV325_RS23570	COG1011	Hydrolase
HV325_RS23615	COG2959	enzyme of heme biosynthesis
HV325_RS23620	COG3071	HemY protein
HV325_RS23665	COG2244	polysaccharide biosynthetic process
HV325_RS23670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV325_RS23675	COG0456	acetyltransferase
HV325_RS23680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV325_RS23695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV325_RS23700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV325_RS23710	COG3118	belongs to the thioredoxin family
HV325_RS23730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV325_RS23750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV325_RS23760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV325_RS23765	COG3978	acetolactate synthase activity
HV325_RS23785	COG3085	chromosome segregation
HV325_RS23825	COG2186	Transcriptional regulator
HV325_RS23830	COG0477	Major facilitator Superfamily
HV325_RS23835	COG1609	Transcriptional regulator
HV325_RS23840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV325_RS23845	COG1879	ABC-type sugar transport system periplasmic component
HV325_RS23850	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV325_RS23860	COG1869	D-ribose catabolic process
HV325_RS23885	COG1522	sequence-specific DNA binding
HV325_RS23890	COG0716	FMN binding
HV325_RS23905	COG3312	ion transport
HV325_RS23930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV325_RS23940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV325_RS23945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV325_RS23965	COG3121	Chaperone
HV325_RS23975	COG3539	Fimbrial protein
HV325_RS23980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV325_RS23985	COG0573	inorganic phosphate transmembrane transporter activity
HV325_RS23990	COG0581	inorganic phosphate transmembrane transporter activity
HV325_RS24000	COG0704	Plays a role in the regulation of phosphate uptake
HV325_RS24005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV325_RS24010	COG2252	PERMEase
HV325_RS24015	COG0431	NADPH-dependent FMN reductase
HV325_RS24020	COG2091	lysine biosynthetic process via aminoadipic acid
HV325_RS24055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV325_RS24115	COG4644	lycopene metabolic process
HV325_RS24130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV325_RS24155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV325_RS24160	COG1127	ABC transporter
HV325_RS24215	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS24240	COG1802	Transcriptional regulator
HV325_RS24295	COG2974	May be involved in recombination
HV325_RS24300	COG3039	Transposase
HV325_RS24460	COG3423	Transcriptional regulator
HV325_RS24475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV325_RS24480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV325_RS24515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV325_RS24520	COG0501	Belongs to the peptidase M48B family
HV325_RS24580	COG0542	response to heat
HV325_RS24585	COG0071	Belongs to the small heat shock protein (HSP20) family
HV325_RS24655	COG2826	transposase and inactivated derivatives, IS30 family
HV325_RS24670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV325_RS24700	COG0789	Transcriptional regulator
HV325_RS24720	COG3039	Transposase
HV325_RS24755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV325_RS24785	COG3039	Transposase
HV325_RS24790	COG1528	Iron-storage protein
HV325_RS24830	COG5654	RES domain protein
HV325_RS24835	COG5642	Protein of unknown function (DUF2384)
HV325_RS24880	COG1192	Involved in chromosome partitioning
HV325_RS24935	COG0305	Participates in initiation and elongation during chromosome replication
HV325_RS24980	COG2801	Transposase and inactivated derivatives
HV325_RS24985	COG3547	Transposase (IS116 IS110 IS902 family)
HV325_RS24995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HV325_RS25000	COG3077	Addiction module antitoxin, RelB DinJ family
HV325_RS25005	COG2026	Addiction module toxin, RelE StbE family
HV325_RS25075	COG0659	secondary active sulfate transmembrane transporter activity
HV325_RS25080	COG0589	response to stress
HV325_RS25085	COG1442	glycosyl transferase family 8
HV325_RS25085	COG1216	Glycosyl transferase, family 2