locus-tag	class	description
GUC46_RS00010	COG0592	DNA-directed DNA polymerase activity
GUC46_RS00020	COG0187	DNA topoisomerase II activity
GUC46_RS00025	COG0561	phosphatase activity
GUC46_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
GUC46_RS00040	COG5645	(Lipo)protein
GUC46_RS00060	COG2149	membrane
GUC46_RS00070	COG0641	radical SAM
GUC46_RS00080	COG2610	gluconate transmembrane transporter activity
GUC46_RS00085	COG0583	DNA-binding transcription factor activity
GUC46_RS00095	COG2814	Major facilitator Superfamily
GUC46_RS00115	COG0028	Belongs to the TPP enzyme family
GUC46_RS00120	COG0440	acetolactate synthase activity
GUC46_RS00125	COG1349	DNA-binding transcription factor activity
GUC46_RS00130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS00135	COG0738	Major facilitator superfamily
GUC46_RS00145	COG2197	response regulator
GUC46_RS00175	COG3620	sequence-specific DNA binding
GUC46_RS00185	COG2723	6-phospho-beta-galactosidase activity
GUC46_RS00210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS00210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS00215	COG3715	PTS system
GUC46_RS00220	COG3716	PTS system mannose fructose sorbose family IID component
GUC46_RS00235	COG5464	transposase or invertase
GUC46_RS00240	COG1464	Belongs to the NlpA lipoprotein family
GUC46_RS00245	COG0697	spore germination
GUC46_RS00255	COG0604	alcohol dehydrogenase
GUC46_RS00260	COG0583	DNA-binding transcription factor activity
GUC46_RS00290	COG2197	response regulator
GUC46_RS00310	COG2771	luxR family
GUC46_RS00355	COG2211	Major facilitator Superfamily
GUC46_RS00360	COG1501	Belongs to the glycosyl hydrolase 31 family
GUC46_RS00365	COG3711	transcriptional antiterminator
GUC46_RS00370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS00370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS00370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS00375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS00380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS00380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS00390	COG0191	fructose-bisphosphate aldolase activity
GUC46_RS00400	COG2982	Protein involved in outer membrane biogenesis
GUC46_RS00405	COG2233	PERMEase
GUC46_RS00410	COG0786	glutamate:sodium symporter activity
GUC46_RS00415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GUC46_RS00420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GUC46_RS00425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GUC46_RS00445	COG2860	membrane
GUC46_RS00450	COG1561	YicC-like family, N-terminal region
GUC46_RS00475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GUC46_RS00505	COG1519	Transferase
GUC46_RS00510	COG0438	transferase activity, transferring glycosyl groups
GUC46_RS00515	COG0515	serine threonine protein kinase
GUC46_RS00520	COG1442	glycosyl transferase family 8
GUC46_RS00525	COG1442	glycosyl transferase family 8
GUC46_RS00535	COG0859	PFAM glycosyl transferase family 9
GUC46_RS00540	COG1215	transferase activity, transferring glycosyl groups
GUC46_RS00545	COG3307	-O-antigen
GUC46_RS00555	COG0859	PFAM glycosyl transferase family 9
GUC46_RS00565	COG0156	8-amino-7-oxononanoate synthase activity
GUC46_RS00575	COG1216	Glycosyl transferase, family 2
GUC46_RS00580	COG2861	carbohydrate metabolic process
GUC46_RS00585	COG4942	peptidase
GUC46_RS00595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GUC46_RS00600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GUC46_RS00615	COG1045	serine acetyltransferase
GUC46_RS00620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GUC46_RS00625	COG2271	Major facilitator Superfamily
GUC46_RS00635	COG2186	Transcriptional regulator
GUC46_RS00655	COG3722	fumarate hydratase activity
GUC46_RS00665	COG2213	PTS system mannitol-specific
GUC46_RS00665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS00675	COG1566	PFAM secretion protein HlyD family protein
GUC46_RS00690	COG3501	Rhs element vgr protein
GUC46_RS00720	COG0625	glutathione transferase activity
GUC46_RS00730	COG3276	selenocysteine insertion sequence binding
GUC46_RS00735	COG1454	alcohol dehydrogenase
GUC46_RS00740	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS00750	COG1566	PFAM secretion protein HlyD family protein
GUC46_RS00755	COG0583	DNA-binding transcription factor activity
GUC46_RS00760	COG3713	MltA-interacting MipA family protein
GUC46_RS00770	COG2211	Major facilitator Superfamily
GUC46_RS00775	COG4977	sequence-specific DNA binding
GUC46_RS00775	COG1917	Cupin 2, conserved barrel domain protein
GUC46_RS00780	COG0235	Class ii aldolase
GUC46_RS00785	COG3623	hexulose-6-phosphate isomerase
GUC46_RS00790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GUC46_RS00795	COG1070	Carbohydrate kinase
GUC46_RS00800	COG2271	Major facilitator Superfamily
GUC46_RS00810	COG2731	YhcH YjgK YiaL family protein
GUC46_RS00820	COG1414	Transcriptional regulator
GUC46_RS00825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUC46_RS00830	COG3977	Valine--pyruvate aminotransferase
GUC46_RS00835	COG0366	Alpha amylase catalytic
GUC46_RS00840	COG2992	FlgJ-related protein
GUC46_RS00845	COG2207	Transcriptional regulator
GUC46_RS00845	COG1609	Transcriptional regulator
GUC46_RS00855	COG1070	Carbohydrate kinase
GUC46_RS00860	COG4682	membrane
GUC46_RS00865	COG3274	enterobacterial common antigen metabolic process
GUC46_RS00890	COG1278	Cold shock
GUC46_RS00895	COG2944	sequence-specific DNA binding
GUC46_RS00910	COG2814	Major facilitator Superfamily
GUC46_RS00915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS00925	COG1609	Transcriptional regulator
GUC46_RS00930	COG2885	chlorophyll binding
GUC46_RS00935	COG0243	molybdopterin cofactor binding
GUC46_RS00940	COG0456	acetyltransferase
GUC46_RS00945	COG2818	Glycosylase
GUC46_RS00950	COG5571	outer membrane autotransporter
GUC46_RS00955	COG2223	nitrite transmembrane transporter activity
GUC46_RS00985	COG0747	negative chemotaxis
GUC46_RS00990	COG0601	transmembrane transport
GUC46_RS00995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GUC46_RS01000	COG0444	Belongs to the ABC transporter superfamily
GUC46_RS01005	COG4608	Belongs to the ABC transporter superfamily
GUC46_RS01010	COG2204	response regulator
GUC46_RS01015	COG0814	amino acid
GUC46_RS01030	COG2200	EAL domain
GUC46_RS01030	COG2199	diguanylate cyclase activity
GUC46_RS01045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS01050	COG2200	EAL domain
GUC46_RS01055	COG2982	Protein involved in outer membrane biogenesis
GUC46_RS01060	COG0477	Major facilitator Superfamily
GUC46_RS01065	COG1295	ribonuclease BN
GUC46_RS01070	COG0583	DNA-binding transcription factor activity
GUC46_RS01085	COG2200	EAL domain
GUC46_RS01090	COG2197	response regulator
GUC46_RS01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GUC46_RS01115	COG1858	cytochrome C peroxidase
GUC46_RS01125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUC46_RS01130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GUC46_RS01135	COG0339	signal peptide processing
GUC46_RS01150	COG1959	2 iron, 2 sulfur cluster binding
GUC46_RS01160	COG0589	response to stress
GUC46_RS01170	COG0306	phosphate transporter
GUC46_RS01175	COG2081	HI0933 family
GUC46_RS01180	COG2239	Acts as a magnesium transporter
GUC46_RS01185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS01190	COG1129	ABC transporter
GUC46_RS01190	COG0842	Transport permease protein
GUC46_RS01195	COG0842	Transport permease protein
GUC46_RS01205	COG2091	lysine biosynthetic process via aminoadipic acid
GUC46_RS01210	COG0628	permease
GUC46_RS01215	COG0477	Major facilitator Superfamily
GUC46_RS01225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GUC46_RS01240	COG3714	YhhN family
GUC46_RS01265	COG3776	membrane
GUC46_RS01270	COG0742	ribosomal rna small subunit methyltransferase
GUC46_RS01275	COG0552	protein localization to endoplasmic reticulum
GUC46_RS01280	COG2884	Cell division ATP-binding protein ftsE
GUC46_RS01285	COG2177	Part of the ABC transporter FtsEX involved in
GUC46_RS01305	COG0683	leucine binding
GUC46_RS01310	COG0559	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS01315	COG4177	L-phenylalanine transmembrane transporter activity
GUC46_RS01320	COG0411	ABC transporter
GUC46_RS01325	COG0410	ABC transporter
GUC46_RS01335	COG1653	transport
GUC46_RS01355	COG0584	glycerophosphoryl diester phosphodiesterase
GUC46_RS01365	COG0405	Gamma-glutamyltransferase
GUC46_RS01390	COG3157	Type VI secretion system effector, Hcp
GUC46_RS01400	COG1247	-acetyltransferase
GUC46_RS01405	COG0673	inositol 2-dehydrogenase activity
GUC46_RS01410	COG1741	Belongs to the pirin family
GUC46_RS01415	COG1609	Transcriptional regulator
GUC46_RS01420	COG3265	gluconokinase activity
GUC46_RS01425	COG2610	gluconate transmembrane transporter activity
GUC46_RS01440	COG2095	MarC family integral membrane protein
GUC46_RS01445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GUC46_RS01470	COG0058	SHG alpha-glucan phosphorylase activity
GUC46_RS01475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GUC46_RS01490	COG1349	DNA-binding transcription factor activity
GUC46_RS01500	COG0058	SHG alpha-glucan phosphorylase activity
GUC46_RS01505	COG1640	4-alpha-glucanotransferase
GUC46_RS01510	COG2610	gluconate transmembrane transporter activity
GUC46_RS01520	COG1040	competence protein
GUC46_RS01545	COG1918	ferrous iron import across plasma membrane
GUC46_RS01550	COG2183	response to ionizing radiation
GUC46_RS01555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GUC46_RS01560	COG0745	RESPONSE REGULATOR receiver
GUC46_RS01575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GUC46_RS01585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GUC46_RS01590	COG1011	Hydrolase
GUC46_RS01600	COG0494	nUDIX hydrolase
GUC46_RS01605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GUC46_RS01610	COG4972	Pilus assembly protein
GUC46_RS01615	COG3166	PFAM Fimbrial assembly family protein
GUC46_RS01630	COG4796	Type ii and iii secretion system protein
GUC46_RS01645	COG3266	domain, Protein
GUC46_RS01650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GUC46_RS01655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GUC46_RS01665	COG0180	Tryptophanyl-tRNA synthetase
GUC46_RS01670	COG2188	Transcriptional regulator
GUC46_RS01680	COG3457	Alanine racemase
GUC46_RS01685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GUC46_RS01690	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GUC46_RS01705	COG0626	cystathionine gamma-synthase activity
GUC46_RS01725	COG2146	nitrite reductase [NAD(P)H] activity
GUC46_RS01730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GUC46_RS01755	COG0512	Glutamine amidotransferase of anthranilate synthase
GUC46_RS01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GUC46_RS01765	COG1289	transmembrane transporter activity
GUC46_RS01775	COG1765	OsmC-like protein
GUC46_RS01780	COG3954	Phosphoribulokinase
GUC46_RS01790	COG0429	hydrolase of the alpha beta-hydrolase fold
GUC46_RS01800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GUC46_RS01810	COG0488	(ABC) transporter
GUC46_RS01825	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GUC46_RS01830	COG1047	Peptidyl-prolyl cis-trans
GUC46_RS01840	COG0545	Peptidyl-prolyl cis-trans isomerase
GUC46_RS01845	COG2964	Protein conserved in bacteria
GUC46_RS01870	COG0049	tRNA binding
GUC46_RS01885	COG2906	2 iron, 2 sulfur cluster binding
GUC46_RS01900	COG0051	transcription antitermination factor activity, RNA binding
GUC46_RS01910	COG0088	Forms part of the polypeptide exit tunnel
GUC46_RS01955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GUC46_RS02000	COG0200	Binds to the 23S rRNA
GUC46_RS02005	COG0201	protein transport
GUC46_RS02020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GUC46_RS02045	COG0789	Transcriptional regulator
GUC46_RS02050	COG3036	rescue of stalled ribosome
GUC46_RS02060	COG0569	domain protein
GUC46_RS02080	COG0758	DNA mediated transformation
GUC46_RS02090	COG0551	DNA topoisomerase type I activity
GUC46_RS02110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GUC46_RS02150	COG1126	abc transporter atp-binding protein
GUC46_RS02155	COG0765	amino acid transport
GUC46_RS02160	COG4597	amino acid ABC transporter
GUC46_RS02165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUC46_RS02175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUC46_RS02180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS02185	COG1309	transcriptional regulator
GUC46_RS02195	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GUC46_RS02205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GUC46_RS02220	COG4145	pantothenate transmembrane transporter activity
GUC46_RS02225	COG3924	membrane
GUC46_RS02230	COG0439	Biotin carboxylase
GUC46_RS02235	COG0511	ligase activity, forming carbon-carbon bonds
GUC46_RS02250	COG0604	alcohol dehydrogenase
GUC46_RS02255	COG2199	diguanylate cyclase activity
GUC46_RS02255	COG2200	EAL domain
GUC46_RS02265	COG1077	Cell shape determining protein MreB Mrl
GUC46_RS02270	COG1792	Involved in formation and maintenance of cell shape
GUC46_RS02275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GUC46_RS02285	COG1530	ribonuclease E activity
GUC46_RS02290	COG3164	Protein of unknown function
GUC46_RS02295	COG0312	modulator of DNA gyrase
GUC46_RS02300	COG0583	DNA-binding transcription factor activity
GUC46_RS02320	COG2732	(Barnase) inhibitor
GUC46_RS02340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GUC46_RS02345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GUC46_RS02350	COG3105	Protein conserved in bacteria
GUC46_RS02355	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GUC46_RS02370	COG0625	glutathione transferase activity
GUC46_RS02375	COG2969	positive regulation of protein catabolic process
GUC46_RS02380	COG3069	C4-dicarboxylate transmembrane transporter activity
GUC46_RS02405	COG2731	YhcH YjgK YiaL family protein
GUC46_RS02410	COG0402	S-adenosylhomocysteine deaminase activity
GUC46_RS02415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GUC46_RS02420	COG4804	nuclease activity
GUC46_RS02425	COG0493	'glutamate synthase
GUC46_RS02430	COG0067	glutamate synthase
GUC46_RS02430	COG0069	glutamate synthase activity
GUC46_RS02430	COG0070	glutamate synthase
GUC46_RS02435	COG1242	4 iron, 4 sulfur cluster binding
GUC46_RS02440	COG0784	Response regulator, receiver
GUC46_RS02440	COG5002	protein histidine kinase activity
GUC46_RS02440	COG2198	Histidine kinase
GUC46_RS02445	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GUC46_RS02455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS02465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS02470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GUC46_RS02480	COG1137	ATPase activity
GUC46_RS02485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GUC46_RS02490	COG3117	lipopolysaccharide transmembrane transporter activity
GUC46_RS02495	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GUC46_RS02505	COG0530	calcium, potassium:sodium antiporter activity
GUC46_RS02510	COG1127	ABC transporter
GUC46_RS02515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GUC46_RS02520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GUC46_RS02525	COG2854	intermembrane phospholipid transfer
GUC46_RS02530	COG3113	response to antibiotic
GUC46_RS02535	COG5007	Belongs to the BolA IbaG family
GUC46_RS02545	COG3423	Transcriptional regulator
GUC46_RS02550	COG0142	geranyltranstransferase activity
GUC46_RS02565	COG0697	spore germination
GUC46_RS02575	COG2027	D-alanyl-D-alanine carboxypeptidase
GUC46_RS02580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GUC46_RS02585	COG1534	Rna-binding protein
GUC46_RS02595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GUC46_RS02600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GUC46_RS02610	COG3069	C4-dicarboxylate transmembrane transporter activity
GUC46_RS02615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GUC46_RS02620	COG0583	DNA-binding transcription factor activity
GUC46_RS02625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GUC46_RS02650	COG0195	Participates in both transcription termination and antitermination
GUC46_RS02655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GUC46_RS02660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GUC46_RS02680	COG4785	May be involved in cell division
GUC46_RS02690	COG0513	Belongs to the DEAD box helicase family
GUC46_RS02695	COG0814	amino acid
GUC46_RS02700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GUC46_RS02720	COG3153	acetyltransferase
GUC46_RS02735	COG0702	epimerase
GUC46_RS02740	COG2823	Periplasmic or secreted lipoprotein
GUC46_RS02760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GUC46_RS02765	COG0436	Aminotransferase
GUC46_RS02770	COG1263	PTS System
GUC46_RS02770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS02780	COG2222	sugar isomerase
GUC46_RS02785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GUC46_RS02790	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS02795	COG3716	PTS system mannose fructose sorbose family IID component
GUC46_RS02805	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS02815	COG1349	DNA-binding transcription factor activity
GUC46_RS02820	COG1349	DNA-binding transcription factor activity
GUC46_RS02825	COG1940	carbohydrate kinase activity
GUC46_RS02835	COG3842	ATPase activity
GUC46_RS02840	COG0395	ABC-type sugar transport system, permease component
GUC46_RS02855	COG2721	sulfolactate sulfo-lyase activity
GUC46_RS02860	COG2271	Major facilitator Superfamily
GUC46_RS02870	COG2084	Dehydrogenase
GUC46_RS02875	COG1929	Belongs to the glycerate kinase type-1 family
GUC46_RS02885	COG0583	DNA-binding transcription factor activity
GUC46_RS02905	COG1882	Formate acetyltransferase
GUC46_RS02910	COG0251	oxidation-reduction process
GUC46_RS02915	COG1760	l-serine dehydratase
GUC46_RS02920	COG0814	amino acid
GUC46_RS02935	COG1741	Belongs to the pirin family
GUC46_RS02940	COG0583	DNA-binding transcription factor activity
GUC46_RS02945	COG3152	Membrane
GUC46_RS02950	COG0435	Glutathione S-transferase
GUC46_RS02955	COG2259	Doxx family
GUC46_RS02965	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
GUC46_RS02970	COG4575	ribosome binding
GUC46_RS02975	COG1422	Protein of unknown function (DUF1090)
GUC46_RS02985	COG0586	Pfam SNARE associated Golgi protein
GUC46_RS02990	COG2186	Transcriptional regulator
GUC46_RS02995	COG2271	Major facilitator Superfamily
GUC46_RS03005	COG2721	sulfolactate sulfo-lyase activity
GUC46_RS03025	COG0673	inositol 2-dehydrogenase activity
GUC46_RS03030	COG1451	nucleotide metabolic process
GUC46_RS03040	COG1902	pentaerythritol trinitrate reductase activity
GUC46_RS03040	COG0446	pyridine nucleotide-disulphide oxidoreductase
GUC46_RS03045	COG3408	Glycogen debranching enzyme
GUC46_RS03045	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GUC46_RS03055	COG0531	amino acid
GUC46_RS03060	COG2731	YhcH YjgK YiaL family protein
GUC46_RS03065	COG3250	beta-galactosidase activity
GUC46_RS03070	COG1609	Transcriptional regulator
GUC46_RS03075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GUC46_RS03085	COG0840	transmembrane signaling receptor activity
GUC46_RS03090	COG1695	Transcriptional regulator
GUC46_RS03095	COG2375	cellular response to nickel ion
GUC46_RS03105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GUC46_RS03180	COG4771	TonB-dependent receptor
GUC46_RS03185	COG3391	amine dehydrogenase activity
GUC46_RS03190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GUC46_RS03195	COG0358	DNA primase activity
GUC46_RS03205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GUC46_RS03210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GUC46_RS03220	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GUC46_RS03245	COG0471	metal ion transport
GUC46_RS03270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GUC46_RS03285	COG4991	sh3 domain protein
GUC46_RS03290	COG3025	triphosphatase activity
GUC46_RS03305	COG2268	Band 7 protein
GUC46_RS03310	COG1585	Membrane protein implicated in regulation of membrane protease activity
GUC46_RS03330	COG3539	Fimbrial protein
GUC46_RS03335	COG3121	Chaperone
GUC46_RS03340	COG3188	usher protein
GUC46_RS03345	COG3539	Fimbrial protein
GUC46_RS03370	COG3384	dioxygenase
GUC46_RS03375	COG0754	glutathionylspermidine amidase activity
GUC46_RS03390	COG0494	nUDIX hydrolase
GUC46_RS03395	COG3151	Protein conserved in bacteria
GUC46_RS03400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GUC46_RS03405	COG3150	esterase
GUC46_RS03410	COG0187	DNA topoisomerase II activity
GUC46_RS03415	COG4977	sequence-specific DNA binding
GUC46_RS03415	COG1917	Cupin 2, conserved barrel domain protein
GUC46_RS03425	COG2211	Major facilitator Superfamily
GUC46_RS03430	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GUC46_RS03435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GUC46_RS03440	COG2249	NAD(P)H dehydrogenase (quinone) activity
GUC46_RS03460	COG0745	RESPONSE REGULATOR receiver
GUC46_RS03465	COG3111	PFAM Bacterial OB fold (BOF) protein
GUC46_RS03475	COG0204	Acyl-transferase
GUC46_RS03480	COG2132	Multicopper oxidase
GUC46_RS03485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GUC46_RS03500	COG0471	metal ion transport
GUC46_RS03505	COG0656	L-ascorbic acid biosynthetic process
GUC46_RS03510	COG1979	alcohol dehydrogenase
GUC46_RS03515	COG2207	Transcriptional regulator
GUC46_RS03520	COG0586	Pfam SNARE associated Golgi protein
GUC46_RS03525	COG0626	cystathionine gamma-synthase activity
GUC46_RS03530	COG0811	peptide transport
GUC46_RS03535	COG0848	biopolymer transport protein
GUC46_RS03555	COG0667	Aldo Keto reductase
GUC46_RS03565	COG0840	transmembrane signaling receptor activity
GUC46_RS03575	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GUC46_RS03580	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS03585	COG5557	Pfam Polysulphide reductase, NrfD
GUC46_RS03590	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GUC46_RS03595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GUC46_RS03600	COG1773	rubredoxin
GUC46_RS03605	COG0375	protein maturation
GUC46_RS03610	COG0298	carbon dioxide binding
GUC46_RS03615	COG0625	glutathione transferase activity
GUC46_RS03620	COG0243	molybdopterin cofactor binding
GUC46_RS03625	COG0754	glutathionylspermidine amidase activity
GUC46_RS03655	COG3501	Rhs element vgr protein
GUC46_RS03735	COG3157	Type VI secretion system effector, Hcp
GUC46_RS03770	COG3209	COG3209 Rhs family protein
GUC46_RS03775	COG3501	Rhs element vgr protein
GUC46_RS03840	COG0582	viral genome integration into host DNA
GUC46_RS03850	COG1811	Na channel or pump
GUC46_RS03855	COG1982	Orn Lys Arg decarboxylase major
GUC46_RS03860	COG2211	Major facilitator Superfamily
GUC46_RS03875	COG1194	a g-specific adenine glycosylase
GUC46_RS03885	COG3171	Protein conserved in bacteria
GUC46_RS03895	COG0252	asparaginase activity
GUC46_RS03905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GUC46_RS03920	COG0762	integral membrane protein
GUC46_RS03925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GUC46_RS03930	COG2805	Type II/IV secretion system protein
GUC46_RS03945	COG0189	ligase activity
GUC46_RS03950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GUC46_RS03955	COG2356	endonuclease I
GUC46_RS03965	COG2814	Major facilitator Superfamily
GUC46_RS03985	COG1166	arginine decarboxylase activity
GUC46_RS03995	COG0501	Belongs to the peptidase M48B family
GUC46_RS04000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GUC46_RS04010	COG1122	ATPase activity
GUC46_RS04040	COG0191	fructose-bisphosphate aldolase activity
GUC46_RS04045	COG0668	transmembrane transport
GUC46_RS04050	COG1279	arginine transmembrane transporter activity
GUC46_RS04055	COG2968	Membrane
GUC46_RS04060	COG0583	DNA-binding transcription factor activity
GUC46_RS04065	COG0427	acetyl-CoA hydrolase
GUC46_RS04070	COG1024	Enoyl-CoA hydratase
GUC46_RS04075	COG1703	isobutyryl-CoA mutase activity
GUC46_RS04080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUC46_RS04080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUC46_RS04095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GUC46_RS04100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GUC46_RS04120	COG0006	proline dipeptidase activity
GUC46_RS04125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUC46_RS04130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUC46_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS04155	COG3501	Rhs element vgr protein
GUC46_RS04175	COG2723	6-phospho-beta-galactosidase activity
GUC46_RS04180	COG1737	Transcriptional regulator
GUC46_RS04190	COG1272	protein, Hemolysin III
GUC46_RS04200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GUC46_RS04210	COG0716	FMN binding
GUC46_RS04215	COG4974	Belongs to the 'phage' integrase family
GUC46_RS04225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GUC46_RS04245	COG4942	peptidase
GUC46_RS04335	COG0457	Tetratricopeptide repeat
GUC46_RS04340	COG0726	polysaccharide deacetylase
GUC46_RS04340	COG1649	PFAM Uncharacterised BCR, COG1649
GUC46_RS04345	COG1215	transferase activity, transferring glycosyl groups
GUC46_RS04355	COG3592	Divergent 4Fe-4S mono-cluster
GUC46_RS04360	COG2388	GCN5-related N-acetyl-transferase
GUC46_RS04365	COG0583	DNA-binding transcription factor activity
GUC46_RS04370	COG0666	response to abiotic stimulus
GUC46_RS04380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GUC46_RS04385	COG1304	FMN binding
GUC46_RS04395	COG0549	Belongs to the carbamate kinase family
GUC46_RS04400	COG0402	S-adenosylhomocysteine deaminase activity
GUC46_RS04415	COG0814	amino acid
GUC46_RS04430	COG0183	Belongs to the thiolase family
GUC46_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS04445	COG2814	Major facilitator Superfamily
GUC46_RS04455	COG1794	racemase activity, acting on amino acids and derivatives
GUC46_RS04460	COG0583	DNA-binding transcription factor activity
GUC46_RS04465	COG0019	diaminopimelate decarboxylase activity
GUC46_RS04470	COG1609	Transcriptional regulator
GUC46_RS04490	COG0667	Aldo Keto reductase
GUC46_RS04500	COG0861	Integral membrane protein TerC family
GUC46_RS04530	COG2165	general secretion pathway protein
GUC46_RS04535	COG4795	General secretion pathway protein
GUC46_RS04545	COG4967	type IV pilus modification protein PilV
GUC46_RS04550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GUC46_RS04560	COG1074	ATP-dependent DNA helicase activity
GUC46_RS04565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GUC46_RS04570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GUC46_RS04570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GUC46_RS04575	COG0860	N-Acetylmuramoyl-L-alanine amidase
GUC46_RS04595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GUC46_RS04600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GUC46_RS04605	COG2166	iron-sulfur cluster assembly
GUC46_RS04610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GUC46_RS04620	COG0583	DNA-binding transcription factor activity
GUC46_RS04625	COG2363	Small membrane protein
GUC46_RS04635	COG1349	DNA-binding transcription factor activity
GUC46_RS04645	COG1070	Carbohydrate kinase
GUC46_RS04655	COG1129	ABC transporter
GUC46_RS04660	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS04670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GUC46_RS04680	COG0235	Class ii aldolase
GUC46_RS04685	COG1454	alcohol dehydrogenase
GUC46_RS04695	COG1760	l-serine dehydratase
GUC46_RS04700	COG0814	amino acid
GUC46_RS04705	COG1611	Belongs to the LOG family
GUC46_RS04720	COG3098	single-species biofilm formation
GUC46_RS04725	COG0564	pseudouridine synthase activity
GUC46_RS04730	COG0716	FMN binding
GUC46_RS04735	COG2271	Major facilitator Superfamily
GUC46_RS04740	COG4948	Mandelate Racemase Muconate Lactonizing
GUC46_RS04745	COG4948	Mandelate Racemase Muconate Lactonizing
GUC46_RS04750	COG1929	Belongs to the glycerate kinase type-1 family
GUC46_RS04755	COG2205	protein histidine kinase activity
GUC46_RS04755	COG3437	response regulator, receiver
GUC46_RS04755	COG3850	Histidine kinase
GUC46_RS04755	COG4999	Histidine kinase
GUC46_RS04765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GUC46_RS04770	COG3956	TIGRFAM MazG family protein
GUC46_RS04800	COG1737	Transcriptional regulator
GUC46_RS04805	COG2190	(PTS) system
GUC46_RS04805	COG1263	PTS System
GUC46_RS04805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS04810	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GUC46_RS04815	COG0602	queuosine metabolic process
GUC46_RS04820	COG0720	synthase
GUC46_RS04840	COG2234	aminopeptidase activity
GUC46_RS04895	COG1388	LysM domain
GUC46_RS04895	COG4942	peptidase
GUC46_RS04910	COG0163	prenyltransferase activity
GUC46_RS04915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GUC46_RS04950	COG2200	EAL domain
GUC46_RS04955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GUC46_RS04960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GUC46_RS04965	COG1121	(ABC) transporter
GUC46_RS04985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GUC46_RS04990	COG1737	Transcriptional regulator
GUC46_RS04995	COG3069	C4-dicarboxylate transmembrane transporter activity
GUC46_RS05015	COG0309	Hydrogenase expression formation protein (HypE)
GUC46_RS05020	COG0409	Hydrogenase expression formation protein
GUC46_RS05025	COG0298	carbon dioxide binding
GUC46_RS05030	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GUC46_RS05035	COG0375	protein maturation
GUC46_RS05045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUC46_RS05050	COG0651	ATP synthesis coupled electron transport
GUC46_RS05055	COG0650	Formate hydrogenlyase subunit 4
GUC46_RS05060	COG3261	NADH dehydrogenase
GUC46_RS05060	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GUC46_RS05065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUC46_RS05070	COG3260	NADH ubiquinone oxidoreductase 20
GUC46_RS05080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GUC46_RS05090	COG2723	6-phospho-beta-galactosidase activity
GUC46_RS05095	COG1263	PTS System
GUC46_RS05095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS05100	COG1609	Transcriptional regulator
GUC46_RS05105	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUC46_RS05110	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GUC46_RS05130	COG0517	IMP dehydrogenase activity
GUC46_RS05130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GUC46_RS05135	COG1349	DNA-binding transcription factor activity
GUC46_RS05140	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS05155	COG3732	PTS system glucitol sorbitol-specific
GUC46_RS05160	COG3730	PTS system glucitol sorbitol-specific
GUC46_RS05165	COG2951	lytic endotransglycosylase activity
GUC46_RS05170	COG1546	Belongs to the CinA family
GUC46_RS05220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GUC46_RS05225	COG1238	metal cluster binding
GUC46_RS05245	COG2814	Major facilitator Superfamily
GUC46_RS05250	COG1566	PFAM secretion protein HlyD family protein
GUC46_RS05255	COG1846	Transcriptional regulator
GUC46_RS05265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GUC46_RS05270	COG2814	Major facilitator Superfamily
GUC46_RS05280	COG4176	ABC-type proline glycine betaine transport system permease component
GUC46_RS05310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GUC46_RS05330	COG2916	Histone family protein nucleoid-structuring protein H-NS
GUC46_RS05340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GUC46_RS05345	COG0640	Transcriptional regulator
GUC46_RS05350	COG0401	homolog of Blt101
GUC46_RS05355	COG1652	LysM domain
GUC46_RS05360	COG1802	Transcriptional regulator
GUC46_RS05365	COG1113	amino acid transport
GUC46_RS05370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GUC46_RS05375	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS05380	COG0579	oxidoreductase
GUC46_RS05410	COG2199	diguanylate cyclase activity
GUC46_RS05435	COG0642	Histidine kinase
GUC46_RS05445	COG3188	usher protein
GUC46_RS05450	COG3121	Chaperone
GUC46_RS05495	COG0438	transferase activity, transferring glycosyl groups
GUC46_RS05500	COG0297	glycogen (starch) synthase activity
GUC46_RS05500	COG0438	transferase activity, transferring glycosyl groups
GUC46_RS05540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GUC46_RS05545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GUC46_RS05550	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GUC46_RS05555	COG2271	Major facilitator Superfamily
GUC46_RS05560	COG2197	response regulator
GUC46_RS05565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUC46_RS05565	COG2198	Histidine kinase
GUC46_RS05565	COG2205	protein histidine kinase activity
GUC46_RS05565	COG0784	Response regulator, receiver
GUC46_RS05585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUC46_RS05590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS05595	COG3065	identical protein binding
GUC46_RS05610	COG3962	Belongs to the TPP enzyme family
GUC46_RS05615	COG0673	inositol 2-dehydrogenase activity
GUC46_RS05620	COG1879	ABC-type sugar transport system periplasmic component
GUC46_RS05630	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS05640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS05650	COG3718	enzyme involved in inositol metabolism
GUC46_RS05665	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
GUC46_RS05680	COG0582	viral genome integration into host DNA
GUC46_RS05690	COG4974	Belongs to the 'phage' integrase family
GUC46_RS05730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GUC46_RS05760	COG4695	Portal protein
GUC46_RS05865	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GUC46_RS05915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS05940	COG2867	negative regulation of translational initiation
GUC46_RS05955	COG0497	DNA recombination
GUC46_RS05970	COG4536	flavin adenine dinucleotide binding
GUC46_RS05975	COG4137	Cytochrome C assembly protein
GUC46_RS05980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GUC46_RS06005	COG2885	chlorophyll binding
GUC46_RS06010	COG2199	diguanylate cyclase activity
GUC46_RS06025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GUC46_RS06030	COG0287	Prephenate dehydrogenase
GUC46_RS06030	COG1605	Chorismate mutase
GUC46_RS06035	COG0077	Prephenate dehydratase
GUC46_RS06035	COG1605	Chorismate mutase
GUC46_RS06045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GUC46_RS06050	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GUC46_RS06055	COG0564	pseudouridine synthase activity
GUC46_RS06065	COG0542	response to heat
GUC46_RS06090	COG0477	Major facilitator Superfamily
GUC46_RS06095	COG5544	Lipoprotein
GUC46_RS06100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GUC46_RS06115	COG3118	belongs to the thioredoxin family
GUC46_RS06120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GUC46_RS06145	COG0513	Belongs to the DEAD box helicase family
GUC46_RS06155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GUC46_RS06165	COG1595	DNA-templated transcription, initiation
GUC46_RS06170	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GUC46_RS06175	COG3026	antisigma factor binding
GUC46_RS06180	COG3086	response to oxidative stress
GUC46_RS06190	COG0681	Belongs to the peptidase S26 family
GUC46_RS06210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GUC46_RS06220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUC46_RS06225	COG1737	Transcriptional regulator
GUC46_RS06230	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GUC46_RS06235	COG1263	PTS System
GUC46_RS06235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS06240	COG0560	Phosphoserine phosphatase
GUC46_RS06245	COG0590	tRNA wobble adenosine to inosine editing
GUC46_RS06260	COG2205	protein histidine kinase activity
GUC46_RS06265	COG3170	Tfp pilus assembly protein FimV
GUC46_RS06270	COG2204	response regulator
GUC46_RS06275	COG0347	Belongs to the P(II) protein family
GUC46_RS06280	COG1017	nitric oxide dioxygenase activity
GUC46_RS06280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GUC46_RS06310	COG4638	Rieske (2fe-2S)
GUC46_RS06315	COG0583	DNA-binding transcription factor activity
GUC46_RS06320	COG1940	carbohydrate kinase activity
GUC46_RS06325	COG0457	Tetratricopeptide repeat
GUC46_RS06330	COG2814	Major facilitator Superfamily
GUC46_RS06330	COG0477	Major facilitator Superfamily
GUC46_RS06340	COG2814	Major facilitator Superfamily
GUC46_RS06345	COG3711	transcriptional antiterminator
GUC46_RS06350	COG0517	IMP dehydrogenase activity
GUC46_RS06350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GUC46_RS06355	COG1069	ribulokinase activity
GUC46_RS06365	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS06370	COG1129	ABC transporter
GUC46_RS06380	COG3683	transport system, periplasmic component
GUC46_RS06385	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GUC46_RS06405	COG1104	cysteine desulfurase activity
GUC46_RS06410	COG0822	iron-sulfur transferase activity
GUC46_RS06430	COG0633	Ferredoxin
GUC46_RS06435	COG2975	iron-sulfur cluster assembly
GUC46_RS06450	COG2897	thiosulfate sulfurtransferase activity
GUC46_RS06455	COG2373	Large extracellular alpha-helical protein
GUC46_RS06460	COG4953	penicillin-binding protein 1C
GUC46_RS06475	COG1426	Protein conserved in bacteria
GUC46_RS06490	COG2976	Protein conserved in bacteria
GUC46_RS06505	COG3104	oligopeptide transport
GUC46_RS06515	COG1645	bacterial-type flagellum-dependent swarming motility
GUC46_RS06535	COG1570	exodeoxyribonuclease VII activity
GUC46_RS06540	COG0517	IMP dehydrogenase activity
GUC46_RS06540	COG0516	GMP reductase activity
GUC46_RS06550	COG0668	transmembrane transport
GUC46_RS06560	COG2200	EAL domain
GUC46_RS06565	COG0248	Ppx GppA phosphatase
GUC46_RS06575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GUC46_RS06585	COG2723	6-phospho-beta-galactosidase activity
GUC46_RS06595	COG2233	PERMEase
GUC46_RS06605	COG1393	Belongs to the ArsC family
GUC46_RS06610	COG4783	chaperone-mediated protein folding
GUC46_RS06615	COG0628	permease
GUC46_RS06620	COG3366	ferrous iron transmembrane transporter activity
GUC46_RS06625	COG0700	Nucleoside recognition
GUC46_RS06630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GUC46_RS06635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GUC46_RS06640	COG2716	regulation of RNA biosynthetic process
GUC46_RS06650	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GUC46_RS06660	COG2321	neutral zinc metallopeptidase
GUC46_RS06670	COG0400	carboxylic ester hydrolase activity
GUC46_RS06685	COG1393	Belongs to the ArsC family
GUC46_RS06695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUC46_RS06700	COG3850	Histidine kinase
GUC46_RS06705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUC46_RS06705	COG0493	'glutamate synthase
GUC46_RS06715	COG5342	invasion associated locus B
GUC46_RS06720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GUC46_RS06745	COG3501	Rhs element vgr protein
GUC46_RS06755	COG4917	ethanolamine utilization protein
GUC46_RS06760	COG4766	ethanolamine catabolic process
GUC46_RS06765	COG4812	Cobalamin adenosyltransferase
GUC46_RS06790	COG4820	ethanolamine utilization protein (EutJ)
GUC46_RS06820	COG4816	utilization protein
GUC46_RS06825	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GUC46_RS06830	COG2207	Transcriptional regulator
GUC46_RS06840	COG0860	N-Acetylmuramoyl-L-alanine amidase
GUC46_RS06860	COG2837	iron assimilation
GUC46_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS06875	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GUC46_RS06880	COG4208	sulfate ABC transporter
GUC46_RS06885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GUC46_RS06915	COG2190	(PTS) system
GUC46_RS06930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GUC46_RS06950	COG3530	Putative quorum-sensing-regulated virulence factor
GUC46_RS06955	COG0385	Bile acid
GUC46_RS06960	COG0583	DNA-binding transcription factor activity
GUC46_RS06970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GUC46_RS06975	COG2211	Major facilitator Superfamily
GUC46_RS06980	COG0583	DNA-binding transcription factor activity
GUC46_RS07015	COG3415	Transposase
GUC46_RS07020	COG3415	Transposase
GUC46_RS07035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GUC46_RS07050	COG0667	Aldo Keto reductase
GUC46_RS07055	COG3961	Belongs to the TPP enzyme family
GUC46_RS07070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS07075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS07080	COG0006	proline dipeptidase activity
GUC46_RS07085	COG1363	Peptidase, m42
GUC46_RS07090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GUC46_RS07090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS07090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS07105	COG2207	Transcriptional regulator
GUC46_RS07110	COG3279	Response regulator of the LytR AlgR family
GUC46_RS07115	COG3275	phosphorelay sensor kinase activity
GUC46_RS07120	COG0436	Aminotransferase
GUC46_RS07135	COG1560	Kdo2-lipid A biosynthetic process
GUC46_RS07150	COG1840	ABC-type Fe3 transport system, periplasmic component
GUC46_RS07165	COG3122	Protein conserved in bacteria
GUC46_RS07170	COG4977	sequence-specific DNA binding
GUC46_RS07170	COG1917	Cupin 2, conserved barrel domain protein
GUC46_RS07175	COG2197	response regulator
GUC46_RS07180	COG1285	pathogenesis
GUC46_RS07185	COG4413	Urea transporter
GUC46_RS07190	COG0829	nickel cation binding
GUC46_RS07195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GUC46_RS07210	COG0804	urea catabolic process
GUC46_RS07225	COG0004	ammonium transporteR
GUC46_RS07240	COG3247	response to pH
GUC46_RS07245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUC46_RS07250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS07255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GUC46_RS07260	COG2771	luxR family
GUC46_RS07265	COG3065	identical protein binding
GUC46_RS07275	COG0840	transmembrane signaling receptor activity
GUC46_RS07290	COG2161	toxin-antitoxin pair type II binding
GUC46_RS07325	COG2116	formate transmembrane transporter activity
GUC46_RS07335	COG2067	long-chain fatty acid transport protein
GUC46_RS07340	COG3691	Protein conserved in bacteria
GUC46_RS07355	COG2062	phosphohistidine phosphatase, SixA
GUC46_RS07365	COG2890	protein-(glutamine-N5) methyltransferase activity
GUC46_RS07380	COG0730	response to heat
GUC46_RS07385	COG3101	peptidyl-lysine hydroxylation
GUC46_RS07400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GUC46_RS07420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GUC46_RS07430	COG0586	Pfam SNARE associated Golgi protein
GUC46_RS07440	COG0285	dihydrofolate synthase activity
GUC46_RS07445	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GUC46_RS07450	COG1286	toxin biosynthetic process
GUC46_RS07455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GUC46_RS07460	COG0163	prenyltransferase activity
GUC46_RS07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUC46_RS07475	COG4215	(ABC) transporter
GUC46_RS07480	COG4160	amino acid transport
GUC46_RS07485	COG4598	ABC transporter
GUC46_RS07490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GUC46_RS07495	COG1090	epimerase
GUC46_RS07500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GUC46_RS07505	COG0625	glutathione transferase activity
GUC46_RS07510	COG0625	glutathione transferase activity
GUC46_RS07515	COG0622	Phosphoesterase
GUC46_RS07520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GUC46_RS07530	COG1288	antiporter activity
GUC46_RS07540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GUC46_RS07555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GUC46_RS07560	COG0471	metal ion transport
GUC46_RS07560	COG0490	domain, Protein
GUC46_RS07570	COG0436	Aminotransferase
GUC46_RS07575	COG0583	DNA-binding transcription factor activity
GUC46_RS07595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GUC46_RS07605	COG1034	ATP synthesis coupled electron transport
GUC46_RS07620	COG0839	Belongs to the complex I subunit 6 family
GUC46_RS07630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GUC46_RS07635	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUC46_RS07645	COG0784	Response regulator, receiver
GUC46_RS07645	COG0835	chemotaxis
GUC46_RS07655	COG2153	protein acetylation
GUC46_RS07660	COG4575	ribosome binding
GUC46_RS07665	COG1169	isochorismate synthase
GUC46_RS07735	COG0494	nUDIX hydrolase
GUC46_RS07750	COG5464	transposase or invertase
GUC46_RS07755	COG0247	lactate metabolic process
GUC46_RS07765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GUC46_RS07770	COG2271	Major facilitator Superfamily
GUC46_RS07775	COG0584	glycerophosphoryl diester phosphodiesterase
GUC46_RS07780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GUC46_RS07805	COG2205	protein histidine kinase activity
GUC46_RS07805	COG0784	Response regulator, receiver
GUC46_RS07815	COG2198	Histidine kinase
GUC46_RS07815	COG0642	Histidine kinase
GUC46_RS07820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GUC46_RS07825	COG1477	protein flavinylation
GUC46_RS07830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GUC46_RS07830	COG2169	Transcriptional regulator
GUC46_RS07835	COG3145	DNA-N1-methyladenine dioxygenase activity
GUC46_RS07840	COG4615	Cyclic peptide transporter
GUC46_RS07845	COG2239	Acts as a magnesium transporter
GUC46_RS07850	COG0659	secondary active sulfate transmembrane transporter activity
GUC46_RS07865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUC46_RS07865	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GUC46_RS07870	COG3062	negative regulation of establishment of protein localization
GUC46_RS07880	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS07885	COG0348	domain, Protein
GUC46_RS07890	COG3043	anaerobic respiration
GUC46_RS07895	COG3005	denitrification pathway
GUC46_RS07910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GUC46_RS07915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GUC46_RS07925	COG1138	Cytochrome C-type biogenesis protein
GUC46_RS07930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GUC46_RS07935	COG4235	cytochrome complex assembly
GUC46_RS07935	COG3088	subunit of a heme lyase
GUC46_RS07940	COG2197	response regulator
GUC46_RS07970	COG1061	Type III restriction enzyme res subunit
GUC46_RS07975	COG1187	pseudouridine synthase activity
GUC46_RS07980	COG2814	Major facilitator Superfamily
GUC46_RS07990	COG4172	Belongs to the ABC transporter superfamily
GUC46_RS07995	COG4239	(ABC) transporter, permease
GUC46_RS08000	COG4174	ABC transporter (Permease)
GUC46_RS08005	COG4166	transmembrane transport
GUC46_RS08010	COG2200	EAL domain
GUC46_RS08015	COG0791	NLP P60 protein
GUC46_RS08020	COG0671	phosphoesterase, PA-phosphatase related
GUC46_RS08025	COG0523	cobalamin synthesis protein
GUC46_RS08030	COG0246	Mannitol dehydrogenase
GUC46_RS08035	COG1312	Catalyzes the dehydration of D-mannonate
GUC46_RS08040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GUC46_RS08045	COG3005	denitrification pathway
GUC46_RS08055	COG3381	protein complex oligomerization
GUC46_RS08095	COG1230	cation diffusion facilitator family transporter
GUC46_RS08130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GUC46_RS08150	COG1105	Belongs to the carbohydrate kinase PfkB family
GUC46_RS08155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS08155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS08155	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GUC46_RS08160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GUC46_RS08170	COG0583	DNA-binding transcription factor activity
GUC46_RS08175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS08180	COG2313	pseudouridylate synthase activity
GUC46_RS08185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GUC46_RS08190	COG1522	sequence-specific DNA binding
GUC46_RS08190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS08200	COG2855	membrane
GUC46_RS08205	COG0583	DNA-binding transcription factor activity
GUC46_RS08210	COG0833	amino acid
GUC46_RS08215	COG4771	TonB-dependent receptor
GUC46_RS08220	COG2271	Major facilitator Superfamily
GUC46_RS08225	COG0560	Phosphoserine phosphatase
GUC46_RS08230	COG1760	l-serine dehydratase
GUC46_RS08250	COG2311	Membrane
GUC46_RS08265	COG1129	ABC transporter
GUC46_RS08280	COG0493	'glutamate synthase
GUC46_RS08290	COG2949	membrane
GUC46_RS08300	COG1346	cytolysis
GUC46_RS08315	COG2271	Major facilitator Superfamily
GUC46_RS08330	COG0625	glutathione transferase activity
GUC46_RS08335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUC46_RS08340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GUC46_RS08355	COG0586	Pfam SNARE associated Golgi protein
GUC46_RS08365	COG1686	Belongs to the peptidase S11 family
GUC46_RS08370	COG0277	FAD linked oxidase domain protein
GUC46_RS08375	COG1472	Belongs to the glycosyl hydrolase 3 family
GUC46_RS08380	COG1732	Glycine betaine
GUC46_RS08385	COG1174	glycine betaine transport
GUC46_RS08390	COG1125	glycine betaine transport
GUC46_RS08395	COG1174	glycine betaine transport
GUC46_RS08405	COG0789	Transcriptional regulator
GUC46_RS08410	COG3275	phosphorelay sensor kinase activity
GUC46_RS08420	COG4807	Protein conserved in bacteria
GUC46_RS08425	COG4808	Protein conserved in bacteria
GUC46_RS08435	COG0489	protein tyrosine kinase activity
GUC46_RS08450	COG3121	Chaperone
GUC46_RS08455	COG3188	usher protein
GUC46_RS08465	COG5455	response to cobalt ion
GUC46_RS08475	COG0351	phosphomethylpyrimidine kinase
GUC46_RS08480	COG2188	Transcriptional regulator
GUC46_RS08485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS08490	COG1397	ADP-ribosylglycohydrolase
GUC46_RS08495	COG2211	Major facilitator Superfamily
GUC46_RS08505	COG1830	Aldolase
GUC46_RS08515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUC46_RS08520	COG4160	amino acid transport
GUC46_RS08525	COG4215	(ABC) transporter
GUC46_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUC46_RS08535	COG1126	abc transporter atp-binding protein
GUC46_RS08550	COG3023	N-Acetylmuramoyl-L-alanine amidase
GUC46_RS08555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUC46_RS08560	COG0702	epimerase
GUC46_RS08565	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GUC46_RS08570	COG0028	Belongs to the TPP enzyme family
GUC46_RS08580	COG4529	Protein conserved in bacteria
GUC46_RS08585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GUC46_RS08595	COG2431	L-lysine efflux transmembrane transporter activity
GUC46_RS08600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GUC46_RS08605	COG3593	DNA synthesis involved in DNA repair
GUC46_RS08610	COG2990	Protein conserved in bacteria
GUC46_RS08615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS08625	COG1278	Cold shock
GUC46_RS08635	COG0542	response to heat
GUC46_RS08645	COG3422	double-strand break repair
GUC46_RS08650	COG0745	RESPONSE REGULATOR receiver
GUC46_RS08655	COG2205	protein histidine kinase activity
GUC46_RS08685	COG0443	Heat shock 70 kDa protein
GUC46_RS08690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GUC46_RS08695	COG5001	Diguanylate cyclase
GUC46_RS08695	COG5002	protein histidine kinase activity
GUC46_RS08695	COG3447	MASE1 domain protein
GUC46_RS08710	COG2982	Protein involved in outer membrane biogenesis
GUC46_RS08715	COG1253	flavin adenine dinucleotide binding
GUC46_RS08730	COG3206	protein involved in exopolysaccharide biosynthesis
GUC46_RS08730	COG0489	protein tyrosine kinase activity
GUC46_RS08735	COG0463	Glycosyl transferase, family 2
GUC46_RS08740	COG1045	serine acetyltransferase
GUC46_RS08745	COG0438	transferase activity, transferring glycosyl groups
GUC46_RS08755	COG1216	Glycosyl transferase, family 2
GUC46_RS08760	COG0110	maltose O-acetyltransferase activity
GUC46_RS08765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GUC46_RS08770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUC46_RS08775	COG1051	belongs to the nudix hydrolase family
GUC46_RS08780	COG0297	glycogen (starch) synthase activity
GUC46_RS08790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GUC46_RS08795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GUC46_RS08800	COG2244	polysaccharide biosynthetic process
GUC46_RS08805	COG2327	Polysaccharide pyruvyl transferase
GUC46_RS08820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUC46_RS08825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GUC46_RS08850	COG0438	transferase activity, transferring glycosyl groups
GUC46_RS08865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GUC46_RS08880	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GUC46_RS08900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GUC46_RS08930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GUC46_RS08935	COG0583	DNA-binding transcription factor activity
GUC46_RS08945	COG0531	amino acid
GUC46_RS08950	COG2925	Exonuclease
GUC46_RS08960	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS08980	COG1289	transmembrane transporter activity
GUC46_RS09005	COG4810	utilization protein
GUC46_RS09015	COG4656	Part of a membrane complex involved in electron transport
GUC46_RS09025	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS09055	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GUC46_RS09090	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GUC46_RS09125	COG2241	protein methyltransferase activity
GUC46_RS09135	COG2875	Belongs to the precorrin methyltransferase family
GUC46_RS09205	COG1376	ErfK ybiS ycfS ynhG family protein
GUC46_RS09210	COG3842	ATPase activity
GUC46_RS09215	COG1178	ABC-type Fe3 transport system permease component
GUC46_RS09220	COG1840	ABC-type Fe3 transport system, periplasmic component
GUC46_RS09240	COG2076	Multidrug Resistance protein
GUC46_RS09245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GUC46_RS09250	COG1418	mRNA catabolic process
GUC46_RS09255	COG0270	DNA (cytosine-5-)-methyltransferase activity
GUC46_RS09260	COG3727	T/G mismatch-specific endonuclease activity
GUC46_RS09265	COG0697	spore germination
GUC46_RS09270	COG2354	Protein conserved in bacteria
GUC46_RS09275	COG5475	Uncharacterized small protein (DUF2158)
GUC46_RS09300	COG1987	bacterial-type flagellum assembly
GUC46_RS09310	COG3190	flagellar
GUC46_RS09335	COG2882	bacterial-type flagellum organization
GUC46_RS09340	COG1157	protein secretion by the type III secretion system
GUC46_RS09350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GUC46_RS09375	COG2246	polysaccharide biosynthetic process
GUC46_RS09380	COG0425	Belongs to the sulfur carrier protein TusA family
GUC46_RS09395	COG0366	Alpha amylase catalytic
GUC46_RS09420	COG1191	sigma factor activity
GUC46_RS09450	COG2197	response regulator
GUC46_RS09460	COG2197	response regulator
GUC46_RS09595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GUC46_RS09610	COG1403	HNH endonuclease
GUC46_RS09630	COG3772	lysozyme
GUC46_RS09655	COG1802	Transcriptional regulator
GUC46_RS09655	COG4626	Terminase
GUC46_RS09665	COG4695	Portal protein
GUC46_RS09810	COG1305	Transglutaminase-like
GUC46_RS09820	COG2608	mercury ion transmembrane transporter activity
GUC46_RS09825	COG3012	SEC-C Motif Domain Protein
GUC46_RS09825	COG3318	Belongs to the UPF0149 family
GUC46_RS09830	COG0814	amino acid
GUC46_RS09840	COG1528	Iron-storage protein
GUC46_RS09855	COG0477	Major facilitator Superfamily
GUC46_RS09865	COG1528	Iron-storage protein
GUC46_RS09875	COG1879	ABC-type sugar transport system periplasmic component
GUC46_RS09880	COG1129	ABC transporter
GUC46_RS09885	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS09900	COG0589	response to stress
GUC46_RS09930	COG0835	chemotaxis
GUC46_RS09935	COG1301	dicarboxylic acid transport
GUC46_RS09945	COG0840	transmembrane signaling receptor activity
GUC46_RS09960	COG0745	RESPONSE REGULATOR receiver
GUC46_RS09985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GUC46_RS10000	COG3102	Protein conserved in bacteria
GUC46_RS10020	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GUC46_RS10025	COG1801	Protein of unknown function DUF72
GUC46_RS10030	COG1335	isochorismatase
GUC46_RS10040	COG0494	nUDIX hydrolase
GUC46_RS10065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GUC46_RS10075	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GUC46_RS10080	COG0739	heme binding
GUC46_RS10085	COG1560	Kdo2-lipid A biosynthetic process
GUC46_RS10095	COG1737	Transcriptional regulator
GUC46_RS10100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GUC46_RS10105	COG0129	dihydroxy-acid dehydratase activity
GUC46_RS10110	COG0800	Aldolase
GUC46_RS10120	COG3141	response to X-ray
GUC46_RS10130	COG2979	Protein of unknown function (DUF533)
GUC46_RS10135	COG1770	oligopeptidase
GUC46_RS10140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GUC46_RS10145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GUC46_RS10155	COG2372	response to copper ion
GUC46_RS10160	COG1276	copper resistance
GUC46_RS10170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GUC46_RS10190	COG3008	intermembrane lipid transfer
GUC46_RS10195	COG2995	paraquat-inducible protein a
GUC46_RS10200	COG1956	GAF domain-containing protein
GUC46_RS10220	COG2814	Major facilitator Superfamily
GUC46_RS10225	COG1414	Transcriptional regulator
GUC46_RS10250	COG1278	Cold shock
GUC46_RS10255	COG0768	penicillin binding
GUC46_RS10260	COG2226	methyltransferase
GUC46_RS10275	COG3716	PTS system mannose fructose sorbose family IID component
GUC46_RS10280	COG3715	PTS system
GUC46_RS10285	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS10285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS10290	COG1253	flavin adenine dinucleotide binding
GUC46_RS10295	COG2200	EAL domain
GUC46_RS10300	COG1760	l-serine dehydratase
GUC46_RS10320	COG0251	oxidation-reduction process
GUC46_RS10325	COG1199	ATP-dependent helicase activity
GUC46_RS10330	COG1214	PFAM Peptidase M22, glycoprotease
GUC46_RS10335	COG3065	identical protein binding
GUC46_RS10340	COG0318	PFAM AMP-dependent synthetase and ligase
GUC46_RS10345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GUC46_RS10350	COG0473	3-isopropylmalate dehydrogenase activity
GUC46_RS10355	COG0583	DNA-binding transcription factor activity
GUC46_RS10365	COG2894	cell division
GUC46_RS10380	COG0179	Fumarylacetoacetate (FAA) hydrolase
GUC46_RS10410	COG2719	SpoVR family
GUC46_RS10420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GUC46_RS10430	COG1619	proteins homologs of microcin C7 resistance protein MccF
GUC46_RS10455	COG0157	Belongs to the NadC ModD family
GUC46_RS10460	COG0500	methyltransferase
GUC46_RS10465	COG1120	ATPase activity
GUC46_RS10490	COG1461	Dihydroxyacetone kinase
GUC46_RS10495	COG2376	Dihydroxyacetone kinase
GUC46_RS10500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GUC46_RS10525	COG0789	Transcriptional regulator
GUC46_RS10530	COG2200	EAL domain
GUC46_RS10555	COG2826	transposase and inactivated derivatives, IS30 family
GUC46_RS10585	COG0012	GTP binding
GUC46_RS10600	COG0527	aspartate kinase activity
GUC46_RS10605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GUC46_RS10610	COG0076	glutamate decarboxylase activity
GUC46_RS10615	COG0659	secondary active sulfate transmembrane transporter activity
GUC46_RS10620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GUC46_RS10645	COG2890	protein-(glutamine-N5) methyltransferase activity
GUC46_RS10650	COG3094	Invasion gene expression up-regulator, SirB
GUC46_RS10655	COG2912	Transglutaminase-like superfamily
GUC46_RS10665	COG0387	Pfam Sodium calcium exchanger
GUC46_RS10670	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GUC46_RS10680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GUC46_RS10685	COG4932	domain protein
GUC46_RS10690	COG2197	response regulator
GUC46_RS10695	COG3850	Histidine kinase
GUC46_RS10700	COG2223	nitrite transmembrane transporter activity
GUC46_RS10705	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GUC46_RS10710	COG1140	nitrate reductase beta subunit
GUC46_RS10715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GUC46_RS10720	COG2181	nitrate reductase activity
GUC46_RS10740	COG0788	formyltetrahydrofolate deformylase activity
GUC46_RS10750	COG1752	Esterase of the alpha-beta hydrolase superfamily
GUC46_RS10755	COG0745	RESPONSE REGULATOR receiver
GUC46_RS10760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GUC46_RS10770	COG1435	thymidine kinase activity
GUC46_RS10775	COG1454	alcohol dehydrogenase
GUC46_RS10775	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS10780	COG2095	MarC family integral membrane protein
GUC46_RS10800	COG0444	Belongs to the ABC transporter superfamily
GUC46_RS10810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GUC46_RS10830	COG2350	Protein conserved in bacteria
GUC46_RS10840	COG1607	acyl-coa hydrolase
GUC46_RS10855	COG3047	cAMP biosynthetic process
GUC46_RS10875	COG3706	GGDEF domain
GUC46_RS10915	COG0009	L-threonylcarbamoyladenylate synthase
GUC46_RS10920	COG1187	pseudouridine synthase activity
GUC46_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS10935	COG0616	signal peptide processing
GUC46_RS10945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GUC46_RS10950	COG0583	DNA-binding transcription factor activity
GUC46_RS10960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GUC46_RS10970	COG0671	phosphoesterase, PA-phosphatase related
GUC46_RS10975	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GUC46_RS10980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GUC46_RS10990	COG0023	Translation Initiation Factor
GUC46_RS11000	COG1349	DNA-binding transcription factor activity
GUC46_RS11010	COG5001	Diguanylate cyclase
GUC46_RS11020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GUC46_RS11020	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GUC46_RS11025	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GUC46_RS11045	COG4171	peptide transport system, permease
GUC46_RS11050	COG4168	peptide transport system, permease
GUC46_RS11070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GUC46_RS11075	COG1842	Phage shock protein A
GUC46_RS11085	COG1983	PspC domain protein
GUC46_RS11095	COG0366	Alpha amylase catalytic
GUC46_RS11100	COG1653	transport
GUC46_RS11105	COG1175	transmembrane transport
GUC46_RS11110	COG0395	ABC-type sugar transport system, permease component
GUC46_RS11115	COG1063	alcohol dehydrogenase
GUC46_RS11120	COG1082	Xylose isomerase domain protein TIM barrel
GUC46_RS11125	COG0673	inositol 2-dehydrogenase activity
GUC46_RS11130	COG1554	hydrolase, family 65, central catalytic
GUC46_RS11135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GUC46_RS11150	COG1609	Transcriptional regulator
GUC46_RS11155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GUC46_RS11160	COG3106	COG3106 Predicted ATPase
GUC46_RS11175	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GUC46_RS11180	COG4948	Mandelate Racemase Muconate Lactonizing
GUC46_RS11185	COG2866	Carboxypeptidase
GUC46_RS11190	COG4166	transmembrane transport
GUC46_RS11210	COG1349	DNA-binding transcription factor activity
GUC46_RS11215	COG0346	lactoylglutathione lyase activity
GUC46_RS11225	COG1064	alcohol dehydrogenase
GUC46_RS11230	COG0668	transmembrane transport
GUC46_RS11235	COG3182	Iron-regulated membrane protein
GUC46_RS11250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GUC46_RS11255	COG2840	Smr protein MutS2
GUC46_RS11260	COG3706	GGDEF domain
GUC46_RS11270	COG0840	transmembrane signaling receptor activity
GUC46_RS11280	COG0513	Belongs to the DEAD box helicase family
GUC46_RS11290	COG0589	response to stress
GUC46_RS11300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GUC46_RS11305	COG0674	pyruvate-flavodoxin oxidoreductase activity
GUC46_RS11305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GUC46_RS11305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GUC46_RS11305	COG1013	pyruvate-flavodoxin oxidoreductase activity
GUC46_RS11310	COG3042	response to heat
GUC46_RS11315	COG3187	Heat shock protein
GUC46_RS11320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GUC46_RS11330	COG2911	Protein conserved in bacteria
GUC46_RS11340	COG3784	Protein of unknown function (DUF1318)
GUC46_RS11345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GUC46_RS11350	COG4589	Belongs to the CDS family
GUC46_RS11360	COG2267	carboxylic ester hydrolase activity
GUC46_RS11365	COG2453	phosphatase
GUC46_RS11365	COG0671	phosphoesterase, PA-phosphatase related
GUC46_RS11385	COG1643	Atp-dependent helicase
GUC46_RS11390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GUC46_RS11395	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS11400	COG2755	lipolytic protein G-D-S-L family
GUC46_RS11400	COG0657	acetylesterase activity
GUC46_RS11405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GUC46_RS11410	COG3038	cytochrome b561
GUC46_RS11420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GUC46_RS11425	COG2864	formate dehydrogenase
GUC46_RS11430	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS11435	COG0243	molybdopterin cofactor binding
GUC46_RS11435	COG3383	formate dehydrogenase (NAD+) activity
GUC46_RS11445	COG3059	membrane
GUC46_RS11465	COG0840	transmembrane signaling receptor activity
GUC46_RS11470	COG0583	DNA-binding transcription factor activity
GUC46_RS11475	COG1227	inorganic diphosphatase activity
GUC46_RS11480	COG5383	Protein conserved in bacteria
GUC46_RS11490	COG2841	Protein conserved in bacteria
GUC46_RS11500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GUC46_RS11505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GUC46_RS11510	COG1275	C4-dicarboxylate transporter malic acid transport protein
GUC46_RS11515	COG0500	methyltransferase
GUC46_RS11535	COG3135	benzoate transporter
GUC46_RS11540	COG1396	sequence-specific DNA binding
GUC46_RS11545	COG0826	peptidase U32
GUC46_RS11560	COG1294	oxidase, subunit
GUC46_RS11565	COG1271	oxidase subunit
GUC46_RS11570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GUC46_RS11575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GUC46_RS11580	COG3842	ATPase activity
GUC46_RS11585	COG1176	ABC-type spermidine putrescine transport system, permease component I
GUC46_RS11590	COG1177	transmembrane transport
GUC46_RS11600	COG2814	Major facilitator Superfamily
GUC46_RS11605	COG2207	Transcriptional regulator
GUC46_RS11635	COG0747	negative chemotaxis
GUC46_RS11645	COG3238	Protein conserved in bacteria
GUC46_RS11650	COG1247	-acetyltransferase
GUC46_RS11660	COG2130	NADP-dependent
GUC46_RS11680	COG0840	transmembrane signaling receptor activity
GUC46_RS11685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GUC46_RS11695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GUC46_RS11700	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GUC46_RS11715	COG1126	abc transporter atp-binding protein
GUC46_RS11725	COG0583	DNA-binding transcription factor activity
GUC46_RS11730	COG0625	glutathione transferase activity
GUC46_RS11750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GUC46_RS11755	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GUC46_RS11760	COG0384	phenazine biosynthesis protein PhzF
GUC46_RS11765	COG2181	nitrate reductase activity
GUC46_RS11770	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GUC46_RS11775	COG1140	nitrate reductase beta subunit
GUC46_RS11780	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GUC46_RS11785	COG2223	nitrite transmembrane transporter activity
GUC46_RS11810	COG0697	spore germination
GUC46_RS11820	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS11825	COG2864	formate dehydrogenase
GUC46_RS11830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GUC46_RS11850	COG1764	response to oxidative stress
GUC46_RS11855	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS11860	COG2610	gluconate transmembrane transporter activity
GUC46_RS11865	COG1250	3-hydroxyacyl-CoA dehydrogenase
GUC46_RS11875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GUC46_RS11880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GUC46_RS11890	COG4608	Belongs to the ABC transporter superfamily
GUC46_RS11895	COG0444	Belongs to the ABC transporter superfamily
GUC46_RS11900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GUC46_RS11905	COG0601	transmembrane transport
GUC46_RS11910	COG0747	negative chemotaxis
GUC46_RS11915	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GUC46_RS11930	COG0840	transmembrane signaling receptor activity
GUC46_RS11955	COG4628	conserved protein (DUF2132)
GUC46_RS11980	COG3121	Chaperone
GUC46_RS11995	COG3121	Chaperone
GUC46_RS12025	COG3781	membrane
GUC46_RS12065	COG0246	Mannitol dehydrogenase
GUC46_RS12090	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS12095	COG0583	DNA-binding transcription factor activity
GUC46_RS12110	COG1846	Transcriptional regulator
GUC46_RS12130	COG2814	Major facilitator Superfamily
GUC46_RS12140	COG1122	ATPase activity
GUC46_RS12150	COG0559	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS12165	COG3706	GGDEF domain
GUC46_RS12180	COG4221	oxidoreductase activity
GUC46_RS12185	COG1802	Transcriptional regulator
GUC46_RS12195	COG0246	Mannitol dehydrogenase
GUC46_RS12200	COG0477	Major facilitator Superfamily
GUC46_RS12205	COG1063	alcohol dehydrogenase
GUC46_RS12210	COG4948	Mandelate Racemase Muconate Lactonizing
GUC46_RS12225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GUC46_RS12240	COG0243	molybdopterin cofactor binding
GUC46_RS12245	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS12250	COG3302	dmso reductase anchor subunit
GUC46_RS12255	COG3381	protein complex oligomerization
GUC46_RS12265	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GUC46_RS12270	COG1940	carbohydrate kinase activity
GUC46_RS12275	COG0583	DNA-binding transcription factor activity
GUC46_RS12280	COG2814	Major facilitator Superfamily
GUC46_RS12290	COG5002	protein histidine kinase activity
GUC46_RS12295	COG0745	RESPONSE REGULATOR receiver
GUC46_RS12310	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GUC46_RS12320	COG3591	Belongs to the peptidase S1B family
GUC46_RS12340	COG0628	permease
GUC46_RS12345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GUC46_RS12350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GUC46_RS12360	COG0531	amino acid
GUC46_RS12370	COG3136	membrane protein required for alginate biosynthesis
GUC46_RS12375	COG0745	RESPONSE REGULATOR receiver
GUC46_RS12385	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GUC46_RS12395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUC46_RS12410	COG2205	protein histidine kinase activity
GUC46_RS12425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GUC46_RS12425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GUC46_RS12430	COG1482	cell wall glycoprotein biosynthetic process
GUC46_RS12435	COG5339	Protein conserved in bacteria
GUC46_RS12440	COG1609	Transcriptional regulator
GUC46_RS12445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS12445	COG1263	PTS System
GUC46_RS12450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GUC46_RS12460	COG0673	inositol 2-dehydrogenase activity
GUC46_RS12500	COG4659	FMN binding
GUC46_RS12510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GUC46_RS12520	COG0625	glutathione transferase activity
GUC46_RS12525	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GUC46_RS12540	COG3895	Periplasmic Protein
GUC46_RS12550	COG3133	Outer membrane lipoprotein
GUC46_RS12565	COG1566	PFAM secretion protein HlyD family protein
GUC46_RS12575	COG2032	superoxide dismutase activity
GUC46_RS12580	COG4989	oxidoreductase activity
GUC46_RS12585	COG3313	Fe-S protein
GUC46_RS12590	COG1309	transcriptional regulator
GUC46_RS12595	COG1902	pentaerythritol trinitrate reductase activity
GUC46_RS12600	COG0346	lactoylglutathione lyase activity
GUC46_RS12610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GUC46_RS12615	COG0791	NLP P60 protein
GUC46_RS12620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GUC46_RS12625	COG2814	Major facilitator Superfamily
GUC46_RS12640	COG0583	DNA-binding transcription factor activity
GUC46_RS12645	COG2814	Major facilitator Superfamily
GUC46_RS12650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GUC46_RS12655	COG0307	riboflavin synthase, alpha
GUC46_RS12680	COG0251	oxidation-reduction process
GUC46_RS12700	COG5001	Diguanylate cyclase
GUC46_RS12700	COG3300	MHYT domain
GUC46_RS12705	COG0386	Belongs to the glutathione peroxidase family
GUC46_RS12710	COG0628	permease
GUC46_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS12730	COG2378	regulation of single-species biofilm formation
GUC46_RS12745	COG3121	Chaperone
GUC46_RS12750	COG3188	usher protein
GUC46_RS12765	COG4977	sequence-specific DNA binding
GUC46_RS12810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GUC46_RS12825	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GUC46_RS12835	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS12850	COG1113	amino acid transport
GUC46_RS12855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GUC46_RS12860	COG0129	dihydroxy-acid dehydratase activity
GUC46_RS12865	COG2271	Major facilitator Superfamily
GUC46_RS12870	COG0800	Aldolase
GUC46_RS12875	COG3734	2-keto-3-deoxy-galactonokinase
GUC46_RS12895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUC46_RS12905	COG4160	amino acid transport
GUC46_RS12910	COG0765	amino acid transport
GUC46_RS12920	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GUC46_RS12925	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS12935	COG2414	aldehyde ferredoxin oxidoreductase
GUC46_RS12940	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS12990	COG1464	Belongs to the NlpA lipoprotein family
GUC46_RS12995	COG2011	ABC-type metal ion transport system permease component
GUC46_RS13005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS13020	COG0531	amino acid
GUC46_RS13035	COG1376	ErfK ybiS ycfS ynhG family protein
GUC46_RS13050	COG0719	Fe-S assembly protein
GUC46_RS13055	COG0396	ATPase activity
GUC46_RS13060	COG0719	Fe-S assembly protein
GUC46_RS13065	COG0316	Belongs to the HesB IscA family
GUC46_RS13070	COG0583	DNA-binding transcription factor activity
GUC46_RS13085	COG2050	protein possibly involved in aromatic compounds catabolism
GUC46_RS13090	COG0277	FAD linked oxidase domain protein
GUC46_RS13090	COG0247	lactate metabolic process
GUC46_RS13095	COG0628	permease
GUC46_RS13110	COG0738	Major facilitator superfamily
GUC46_RS13115	COG2271	Major facilitator Superfamily
GUC46_RS13130	COG4670	ketone body catabolic process
GUC46_RS13135	COG1960	acyl-CoA dehydrogenase activity
GUC46_RS13140	COG2207	Transcriptional regulator
GUC46_RS13140	COG1917	Cupin 2, conserved barrel domain protein
GUC46_RS13145	COG2086	electron transfer activity
GUC46_RS13150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GUC46_RS13155	COG0644	oxidoreductase
GUC46_RS13160	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GUC46_RS13165	COG0318	PFAM AMP-dependent synthetase and ligase
GUC46_RS13170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GUC46_RS13170	COG0574	Belongs to the PEP-utilizing enzyme family
GUC46_RS13180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GUC46_RS13185	COG4256	Hemin uptake protein
GUC46_RS13190	COG4771	TonB-dependent receptor
GUC46_RS13195	COG3720	iron ion transport
GUC46_RS13200	COG4558	Periplasmic binding protein
GUC46_RS13205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUC46_RS13225	COG0791	NLP P60 protein
GUC46_RS13235	COG0386	Belongs to the glutathione peroxidase family
GUC46_RS13270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GUC46_RS13290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GUC46_RS13425	COG5484	DNA packaging
GUC46_RS13425	COG3728	DNA packaging
GUC46_RS13445	COG3646	Phage regulatory protein
GUC46_RS13455	COG3772	lysozyme
GUC46_RS13480	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GUC46_RS13665	COG3137	Salt-induced outer membrane protein
GUC46_RS13670	COG1105	Belongs to the carbohydrate kinase PfkB family
GUC46_RS13685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GUC46_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS13695	COG1988	membrane-bound metal-dependent
GUC46_RS13710	COG0753	catalase activity
GUC46_RS13720	COG1486	melibiose metabolic process
GUC46_RS13725	COG2169	Transcriptional regulator
GUC46_RS13725	COG1917	Cupin 2, conserved barrel domain protein
GUC46_RS13730	COG1447	Phosphotransferase system cellobiose-specific component IIA
GUC46_RS13735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GUC46_RS13740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GUC46_RS13745	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GUC46_RS13755	COG0322	excinuclease ABC activity
GUC46_RS13765	COG3678	ATP-independent chaperone mediated protein folding
GUC46_RS13785	COG3138	arginine N-succinyltransferase
GUC46_RS13795	COG0708	Exodeoxyribonuclease III
GUC46_RS13800	COG0398	Pfam SNARE associated Golgi protein
GUC46_RS13805	COG0398	Pfam SNARE associated Golgi protein
GUC46_RS13810	COG4134	Bacterial extracellular solute-binding protein
GUC46_RS13815	COG4135	transport system, permease component
GUC46_RS13820	COG4136	ATPase activity
GUC46_RS13825	COG2897	thiosulfate sulfurtransferase activity
GUC46_RS13830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GUC46_RS13835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GUC46_RS13840	COG0494	nUDIX hydrolase
GUC46_RS13855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GUC46_RS13865	COG0778	Nitroreductase
GUC46_RS13870	COG0616	signal peptide processing
GUC46_RS13875	COG0252	asparaginase activity
GUC46_RS13880	COG1335	isochorismatase
GUC46_RS13885	COG2814	Major facilitator Superfamily
GUC46_RS13890	COG1349	DNA-binding transcription factor activity
GUC46_RS13895	COG0667	Aldo Keto reductase
GUC46_RS13900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS13905	COG0191	fructose-bisphosphate aldolase activity
GUC46_RS13910	COG1063	alcohol dehydrogenase
GUC46_RS13915	COG2271	Major facilitator Superfamily
GUC46_RS13920	COG1063	alcohol dehydrogenase
GUC46_RS13930	COG1403	HNH endonuclease
GUC46_RS13935	COG3139	Protein of unknown function (DUF1315)
GUC46_RS13945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GUC46_RS13955	COG0656	L-ascorbic acid biosynthetic process
GUC46_RS13960	COG3713	MltA-interacting MipA family protein
GUC46_RS13965	COG2766	serine protein kinase
GUC46_RS13975	COG2226	methyltransferase
GUC46_RS13980	COG2199	diguanylate cyclase activity
GUC46_RS13985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GUC46_RS13995	COG2207	Transcriptional regulator
GUC46_RS14000	COG2807	transmembrane transport
GUC46_RS14005	COG0504	CTP synthase activity
GUC46_RS14010	COG3189	MarR family transcriptional regulator
GUC46_RS14015	COG3042	response to heat
GUC46_RS14020	COG2199	diguanylate cyclase activity
GUC46_RS14020	COG2203	Gaf domain
GUC46_RS14035	COG2261	transglycosylase associated protein
GUC46_RS14040	COG3383	formate dehydrogenase (NAD+) activity
GUC46_RS14055	COG3615	Tellurite resistance protein tehB
GUC46_RS14065	COG3443	Belongs to the bacterial solute-binding protein 9 family
GUC46_RS14070	COG1124	(ABC) transporter
GUC46_RS14080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GUC46_RS14085	COG0601	transmembrane transport
GUC46_RS14090	COG0747	negative chemotaxis
GUC46_RS14095	COG4771	TonB-dependent receptor
GUC46_RS14110	COG2200	EAL domain
GUC46_RS14135	COG2826	transposase and inactivated derivatives, IS30 family
GUC46_RS14155	COG0431	NADPH-dependent FMN reductase
GUC46_RS14160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GUC46_RS14175	COG0538	isocitrate dehydrogenase activity
GUC46_RS14205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GUC46_RS14215	COG3038	cytochrome b561
GUC46_RS14235	COG4221	oxidoreductase activity
GUC46_RS14250	COG0745	RESPONSE REGULATOR receiver
GUC46_RS14260	COG2850	peptidyl-arginine hydroxylation
GUC46_RS14275	COG1176	ABC-type spermidine putrescine transport system, permease component I
GUC46_RS14280	COG1177	transmembrane transport
GUC46_RS14285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GUC46_RS14290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GUC46_RS14300	COG4591	ABC-type transport system involved in lipoprotein release permease component
GUC46_RS14310	COG4591	ABC-type transport system involved in lipoprotein release permease component
GUC46_RS14315	COG4763	Acyl-transferase
GUC46_RS14320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GUC46_RS14325	COG1376	ErfK ybiS ycfS ynhG family protein
GUC46_RS14325	COG1388	LysM domain
GUC46_RS14335	COG1309	transcriptional regulator
GUC46_RS14345	COG3134	Outer membrane lipoprotein
GUC46_RS14350	COG1252	NADH dehydrogenase
GUC46_RS14375	COG5633	Lipoprotein
GUC46_RS14380	COG0537	adenosine 5'-monophosphoramidase activity
GUC46_RS14385	COG4773	Receptor
GUC46_RS14390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GUC46_RS14395	COG3327	negative regulation of DNA-templated transcription, initiation
GUC46_RS14400	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GUC46_RS14405	COG0183	Belongs to the thiolase family
GUC46_RS14410	COG2050	protein possibly involved in aromatic compounds catabolism
GUC46_RS14415	COG1250	3-hydroxyacyl-CoA dehydrogenase
GUC46_RS14420	COG1024	Enoyl-CoA hydratase
GUC46_RS14425	COG1024	Enoyl-CoA hydratase
GUC46_RS14430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GUC46_RS14435	COG2151	metal-sulfur cluster biosynthetic enzyme
GUC46_RS14440	COG3396	Phenylacetate-CoA oxygenase
GUC46_RS14445	COG3460	Phenylacetate-CoA oxygenase
GUC46_RS14450	COG3396	Phenylacetate-CoA oxygenase
GUC46_RS14455	COG2030	dehydratase
GUC46_RS14455	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS14465	COG0534	Mate efflux family protein
GUC46_RS14475	COG0583	DNA-binding transcription factor activity
GUC46_RS14495	COG1595	DNA-templated transcription, initiation
GUC46_RS14500	COG3712	iron ion homeostasis
GUC46_RS14505	COG4772	TonB-dependent receptor
GUC46_RS14510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GUC46_RS14515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUC46_RS14520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUC46_RS14525	COG1120	ATPase activity
GUC46_RS14555	COG0477	Major facilitator Superfamily
GUC46_RS14560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GUC46_RS14570	COG1263	PTS System
GUC46_RS14570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS14575	COG0084	hydrolase, TatD family'
GUC46_RS14580	COG0470	DNA polymerase III
GUC46_RS14590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GUC46_RS14595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GUC46_RS14600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GUC46_RS14610	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS14615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GUC46_RS14635	COG1399	metal-binding, possibly nucleic acid-binding protein
GUC46_RS14645	COG0564	pseudouridine synthase activity
GUC46_RS14650	COG1530	ribonuclease E activity
GUC46_RS14655	COG0583	DNA-binding transcription factor activity
GUC46_RS14660	COG2814	Major facilitator Superfamily
GUC46_RS14670	COG1256	bacterial-type flagellum assembly
GUC46_RS14690	COG4786	Flagellar basal body rod
GUC46_RS14695	COG4787	bacterial-type flagellum-dependent cell motility
GUC46_RS14700	COG1749	Flagellar hook protein flgE
GUC46_RS14705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GUC46_RS14710	COG1558	bacterial-type flagellum-dependent cell motility
GUC46_RS14730	COG3418	PFAM FlgN family protein
GUC46_RS14750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GUC46_RS14790	COG3038	cytochrome b561
GUC46_RS14805	COG1560	Kdo2-lipid A biosynthetic process
GUC46_RS14815	COG2199	diguanylate cyclase activity
GUC46_RS14825	COG5645	(Lipo)protein
GUC46_RS14845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GUC46_RS14900	COG3381	protein complex oligomerization
GUC46_RS14930	COG2962	Rard protein
GUC46_RS14935	COG2990	Protein conserved in bacteria
GUC46_RS14940	COG1702	phosphate starvation-inducible protein PhoH
GUC46_RS14950	COG2822	iron ion transport
GUC46_RS14955	COG0672	)-iron permease
GUC46_RS14960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GUC46_RS14965	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GUC46_RS14965	COG0506	proline dehydrogenase activity
GUC46_RS14965	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GUC46_RS14970	COG3755	Protein conserved in bacteria
GUC46_RS14975	COG1309	transcriptional regulator
GUC46_RS14985	COG3729	General stress protein
GUC46_RS15005	COG0640	Transcriptional regulator
GUC46_RS15015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GUC46_RS15020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GUC46_RS15020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GUC46_RS15070	COG0813	purine-nucleoside phosphorylase activity
GUC46_RS15085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUC46_RS15090	COG1120	ATPase activity
GUC46_RS15100	COG0723	plastoquinol--plastocyanin reductase activity
GUC46_RS15105	COG2857	Cytochrome c1
GUC46_RS15105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GUC46_RS15125	COG0670	Belongs to the BI1 family
GUC46_RS15150	COG1832	CoA-binding protein
GUC46_RS15165	COG0210	DNA helicase
GUC46_RS15170	COG3304	Inner membrane component domain
GUC46_RS15175	COG1289	transmembrane transporter activity
GUC46_RS15180	COG3070	regulator of competence-specific genes
GUC46_RS15200	COG1067	ATP-dependent peptidase activity
GUC46_RS15210	COG3130	regulation of translation
GUC46_RS15215	COG3009	Protein conserved in bacteria
GUC46_RS15220	COG3008	intermembrane lipid transfer
GUC46_RS15220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GUC46_RS15225	COG2995	paraquat-inducible protein a
GUC46_RS15230	COG0488	(ABC) transporter
GUC46_RS15240	COG0633	Ferredoxin
GUC46_RS15240	COG3217	Mosc domain protein beta barrel domain protein
GUC46_RS15255	COG0431	NADPH-dependent FMN reductase
GUC46_RS15260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GUC46_RS15270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GUC46_RS15275	COG1116	anion transmembrane transporter activity
GUC46_RS15280	COG0308	aminopeptidase N
GUC46_RS15300	COG1448	Aminotransferase
GUC46_RS15305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GUC46_RS15310	COG3108	Peptidase M15
GUC46_RS15315	COG2989	Protein conserved in bacteria
GUC46_RS15325	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GUC46_RS15335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GUC46_RS15340	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GUC46_RS15345	COG3173	Aminoglycoside phosphotransferase
GUC46_RS15360	COG3214	Protein conserved in bacteria
GUC46_RS15375	COG2333	competence protein COMEC
GUC46_RS15375	COG0658	competence protein
GUC46_RS15385	COG0539	negative regulation of cytoplasmic translation
GUC46_RS15395	COG0501	Belongs to the peptidase M48B family
GUC46_RS15410	COG2323	membrane
GUC46_RS15415	COG1944	ATP diphosphatase activity
GUC46_RS15420	COG2116	formate transmembrane transporter activity
GUC46_RS15425	COG1882	Formate acetyltransferase
GUC46_RS15430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GUC46_RS15435	COG0531	amino acid
GUC46_RS15445	COG1335	isochorismatase
GUC46_RS15450	COG3302	dmso reductase anchor subunit
GUC46_RS15455	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS15460	COG0243	molybdopterin cofactor binding
GUC46_RS15470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GUC46_RS15480	COG1178	ABC-type Fe3 transport system permease component
GUC46_RS15480	COG1674	ftsk spoiiie
GUC46_RS15490	COG0492	ferredoxin-NADP+ reductase activity
GUC46_RS15495	COG4988	ABC transporter
GUC46_RS15500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GUC46_RS15515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GUC46_RS15520	COG0583	DNA-binding transcription factor activity
GUC46_RS15530	COG1335	isochorismatase
GUC46_RS15560	COG1177	transmembrane transport
GUC46_RS15565	COG1176	ABC-type spermidine putrescine transport system, permease component I
GUC46_RS15570	COG3842	ATPase activity
GUC46_RS15575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GUC46_RS15600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GUC46_RS15630	COG0583	DNA-binding transcription factor activity
GUC46_RS15635	COG3226	Transcriptional regulator
GUC46_RS15640	COG0738	Major facilitator superfamily
GUC46_RS15645	COG0561	phosphatase activity
GUC46_RS15655	COG2814	Major facilitator Superfamily
GUC46_RS15660	COG0671	phosphoesterase, PA-phosphatase related
GUC46_RS15665	COG1349	DNA-binding transcription factor activity
GUC46_RS15670	COG1686	Belongs to the peptidase S11 family
GUC46_RS15675	COG0625	glutathione transferase activity
GUC46_RS15680	COG2133	pyrroloquinoline quinone binding
GUC46_RS15695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GUC46_RS15715	COG1446	asparaginase
GUC46_RS15725	COG0303	'Molybdopterin
GUC46_RS15730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GUC46_RS15735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GUC46_RS15740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GUC46_RS15750	COG0561	phosphatase activity
GUC46_RS15760	COG0488	(ABC) transporter
GUC46_RS15765	COG1376	ErfK ybiS ycfS ynhG family protein
GUC46_RS15770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GUC46_RS15775	COG1321	iron dependent repressor
GUC46_RS15785	COG2194	sulfuric ester hydrolase activity
GUC46_RS15790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GUC46_RS15805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GUC46_RS15810	COG0765	amino acid transport
GUC46_RS15815	COG1126	abc transporter atp-binding protein
GUC46_RS15820	COG0668	transmembrane transport
GUC46_RS15835	COG4774	siderophore transport
GUC46_RS15845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GUC46_RS15855	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GUC46_RS15860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GUC46_RS15870	COG0513	Belongs to the DEAD box helicase family
GUC46_RS15875	COG1309	transcriptional regulator
GUC46_RS15885	COG1131	(ABC) transporter
GUC46_RS15890	COG0842	Transport permease protein
GUC46_RS15895	COG0842	Transport permease protein
GUC46_RS15905	COG3568	Endonuclease Exonuclease Phosphatase
GUC46_RS15910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GUC46_RS15915	COG0392	lysyltransferase activity
GUC46_RS15920	COG0670	Belongs to the BI1 family
GUC46_RS15925	COG0314	molybdopterin synthase activity
GUC46_RS15930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GUC46_RS15940	COG0521	Mo-molybdopterin cofactor biosynthetic process
GUC46_RS15970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GUC46_RS15995	COG1881	PFAM PEBP family protein
GUC46_RS16025	COG4677	pectinesterase activity
GUC46_RS16030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GUC46_RS16035	COG0471	metal ion transport
GUC46_RS16040	COG2828	Protein conserved in bacteria
GUC46_RS16045	COG0583	DNA-binding transcription factor activity
GUC46_RS16055	COG0561	phosphatase activity
GUC46_RS16065	COG4149	molybdate abc transporter
GUC46_RS16070	COG0725	ABC transporter, periplasmic molybdate-binding protein
GUC46_RS16080	COG3585	molybdate ion transport
GUC46_RS16080	COG2005	Transcriptional regulator
GUC46_RS16085	COG1119	ATPase activity
GUC46_RS16090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GUC46_RS16095	COG1085	galactose-1-phosphate uridylyltransferase
GUC46_RS16105	COG2017	converts alpha-aldose to the beta-anomer
GUC46_RS16115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GUC46_RS16125	COG1230	cation diffusion facilitator family transporter
GUC46_RS16130	COG3201	nicotinamide mononucleotide transporter
GUC46_RS16170	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GUC46_RS16175	COG2885	chlorophyll binding
GUC46_RS16185	COG3064	Membrane
GUC46_RS16190	COG0848	biopolymer transport protein
GUC46_RS16195	COG0811	peptide transport
GUC46_RS16200	COG0824	Thioesterase
GUC46_RS16205	COG3790	cyd operon protein YbgE
GUC46_RS16210	COG4890	Cyd operon protein YbgT
GUC46_RS16215	COG1294	oxidase, subunit
GUC46_RS16220	COG1271	oxidase subunit
GUC46_RS16225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GUC46_RS16235	COG4865	methylaspartate mutase activity
GUC46_RS16240	COG3799	methylaspartate ammonia-lyase activity
GUC46_RS16255	COG1301	dicarboxylic acid transport
GUC46_RS16265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GUC46_RS16265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GUC46_RS16275	COG0583	DNA-binding transcription factor activity
GUC46_RS16280	COG1648	precorrin-2 dehydrogenase activity
GUC46_RS16280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GUC46_RS16290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GUC46_RS16300	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUC46_RS16305	COG0567	Dehydrogenase, E1 component
GUC46_RS16310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GUC46_RS16315	COG1053	succinate dehydrogenase
GUC46_RS16320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GUC46_RS16325	COG2009	succinate dehydrogenase
GUC46_RS16355	COG3180	Ammonia monooxygenase
GUC46_RS16390	COG1984	allophanate hydrolase subunit 2
GUC46_RS16395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GUC46_RS16400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GUC46_RS16410	COG5464	transposase or invertase
GUC46_RS16420	COG3272	Protein of unknown function (DUF1722)
GUC46_RS16450	COG2205	protein histidine kinase activity
GUC46_RS16455	COG0745	RESPONSE REGULATOR receiver
GUC46_RS16460	COG0033	Phosphoglucomutase
GUC46_RS16465	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GUC46_RS16470	COG0596	Alpha beta hydrolase
GUC46_RS16480	COG0716	FMN binding
GUC46_RS16490	COG0735	belongs to the Fur family
GUC46_RS16495	COG0583	DNA-binding transcription factor activity
GUC46_RS16500	COG1053	succinate dehydrogenase
GUC46_RS16530	COG2190	(PTS) system
GUC46_RS16530	COG1263	PTS System
GUC46_RS16530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS16540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GUC46_RS16545	COG1846	Transcriptional regulator
GUC46_RS16545	COG1940	carbohydrate kinase activity
GUC46_RS16550	COG0647	UMP catabolic process
GUC46_RS16555	COG0367	asparagine synthase
GUC46_RS16595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GUC46_RS16605	COG1702	phosphate starvation-inducible protein PhoH
GUC46_RS16615	COG4535	Mg2 and Co2 transporter CorC
GUC46_RS16630	COG0765	amino acid transport
GUC46_RS16635	COG0765	amino acid transport
GUC46_RS16640	COG1126	abc transporter atp-binding protein
GUC46_RS16650	COG2888	peptidyl-tyrosine sulfation
GUC46_RS16665	COG1466	dna polymerase III delta subunit
GUC46_RS16675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GUC46_RS16685	COG0799	negative regulation of ribosome biogenesis
GUC46_RS16695	COG0768	penicillin binding
GUC46_RS16700	COG0772	Belongs to the SEDS family
GUC46_RS16705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GUC46_RS16710	COG1686	Belongs to the peptidase S11 family
GUC46_RS16735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GUC46_RS16745	COG1278	Cold shock
GUC46_RS16755	COG3069	C4-dicarboxylate transmembrane transporter activity
GUC46_RS16760	COG4565	transcriptional regulatory protein
GUC46_RS16765	COG3290	protein histidine kinase activity
GUC46_RS16770	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GUC46_RS16780	COG2301	Belongs to the HpcH HpaI aldolase family
GUC46_RS16785	COG3051	citrate lyase alpha subunit
GUC46_RS16800	COG0471	metal ion transport
GUC46_RS16805	COG3719	Belongs to the RNase T2 family
GUC46_RS16820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GUC46_RS16825	COG0589	response to stress
GUC46_RS16840	COG0243	molybdopterin cofactor binding
GUC46_RS16850	COG3634	alkyl hydroperoxide reductase activity
GUC46_RS16855	COG0450	alkyl hydroperoxide reductase
GUC46_RS16860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GUC46_RS16865	COG0583	DNA-binding transcription factor activity
GUC46_RS16870	COG3969	phosphoadenosine phosphosulfate
GUC46_RS16875	COG1475	DNA binding
GUC46_RS16880	COG0436	Aminotransferase
GUC46_RS16885	COG0371	Dehydrogenase
GUC46_RS16890	COG2879	small protein
GUC46_RS16895	COG1966	Carbon starvation protein
GUC46_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS16915	COG3433	isochorismatase activity
GUC46_RS16915	COG1535	isochorismatase
GUC46_RS16920	COG1021	2,3-dihydroxybenzoate-AMP ligase
GUC46_RS16925	COG1169	isochorismate synthase
GUC46_RS16930	COG4592	Periplasmic binding protein
GUC46_RS16940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUC46_RS16945	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUC46_RS16950	COG1120	ATPase activity
GUC46_RS16955	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GUC46_RS16960	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GUC46_RS16960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GUC46_RS16965	COG3251	PFAM MbtH domain protein
GUC46_RS16970	COG2382	esterase
GUC46_RS16975	COG4771	TonB-dependent receptor
GUC46_RS17015	COG2315	Protein conserved in bacteria
GUC46_RS17025	COG0668	transmembrane transport
GUC46_RS17030	COG1113	amino acid transport
GUC46_RS17060	COG5001	Diguanylate cyclase
GUC46_RS17060	COG3300	MHYT domain
GUC46_RS17075	COG3059	membrane
GUC46_RS17085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUC46_RS17090	COG2207	Transcriptional regulator
GUC46_RS17095	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUC46_RS17100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS17105	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS17110	COG1538	Outer membrane efflux protein
GUC46_RS17115	COG0745	RESPONSE REGULATOR receiver
GUC46_RS17120	COG5002	protein histidine kinase activity
GUC46_RS17135	COG0321	lipoyl(octanoyl) transferase activity
GUC46_RS17135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GUC46_RS17140	COG0243	molybdopterin cofactor binding
GUC46_RS17145	COG3005	denitrification pathway
GUC46_RS17150	COG0589	response to stress
GUC46_RS17165	COG3005	denitrification pathway
GUC46_RS17170	COG0745	RESPONSE REGULATOR receiver
GUC46_RS17175	COG1879	ABC-type sugar transport system periplasmic component
GUC46_RS17180	COG2198	Histidine kinase
GUC46_RS17180	COG2205	protein histidine kinase activity
GUC46_RS17180	COG0784	Response regulator, receiver
GUC46_RS17245	COG2501	S4 domain
GUC46_RS17250	COG1988	membrane-bound metal-dependent
GUC46_RS17260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GUC46_RS17270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GUC46_RS17275	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GUC46_RS17295	COG1464	Belongs to the NlpA lipoprotein family
GUC46_RS17300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GUC46_RS17305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GUC46_RS17310	COG4181	ATPase activity
GUC46_RS17315	COG2755	lipolytic protein G-D-S-L family
GUC46_RS17320	COG0300	oxidoreductase activity
GUC46_RS17325	COG3118	belongs to the thioredoxin family
GUC46_RS17330	COG0390	transport system, permease component
GUC46_RS17335	COG4619	ABC transporter
GUC46_RS17340	COG0330	HflC and HflK could
GUC46_RS17345	COG1585	Membrane protein implicated in regulation of membrane protease activity
GUC46_RS17365	COG4771	TonB-dependent receptor
GUC46_RS17370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GUC46_RS17380	COG3721	Heme iron utilization protein
GUC46_RS17390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GUC46_RS17405	COG3735	TraB family
GUC46_RS17410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GUC46_RS17420	COG2223	nitrite transmembrane transporter activity
GUC46_RS17425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GUC46_RS17425	COG4651	solute:proton antiporter activity
GUC46_RS17430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS17475	COG2832	Protein of unknown function (DUF454)
GUC46_RS17480	COG3923	Primosomal replication protein n
GUC46_RS17490	COG3264	Mechanosensitive ion channel
GUC46_RS17490	COG1196	nuclear chromosome segregation
GUC46_RS17495	COG1309	transcriptional regulator
GUC46_RS17500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GUC46_RS17505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUC46_RS17520	COG0110	maltose O-acetyltransferase activity
GUC46_RS17540	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GUC46_RS17545	COG5507	3-demethylubiquinone-9 3-methyltransferase
GUC46_RS17550	COG2364	Membrane
GUC46_RS17555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GUC46_RS17575	COG3695	enzyme binding
GUC46_RS17580	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GUC46_RS17585	COG1946	Acyl-CoA thioesterase
GUC46_RS17590	COG0004	ammonium transporteR
GUC46_RS17595	COG0347	Belongs to the P(II) protein family
GUC46_RS17600	COG1132	(ABC) transporter
GUC46_RS17605	COG1132	(ABC) transporter
GUC46_RS17610	COG1522	sequence-specific DNA binding
GUC46_RS17625	COG4533	DNA binding
GUC46_RS17635	COG0824	Thioesterase
GUC46_RS17640	COG1555	photosystem II stabilization
GUC46_RS17645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GUC46_RS17650	COG0776	regulation of translation
GUC46_RS17655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GUC46_RS17675	COG0271	Belongs to the BolA IbaG family
GUC46_RS17680	COG3056	Lipoprotein
GUC46_RS17685	COG2223	nitrite transmembrane transporter activity
GUC46_RS17690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GUC46_RS17695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GUC46_RS17700	COG1845	cytochrome c oxidase, subunit III
GUC46_RS17705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GUC46_RS17715	COG2814	Major facilitator Superfamily
GUC46_RS17750	COG0142	geranyltranstransferase activity
GUC46_RS17755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GUC46_RS17760	COG0667	Aldo Keto reductase
GUC46_RS17765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GUC46_RS17770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GUC46_RS17785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GUC46_RS17785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GUC46_RS17795	COG4238	major outer membrane lipoprotein
GUC46_RS17800	COG3248	Nucleoside-binding outer membrane protein
GUC46_RS17815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GUC46_RS17820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GUC46_RS17825	COG1862	Preprotein translocase
GUC46_RS17845	COG0450	alkyl hydroperoxide reductase
GUC46_RS17860	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GUC46_RS17870	COG1335	isochorismatase
GUC46_RS17875	COG0583	DNA-binding transcription factor activity
GUC46_RS17880	COG0366	Alpha amylase catalytic
GUC46_RS17890	COG1114	Component of the transport system for branched-chain amino acids
GUC46_RS17895	COG5002	protein histidine kinase activity
GUC46_RS17905	COG0420	3'-5' exonuclease activity
GUC46_RS17910	COG0419	ATPase involved in DNA repair
GUC46_RS17915	COG2814	Major facilitator Superfamily
GUC46_RS17920	COG1940	carbohydrate kinase activity
GUC46_RS17935	COG4126	flavin adenine dinucleotide binding
GUC46_RS17955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GUC46_RS17960	COG3706	GGDEF domain
GUC46_RS17970	COG1785	Belongs to the alkaline phosphatase family
GUC46_RS17985	COG1181	Belongs to the D-alanine--D-alanine ligase family
GUC46_RS18005	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GUC46_RS18010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GUC46_RS18015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GUC46_RS18025	COG0113	porphobilinogen synthase activity
GUC46_RS18030	COG2175	clavaminate synthase activity
GUC46_RS18035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GUC46_RS18040	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GUC46_RS18045	COG4521	taurine ABC transporter
GUC46_RS18060	COG2271	Major facilitator Superfamily
GUC46_RS18065	COG1840	ABC-type Fe3 transport system, periplasmic component
GUC46_RS18075	COG3842	ATPase activity
GUC46_RS18080	COG2040	homocysteine
GUC46_RS18085	COG0833	amino acid
GUC46_RS18090	COG2814	Major facilitator Superfamily
GUC46_RS18115	COG3384	dioxygenase
GUC46_RS18125	COG1414	Transcriptional regulator
GUC46_RS18155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GUC46_RS18170	COG1609	Transcriptional regulator
GUC46_RS18195	COG2079	MmgE PrpD family protein
GUC46_RS18200	COG0372	Belongs to the citrate synthase family
GUC46_RS18210	COG3829	transcription factor binding
GUC46_RS18220	COG1280	lysine exporter protein (LysE YggA)
GUC46_RS18225	COG3706	GGDEF domain
GUC46_RS18230	COG0348	domain, Protein
GUC46_RS18250	COG0583	DNA-binding transcription factor activity
GUC46_RS18270	COG3069	C4-dicarboxylate transmembrane transporter activity
GUC46_RS18275	COG2195	Cleaves the N-terminal amino acid of tripeptides
GUC46_RS18285	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GUC46_RS18290	COG0693	protein deglycase activity
GUC46_RS18300	COG2200	EAL domain
GUC46_RS18310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GUC46_RS18315	COG0531	amino acid
GUC46_RS18320	COG0174	glutamine synthetase
GUC46_RS18325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GUC46_RS18330	COG1396	sequence-specific DNA binding
GUC46_RS18330	COG1917	Cupin 2, conserved barrel domain protein
GUC46_RS18335	COG1012	belongs to the aldehyde dehydrogenase family
GUC46_RS18340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GUC46_RS18355	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
GUC46_RS18360	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GUC46_RS18365	COG1999	signal sequence binding
GUC46_RS18370	COG1773	rubredoxin
GUC46_RS18375	COG1271	oxidase subunit
GUC46_RS18380	COG1294	oxidase, subunit
GUC46_RS18405	COG1609	Transcriptional regulator
GUC46_RS18410	COG1757	Na H antiporter
GUC46_RS18415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GUC46_RS18475	COG0582	viral genome integration into host DNA
GUC46_RS18480	COG0582	viral genome integration into host DNA
GUC46_RS18565	COG0071	Belongs to the small heat shock protein (HSP20) family
GUC46_RS18570	COG0542	response to heat
GUC46_RS18580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GUC46_RS18625	COG0501	Belongs to the peptidase M48B family
GUC46_RS18630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GUC46_RS18650	COG3596	GTP binding
GUC46_RS18660	COG2378	regulation of single-species biofilm formation
GUC46_RS18685	COG4325	translation initiation factor activity
GUC46_RS18690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GUC46_RS18695	COG2826	transposase and inactivated derivatives, IS30 family
GUC46_RS18710	COG2003	Belongs to the UPF0758 family
GUC46_RS18740	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GUC46_RS18780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GUC46_RS18790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GUC46_RS18815	COG2195	Cleaves the N-terminal amino acid of tripeptides
GUC46_RS18835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GUC46_RS18840	COG1191	sigma factor activity
GUC46_RS18865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GUC46_RS18870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GUC46_RS18890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GUC46_RS18895	COG1256	bacterial-type flagellum assembly
GUC46_RS18895	COG4786	Flagellar basal body rod
GUC46_RS18915	COG4786	Flagellar basal body rod
GUC46_RS18920	COG4787	bacterial-type flagellum-dependent cell motility
GUC46_RS18935	COG1558	bacterial-type flagellum-dependent cell motility
GUC46_RS18980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GUC46_RS19000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GUC46_RS19010	COG1677	Flagellar hook-basal body complex protein FliE
GUC46_RS19035	COG1987	bacterial-type flagellum assembly
GUC46_RS19040	COG1684	flagellar biosynthetic protein fliR
GUC46_RS19055	COG0791	NLP P60 protein
GUC46_RS19060	COG3034	peptidoglycan biosynthetic process
GUC46_RS19065	COG0121	glutamine amidotransferase
GUC46_RS19075	COG1960	acyl-CoA dehydrogenase activity
GUC46_RS19080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GUC46_RS19090	COG2200	EAL domain
GUC46_RS19105	COG3539	Fimbrial protein
GUC46_RS19115	COG3121	Chaperone
GUC46_RS19120	COG3188	usher protein
GUC46_RS19130	COG3539	Fimbrial protein
GUC46_RS19135	COG0745	RESPONSE REGULATOR receiver
GUC46_RS19150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GUC46_RS19160	COG2226	methyltransferase
GUC46_RS19170	COG0741	lytic transglycosylase activity
GUC46_RS19170	COG1388	LysM domain
GUC46_RS19175	COG2226	methyltransferase
GUC46_RS19185	COG2814	Major facilitator Superfamily
GUC46_RS19190	COG0583	DNA-binding transcription factor activity
GUC46_RS19225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GUC46_RS19235	COG2011	ABC-type metal ion transport system permease component
GUC46_RS19240	COG1464	Belongs to the NlpA lipoprotein family
GUC46_RS19250	COG1720	tRNA m6t6A37 methyltransferase activity
GUC46_RS19260	COG3015	lipoprotein NlpE involved in copper resistance
GUC46_RS19265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GUC46_RS19270	COG4681	YaeQ
GUC46_RS19280	COG4568	rho-dependent transcription termination
GUC46_RS19290	COG0346	lactoylglutathione lyase activity
GUC46_RS19330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GUC46_RS19335	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GUC46_RS19350	COG0575	Belongs to the CDS family
GUC46_RS19360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GUC46_RS19385	COG0024	Methionine aminopeptidase
GUC46_RS19405	COG3835	regulator
GUC46_RS19430	COG2860	membrane
GUC46_RS19455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GUC46_RS19460	COG1120	ATPase activity
GUC46_RS19465	COG4774	siderophore transport
GUC46_RS19470	COG3539	Fimbrial protein
GUC46_RS19475	COG3188	usher protein
GUC46_RS19480	COG3121	Chaperone
GUC46_RS19490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GUC46_RS19495	COG1643	Atp-dependent helicase
GUC46_RS19500	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GUC46_RS19510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GUC46_RS19520	COG0617	tRNA 3'-terminal CCA addition
GUC46_RS19525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GUC46_RS19530	COG3539	Fimbrial protein
GUC46_RS19535	COG3121	Chaperone
GUC46_RS19555	COG3539	Fimbrial protein
GUC46_RS19565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GUC46_RS19585	COG3121	Chaperone
GUC46_RS19590	COG3188	usher protein
GUC46_RS19610	COG0726	polysaccharide deacetylase
GUC46_RS19615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS19620	COG0842	Transport permease protein
GUC46_RS19625	COG1131	(ABC) transporter
GUC46_RS19630	COG0288	reversible hydration of carbon dioxide
GUC46_RS19635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GUC46_RS19685	COG3064	Membrane
GUC46_RS19700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GUC46_RS19705	COG0508	dehydrogenase complex catalyzes the overall conversion of
GUC46_RS19710	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GUC46_RS19715	COG2186	Transcriptional regulator
GUC46_RS19725	COG2211	Major facilitator Superfamily
GUC46_RS19730	COG3940	Belongs to the glycosyl hydrolase 43 family
GUC46_RS19735	COG3725	Membrane protein required for beta-lactamase induction
GUC46_RS19750	COG4969	Belongs to the N-Me-Phe pilin family
GUC46_RS19755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GUC46_RS19760	COG1459	type II secretion system
GUC46_RS19770	COG0237	dephospho-CoA kinase activity
GUC46_RS19785	COG0494	nUDIX hydrolase
GUC46_RS19805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GUC46_RS19810	COG0849	cell division
GUC46_RS19820	COG1181	Belongs to the D-alanine--D-alanine ligase family
GUC46_RS19835	COG0772	Belongs to the SEDS family
GUC46_RS19840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GUC46_RS19850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GUC46_RS19855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GUC46_RS19860	COG0768	penicillin binding
GUC46_RS19880	COG1609	Transcriptional regulator
GUC46_RS19890	COG0028	Belongs to the TPP enzyme family
GUC46_RS19925	COG1609	Transcriptional regulator
GUC46_RS19935	COG1028	Short-chain dehydrogenase reductase Sdr
GUC46_RS19940	COG2814	Major facilitator Superfamily
GUC46_RS19955	COG4143	(ABC) transporter
GUC46_RS19960	COG1178	ABC-type Fe3 transport system permease component
GUC46_RS19970	COG0586	Pfam SNARE associated Golgi protein
GUC46_RS20000	COG0235	Class ii aldolase
GUC46_RS20010	COG0417	DNA replication proofreading
GUC46_RS20020	COG0564	pseudouridine synthase activity
GUC46_RS20030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GUC46_RS20080	COG2271	Major facilitator Superfamily
GUC46_RS20090	COG0644	oxidoreductase
GUC46_RS20145	COG0505	Belongs to the CarA family
GUC46_RS20165	COG1047	Peptidyl-prolyl cis-trans
GUC46_RS20180	COG0196	riboflavin kinase activity
GUC46_RS20205	COG0583	DNA-binding transcription factor activity
GUC46_RS20220	COG0443	Heat shock 70 kDa protein
GUC46_RS20230	COG4735	regulation of single-species biofilm formation
GUC46_RS20235	COG1584	GPR1 FUN34 yaaH family protein
GUC46_RS20245	COG0521	Mo-molybdopterin cofactor biosynthetic process
GUC46_RS20255	COG1115	amino acid carrier protein
GUC46_RS20265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GUC46_RS20275	COG0460	homoserine dehydrogenase
GUC46_RS20275	COG0527	aspartate kinase activity
GUC46_RS20285	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GUC46_RS20295	COG0745	RESPONSE REGULATOR receiver
GUC46_RS20300	COG4452	Inner membrane protein CreD
GUC46_RS20305	COG2205	protein histidine kinase activity
GUC46_RS20310	COG0745	RESPONSE REGULATOR receiver
GUC46_RS20315	COG3045	CreA protein
GUC46_RS20320	COG3708	Transcriptional regulator
GUC46_RS20320	COG2207	Transcriptional regulator
GUC46_RS20340	COG0741	lytic transglycosylase activity
GUC46_RS20345	COG0488	(ABC) transporter
GUC46_RS20360	COG0560	Phosphoserine phosphatase
GUC46_RS20395	COG1328	CTP reductase activity
GUC46_RS20400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GUC46_RS20405	COG0084	hydrolase, TatD family'
GUC46_RS20415	COG5487	UPF0391 membrane protein
GUC46_RS20420	COG2823	Periplasmic or secreted lipoprotein
GUC46_RS20430	COG1011	Hydrolase
GUC46_RS20435	COG0456	acetyltransferase
GUC46_RS20440	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
GUC46_RS20470	COG3706	GGDEF domain
GUC46_RS20475	COG4114	ferric iron reductase
GUC46_RS20480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GUC46_RS20485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GUC46_RS20490	COG2197	response regulator
GUC46_RS20495	COG2197	response regulator
GUC46_RS20500	COG2966	Psort location CytoplasmicMembrane, score
GUC46_RS20515	COG1484	DNA-dependent DNA replication
GUC46_RS20535	COG1063	alcohol dehydrogenase
GUC46_RS20540	COG1802	Transcriptional regulator
GUC46_RS20545	COG2271	Major facilitator Superfamily
GUC46_RS20555	COG0840	transmembrane signaling receptor activity
GUC46_RS20565	COG1966	Carbon starvation protein
GUC46_RS20570	COG2879	small protein
GUC46_RS20575	COG0523	cobalamin synthesis protein
GUC46_RS20585	COG1566	PFAM secretion protein HlyD family protein
GUC46_RS20595	COG5457	Domain of unknown function (DUF1127)
GUC46_RS20600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GUC46_RS20620	COG2814	Major facilitator Superfamily
GUC46_RS20625	COG0626	cystathionine gamma-synthase activity
GUC46_RS20630	COG1301	dicarboxylic acid transport
GUC46_RS20635	COG0583	DNA-binding transcription factor activity
GUC46_RS20640	COG2733	membrane
GUC46_RS20650	COG0477	Major facilitator Superfamily
GUC46_RS20670	COG2186	Transcriptional regulator
GUC46_RS20675	COG0246	Mannitol dehydrogenase
GUC46_RS20685	COG2610	gluconate transmembrane transporter activity
GUC46_RS20690	COG1556	Lactate utilization protein
GUC46_RS20695	COG1139	Iron-sulfur cluster binding protein
GUC46_RS20700	COG0247	lactate metabolic process
GUC46_RS20705	COG1620	l-lactate permease
GUC46_RS20745	COG1715	Restriction endonuclease
GUC46_RS20760	COG2003	Belongs to the UPF0758 family
GUC46_RS20785	COG3596	GTP binding
GUC46_RS20845	COG0210	DNA helicase
GUC46_RS20850	COG1111	helicase
GUC46_RS20850	COG1205	dead DEAH box helicase
GUC46_RS20860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GUC46_RS20890	COG0582	viral genome integration into host DNA
GUC46_RS20945	COG1064	alcohol dehydrogenase
GUC46_RS20950	COG0433	COG0433 Predicted ATPase
GUC46_RS20955	COG0795	lipopolysaccharide-transporting ATPase activity
GUC46_RS20960	COG0795	lipopolysaccharide-transporting ATPase activity
GUC46_RS20970	COG2927	DNA polymerase III (CHI subunit)
GUC46_RS20975	COG0525	valine-tRNA ligase activity
GUC46_RS20980	COG4269	membrane
GUC46_RS21000	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GUC46_RS21010	COG2731	YhcH YjgK YiaL family protein
GUC46_RS21015	COG2235	arginine
GUC46_RS21025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GUC46_RS21030	COG1288	antiporter activity
GUC46_RS21035	COG1438	arginine binding
GUC46_RS21080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GUC46_RS21095	COG1263	PTS System
GUC46_RS21095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GUC46_RS21100	COG0366	Alpha amylase catalytic
GUC46_RS21110	COG1737	Transcriptional regulator
GUC46_RS21120	COG0383	alpha-mannosidase activity
GUC46_RS21125	COG0366	Alpha amylase catalytic
GUC46_RS21130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS21130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GUC46_RS21130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS21145	COG2026	Addiction module toxin, RelE StbE family
GUC46_RS21150	COG3077	Addiction module antitoxin, RelB DinJ family
GUC46_RS21155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GUC46_RS21155	COG3711	transcriptional antiterminator
GUC46_RS21170	COG3964	amidohydrolase
GUC46_RS21200	COG3783	Cytochrome b(562)
GUC46_RS21205	COG0312	modulator of DNA gyrase
GUC46_RS21215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GUC46_RS21225	COG0840	transmembrane signaling receptor activity
GUC46_RS21230	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS21235	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS21240	COG1129	ABC transporter
GUC46_RS21245	COG1879	ABC-type sugar transport system periplasmic component
GUC46_RS21250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GUC46_RS21260	COG3157	Type VI secretion system effector, Hcp
GUC46_RS21265	COG2105	PFAM AIG2 family protein
GUC46_RS21270	COG2911	Protein conserved in bacteria
GUC46_RS21275	COG0729	surface antigen
GUC46_RS21285	COG1609	Transcriptional regulator
GUC46_RS21290	COG0673	inositol 2-dehydrogenase activity
GUC46_RS21295	COG0673	inositol 2-dehydrogenase activity
GUC46_RS21300	COG0655	NAD(P)H dehydrogenase (quinone) activity
GUC46_RS21310	COG2211	Major facilitator Superfamily
GUC46_RS21320	COG1253	flavin adenine dinucleotide binding
GUC46_RS21330	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GUC46_RS21335	COG1218	3'(2'),5'-bisphosphate nucleotidase
GUC46_RS21345	COG1733	regulation of RNA biosynthetic process
GUC46_RS21350	COG0702	epimerase
GUC46_RS21360	COG0697	spore germination
GUC46_RS21365	COG0840	transmembrane signaling receptor activity
GUC46_RS21375	COG1113	amino acid transport
GUC46_RS21380	COG0545	Peptidyl-prolyl cis-trans isomerase
GUC46_RS21385	COG3061	Opacity-associated protein A
GUC46_RS21415	COG0730	response to heat
GUC46_RS21445	COG3414	Phosphotransferase system galactitol-specific IIB component
GUC46_RS21465	COG1073	alpha beta
GUC46_RS21470	COG3650	response to hydrogen peroxide
GUC46_RS21480	COG1960	acyl-CoA dehydrogenase activity
GUC46_RS21485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GUC46_RS21490	COG0557	exoribonuclease II activity
GUC46_RS21505	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GUC46_RS21510	COG0330	HflC and HflK could
GUC46_RS21515	COG0330	HflC and HflK could
GUC46_RS21520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GUC46_RS21525	COG1923	regulation of RNA biosynthetic process
GUC46_RS21540	COG0860	N-Acetylmuramoyl-L-alanine amidase
GUC46_RS21545	COG0802	atpase or kinase
GUC46_RS21550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GUC46_RS21550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GUC46_RS21555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GUC46_RS21590	COG3264	Mechanosensitive ion channel
GUC46_RS21590	COG1511	domain protein
GUC46_RS21595	COG0531	amino acid
GUC46_RS21605	COG1053	succinate dehydrogenase
GUC46_RS21610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GUC46_RS21665	COG1509	lysine 2,3-aminomutase activity
GUC46_RS21690	COG0531	amino acid
GUC46_RS21695	COG3030	protein affecting phage T7 exclusion by the F plasmid
GUC46_RS21700	COG1027	Aspartate ammonia-lyase
GUC46_RS21705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GUC46_RS21720	COG1309	transcriptional regulator
GUC46_RS21730	COG0318	PFAM AMP-dependent synthetase and ligase
GUC46_RS21755	COG3290	protein histidine kinase activity
GUC46_RS21760	COG4565	transcriptional regulatory protein
GUC46_RS21765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GUC46_RS21770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GUC46_RS21770	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GUC46_RS21775	COG3647	Membrane
GUC46_RS21785	COG2211	Major facilitator Superfamily
GUC46_RS21790	COG1486	melibiose metabolic process
GUC46_RS21795	COG2169	Transcriptional regulator
GUC46_RS21800	COG1982	Orn Lys Arg decarboxylase major
GUC46_RS21805	COG2207	Transcriptional regulator
GUC46_RS21810	COG0531	amino acid
GUC46_RS21850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GUC46_RS21855	COG2824	Alkylphosphonate utilization operon protein PhnA
GUC46_RS21860	COG2764	glyoxalase bleomycin resistance protein dioxygenase
GUC46_RS21865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GUC46_RS21870	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GUC46_RS21875	COG3639	organic phosphonate transmembrane transporter activity
GUC46_RS21880	COG2188	Transcriptional regulator
GUC46_RS21885	COG3624	Phosphonate C-P lyase system protein PhnG
GUC46_RS21890	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GUC46_RS21895	COG3626	phosphonate metabolism
GUC46_RS21900	COG3627	carbon phosphorus lyase activity
GUC46_RS21905	COG4107	phosphonate C-P lyase system protein PhnK
GUC46_RS21910	COG4778	phosphonate C-P lyase system protein PhnL
GUC46_RS21915	COG3454	Phosphonate metabolism
GUC46_RS21925	COG0456	acetyltransferase
GUC46_RS21930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GUC46_RS21945	COG1129	ABC transporter
GUC46_RS21950	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS21955	COG1879	ABC-type sugar transport system periplasmic component
GUC46_RS21980	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GUC46_RS21990	COG1566	PFAM secretion protein HlyD family protein
GUC46_RS21995	COG1289	transmembrane transporter activity
GUC46_RS22000	COG1538	Outer membrane efflux protein
GUC46_RS22010	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GUC46_RS22015	COG1301	dicarboxylic acid transport
GUC46_RS22020	COG4235	cytochrome complex assembly
GUC46_RS22025	COG3088	subunit of a heme lyase
GUC46_RS22030	COG1138	Cytochrome C-type biogenesis protein
GUC46_RS22035	COG3301	Polysulphide reductase, NrfD
GUC46_RS22040	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS22045	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GUC46_RS22060	COG3162	membrane
GUC46_RS22070	COG1346	cytolysis
GUC46_RS22075	COG1380	Effector of murein hydrolase LrgA
GUC46_RS22080	COG0583	DNA-binding transcription factor activity
GUC46_RS22085	COG1943	Transposase
GUC46_RS22090	COG0025	NhaP-type Na H and K H
GUC46_RS22095	COG2252	PERMEase
GUC46_RS22100	COG0789	Transcriptional regulator
GUC46_RS22110	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GUC46_RS22125	COG0629	single-stranded DNA binding
GUC46_RS22130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GUC46_RS22135	COG2315	Protein conserved in bacteria
GUC46_RS22140	COG3700	Belongs to the class B bacterial acid phosphatase family
GUC46_RS22145	COG1448	Aminotransferase
GUC46_RS22155	COG0305	Participates in initiation and elongation during chromosome replication
GUC46_RS22170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GUC46_RS22180	COG0735	belongs to the Fur family
GUC46_RS22185	COG3237	CsbD-like
GUC46_RS22190	COG0534	Mate efflux family protein
GUC46_RS22200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GUC46_RS22245	COG2182	Extracellular solute-binding protein
GUC46_RS22260	COG2814	Major facilitator Superfamily
GUC46_RS22260	COG0477	Major facilitator Superfamily
GUC46_RS22275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GUC46_RS22280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GUC46_RS22305	COG0527	aspartate kinase activity
GUC46_RS22310	COG3541	Predicted nucleotidyltransferase
GUC46_RS22320	COG4650	regulator
GUC46_RS22340	COG1187	pseudouridine synthase activity
GUC46_RS22380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GUC46_RS22385	COG2826	transposase and inactivated derivatives, IS30 family
GUC46_RS22395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GUC46_RS22410	COG0745	RESPONSE REGULATOR receiver
GUC46_RS22415	COG5002	protein histidine kinase activity
GUC46_RS22415	COG3850	Histidine kinase
GUC46_RS22435	COG0646	methionine synthase
GUC46_RS22435	COG1410	methionine synthase
GUC46_RS22445	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GUC46_RS22455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GUC46_RS22465	COG0456	acetyltransferase
GUC46_RS22490	COG0151	Belongs to the GarS family
GUC46_RS22500	COG4191	Histidine kinase
GUC46_RS22520	COG0776	regulation of translation
GUC46_RS22525	COG3068	Protein conserved in bacteria
GUC46_RS22560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GUC46_RS22565	COG2104	thiamine diphosphate biosynthetic process
GUC46_RS22580	COG1278	Cold shock
GUC46_RS22590	COG1447	Phosphotransferase system cellobiose-specific component IIA
GUC46_RS22625	COG0250	Participates in transcription elongation, termination and antitermination
GUC46_RS22630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GUC46_RS22670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GUC46_RS22730	COG0583	DNA-binding transcription factor activity
GUC46_RS22765	COG2207	Transcriptional regulator
GUC46_RS22775	COG0371	Dehydrogenase
GUC46_RS22785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GUC46_RS22790	COG0583	DNA-binding transcription factor activity
GUC46_RS22800	COG0737	Belongs to the 5'-nucleotidase family
GUC46_RS22810	COG0460	homoserine dehydrogenase
GUC46_RS22810	COG0527	aspartate kinase activity
GUC46_RS22815	COG0626	cystathionine gamma-synthase activity
GUC46_RS22825	COG2211	Major facilitator Superfamily
GUC46_RS22830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GUC46_RS22840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GUC46_RS22845	COG1609	Transcriptional regulator
GUC46_RS22850	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GUC46_RS22865	COG1575	Belongs to the MenA family. Type 1 subfamily
GUC46_RS22880	COG3074	FtsZ-dependent cytokinesis
GUC46_RS22885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GUC46_RS22895	COG1494	fructose-1,6-bisphosphatase
GUC46_RS22905	COG3152	Membrane
GUC46_RS22920	COG0471	metal ion transport
GUC46_RS22935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GUC46_RS22950	COG3678	ATP-independent chaperone mediated protein folding
GUC46_RS22955	COG0745	RESPONSE REGULATOR receiver
GUC46_RS22960	COG2205	protein histidine kinase activity
GUC46_RS22965	COG2258	MOSC domain
GUC46_RS22970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GUC46_RS23015	COG1454	alcohol dehydrogenase
GUC46_RS23030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GUC46_RS23055	COG0437	4 iron, 4 sulfur cluster binding
GUC46_RS23060	COG2864	formate dehydrogenase
GUC46_RS23075	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GUC46_RS23085	COG0456	acetyltransferase
GUC46_RS23100	COG1011	Hydrolase
GUC46_RS23110	COG0477	Major facilitator Superfamily
GUC46_RS23120	COG1063	alcohol dehydrogenase
GUC46_RS23125	COG3684	Belongs to the aldolase LacD family
GUC46_RS23130	COG2084	Dehydrogenase
GUC46_RS23135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS23140	COG1349	DNA-binding transcription factor activity
GUC46_RS23150	COG0174	glutamine synthetase
GUC46_RS23155	COG3852	Histidine kinase
GUC46_RS23160	COG2204	response regulator
GUC46_RS23170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GUC46_RS23190	COG0204	Acyl-transferase
GUC46_RS23205	COG3084	Protein conserved in bacteria
GUC46_RS23210	COG0746	molybdenum cofactor guanylyltransferase activity
GUC46_RS23215	COG1763	Mo-molybdopterin cofactor biosynthetic process
GUC46_RS23255	COG1739	Uncharacterized protein family UPF0029
GUC46_RS23275	COG1609	Transcriptional regulator
GUC46_RS23280	COG1940	carbohydrate kinase activity
GUC46_RS23305	COG0805	protein transport
GUC46_RS23315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GUC46_RS23335	COG1322	Protein conserved in bacteria
GUC46_RS23340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GUC46_RS23355	COG0583	DNA-binding transcription factor activity
GUC46_RS23365	COG0561	phosphatase activity
GUC46_RS23370	COG2267	carboxylic ester hydrolase activity
GUC46_RS23375	COG1280	lysine exporter protein (LysE YggA)
GUC46_RS23385	COG1280	lysine exporter protein (LysE YggA)
GUC46_RS23395	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GUC46_RS23400	COG2050	protein possibly involved in aromatic compounds catabolism
GUC46_RS23420	COG1011	Hydrolase
GUC46_RS23440	COG5567	small periplasmic lipoprotein
GUC46_RS23450	COG3072	Adenylate cyclase
GUC46_RS23465	COG2959	enzyme of heme biosynthesis
GUC46_RS23470	COG3071	HemY protein
GUC46_RS23495	COG1113	amino acid transport
GUC46_RS23515	COG2244	polysaccharide biosynthetic process
GUC46_RS23520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GUC46_RS23525	COG0456	acetyltransferase
GUC46_RS23530	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GUC46_RS23535	COG1088	dTDP-glucose 4,6-dehydratase activity
GUC46_RS23540	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GUC46_RS23555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GUC46_RS23560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GUC46_RS23570	COG3118	belongs to the thioredoxin family
GUC46_RS23590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GUC46_RS23600	COG0583	DNA-binding transcription factor activity
GUC46_RS23610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GUC46_RS23620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GUC46_RS23625	COG3978	acetolactate synthase activity
GUC46_RS23645	COG3085	chromosome segregation
GUC46_RS23685	COG2186	Transcriptional regulator
GUC46_RS23690	COG0477	Major facilitator Superfamily
GUC46_RS23695	COG1609	Transcriptional regulator
GUC46_RS23700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GUC46_RS23705	COG1879	ABC-type sugar transport system periplasmic component
GUC46_RS23710	COG1172	Belongs to the binding-protein-dependent transport system permease family
GUC46_RS23720	COG1869	D-ribose catabolic process
GUC46_RS23740	COG2502	aspartate--ammonia ligase
GUC46_RS23745	COG1522	sequence-specific DNA binding
GUC46_RS23750	COG0716	FMN binding
GUC46_RS23765	COG3312	ion transport
GUC46_RS23790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GUC46_RS23800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GUC46_RS23805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GUC46_RS23825	COG3121	Chaperone
GUC46_RS23835	COG3539	Fimbrial protein
GUC46_RS23840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GUC46_RS23845	COG0573	inorganic phosphate transmembrane transporter activity
GUC46_RS23850	COG0581	inorganic phosphate transmembrane transporter activity
GUC46_RS23860	COG0704	Plays a role in the regulation of phosphate uptake
GUC46_RS23865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GUC46_RS23870	COG2252	PERMEase
GUC46_RS23875	COG0431	NADPH-dependent FMN reductase
GUC46_RS23880	COG2091	lysine biosynthetic process via aminoadipic acid
GUC46_RS23915	COG0230	Belongs to the bacterial ribosomal protein bL34 family