locus-tag	class	description
HV229_RS00010	COG0592	DNA-directed DNA polymerase activity
HV229_RS00025	COG0561	phosphatase activity
HV229_RS00030	COG0644	oxidoreductase
HV229_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV229_RS00040	COG5645	(Lipo)protein
HV229_RS00070	COG2149	membrane
HV229_RS00080	COG0641	radical SAM
HV229_RS00090	COG2610	gluconate transmembrane transporter activity
HV229_RS00095	COG0583	DNA-binding transcription factor activity
HV229_RS00105	COG2814	Major facilitator Superfamily
HV229_RS00125	COG0028	Belongs to the TPP enzyme family
HV229_RS00130	COG0440	acetolactate synthase activity
HV229_RS00135	COG1349	DNA-binding transcription factor activity
HV229_RS00145	COG0738	Major facilitator superfamily
HV229_RS00155	COG2197	response regulator
HV229_RS00185	COG2723	6-phospho-beta-galactosidase activity
HV229_RS00200	COG1464	Belongs to the NlpA lipoprotein family
HV229_RS00205	COG0697	spore germination
HV229_RS00215	COG0604	alcohol dehydrogenase
HV229_RS00220	COG0583	DNA-binding transcription factor activity
HV229_RS00230	COG3539	Fimbrial protein
HV229_RS00250	COG2197	response regulator
HV229_RS00270	COG2771	luxR family
HV229_RS00300	COG2211	Major facilitator Superfamily
HV229_RS00305	COG1501	Belongs to the glycosyl hydrolase 31 family
HV229_RS00310	COG3711	transcriptional antiterminator
HV229_RS00315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS00315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS00315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS00320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS00325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS00325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS00335	COG0191	fructose-bisphosphate aldolase activity
HV229_RS00345	COG2982	Protein involved in outer membrane biogenesis
HV229_RS00350	COG2233	PERMEase
HV229_RS00355	COG0786	glutamate:sodium symporter activity
HV229_RS00360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV229_RS00365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV229_RS00370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV229_RS00380	COG0194	GDP metabolic process
HV229_RS00390	COG2860	membrane
HV229_RS00395	COG1561	YicC-like family, N-terminal region
HV229_RS00420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV229_RS00435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV229_RS00450	COG1519	Transferase
HV229_RS00455	COG0438	transferase activity, transferring glycosyl groups
HV229_RS00460	COG0515	serine threonine protein kinase
HV229_RS00465	COG1442	glycosyl transferase family 8
HV229_RS00470	COG1442	glycosyl transferase family 8
HV229_RS00480	COG0859	PFAM glycosyl transferase family 9
HV229_RS00485	COG1216	Glycosyl transferase, family 2
HV229_RS00485	COG1442	glycosyl transferase family 8
HV229_RS00490	COG3307	-O-antigen
HV229_RS00500	COG0859	PFAM glycosyl transferase family 9
HV229_RS00510	COG0156	8-amino-7-oxononanoate synthase activity
HV229_RS00515	COG1063	alcohol dehydrogenase
HV229_RS00520	COG1216	Glycosyl transferase, family 2
HV229_RS00525	COG2861	carbohydrate metabolic process
HV229_RS00530	COG4942	peptidase
HV229_RS00540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV229_RS00545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV229_RS00565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV229_RS00570	COG2271	Major facilitator Superfamily
HV229_RS00580	COG2186	Transcriptional regulator
HV229_RS00610	COG3722	fumarate hydratase activity
HV229_RS00620	COG2213	PTS system mannitol-specific
HV229_RS00620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS00630	COG1566	PFAM secretion protein HlyD family protein
HV229_RS00635	COG0625	glutathione transferase activity
HV229_RS00645	COG3276	selenocysteine insertion sequence binding
HV229_RS00650	COG1454	alcohol dehydrogenase
HV229_RS00655	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS00665	COG1566	PFAM secretion protein HlyD family protein
HV229_RS00670	COG0583	DNA-binding transcription factor activity
HV229_RS00675	COG3713	MltA-interacting MipA family protein
HV229_RS00680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV229_RS00685	COG3977	Valine--pyruvate aminotransferase
HV229_RS00690	COG0366	Alpha amylase catalytic
HV229_RS00695	COG2992	FlgJ-related protein
HV229_RS00700	COG1609	Transcriptional regulator
HV229_RS00700	COG2207	Transcriptional regulator
HV229_RS00705	COG4214	carbohydrate transport
HV229_RS00715	COG4213	ABC transporter substrate-binding protein
HV229_RS00725	COG1070	Carbohydrate kinase
HV229_RS00730	COG4682	membrane
HV229_RS00735	COG4682	membrane
HV229_RS00740	COG3274	enterobacterial common antigen metabolic process
HV229_RS00765	COG1278	Cold shock
HV229_RS00770	COG2944	sequence-specific DNA binding
HV229_RS00785	COG2814	Major facilitator Superfamily
HV229_RS00790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS00800	COG1609	Transcriptional regulator
HV229_RS00805	COG2885	chlorophyll binding
HV229_RS00810	COG0243	molybdopterin cofactor binding
HV229_RS00815	COG0456	acetyltransferase
HV229_RS00820	COG2818	Glycosylase
HV229_RS00825	COG5571	outer membrane autotransporter
HV229_RS00830	COG2223	nitrite transmembrane transporter activity
HV229_RS00855	COG0747	negative chemotaxis
HV229_RS00860	COG0601	transmembrane transport
HV229_RS00865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV229_RS00870	COG0444	Belongs to the ABC transporter superfamily
HV229_RS00875	COG4608	Belongs to the ABC transporter superfamily
HV229_RS00880	COG2204	response regulator
HV229_RS00885	COG0814	amino acid
HV229_RS00900	COG2199	diguanylate cyclase activity
HV229_RS00900	COG2200	EAL domain
HV229_RS00915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS00920	COG2200	EAL domain
HV229_RS00925	COG2982	Protein involved in outer membrane biogenesis
HV229_RS00930	COG0477	Major facilitator Superfamily
HV229_RS00935	COG1295	ribonuclease BN
HV229_RS00940	COG0583	DNA-binding transcription factor activity
HV229_RS00950	COG2197	response regulator
HV229_RS00960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV229_RS00975	COG1858	cytochrome C peroxidase
HV229_RS00980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV229_RS00985	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV229_RS00990	COG0339	signal peptide processing
HV229_RS01005	COG1959	2 iron, 2 sulfur cluster binding
HV229_RS01015	COG0589	response to stress
HV229_RS01025	COG0306	phosphate transporter
HV229_RS01030	COG2081	HI0933 family
HV229_RS01035	COG2186	Transcriptional regulator
HV229_RS01040	COG0246	Mannitol dehydrogenase
HV229_RS01050	COG1063	alcohol dehydrogenase
HV229_RS01055	COG2271	Major facilitator Superfamily
HV229_RS01075	COG0277	FAD linked oxidase domain protein
HV229_RS01090	COG1454	alcohol dehydrogenase
HV229_RS01095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS01100	COG0842	Transport permease protein
HV229_RS01100	COG1129	ABC transporter
HV229_RS01105	COG0842	Transport permease protein
HV229_RS01120	COG3479	Phenolic acid decarboxylase
HV229_RS01125	COG2091	lysine biosynthetic process via aminoadipic acid
HV229_RS01130	COG0628	permease
HV229_RS01135	COG0477	Major facilitator Superfamily
HV229_RS01145	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV229_RS01160	COG3714	YhhN family
HV229_RS01170	COG3776	membrane
HV229_RS01175	COG0742	ribosomal rna small subunit methyltransferase
HV229_RS01180	COG0552	protein localization to endoplasmic reticulum
HV229_RS01185	COG2884	Cell division ATP-binding protein ftsE
HV229_RS01190	COG2177	Part of the ABC transporter FtsEX involved in
HV229_RS01200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV229_RS01205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV229_RS01230	COG0683	leucine binding
HV229_RS01240	COG0683	leucine binding
HV229_RS01250	COG4177	L-phenylalanine transmembrane transporter activity
HV229_RS01255	COG0411	ABC transporter
HV229_RS01260	COG0410	ABC transporter
HV229_RS01290	COG0584	glycerophosphoryl diester phosphodiesterase
HV229_RS01300	COG0405	Gamma-glutamyltransferase
HV229_RS01310	COG1247	-acetyltransferase
HV229_RS01315	COG0673	inositol 2-dehydrogenase activity
HV229_RS01320	COG1741	Belongs to the pirin family
HV229_RS01325	COG1609	Transcriptional regulator
HV229_RS01330	COG3265	gluconokinase activity
HV229_RS01335	COG2610	gluconate transmembrane transporter activity
HV229_RS01345	COG2095	MarC family integral membrane protein
HV229_RS01350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV229_RS01375	COG0058	SHG alpha-glucan phosphorylase activity
HV229_RS01380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV229_RS01395	COG1349	DNA-binding transcription factor activity
HV229_RS01405	COG0058	SHG alpha-glucan phosphorylase activity
HV229_RS01410	COG1640	4-alpha-glucanotransferase
HV229_RS01415	COG2610	gluconate transmembrane transporter activity
HV229_RS01425	COG1040	competence protein
HV229_RS01435	COG5464	transposase or invertase
HV229_RS01450	COG1918	ferrous iron import across plasma membrane
HV229_RS01455	COG2183	response to ionizing radiation
HV229_RS01460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV229_RS01465	COG0745	RESPONSE REGULATOR receiver
HV229_RS01480	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV229_RS01490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV229_RS01495	COG1011	Hydrolase
HV229_RS01505	COG0494	nUDIX hydrolase
HV229_RS01510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV229_RS01515	COG4972	Pilus assembly protein
HV229_RS01535	COG4796	Type ii and iii secretion system protein
HV229_RS01550	COG3266	domain, Protein
HV229_RS01555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV229_RS01560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV229_RS01570	COG0180	Tryptophanyl-tRNA synthetase
HV229_RS01590	COG2146	nitrite reductase [NAD(P)H] activity
HV229_RS01595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV229_RS01620	COG0512	Glutamine amidotransferase of anthranilate synthase
HV229_RS01625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV229_RS01630	COG1289	transmembrane transporter activity
HV229_RS01640	COG1765	OsmC-like protein
HV229_RS01645	COG3954	Phosphoribulokinase
HV229_RS01655	COG0429	hydrolase of the alpha beta-hydrolase fold
HV229_RS01660	COG0488	(ABC) transporter
HV229_RS01675	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV229_RS01680	COG1047	Peptidyl-prolyl cis-trans
HV229_RS01690	COG0545	Peptidyl-prolyl cis-trans isomerase
HV229_RS01695	COG2964	Protein conserved in bacteria
HV229_RS01755	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HV229_RS01760	COG3156	type II secretion system protein K
HV229_RS01765	COG4795	General secretion pathway protein
HV229_RS01770	COG2165	general secretion pathway protein
HV229_RS01775	COG2165	general secretion pathway protein
HV229_RS01780	COG2165	general secretion pathway protein
HV229_RS01785	COG1459	type II secretion system
HV229_RS01790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV229_RS01795	COG1450	Type ii and iii secretion system protein
HV229_RS01815	COG0051	transcription antitermination factor activity, RNA binding
HV229_RS01825	COG0088	Forms part of the polypeptide exit tunnel
HV229_RS01840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV229_RS01915	COG0200	Binds to the 23S rRNA
HV229_RS01920	COG0201	protein transport
HV229_RS01935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV229_RS01960	COG0789	Transcriptional regulator
HV229_RS01965	COG3036	rescue of stalled ribosome
HV229_RS01975	COG0569	domain protein
HV229_RS01995	COG0758	DNA mediated transformation
HV229_RS02005	COG0551	DNA topoisomerase type I activity
HV229_RS02025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV229_RS02105	COG1450	Type ii and iii secretion system protein
HV229_RS02150	COG1309	transcriptional regulator
HV229_RS02165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV229_RS02170	COG1027	Aspartate ammonia-lyase
HV229_RS02175	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV229_RS02180	COG0531	amino acid
HV229_RS02205	COG1509	lysine 2,3-aminomutase activity
HV229_RS02260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV229_RS02265	COG1053	succinate dehydrogenase
HV229_RS02280	COG3264	Mechanosensitive ion channel
HV229_RS02280	COG1511	domain protein
HV229_RS02315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV229_RS02320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV229_RS02320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV229_RS02325	COG0802	atpase or kinase
HV229_RS02330	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV229_RS02345	COG1923	regulation of RNA biosynthetic process
HV229_RS02350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV229_RS02355	COG0330	HflC and HflK could
HV229_RS02360	COG0330	HflC and HflK could
HV229_RS02365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV229_RS02380	COG0557	exoribonuclease II activity
HV229_RS02385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV229_RS02390	COG1960	acyl-CoA dehydrogenase activity
HV229_RS02400	COG3650	response to hydrogen peroxide
HV229_RS02405	COG1073	alpha beta
HV229_RS02455	COG0730	response to heat
HV229_RS02470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV229_RS02485	COG3061	Opacity-associated protein A
HV229_RS02490	COG0545	Peptidyl-prolyl cis-trans isomerase
HV229_RS02495	COG1113	amino acid transport
HV229_RS02505	COG0840	transmembrane signaling receptor activity
HV229_RS02510	COG0697	spore germination
HV229_RS02520	COG0702	epimerase
HV229_RS02525	COG1733	regulation of RNA biosynthetic process
HV229_RS02535	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV229_RS02540	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV229_RS02550	COG1253	flavin adenine dinucleotide binding
HV229_RS02560	COG0729	surface antigen
HV229_RS02565	COG2911	Protein conserved in bacteria
HV229_RS02570	COG2105	PFAM AIG2 family protein
HV229_RS02575	COG4771	TonB-dependent receptor
HV229_RS02580	COG3391	amine dehydrogenase activity
HV229_RS02590	COG1879	ABC-type sugar transport system periplasmic component
HV229_RS02595	COG1129	ABC transporter
HV229_RS02600	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS02605	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS02610	COG0840	transmembrane signaling receptor activity
HV229_RS02620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV229_RS02625	COG0517	IMP dehydrogenase activity
HV229_RS02625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV229_RS02630	COG1486	melibiose metabolic process
HV229_RS02640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV229_RS02650	COG0312	modulator of DNA gyrase
HV229_RS02685	COG3964	amidohydrolase
HV229_RS02700	COG3711	transcriptional antiterminator
HV229_RS02700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS02715	COG0366	Alpha amylase catalytic
HV229_RS02720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS02720	COG1263	PTS System
HV229_RS02735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV229_RS02780	COG1438	arginine binding
HV229_RS02785	COG1288	antiporter activity
HV229_RS02790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV229_RS02805	COG2731	YhcH YjgK YiaL family protein
HV229_RS02835	COG0525	valine-tRNA ligase activity
HV229_RS02840	COG2927	DNA polymerase III (CHI subunit)
HV229_RS02850	COG0795	lipopolysaccharide-transporting ATPase activity
HV229_RS02855	COG0795	lipopolysaccharide-transporting ATPase activity
HV229_RS02860	COG0433	COG0433 Predicted ATPase
HV229_RS02865	COG1609	Transcriptional regulator
HV229_RS02870	COG2610	gluconate transmembrane transporter activity
HV229_RS02875	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS02880	COG1063	alcohol dehydrogenase
HV229_RS02885	COG3265	gluconokinase activity
HV229_RS02890	COG1064	alcohol dehydrogenase
HV229_RS02900	COG0582	viral genome integration into host DNA
HV229_RS03045	COG0358	DNA primase activity
HV229_RS03050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV229_RS03055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV229_RS03060	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV229_RS03070	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV229_RS03100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS03105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS03120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV229_RS03135	COG4991	sh3 domain protein
HV229_RS03140	COG3025	triphosphatase activity
HV229_RS03195	COG3384	dioxygenase
HV229_RS03200	COG0754	glutathionylspermidine amidase activity
HV229_RS03215	COG0494	nUDIX hydrolase
HV229_RS03220	COG3151	Protein conserved in bacteria
HV229_RS03225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV229_RS03230	COG3150	esterase
HV229_RS03235	COG0187	DNA topoisomerase II activity
HV229_RS03240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV229_RS03245	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV229_RS03260	COG3111	PFAM Bacterial OB fold (BOF) protein
HV229_RS03280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV229_RS03295	COG0656	L-ascorbic acid biosynthetic process
HV229_RS03305	COG2207	Transcriptional regulator
HV229_RS03310	COG0586	Pfam SNARE associated Golgi protein
HV229_RS03315	COG0626	cystathionine gamma-synthase activity
HV229_RS03325	COG0848	biopolymer transport protein
HV229_RS03345	COG0667	Aldo Keto reductase
HV229_RS03355	COG0840	transmembrane signaling receptor activity
HV229_RS03365	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV229_RS03370	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS03375	COG5557	Pfam Polysulphide reductase, NrfD
HV229_RS03380	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV229_RS03385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV229_RS03390	COG1773	rubredoxin
HV229_RS03400	COG0298	carbon dioxide binding
HV229_RS03405	COG0625	glutathione transferase activity
HV229_RS03410	COG0243	molybdopterin cofactor binding
HV229_RS03415	COG0754	glutathionylspermidine amidase activity
HV229_RS03435	COG1846	Transcriptional regulator
HV229_RS03585	COG3039	Transposase
HV229_RS03600	COG3188	usher protein
HV229_RS03605	COG3121	Chaperone
HV229_RS03660	COG1216	Glycosyl transferase, family 2
HV229_RS03665	COG1442	glycosyl transferase family 8
HV229_RS03670	COG1216	Glycosyl transferase, family 2
HV229_RS03675	COG1216	Glycosyl transferase, family 2
HV229_RS03725	COG3344	reverse transcriptase
HV229_RS03735	COG2826	transposase and inactivated derivatives, IS30 family
HV229_RS03805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV229_RS03815	COG0629	single-stranded DNA binding
HV229_RS03970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV229_RS03975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV229_RS04015	COG1846	Transcriptional regulator
HV229_RS04040	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS04070	COG0739	heme binding
HV229_RS04080	COG2132	Multicopper oxidase
HV229_RS04085	COG3667	copper resistance
HV229_RS04090	COG2372	response to copper ion
HV229_RS04095	COG1276	copper resistance
HV229_RS04100	COG0745	RESPONSE REGULATOR receiver
HV229_RS04105	COG2205	protein histidine kinase activity
HV229_RS04115	COG1309	transcriptional regulator
HV229_RS04130	COG1136	(ABC) transporter
HV229_RS04140	COG1342	Belongs to the UPF0251 family
HV229_RS04165	COG3436	PFAM IS66 Orf2 family protein
HV229_RS04170	COG2433	Pfam Transposase IS66
HV229_RS04180	COG0640	Transcriptional regulator
HV229_RS04185	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV229_RS04195	COG3039	Transposase
HV229_RS04200	COG1528	Iron-storage protein
HV229_RS04270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HV229_RS04290	COG0210	DNA helicase
HV229_RS04300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV229_RS04310	COG1811	Na channel or pump
HV229_RS04315	COG1982	Orn Lys Arg decarboxylase major
HV229_RS04320	COG2211	Major facilitator Superfamily
HV229_RS04335	COG1194	a g-specific adenine glycosylase
HV229_RS04345	COG3171	Protein conserved in bacteria
HV229_RS04355	COG0252	asparaginase activity
HV229_RS04365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HV229_RS04365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HV229_RS04370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV229_RS04380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV229_RS04395	COG0762	integral membrane protein
HV229_RS04400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV229_RS04405	COG2805	Type II/IV secretion system protein
HV229_RS04420	COG0189	ligase activity
HV229_RS04425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV229_RS04430	COG2356	endonuclease I
HV229_RS04435	COG3091	SprT-like family
HV229_RS04440	COG2814	Major facilitator Superfamily
HV229_RS04460	COG1166	arginine decarboxylase activity
HV229_RS04475	COG0501	Belongs to the peptidase M48B family
HV229_RS04480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV229_RS04485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS04490	COG2213	PTS system mannitol-specific
HV229_RS04495	COG1063	alcohol dehydrogenase
HV229_RS04500	COG1494	fructose-1,6-bisphosphatase
HV229_RS04510	COG1072	(Pantothenic acid kinase))
HV229_RS04525	COG0191	fructose-bisphosphate aldolase activity
HV229_RS04530	COG0668	transmembrane transport
HV229_RS04540	COG1279	arginine transmembrane transporter activity
HV229_RS04545	COG2968	Membrane
HV229_RS04550	COG0583	DNA-binding transcription factor activity
HV229_RS04555	COG0427	acetyl-CoA hydrolase
HV229_RS04560	COG1024	Enoyl-CoA hydratase
HV229_RS04565	COG1703	isobutyryl-CoA mutase activity
HV229_RS04570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV229_RS04570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV229_RS04585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV229_RS04590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV229_RS04610	COG0006	proline dipeptidase activity
HV229_RS04615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV229_RS04620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV229_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS04645	COG2723	6-phospho-beta-galactosidase activity
HV229_RS04650	COG1737	Transcriptional regulator
HV229_RS04660	COG1272	protein, Hemolysin III
HV229_RS04670	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV229_RS04695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV229_RS04715	COG4942	peptidase
HV229_RS04730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV229_RS04735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV229_RS04740	COG0457	Tetratricopeptide repeat
HV229_RS04745	COG0438	transferase activity, transferring glycosyl groups
HV229_RS04750	COG1596	polysaccharide export
HV229_RS04755	COG1682	transport, permease protein
HV229_RS04760	COG1134	teichoic acid transport
HV229_RS04765	COG3524	carbohydrate:proton symporter activity
HV229_RS04770	COG4783	chaperone-mediated protein folding
HV229_RS04770	COG1560	Kdo2-lipid A biosynthetic process
HV229_RS04780	COG0457	Tetratricopeptide repeat
HV229_RS04785	COG0726	polysaccharide deacetylase
HV229_RS04785	COG1649	PFAM Uncharacterised BCR, COG1649
HV229_RS04790	COG1215	transferase activity, transferring glycosyl groups
HV229_RS04800	COG3592	Divergent 4Fe-4S mono-cluster
HV229_RS04805	COG2388	GCN5-related N-acetyl-transferase
HV229_RS04810	COG0583	DNA-binding transcription factor activity
HV229_RS04815	COG0666	response to abiotic stimulus
HV229_RS04825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV229_RS04830	COG1304	FMN binding
HV229_RS04840	COG0549	Belongs to the carbamate kinase family
HV229_RS04845	COG0402	S-adenosylhomocysteine deaminase activity
HV229_RS04860	COG0814	amino acid
HV229_RS04875	COG0183	Belongs to the thiolase family
HV229_RS04885	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS04895	COG1794	racemase activity, acting on amino acids and derivatives
HV229_RS04900	COG0583	DNA-binding transcription factor activity
HV229_RS04910	COG1609	Transcriptional regulator
HV229_RS04930	COG0667	Aldo Keto reductase
HV229_RS04940	COG0861	Integral membrane protein TerC family
HV229_RS04970	COG2165	general secretion pathway protein
HV229_RS04975	COG4795	General secretion pathway protein
HV229_RS04985	COG4967	type IV pilus modification protein PilV
HV229_RS04990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV229_RS05000	COG1074	ATP-dependent DNA helicase activity
HV229_RS05005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV229_RS05010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV229_RS05010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV229_RS05015	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV229_RS05035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV229_RS05040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV229_RS05045	COG2166	iron-sulfur cluster assembly
HV229_RS05050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV229_RS05060	COG0583	DNA-binding transcription factor activity
HV229_RS05065	COG2363	Small membrane protein
HV229_RS05075	COG1349	DNA-binding transcription factor activity
HV229_RS05095	COG1129	ABC transporter
HV229_RS05100	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS05110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV229_RS05120	COG0235	Class ii aldolase
HV229_RS05125	COG1454	alcohol dehydrogenase
HV229_RS05135	COG1760	l-serine dehydratase
HV229_RS05140	COG0814	amino acid
HV229_RS05145	COG1611	Belongs to the LOG family
HV229_RS05160	COG3098	single-species biofilm formation
HV229_RS05165	COG0564	pseudouridine synthase activity
HV229_RS05170	COG0716	FMN binding
HV229_RS05175	COG2271	Major facilitator Superfamily
HV229_RS05180	COG4948	Mandelate Racemase Muconate Lactonizing
HV229_RS05185	COG4948	Mandelate Racemase Muconate Lactonizing
HV229_RS05190	COG1929	Belongs to the glycerate kinase type-1 family
HV229_RS05195	COG3437	response regulator, receiver
HV229_RS05195	COG3850	Histidine kinase
HV229_RS05195	COG4999	Histidine kinase
HV229_RS05195	COG2205	protein histidine kinase activity
HV229_RS05205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV229_RS05210	COG3956	TIGRFAM MazG family protein
HV229_RS05260	COG3121	Chaperone
HV229_RS05280	COG0602	queuosine metabolic process
HV229_RS05285	COG1070	Carbohydrate kinase
HV229_RS05290	COG0720	synthase
HV229_RS05310	COG1203	CRISPR-associated helicase, Cas3
HV229_RS05325	COG1857	crispr-associated protein
HV229_RS05340	COG1518	maintenance of DNA repeat elements
HV229_RS05345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV229_RS05350	COG2433	Pfam Transposase IS66
HV229_RS05355	COG3436	PFAM IS66 Orf2 family protein
HV229_RS05365	COG2234	aminopeptidase activity
HV229_RS05420	COG4942	peptidase
HV229_RS05420	COG1388	LysM domain
HV229_RS05435	COG0582	viral genome integration into host DNA
HV229_RS05495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV229_RS05505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV229_RS05520	COG1196	nuclear chromosome segregation
HV229_RS05545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HV229_RS05555	COG3188	usher protein
HV229_RS05585	COG2200	EAL domain
HV229_RS05590	COG3710	Transcriptional regulator
HV229_RS05615	COG2200	EAL domain
HV229_RS05620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV229_RS05625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV229_RS05630	COG1121	(ABC) transporter
HV229_RS05650	COG0309	Hydrogenase expression formation protein (HypE)
HV229_RS05655	COG0409	Hydrogenase expression formation protein
HV229_RS05660	COG0298	carbon dioxide binding
HV229_RS05665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV229_RS05680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV229_RS05685	COG0651	ATP synthesis coupled electron transport
HV229_RS05690	COG0650	Formate hydrogenlyase subunit 4
HV229_RS05695	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV229_RS05695	COG3261	NADH dehydrogenase
HV229_RS05700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV229_RS05705	COG3260	NADH ubiquinone oxidoreductase 20
HV229_RS05715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV229_RS05730	COG2723	6-phospho-beta-galactosidase activity
HV229_RS05735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS05735	COG1263	PTS System
HV229_RS05740	COG1609	Transcriptional regulator
HV229_RS05745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV229_RS05750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV229_RS05770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV229_RS05770	COG0517	IMP dehydrogenase activity
HV229_RS05775	COG1349	DNA-binding transcription factor activity
HV229_RS05780	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS05795	COG3732	PTS system glucitol sorbitol-specific
HV229_RS05800	COG3730	PTS system glucitol sorbitol-specific
HV229_RS05805	COG2951	lytic endotransglycosylase activity
HV229_RS05810	COG1546	Belongs to the CinA family
HV229_RS05830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV229_RS05860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV229_RS05865	COG1238	metal cluster binding
HV229_RS05880	COG2814	Major facilitator Superfamily
HV229_RS05885	COG1566	PFAM secretion protein HlyD family protein
HV229_RS05890	COG1846	Transcriptional regulator
HV229_RS05900	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV229_RS05905	COG2814	Major facilitator Superfamily
HV229_RS05915	COG4176	ABC-type proline glycine betaine transport system permease component
HV229_RS05945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV229_RS05975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV229_RS05980	COG0640	Transcriptional regulator
HV229_RS05985	COG0401	homolog of Blt101
HV229_RS05990	COG1652	LysM domain
HV229_RS05995	COG1802	Transcriptional regulator
HV229_RS06000	COG1113	amino acid transport
HV229_RS06005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV229_RS06010	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS06015	COG0579	oxidoreductase
HV229_RS06055	COG0642	Histidine kinase
HV229_RS06065	COG3188	usher protein
HV229_RS06070	COG3121	Chaperone
HV229_RS06115	COG0438	transferase activity, transferring glycosyl groups
HV229_RS06120	COG0297	glycogen (starch) synthase activity
HV229_RS06120	COG0438	transferase activity, transferring glycosyl groups
HV229_RS06150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV229_RS06155	COG1757	Na H antiporter
HV229_RS06160	COG2169	Transcriptional regulator
HV229_RS06170	COG3039	Transposase
HV229_RS06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS06205	COG2867	negative regulation of translational initiation
HV229_RS06220	COG0497	DNA recombination
HV229_RS06235	COG4536	flavin adenine dinucleotide binding
HV229_RS06240	COG4137	Cytochrome C assembly protein
HV229_RS06245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV229_RS06270	COG2885	chlorophyll binding
HV229_RS06275	COG2199	diguanylate cyclase activity
HV229_RS06290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV229_RS06295	COG0287	Prephenate dehydrogenase
HV229_RS06295	COG1605	Chorismate mutase
HV229_RS06300	COG1605	Chorismate mutase
HV229_RS06300	COG0077	Prephenate dehydratase
HV229_RS06310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV229_RS06315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV229_RS06330	COG0542	response to heat
HV229_RS06355	COG0477	Major facilitator Superfamily
HV229_RS06360	COG5544	Lipoprotein
HV229_RS06365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV229_RS06380	COG3118	belongs to the thioredoxin family
HV229_RS06385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV229_RS06400	COG0513	Belongs to the DEAD box helicase family
HV229_RS06410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV229_RS06420	COG1595	DNA-templated transcription, initiation
HV229_RS06430	COG3026	antisigma factor binding
HV229_RS06435	COG3086	response to oxidative stress
HV229_RS06445	COG0681	Belongs to the peptidase S26 family
HV229_RS06465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV229_RS06475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV229_RS06480	COG1737	Transcriptional regulator
HV229_RS06485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV229_RS06490	COG1263	PTS System
HV229_RS06490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS06495	COG0560	Phosphoserine phosphatase
HV229_RS06515	COG2205	protein histidine kinase activity
HV229_RS06520	COG3170	Tfp pilus assembly protein FimV
HV229_RS06525	COG2204	response regulator
HV229_RS06530	COG0347	Belongs to the P(II) protein family
HV229_RS06535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV229_RS06535	COG1017	nitric oxide dioxygenase activity
HV229_RS06565	COG4638	Rieske (2fe-2S)
HV229_RS06570	COG0583	DNA-binding transcription factor activity
HV229_RS06575	COG1940	carbohydrate kinase activity
HV229_RS06580	COG0457	Tetratricopeptide repeat
HV229_RS06585	COG0477	Major facilitator Superfamily
HV229_RS06585	COG2814	Major facilitator Superfamily
HV229_RS06595	COG2814	Major facilitator Superfamily
HV229_RS06600	COG3711	transcriptional antiterminator
HV229_RS06605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV229_RS06605	COG0517	IMP dehydrogenase activity
HV229_RS06610	COG1069	ribulokinase activity
HV229_RS06620	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS06625	COG1129	ABC transporter
HV229_RS06635	COG3683	transport system, periplasmic component
HV229_RS06640	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV229_RS06665	COG0822	iron-sulfur transferase activity
HV229_RS06685	COG0633	Ferredoxin
HV229_RS06690	COG2975	iron-sulfur cluster assembly
HV229_RS06705	COG2897	thiosulfate sulfurtransferase activity
HV229_RS06710	COG2373	Large extracellular alpha-helical protein
HV229_RS06715	COG4953	penicillin-binding protein 1C
HV229_RS06745	COG2976	Protein conserved in bacteria
HV229_RS06760	COG3104	oligopeptide transport
HV229_RS06770	COG1645	bacterial-type flagellum-dependent swarming motility
HV229_RS06775	COG1570	exodeoxyribonuclease VII activity
HV229_RS06780	COG0516	GMP reductase activity
HV229_RS06780	COG0517	IMP dehydrogenase activity
HV229_RS06795	COG2200	EAL domain
HV229_RS06810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV229_RS06820	COG2723	6-phospho-beta-galactosidase activity
HV229_RS06830	COG2233	PERMEase
HV229_RS06840	COG1393	Belongs to the ArsC family
HV229_RS06845	COG4783	chaperone-mediated protein folding
HV229_RS06850	COG0628	permease
HV229_RS06855	COG3366	ferrous iron transmembrane transporter activity
HV229_RS06860	COG0700	Nucleoside recognition
HV229_RS06865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV229_RS06870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV229_RS06875	COG2716	regulation of RNA biosynthetic process
HV229_RS06885	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV229_RS06895	COG2321	neutral zinc metallopeptidase
HV229_RS06905	COG0400	carboxylic ester hydrolase activity
HV229_RS06920	COG1393	Belongs to the ArsC family
HV229_RS06935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV229_RS06940	COG3850	Histidine kinase
HV229_RS06945	COG0493	'glutamate synthase
HV229_RS06945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV229_RS06955	COG5342	invasion associated locus B
HV229_RS06960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV229_RS06980	COG4766	ethanolamine catabolic process
HV229_RS06985	COG4812	Cobalamin adenosyltransferase
HV229_RS07050	COG2207	Transcriptional regulator
HV229_RS07060	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV229_RS07080	COG2837	iron assimilation
HV229_RS07085	COG0165	Argininosuccinate lyase
HV229_RS07090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV229_RS07095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV229_RS07100	COG2186	Transcriptional regulator
HV229_RS07110	COG4150	thiosulfate binding
HV229_RS07115	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV229_RS07120	COG4208	sulfate ABC transporter
HV229_RS07125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV229_RS07190	COG3530	Putative quorum-sensing-regulated virulence factor
HV229_RS07195	COG0385	Bile acid
HV229_RS07200	COG0583	DNA-binding transcription factor activity
HV229_RS07210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV229_RS07215	COG2211	Major facilitator Superfamily
HV229_RS07225	COG0583	DNA-binding transcription factor activity
HV229_RS07255	COG3415	Transposase
HV229_RS07260	COG3415	Transposase
HV229_RS07275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV229_RS07290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV229_RS07295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV229_RS07300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS07300	COG1263	PTS System
HV229_RS07310	COG0667	Aldo Keto reductase
HV229_RS07315	COG3961	Belongs to the TPP enzyme family
HV229_RS07330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS07335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS07340	COG0006	proline dipeptidase activity
HV229_RS07345	COG1363	Peptidase, m42
HV229_RS07360	COG2207	Transcriptional regulator
HV229_RS07365	COG3279	Response regulator of the LytR AlgR family
HV229_RS07370	COG3275	phosphorelay sensor kinase activity
HV229_RS07375	COG0436	Aminotransferase
HV229_RS07390	COG1560	Kdo2-lipid A biosynthetic process
HV229_RS07420	COG3122	Protein conserved in bacteria
HV229_RS07425	COG0840	transmembrane signaling receptor activity
HV229_RS07430	COG1446	asparaginase
HV229_RS07455	COG2003	Belongs to the UPF0758 family
HV229_RS07485	COG2378	regulation of single-species biofilm formation
HV229_RS07490	COG3596	GTP binding
HV229_RS07535	COG2826	transposase and inactivated derivatives, IS30 family
HV229_RS07545	COG3344	reverse transcriptase
HV229_RS07580	COG2223	nitrite transmembrane transporter activity
HV229_RS07590	COG1609	Transcriptional regulator
HV229_RS07615	COG2003	Belongs to the UPF0758 family
HV229_RS07625	COG3468	outer membrane autotransporter barrel domain protein
HV229_RS07630	COG2378	regulation of single-species biofilm formation
HV229_RS07640	COG3596	GTP binding
HV229_RS07675	COG2020	methyltransferase activity
HV229_RS07685	COG2020	methyltransferase activity
HV229_RS07695	COG2433	Pfam Transposase IS66
HV229_RS07700	COG3436	PFAM IS66 Orf2 family protein
HV229_RS07765	COG0582	viral genome integration into host DNA
HV229_RS07780	COG2116	formate transmembrane transporter activity
HV229_RS07790	COG2067	long-chain fatty acid transport protein
HV229_RS07795	COG3691	Protein conserved in bacteria
HV229_RS07810	COG2062	phosphohistidine phosphatase, SixA
HV229_RS07840	COG0730	response to heat
HV229_RS07845	COG3101	peptidyl-lysine hydroxylation
HV229_RS07860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV229_RS07890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV229_RS07900	COG0586	Pfam SNARE associated Golgi protein
HV229_RS07910	COG0285	dihydrofolate synthase activity
HV229_RS07915	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV229_RS07920	COG1286	toxin biosynthetic process
HV229_RS07925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV229_RS07930	COG0163	prenyltransferase activity
HV229_RS07940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV229_RS07955	COG4598	ABC transporter
HV229_RS07960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV229_RS07965	COG1090	epimerase
HV229_RS07970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV229_RS07975	COG0625	glutathione transferase activity
HV229_RS07980	COG0625	glutathione transferase activity
HV229_RS07985	COG0622	Phosphoesterase
HV229_RS07995	COG1288	antiporter activity
HV229_RS08020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV229_RS08025	COG0471	metal ion transport
HV229_RS08025	COG0490	domain, Protein
HV229_RS08035	COG0436	Aminotransferase
HV229_RS08040	COG0583	DNA-binding transcription factor activity
HV229_RS08060	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV229_RS08085	COG0839	Belongs to the complex I subunit 6 family
HV229_RS08095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV229_RS08100	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV229_RS08110	COG0835	chemotaxis
HV229_RS08110	COG0784	Response regulator, receiver
HV229_RS08120	COG2153	protein acetylation
HV229_RS08125	COG4575	ribosome binding
HV229_RS08130	COG1169	isochorismate synthase
HV229_RS08215	COG1414	Transcriptional regulator
HV229_RS08225	COG2271	Major facilitator Superfamily
HV229_RS08235	COG5464	transposase or invertase
HV229_RS08240	COG0247	lactate metabolic process
HV229_RS08250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV229_RS08255	COG2271	Major facilitator Superfamily
HV229_RS08260	COG0584	glycerophosphoryl diester phosphodiesterase
HV229_RS08265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV229_RS08290	COG0183	Belongs to the thiolase family
HV229_RS08295	COG2031	fatty acid transporter
HV229_RS08300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV229_RS08305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV229_RS08310	COG2204	response regulator
HV229_RS08315	COG3852	Histidine kinase
HV229_RS08330	COG0642	Histidine kinase
HV229_RS08330	COG2198	Histidine kinase
HV229_RS08335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV229_RS08340	COG1477	protein flavinylation
HV229_RS08345	COG2169	Transcriptional regulator
HV229_RS08345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV229_RS08350	COG3145	DNA-N1-methyladenine dioxygenase activity
HV229_RS08355	COG4615	Cyclic peptide transporter
HV229_RS08360	COG2239	Acts as a magnesium transporter
HV229_RS08365	COG0659	secondary active sulfate transmembrane transporter activity
HV229_RS08380	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV229_RS08380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV229_RS08385	COG3062	negative regulation of establishment of protein localization
HV229_RS08395	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS08400	COG0348	domain, Protein
HV229_RS08405	COG3043	anaerobic respiration
HV229_RS08410	COG3005	denitrification pathway
HV229_RS08415	COG4133	protoheme IX ABC transporter activity
HV229_RS08425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV229_RS08430	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV229_RS08440	COG1138	Cytochrome C-type biogenesis protein
HV229_RS08445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV229_RS08450	COG3088	subunit of a heme lyase
HV229_RS08450	COG4235	cytochrome complex assembly
HV229_RS08455	COG2197	response regulator
HV229_RS08465	COG2826	transposase and inactivated derivatives, IS30 family
HV229_RS08505	COG1061	Type III restriction enzyme res subunit
HV229_RS08510	COG1187	pseudouridine synthase activity
HV229_RS08515	COG2814	Major facilitator Superfamily
HV229_RS08525	COG4172	Belongs to the ABC transporter superfamily
HV229_RS08530	COG4239	(ABC) transporter, permease
HV229_RS08535	COG4174	ABC transporter (Permease)
HV229_RS08540	COG4166	transmembrane transport
HV229_RS08545	COG2200	EAL domain
HV229_RS08550	COG0791	NLP P60 protein
HV229_RS08555	COG0671	phosphoesterase, PA-phosphatase related
HV229_RS08560	COG0523	cobalamin synthesis protein
HV229_RS08565	COG0246	Mannitol dehydrogenase
HV229_RS08570	COG1312	Catalyzes the dehydration of D-mannonate
HV229_RS08575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV229_RS08580	COG3005	denitrification pathway
HV229_RS08590	COG3381	protein complex oligomerization
HV229_RS08655	COG1105	Belongs to the carbohydrate kinase PfkB family
HV229_RS08660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS08660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS08660	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV229_RS08665	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV229_RS08675	COG0583	DNA-binding transcription factor activity
HV229_RS08680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS08685	COG2313	pseudouridylate synthase activity
HV229_RS08690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV229_RS08695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS08695	COG1522	sequence-specific DNA binding
HV229_RS08705	COG2855	membrane
HV229_RS08710	COG0583	DNA-binding transcription factor activity
HV229_RS08715	COG0833	amino acid
HV229_RS08720	COG4771	TonB-dependent receptor
HV229_RS08735	COG2311	Membrane
HV229_RS08750	COG1129	ABC transporter
HV229_RS08765	COG0493	'glutamate synthase
HV229_RS08775	COG2949	membrane
HV229_RS08785	COG1346	cytolysis
HV229_RS08800	COG2271	Major facilitator Superfamily
HV229_RS08815	COG0625	glutathione transferase activity
HV229_RS08820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV229_RS08825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV229_RS08840	COG0586	Pfam SNARE associated Golgi protein
HV229_RS08850	COG1686	Belongs to the peptidase S11 family
HV229_RS08855	COG0277	FAD linked oxidase domain protein
HV229_RS08860	COG1472	Belongs to the glycosyl hydrolase 3 family
HV229_RS08865	COG1732	Glycine betaine
HV229_RS08870	COG1174	glycine betaine transport
HV229_RS08875	COG1125	glycine betaine transport
HV229_RS08880	COG1174	glycine betaine transport
HV229_RS08890	COG0789	Transcriptional regulator
HV229_RS08895	COG3275	phosphorelay sensor kinase activity
HV229_RS08905	COG4807	Protein conserved in bacteria
HV229_RS08910	COG4808	Protein conserved in bacteria
HV229_RS08935	COG3121	Chaperone
HV229_RS08950	COG5455	response to cobalt ion
HV229_RS08960	COG0351	phosphomethylpyrimidine kinase
HV229_RS08965	COG2188	Transcriptional regulator
HV229_RS08970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS08975	COG1397	ADP-ribosylglycohydrolase
HV229_RS08980	COG2211	Major facilitator Superfamily
HV229_RS08985	COG1830	Aldolase
HV229_RS08995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV229_RS09000	COG4160	amino acid transport
HV229_RS09005	COG4215	(ABC) transporter
HV229_RS09010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV229_RS09015	COG1126	abc transporter atp-binding protein
HV229_RS09030	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV229_RS09035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV229_RS09040	COG0702	epimerase
HV229_RS09045	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV229_RS09050	COG0028	Belongs to the TPP enzyme family
HV229_RS09060	COG4529	Protein conserved in bacteria
HV229_RS09065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV229_RS09075	COG2431	L-lysine efflux transmembrane transporter activity
HV229_RS09085	COG3593	DNA synthesis involved in DNA repair
HV229_RS09090	COG2990	Protein conserved in bacteria
HV229_RS09095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS09105	COG1278	Cold shock
HV229_RS09115	COG0542	response to heat
HV229_RS09120	COG4974	Belongs to the 'phage' integrase family
HV229_RS09165	COG4695	Portal protein
HV229_RS09260	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV229_RS09320	COG0745	RESPONSE REGULATOR receiver
HV229_RS09325	COG2205	protein histidine kinase activity
HV229_RS09355	COG0443	Heat shock 70 kDa protein
HV229_RS09360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV229_RS09365	COG5002	protein histidine kinase activity
HV229_RS09365	COG3447	MASE1 domain protein
HV229_RS09365	COG5001	Diguanylate cyclase
HV229_RS09380	COG2982	Protein involved in outer membrane biogenesis
HV229_RS09385	COG1253	flavin adenine dinucleotide binding
HV229_RS09405	COG0463	Glycosyl transferase, family 2
HV229_RS09410	COG1045	serine acetyltransferase
HV229_RS09415	COG0438	transferase activity, transferring glycosyl groups
HV229_RS09425	COG1216	Glycosyl transferase, family 2
HV229_RS09430	COG0110	maltose O-acetyltransferase activity
HV229_RS09435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV229_RS09440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV229_RS09445	COG1051	belongs to the nudix hydrolase family
HV229_RS09450	COG0297	glycogen (starch) synthase activity
HV229_RS09460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV229_RS09465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV229_RS09470	COG2244	polysaccharide biosynthetic process
HV229_RS09475	COG2327	Polysaccharide pyruvyl transferase
HV229_RS09490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV229_RS09510	COG0438	transferase activity, transferring glycosyl groups
HV229_RS09515	COG2244	polysaccharide biosynthetic process
HV229_RS09530	COG3039	Transposase
HV229_RS09535	COG0438	transferase activity, transferring glycosyl groups
HV229_RS09550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV229_RS09565	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV229_RS09585	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV229_RS09615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV229_RS09620	COG0583	DNA-binding transcription factor activity
HV229_RS09630	COG0531	amino acid
HV229_RS09635	COG2925	Exonuclease
HV229_RS09665	COG1289	transmembrane transporter activity
HV229_RS09700	COG4656	Part of a membrane complex involved in electron transport
HV229_RS09710	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS09890	COG1376	ErfK ybiS ycfS ynhG family protein
HV229_RS09900	COG1178	ABC-type Fe3 transport system permease component
HV229_RS09905	COG1840	ABC-type Fe3 transport system, periplasmic component
HV229_RS09925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV229_RS09930	COG1418	mRNA catabolic process
HV229_RS09935	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV229_RS09940	COG3727	T/G mismatch-specific endonuclease activity
HV229_RS09945	COG0697	spore germination
HV229_RS09950	COG2354	Protein conserved in bacteria
HV229_RS09955	COG5475	Uncharacterized small protein (DUF2158)
HV229_RS10015	COG2882	bacterial-type flagellum organization
HV229_RS10045	COG0425	Belongs to the sulfur carrier protein TusA family
HV229_RS10060	COG0366	Alpha amylase catalytic
HV229_RS10115	COG2197	response regulator
HV229_RS10125	COG2197	response regulator
HV229_RS10175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV229_RS10200	COG1278	Cold shock
HV229_RS10215	COG0431	NADPH-dependent FMN reductase
HV229_RS10220	COG0640	Transcriptional regulator
HV229_RS10245	COG1305	Transglutaminase-like
HV229_RS10255	COG2608	mercury ion transmembrane transporter activity
HV229_RS10260	COG3012	SEC-C Motif Domain Protein
HV229_RS10260	COG3318	Belongs to the UPF0149 family
HV229_RS10265	COG0814	amino acid
HV229_RS10275	COG1528	Iron-storage protein
HV229_RS10290	COG0477	Major facilitator Superfamily
HV229_RS10300	COG1528	Iron-storage protein
HV229_RS10310	COG1879	ABC-type sugar transport system periplasmic component
HV229_RS10315	COG1129	ABC transporter
HV229_RS10320	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS10365	COG0835	chemotaxis
HV229_RS10370	COG1301	dicarboxylic acid transport
HV229_RS10380	COG0840	transmembrane signaling receptor activity
HV229_RS10395	COG0745	RESPONSE REGULATOR receiver
HV229_RS10405	COG4977	sequence-specific DNA binding
HV229_RS10410	COG2814	Major facilitator Superfamily
HV229_RS10415	COG3250	beta-galactosidase activity
HV229_RS10440	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV229_RS10455	COG3102	Protein conserved in bacteria
HV229_RS10475	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV229_RS10480	COG1801	Protein of unknown function DUF72
HV229_RS10535	COG3039	Transposase
HV229_RS10550	COG3039	Transposase
HV229_RS10560	COG2433	Pfam Transposase IS66
HV229_RS10565	COG3436	PFAM IS66 Orf2 family protein
HV229_RS10585	COG1335	isochorismatase
HV229_RS10595	COG0494	nUDIX hydrolase
HV229_RS10615	COG2255	four-way junction helicase activity
HV229_RS10620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV229_RS10640	COG1187	pseudouridine synthase activity
HV229_RS10670	COG0538	isocitrate dehydrogenase activity
HV229_RS10675	COG2814	Major facilitator Superfamily
HV229_RS10680	COG1414	Transcriptional regulator
HV229_RS10710	COG0768	penicillin binding
HV229_RS10715	COG2226	methyltransferase
HV229_RS10730	COG3716	PTS system mannose fructose sorbose family IID component
HV229_RS10735	COG3715	PTS system
HV229_RS10740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS10740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS10745	COG1253	flavin adenine dinucleotide binding
HV229_RS10750	COG2200	EAL domain
HV229_RS10755	COG1760	l-serine dehydratase
HV229_RS10775	COG0251	oxidation-reduction process
HV229_RS10780	COG1199	ATP-dependent helicase activity
HV229_RS10785	COG1214	PFAM Peptidase M22, glycoprotease
HV229_RS10790	COG3065	identical protein binding
HV229_RS10795	COG0318	PFAM AMP-dependent synthetase and ligase
HV229_RS10800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV229_RS10805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV229_RS10810	COG4638	Rieske (2fe-2S)
HV229_RS10815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV229_RS10820	COG0473	3-isopropylmalate dehydrogenase activity
HV229_RS10825	COG0583	DNA-binding transcription factor activity
HV229_RS10835	COG2894	cell division
HV229_RS10850	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV229_RS10880	COG2719	SpoVR family
HV229_RS10890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV229_RS10900	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV229_RS10925	COG0157	Belongs to the NadC ModD family
HV229_RS10930	COG0500	methyltransferase
HV229_RS10935	COG1120	ATPase activity
HV229_RS10960	COG1461	Dihydroxyacetone kinase
HV229_RS10965	COG2376	Dihydroxyacetone kinase
HV229_RS10970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV229_RS10995	COG0789	Transcriptional regulator
HV229_RS11000	COG2200	EAL domain
HV229_RS11030	COG0702	epimerase
HV229_RS11040	COG0667	Aldo Keto reductase
HV229_RS11045	COG0656	L-ascorbic acid biosynthetic process
HV229_RS11065	COG0300	oxidoreductase activity
HV229_RS11080	COG2433	Pfam Transposase IS66
HV229_RS11085	COG3436	PFAM IS66 Orf2 family protein
HV229_RS11115	COG2801	Transposase and inactivated derivatives
HV229_RS11135	COG0582	viral genome integration into host DNA
HV229_RS11140	COG0012	GTP binding
HV229_RS11155	COG0527	aspartate kinase activity
HV229_RS11160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV229_RS11165	COG0076	glutamate decarboxylase activity
HV229_RS11170	COG0659	secondary active sulfate transmembrane transporter activity
HV229_RS11200	COG2890	protein-(glutamine-N5) methyltransferase activity
HV229_RS11205	COG3094	Invasion gene expression up-regulator, SirB
HV229_RS11220	COG0387	Pfam Sodium calcium exchanger
HV229_RS11225	COG4572	Cation transport regulator
HV229_RS11230	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV229_RS11240	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV229_RS11245	COG4932	domain protein
HV229_RS11250	COG2197	response regulator
HV229_RS11255	COG3850	Histidine kinase
HV229_RS11260	COG2223	nitrite transmembrane transporter activity
HV229_RS11265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV229_RS11270	COG1140	nitrate reductase beta subunit
HV229_RS11275	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV229_RS11280	COG2181	nitrate reductase activity
HV229_RS11305	COG0788	formyltetrahydrofolate deformylase activity
HV229_RS11315	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV229_RS11320	COG0745	RESPONSE REGULATOR receiver
HV229_RS11325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV229_RS11335	COG1435	thymidine kinase activity
HV229_RS11340	COG1454	alcohol dehydrogenase
HV229_RS11340	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS11345	COG2095	MarC family integral membrane protein
HV229_RS11365	COG0444	Belongs to the ABC transporter superfamily
HV229_RS11375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV229_RS11395	COG2350	Protein conserved in bacteria
HV229_RS11420	COG3047	cAMP biosynthetic process
HV229_RS11430	COG3706	GGDEF domain
HV229_RS11470	COG0009	L-threonylcarbamoyladenylate synthase
HV229_RS11475	COG1187	pseudouridine synthase activity
HV229_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS11490	COG0616	signal peptide processing
HV229_RS11505	COG0583	DNA-binding transcription factor activity
HV229_RS11520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV229_RS11530	COG0671	phosphoesterase, PA-phosphatase related
HV229_RS11535	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV229_RS11540	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV229_RS11550	COG0023	Translation Initiation Factor
HV229_RS11560	COG1349	DNA-binding transcription factor activity
HV229_RS11570	COG5001	Diguanylate cyclase
HV229_RS11580	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV229_RS11580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV229_RS11585	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV229_RS11600	COG4172	Belongs to the ABC transporter superfamily
HV229_RS11605	COG4171	peptide transport system, permease
HV229_RS11630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV229_RS11635	COG1842	Phage shock protein A
HV229_RS11645	COG1983	PspC domain protein
HV229_RS11655	COG0366	Alpha amylase catalytic
HV229_RS11660	COG1653	transport
HV229_RS11665	COG1175	transmembrane transport
HV229_RS11670	COG0395	ABC-type sugar transport system, permease component
HV229_RS11675	COG1063	alcohol dehydrogenase
HV229_RS11680	COG1082	Xylose isomerase domain protein TIM barrel
HV229_RS11685	COG0673	inositol 2-dehydrogenase activity
HV229_RS11690	COG1554	hydrolase, family 65, central catalytic
HV229_RS11695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV229_RS11710	COG1609	Transcriptional regulator
HV229_RS11715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV229_RS11720	COG3106	COG3106 Predicted ATPase
HV229_RS11735	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV229_RS11740	COG4948	Mandelate Racemase Muconate Lactonizing
HV229_RS11745	COG2866	Carboxypeptidase
HV229_RS11750	COG4166	transmembrane transport
HV229_RS11755	COG1349	DNA-binding transcription factor activity
HV229_RS11760	COG0346	lactoylglutathione lyase activity
HV229_RS11775	COG0668	transmembrane transport
HV229_RS11780	COG3182	Iron-regulated membrane protein
HV229_RS11805	COG2840	Smr protein MutS2
HV229_RS11810	COG3706	GGDEF domain
HV229_RS11820	COG0840	transmembrane signaling receptor activity
HV229_RS11835	COG0513	Belongs to the DEAD box helicase family
HV229_RS11860	COG1045	serine acetyltransferase
HV229_RS11875	COG0589	response to stress
HV229_RS11885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV229_RS11890	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV229_RS11890	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV229_RS11890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV229_RS11890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV229_RS11895	COG3042	response to heat
HV229_RS11900	COG3187	Heat shock protein
HV229_RS11905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV229_RS11910	COG2911	Protein conserved in bacteria
HV229_RS11920	COG3784	Protein of unknown function (DUF1318)
HV229_RS11935	COG1643	Atp-dependent helicase
HV229_RS11940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV229_RS11945	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS11950	COG3038	cytochrome b561
HV229_RS11955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV229_RS11960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV229_RS11980	COG0840	transmembrane signaling receptor activity
HV229_RS11985	COG0583	DNA-binding transcription factor activity
HV229_RS11990	COG1227	inorganic diphosphatase activity
HV229_RS11995	COG5383	Protein conserved in bacteria
HV229_RS12005	COG2841	Protein conserved in bacteria
HV229_RS12010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV229_RS12015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV229_RS12020	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV229_RS12025	COG0500	methyltransferase
HV229_RS12035	COG0697	spore germination
HV229_RS12045	COG3135	benzoate transporter
HV229_RS12050	COG1396	sequence-specific DNA binding
HV229_RS12055	COG0826	peptidase U32
HV229_RS12070	COG1294	oxidase, subunit
HV229_RS12075	COG1271	oxidase subunit
HV229_RS12080	COG1724	mRNA binding
HV229_RS12085	COG1598	PFAM Uncharacterised protein family UPF0150
HV229_RS12090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV229_RS12095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV229_RS12100	COG3842	ATPase activity
HV229_RS12105	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV229_RS12110	COG1177	transmembrane transport
HV229_RS12120	COG2814	Major facilitator Superfamily
HV229_RS12155	COG0747	negative chemotaxis
HV229_RS12165	COG3238	Protein conserved in bacteria
HV229_RS12170	COG1247	-acetyltransferase
HV229_RS12180	COG2130	NADP-dependent
HV229_RS12185	COG4772	TonB-dependent receptor
HV229_RS12205	COG0840	transmembrane signaling receptor activity
HV229_RS12210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV229_RS12215	COG1473	amidohydrolase
HV229_RS12220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV229_RS12225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV229_RS12240	COG1126	abc transporter atp-binding protein
HV229_RS12245	COG0625	glutathione transferase activity
HV229_RS12250	COG2271	Major facilitator Superfamily
HV229_RS12260	COG1609	Transcriptional regulator
HV229_RS12270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV229_RS12275	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV229_RS12280	COG0384	phenazine biosynthesis protein PhzF
HV229_RS12285	COG2181	nitrate reductase activity
HV229_RS12290	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV229_RS12295	COG1140	nitrate reductase beta subunit
HV229_RS12300	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV229_RS12305	COG2223	nitrite transmembrane transporter activity
HV229_RS12340	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS12345	COG2864	formate dehydrogenase
HV229_RS12350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HV229_RS12370	COG1764	response to oxidative stress
HV229_RS12375	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS12380	COG2610	gluconate transmembrane transporter activity
HV229_RS12385	COG0824	Thioesterase
HV229_RS12385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV229_RS12395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV229_RS12400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV229_RS12410	COG4608	Belongs to the ABC transporter superfamily
HV229_RS12415	COG0444	Belongs to the ABC transporter superfamily
HV229_RS12420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV229_RS12425	COG0601	transmembrane transport
HV229_RS12430	COG0747	negative chemotaxis
HV229_RS12435	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV229_RS12450	COG0840	transmembrane signaling receptor activity
HV229_RS12460	COG4628	conserved protein (DUF2132)
HV229_RS12480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HV229_RS12485	COG1193	negative regulation of DNA recombination
HV229_RS12495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HV229_RS12500	COG0588	phosphoglycerate mutase activity
HV229_RS12510	COG0148	phosphopyruvate hydratase activity
HV229_RS12520	COG1227	inorganic diphosphatase activity
HV229_RS12525	COG0671	phosphoesterase, PA-phosphatase related
HV229_RS12530	COG0038	chloride channel
HV229_RS12635	COG3781	membrane
HV229_RS12660	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS12665	COG0583	DNA-binding transcription factor activity
HV229_RS12680	COG1846	Transcriptional regulator
HV229_RS12700	COG2814	Major facilitator Superfamily
HV229_RS12705	COG0410	ABC transporter
HV229_RS12710	COG1129	ABC transporter
HV229_RS12735	COG0339	signal peptide processing
HV229_RS12740	COG4221	oxidoreductase activity
HV229_RS12745	COG1802	Transcriptional regulator
HV229_RS12755	COG0246	Mannitol dehydrogenase
HV229_RS12760	COG0477	Major facilitator Superfamily
HV229_RS12765	COG1063	alcohol dehydrogenase
HV229_RS12770	COG4948	Mandelate Racemase Muconate Lactonizing
HV229_RS12785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV229_RS12800	COG0243	molybdopterin cofactor binding
HV229_RS12805	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS12810	COG3302	dmso reductase anchor subunit
HV229_RS12815	COG3381	protein complex oligomerization
HV229_RS12825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV229_RS12830	COG1940	carbohydrate kinase activity
HV229_RS12835	COG0583	DNA-binding transcription factor activity
HV229_RS12840	COG2814	Major facilitator Superfamily
HV229_RS12850	COG2205	protein histidine kinase activity
HV229_RS12855	COG0745	RESPONSE REGULATOR receiver
HV229_RS12870	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV229_RS12880	COG3591	Belongs to the peptidase S1B family
HV229_RS12895	COG0628	permease
HV229_RS12900	COG2814	Major facilitator Superfamily
HV229_RS12905	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV229_RS12910	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV229_RS12920	COG0531	amino acid
HV229_RS12930	COG3136	membrane protein required for alginate biosynthesis
HV229_RS12935	COG0745	RESPONSE REGULATOR receiver
HV229_RS12940	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV229_RS12950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV229_RS12975	COG2205	protein histidine kinase activity
HV229_RS12990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS12990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS12995	COG1482	cell wall glycoprotein biosynthetic process
HV229_RS13000	COG5339	Protein conserved in bacteria
HV229_RS13005	COG1609	Transcriptional regulator
HV229_RS13010	COG1263	PTS System
HV229_RS13010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS13015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV229_RS13025	COG0673	inositol 2-dehydrogenase activity
HV229_RS13075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV229_RS13085	COG0625	glutathione transferase activity
HV229_RS13090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV229_RS13105	COG3895	Periplasmic Protein
HV229_RS13130	COG1566	PFAM secretion protein HlyD family protein
HV229_RS13145	COG4989	oxidoreductase activity
HV229_RS13150	COG3313	Fe-S protein
HV229_RS13155	COG1309	transcriptional regulator
HV229_RS13160	COG1902	pentaerythritol trinitrate reductase activity
HV229_RS13165	COG0346	lactoylglutathione lyase activity
HV229_RS13175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV229_RS13180	COG0791	NLP P60 protein
HV229_RS13185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV229_RS13190	COG2814	Major facilitator Superfamily
HV229_RS13205	COG0583	DNA-binding transcription factor activity
HV229_RS13210	COG2814	Major facilitator Superfamily
HV229_RS13215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV229_RS13220	COG0307	riboflavin synthase, alpha
HV229_RS13245	COG0251	oxidation-reduction process
HV229_RS13265	COG3300	MHYT domain
HV229_RS13265	COG5001	Diguanylate cyclase
HV229_RS13270	COG3272	Protein of unknown function (DUF1722)
HV229_RS13275	COG0628	permease
HV229_RS13305	COG0583	DNA-binding transcription factor activity
HV229_RS13310	COG0477	Major facilitator Superfamily
HV229_RS13325	COG1942	4-Oxalocrotonate Tautomerase
HV229_RS13335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV229_RS13345	COG0251	oxidation-reduction process
HV229_RS13360	COG1114	Component of the transport system for branched-chain amino acids
HV229_RS13390	COG4977	sequence-specific DNA binding
HV229_RS13400	COG0386	Belongs to the glutathione peroxidase family
HV229_RS13435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV229_RS13450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV229_RS13460	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS13475	COG1113	amino acid transport
HV229_RS13485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV229_RS13495	COG0765	amino acid transport
HV229_RS13500	COG0765	amino acid transport
HV229_RS13510	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV229_RS13515	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS13525	COG2414	aldehyde ferredoxin oxidoreductase
HV229_RS13530	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS13565	COG1464	Belongs to the NlpA lipoprotein family
HV229_RS13570	COG2011	ABC-type metal ion transport system permease component
HV229_RS13590	COG1376	ErfK ybiS ycfS ynhG family protein
HV229_RS13605	COG0719	Fe-S assembly protein
HV229_RS13610	COG0396	ATPase activity
HV229_RS13615	COG0719	Fe-S assembly protein
HV229_RS13620	COG0316	Belongs to the HesB IscA family
HV229_RS13640	COG2050	protein possibly involved in aromatic compounds catabolism
HV229_RS13645	COG0247	lactate metabolic process
HV229_RS13645	COG0277	FAD linked oxidase domain protein
HV229_RS13650	COG0628	permease
HV229_RS13665	COG0738	Major facilitator superfamily
HV229_RS13670	COG2271	Major facilitator Superfamily
HV229_RS13685	COG4670	ketone body catabolic process
HV229_RS13690	COG1960	acyl-CoA dehydrogenase activity
HV229_RS13695	COG1917	Cupin 2, conserved barrel domain protein
HV229_RS13695	COG2207	Transcriptional regulator
HV229_RS13700	COG2086	electron transfer activity
HV229_RS13705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV229_RS13710	COG0644	oxidoreductase
HV229_RS13715	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV229_RS13720	COG0318	PFAM AMP-dependent synthetase and ligase
HV229_RS13725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV229_RS13725	COG0574	Belongs to the PEP-utilizing enzyme family
HV229_RS13735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV229_RS13740	COG4256	Hemin uptake protein
HV229_RS13745	COG4771	TonB-dependent receptor
HV229_RS13750	COG3720	iron ion transport
HV229_RS13755	COG4558	Periplasmic binding protein
HV229_RS13760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV229_RS13780	COG0791	NLP P60 protein
HV229_RS13790	COG0386	Belongs to the glutathione peroxidase family
HV229_RS13805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS13820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV229_RS13850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV229_RS13870	COG3137	Salt-induced outer membrane protein
HV229_RS13875	COG1105	Belongs to the carbohydrate kinase PfkB family
HV229_RS13880	COG3001	Fructosamine kinase
HV229_RS13890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV229_RS13900	COG1988	membrane-bound metal-dependent
HV229_RS13915	COG0753	catalase activity
HV229_RS13925	COG1486	melibiose metabolic process
HV229_RS13930	COG2169	Transcriptional regulator
HV229_RS13930	COG1917	Cupin 2, conserved barrel domain protein
HV229_RS13935	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV229_RS13940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV229_RS13945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV229_RS13950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV229_RS13960	COG0322	excinuclease ABC activity
HV229_RS13970	COG3678	ATP-independent chaperone mediated protein folding
HV229_RS14000	COG0708	Exodeoxyribonuclease III
HV229_RS14005	COG0398	Pfam SNARE associated Golgi protein
HV229_RS14010	COG0398	Pfam SNARE associated Golgi protein
HV229_RS14015	COG4134	Bacterial extracellular solute-binding protein
HV229_RS14020	COG4135	transport system, permease component
HV229_RS14025	COG4136	ATPase activity
HV229_RS14030	COG2897	thiosulfate sulfurtransferase activity
HV229_RS14035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV229_RS14040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV229_RS14045	COG0494	nUDIX hydrolase
HV229_RS14060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV229_RS14070	COG0778	Nitroreductase
HV229_RS14075	COG0616	signal peptide processing
HV229_RS14080	COG0252	asparaginase activity
HV229_RS14085	COG1335	isochorismatase
HV229_RS14090	COG2814	Major facilitator Superfamily
HV229_RS14095	COG1349	DNA-binding transcription factor activity
HV229_RS14100	COG0667	Aldo Keto reductase
HV229_RS14105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS14110	COG0191	fructose-bisphosphate aldolase activity
HV229_RS14115	COG1063	alcohol dehydrogenase
HV229_RS14120	COG2271	Major facilitator Superfamily
HV229_RS14125	COG1063	alcohol dehydrogenase
HV229_RS14140	COG3139	Protein of unknown function (DUF1315)
HV229_RS14160	COG0656	L-ascorbic acid biosynthetic process
HV229_RS14175	COG3713	MltA-interacting MipA family protein
HV229_RS14180	COG2766	serine protein kinase
HV229_RS14190	COG0110	maltose O-acetyltransferase activity
HV229_RS14200	COG2226	methyltransferase
HV229_RS14205	COG2199	diguanylate cyclase activity
HV229_RS14210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV229_RS14220	COG2207	Transcriptional regulator
HV229_RS14225	COG2807	transmembrane transport
HV229_RS14230	COG0504	CTP synthase activity
HV229_RS14235	COG3189	MarR family transcriptional regulator
HV229_RS14240	COG3042	response to heat
HV229_RS14245	COG2203	Gaf domain
HV229_RS14245	COG2199	diguanylate cyclase activity
HV229_RS14260	COG2261	transglycosylase associated protein
HV229_RS14265	COG3383	formate dehydrogenase (NAD+) activity
HV229_RS14280	COG3615	Tellurite resistance protein tehB
HV229_RS14290	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV229_RS14295	COG1124	(ABC) transporter
HV229_RS14305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV229_RS14310	COG0601	transmembrane transport
HV229_RS14315	COG0747	negative chemotaxis
HV229_RS14320	COG4771	TonB-dependent receptor
HV229_RS14340	COG1956	GAF domain-containing protein
HV229_RS14345	COG2995	paraquat-inducible protein a
HV229_RS14350	COG3008	intermembrane lipid transfer
HV229_RS14555	COG3772	lysozyme
HV229_RS14635	COG1484	DNA-dependent DNA replication
HV229_RS14690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV229_RS14710	COG0582	viral genome integration into host DNA
HV229_RS14720	COG1276	copper resistance
HV229_RS14725	COG2372	response to copper ion
HV229_RS14735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV229_RS14740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV229_RS14745	COG1770	oligopeptidase
HV229_RS14750	COG2979	Protein of unknown function (DUF533)
HV229_RS14760	COG3141	response to X-ray
HV229_RS14770	COG0800	Aldolase
HV229_RS14775	COG0129	dihydroxy-acid dehydratase activity
HV229_RS14780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV229_RS14785	COG1737	Transcriptional regulator
HV229_RS14795	COG1560	Kdo2-lipid A biosynthetic process
HV229_RS14800	COG0739	heme binding
HV229_RS14805	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV229_RS14815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV229_RS14840	COG2850	peptidyl-arginine hydroxylation
HV229_RS14865	COG3459	Glycosyltransferase 36 associated
HV229_RS14890	COG1289	transmembrane transporter activity
HV229_RS14905	COG1278	Cold shock
HV229_RS14920	COG1177	transmembrane transport
HV229_RS14930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV229_RS14940	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV229_RS14945	COG1136	(ABC) transporter
HV229_RS14950	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV229_RS14955	COG4763	Acyl-transferase
HV229_RS14960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV229_RS14965	COG1388	LysM domain
HV229_RS14965	COG1376	ErfK ybiS ycfS ynhG family protein
HV229_RS14975	COG1309	transcriptional regulator
HV229_RS14985	COG3134	Outer membrane lipoprotein
HV229_RS14990	COG1252	NADH dehydrogenase
HV229_RS15015	COG5633	Lipoprotein
HV229_RS15020	COG0537	adenosine 5'-monophosphoramidase activity
HV229_RS15025	COG4773	Receptor
HV229_RS15035	COG0534	Mate efflux family protein
HV229_RS15045	COG0582	viral genome integration into host DNA
HV229_RS15065	COG3423	Transcriptional regulator
HV229_RS15090	COG3039	Transposase
HV229_RS15095	COG0583	DNA-binding transcription factor activity
HV229_RS15115	COG0477	Major facilitator Superfamily
HV229_RS15120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV229_RS15125	COG0006	proline dipeptidase activity
HV229_RS15135	COG0084	hydrolase, TatD family'
HV229_RS15140	COG0470	DNA polymerase III
HV229_RS15150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV229_RS15155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV229_RS15165	COG3121	Chaperone
HV229_RS15190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV229_RS15225	COG1399	metal-binding, possibly nucleic acid-binding protein
HV229_RS15235	COG0564	pseudouridine synthase activity
HV229_RS15240	COG1530	ribonuclease E activity
HV229_RS15270	COG4786	Flagellar basal body rod
HV229_RS15275	COG4787	bacterial-type flagellum-dependent cell motility
HV229_RS15290	COG1558	bacterial-type flagellum-dependent cell motility
HV229_RS15330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV229_RS15370	COG3038	cytochrome b561
HV229_RS15385	COG1560	Kdo2-lipid A biosynthetic process
HV229_RS15400	COG5645	(Lipo)protein
HV229_RS15420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV229_RS15475	COG3381	protein complex oligomerization
HV229_RS15500	COG1702	phosphate starvation-inducible protein PhoH
HV229_RS15525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV229_RS15530	COG0506	proline dehydrogenase activity
HV229_RS15530	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV229_RS15530	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV229_RS15535	COG3755	Protein conserved in bacteria
HV229_RS15540	COG1309	transcriptional regulator
HV229_RS15550	COG3729	General stress protein
HV229_RS15570	COG0640	Transcriptional regulator
HV229_RS15580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV229_RS15585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV229_RS15585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV229_RS15635	COG0813	purine-nucleoside phosphorylase activity
HV229_RS15640	COG2246	polysaccharide biosynthetic process
HV229_RS15735	COG3039	Transposase
HV229_RS15925	COG0494	nUDIX hydrolase
HV229_RS15965	COG3179	chitinase
HV229_RS16025	COG0305	Participates in initiation and elongation during chromosome replication
HV229_RS16050	COG1396	sequence-specific DNA binding
HV229_RS16060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV229_RS16090	COG4166	transmembrane transport
HV229_RS16095	COG0670	Belongs to the BI1 family
HV229_RS16140	COG2920	part of a sulfur-relay system
HV229_RS16165	COG1832	CoA-binding protein
HV229_RS16180	COG0210	DNA helicase
HV229_RS16185	COG3304	Inner membrane component domain
HV229_RS16190	COG1289	transmembrane transporter activity
HV229_RS16195	COG3070	regulator of competence-specific genes
HV229_RS16215	COG1067	ATP-dependent peptidase activity
HV229_RS16225	COG3130	regulation of translation
HV229_RS16230	COG3009	Protein conserved in bacteria
HV229_RS16235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV229_RS16235	COG3008	intermembrane lipid transfer
HV229_RS16240	COG2995	paraquat-inducible protein a
HV229_RS16245	COG0488	(ABC) transporter
HV229_RS16255	COG3217	Mosc domain protein beta barrel domain protein
HV229_RS16255	COG0633	Ferredoxin
HV229_RS16270	COG0431	NADPH-dependent FMN reductase
HV229_RS16275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV229_RS16285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV229_RS16295	COG0308	aminopeptidase N
HV229_RS16315	COG1448	Aminotransferase
HV229_RS16320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV229_RS16325	COG3108	Peptidase M15
HV229_RS16330	COG2989	Protein conserved in bacteria
HV229_RS16340	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV229_RS16350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV229_RS16355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV229_RS16360	COG3173	Aminoglycoside phosphotransferase
HV229_RS16375	COG3214	Protein conserved in bacteria
HV229_RS16390	COG2333	competence protein COMEC
HV229_RS16390	COG0658	competence protein
HV229_RS16395	COG0776	regulation of translation
HV229_RS16400	COG0539	negative regulation of cytoplasmic translation
HV229_RS16420	COG2323	membrane
HV229_RS16425	COG1944	ATP diphosphatase activity
HV229_RS16430	COG2116	formate transmembrane transporter activity
HV229_RS16435	COG1882	Formate acetyltransferase
HV229_RS16440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV229_RS16460	COG3959	Transketolase, thiamine diphosphate binding domain
HV229_RS16465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV229_RS16470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS16480	COG1335	isochorismatase
HV229_RS16485	COG3302	dmso reductase anchor subunit
HV229_RS16490	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS16495	COG0243	molybdopterin cofactor binding
HV229_RS16505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV229_RS16525	COG0492	ferredoxin-NADP+ reductase activity
HV229_RS16530	COG4988	ABC transporter
HV229_RS16535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV229_RS16550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV229_RS16555	COG0583	DNA-binding transcription factor activity
HV229_RS16565	COG1335	isochorismatase
HV229_RS16575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV229_RS16585	COG1177	transmembrane transport
HV229_RS16590	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV229_RS16595	COG3842	ATPase activity
HV229_RS16600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV229_RS16640	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS16645	COG3226	Transcriptional regulator
HV229_RS16650	COG0738	Major facilitator superfamily
HV229_RS16655	COG0561	phosphatase activity
HV229_RS16665	COG2814	Major facilitator Superfamily
HV229_RS16670	COG0671	phosphoesterase, PA-phosphatase related
HV229_RS16675	COG1349	DNA-binding transcription factor activity
HV229_RS16680	COG1686	Belongs to the peptidase S11 family
HV229_RS16685	COG0625	glutathione transferase activity
HV229_RS16690	COG2133	pyrroloquinoline quinone binding
HV229_RS16725	COG1446	asparaginase
HV229_RS16735	COG0303	'Molybdopterin
HV229_RS16740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV229_RS16745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV229_RS16750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV229_RS16755	COG1882	Formate acetyltransferase
HV229_RS16760	COG0561	phosphatase activity
HV229_RS16770	COG0488	(ABC) transporter
HV229_RS16775	COG1376	ErfK ybiS ycfS ynhG family protein
HV229_RS16780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV229_RS16795	COG2194	sulfuric ester hydrolase activity
HV229_RS16800	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV229_RS16815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV229_RS16820	COG0765	amino acid transport
HV229_RS16825	COG1126	abc transporter atp-binding protein
HV229_RS16830	COG0668	transmembrane transport
HV229_RS16845	COG4774	siderophore transport
HV229_RS16855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV229_RS16865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV229_RS16870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV229_RS16880	COG0513	Belongs to the DEAD box helicase family
HV229_RS16885	COG1309	transcriptional regulator
HV229_RS16895	COG1131	(ABC) transporter
HV229_RS16900	COG0842	Transport permease protein
HV229_RS16905	COG0842	Transport permease protein
HV229_RS16915	COG3568	Endonuclease Exonuclease Phosphatase
HV229_RS16920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV229_RS16925	COG0392	lysyltransferase activity
HV229_RS16930	COG0670	Belongs to the BI1 family
HV229_RS16935	COG0314	molybdopterin synthase activity
HV229_RS16940	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV229_RS16950	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV229_RS16975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV229_RS17000	COG1881	PFAM PEBP family protein
HV229_RS17030	COG4677	pectinesterase activity
HV229_RS17050	COG4796	Type ii and iii secretion system protein
HV229_RS17070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV229_RS17075	COG1459	type II secretion system
HV229_RS17085	COG0739	heme binding
HV229_RS17085	COG0741	lytic transglycosylase activity
HV229_RS17085	COG1196	nuclear chromosome segregation
HV229_RS17100	COG0561	phosphatase activity
HV229_RS17110	COG4149	molybdate abc transporter
HV229_RS17115	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV229_RS17125	COG3585	molybdate ion transport
HV229_RS17125	COG2005	Transcriptional regulator
HV229_RS17130	COG1119	ATPase activity
HV229_RS17135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV229_RS17140	COG1085	galactose-1-phosphate uridylyltransferase
HV229_RS17150	COG2017	converts alpha-aldose to the beta-anomer
HV229_RS17160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV229_RS17170	COG1230	cation diffusion facilitator family transporter
HV229_RS17175	COG3201	nicotinamide mononucleotide transporter
HV229_RS17215	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV229_RS17220	COG2885	chlorophyll binding
HV229_RS17230	COG3064	Membrane
HV229_RS17235	COG0848	biopolymer transport protein
HV229_RS17240	COG0811	peptide transport
HV229_RS17245	COG0824	Thioesterase
HV229_RS17250	COG3790	cyd operon protein YbgE
HV229_RS17255	COG4890	Cyd operon protein YbgT
HV229_RS17260	COG1294	oxidase, subunit
HV229_RS17265	COG1271	oxidase subunit
HV229_RS17270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV229_RS17280	COG4865	methylaspartate mutase activity
HV229_RS17285	COG3799	methylaspartate ammonia-lyase activity
HV229_RS17300	COG1301	dicarboxylic acid transport
HV229_RS17310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS17310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS17320	COG0583	DNA-binding transcription factor activity
HV229_RS17325	COG1648	precorrin-2 dehydrogenase activity
HV229_RS17325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV229_RS17335	COG3395	kinase activity
HV229_RS17340	COG0235	Class ii aldolase
HV229_RS17345	COG1349	DNA-binding transcription factor activity
HV229_RS17350	COG3622	Belongs to the hyi family
HV229_RS17355	COG3246	L-lysine catabolic process to acetate
HV229_RS17375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV229_RS17385	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV229_RS17390	COG0567	Dehydrogenase, E1 component
HV229_RS17395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV229_RS17400	COG1053	succinate dehydrogenase
HV229_RS17405	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV229_RS17410	COG2009	succinate dehydrogenase
HV229_RS17420	COG3180	Ammonia monooxygenase
HV229_RS17450	COG1984	allophanate hydrolase subunit 2
HV229_RS17455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV229_RS17460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV229_RS17470	COG5464	transposase or invertase
HV229_RS17505	COG2205	protein histidine kinase activity
HV229_RS17510	COG0745	RESPONSE REGULATOR receiver
HV229_RS17520	COG1982	Orn Lys Arg decarboxylase major
HV229_RS17525	COG0531	amino acid
HV229_RS17530	COG0033	Phosphoglucomutase
HV229_RS17535	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV229_RS17540	COG0596	Alpha beta hydrolase
HV229_RS17550	COG0716	FMN binding
HV229_RS17560	COG0735	belongs to the Fur family
HV229_RS17565	COG0583	DNA-binding transcription factor activity
HV229_RS17570	COG1053	succinate dehydrogenase
HV229_RS17595	COG1609	Transcriptional regulator
HV229_RS17605	COG1653	transport
HV229_RS17625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV229_RS17630	COG1846	Transcriptional regulator
HV229_RS17630	COG1940	carbohydrate kinase activity
HV229_RS17635	COG0647	UMP catabolic process
HV229_RS17640	COG0367	asparagine synthase
HV229_RS17680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV229_RS17690	COG1702	phosphate starvation-inducible protein PhoH
HV229_RS17695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV229_RS17715	COG0765	amino acid transport
HV229_RS17720	COG0765	amino acid transport
HV229_RS17725	COG1126	abc transporter atp-binding protein
HV229_RS17735	COG2888	peptidyl-tyrosine sulfation
HV229_RS17750	COG1466	dna polymerase III delta subunit
HV229_RS17770	COG0799	negative regulation of ribosome biogenesis
HV229_RS17780	COG0768	penicillin binding
HV229_RS17785	COG0772	Belongs to the SEDS family
HV229_RS17790	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV229_RS17795	COG1686	Belongs to the peptidase S11 family
HV229_RS17820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV229_RS17840	COG3069	C4-dicarboxylate transmembrane transporter activity
HV229_RS17845	COG4565	transcriptional regulatory protein
HV229_RS17850	COG3290	protein histidine kinase activity
HV229_RS17855	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV229_RS17865	COG2301	Belongs to the HpcH HpaI aldolase family
HV229_RS17870	COG3051	citrate lyase alpha subunit
HV229_RS17885	COG0471	metal ion transport
HV229_RS17890	COG3719	Belongs to the RNase T2 family
HV229_RS17905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV229_RS17915	COG3634	alkyl hydroperoxide reductase activity
HV229_RS17925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV229_RS17930	COG0583	DNA-binding transcription factor activity
HV229_RS17935	COG3969	phosphoadenosine phosphosulfate
HV229_RS17940	COG1475	DNA binding
HV229_RS17945	COG0436	Aminotransferase
HV229_RS17950	COG0371	Dehydrogenase
HV229_RS17955	COG2879	small protein
HV229_RS17960	COG1966	Carbon starvation protein
HV229_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
HV229_RS17975	COG3433	isochorismatase activity
HV229_RS17975	COG1535	isochorismatase
HV229_RS17980	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV229_RS17985	COG1169	isochorismate synthase
HV229_RS17990	COG4592	Periplasmic binding protein
HV229_RS18000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV229_RS18005	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV229_RS18010	COG1120	ATPase activity
HV229_RS18015	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV229_RS18020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV229_RS18020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV229_RS18025	COG3251	PFAM MbtH domain protein
HV229_RS18030	COG2382	esterase
HV229_RS18035	COG4771	TonB-dependent receptor
HV229_RS18045	COG1879	ABC-type sugar transport system periplasmic component
HV229_RS18055	COG1129	ABC transporter
HV229_RS18060	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS18065	COG2390	Transcriptional regulator
HV229_RS18070	COG3959	Transketolase, thiamine diphosphate binding domain
HV229_RS18075	COG3958	Transketolase
HV229_RS18085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV229_RS18120	COG2315	Protein conserved in bacteria
HV229_RS18130	COG0668	transmembrane transport
HV229_RS18150	COG2211	Major facilitator Superfamily
HV229_RS18155	COG1113	amino acid transport
HV229_RS18175	COG5001	Diguanylate cyclase
HV229_RS18175	COG3300	MHYT domain
HV229_RS18190	COG3039	Transposase
HV229_RS18195	COG3059	membrane
HV229_RS18205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV229_RS18210	COG2207	Transcriptional regulator
HV229_RS18215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV229_RS18220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS18225	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS18230	COG1538	Outer membrane efflux protein
HV229_RS18235	COG0745	RESPONSE REGULATOR receiver
HV229_RS18240	COG5002	protein histidine kinase activity
HV229_RS18260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV229_RS18260	COG0321	lipoyl(octanoyl) transferase activity
HV229_RS18265	COG0243	molybdopterin cofactor binding
HV229_RS18270	COG3005	denitrification pathway
HV229_RS18290	COG3005	denitrification pathway
HV229_RS18295	COG0745	RESPONSE REGULATOR receiver
HV229_RS18300	COG1879	ABC-type sugar transport system periplasmic component
HV229_RS18305	COG0784	Response regulator, receiver
HV229_RS18305	COG2205	protein histidine kinase activity
HV229_RS18305	COG2198	Histidine kinase
HV229_RS18370	COG2501	S4 domain
HV229_RS18375	COG1988	membrane-bound metal-dependent
HV229_RS18385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV229_RS18395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV229_RS18400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV229_RS18405	COG0549	Belongs to the carbamate kinase family
HV229_RS18415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV229_RS18420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV229_RS18425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV229_RS18430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV229_RS18435	COG3257	ureidoglycine aminohydrolase activity
HV229_RS18440	COG1929	Belongs to the glycerate kinase type-1 family
HV229_RS18445	COG2233	PERMEase
HV229_RS18455	COG1953	Uracil, thiamine, allantoin
HV229_RS18465	COG2084	Dehydrogenase
HV229_RS18470	COG3622	Belongs to the hyi family
HV229_RS18475	COG3960	tartronate-semialdehyde synthase activity
HV229_RS18495	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HV229_RS18500	COG2011	ABC-type metal ion transport system permease component
HV229_RS18510	COG1464	Belongs to the NlpA lipoprotein family
HV229_RS18520	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV229_RS18525	COG4181	ATPase activity
HV229_RS18530	COG2755	lipolytic protein G-D-S-L family
HV229_RS18535	COG0300	oxidoreductase activity
HV229_RS18540	COG3118	belongs to the thioredoxin family
HV229_RS18545	COG0390	transport system, permease component
HV229_RS18550	COG4619	ABC transporter
HV229_RS18555	COG0330	HflC and HflK could
HV229_RS18560	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV229_RS18580	COG4771	TonB-dependent receptor
HV229_RS18585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV229_RS18595	COG3721	Heme iron utilization protein
HV229_RS18605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV229_RS18620	COG3735	TraB family
HV229_RS18625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV229_RS18635	COG2223	nitrite transmembrane transporter activity
HV229_RS18640	COG4651	solute:proton antiporter activity
HV229_RS18640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV229_RS18645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS18690	COG2832	Protein of unknown function (DUF454)
HV229_RS18695	COG3923	Primosomal replication protein n
HV229_RS18705	COG1196	nuclear chromosome segregation
HV229_RS18705	COG3264	Mechanosensitive ion channel
HV229_RS18710	COG1309	transcriptional regulator
HV229_RS18715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS18720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV229_RS18735	COG0110	maltose O-acetyltransferase activity
HV229_RS18755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV229_RS18760	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV229_RS18765	COG2364	Membrane
HV229_RS18770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV229_RS18790	COG3695	enzyme binding
HV229_RS18795	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV229_RS18800	COG1946	Acyl-CoA thioesterase
HV229_RS18805	COG0004	ammonium transporteR
HV229_RS18810	COG0347	Belongs to the P(II) protein family
HV229_RS18815	COG1132	(ABC) transporter
HV229_RS18820	COG1132	(ABC) transporter
HV229_RS18825	COG1522	sequence-specific DNA binding
HV229_RS18840	COG4533	DNA binding
HV229_RS18850	COG0824	Thioesterase
HV229_RS18855	COG1555	photosystem II stabilization
HV229_RS18860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV229_RS18865	COG0776	regulation of translation
HV229_RS18870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV229_RS18890	COG0271	Belongs to the BolA IbaG family
HV229_RS18895	COG3056	Lipoprotein
HV229_RS18900	COG2223	nitrite transmembrane transporter activity
HV229_RS18905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV229_RS18910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV229_RS18915	COG1845	cytochrome c oxidase, subunit III
HV229_RS18920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV229_RS18945	COG2814	Major facilitator Superfamily
HV229_RS18980	COG0142	geranyltranstransferase activity
HV229_RS18990	COG0667	Aldo Keto reductase
HV229_RS18995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV229_RS19000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV229_RS19015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV229_RS19015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV229_RS19025	COG4238	major outer membrane lipoprotein
HV229_RS19030	COG3248	Nucleoside-binding outer membrane protein
HV229_RS19045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV229_RS19050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV229_RS19055	COG1862	Preprotein translocase
HV229_RS19065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV229_RS19075	COG0450	alkyl hydroperoxide reductase
HV229_RS19090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV229_RS19100	COG1335	isochorismatase
HV229_RS19105	COG0583	DNA-binding transcription factor activity
HV229_RS19110	COG0366	Alpha amylase catalytic
HV229_RS19125	COG5002	protein histidine kinase activity
HV229_RS19135	COG0420	3'-5' exonuclease activity
HV229_RS19140	COG0419	ATPase involved in DNA repair
HV229_RS19145	COG2814	Major facilitator Superfamily
HV229_RS19150	COG1940	carbohydrate kinase activity
HV229_RS19165	COG4126	flavin adenine dinucleotide binding
HV229_RS19185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV229_RS19190	COG3706	GGDEF domain
HV229_RS19200	COG1785	Belongs to the alkaline phosphatase family
HV229_RS19215	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV229_RS19235	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV229_RS19240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV229_RS19245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV229_RS19255	COG0113	porphobilinogen synthase activity
HV229_RS19260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HV229_RS19265	COG1215	transferase activity, transferring glycosyl groups
HV229_RS19290	COG2271	Major facilitator Superfamily
HV229_RS19295	COG1840	ABC-type Fe3 transport system, periplasmic component
HV229_RS19305	COG3842	ATPase activity
HV229_RS19310	COG2040	homocysteine
HV229_RS19315	COG0833	amino acid
HV229_RS19320	COG2814	Major facilitator Superfamily
HV229_RS19355	COG1414	Transcriptional regulator
HV229_RS19385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV229_RS19400	COG1609	Transcriptional regulator
HV229_RS19425	COG2079	MmgE PrpD family protein
HV229_RS19430	COG0372	Belongs to the citrate synthase family
HV229_RS19450	COG1280	lysine exporter protein (LysE YggA)
HV229_RS19455	COG3706	GGDEF domain
HV229_RS19460	COG0348	domain, Protein
HV229_RS19480	COG0840	transmembrane signaling receptor activity
HV229_RS19495	COG3069	C4-dicarboxylate transmembrane transporter activity
HV229_RS19500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV229_RS19510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV229_RS19515	COG0693	protein deglycase activity
HV229_RS19565	COG1136	(ABC) transporter
HV229_RS19575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HV229_RS19580	COG0531	amino acid
HV229_RS19585	COG0174	glutamine synthetase
HV229_RS19590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV229_RS19595	COG1917	Cupin 2, conserved barrel domain protein
HV229_RS19595	COG1396	sequence-specific DNA binding
HV229_RS19600	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS19605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV229_RS19620	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HV229_RS19625	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV229_RS19630	COG1999	signal sequence binding
HV229_RS19635	COG1773	rubredoxin
HV229_RS19640	COG1271	oxidase subunit
HV229_RS19645	COG1294	oxidase, subunit
HV229_RS19705	COG0758	DNA mediated transformation
HV229_RS19710	COG0546	phosphoglycolate phosphatase activity
HV229_RS19715	COG0582	viral genome integration into host DNA
HV229_RS19720	COG0582	viral genome integration into host DNA
HV229_RS19780	COG3344	reverse transcriptase
HV229_RS19790	COG2826	transposase and inactivated derivatives, IS30 family
HV229_RS19805	COG0656	L-ascorbic acid biosynthetic process
HV229_RS19815	COG2433	Pfam Transposase IS66
HV229_RS19820	COG3436	PFAM IS66 Orf2 family protein
HV229_RS19880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV229_RS19910	COG3596	GTP binding
HV229_RS19920	COG2378	regulation of single-species biofilm formation
HV229_RS19930	COG2378	regulation of single-species biofilm formation
HV229_RS19950	COG2003	Belongs to the UPF0758 family
HV229_RS19980	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV229_RS20020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV229_RS20030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV229_RS20055	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV229_RS20075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HV229_RS20080	COG1191	sigma factor activity
HV229_RS20105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV229_RS20110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV229_RS20130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV229_RS20135	COG1256	bacterial-type flagellum assembly
HV229_RS20135	COG4786	Flagellar basal body rod
HV229_RS20155	COG4786	Flagellar basal body rod
HV229_RS20160	COG4787	bacterial-type flagellum-dependent cell motility
HV229_RS20175	COG1558	bacterial-type flagellum-dependent cell motility
HV229_RS20220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV229_RS20240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV229_RS20250	COG1677	Flagellar hook-basal body complex protein FliE
HV229_RS20275	COG1987	bacterial-type flagellum assembly
HV229_RS20280	COG1684	flagellar biosynthetic protein fliR
HV229_RS20285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HV229_RS20295	COG0791	NLP P60 protein
HV229_RS20300	COG3034	peptidoglycan biosynthetic process
HV229_RS20305	COG0121	glutamine amidotransferase
HV229_RS20315	COG1960	acyl-CoA dehydrogenase activity
HV229_RS20320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV229_RS20330	COG2200	EAL domain
HV229_RS20345	COG3539	Fimbrial protein
HV229_RS20355	COG3121	Chaperone
HV229_RS20360	COG3188	usher protein
HV229_RS20370	COG3539	Fimbrial protein
HV229_RS20375	COG3039	Transposase
HV229_RS20395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV229_RS20405	COG2226	methyltransferase
HV229_RS20415	COG1388	LysM domain
HV229_RS20415	COG0741	lytic transglycosylase activity
HV229_RS20420	COG2226	methyltransferase
HV229_RS20430	COG2814	Major facilitator Superfamily
HV229_RS20435	COG0583	DNA-binding transcription factor activity
HV229_RS20470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV229_RS20480	COG2011	ABC-type metal ion transport system permease component
HV229_RS20485	COG1464	Belongs to the NlpA lipoprotein family
HV229_RS20495	COG1720	tRNA m6t6A37 methyltransferase activity
HV229_RS20505	COG0791	NLP P60 protein
HV229_RS20510	COG3015	lipoprotein NlpE involved in copper resistance
HV229_RS20515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV229_RS20530	COG4568	rho-dependent transcription termination
HV229_RS20540	COG0346	lactoylglutathione lyase activity
HV229_RS20580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV229_RS20585	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV229_RS20600	COG0575	Belongs to the CDS family
HV229_RS20610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV229_RS20655	COG3835	regulator
HV229_RS20680	COG2860	membrane
HV229_RS20705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV229_RS20710	COG1120	ATPase activity
HV229_RS20715	COG4774	siderophore transport
HV229_RS20720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV229_RS20725	COG1643	Atp-dependent helicase
HV229_RS20730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV229_RS20750	COG0617	tRNA 3'-terminal CCA addition
HV229_RS20755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV229_RS20775	COG0726	polysaccharide deacetylase
HV229_RS20780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS20785	COG0842	Transport permease protein
HV229_RS20790	COG1131	(ABC) transporter
HV229_RS20795	COG0288	reversible hydration of carbon dioxide
HV229_RS20800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV229_RS20805	COG4993	Dehydrogenase
HV229_RS20855	COG3064	Membrane
HV229_RS20870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV229_RS20875	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV229_RS20880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV229_RS20895	COG2211	Major facilitator Superfamily
HV229_RS20900	COG3940	Belongs to the glycosyl hydrolase 43 family
HV229_RS20905	COG3725	Membrane protein required for beta-lactamase induction
HV229_RS20920	COG4969	Belongs to the N-Me-Phe pilin family
HV229_RS20925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV229_RS20930	COG1459	type II secretion system
HV229_RS20940	COG0237	dephospho-CoA kinase activity
HV229_RS20955	COG0494	nUDIX hydrolase
HV229_RS20975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV229_RS20980	COG0849	cell division
HV229_RS20990	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV229_RS21005	COG0772	Belongs to the SEDS family
HV229_RS21010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV229_RS21020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV229_RS21025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV229_RS21030	COG0768	penicillin binding
HV229_RS21060	COG0028	Belongs to the TPP enzyme family
HV229_RS21095	COG2814	Major facilitator Superfamily
HV229_RS21115	COG1178	ABC-type Fe3 transport system permease component
HV229_RS21125	COG0586	Pfam SNARE associated Golgi protein
HV229_RS21145	COG0235	Class ii aldolase
HV229_RS21155	COG0417	DNA replication proofreading
HV229_RS21165	COG0564	pseudouridine synthase activity
HV229_RS21225	COG2271	Major facilitator Superfamily
HV229_RS21235	COG0644	oxidoreductase
HV229_RS21285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV229_RS21290	COG0505	Belongs to the CarA family
HV229_RS21300	COG1609	Transcriptional regulator
HV229_RS21315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS21315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS21320	COG3715	PTS system
HV229_RS21325	COG3716	PTS system mannose fructose sorbose family IID component
HV229_RS21335	COG2140	Oxalate decarboxylase
HV229_RS21350	COG1047	Peptidyl-prolyl cis-trans
HV229_RS21365	COG0196	riboflavin kinase activity
HV229_RS21375	COG0583	DNA-binding transcription factor activity
HV229_RS21395	COG0641	radical SAM
HV229_RS21400	COG3119	arylsulfatase activity
HV229_RS21445	COG0443	Heat shock 70 kDa protein
HV229_RS21450	COG1584	GPR1 FUN34 yaaH family protein
HV229_RS21460	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV229_RS21470	COG1115	amino acid carrier protein
HV229_RS21480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV229_RS21490	COG0460	homoserine dehydrogenase
HV229_RS21490	COG0527	aspartate kinase activity
HV229_RS21500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV229_RS21510	COG0745	RESPONSE REGULATOR receiver
HV229_RS21515	COG4452	Inner membrane protein CreD
HV229_RS21520	COG2205	protein histidine kinase activity
HV229_RS21525	COG0745	RESPONSE REGULATOR receiver
HV229_RS21530	COG3045	CreA protein
HV229_RS21535	COG3708	Transcriptional regulator
HV229_RS21535	COG2207	Transcriptional regulator
HV229_RS21555	COG0741	lytic transglycosylase activity
HV229_RS21560	COG0488	(ABC) transporter
HV229_RS21575	COG0560	Phosphoserine phosphatase
HV229_RS21580	COG3726	membrane protein affecting hemolysin expression
HV229_RS21610	COG1328	CTP reductase activity
HV229_RS21615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV229_RS21620	COG0084	hydrolase, TatD family'
HV229_RS21625	COG4667	esterase of the alpha-beta hydrolase superfamily
HV229_RS21630	COG5487	UPF0391 membrane protein
HV229_RS21635	COG2823	Periplasmic or secreted lipoprotein
HV229_RS21645	COG1011	Hydrolase
HV229_RS21650	COG0456	acetyltransferase
HV229_RS21655	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV229_RS21685	COG3706	GGDEF domain
HV229_RS21690	COG4114	ferric iron reductase
HV229_RS21695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV229_RS21700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV229_RS21705	COG2197	response regulator
HV229_RS21710	COG2197	response regulator
HV229_RS21715	COG2966	Psort location CytoplasmicMembrane, score
HV229_RS21730	COG1484	DNA-dependent DNA replication
HV229_RS21750	COG1063	alcohol dehydrogenase
HV229_RS21755	COG1802	Transcriptional regulator
HV229_RS21760	COG2271	Major facilitator Superfamily
HV229_RS21770	COG0840	transmembrane signaling receptor activity
HV229_RS21780	COG1966	Carbon starvation protein
HV229_RS21785	COG2879	small protein
HV229_RS21790	COG0523	cobalamin synthesis protein
HV229_RS21805	COG5457	Domain of unknown function (DUF1127)
HV229_RS21810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV229_RS21815	COG5464	transposase or invertase
HV229_RS21815	COG5464	transposase or invertase
HV229_RS21820	COG1917	Cupin 2, conserved barrel domain protein
HV229_RS21820	COG2207	Transcriptional regulator
HV229_RS21835	COG0626	cystathionine gamma-synthase activity
HV229_RS21840	COG1301	dicarboxylic acid transport
HV229_RS21860	COG2733	membrane
HV229_RS21865	COG0477	Major facilitator Superfamily
HV229_RS21875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV229_RS21885	COG2186	Transcriptional regulator
HV229_RS21890	COG0246	Mannitol dehydrogenase
HV229_RS21900	COG2610	gluconate transmembrane transporter activity
HV229_RS21905	COG1556	Lactate utilization protein
HV229_RS21910	COG1139	Iron-sulfur cluster binding protein
HV229_RS21915	COG0247	lactate metabolic process
HV229_RS21920	COG1620	l-lactate permease
HV229_RS21965	COG1012	belongs to the aldehyde dehydrogenase family
HV229_RS21970	COG2963	transposase activity
HV229_RS22040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV229_RS22050	COG2375	cellular response to nickel ion
HV229_RS22055	COG1695	Transcriptional regulator
HV229_RS22060	COG0840	transmembrane signaling receptor activity
HV229_RS22070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV229_RS22075	COG1609	Transcriptional regulator
HV229_RS22080	COG3250	beta-galactosidase activity
HV229_RS22085	COG2731	YhcH YjgK YiaL family protein
HV229_RS22090	COG0531	amino acid
HV229_RS22095	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HV229_RS22100	COG0366	Alpha amylase catalytic
HV229_RS22105	COG0395	ABC-type sugar transport system, permease component
HV229_RS22135	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV229_RS22135	COG1902	pentaerythritol trinitrate reductase activity
HV229_RS22145	COG1451	nucleotide metabolic process
HV229_RS22150	COG0673	inositol 2-dehydrogenase activity
HV229_RS22170	COG2721	sulfolactate sulfo-lyase activity
HV229_RS22180	COG2271	Major facilitator Superfamily
HV229_RS22185	COG2186	Transcriptional regulator
HV229_RS22190	COG0586	Pfam SNARE associated Golgi protein
HV229_RS22200	COG1422	Protein of unknown function (DUF1090)
HV229_RS22205	COG4575	ribosome binding
HV229_RS22210	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV229_RS22220	COG2259	Doxx family
HV229_RS22225	COG0435	Glutathione S-transferase
HV229_RS22230	COG3152	Membrane
HV229_RS22235	COG0583	DNA-binding transcription factor activity
HV229_RS22240	COG1741	Belongs to the pirin family
HV229_RS22255	COG0814	amino acid
HV229_RS22260	COG1760	l-serine dehydratase
HV229_RS22265	COG0251	oxidation-reduction process
HV229_RS22270	COG1882	Formate acetyltransferase
HV229_RS22290	COG0583	DNA-binding transcription factor activity
HV229_RS22300	COG1929	Belongs to the glycerate kinase type-1 family
HV229_RS22305	COG2084	Dehydrogenase
HV229_RS22315	COG2271	Major facilitator Superfamily
HV229_RS22320	COG2721	sulfolactate sulfo-lyase activity
HV229_RS22325	COG1349	DNA-binding transcription factor activity
HV229_RS22335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS22345	COG3716	PTS system mannose fructose sorbose family IID component
HV229_RS22350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS22355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV229_RS22360	COG2222	sugar isomerase
HV229_RS22370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV229_RS22375	COG3715	PTS system
HV229_RS22380	COG3716	PTS system mannose fructose sorbose family IID component
HV229_RS22385	COG0363	glucosamine-6-phosphate deaminase activity
HV229_RS22395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV229_RS22415	COG2823	Periplasmic or secreted lipoprotein
HV229_RS22420	COG0702	epimerase
HV229_RS22435	COG3153	acetyltransferase
HV229_RS22440	COG3154	lipid carrier protein
HV229_RS22445	COG0826	peptidase U32
HV229_RS22450	COG0826	peptidase U32
HV229_RS22455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV229_RS22460	COG0814	amino acid
HV229_RS22465	COG0513	Belongs to the DEAD box helicase family
HV229_RS22495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV229_RS22505	COG0195	Participates in both transcription termination and antitermination
HV229_RS22530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV229_RS22535	COG0583	DNA-binding transcription factor activity
HV229_RS22540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV229_RS22545	COG3069	C4-dicarboxylate transmembrane transporter activity
HV229_RS22555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV229_RS22560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV229_RS22570	COG1534	Rna-binding protein
HV229_RS22580	COG2027	D-alanyl-D-alanine carboxypeptidase
HV229_RS22590	COG0697	spore germination
HV229_RS22595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV229_RS22600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV229_RS22605	COG0142	geranyltranstransferase activity
HV229_RS22610	COG3423	Transcriptional regulator
HV229_RS22620	COG5007	Belongs to the BolA IbaG family
HV229_RS22625	COG3113	response to antibiotic
HV229_RS22630	COG2854	intermembrane phospholipid transfer
HV229_RS22635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV229_RS22640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV229_RS22645	COG1127	ABC transporter
HV229_RS22650	COG0530	calcium, potassium:sodium antiporter activity
HV229_RS22655	COG0517	IMP dehydrogenase activity
HV229_RS22655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV229_RS22660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV229_RS22665	COG3117	lipopolysaccharide transmembrane transporter activity
HV229_RS22670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV229_RS22675	COG1137	ATPase activity
HV229_RS22685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV229_RS22700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS22710	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV229_RS22715	COG0784	Response regulator, receiver
HV229_RS22715	COG5002	protein histidine kinase activity
HV229_RS22715	COG2198	Histidine kinase
HV229_RS22720	COG1242	4 iron, 4 sulfur cluster binding
HV229_RS22725	COG0070	glutamate synthase
HV229_RS22725	COG0069	glutamate synthase activity
HV229_RS22725	COG0067	glutamate synthase
HV229_RS22730	COG0493	'glutamate synthase
HV229_RS22735	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV229_RS22740	COG0402	S-adenosylhomocysteine deaminase activity
HV229_RS22745	COG2731	YhcH YjgK YiaL family protein
HV229_RS22775	COG3069	C4-dicarboxylate transmembrane transporter activity
HV229_RS22780	COG2969	positive regulation of protein catabolic process
HV229_RS22785	COG0625	glutathione transferase activity
HV229_RS22800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV229_RS22805	COG3105	Protein conserved in bacteria
HV229_RS22810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV229_RS22815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV229_RS22835	COG2732	(Barnase) inhibitor
HV229_RS22855	COG0583	DNA-binding transcription factor activity
HV229_RS22860	COG0312	modulator of DNA gyrase
HV229_RS22865	COG3164	Protein of unknown function
HV229_RS22870	COG1530	ribonuclease E activity
HV229_RS22880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV229_RS22885	COG1792	Involved in formation and maintenance of cell shape
HV229_RS22890	COG1077	Cell shape determining protein MreB Mrl
HV229_RS22895	COG2199	diguanylate cyclase activity
HV229_RS22895	COG2200	EAL domain
HV229_RS22900	COG0604	alcohol dehydrogenase
HV229_RS22915	COG0511	ligase activity, forming carbon-carbon bonds
HV229_RS22920	COG0439	Biotin carboxylase
HV229_RS22925	COG3924	membrane
HV229_RS22930	COG4145	pantothenate transmembrane transporter activity
HV229_RS22955	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV229_RS22965	COG1309	transcriptional regulator
HV229_RS22970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV229_RS22975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV229_RS22985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV229_RS22990	COG4597	amino acid ABC transporter
HV229_RS22995	COG0765	amino acid transport
HV229_RS23000	COG1126	abc transporter atp-binding protein
HV229_RS23035	COG3290	protein histidine kinase activity
HV229_RS23040	COG4565	transcriptional regulatory protein
HV229_RS23050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV229_RS23055	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS23055	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV229_RS23060	COG3647	Membrane
HV229_RS23070	COG2211	Major facilitator Superfamily
HV229_RS23075	COG1486	melibiose metabolic process
HV229_RS23080	COG2169	Transcriptional regulator
HV229_RS23085	COG1982	Orn Lys Arg decarboxylase major
HV229_RS23090	COG2207	Transcriptional regulator
HV229_RS23095	COG0531	amino acid
HV229_RS23140	COG2824	Alkylphosphonate utilization operon protein PhnA
HV229_RS23145	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV229_RS23150	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV229_RS23160	COG3639	organic phosphonate transmembrane transporter activity
HV229_RS23165	COG2188	Transcriptional regulator
HV229_RS23170	COG3624	Phosphonate C-P lyase system protein PhnG
HV229_RS23175	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV229_RS23180	COG3626	phosphonate metabolism
HV229_RS23185	COG3627	carbon phosphorus lyase activity
HV229_RS23190	COG4107	phosphonate C-P lyase system protein PhnK
HV229_RS23195	COG4778	phosphonate C-P lyase system protein PhnL
HV229_RS23200	COG3454	Phosphonate metabolism
HV229_RS23205	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV229_RS23210	COG0456	acetyltransferase
HV229_RS23215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV229_RS23230	COG1129	ABC transporter
HV229_RS23235	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS23260	COG0745	RESPONSE REGULATOR receiver
HV229_RS23270	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV229_RS23275	COG1301	dicarboxylic acid transport
HV229_RS23280	COG4235	cytochrome complex assembly
HV229_RS23285	COG3088	subunit of a heme lyase
HV229_RS23290	COG1138	Cytochrome C-type biogenesis protein
HV229_RS23295	COG3301	Polysulphide reductase, NrfD
HV229_RS23300	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS23305	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV229_RS23320	COG3162	membrane
HV229_RS23330	COG1346	cytolysis
HV229_RS23335	COG1380	Effector of murein hydrolase LrgA
HV229_RS23340	COG0583	DNA-binding transcription factor activity
HV229_RS23345	COG0025	NhaP-type Na H and K H
HV229_RS23350	COG2252	PERMEase
HV229_RS23355	COG0789	Transcriptional regulator
HV229_RS23365	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV229_RS23375	COG0629	single-stranded DNA binding
HV229_RS23380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV229_RS23385	COG2315	Protein conserved in bacteria
HV229_RS23390	COG3700	Belongs to the class B bacterial acid phosphatase family
HV229_RS23395	COG1448	Aminotransferase
HV229_RS23405	COG0305	Participates in initiation and elongation during chromosome replication
HV229_RS23420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV229_RS23430	COG0735	belongs to the Fur family
HV229_RS23435	COG3237	CsbD-like
HV229_RS23440	COG0534	Mate efflux family protein
HV229_RS23450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV229_RS23465	COG3121	Chaperone
HV229_RS23470	COG3188	usher protein
HV229_RS23475	COG3539	Fimbrial protein
HV229_RS23505	COG2182	Extracellular solute-binding protein
HV229_RS23520	COG3223	Belongs to the PsiE family
HV229_RS23525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV229_RS23530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV229_RS23555	COG0527	aspartate kinase activity
HV229_RS23570	COG1187	pseudouridine synthase activity
HV229_RS23575	COG4977	sequence-specific DNA binding
HV229_RS23595	COG1410	methionine synthase
HV229_RS23595	COG0646	methionine synthase
HV229_RS23615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV229_RS23645	COG0151	Belongs to the GarS family
HV229_RS23655	COG4191	Histidine kinase
HV229_RS23710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV229_RS23715	COG2104	thiamine diphosphate biosynthetic process
HV229_RS23730	COG1278	Cold shock
HV229_RS23740	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV229_RS23775	COG0250	Participates in transcription elongation, termination and antitermination
HV229_RS23820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV229_RS23880	COG0583	DNA-binding transcription factor activity
HV229_RS23885	COG3979	chitinase
HV229_RS23920	COG2207	Transcriptional regulator
HV229_RS23925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS23930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV229_RS23935	COG1882	Formate acetyltransferase
HV229_RS23940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS23945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS23950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV229_RS23950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS23950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS23960	COG0371	Dehydrogenase
HV229_RS23970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV229_RS23975	COG0583	DNA-binding transcription factor activity
HV229_RS23985	COG0737	Belongs to the 5'-nucleotidase family
HV229_RS23995	COG0460	homoserine dehydrogenase
HV229_RS23995	COG0527	aspartate kinase activity
HV229_RS24000	COG0626	cystathionine gamma-synthase activity
HV229_RS24010	COG2211	Major facilitator Superfamily
HV229_RS24025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV229_RS24030	COG1609	Transcriptional regulator
HV229_RS24035	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV229_RS24050	COG1575	Belongs to the MenA family. Type 1 subfamily
HV229_RS24070	COG3074	FtsZ-dependent cytokinesis
HV229_RS24075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV229_RS24085	COG1494	fructose-1,6-bisphosphatase
HV229_RS24095	COG3152	Membrane
HV229_RS24120	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV229_RS24135	COG3678	ATP-independent chaperone mediated protein folding
HV229_RS24140	COG0745	RESPONSE REGULATOR receiver
HV229_RS24145	COG2205	protein histidine kinase activity
HV229_RS24150	COG2271	Major facilitator Superfamily
HV229_RS24155	COG1082	Xylose isomerase domain protein TIM barrel
HV229_RS24160	COG2188	Transcriptional regulator
HV229_RS24165	COG2258	MOSC domain
HV229_RS24170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV229_RS24215	COG1454	alcohol dehydrogenase
HV229_RS24235	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV229_RS24245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS24250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS24250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV229_RS24255	COG1363	Peptidase, m42
HV229_RS24260	COG3711	transcriptional antiterminator
HV229_RS24260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV229_RS24280	COG0437	4 iron, 4 sulfur cluster binding
HV229_RS24285	COG2864	formate dehydrogenase
HV229_RS24300	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HV229_RS24310	COG4680	protein conserved in bacteria
HV229_RS24315	COG5499	transcription regulator containing HTH domain
HV229_RS24320	COG0456	acetyltransferase
HV229_RS24335	COG1011	Hydrolase
HV229_RS24345	COG0477	Major facilitator Superfamily
HV229_RS24355	COG1063	alcohol dehydrogenase
HV229_RS24360	COG3684	Belongs to the aldolase LacD family
HV229_RS24365	COG2084	Dehydrogenase
HV229_RS24370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS24375	COG1349	DNA-binding transcription factor activity
HV229_RS24390	COG3852	Histidine kinase
HV229_RS24395	COG2204	response regulator
HV229_RS24405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV229_RS24430	COG0204	Acyl-transferase
HV229_RS24445	COG3084	Protein conserved in bacteria
HV229_RS24450	COG0746	molybdenum cofactor guanylyltransferase activity
HV229_RS24455	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV229_RS24495	COG1739	Uncharacterized protein family UPF0029
HV229_RS24515	COG1609	Transcriptional regulator
HV229_RS24520	COG1940	carbohydrate kinase activity
HV229_RS24530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV229_RS24545	COG0805	protein transport
HV229_RS24590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV229_RS24595	COG0583	DNA-binding transcription factor activity
HV229_RS24600	COG0697	spore germination
HV229_RS24605	COG0561	phosphatase activity
HV229_RS24610	COG2267	carboxylic ester hydrolase activity
HV229_RS24615	COG1280	lysine exporter protein (LysE YggA)
HV229_RS24620	COG1280	lysine exporter protein (LysE YggA)
HV229_RS24655	COG1011	Hydrolase
HV229_RS24700	COG2959	enzyme of heme biosynthesis
HV229_RS24705	COG3071	HemY protein
HV229_RS24750	COG2244	polysaccharide biosynthetic process
HV229_RS24755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV229_RS24760	COG0456	acetyltransferase
HV229_RS24765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV229_RS24770	COG1088	dTDP-glucose 4,6-dehydratase activity
HV229_RS24775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV229_RS24790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV229_RS24795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV229_RS24805	COG3118	belongs to the thioredoxin family
HV229_RS24825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV229_RS24845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV229_RS24855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV229_RS24860	COG3978	acetolactate synthase activity
HV229_RS24880	COG3085	chromosome segregation
HV229_RS24920	COG2186	Transcriptional regulator
HV229_RS24925	COG0477	Major facilitator Superfamily
HV229_RS24930	COG1609	Transcriptional regulator
HV229_RS24935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV229_RS24940	COG1879	ABC-type sugar transport system periplasmic component
HV229_RS24945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV229_RS24955	COG1869	D-ribose catabolic process
HV229_RS24980	COG1522	sequence-specific DNA binding
HV229_RS24985	COG0716	FMN binding
HV229_RS25000	COG3312	ion transport
HV229_RS25025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV229_RS25035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV229_RS25040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV229_RS25050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV229_RS25055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV229_RS25060	COG0573	inorganic phosphate transmembrane transporter activity
HV229_RS25065	COG0581	inorganic phosphate transmembrane transporter activity
HV229_RS25075	COG0704	Plays a role in the regulation of phosphate uptake
HV229_RS25080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV229_RS25085	COG2252	PERMEase
HV229_RS25090	COG0431	NADPH-dependent FMN reductase
HV229_RS25095	COG2091	lysine biosynthetic process via aminoadipic acid
HV229_RS25130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV229_RS25190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HV229_RS25220	COG1278	Cold shock
HV229_RS25270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV229_RS25285	COG1702	phosphate starvation-inducible protein PhoH
HV229_RS25400	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV229_RS25430	COG3941	tape measure
HV229_RS25525	COG1475	DNA binding
HV229_RS25530	COG1475	DNA binding
HV229_RS25535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV229_RS25665	COG2433	Pfam Transposase IS66
HV229_RS25670	COG3436	PFAM IS66 Orf2 family protein
HV229_RS25690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV229_RS25710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV229_RS25745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV229_RS25750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV229_RS25815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV229_RS25865	COG1724	mRNA binding
HV229_RS25940	COG4626	Terminase
HV229_RS25940	COG1802	Transcriptional regulator
HV229_RS25955	COG0616	signal peptide processing
HV229_RS26030	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV229_RS26040	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1