locus-tag	class	description
HV345_RS00010	COG0592	DNA-directed DNA polymerase activity
HV345_RS00025	COG0561	phosphatase activity
HV345_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV345_RS00040	COG5645	(Lipo)protein
HV345_RS00070	COG2149	membrane
HV345_RS00080	COG0641	radical SAM
HV345_RS00090	COG2610	gluconate transmembrane transporter activity
HV345_RS00095	COG0583	DNA-binding transcription factor activity
HV345_RS00105	COG2814	Major facilitator Superfamily
HV345_RS00125	COG0028	Belongs to the TPP enzyme family
HV345_RS00130	COG0440	acetolactate synthase activity
HV345_RS00135	COG1349	DNA-binding transcription factor activity
HV345_RS00145	COG0738	Major facilitator superfamily
HV345_RS00155	COG2197	response regulator
HV345_RS00185	COG3620	sequence-specific DNA binding
HV345_RS00195	COG2723	6-phospho-beta-galactosidase activity
HV345_RS00210	COG1464	Belongs to the NlpA lipoprotein family
HV345_RS00215	COG0697	spore germination
HV345_RS00225	COG0604	alcohol dehydrogenase
HV345_RS00230	COG0583	DNA-binding transcription factor activity
HV345_RS00250	COG2771	luxR family
HV345_RS00265	COG3468	outer membrane autotransporter barrel domain protein
HV345_RS00265	COG3210	domain, Protein
HV345_RS00315	COG2211	Major facilitator Superfamily
HV345_RS00320	COG1501	Belongs to the glycosyl hydrolase 31 family
HV345_RS00325	COG3711	transcriptional antiterminator
HV345_RS00330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS00330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS00330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS00335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS00340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS00340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS00350	COG0191	fructose-bisphosphate aldolase activity
HV345_RS00360	COG2982	Protein involved in outer membrane biogenesis
HV345_RS00365	COG2233	PERMEase
HV345_RS00370	COG0786	glutamate:sodium symporter activity
HV345_RS00375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV345_RS00380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV345_RS00385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV345_RS00405	COG2860	membrane
HV345_RS00455	COG0582	viral genome integration into host DNA
HV345_RS00460	COG1561	YicC-like family, N-terminal region
HV345_RS00485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV345_RS00500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV345_RS00515	COG1519	Transferase
HV345_RS00520	COG0859	PFAM glycosyl transferase family 9
HV345_RS00525	COG0438	transferase activity, transferring glycosyl groups
HV345_RS00530	COG0515	serine threonine protein kinase
HV345_RS00555	COG0859	PFAM glycosyl transferase family 9
HV345_RS00560	COG0859	PFAM glycosyl transferase family 9
HV345_RS00575	COG0156	8-amino-7-oxononanoate synthase activity
HV345_RS00590	COG1216	Glycosyl transferase, family 2
HV345_RS00595	COG2861	carbohydrate metabolic process
HV345_RS00600	COG4942	peptidase
HV345_RS00610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV345_RS00615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV345_RS00635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV345_RS00640	COG2271	Major facilitator Superfamily
HV345_RS00650	COG2186	Transcriptional regulator
HV345_RS00670	COG3722	fumarate hydratase activity
HV345_RS00680	COG2213	PTS system mannitol-specific
HV345_RS00680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS00690	COG1566	PFAM secretion protein HlyD family protein
HV345_RS00695	COG0625	glutathione transferase activity
HV345_RS00705	COG3276	selenocysteine insertion sequence binding
HV345_RS00710	COG1454	alcohol dehydrogenase
HV345_RS00715	COG1012	belongs to the aldehyde dehydrogenase family
HV345_RS00725	COG1566	PFAM secretion protein HlyD family protein
HV345_RS00730	COG0583	DNA-binding transcription factor activity
HV345_RS00735	COG3713	MltA-interacting MipA family protein
HV345_RS00745	COG0235	Class ii aldolase
HV345_RS00750	COG3623	hexulose-6-phosphate isomerase
HV345_RS00755	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV345_RS00760	COG1070	Carbohydrate kinase
HV345_RS00765	COG2271	Major facilitator Superfamily
HV345_RS00775	COG2731	YhcH YjgK YiaL family protein
HV345_RS00785	COG1414	Transcriptional regulator
HV345_RS00790	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV345_RS00795	COG3977	Valine--pyruvate aminotransferase
HV345_RS00800	COG0366	Alpha amylase catalytic
HV345_RS00805	COG2992	FlgJ-related protein
HV345_RS00810	COG1609	Transcriptional regulator
HV345_RS00810	COG2207	Transcriptional regulator
HV345_RS00815	COG4214	carbohydrate transport
HV345_RS00825	COG4213	ABC transporter substrate-binding protein
HV345_RS00835	COG1070	Carbohydrate kinase
HV345_RS00840	COG4682	membrane
HV345_RS00850	COG3274	enterobacterial common antigen metabolic process
HV345_RS00875	COG1278	Cold shock
HV345_RS00880	COG2944	sequence-specific DNA binding
HV345_RS00895	COG2814	Major facilitator Superfamily
HV345_RS00900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS00910	COG1609	Transcriptional regulator
HV345_RS00915	COG2885	chlorophyll binding
HV345_RS00920	COG0243	molybdopterin cofactor binding
HV345_RS00925	COG0456	acetyltransferase
HV345_RS00930	COG2818	Glycosylase
HV345_RS00935	COG5571	outer membrane autotransporter
HV345_RS00940	COG2223	nitrite transmembrane transporter activity
HV345_RS00960	COG0747	negative chemotaxis
HV345_RS00965	COG0601	transmembrane transport
HV345_RS00970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV345_RS00975	COG0444	Belongs to the ABC transporter superfamily
HV345_RS00980	COG4608	Belongs to the ABC transporter superfamily
HV345_RS00985	COG2204	response regulator
HV345_RS00990	COG0814	amino acid
HV345_RS01005	COG2199	diguanylate cyclase activity
HV345_RS01005	COG2200	EAL domain
HV345_RS01020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS01025	COG2200	EAL domain
HV345_RS01030	COG2982	Protein involved in outer membrane biogenesis
HV345_RS01035	COG0477	Major facilitator Superfamily
HV345_RS01040	COG1295	ribonuclease BN
HV345_RS01045	COG0583	DNA-binding transcription factor activity
HV345_RS01055	COG2197	response regulator
HV345_RS01065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV345_RS01080	COG1858	cytochrome C peroxidase
HV345_RS01090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV345_RS01095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV345_RS01100	COG0339	signal peptide processing
HV345_RS01115	COG1959	2 iron, 2 sulfur cluster binding
HV345_RS01125	COG0589	response to stress
HV345_RS01135	COG0306	phosphate transporter
HV345_RS01140	COG2081	HI0933 family
HV345_RS01145	COG2239	Acts as a magnesium transporter
HV345_RS01150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV345_RS01155	COG0842	Transport permease protein
HV345_RS01155	COG1129	ABC transporter
HV345_RS01160	COG0842	Transport permease protein
HV345_RS01175	COG3479	Phenolic acid decarboxylase
HV345_RS01180	COG2091	lysine biosynthetic process via aminoadipic acid
HV345_RS01185	COG0628	permease
HV345_RS01190	COG0477	Major facilitator Superfamily
HV345_RS01200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV345_RS01215	COG3714	YhhN family
HV345_RS01225	COG3776	membrane
HV345_RS01230	COG0742	ribosomal rna small subunit methyltransferase
HV345_RS01235	COG0552	protein localization to endoplasmic reticulum
HV345_RS01240	COG2884	Cell division ATP-binding protein ftsE
HV345_RS01245	COG2177	Part of the ABC transporter FtsEX involved in
HV345_RS01255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV345_RS01260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV345_RS01285	COG0683	leucine binding
HV345_RS01295	COG0683	leucine binding
HV345_RS01305	COG4177	L-phenylalanine transmembrane transporter activity
HV345_RS01310	COG0411	ABC transporter
HV345_RS01315	COG0410	ABC transporter
HV345_RS01345	COG0584	glycerophosphoryl diester phosphodiesterase
HV345_RS01355	COG0405	Gamma-glutamyltransferase
HV345_RS01365	COG1247	-acetyltransferase
HV345_RS01370	COG0673	inositol 2-dehydrogenase activity
HV345_RS01375	COG1741	Belongs to the pirin family
HV345_RS01380	COG1609	Transcriptional regulator
HV345_RS01385	COG3265	gluconokinase activity
HV345_RS01390	COG2610	gluconate transmembrane transporter activity
HV345_RS01395	COG2095	MarC family integral membrane protein
HV345_RS01400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV345_RS01425	COG0058	SHG alpha-glucan phosphorylase activity
HV345_RS01430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV345_RS01445	COG1349	DNA-binding transcription factor activity
HV345_RS01455	COG0058	SHG alpha-glucan phosphorylase activity
HV345_RS01460	COG1640	4-alpha-glucanotransferase
HV345_RS01465	COG2610	gluconate transmembrane transporter activity
HV345_RS01475	COG1040	competence protein
HV345_RS01485	COG5464	transposase or invertase
HV345_RS01500	COG1918	ferrous iron import across plasma membrane
HV345_RS01505	COG2183	response to ionizing radiation
HV345_RS01510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV345_RS01515	COG0745	RESPONSE REGULATOR receiver
HV345_RS01530	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV345_RS01540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV345_RS01545	COG1011	Hydrolase
HV345_RS01555	COG0494	nUDIX hydrolase
HV345_RS01560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV345_RS01565	COG4972	Pilus assembly protein
HV345_RS01585	COG4796	Type ii and iii secretion system protein
HV345_RS01600	COG3266	domain, Protein
HV345_RS01605	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV345_RS01610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV345_RS01620	COG0180	Tryptophanyl-tRNA synthetase
HV345_RS01645	COG2146	nitrite reductase [NAD(P)H] activity
HV345_RS01650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV345_RS01675	COG0512	Glutamine amidotransferase of anthranilate synthase
HV345_RS01685	COG1289	transmembrane transporter activity
HV345_RS01695	COG1765	OsmC-like protein
HV345_RS01700	COG3954	Phosphoribulokinase
HV345_RS01710	COG0429	hydrolase of the alpha beta-hydrolase fold
HV345_RS01715	COG0488	(ABC) transporter
HV345_RS01730	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV345_RS01735	COG1047	Peptidyl-prolyl cis-trans
HV345_RS01745	COG0545	Peptidyl-prolyl cis-trans isomerase
HV345_RS01750	COG2964	Protein conserved in bacteria
HV345_RS01810	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HV345_RS01815	COG3156	type II secretion system protein K
HV345_RS01820	COG4795	General secretion pathway protein
HV345_RS01825	COG2165	general secretion pathway protein
HV345_RS01830	COG2165	general secretion pathway protein
HV345_RS01835	COG2165	general secretion pathway protein
HV345_RS01840	COG1459	type II secretion system
HV345_RS01845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV345_RS01850	COG1450	Type ii and iii secretion system protein
HV345_RS01870	COG0051	transcription antitermination factor activity, RNA binding
HV345_RS01880	COG0088	Forms part of the polypeptide exit tunnel
HV345_RS01895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV345_RS01970	COG0200	Binds to the 23S rRNA
HV345_RS01975	COG0201	protein transport
HV345_RS01990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV345_RS02015	COG0789	Transcriptional regulator
HV345_RS02020	COG3036	rescue of stalled ribosome
HV345_RS02030	COG0569	domain protein
HV345_RS02050	COG0758	DNA mediated transformation
HV345_RS02060	COG0551	DNA topoisomerase type I activity
HV345_RS02080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV345_RS02120	COG1126	abc transporter atp-binding protein
HV345_RS02125	COG0765	amino acid transport
HV345_RS02130	COG4597	amino acid ABC transporter
HV345_RS02135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV345_RS02145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV345_RS02150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV345_RS02155	COG3039	Transposase
HV345_RS02170	COG3561	AntA/AntB antirepressor
HV345_RS02255	COG4626	Terminase
HV345_RS02255	COG1802	Transcriptional regulator
HV345_RS02280	COG4145	pantothenate transmembrane transporter activity
HV345_RS02285	COG3924	membrane
HV345_RS02290	COG0439	Biotin carboxylase
HV345_RS02295	COG0511	ligase activity, forming carbon-carbon bonds
HV345_RS02310	COG0604	alcohol dehydrogenase
HV345_RS02315	COG2199	diguanylate cyclase activity
HV345_RS02315	COG2200	EAL domain
HV345_RS02320	COG1077	Cell shape determining protein MreB Mrl
HV345_RS02325	COG1792	Involved in formation and maintenance of cell shape
HV345_RS02330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV345_RS02340	COG1530	ribonuclease E activity
HV345_RS02345	COG3164	Protein of unknown function
HV345_RS02350	COG0312	modulator of DNA gyrase
HV345_RS02355	COG0583	DNA-binding transcription factor activity
HV345_RS02375	COG2732	(Barnase) inhibitor
HV345_RS02395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV345_RS02400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV345_RS02405	COG3105	Protein conserved in bacteria
HV345_RS02410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV345_RS02425	COG0625	glutathione transferase activity
HV345_RS02430	COG2969	positive regulation of protein catabolic process
HV345_RS02435	COG3069	C4-dicarboxylate transmembrane transporter activity
HV345_RS02465	COG2731	YhcH YjgK YiaL family protein
HV345_RS02470	COG0402	S-adenosylhomocysteine deaminase activity
HV345_RS02475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV345_RS02480	COG0493	'glutamate synthase
HV345_RS02485	COG0069	glutamate synthase activity
HV345_RS02485	COG0070	glutamate synthase
HV345_RS02485	COG0067	glutamate synthase
HV345_RS02490	COG1242	4 iron, 4 sulfur cluster binding
HV345_RS02495	COG0784	Response regulator, receiver
HV345_RS02495	COG2198	Histidine kinase
HV345_RS02495	COG5002	protein histidine kinase activity
HV345_RS02500	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV345_RS02510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS02525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV345_RS02535	COG1137	ATPase activity
HV345_RS02540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV345_RS02545	COG3117	lipopolysaccharide transmembrane transporter activity
HV345_RS02550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV345_RS02555	COG0517	IMP dehydrogenase activity
HV345_RS02555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV345_RS02560	COG0530	calcium, potassium:sodium antiporter activity
HV345_RS02565	COG1127	ABC transporter
HV345_RS02570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV345_RS02575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV345_RS02580	COG2854	intermembrane phospholipid transfer
HV345_RS02585	COG3113	response to antibiotic
HV345_RS02590	COG5007	Belongs to the BolA IbaG family
HV345_RS02600	COG3423	Transcriptional regulator
HV345_RS02605	COG0142	geranyltranstransferase activity
HV345_RS02610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV345_RS02615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV345_RS02620	COG0697	spore germination
HV345_RS02630	COG2027	D-alanyl-D-alanine carboxypeptidase
HV345_RS02640	COG1534	Rna-binding protein
HV345_RS02650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV345_RS02655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV345_RS02665	COG3069	C4-dicarboxylate transmembrane transporter activity
HV345_RS02670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV345_RS02675	COG0583	DNA-binding transcription factor activity
HV345_RS02680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV345_RS02705	COG0195	Participates in both transcription termination and antitermination
HV345_RS02715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV345_RS02745	COG0513	Belongs to the DEAD box helicase family
HV345_RS02750	COG0814	amino acid
HV345_RS02755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV345_RS02760	COG0826	peptidase U32
HV345_RS02765	COG0826	peptidase U32
HV345_RS02770	COG3154	lipid carrier protein
HV345_RS02775	COG3153	acetyltransferase
HV345_RS02790	COG0702	epimerase
HV345_RS02795	COG2823	Periplasmic or secreted lipoprotein
HV345_RS02810	COG3107	peptidoglycan biosynthetic process
HV345_RS02815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV345_RS02820	COG0363	glucosamine-6-phosphate deaminase activity
HV345_RS02825	COG3716	PTS system mannose fructose sorbose family IID component
HV345_RS02830	COG3715	PTS system
HV345_RS02835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS02845	COG2222	sugar isomerase
HV345_RS02850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV345_RS02855	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS02860	COG3716	PTS system mannose fructose sorbose family IID component
HV345_RS02870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS02880	COG1349	DNA-binding transcription factor activity
HV345_RS02885	COG2721	sulfolactate sulfo-lyase activity
HV345_RS02890	COG2271	Major facilitator Superfamily
HV345_RS02900	COG2084	Dehydrogenase
HV345_RS02905	COG1929	Belongs to the glycerate kinase type-1 family
HV345_RS02915	COG0583	DNA-binding transcription factor activity
HV345_RS02935	COG1882	Formate acetyltransferase
HV345_RS02940	COG0251	oxidation-reduction process
HV345_RS02945	COG1760	l-serine dehydratase
HV345_RS02950	COG0814	amino acid
HV345_RS02965	COG1741	Belongs to the pirin family
HV345_RS02970	COG0583	DNA-binding transcription factor activity
HV345_RS02975	COG3152	Membrane
HV345_RS02980	COG0435	Glutathione S-transferase
HV345_RS02985	COG2259	Doxx family
HV345_RS02995	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV345_RS03000	COG4575	ribosome binding
HV345_RS03005	COG1422	Protein of unknown function (DUF1090)
HV345_RS03015	COG0586	Pfam SNARE associated Golgi protein
HV345_RS03020	COG2186	Transcriptional regulator
HV345_RS03025	COG2271	Major facilitator Superfamily
HV345_RS03035	COG2721	sulfolactate sulfo-lyase activity
HV345_RS03055	COG0673	inositol 2-dehydrogenase activity
HV345_RS03060	COG1451	nucleotide metabolic process
HV345_RS03070	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV345_RS03070	COG1902	pentaerythritol trinitrate reductase activity
HV345_RS03085	COG1609	Transcriptional regulator
HV345_RS03095	COG1175	transmembrane transport
HV345_RS03100	COG0395	ABC-type sugar transport system, permease component
HV345_RS03105	COG0366	Alpha amylase catalytic
HV345_RS03110	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HV345_RS03115	COG0531	amino acid
HV345_RS03120	COG2731	YhcH YjgK YiaL family protein
HV345_RS03125	COG3250	beta-galactosidase activity
HV345_RS03130	COG1609	Transcriptional regulator
HV345_RS03135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV345_RS03145	COG0840	transmembrane signaling receptor activity
HV345_RS03150	COG1695	Transcriptional regulator
HV345_RS03155	COG2375	cellular response to nickel ion
HV345_RS03165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV345_RS03270	COG4983	Phage plasmid primase, P4 family domain protein
HV345_RS03310	COG3596	GTP binding
HV345_RS03350	COG2378	regulation of single-species biofilm formation
HV345_RS03365	COG4372	Transposase
HV345_RS03370	COG3436	PFAM IS66 Orf2 family protein
HV345_RS03410	COG2003	Belongs to the UPF0758 family
HV345_RS03430	COG0582	viral genome integration into host DNA
HV345_RS03520	COG4695	Portal protein
HV345_RS03630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV345_RS03690	COG0358	DNA primase activity
HV345_RS03695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV345_RS03700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV345_RS03705	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV345_RS03715	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV345_RS03740	COG0471	metal ion transport
HV345_RS03745	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS03750	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS03765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV345_RS03780	COG4991	sh3 domain protein
HV345_RS03785	COG3025	triphosphatase activity
HV345_RS03840	COG3384	dioxygenase
HV345_RS03845	COG0754	glutathionylspermidine amidase activity
HV345_RS03860	COG0494	nUDIX hydrolase
HV345_RS03865	COG3151	Protein conserved in bacteria
HV345_RS03870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV345_RS03875	COG3150	esterase
HV345_RS03880	COG0187	DNA topoisomerase II activity
HV345_RS03885	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV345_RS03890	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV345_RS03905	COG3111	PFAM Bacterial OB fold (BOF) protein
HV345_RS03925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV345_RS03935	COG0656	L-ascorbic acid biosynthetic process
HV345_RS03940	COG1979	alcohol dehydrogenase
HV345_RS03945	COG2207	Transcriptional regulator
HV345_RS03950	COG0586	Pfam SNARE associated Golgi protein
HV345_RS03955	COG0626	cystathionine gamma-synthase activity
HV345_RS03965	COG0848	biopolymer transport protein
HV345_RS03985	COG0667	Aldo Keto reductase
HV345_RS03995	COG0840	transmembrane signaling receptor activity
HV345_RS04005	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV345_RS04010	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS04015	COG5557	Pfam Polysulphide reductase, NrfD
HV345_RS04020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV345_RS04025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV345_RS04030	COG1773	rubredoxin
HV345_RS04040	COG0298	carbon dioxide binding
HV345_RS04045	COG0625	glutathione transferase activity
HV345_RS04050	COG0243	molybdopterin cofactor binding
HV345_RS04055	COG0754	glutathionylspermidine amidase activity
HV345_RS04075	COG1846	Transcriptional regulator
HV345_RS04180	COG0412	Dienelactone hydrolase
HV345_RS04195	COG1811	Na channel or pump
HV345_RS04200	COG1982	Orn Lys Arg decarboxylase major
HV345_RS04205	COG2211	Major facilitator Superfamily
HV345_RS04220	COG1194	a g-specific adenine glycosylase
HV345_RS04230	COG3171	Protein conserved in bacteria
HV345_RS04240	COG0252	asparaginase activity
HV345_RS04250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HV345_RS04255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV345_RS04260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV345_RS04275	COG0762	integral membrane protein
HV345_RS04280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV345_RS04285	COG2805	Type II/IV secretion system protein
HV345_RS04300	COG0189	ligase activity
HV345_RS04305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV345_RS04310	COG2356	endonuclease I
HV345_RS04315	COG3091	SprT-like family
HV345_RS04320	COG2814	Major facilitator Superfamily
HV345_RS04340	COG1166	arginine decarboxylase activity
HV345_RS04350	COG0501	Belongs to the peptidase M48B family
HV345_RS04355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV345_RS04360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS04365	COG2213	PTS system mannitol-specific
HV345_RS04370	COG1063	alcohol dehydrogenase
HV345_RS04375	COG1494	fructose-1,6-bisphosphatase
HV345_RS04385	COG1072	(Pantothenic acid kinase))
HV345_RS04400	COG0191	fructose-bisphosphate aldolase activity
HV345_RS04405	COG0549	Belongs to the carbamate kinase family
HV345_RS04410	COG2271	Major facilitator Superfamily
HV345_RS04415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV345_RS04420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV345_RS04430	COG0583	DNA-binding transcription factor activity
HV345_RS04435	COG0668	transmembrane transport
HV345_RS04445	COG1279	arginine transmembrane transporter activity
HV345_RS04450	COG2968	Membrane
HV345_RS04455	COG0583	DNA-binding transcription factor activity
HV345_RS04460	COG0427	acetyl-CoA hydrolase
HV345_RS04465	COG1024	Enoyl-CoA hydratase
HV345_RS04470	COG1703	isobutyryl-CoA mutase activity
HV345_RS04475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV345_RS04475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV345_RS04490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV345_RS04495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV345_RS04515	COG0006	proline dipeptidase activity
HV345_RS04520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV345_RS04525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV345_RS04545	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS04550	COG2723	6-phospho-beta-galactosidase activity
HV345_RS04555	COG1737	Transcriptional regulator
HV345_RS04565	COG1272	protein, Hemolysin III
HV345_RS04575	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV345_RS04600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV345_RS04620	COG4942	peptidase
HV345_RS04635	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV345_RS04640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV345_RS04645	COG0457	Tetratricopeptide repeat
HV345_RS04650	COG0438	transferase activity, transferring glycosyl groups
HV345_RS04655	COG1596	polysaccharide export
HV345_RS04660	COG1682	transport, permease protein
HV345_RS04665	COG1134	teichoic acid transport
HV345_RS04670	COG3524	carbohydrate:proton symporter activity
HV345_RS04675	COG4783	chaperone-mediated protein folding
HV345_RS04675	COG1560	Kdo2-lipid A biosynthetic process
HV345_RS04685	COG0457	Tetratricopeptide repeat
HV345_RS04690	COG0726	polysaccharide deacetylase
HV345_RS04690	COG1649	PFAM Uncharacterised BCR, COG1649
HV345_RS04695	COG1215	transferase activity, transferring glycosyl groups
HV345_RS04705	COG3592	Divergent 4Fe-4S mono-cluster
HV345_RS04710	COG2388	GCN5-related N-acetyl-transferase
HV345_RS04715	COG0583	DNA-binding transcription factor activity
HV345_RS04720	COG0666	response to abiotic stimulus
HV345_RS04730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV345_RS04735	COG1304	FMN binding
HV345_RS04745	COG0549	Belongs to the carbamate kinase family
HV345_RS04750	COG0402	S-adenosylhomocysteine deaminase activity
HV345_RS04765	COG0814	amino acid
HV345_RS04780	COG0183	Belongs to the thiolase family
HV345_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS04800	COG1794	racemase activity, acting on amino acids and derivatives
HV345_RS04805	COG0583	DNA-binding transcription factor activity
HV345_RS04815	COG1609	Transcriptional regulator
HV345_RS04835	COG0667	Aldo Keto reductase
HV345_RS04845	COG0861	Integral membrane protein TerC family
HV345_RS04875	COG2165	general secretion pathway protein
HV345_RS04880	COG4795	General secretion pathway protein
HV345_RS04890	COG4967	type IV pilus modification protein PilV
HV345_RS04895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV345_RS04905	COG1074	ATP-dependent DNA helicase activity
HV345_RS04910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV345_RS04915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV345_RS04915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV345_RS04920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV345_RS04935	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV345_RS04940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV345_RS04945	COG2166	iron-sulfur cluster assembly
HV345_RS04950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV345_RS04960	COG0583	DNA-binding transcription factor activity
HV345_RS04965	COG2363	Small membrane protein
HV345_RS04975	COG1349	DNA-binding transcription factor activity
HV345_RS05000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV345_RS05020	COG0235	Class ii aldolase
HV345_RS05025	COG1454	alcohol dehydrogenase
HV345_RS05035	COG1760	l-serine dehydratase
HV345_RS05040	COG0814	amino acid
HV345_RS05045	COG1611	Belongs to the LOG family
HV345_RS05060	COG3098	single-species biofilm formation
HV345_RS05065	COG0564	pseudouridine synthase activity
HV345_RS05070	COG0716	FMN binding
HV345_RS05075	COG2271	Major facilitator Superfamily
HV345_RS05080	COG4948	Mandelate Racemase Muconate Lactonizing
HV345_RS05085	COG4948	Mandelate Racemase Muconate Lactonizing
HV345_RS05090	COG1929	Belongs to the glycerate kinase type-1 family
HV345_RS05095	COG3850	Histidine kinase
HV345_RS05095	COG3437	response regulator, receiver
HV345_RS05095	COG4999	Histidine kinase
HV345_RS05095	COG2205	protein histidine kinase activity
HV345_RS05105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV345_RS05110	COG3956	TIGRFAM MazG family protein
HV345_RS05160	COG3121	Chaperone
HV345_RS05180	COG0602	queuosine metabolic process
HV345_RS05190	COG0720	synthase
HV345_RS05210	COG2234	aminopeptidase activity
HV345_RS05265	COG1388	LysM domain
HV345_RS05265	COG4942	peptidase
HV345_RS05295	COG2200	EAL domain
HV345_RS05300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV345_RS05305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV345_RS05310	COG1121	(ABC) transporter
HV345_RS05330	COG0309	Hydrogenase expression formation protein (HypE)
HV345_RS05335	COG0409	Hydrogenase expression formation protein
HV345_RS05340	COG0298	carbon dioxide binding
HV345_RS05345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV345_RS05360	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV345_RS05365	COG0651	ATP synthesis coupled electron transport
HV345_RS05370	COG0650	Formate hydrogenlyase subunit 4
HV345_RS05375	COG3261	NADH dehydrogenase
HV345_RS05375	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV345_RS05380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV345_RS05385	COG3260	NADH ubiquinone oxidoreductase 20
HV345_RS05395	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV345_RS05410	COG2723	6-phospho-beta-galactosidase activity
HV345_RS05415	COG1263	PTS System
HV345_RS05415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS05420	COG1609	Transcriptional regulator
HV345_RS05425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV345_RS05430	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV345_RS05450	COG0517	IMP dehydrogenase activity
HV345_RS05450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV345_RS05455	COG1349	DNA-binding transcription factor activity
HV345_RS05460	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS05475	COG3732	PTS system glucitol sorbitol-specific
HV345_RS05480	COG3730	PTS system glucitol sorbitol-specific
HV345_RS05485	COG2951	lytic endotransglycosylase activity
HV345_RS05490	COG1546	Belongs to the CinA family
HV345_RS05510	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV345_RS05540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV345_RS05545	COG1238	metal cluster binding
HV345_RS05560	COG2814	Major facilitator Superfamily
HV345_RS05565	COG1566	PFAM secretion protein HlyD family protein
HV345_RS05570	COG1846	Transcriptional regulator
HV345_RS05580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV345_RS05585	COG2814	Major facilitator Superfamily
HV345_RS05595	COG4176	ABC-type proline glycine betaine transport system permease component
HV345_RS05610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV345_RS05625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV345_RS05655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV345_RS05660	COG0640	Transcriptional regulator
HV345_RS05665	COG0401	homolog of Blt101
HV345_RS05670	COG1652	LysM domain
HV345_RS05675	COG1802	Transcriptional regulator
HV345_RS05680	COG1113	amino acid transport
HV345_RS05685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV345_RS05690	COG1012	belongs to the aldehyde dehydrogenase family
HV345_RS05695	COG0579	oxidoreductase
HV345_RS05735	COG0642	Histidine kinase
HV345_RS05745	COG3188	usher protein
HV345_RS05750	COG3121	Chaperone
HV345_RS05760	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS05800	COG0438	transferase activity, transferring glycosyl groups
HV345_RS05805	COG0297	glycogen (starch) synthase activity
HV345_RS05805	COG0438	transferase activity, transferring glycosyl groups
HV345_RS05835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV345_RS05840	COG1757	Na H antiporter
HV345_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS05875	COG2003	Belongs to the UPF0758 family
HV345_RS05895	COG2378	regulation of single-species biofilm formation
HV345_RS05905	COG2378	regulation of single-species biofilm formation
HV345_RS05915	COG3596	GTP binding
HV345_RS05930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV345_RS05935	COG0501	Belongs to the peptidase M48B family
HV345_RS05985	COG0542	response to heat
HV345_RS05990	COG0071	Belongs to the small heat shock protein (HSP20) family
HV345_RS06015	COG3328	transposase activity
HV345_RS06025	COG3039	Transposase
HV345_RS06040	COG1396	sequence-specific DNA binding
HV345_RS06050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV345_RS06055	COG0732	type I restriction modification DNA specificity domain
HV345_RS06060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV345_RS06075	COG4983	Phage plasmid primase, P4 family domain protein
HV345_RS06080	COG3311	Transcriptional regulator
HV345_RS06090	COG0582	viral genome integration into host DNA
HV345_RS06100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV345_RS06125	COG2867	negative regulation of translational initiation
HV345_RS06140	COG0497	DNA recombination
HV345_RS06155	COG4536	flavin adenine dinucleotide binding
HV345_RS06160	COG4137	Cytochrome C assembly protein
HV345_RS06165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV345_RS06190	COG2885	chlorophyll binding
HV345_RS06195	COG2199	diguanylate cyclase activity
HV345_RS06210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV345_RS06215	COG0287	Prephenate dehydrogenase
HV345_RS06215	COG1605	Chorismate mutase
HV345_RS06220	COG1605	Chorismate mutase
HV345_RS06220	COG0077	Prephenate dehydratase
HV345_RS06230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV345_RS06235	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV345_RS06250	COG0542	response to heat
HV345_RS06275	COG0477	Major facilitator Superfamily
HV345_RS06280	COG5544	Lipoprotein
HV345_RS06285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV345_RS06300	COG3118	belongs to the thioredoxin family
HV345_RS06305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV345_RS06320	COG0513	Belongs to the DEAD box helicase family
HV345_RS06330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV345_RS06340	COG1595	DNA-templated transcription, initiation
HV345_RS06350	COG3026	antisigma factor binding
HV345_RS06355	COG3086	response to oxidative stress
HV345_RS06365	COG0681	Belongs to the peptidase S26 family
HV345_RS06385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV345_RS06395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV345_RS06545	COG3179	chitinase
HV345_RS06630	COG4386	tail sheath protein
HV345_RS06645	COG0741	lytic transglycosylase activity
HV345_RS06700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV345_RS06705	COG1737	Transcriptional regulator
HV345_RS06710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV345_RS06715	COG1263	PTS System
HV345_RS06715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS06720	COG0560	Phosphoserine phosphatase
HV345_RS06740	COG2205	protein histidine kinase activity
HV345_RS06745	COG3170	Tfp pilus assembly protein FimV
HV345_RS06750	COG2204	response regulator
HV345_RS06755	COG0347	Belongs to the P(II) protein family
HV345_RS06760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV345_RS06760	COG1017	nitric oxide dioxygenase activity
HV345_RS06790	COG4638	Rieske (2fe-2S)
HV345_RS06795	COG0583	DNA-binding transcription factor activity
HV345_RS06800	COG3539	Fimbrial protein
HV345_RS06805	COG3188	usher protein
HV345_RS06810	COG3121	Chaperone
HV345_RS06815	COG3539	Fimbrial protein
HV345_RS06820	COG2814	Major facilitator Superfamily
HV345_RS06825	COG3711	transcriptional antiterminator
HV345_RS06830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV345_RS06830	COG0517	IMP dehydrogenase activity
HV345_RS06835	COG1069	ribulokinase activity
HV345_RS06845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV345_RS06850	COG1129	ABC transporter
HV345_RS06860	COG3683	transport system, periplasmic component
HV345_RS06865	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV345_RS06890	COG0822	iron-sulfur transferase activity
HV345_RS06910	COG0633	Ferredoxin
HV345_RS06915	COG2975	iron-sulfur cluster assembly
HV345_RS06930	COG1737	Transcriptional regulator
HV345_RS06945	COG2897	thiosulfate sulfurtransferase activity
HV345_RS06950	COG2373	Large extracellular alpha-helical protein
HV345_RS06955	COG4953	penicillin-binding protein 1C
HV345_RS06985	COG2976	Protein conserved in bacteria
HV345_RS07000	COG3104	oligopeptide transport
HV345_RS07010	COG1645	bacterial-type flagellum-dependent swarming motility
HV345_RS07015	COG1570	exodeoxyribonuclease VII activity
HV345_RS07020	COG0517	IMP dehydrogenase activity
HV345_RS07020	COG0516	GMP reductase activity
HV345_RS07035	COG2200	EAL domain
HV345_RS07050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV345_RS07060	COG2723	6-phospho-beta-galactosidase activity
HV345_RS07070	COG2233	PERMEase
HV345_RS07080	COG1393	Belongs to the ArsC family
HV345_RS07085	COG4783	chaperone-mediated protein folding
HV345_RS07090	COG0628	permease
HV345_RS07095	COG3366	ferrous iron transmembrane transporter activity
HV345_RS07100	COG0700	Nucleoside recognition
HV345_RS07105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV345_RS07110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV345_RS07115	COG2716	regulation of RNA biosynthetic process
HV345_RS07125	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV345_RS07135	COG2321	neutral zinc metallopeptidase
HV345_RS07145	COG0400	carboxylic ester hydrolase activity
HV345_RS07160	COG1393	Belongs to the ArsC family
HV345_RS07175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV345_RS07180	COG3850	Histidine kinase
HV345_RS07185	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV345_RS07185	COG0493	'glutamate synthase
HV345_RS07195	COG5342	invasion associated locus B
HV345_RS07200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV345_RS07220	COG4766	ethanolamine catabolic process
HV345_RS07225	COG4812	Cobalamin adenosyltransferase
HV345_RS07290	COG2207	Transcriptional regulator
HV345_RS07300	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV345_RS07320	COG2837	iron assimilation
HV345_RS07325	COG0165	Argininosuccinate lyase
HV345_RS07330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV345_RS07335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV345_RS07340	COG2186	Transcriptional regulator
HV345_RS07350	COG4150	thiosulfate binding
HV345_RS07355	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV345_RS07360	COG4208	sulfate ABC transporter
HV345_RS07365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV345_RS07430	COG3530	Putative quorum-sensing-regulated virulence factor
HV345_RS07435	COG0385	Bile acid
HV345_RS07440	COG0583	DNA-binding transcription factor activity
HV345_RS07450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HV345_RS07455	COG2211	Major facilitator Superfamily
HV345_RS07465	COG0583	DNA-binding transcription factor activity
HV345_RS07500	COG3415	Transposase
HV345_RS07505	COG3415	Transposase
HV345_RS07520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV345_RS07535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV345_RS07540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV345_RS07545	COG1263	PTS System
HV345_RS07545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS07555	COG0667	Aldo Keto reductase
HV345_RS07560	COG3961	Belongs to the TPP enzyme family
HV345_RS07575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS07580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS07585	COG0006	proline dipeptidase activity
HV345_RS07590	COG1363	Peptidase, m42
HV345_RS07605	COG2207	Transcriptional regulator
HV345_RS07610	COG3279	Response regulator of the LytR AlgR family
HV345_RS07615	COG3275	phosphorelay sensor kinase activity
HV345_RS07620	COG0436	Aminotransferase
HV345_RS07635	COG1560	Kdo2-lipid A biosynthetic process
HV345_RS07665	COG3122	Protein conserved in bacteria
HV345_RS07670	COG0840	transmembrane signaling receptor activity
HV345_RS07695	COG2116	formate transmembrane transporter activity
HV345_RS07705	COG2067	long-chain fatty acid transport protein
HV345_RS07710	COG3691	Protein conserved in bacteria
HV345_RS07725	COG2062	phosphohistidine phosphatase, SixA
HV345_RS07750	COG0730	response to heat
HV345_RS07755	COG3101	peptidyl-lysine hydroxylation
HV345_RS07770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV345_RS07810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV345_RS07820	COG0586	Pfam SNARE associated Golgi protein
HV345_RS07830	COG0285	dihydrofolate synthase activity
HV345_RS07835	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV345_RS07840	COG1286	toxin biosynthetic process
HV345_RS07845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV345_RS07850	COG0163	prenyltransferase activity
HV345_RS07860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV345_RS07875	COG4598	ABC transporter
HV345_RS07880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV345_RS07885	COG1090	epimerase
HV345_RS07890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV345_RS07895	COG0625	glutathione transferase activity
HV345_RS07900	COG0625	glutathione transferase activity
HV345_RS07905	COG0622	Phosphoesterase
HV345_RS07915	COG1288	antiporter activity
HV345_RS07940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV345_RS07945	COG0471	metal ion transport
HV345_RS07945	COG0490	domain, Protein
HV345_RS07955	COG0436	Aminotransferase
HV345_RS07960	COG0583	DNA-binding transcription factor activity
HV345_RS07980	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV345_RS08005	COG0839	Belongs to the complex I subunit 6 family
HV345_RS08015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV345_RS08020	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV345_RS08030	COG0784	Response regulator, receiver
HV345_RS08030	COG0835	chemotaxis
HV345_RS08040	COG2153	protein acetylation
HV345_RS08045	COG4575	ribosome binding
HV345_RS08050	COG1169	isochorismate synthase
HV345_RS08135	COG1414	Transcriptional regulator
HV345_RS08145	COG2271	Major facilitator Superfamily
HV345_RS08155	COG0247	lactate metabolic process
HV345_RS08165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV345_RS08170	COG2271	Major facilitator Superfamily
HV345_RS08175	COG0584	glycerophosphoryl diester phosphodiesterase
HV345_RS08180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV345_RS08205	COG0183	Belongs to the thiolase family
HV345_RS08210	COG2031	fatty acid transporter
HV345_RS08215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV345_RS08220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV345_RS08225	COG2204	response regulator
HV345_RS08230	COG3852	Histidine kinase
HV345_RS08245	COG2198	Histidine kinase
HV345_RS08245	COG0642	Histidine kinase
HV345_RS08250	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV345_RS08255	COG1477	protein flavinylation
HV345_RS08260	COG2169	Transcriptional regulator
HV345_RS08260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV345_RS08265	COG3145	DNA-N1-methyladenine dioxygenase activity
HV345_RS08270	COG4615	Cyclic peptide transporter
HV345_RS08275	COG2239	Acts as a magnesium transporter
HV345_RS08280	COG0659	secondary active sulfate transmembrane transporter activity
HV345_RS08295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV345_RS08295	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV345_RS08300	COG3062	negative regulation of establishment of protein localization
HV345_RS08310	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS08315	COG0348	domain, Protein
HV345_RS08320	COG3043	anaerobic respiration
HV345_RS08325	COG3005	denitrification pathway
HV345_RS08330	COG4133	protoheme IX ABC transporter activity
HV345_RS08340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV345_RS08345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV345_RS08355	COG1138	Cytochrome C-type biogenesis protein
HV345_RS08360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV345_RS08365	COG4235	cytochrome complex assembly
HV345_RS08365	COG3088	subunit of a heme lyase
HV345_RS08370	COG2197	response regulator
HV345_RS08400	COG1061	Type III restriction enzyme res subunit
HV345_RS08405	COG1187	pseudouridine synthase activity
HV345_RS08420	COG4172	Belongs to the ABC transporter superfamily
HV345_RS08425	COG4239	(ABC) transporter, permease
HV345_RS08430	COG4174	ABC transporter (Permease)
HV345_RS08435	COG4166	transmembrane transport
HV345_RS08440	COG2200	EAL domain
HV345_RS08445	COG0791	NLP P60 protein
HV345_RS08450	COG0671	phosphoesterase, PA-phosphatase related
HV345_RS08455	COG0523	cobalamin synthesis protein
HV345_RS08460	COG0246	Mannitol dehydrogenase
HV345_RS08465	COG1312	Catalyzes the dehydration of D-mannonate
HV345_RS08470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV345_RS08475	COG3005	denitrification pathway
HV345_RS08485	COG3381	protein complex oligomerization
HV345_RS08510	COG1105	Belongs to the carbohydrate kinase PfkB family
HV345_RS08515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS08515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS08515	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV345_RS08520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV345_RS08530	COG0583	DNA-binding transcription factor activity
HV345_RS08535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS08540	COG2313	pseudouridylate synthase activity
HV345_RS08545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV345_RS08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS08550	COG1522	sequence-specific DNA binding
HV345_RS08560	COG2855	membrane
HV345_RS08565	COG0583	DNA-binding transcription factor activity
HV345_RS08570	COG0833	amino acid
HV345_RS08575	COG4771	TonB-dependent receptor
HV345_RS08590	COG2311	Membrane
HV345_RS08605	COG1129	ABC transporter
HV345_RS08620	COG0493	'glutamate synthase
HV345_RS08630	COG2949	membrane
HV345_RS08640	COG1346	cytolysis
HV345_RS08655	COG2271	Major facilitator Superfamily
HV345_RS08670	COG0625	glutathione transferase activity
HV345_RS08675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV345_RS08680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV345_RS08695	COG0586	Pfam SNARE associated Golgi protein
HV345_RS08705	COG1686	Belongs to the peptidase S11 family
HV345_RS08710	COG0277	FAD linked oxidase domain protein
HV345_RS08715	COG1472	Belongs to the glycosyl hydrolase 3 family
HV345_RS08720	COG1732	Glycine betaine
HV345_RS08725	COG1174	glycine betaine transport
HV345_RS08730	COG1125	glycine betaine transport
HV345_RS08735	COG1174	glycine betaine transport
HV345_RS08745	COG0789	Transcriptional regulator
HV345_RS08750	COG3275	phosphorelay sensor kinase activity
HV345_RS08760	COG4807	Protein conserved in bacteria
HV345_RS08765	COG4808	Protein conserved in bacteria
HV345_RS08790	COG3121	Chaperone
HV345_RS08795	COG3188	usher protein
HV345_RS08805	COG5455	response to cobalt ion
HV345_RS08815	COG0351	phosphomethylpyrimidine kinase
HV345_RS08820	COG2188	Transcriptional regulator
HV345_RS08825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS08830	COG1397	ADP-ribosylglycohydrolase
HV345_RS08835	COG2211	Major facilitator Superfamily
HV345_RS08840	COG1830	Aldolase
HV345_RS08850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV345_RS08855	COG4160	amino acid transport
HV345_RS08860	COG4215	(ABC) transporter
HV345_RS08865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV345_RS08870	COG1126	abc transporter atp-binding protein
HV345_RS08885	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV345_RS08890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV345_RS08895	COG0702	epimerase
HV345_RS08900	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV345_RS08905	COG0028	Belongs to the TPP enzyme family
HV345_RS08915	COG4529	Protein conserved in bacteria
HV345_RS08920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV345_RS08930	COG2431	L-lysine efflux transmembrane transporter activity
HV345_RS08940	COG3593	DNA synthesis involved in DNA repair
HV345_RS08945	COG2990	Protein conserved in bacteria
HV345_RS08950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV345_RS08960	COG1278	Cold shock
HV345_RS08970	COG0542	response to heat
HV345_RS08985	COG0745	RESPONSE REGULATOR receiver
HV345_RS08990	COG2205	protein histidine kinase activity
HV345_RS09020	COG0443	Heat shock 70 kDa protein
HV345_RS09025	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV345_RS09030	COG5002	protein histidine kinase activity
HV345_RS09030	COG5001	Diguanylate cyclase
HV345_RS09030	COG3447	MASE1 domain protein
HV345_RS09045	COG2982	Protein involved in outer membrane biogenesis
HV345_RS09050	COG1253	flavin adenine dinucleotide binding
HV345_RS09070	COG0463	Glycosyl transferase, family 2
HV345_RS09075	COG1045	serine acetyltransferase
HV345_RS09080	COG0438	transferase activity, transferring glycosyl groups
HV345_RS09090	COG1216	Glycosyl transferase, family 2
HV345_RS09095	COG0110	maltose O-acetyltransferase activity
HV345_RS09100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV345_RS09105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV345_RS09110	COG1051	belongs to the nudix hydrolase family
HV345_RS09115	COG0297	glycogen (starch) synthase activity
HV345_RS09120	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HV345_RS09120	COG0662	Cupin 2, conserved barrel domain protein
HV345_RS09125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV345_RS09130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV345_RS09135	COG2244	polysaccharide biosynthetic process
HV345_RS09140	COG2327	Polysaccharide pyruvyl transferase
HV345_RS09190	COG1442	glycosyl transferase family 8
HV345_RS09205	COG0562	UDP-galactopyranose mutase
HV345_RS09215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV345_RS09220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HV345_RS09240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV345_RS09270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV345_RS09275	COG0583	DNA-binding transcription factor activity
HV345_RS09285	COG0531	amino acid
HV345_RS09290	COG2925	Exonuclease
HV345_RS09320	COG1289	transmembrane transporter activity
HV345_RS09355	COG4656	Part of a membrane complex involved in electron transport
HV345_RS09545	COG1376	ErfK ybiS ycfS ynhG family protein
HV345_RS09555	COG1178	ABC-type Fe3 transport system permease component
HV345_RS09560	COG1840	ABC-type Fe3 transport system, periplasmic component
HV345_RS09595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV345_RS09600	COG1418	mRNA catabolic process
HV345_RS09605	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV345_RS09610	COG3727	T/G mismatch-specific endonuclease activity
HV345_RS09615	COG0697	spore germination
HV345_RS09620	COG2354	Protein conserved in bacteria
HV345_RS09625	COG5475	Uncharacterized small protein (DUF2158)
HV345_RS09685	COG2882	bacterial-type flagellum organization
HV345_RS09715	COG0425	Belongs to the sulfur carrier protein TusA family
HV345_RS09730	COG0366	Alpha amylase catalytic
HV345_RS09790	COG2197	response regulator
HV345_RS09800	COG2197	response regulator
HV345_RS09835	COG1278	Cold shock
HV345_RS09845	COG0431	NADPH-dependent FMN reductase
HV345_RS09850	COG0640	Transcriptional regulator
HV345_RS09880	COG1305	Transglutaminase-like
HV345_RS09890	COG2608	mercury ion transmembrane transporter activity
HV345_RS09895	COG3012	SEC-C Motif Domain Protein
HV345_RS09895	COG3318	Belongs to the UPF0149 family
HV345_RS09900	COG0814	amino acid
HV345_RS09910	COG1528	Iron-storage protein
HV345_RS09925	COG0477	Major facilitator Superfamily
HV345_RS09935	COG1528	Iron-storage protein
HV345_RS09945	COG1879	ABC-type sugar transport system periplasmic component
HV345_RS09950	COG1129	ABC transporter
HV345_RS09955	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV345_RS10000	COG0835	chemotaxis
HV345_RS10005	COG1301	dicarboxylic acid transport
HV345_RS10015	COG0840	transmembrane signaling receptor activity
HV345_RS10030	COG0745	RESPONSE REGULATOR receiver
HV345_RS10040	COG4977	sequence-specific DNA binding
HV345_RS10045	COG2814	Major facilitator Superfamily
HV345_RS10050	COG3250	beta-galactosidase activity
HV345_RS10075	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV345_RS10090	COG3102	Protein conserved in bacteria
HV345_RS10110	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV345_RS10115	COG1801	Protein of unknown function DUF72
HV345_RS10120	COG0582	viral genome integration into host DNA
HV345_RS10140	COG0592	DNA-directed DNA polymerase activity
HV345_RS10185	COG4197	protein conserved in bacteria, prophage-related
HV345_RS10210	COG0484	heat shock protein binding
HV345_RS10260	COG1802	Transcriptional regulator
HV345_RS10260	COG4626	Terminase
HV345_RS10270	COG4695	Portal protein
HV345_RS10405	COG1335	isochorismatase
HV345_RS10415	COG0494	nUDIX hydrolase
HV345_RS10435	COG2255	four-way junction helicase activity
HV345_RS10440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV345_RS10460	COG1187	pseudouridine synthase activity
HV345_RS10465	COG0538	isocitrate dehydrogenase activity
HV345_RS10470	COG2814	Major facilitator Superfamily
HV345_RS10475	COG1414	Transcriptional regulator
HV345_RS10505	COG0768	penicillin binding
HV345_RS10510	COG2226	methyltransferase
HV345_RS10525	COG3716	PTS system mannose fructose sorbose family IID component
HV345_RS10530	COG3715	PTS system
HV345_RS10535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS10535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS10540	COG1253	flavin adenine dinucleotide binding
HV345_RS10545	COG2200	EAL domain
HV345_RS10550	COG1760	l-serine dehydratase
HV345_RS10570	COG0251	oxidation-reduction process
HV345_RS10575	COG1199	ATP-dependent helicase activity
HV345_RS10580	COG1214	PFAM Peptidase M22, glycoprotease
HV345_RS10585	COG3065	identical protein binding
HV345_RS10590	COG0318	PFAM AMP-dependent synthetase and ligase
HV345_RS10595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV345_RS10600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV345_RS10605	COG4638	Rieske (2fe-2S)
HV345_RS10610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV345_RS10615	COG0473	3-isopropylmalate dehydrogenase activity
HV345_RS10620	COG0583	DNA-binding transcription factor activity
HV345_RS10630	COG2894	cell division
HV345_RS10645	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV345_RS10675	COG2719	SpoVR family
HV345_RS10685	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS10695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV345_RS10705	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV345_RS10730	COG0157	Belongs to the NadC ModD family
HV345_RS10735	COG0500	methyltransferase
HV345_RS10740	COG1120	ATPase activity
HV345_RS10765	COG1461	Dihydroxyacetone kinase
HV345_RS10770	COG2376	Dihydroxyacetone kinase
HV345_RS10775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV345_RS10800	COG0789	Transcriptional regulator
HV345_RS10805	COG2200	EAL domain
HV345_RS10835	COG0702	epimerase
HV345_RS10845	COG0667	Aldo Keto reductase
HV345_RS10850	COG0656	L-ascorbic acid biosynthetic process
HV345_RS10870	COG0300	oxidoreductase activity
HV345_RS10880	COG0204	Acyl-transferase
HV345_RS10880	COG0318	PFAM AMP-dependent synthetase and ligase
HV345_RS10885	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS10920	COG5002	protein histidine kinase activity
HV345_RS10935	COG0012	GTP binding
HV345_RS10950	COG0527	aspartate kinase activity
HV345_RS10955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV345_RS10960	COG0076	glutamate decarboxylase activity
HV345_RS10965	COG0659	secondary active sulfate transmembrane transporter activity
HV345_RS10995	COG2890	protein-(glutamine-N5) methyltransferase activity
HV345_RS11000	COG3094	Invasion gene expression up-regulator, SirB
HV345_RS11015	COG0387	Pfam Sodium calcium exchanger
HV345_RS11020	COG4572	Cation transport regulator
HV345_RS11025	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV345_RS11035	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV345_RS11040	COG4932	domain protein
HV345_RS11045	COG2197	response regulator
HV345_RS11050	COG3850	Histidine kinase
HV345_RS11055	COG2223	nitrite transmembrane transporter activity
HV345_RS11060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV345_RS11065	COG1140	nitrate reductase beta subunit
HV345_RS11070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV345_RS11075	COG2181	nitrate reductase activity
HV345_RS11100	COG0788	formyltetrahydrofolate deformylase activity
HV345_RS11110	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV345_RS11115	COG0745	RESPONSE REGULATOR receiver
HV345_RS11120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV345_RS11130	COG1435	thymidine kinase activity
HV345_RS11135	COG1454	alcohol dehydrogenase
HV345_RS11135	COG1012	belongs to the aldehyde dehydrogenase family
HV345_RS11140	COG2095	MarC family integral membrane protein
HV345_RS11160	COG0444	Belongs to the ABC transporter superfamily
HV345_RS11170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV345_RS11190	COG2350	Protein conserved in bacteria
HV345_RS11215	COG3047	cAMP biosynthetic process
HV345_RS11225	COG3706	GGDEF domain
HV345_RS11265	COG0009	L-threonylcarbamoyladenylate synthase
HV345_RS11270	COG1187	pseudouridine synthase activity
HV345_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS11285	COG0616	signal peptide processing
HV345_RS11300	COG0583	DNA-binding transcription factor activity
HV345_RS11315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV345_RS11325	COG0671	phosphoesterase, PA-phosphatase related
HV345_RS11330	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV345_RS11335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV345_RS11345	COG0023	Translation Initiation Factor
HV345_RS11355	COG1349	DNA-binding transcription factor activity
HV345_RS11365	COG5001	Diguanylate cyclase
HV345_RS11375	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV345_RS11375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV345_RS11380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV345_RS11395	COG4172	Belongs to the ABC transporter superfamily
HV345_RS11400	COG4171	peptide transport system, permease
HV345_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS11420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV345_RS11425	COG1842	Phage shock protein A
HV345_RS11435	COG1983	PspC domain protein
HV345_RS11445	COG0366	Alpha amylase catalytic
HV345_RS11450	COG1653	transport
HV345_RS11455	COG1175	transmembrane transport
HV345_RS11460	COG0395	ABC-type sugar transport system, permease component
HV345_RS11465	COG1063	alcohol dehydrogenase
HV345_RS11470	COG1082	Xylose isomerase domain protein TIM barrel
HV345_RS11475	COG0673	inositol 2-dehydrogenase activity
HV345_RS11480	COG1554	hydrolase, family 65, central catalytic
HV345_RS11485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV345_RS11500	COG1609	Transcriptional regulator
HV345_RS11505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV345_RS11510	COG3106	COG3106 Predicted ATPase
HV345_RS11525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV345_RS11530	COG4948	Mandelate Racemase Muconate Lactonizing
HV345_RS11535	COG2866	Carboxypeptidase
HV345_RS11540	COG4166	transmembrane transport
HV345_RS11545	COG1349	DNA-binding transcription factor activity
HV345_RS11550	COG0346	lactoylglutathione lyase activity
HV345_RS11565	COG0668	transmembrane transport
HV345_RS11570	COG3182	Iron-regulated membrane protein
HV345_RS11590	COG2840	Smr protein MutS2
HV345_RS11595	COG3706	GGDEF domain
HV345_RS11605	COG0840	transmembrane signaling receptor activity
HV345_RS11620	COG0513	Belongs to the DEAD box helicase family
HV345_RS11630	COG0589	response to stress
HV345_RS11640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV345_RS11645	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV345_RS11645	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV345_RS11645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV345_RS11645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV345_RS11650	COG3042	response to heat
HV345_RS11655	COG3187	Heat shock protein
HV345_RS11660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV345_RS11675	COG3784	Protein of unknown function (DUF1318)
HV345_RS11690	COG1643	Atp-dependent helicase
HV345_RS11695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV345_RS11700	COG1012	belongs to the aldehyde dehydrogenase family
HV345_RS11705	COG3038	cytochrome b561
HV345_RS11710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV345_RS11715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV345_RS11735	COG0840	transmembrane signaling receptor activity
HV345_RS11740	COG0583	DNA-binding transcription factor activity
HV345_RS11745	COG1227	inorganic diphosphatase activity
HV345_RS11750	COG5383	Protein conserved in bacteria
HV345_RS11760	COG2841	Protein conserved in bacteria
HV345_RS11765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV345_RS11770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV345_RS11775	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV345_RS11780	COG0500	methyltransferase
HV345_RS11800	COG3135	benzoate transporter
HV345_RS11805	COG1396	sequence-specific DNA binding
HV345_RS11810	COG0826	peptidase U32
HV345_RS11825	COG1294	oxidase, subunit
HV345_RS11830	COG1271	oxidase subunit
HV345_RS11835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV345_RS11840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV345_RS11845	COG3842	ATPase activity
HV345_RS11850	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV345_RS11855	COG1177	transmembrane transport
HV345_RS11865	COG2814	Major facilitator Superfamily
HV345_RS11900	COG0747	negative chemotaxis
HV345_RS11910	COG3238	Protein conserved in bacteria
HV345_RS11915	COG1247	-acetyltransferase
HV345_RS11925	COG2130	NADP-dependent
HV345_RS11930	COG4772	TonB-dependent receptor
HV345_RS11970	COG0840	transmembrane signaling receptor activity
HV345_RS11975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV345_RS11980	COG1473	amidohydrolase
HV345_RS11985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV345_RS11990	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV345_RS12005	COG1126	abc transporter atp-binding protein
HV345_RS12010	COG0625	glutathione transferase activity
HV345_RS12015	COG2271	Major facilitator Superfamily
HV345_RS12025	COG1609	Transcriptional regulator
HV345_RS12035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV345_RS12040	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV345_RS12045	COG0384	phenazine biosynthesis protein PhzF
HV345_RS12050	COG2181	nitrate reductase activity
HV345_RS12055	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV345_RS12060	COG1140	nitrate reductase beta subunit
HV345_RS12065	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV345_RS12070	COG2223	nitrite transmembrane transporter activity
HV345_RS12105	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS12110	COG2864	formate dehydrogenase
HV345_RS12125	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS12140	COG1764	response to oxidative stress
HV345_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS12150	COG2610	gluconate transmembrane transporter activity
HV345_RS12155	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV345_RS12165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV345_RS12170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV345_RS12180	COG4608	Belongs to the ABC transporter superfamily
HV345_RS12185	COG0444	Belongs to the ABC transporter superfamily
HV345_RS12190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV345_RS12195	COG0601	transmembrane transport
HV345_RS12200	COG0747	negative chemotaxis
HV345_RS12205	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV345_RS12220	COG0840	transmembrane signaling receptor activity
HV345_RS12230	COG4628	conserved protein (DUF2132)
HV345_RS12280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV345_RS12320	COG3781	membrane
HV345_RS12345	COG1012	belongs to the aldehyde dehydrogenase family
HV345_RS12350	COG0583	DNA-binding transcription factor activity
HV345_RS12365	COG1846	Transcriptional regulator
HV345_RS12380	COG0697	spore germination
HV345_RS12390	COG0410	ABC transporter
HV345_RS12395	COG1129	ABC transporter
HV345_RS12420	COG0339	signal peptide processing
HV345_RS12425	COG4221	oxidoreductase activity
HV345_RS12430	COG1802	Transcriptional regulator
HV345_RS12440	COG0246	Mannitol dehydrogenase
HV345_RS12445	COG0477	Major facilitator Superfamily
HV345_RS12450	COG1063	alcohol dehydrogenase
HV345_RS12455	COG4948	Mandelate Racemase Muconate Lactonizing
HV345_RS12470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV345_RS12485	COG0243	molybdopterin cofactor binding
HV345_RS12490	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS12495	COG3302	dmso reductase anchor subunit
HV345_RS12500	COG3381	protein complex oligomerization
HV345_RS12510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV345_RS12515	COG1940	carbohydrate kinase activity
HV345_RS12520	COG0583	DNA-binding transcription factor activity
HV345_RS12525	COG2814	Major facilitator Superfamily
HV345_RS12535	COG5002	protein histidine kinase activity
HV345_RS12540	COG0745	RESPONSE REGULATOR receiver
HV345_RS12555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV345_RS12565	COG3591	Belongs to the peptidase S1B family
HV345_RS12580	COG0628	permease
HV345_RS12585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV345_RS12590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV345_RS12600	COG0531	amino acid
HV345_RS12610	COG3136	membrane protein required for alginate biosynthesis
HV345_RS12615	COG0745	RESPONSE REGULATOR receiver
HV345_RS12620	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV345_RS12630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV345_RS12640	COG2205	protein histidine kinase activity
HV345_RS12655	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS12655	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS12660	COG1482	cell wall glycoprotein biosynthetic process
HV345_RS12665	COG5339	Protein conserved in bacteria
HV345_RS12670	COG1609	Transcriptional regulator
HV345_RS12675	COG1263	PTS System
HV345_RS12675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS12680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV345_RS12690	COG0673	inositol 2-dehydrogenase activity
HV345_RS12740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV345_RS12750	COG0625	glutathione transferase activity
HV345_RS12755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV345_RS12770	COG3895	Periplasmic Protein
HV345_RS12795	COG1566	PFAM secretion protein HlyD family protein
HV345_RS12810	COG4989	oxidoreductase activity
HV345_RS12815	COG3313	Fe-S protein
HV345_RS12820	COG1309	transcriptional regulator
HV345_RS12825	COG1902	pentaerythritol trinitrate reductase activity
HV345_RS12830	COG0346	lactoylglutathione lyase activity
HV345_RS12840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV345_RS12845	COG0791	NLP P60 protein
HV345_RS12850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV345_RS12855	COG2814	Major facilitator Superfamily
HV345_RS12870	COG0583	DNA-binding transcription factor activity
HV345_RS12875	COG2814	Major facilitator Superfamily
HV345_RS12880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV345_RS12885	COG0307	riboflavin synthase, alpha
HV345_RS12895	COG0564	pseudouridine synthase activity
HV345_RS12910	COG0251	oxidation-reduction process
HV345_RS12935	COG5001	Diguanylate cyclase
HV345_RS12935	COG3300	MHYT domain
HV345_RS12940	COG3272	Protein of unknown function (DUF1722)
HV345_RS12945	COG0628	permease
HV345_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS12975	COG0583	DNA-binding transcription factor activity
HV345_RS12980	COG0477	Major facilitator Superfamily
HV345_RS12995	COG1942	4-Oxalocrotonate Tautomerase
HV345_RS13005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV345_RS13015	COG0251	oxidation-reduction process
HV345_RS13030	COG1114	Component of the transport system for branched-chain amino acids
HV345_RS13060	COG4977	sequence-specific DNA binding
HV345_RS13070	COG0386	Belongs to the glutathione peroxidase family
HV345_RS13105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV345_RS13120	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV345_RS13130	COG1012	belongs to the aldehyde dehydrogenase family
HV345_RS13145	COG1113	amino acid transport
HV345_RS13155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV345_RS13165	COG0765	amino acid transport
HV345_RS13170	COG0765	amino acid transport
HV345_RS13180	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV345_RS13185	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS13195	COG2414	aldehyde ferredoxin oxidoreductase
HV345_RS13200	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS13235	COG1464	Belongs to the NlpA lipoprotein family
HV345_RS13240	COG2011	ABC-type metal ion transport system permease component
HV345_RS13260	COG1376	ErfK ybiS ycfS ynhG family protein
HV345_RS13275	COG0719	Fe-S assembly protein
HV345_RS13280	COG0396	ATPase activity
HV345_RS13285	COG0719	Fe-S assembly protein
HV345_RS13290	COG0316	Belongs to the HesB IscA family
HV345_RS13310	COG2050	protein possibly involved in aromatic compounds catabolism
HV345_RS13315	COG0277	FAD linked oxidase domain protein
HV345_RS13315	COG0247	lactate metabolic process
HV345_RS13320	COG0628	permease
HV345_RS13335	COG0738	Major facilitator superfamily
HV345_RS13340	COG2271	Major facilitator Superfamily
HV345_RS13355	COG4670	ketone body catabolic process
HV345_RS13360	COG1960	acyl-CoA dehydrogenase activity
HV345_RS13365	COG2207	Transcriptional regulator
HV345_RS13365	COG1917	Cupin 2, conserved barrel domain protein
HV345_RS13370	COG2086	electron transfer activity
HV345_RS13375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV345_RS13380	COG0644	oxidoreductase
HV345_RS13385	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV345_RS13390	COG0318	PFAM AMP-dependent synthetase and ligase
HV345_RS13395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV345_RS13395	COG0574	Belongs to the PEP-utilizing enzyme family
HV345_RS13405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV345_RS13410	COG4256	Hemin uptake protein
HV345_RS13415	COG4771	TonB-dependent receptor
HV345_RS13420	COG3720	iron ion transport
HV345_RS13425	COG4558	Periplasmic binding protein
HV345_RS13430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV345_RS13450	COG0791	NLP P60 protein
HV345_RS13460	COG0386	Belongs to the glutathione peroxidase family
HV345_RS13475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS13490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV345_RS13520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV345_RS13540	COG3137	Salt-induced outer membrane protein
HV345_RS13545	COG1105	Belongs to the carbohydrate kinase PfkB family
HV345_RS13550	COG3001	Fructosamine kinase
HV345_RS13560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV345_RS13570	COG1988	membrane-bound metal-dependent
HV345_RS13585	COG0753	catalase activity
HV345_RS13595	COG1486	melibiose metabolic process
HV345_RS13605	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV345_RS13610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV345_RS13615	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV345_RS13620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV345_RS13630	COG0322	excinuclease ABC activity
HV345_RS13640	COG3678	ATP-independent chaperone mediated protein folding
HV345_RS13670	COG0708	Exodeoxyribonuclease III
HV345_RS13675	COG0398	Pfam SNARE associated Golgi protein
HV345_RS13680	COG0398	Pfam SNARE associated Golgi protein
HV345_RS13685	COG4134	Bacterial extracellular solute-binding protein
HV345_RS13690	COG4135	transport system, permease component
HV345_RS13695	COG4136	ATPase activity
HV345_RS13700	COG2897	thiosulfate sulfurtransferase activity
HV345_RS13705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV345_RS13710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV345_RS13715	COG0494	nUDIX hydrolase
HV345_RS13730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV345_RS13740	COG0778	Nitroreductase
HV345_RS13745	COG0616	signal peptide processing
HV345_RS13750	COG0252	asparaginase activity
HV345_RS13755	COG1335	isochorismatase
HV345_RS13770	COG3139	Protein of unknown function (DUF1315)
HV345_RS13790	COG0656	L-ascorbic acid biosynthetic process
HV345_RS13805	COG3713	MltA-interacting MipA family protein
HV345_RS13810	COG2766	serine protein kinase
HV345_RS13820	COG0110	maltose O-acetyltransferase activity
HV345_RS13830	COG2226	methyltransferase
HV345_RS13835	COG2199	diguanylate cyclase activity
HV345_RS13840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV345_RS13850	COG2207	Transcriptional regulator
HV345_RS13855	COG2807	transmembrane transport
HV345_RS13860	COG0504	CTP synthase activity
HV345_RS13865	COG3189	MarR family transcriptional regulator
HV345_RS13870	COG3042	response to heat
HV345_RS13875	COG2199	diguanylate cyclase activity
HV345_RS13875	COG2203	Gaf domain
HV345_RS13890	COG2261	transglycosylase associated protein
HV345_RS13895	COG3383	formate dehydrogenase (NAD+) activity
HV345_RS13910	COG3615	Tellurite resistance protein tehB
HV345_RS13920	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV345_RS13935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV345_RS13940	COG0601	transmembrane transport
HV345_RS13945	COG0747	negative chemotaxis
HV345_RS13950	COG4771	TonB-dependent receptor
HV345_RS13970	COG1956	GAF domain-containing protein
HV345_RS13975	COG2995	paraquat-inducible protein a
HV345_RS13980	COG3008	intermembrane lipid transfer
HV345_RS14015	COG1276	copper resistance
HV345_RS14020	COG2372	response to copper ion
HV345_RS14030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV345_RS14035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV345_RS14040	COG1770	oligopeptidase
HV345_RS14045	COG2979	Protein of unknown function (DUF533)
HV345_RS14055	COG3141	response to X-ray
HV345_RS14065	COG0800	Aldolase
HV345_RS14070	COG0129	dihydroxy-acid dehydratase activity
HV345_RS14075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV345_RS14080	COG1737	Transcriptional regulator
HV345_RS14090	COG1560	Kdo2-lipid A biosynthetic process
HV345_RS14095	COG0739	heme binding
HV345_RS14100	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV345_RS14110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV345_RS14125	COG2850	peptidyl-arginine hydroxylation
HV345_RS14175	COG1289	transmembrane transporter activity
HV345_RS14190	COG1278	Cold shock
HV345_RS14205	COG1177	transmembrane transport
HV345_RS14215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV345_RS14225	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV345_RS14230	COG1136	(ABC) transporter
HV345_RS14235	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV345_RS14240	COG4763	Acyl-transferase
HV345_RS14245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV345_RS14250	COG1376	ErfK ybiS ycfS ynhG family protein
HV345_RS14250	COG1388	LysM domain
HV345_RS14260	COG1309	transcriptional regulator
HV345_RS14270	COG3134	Outer membrane lipoprotein
HV345_RS14275	COG1252	NADH dehydrogenase
HV345_RS14300	COG5633	Lipoprotein
HV345_RS14305	COG0537	adenosine 5'-monophosphoramidase activity
HV345_RS14310	COG4773	Receptor
HV345_RS14320	COG3039	Transposase
HV345_RS14335	COG0309	Hydrogenase expression formation protein (HypE)
HV345_RS14345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV345_RS14350	COG2223	nitrite transmembrane transporter activity
HV345_RS14360	COG0534	Mate efflux family protein
HV345_RS14370	COG0583	DNA-binding transcription factor activity
HV345_RS14390	COG0477	Major facilitator Superfamily
HV345_RS14395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV345_RS14400	COG0006	proline dipeptidase activity
HV345_RS14410	COG0084	hydrolase, TatD family'
HV345_RS14415	COG0470	DNA polymerase III
HV345_RS14425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV345_RS14430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV345_RS14445	COG3188	usher protein
HV345_RS14450	COG3539	Fimbrial protein
HV345_RS14455	COG3539	Fimbrial protein
HV345_RS14465	COG3121	Chaperone
HV345_RS14470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV345_RS14505	COG1399	metal-binding, possibly nucleic acid-binding protein
HV345_RS14515	COG0564	pseudouridine synthase activity
HV345_RS14520	COG1530	ribonuclease E activity
HV345_RS14530	COG1256	bacterial-type flagellum assembly
HV345_RS14550	COG4786	Flagellar basal body rod
HV345_RS14555	COG4787	bacterial-type flagellum-dependent cell motility
HV345_RS14570	COG1558	bacterial-type flagellum-dependent cell motility
HV345_RS14610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV345_RS14650	COG3038	cytochrome b561
HV345_RS14665	COG1560	Kdo2-lipid A biosynthetic process
HV345_RS14675	COG5645	(Lipo)protein
HV345_RS14695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV345_RS14750	COG3381	protein complex oligomerization
HV345_RS14795	COG1702	phosphate starvation-inducible protein PhoH
HV345_RS14820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV345_RS14825	COG0506	proline dehydrogenase activity
HV345_RS14825	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV345_RS14825	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV345_RS14830	COG3755	Protein conserved in bacteria
HV345_RS14835	COG1309	transcriptional regulator
HV345_RS14845	COG3729	General stress protein
HV345_RS14865	COG0640	Transcriptional regulator
HV345_RS14875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV345_RS14880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV345_RS14880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV345_RS14930	COG0813	purine-nucleoside phosphorylase activity
HV345_RS14950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV345_RS14955	COG1120	ATPase activity
HV345_RS14970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV345_RS14970	COG2857	Cytochrome c1
HV345_RS14985	COG4166	transmembrane transport
HV345_RS14990	COG0670	Belongs to the BI1 family
HV345_RS15030	COG2920	part of a sulfur-relay system
HV345_RS15050	COG1832	CoA-binding protein
HV345_RS15065	COG0210	DNA helicase
HV345_RS15070	COG3304	Inner membrane component domain
HV345_RS15075	COG1289	transmembrane transporter activity
HV345_RS15080	COG3070	regulator of competence-specific genes
HV345_RS15100	COG1067	ATP-dependent peptidase activity
HV345_RS15110	COG3130	regulation of translation
HV345_RS15115	COG3009	Protein conserved in bacteria
HV345_RS15120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV345_RS15120	COG3008	intermembrane lipid transfer
HV345_RS15125	COG2995	paraquat-inducible protein a
HV345_RS15130	COG0488	(ABC) transporter
HV345_RS15140	COG0633	Ferredoxin
HV345_RS15140	COG3217	Mosc domain protein beta barrel domain protein
HV345_RS15155	COG0431	NADPH-dependent FMN reductase
HV345_RS15160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV345_RS15170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV345_RS15180	COG0308	aminopeptidase N
HV345_RS15200	COG1448	Aminotransferase
HV345_RS15205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV345_RS15210	COG3108	Peptidase M15
HV345_RS15215	COG2989	Protein conserved in bacteria
HV345_RS15225	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV345_RS15235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV345_RS15240	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV345_RS15245	COG3173	Aminoglycoside phosphotransferase
HV345_RS15260	COG3214	Protein conserved in bacteria
HV345_RS15275	COG2333	competence protein COMEC
HV345_RS15275	COG0658	competence protein
HV345_RS15280	COG0776	regulation of translation
HV345_RS15285	COG0539	negative regulation of cytoplasmic translation
HV345_RS15305	COG2323	membrane
HV345_RS15310	COG1944	ATP diphosphatase activity
HV345_RS15315	COG2116	formate transmembrane transporter activity
HV345_RS15320	COG1882	Formate acetyltransferase
HV345_RS15325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV345_RS15350	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS15370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV345_RS15390	COG0492	ferredoxin-NADP+ reductase activity
HV345_RS15395	COG4988	ABC transporter
HV345_RS15400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV345_RS15415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV345_RS15420	COG0583	DNA-binding transcription factor activity
HV345_RS15430	COG1335	isochorismatase
HV345_RS15440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV345_RS15450	COG1177	transmembrane transport
HV345_RS15455	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV345_RS15460	COG3842	ATPase activity
HV345_RS15465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV345_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS15510	COG3226	Transcriptional regulator
HV345_RS15515	COG0738	Major facilitator superfamily
HV345_RS15520	COG0561	phosphatase activity
HV345_RS15530	COG2814	Major facilitator Superfamily
HV345_RS15535	COG0671	phosphoesterase, PA-phosphatase related
HV345_RS15540	COG1349	DNA-binding transcription factor activity
HV345_RS15545	COG1686	Belongs to the peptidase S11 family
HV345_RS15550	COG0625	glutathione transferase activity
HV345_RS15555	COG2133	pyrroloquinoline quinone binding
HV345_RS15650	COG1446	asparaginase
HV345_RS15660	COG0303	'Molybdopterin
HV345_RS15665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV345_RS15670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV345_RS15675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV345_RS15680	COG1882	Formate acetyltransferase
HV345_RS15685	COG0561	phosphatase activity
HV345_RS15695	COG0488	(ABC) transporter
HV345_RS15700	COG1376	ErfK ybiS ycfS ynhG family protein
HV345_RS15705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV345_RS15720	COG2194	sulfuric ester hydrolase activity
HV345_RS15725	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV345_RS15740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV345_RS15745	COG0765	amino acid transport
HV345_RS15750	COG1126	abc transporter atp-binding protein
HV345_RS15755	COG0668	transmembrane transport
HV345_RS15770	COG4774	siderophore transport
HV345_RS15780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV345_RS15790	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV345_RS15795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV345_RS15805	COG0513	Belongs to the DEAD box helicase family
HV345_RS15810	COG1309	transcriptional regulator
HV345_RS15820	COG1131	(ABC) transporter
HV345_RS15825	COG0842	Transport permease protein
HV345_RS15830	COG0842	Transport permease protein
HV345_RS15840	COG3568	Endonuclease Exonuclease Phosphatase
HV345_RS15845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV345_RS15850	COG0392	lysyltransferase activity
HV345_RS15855	COG0670	Belongs to the BI1 family
HV345_RS15860	COG0314	molybdopterin synthase activity
HV345_RS15865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV345_RS15875	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV345_RS15890	COG1757	Na H antiporter
HV345_RS15895	COG0626	cystathionine gamma-synthase activity
HV345_RS15910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV345_RS15945	COG1881	PFAM PEBP family protein
HV345_RS15975	COG4677	pectinesterase activity
HV345_RS15985	COG0561	phosphatase activity
HV345_RS15995	COG4149	molybdate abc transporter
HV345_RS16000	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV345_RS16010	COG3585	molybdate ion transport
HV345_RS16010	COG2005	Transcriptional regulator
HV345_RS16015	COG1119	ATPase activity
HV345_RS16020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV345_RS16025	COG1085	galactose-1-phosphate uridylyltransferase
HV345_RS16035	COG2017	converts alpha-aldose to the beta-anomer
HV345_RS16045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV345_RS16055	COG1230	cation diffusion facilitator family transporter
HV345_RS16060	COG3201	nicotinamide mononucleotide transporter
HV345_RS16100	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV345_RS16105	COG2885	chlorophyll binding
HV345_RS16115	COG3064	Membrane
HV345_RS16120	COG0848	biopolymer transport protein
HV345_RS16125	COG0811	peptide transport
HV345_RS16130	COG0824	Thioesterase
HV345_RS16135	COG3790	cyd operon protein YbgE
HV345_RS16140	COG4890	Cyd operon protein YbgT
HV345_RS16145	COG1294	oxidase, subunit
HV345_RS16150	COG1271	oxidase subunit
HV345_RS16155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV345_RS16165	COG4865	methylaspartate mutase activity
HV345_RS16170	COG3799	methylaspartate ammonia-lyase activity
HV345_RS16185	COG1301	dicarboxylic acid transport
HV345_RS16195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS16195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS16205	COG0583	DNA-binding transcription factor activity
HV345_RS16210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV345_RS16210	COG1648	precorrin-2 dehydrogenase activity
HV345_RS16220	COG3395	kinase activity
HV345_RS16225	COG0235	Class ii aldolase
HV345_RS16230	COG1349	DNA-binding transcription factor activity
HV345_RS16235	COG3622	Belongs to the hyi family
HV345_RS16240	COG3246	L-lysine catabolic process to acetate
HV345_RS16265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS16265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS16265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS16270	COG2188	Transcriptional regulator
HV345_RS16275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV345_RS16285	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV345_RS16290	COG0567	Dehydrogenase, E1 component
HV345_RS16295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV345_RS16300	COG1053	succinate dehydrogenase
HV345_RS16305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV345_RS16310	COG2009	succinate dehydrogenase
HV345_RS16320	COG3180	Ammonia monooxygenase
HV345_RS16350	COG1984	allophanate hydrolase subunit 2
HV345_RS16355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV345_RS16370	COG5464	transposase or invertase
HV345_RS16405	COG2205	protein histidine kinase activity
HV345_RS16410	COG0745	RESPONSE REGULATOR receiver
HV345_RS16420	COG1982	Orn Lys Arg decarboxylase major
HV345_RS16425	COG0531	amino acid
HV345_RS16430	COG0033	Phosphoglucomutase
HV345_RS16435	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV345_RS16440	COG0596	Alpha beta hydrolase
HV345_RS16450	COG0716	FMN binding
HV345_RS16460	COG0735	belongs to the Fur family
HV345_RS16465	COG0583	DNA-binding transcription factor activity
HV345_RS16470	COG1053	succinate dehydrogenase
HV345_RS16495	COG1609	Transcriptional regulator
HV345_RS16505	COG1653	transport
HV345_RS16515	COG1263	PTS System
HV345_RS16515	COG2190	(PTS) system
HV345_RS16515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS16525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV345_RS16530	COG1846	Transcriptional regulator
HV345_RS16530	COG1940	carbohydrate kinase activity
HV345_RS16535	COG0647	UMP catabolic process
HV345_RS16540	COG0367	asparagine synthase
HV345_RS16580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV345_RS16590	COG1702	phosphate starvation-inducible protein PhoH
HV345_RS16595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV345_RS16615	COG0765	amino acid transport
HV345_RS16620	COG0765	amino acid transport
HV345_RS16625	COG1126	abc transporter atp-binding protein
HV345_RS16635	COG2888	peptidyl-tyrosine sulfation
HV345_RS16650	COG1466	dna polymerase III delta subunit
HV345_RS16670	COG0799	negative regulation of ribosome biogenesis
HV345_RS16680	COG0768	penicillin binding
HV345_RS16685	COG0772	Belongs to the SEDS family
HV345_RS16690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV345_RS16695	COG1686	Belongs to the peptidase S11 family
HV345_RS16720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV345_RS16740	COG3069	C4-dicarboxylate transmembrane transporter activity
HV345_RS16745	COG4565	transcriptional regulatory protein
HV345_RS16750	COG3290	protein histidine kinase activity
HV345_RS16755	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV345_RS16765	COG2301	Belongs to the HpcH HpaI aldolase family
HV345_RS16770	COG3051	citrate lyase alpha subunit
HV345_RS16785	COG0471	metal ion transport
HV345_RS16790	COG3719	Belongs to the RNase T2 family
HV345_RS16805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV345_RS16815	COG3634	alkyl hydroperoxide reductase activity
HV345_RS16825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV345_RS16830	COG0583	DNA-binding transcription factor activity
HV345_RS16835	COG3969	phosphoadenosine phosphosulfate
HV345_RS16840	COG1475	DNA binding
HV345_RS16845	COG0436	Aminotransferase
HV345_RS16850	COG0371	Dehydrogenase
HV345_RS16855	COG2879	small protein
HV345_RS16860	COG1966	Carbon starvation protein
HV345_RS16870	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS16875	COG1535	isochorismatase
HV345_RS16875	COG3433	isochorismatase activity
HV345_RS16880	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV345_RS16885	COG1169	isochorismate synthase
HV345_RS16890	COG4592	Periplasmic binding protein
HV345_RS16900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV345_RS16905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV345_RS16910	COG1120	ATPase activity
HV345_RS16915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV345_RS16915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV345_RS16920	COG3251	PFAM MbtH domain protein
HV345_RS16925	COG2382	esterase
HV345_RS16930	COG4771	TonB-dependent receptor
HV345_RS16940	COG1879	ABC-type sugar transport system periplasmic component
HV345_RS16950	COG1129	ABC transporter
HV345_RS16955	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV345_RS16960	COG2390	Transcriptional regulator
HV345_RS16965	COG3959	Transketolase, thiamine diphosphate binding domain
HV345_RS16970	COG3958	Transketolase
HV345_RS16980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV345_RS17015	COG2315	Protein conserved in bacteria
HV345_RS17025	COG0668	transmembrane transport
HV345_RS17045	COG2211	Major facilitator Superfamily
HV345_RS17050	COG1113	amino acid transport
HV345_RS17070	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS17095	COG3005	denitrification pathway
HV345_RS17100	COG0745	RESPONSE REGULATOR receiver
HV345_RS17105	COG1879	ABC-type sugar transport system periplasmic component
HV345_RS17110	COG0784	Response regulator, receiver
HV345_RS17110	COG2198	Histidine kinase
HV345_RS17110	COG2205	protein histidine kinase activity
HV345_RS17175	COG2501	S4 domain
HV345_RS17180	COG1988	membrane-bound metal-dependent
HV345_RS17190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV345_RS17200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV345_RS17205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV345_RS17215	COG2011	ABC-type metal ion transport system permease component
HV345_RS17235	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV345_RS17240	COG4181	ATPase activity
HV345_RS17245	COG2755	lipolytic protein G-D-S-L family
HV345_RS17250	COG0300	oxidoreductase activity
HV345_RS17255	COG3118	belongs to the thioredoxin family
HV345_RS17260	COG0390	transport system, permease component
HV345_RS17265	COG4619	ABC transporter
HV345_RS17270	COG0330	HflC and HflK could
HV345_RS17275	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV345_RS17295	COG4771	TonB-dependent receptor
HV345_RS17300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV345_RS17310	COG3721	Heme iron utilization protein
HV345_RS17335	COG3735	TraB family
HV345_RS17340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV345_RS17350	COG2223	nitrite transmembrane transporter activity
HV345_RS17355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV345_RS17355	COG4651	solute:proton antiporter activity
HV345_RS17360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS17405	COG2832	Protein of unknown function (DUF454)
HV345_RS17410	COG3923	Primosomal replication protein n
HV345_RS17420	COG1196	nuclear chromosome segregation
HV345_RS17420	COG3264	Mechanosensitive ion channel
HV345_RS17425	COG1309	transcriptional regulator
HV345_RS17430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV345_RS17435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV345_RS17450	COG0110	maltose O-acetyltransferase activity
HV345_RS17470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV345_RS17475	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV345_RS17480	COG2364	Membrane
HV345_RS17485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV345_RS17505	COG3695	enzyme binding
HV345_RS17510	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV345_RS17515	COG1946	Acyl-CoA thioesterase
HV345_RS17520	COG0004	ammonium transporteR
HV345_RS17525	COG0347	Belongs to the P(II) protein family
HV345_RS17530	COG1132	(ABC) transporter
HV345_RS17535	COG1132	(ABC) transporter
HV345_RS17540	COG1522	sequence-specific DNA binding
HV345_RS17555	COG4533	DNA binding
HV345_RS17565	COG0824	Thioesterase
HV345_RS17570	COG1555	photosystem II stabilization
HV345_RS17575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV345_RS17580	COG0776	regulation of translation
HV345_RS17585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV345_RS17605	COG0271	Belongs to the BolA IbaG family
HV345_RS17610	COG3056	Lipoprotein
HV345_RS17615	COG2223	nitrite transmembrane transporter activity
HV345_RS17620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV345_RS17625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV345_RS17630	COG1845	cytochrome c oxidase, subunit III
HV345_RS17635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV345_RS17660	COG2814	Major facilitator Superfamily
HV345_RS17695	COG0142	geranyltranstransferase activity
HV345_RS17705	COG0667	Aldo Keto reductase
HV345_RS17710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV345_RS17715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV345_RS17730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV345_RS17730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV345_RS17740	COG4238	major outer membrane lipoprotein
HV345_RS17760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV345_RS17765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV345_RS17770	COG1862	Preprotein translocase
HV345_RS17780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV345_RS17790	COG0450	alkyl hydroperoxide reductase
HV345_RS17805	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV345_RS17815	COG1335	isochorismatase
HV345_RS17820	COG0583	DNA-binding transcription factor activity
HV345_RS17825	COG0366	Alpha amylase catalytic
HV345_RS17840	COG5002	protein histidine kinase activity
HV345_RS17850	COG0420	3'-5' exonuclease activity
HV345_RS17855	COG0419	ATPase involved in DNA repair
HV345_RS17860	COG2814	Major facilitator Superfamily
HV345_RS17865	COG1940	carbohydrate kinase activity
HV345_RS17880	COG4126	flavin adenine dinucleotide binding
HV345_RS17900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV345_RS17905	COG3706	GGDEF domain
HV345_RS17915	COG1785	Belongs to the alkaline phosphatase family
HV345_RS17930	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV345_RS17950	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV345_RS17955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV345_RS17960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV345_RS17965	COG3468	outer membrane autotransporter barrel domain protein
HV345_RS17970	COG0113	porphobilinogen synthase activity
HV345_RS17975	COG2175	clavaminate synthase activity
HV345_RS17980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV345_RS17985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV345_RS17990	COG4521	taurine ABC transporter
HV345_RS18005	COG2271	Major facilitator Superfamily
HV345_RS18010	COG1840	ABC-type Fe3 transport system, periplasmic component
HV345_RS18020	COG3842	ATPase activity
HV345_RS18025	COG2040	homocysteine
HV345_RS18030	COG0833	amino acid
HV345_RS18035	COG2814	Major facilitator Superfamily
HV345_RS18070	COG1414	Transcriptional regulator
HV345_RS18130	COG3210	domain, Protein
HV345_RS18145	COG1609	Transcriptional regulator
HV345_RS18170	COG2079	MmgE PrpD family protein
HV345_RS18175	COG0372	Belongs to the citrate synthase family
HV345_RS18185	COG3829	transcription factor binding
HV345_RS18195	COG1280	lysine exporter protein (LysE YggA)
HV345_RS18200	COG3706	GGDEF domain
HV345_RS18205	COG0348	domain, Protein
HV345_RS18230	COG3039	Transposase
HV345_RS18280	COG3344	reverse transcriptase
HV345_RS18290	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS18305	COG0840	transmembrane signaling receptor activity
HV345_RS18355	COG1294	oxidase, subunit
HV345_RS18380	COG3596	GTP binding
HV345_RS18390	COG2378	regulation of single-species biofilm formation
HV345_RS18400	COG2378	regulation of single-species biofilm formation
HV345_RS18420	COG2003	Belongs to the UPF0758 family
HV345_RS18490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV345_RS18500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV345_RS18525	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV345_RS18545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HV345_RS18550	COG1191	sigma factor activity
HV345_RS18575	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV345_RS18580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV345_RS18595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV345_RS18600	COG4786	Flagellar basal body rod
HV345_RS18600	COG1256	bacterial-type flagellum assembly
HV345_RS18620	COG4786	Flagellar basal body rod
HV345_RS18625	COG4787	bacterial-type flagellum-dependent cell motility
HV345_RS18640	COG1558	bacterial-type flagellum-dependent cell motility
HV345_RS18685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV345_RS18705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV345_RS18715	COG1677	Flagellar hook-basal body complex protein FliE
HV345_RS18740	COG1987	bacterial-type flagellum assembly
HV345_RS18745	COG1684	flagellar biosynthetic protein fliR
HV345_RS18765	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS18775	COG3034	peptidoglycan biosynthetic process
HV345_RS18780	COG0121	glutamine amidotransferase
HV345_RS18790	COG1960	acyl-CoA dehydrogenase activity
HV345_RS18795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV345_RS18805	COG2200	EAL domain
HV345_RS18820	COG3539	Fimbrial protein
HV345_RS18830	COG3121	Chaperone
HV345_RS18835	COG3188	usher protein
HV345_RS18845	COG3539	Fimbrial protein
HV345_RS18865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV345_RS18875	COG2226	methyltransferase
HV345_RS18885	COG1388	LysM domain
HV345_RS18885	COG0741	lytic transglycosylase activity
HV345_RS18890	COG2226	methyltransferase
HV345_RS18900	COG2814	Major facilitator Superfamily
HV345_RS18905	COG0583	DNA-binding transcription factor activity
HV345_RS18940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV345_RS18950	COG2011	ABC-type metal ion transport system permease component
HV345_RS18955	COG1464	Belongs to the NlpA lipoprotein family
HV345_RS18965	COG1720	tRNA m6t6A37 methyltransferase activity
HV345_RS18975	COG0791	NLP P60 protein
HV345_RS18980	COG3015	lipoprotein NlpE involved in copper resistance
HV345_RS18985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV345_RS19000	COG4568	rho-dependent transcription termination
HV345_RS19010	COG0346	lactoylglutathione lyase activity
HV345_RS19050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV345_RS19055	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV345_RS19070	COG0575	Belongs to the CDS family
HV345_RS19080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV345_RS19125	COG3835	regulator
HV345_RS19150	COG2860	membrane
HV345_RS19175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV345_RS19180	COG1120	ATPase activity
HV345_RS19185	COG4774	siderophore transport
HV345_RS19190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV345_RS19195	COG1643	Atp-dependent helicase
HV345_RS19200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV345_RS19220	COG0617	tRNA 3'-terminal CCA addition
HV345_RS19225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV345_RS19245	COG0726	polysaccharide deacetylase
HV345_RS19250	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS19255	COG0842	Transport permease protein
HV345_RS19260	COG1131	(ABC) transporter
HV345_RS19265	COG0288	reversible hydration of carbon dioxide
HV345_RS19270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV345_RS19275	COG4993	Dehydrogenase
HV345_RS19310	COG3064	Membrane
HV345_RS19325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV345_RS19330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV345_RS19335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV345_RS19350	COG2211	Major facilitator Superfamily
HV345_RS19355	COG3940	Belongs to the glycosyl hydrolase 43 family
HV345_RS19360	COG3725	Membrane protein required for beta-lactamase induction
HV345_RS19375	COG4969	Belongs to the N-Me-Phe pilin family
HV345_RS19380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV345_RS19385	COG1459	type II secretion system
HV345_RS19395	COG0237	dephospho-CoA kinase activity
HV345_RS19410	COG0494	nUDIX hydrolase
HV345_RS19430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV345_RS19435	COG0849	cell division
HV345_RS19445	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV345_RS19460	COG0772	Belongs to the SEDS family
HV345_RS19465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV345_RS19475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV345_RS19480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV345_RS19485	COG0768	penicillin binding
HV345_RS19515	COG0028	Belongs to the TPP enzyme family
HV345_RS19550	COG2814	Major facilitator Superfamily
HV345_RS19570	COG1178	ABC-type Fe3 transport system permease component
HV345_RS19580	COG0586	Pfam SNARE associated Golgi protein
HV345_RS19600	COG0235	Class ii aldolase
HV345_RS19610	COG0417	DNA replication proofreading
HV345_RS19620	COG0564	pseudouridine synthase activity
HV345_RS19680	COG2271	Major facilitator Superfamily
HV345_RS19690	COG0644	oxidoreductase
HV345_RS19740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV345_RS19745	COG0505	Belongs to the CarA family
HV345_RS19755	COG1609	Transcriptional regulator
HV345_RS19770	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS19770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS19775	COG3715	PTS system
HV345_RS19780	COG3716	PTS system mannose fructose sorbose family IID component
HV345_RS19790	COG2140	Oxalate decarboxylase
HV345_RS19805	COG1047	Peptidyl-prolyl cis-trans
HV345_RS19820	COG0196	riboflavin kinase activity
HV345_RS19845	COG0583	DNA-binding transcription factor activity
HV345_RS19865	COG0641	radical SAM
HV345_RS19870	COG3119	arylsulfatase activity
HV345_RS19905	COG0443	Heat shock 70 kDa protein
HV345_RS19910	COG1584	GPR1 FUN34 yaaH family protein
HV345_RS19920	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV345_RS19930	COG1115	amino acid carrier protein
HV345_RS19940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV345_RS19950	COG0460	homoserine dehydrogenase
HV345_RS19950	COG0527	aspartate kinase activity
HV345_RS19960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV345_RS19970	COG0745	RESPONSE REGULATOR receiver
HV345_RS19975	COG4452	Inner membrane protein CreD
HV345_RS19980	COG2205	protein histidine kinase activity
HV345_RS19985	COG0745	RESPONSE REGULATOR receiver
HV345_RS19990	COG3045	CreA protein
HV345_RS19995	COG2207	Transcriptional regulator
HV345_RS19995	COG3708	Transcriptional regulator
HV345_RS20020	COG0741	lytic transglycosylase activity
HV345_RS20025	COG0488	(ABC) transporter
HV345_RS20040	COG0560	Phosphoserine phosphatase
HV345_RS20045	COG3726	membrane protein affecting hemolysin expression
HV345_RS20075	COG1328	CTP reductase activity
HV345_RS20080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV345_RS20085	COG0084	hydrolase, TatD family'
HV345_RS20090	COG4667	esterase of the alpha-beta hydrolase superfamily
HV345_RS20095	COG5487	UPF0391 membrane protein
HV345_RS20100	COG2823	Periplasmic or secreted lipoprotein
HV345_RS20110	COG1011	Hydrolase
HV345_RS20115	COG0456	acetyltransferase
HV345_RS20120	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV345_RS20150	COG3706	GGDEF domain
HV345_RS20155	COG4114	ferric iron reductase
HV345_RS20160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV345_RS20165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV345_RS20170	COG2197	response regulator
HV345_RS20175	COG2197	response regulator
HV345_RS20180	COG2966	Psort location CytoplasmicMembrane, score
HV345_RS20195	COG1484	DNA-dependent DNA replication
HV345_RS20215	COG1063	alcohol dehydrogenase
HV345_RS20220	COG1802	Transcriptional regulator
HV345_RS20225	COG2271	Major facilitator Superfamily
HV345_RS20235	COG0840	transmembrane signaling receptor activity
HV345_RS20240	COG1966	Carbon starvation protein
HV345_RS20245	COG2879	small protein
HV345_RS20250	COG0523	cobalamin synthesis protein
HV345_RS20280	COG0732	type I restriction modification DNA specificity domain
HV345_RS20295	COG5457	Domain of unknown function (DUF1127)
HV345_RS20300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV345_RS20305	COG5464	transposase or invertase
HV345_RS20310	COG2207	Transcriptional regulator
HV345_RS20310	COG1917	Cupin 2, conserved barrel domain protein
HV345_RS20325	COG0626	cystathionine gamma-synthase activity
HV345_RS20330	COG1301	dicarboxylic acid transport
HV345_RS20335	COG0583	DNA-binding transcription factor activity
HV345_RS20340	COG2733	membrane
HV345_RS20345	COG0477	Major facilitator Superfamily
HV345_RS20355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV345_RS20365	COG2186	Transcriptional regulator
HV345_RS20370	COG0246	Mannitol dehydrogenase
HV345_RS20380	COG2610	gluconate transmembrane transporter activity
HV345_RS20385	COG1556	Lactate utilization protein
HV345_RS20390	COG1139	Iron-sulfur cluster binding protein
HV345_RS20395	COG0247	lactate metabolic process
HV345_RS20400	COG1620	l-lactate permease
HV345_RS20485	COG2003	Belongs to the UPF0758 family
HV345_RS20520	COG1216	Glycosyl transferase, family 2
HV345_RS20555	COG1196	nuclear chromosome segregation
HV345_RS20560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV345_RS20570	COG0582	viral genome integration into host DNA
HV345_RS20580	COG1064	alcohol dehydrogenase
HV345_RS20585	COG3265	gluconokinase activity
HV345_RS20590	COG1063	alcohol dehydrogenase
HV345_RS20595	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS20600	COG2610	gluconate transmembrane transporter activity
HV345_RS20605	COG1609	Transcriptional regulator
HV345_RS20610	COG0433	COG0433 Predicted ATPase
HV345_RS20615	COG0795	lipopolysaccharide-transporting ATPase activity
HV345_RS20620	COG0795	lipopolysaccharide-transporting ATPase activity
HV345_RS20630	COG2927	DNA polymerase III (CHI subunit)
HV345_RS20635	COG0525	valine-tRNA ligase activity
HV345_RS20670	COG2731	YhcH YjgK YiaL family protein
HV345_RS20685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV345_RS20690	COG1288	antiporter activity
HV345_RS20695	COG1438	arginine binding
HV345_RS20745	COG1263	PTS System
HV345_RS20745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV345_RS20750	COG0366	Alpha amylase catalytic
HV345_RS20765	COG3711	transcriptional antiterminator
HV345_RS20765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS20780	COG3964	amidohydrolase
HV345_RS20815	COG0312	modulator of DNA gyrase
HV345_RS20825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV345_RS20835	COG1486	melibiose metabolic process
HV345_RS20840	COG0517	IMP dehydrogenase activity
HV345_RS20840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV345_RS20845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV345_RS20855	COG0840	transmembrane signaling receptor activity
HV345_RS20865	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV345_RS20870	COG1129	ABC transporter
HV345_RS20875	COG1879	ABC-type sugar transport system periplasmic component
HV345_RS20885	COG3391	amine dehydrogenase activity
HV345_RS20890	COG4771	TonB-dependent receptor
HV345_RS20895	COG2105	PFAM AIG2 family protein
HV345_RS20900	COG2911	Protein conserved in bacteria
HV345_RS20905	COG0729	surface antigen
HV345_RS20915	COG1253	flavin adenine dinucleotide binding
HV345_RS20925	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV345_RS20930	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV345_RS20940	COG1733	regulation of RNA biosynthetic process
HV345_RS20945	COG0702	epimerase
HV345_RS20955	COG0697	spore germination
HV345_RS20960	COG0840	transmembrane signaling receptor activity
HV345_RS20970	COG1113	amino acid transport
HV345_RS20975	COG0545	Peptidyl-prolyl cis-trans isomerase
HV345_RS20980	COG3061	Opacity-associated protein A
HV345_RS20995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV345_RS21010	COG0730	response to heat
HV345_RS21060	COG1073	alpha beta
HV345_RS21065	COG3650	response to hydrogen peroxide
HV345_RS21075	COG1960	acyl-CoA dehydrogenase activity
HV345_RS21080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV345_RS21085	COG0557	exoribonuclease II activity
HV345_RS21100	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV345_RS21105	COG0330	HflC and HflK could
HV345_RS21110	COG0330	HflC and HflK could
HV345_RS21115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV345_RS21120	COG1923	regulation of RNA biosynthetic process
HV345_RS21135	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV345_RS21140	COG0802	atpase or kinase
HV345_RS21145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV345_RS21145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV345_RS21150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV345_RS21185	COG1511	domain protein
HV345_RS21185	COG3264	Mechanosensitive ion channel
HV345_RS21200	COG1053	succinate dehydrogenase
HV345_RS21205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV345_RS21260	COG1509	lysine 2,3-aminomutase activity
HV345_RS21285	COG0531	amino acid
HV345_RS21290	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV345_RS21295	COG1027	Aspartate ammonia-lyase
HV345_RS21300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV345_RS21315	COG1309	transcriptional regulator
HV345_RS21350	COG3290	protein histidine kinase activity
HV345_RS21355	COG4565	transcriptional regulatory protein
HV345_RS21365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV345_RS21370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS21370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV345_RS21375	COG3647	Membrane
HV345_RS21385	COG2211	Major facilitator Superfamily
HV345_RS21390	COG1486	melibiose metabolic process
HV345_RS21395	COG2169	Transcriptional regulator
HV345_RS21400	COG1982	Orn Lys Arg decarboxylase major
HV345_RS21405	COG2207	Transcriptional regulator
HV345_RS21410	COG0531	amino acid
HV345_RS21455	COG2824	Alkylphosphonate utilization operon protein PhnA
HV345_RS21460	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV345_RS21465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV345_RS21470	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV345_RS21475	COG3639	organic phosphonate transmembrane transporter activity
HV345_RS21480	COG2188	Transcriptional regulator
HV345_RS21485	COG3624	Phosphonate C-P lyase system protein PhnG
HV345_RS21490	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV345_RS21495	COG3626	phosphonate metabolism
HV345_RS21500	COG3627	carbon phosphorus lyase activity
HV345_RS21505	COG4107	phosphonate C-P lyase system protein PhnK
HV345_RS21510	COG4778	phosphonate C-P lyase system protein PhnL
HV345_RS21515	COG3454	Phosphonate metabolism
HV345_RS21520	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV345_RS21525	COG0456	acetyltransferase
HV345_RS21530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV345_RS21545	COG1129	ABC transporter
HV345_RS21550	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV345_RS21575	COG0745	RESPONSE REGULATOR receiver
HV345_RS21585	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV345_RS21590	COG1301	dicarboxylic acid transport
HV345_RS21595	COG4235	cytochrome complex assembly
HV345_RS21600	COG3088	subunit of a heme lyase
HV345_RS21620	COG3301	Polysulphide reductase, NrfD
HV345_RS21625	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS21630	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV345_RS21645	COG3162	membrane
HV345_RS21655	COG1346	cytolysis
HV345_RS21660	COG1380	Effector of murein hydrolase LrgA
HV345_RS21665	COG0583	DNA-binding transcription factor activity
HV345_RS21670	COG0025	NhaP-type Na H and K H
HV345_RS21675	COG2252	PERMEase
HV345_RS21680	COG0789	Transcriptional regulator
HV345_RS21690	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV345_RS21705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV345_RS21760	COG0210	DNA helicase
HV345_RS21785	COG0629	single-stranded DNA binding
HV345_RS21790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV345_RS21795	COG2315	Protein conserved in bacteria
HV345_RS21800	COG3700	Belongs to the class B bacterial acid phosphatase family
HV345_RS21805	COG1448	Aminotransferase
HV345_RS21815	COG0305	Participates in initiation and elongation during chromosome replication
HV345_RS21830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV345_RS21840	COG0735	belongs to the Fur family
HV345_RS21845	COG3237	CsbD-like
HV345_RS21850	COG0534	Mate efflux family protein
HV345_RS21860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV345_RS21895	COG2182	Extracellular solute-binding protein
HV345_RS21910	COG3223	Belongs to the PsiE family
HV345_RS21920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV345_RS21945	COG0527	aspartate kinase activity
HV345_RS21960	COG1187	pseudouridine synthase activity
HV345_RS21965	COG4977	sequence-specific DNA binding
HV345_RS21985	COG1410	methionine synthase
HV345_RS21985	COG0646	methionine synthase
HV345_RS22005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV345_RS22035	COG0151	Belongs to the GarS family
HV345_RS22045	COG4191	Histidine kinase
HV345_RS22100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV345_RS22105	COG2104	thiamine diphosphate biosynthetic process
HV345_RS22120	COG1278	Cold shock
HV345_RS22130	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV345_RS22165	COG0250	Participates in transcription elongation, termination and antitermination
HV345_RS22210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV345_RS22270	COG0583	DNA-binding transcription factor activity
HV345_RS22275	COG3979	chitinase
HV345_RS22310	COG2207	Transcriptional regulator
HV345_RS22315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS22320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV345_RS22325	COG1882	Formate acetyltransferase
HV345_RS22330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS22335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS22340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS22340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS22340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV345_RS22350	COG0371	Dehydrogenase
HV345_RS22360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV345_RS22375	COG0737	Belongs to the 5'-nucleotidase family
HV345_RS22385	COG0527	aspartate kinase activity
HV345_RS22385	COG0460	homoserine dehydrogenase
HV345_RS22390	COG0626	cystathionine gamma-synthase activity
HV345_RS22400	COG2211	Major facilitator Superfamily
HV345_RS22415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV345_RS22420	COG1609	Transcriptional regulator
HV345_RS22425	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV345_RS22440	COG1575	Belongs to the MenA family. Type 1 subfamily
HV345_RS22450	COG3074	FtsZ-dependent cytokinesis
HV345_RS22455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV345_RS22465	COG1494	fructose-1,6-bisphosphatase
HV345_RS22475	COG3152	Membrane
HV345_RS22500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV345_RS22560	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV345_RS22650	COG4695	Portal protein
HV345_RS22725	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV345_RS22730	COG3678	ATP-independent chaperone mediated protein folding
HV345_RS22735	COG0745	RESPONSE REGULATOR receiver
HV345_RS22740	COG2205	protein histidine kinase activity
HV345_RS22745	COG2271	Major facilitator Superfamily
HV345_RS22750	COG1082	Xylose isomerase domain protein TIM barrel
HV345_RS22755	COG2188	Transcriptional regulator
HV345_RS22760	COG2258	MOSC domain
HV345_RS22765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV345_RS22790	COG0738	Major facilitator superfamily
HV345_RS22795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV345_RS22795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS22795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS22800	COG0383	alpha-mannosidase activity
HV345_RS22805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS22810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS22845	COG1454	alcohol dehydrogenase
HV345_RS22865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV345_RS22875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS22880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS22880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV345_RS22885	COG1363	Peptidase, m42
HV345_RS22890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV345_RS22890	COG3711	transcriptional antiterminator
HV345_RS22910	COG0437	4 iron, 4 sulfur cluster binding
HV345_RS22915	COG2864	formate dehydrogenase
HV345_RS22930	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV345_RS22940	COG4680	protein conserved in bacteria
HV345_RS22945	COG5499	transcription regulator containing HTH domain
HV345_RS22950	COG0456	acetyltransferase
HV345_RS22955	COG1490	D-aminoacyl-tRNA deacylase activity
HV345_RS22965	COG1011	Hydrolase
HV345_RS22970	COG1349	DNA-binding transcription factor activity
HV345_RS22975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS22985	COG3684	Belongs to the aldolase LacD family
HV345_RS22995	COG2017	converts alpha-aldose to the beta-anomer
HV345_RS23000	COG1501	Belongs to the glycosyl hydrolase 31 family
HV345_RS23030	COG3852	Histidine kinase
HV345_RS23035	COG2204	response regulator
HV345_RS23045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV345_RS23070	COG0204	Acyl-transferase
HV345_RS23085	COG3084	Protein conserved in bacteria
HV345_RS23090	COG0746	molybdenum cofactor guanylyltransferase activity
HV345_RS23095	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV345_RS23135	COG1739	Uncharacterized protein family UPF0029
HV345_RS23155	COG1609	Transcriptional regulator
HV345_RS23160	COG1940	carbohydrate kinase activity
HV345_RS23170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV345_RS23185	COG0805	protein transport
HV345_RS23230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV345_RS23235	COG0583	DNA-binding transcription factor activity
HV345_RS23240	COG0697	spore germination
HV345_RS23245	COG0561	phosphatase activity
HV345_RS23250	COG2267	carboxylic ester hydrolase activity
HV345_RS23255	COG1280	lysine exporter protein (LysE YggA)
HV345_RS23260	COG1280	lysine exporter protein (LysE YggA)
HV345_RS23295	COG1011	Hydrolase
HV345_RS23340	COG2959	enzyme of heme biosynthesis
HV345_RS23345	COG3071	HemY protein
HV345_RS23390	COG2244	polysaccharide biosynthetic process
HV345_RS23395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV345_RS23400	COG0456	acetyltransferase
HV345_RS23405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV345_RS23420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV345_RS23425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV345_RS23435	COG3118	belongs to the thioredoxin family
HV345_RS23455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV345_RS23475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV345_RS23485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV345_RS23490	COG3978	acetolactate synthase activity
HV345_RS23510	COG3085	chromosome segregation
HV345_RS23550	COG2186	Transcriptional regulator
HV345_RS23555	COG0477	Major facilitator Superfamily
HV345_RS23560	COG1609	Transcriptional regulator
HV345_RS23565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV345_RS23570	COG1879	ABC-type sugar transport system periplasmic component
HV345_RS23575	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV345_RS23585	COG1869	D-ribose catabolic process
HV345_RS23610	COG1522	sequence-specific DNA binding
HV345_RS23615	COG0716	FMN binding
HV345_RS23630	COG3312	ion transport
HV345_RS23655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV345_RS23665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV345_RS23670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV345_RS23685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV345_RS23690	COG0573	inorganic phosphate transmembrane transporter activity
HV345_RS23695	COG0581	inorganic phosphate transmembrane transporter activity
HV345_RS23705	COG0704	Plays a role in the regulation of phosphate uptake
HV345_RS23725	COG3979	chitinase
HV345_RS23730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV345_RS23735	COG2252	PERMEase
HV345_RS23740	COG0431	NADPH-dependent FMN reductase
HV345_RS23745	COG2091	lysine biosynthetic process via aminoadipic acid
HV345_RS23780	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV345_RS23880	COG3436	PFAM IS66 Orf2 family protein
HV345_RS23885	COG4372	Transposase
HV345_RS23915	COG0071	Belongs to the small heat shock protein (HSP20) family
HV345_RS23920	COG0542	response to heat
HV345_RS23980	COG0501	Belongs to the peptidase M48B family
HV345_RS23985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV345_RS24055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV345_RS24060	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS24075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV345_RS24080	COG3118	belongs to the thioredoxin family
HV345_RS24085	COG1902	pentaerythritol trinitrate reductase activity
HV345_RS24090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HV345_RS24095	COG1028	Short-chain dehydrogenase reductase Sdr
HV345_RS24125	COG0659	secondary active sulfate transmembrane transporter activity
HV345_RS24130	COG0589	response to stress
HV345_RS24165	COG1136	(ABC) transporter
HV345_RS24180	COG1309	transcriptional regulator
HV345_RS24190	COG1342	Belongs to the UPF0251 family
HV345_RS24205	COG0783	Belongs to the Dps family
HV345_RS24210	COG0640	Transcriptional regulator
HV345_RS24215	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV345_RS24235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV345_RS24280	COG5001	Diguanylate cyclase
HV345_RS24290	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HV345_RS24305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV345_RS24345	COG3039	Transposase
HV345_RS24350	COG1528	Iron-storage protein
HV345_RS24360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV345_RS24375	COG0789	Transcriptional regulator
HV345_RS24385	COG2608	mercury ion transmembrane transporter activity
HV345_RS24390	COG2608	mercury ion transmembrane transporter activity
HV345_RS24395	COG0789	Transcriptional regulator
HV345_RS24465	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV345_RS24495	COG0739	heme binding
HV345_RS24505	COG2132	Multicopper oxidase
HV345_RS24510	COG3667	copper resistance
HV345_RS24515	COG2372	response to copper ion
HV345_RS24520	COG1276	copper resistance
HV345_RS24525	COG0745	RESPONSE REGULATOR receiver
HV345_RS24530	COG2205	protein histidine kinase activity
HV345_RS24550	COG3436	PFAM IS66 Orf2 family protein
HV345_RS24600	COG3039	Transposase
HV345_RS24625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV345_RS24630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV345_RS24645	COG3423	Transcriptional regulator
HV345_RS24805	COG2974	May be involved in recombination
HV345_RS24865	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS24930	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS24975	COG1199	ATP-dependent helicase activity
HV345_RS25115	COG5654	RES domain protein
HV345_RS25120	COG5642	Protein of unknown function (DUF2384)
HV345_RS25165	COG1192	Involved in chromosome partitioning
HV345_RS25220	COG0305	Participates in initiation and elongation during chromosome replication
HV345_RS25325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV345_RS25330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV345_RS25335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV345_RS25340	COG4772	TonB-dependent receptor
HV345_RS25345	COG3712	iron ion homeostasis
HV345_RS25350	COG1595	DNA-templated transcription, initiation
HV345_RS25380	COG0840	transmembrane signaling receptor activity
HV345_RS25395	COG2826	transposase and inactivated derivatives, IS30 family
HV345_RS25430	COG3039	Transposase
HV345_RS25605	COG0210	DNA helicase
HV345_RS25660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV345_RS25870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV345_RS25870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV345_RS25985	COG2223	nitrite transmembrane transporter activity
HV345_RS25995	COG1609	Transcriptional regulator
HV345_RS26010	COG3436	PFAM IS66 Orf2 family protein
HV345_RS26015	COG1120	ATPase activity