locus-tag class description HV352_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV352_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV352_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV352_RS00025 ENOG410667J hydrolase HV352_RS00030 ENOG4107WAP fad NAD(P)-binding domain HV352_RS00035 ENOG4105D99 atp gtp-binding protein HV352_RS00040 ENOG4105R2A (LipO)protein HV352_RS00045 ENOG4108ZNX Heat shock protein HV352_RS00050 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HV352_RS00065 ENOG4106DRA Inner membrane protein YidI HV352_RS00070 ENOG4105VG5 Membrane HV352_RS00075 ENOG4105JP4 Inner membrane protein yidG HV352_RS00080 ENOG4105C4X radical SAM domain protein HV352_RS00085 ENOG4105BZC d-serine deaminase HV352_RS00095 ENOG4105W8I Transcriptional regulator HV352_RS00105 ENOG4105E5M Multidrug resistance protein D HV352_RS00125 ENOG4105C7K acetolactate synthase HV352_RS00130 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV352_RS00135 ENOG4107FB0 transcriptional regulator DeoR family HV352_RS00145 ENOG4105EDR glucose galactose transporter HV352_RS00155 ENOG4108KX4 response regulator HV352_RS00160 ENOG4105BZU Histidine kinase HV352_RS00165 ENOG4105CXY transporter HV352_RS00170 ENOG4105CXY transporter HV352_RS00175 ENOG4108SAJ Protein of unknown function (DUF1198) HV352_RS00185 ENOG4105KDP XRE family HV352_RS00195 ENOG4105CS2 ec 3.2.1.21 HV352_RS00210 ENOG4105D01 (LipO)protein HV352_RS00215 ENOG4108UZ3 Transporter HV352_RS00225 ENOG4105CIS alcohol dehydrogenase HV352_RS00230 ENOG4105EJC lysr family transcriptional regulator HV352_RS00235 ENOG4106PHM regulatory protein HV352_RS00240 ENOG4108SQA Fimbrial HV352_RS00260 ENOG41086KC Transcriptional regulator HV352_RS00280 ENOG4105ISV protein with bipartite regulator domain HV352_RS00310 ENOG4105CT4 transporter HV352_RS00315 ENOG4105CJQ hydrolase, family 31 HV352_RS00320 ENOG4105ETD TRANSCRIPTIONal HV352_RS00325 ENOG4105DM4 PTS System HV352_RS00330 ENOG4108YRF PTS System HV352_RS00335 ENOG4105DM4 PTS System HV352_RS00340 ENOG4105D2N Aldolase HV352_RS00345 ENOG4105D2N Aldolase HV352_RS00355 ENOG4105JV1 AsmA family HV352_RS00360 ENOG4105C2W permease HV352_RS00365 ENOG4105D6U Sodium Glutamate Symporter HV352_RS00370 ENOG4105CB5 ATP-dependent DNA helicase recG HV352_RS00375 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV352_RS00380 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV352_RS00390 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HV352_RS00395 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HV352_RS00400 ENOG4105EN6 Membrane HV352_RS00405 ENOG4105DSJ YicC domain protein HV352_RS00410 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HV352_RS00425 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HV352_RS00430 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV352_RS00435 ENOG4105W5Q DNA repair protein (RadC HV352_RS00445 ENOG4105W0E 50S ribosomal protein L33 HV352_RS00450 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HV352_RS00455 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HV352_RS00460 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV352_RS00465 ENOG4105DKP glycosyl transferase, family 9 HV352_RS00470 ENOG4107RJ7 Glycosyl transferase (Group 1 HV352_RS00475 ENOG4107543 (lipo)polysaccharide HV352_RS00480 ENOG4106AH0 Glycosyl Transferase HV352_RS00485 ENOG4105X1N Glycosyl transferase family 8 HV352_RS00490 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HV352_RS00495 ENOG4108FRV O-antigen ligase HV352_RS00500 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV352_RS00505 ENOG4105XA0 heptosyltransferase ii HV352_RS00520 ENOG4108SEH involved in lipopolysaccharide biosynthesis HV352_RS00525 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV352_RS00530 ENOG4105CPQ Dehydrogenase HV352_RS00540 ENOG4105K64 Glycosyl transferase, family 2 HV352_RS00545 ENOG4105PXI polysaccharide deacetylase HV352_RS00550 ENOG41063SB peptidase HV352_RS00560 ENOG4107YZP Rhodanese domain protein HV352_RS00565 ENOG4105VW4 glutaredoxin 3 HV352_RS00570 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HV352_RS00575 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HV352_RS00580 ENOG4105D7W serine acetyltransferase HV352_RS00585 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV352_RS00590 ENOG4105D2S major facilitator superfamily HV352_RS00595 ENOG4105DMF Dehydrogenase HV352_RS00600 ENOG41073TP transcriptional regulator HV352_RS00605 ENOG4105DAA L-lactate HV352_RS00610 ENOG4108YYI Protein of unknown function (DUF2810) HV352_RS00620 ENOG4105E61 Mannitol repressor protein HV352_RS00630 ENOG4105CTS PTS system mannitol-specific HV352_RS00635 ENOG4105FP6 Protein of unknown function (DUF3302) HV352_RS00640 ENOG4105EFX secretion protein, HlyD family HV352_RS00645 ENOG4108U78 Glutathione S-transferase HV352_RS00655 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV352_RS00660 ENOG4105C0A alcohol dehydrogenase HV352_RS00665 ENOG4105C26 Dehydrogenase HV352_RS00670 ENOG4105KK7 inner membrane protein YiaW HV352_RS00675 ENOG4105EFX secretion protein, HlyD family HV352_RS00680 ENOG4108Q2M Transcriptional regulator HV352_RS00685 ENOG4105GNX MltA-interacting MipA family protein HV352_RS00690 ENOG4108XIB electron transport protein ysaA HV352_RS00695 ENOG4105JKW Valine--pyruvate aminotransferase HV352_RS00700 ENOG4107T9C Alpha amylase catalytic region HV352_RS00705 ENOG4108UR8 BAX protein HV352_RS00710 ENOG4105T16 Transcriptional regulator (AraC family) HV352_RS00715 ENOG4108HWW ABC transporter HV352_RS00725 ENOG4105DFW ABC transporter HV352_RS00735 ENOG4105CMG Carbohydrate kinase HV352_RS00740 ENOG410688U Inner membrane protein yiaB HV352_RS00745 ENOG4108Z12 YiaAB two helix domain-containing protein HV352_RS00750 ENOG4105MEV Acyl-transferase HV352_RS00765 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HV352_RS00780 ENOG4105MVF Transcriptional regulator HV352_RS00785 ENOG4106JH6 (LipO)protein HV352_RS00790 ENOG4105C5I Dehydrogenase HV352_RS00795 ENOG4105JHE Major Facilitator Superfamily HV352_RS00800 ENOG4105D7K pfkb domain protein HV352_RS00810 ENOG4108M60 Transcriptional regulator HV352_RS00815 ENOG4108ZG0 Ompa motb domain protein HV352_RS00820 ENOG4107QY8 reductase HV352_RS00825 ENOG4105HNP -acetyltransferase HV352_RS00830 ENOG4108R3E Dna-3-methyladenine glycosylase i HV352_RS00835 ENOG4105EAX Putative lipase HV352_RS00840 ENOG4105FCD Major Facilitator HV352_RS00845 ENOG4105DIJ Phosphoethanolamine transferase HV352_RS00865 ENOG4105DEF Extracellular solute-binding protein, family 5 HV352_RS00870 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV352_RS00875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV352_RS00880 ENOG4105C3U ABC transporter HV352_RS00885 ENOG4108JQ7 (ABC) transporter HV352_RS00890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV352_RS00895 ENOG4105C44 Serine transporter HV352_RS00900 ENOG4105C28 cystathionine HV352_RS00910 ENOG4105BZU Histidine kinase HV352_RS00915 ENOG4105CK2 sodium dicarboxylate symporter HV352_RS00920 ENOG4105CS0 peptidase HV352_RS00925 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HV352_RS00930 ENOG4105CMB EAL domain-containing protein HV352_RS00935 ENOG41066T0 asmA family HV352_RS00940 ENOG4105CSH Transporter HV352_RS00945 ENOG4107H3J ribonuclease HV352_RS00950 ENOG4105CBN LysR family transcriptional regulator HV352_RS00955 ENOG4105CHR reductase HV352_RS00960 ENOG4106S2D Transcriptional regulator HV352_RS00970 ENOG41068WN HV352_RS00985 ENOG4105CA0 peroxidase HV352_RS00995 ENOG4105DC8 reductase HV352_RS01000 ENOG4105D6S protein involved in catabolism of external DNA HV352_RS01005 ENOG4105DGW oligopeptidase A HV352_RS01015 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV352_RS01020 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HV352_RS01025 ENOG4107EDW L-fucose operon activator HV352_RS01035 ENOG4105CTS PTS system mannitol-specific HV352_RS01040 ENOG4105CHR reductase HV352_RS01050 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV352_RS01055 ENOG4105DUX Transporter HV352_RS01065 ENOG4108V6B universal stress protein B HV352_RS01070 ENOG4105CJ3 phosphate transporter HV352_RS01075 ENOG4105CBX hi0933 family HV352_RS01080 ENOG4105CJW magnesium transporter HV352_RS01085 ENOG4105D0S secretion protein (HlyD HV352_RS01090 ENOG4105CJ1 ABC, transporter HV352_RS01095 ENOG4105CMI transporter HV352_RS01100 ENOG4105MRR Transcriptional regulator (By similarity) HV352_RS01110 ENOG4105PY6 Phenolic acid decarboxylase HV352_RS01115 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HV352_RS01120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV352_RS01125 ENOG4105C2D reductase HV352_RS01160 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HV352_RS01210 ENOG4105DSF transport protein HV352_RS01215 ENOG4105F9N Major Facilitator Superfamily HV352_RS01220 ENOG4108W1V Lipoprotein HV352_RS01225 ENOG4105EX9 Membrane HV352_RS01240 ENOG4107FS9 Membrane HV352_RS01250 ENOG4105MG3 Membrane HV352_RS01255 ENOG4106H78 methyltransferase HV352_RS01260 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV352_RS01265 ENOG4105CAK Cell division ATP-binding protein ftsE HV352_RS01270 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV352_RS01285 ENOG4105U59 -acetyltransferase HV352_RS01290 ENOG4105CP9 extracellular ligand-binding receptor HV352_RS01295 ENOG4105C32 Amino acid ABC transporter (Permease) HV352_RS01300 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV352_RS01305 ENOG4105C0Z ABC transporter HV352_RS01310 ENOG4108IV0 ABC, transporter HV352_RS01320 ENOG4105BZ7 extracellular solute-binding protein family 1 HV352_RS01325 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV352_RS01340 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV352_RS01345 ENOG4105WC8 Conserved Protein HV352_RS01350 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV352_RS01360 ENOG4105WCN acetyltransferase HV352_RS01365 ENOG4105D9R oxidoreductase HV352_RS01370 ENOG4105C2I pirin domain protein HV352_RS01375 ENOG4105DIQ Transcriptional regulator HV352_RS01380 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV352_RS01385 ENOG4105C6Z Gluconate HV352_RS01390 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HV352_RS01395 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV352_RS01400 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV352_RS01405 ENOG4108IUM Glycogen debranching enzyme HV352_RS01415 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HV352_RS01420 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV352_RS01425 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV352_RS01430 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HV352_RS01435 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HV352_RS01440 ENOG4105E98 transcriptional regulator DeoR family HV352_RS01445 ENOG41061ZR Transcriptional regulator HV352_RS01450 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV352_RS01455 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV352_RS01460 ENOG4105C6Z Gluconate HV352_RS01465 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HV352_RS01470 ENOG4105MJ2 Competence protein HV352_RS01480 ENOG4105DNE Transposase HV352_RS01490 ENOG4105CE1 Ferrous iron transport protein b HV352_RS01495 ENOG4105XFK Ferrous iron transport protein A HV352_RS01500 ENOG4105BZM domain protein HV352_RS01505 ENOG4108RRZ Transcription elongation factor GreB HV352_RS01515 ENOG4105E0F Histidine kinase HV352_RS01520 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HV352_RS01525 ENOG4108MAJ Membrane HV352_RS01535 ENOG4105VEJ Heat shock protein HV352_RS01540 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV352_RS01545 ENOG4105DQY intracellular growth attenuator HV352_RS01550 ENOG4107RK2 ADP-ribose diphosphatase NudE HV352_RS01555 ENOG4108JQC penicillin-binding protein 1A HV352_RS01560 ENOG4108U1Q Pilus assembly protein HV352_RS01575 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HV352_RS01580 ENOG4105E4G Type IV pilus HV352_RS01585 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV352_RS01590 ENOG4105D49 3-dehydroquinate synthase HV352_RS01595 ENOG4105EGB membrane protein DamX HV352_RS01600 ENOG4105DFE Dna adenine methylase HV352_RS01605 ENOG4105DJV ribulose-phosphate 3-epimerase HV352_RS01610 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HV352_RS01615 ENOG4105C31 Tryptophanyl-tRNA synthetase HV352_RS01620 ENOG4105VYH HV352_RS01630 ENOG4107V9H nitrite transporter HV352_RS01635 ENOG4105WZK nitrite reductase NADPH small subunit HV352_RS01640 ENOG4107QZF nitrite reductase NADPH large subunit HV352_RS01650 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV352_RS01660 ENOG4105MZU cell filamentation protein HV352_RS01665 ENOG4105DDQ anthranilate synthase HV352_RS01670 ENOG4105C8Y Acetylornithine aminotransferase HV352_RS01675 ENOG410613R integral membrane protein, YccS YhfK family HV352_RS01680 ENOG4107RYR Transcriptional regulator, Crp Fnr family HV352_RS01685 ENOG4108UKZ OsmC family HV352_RS01690 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV352_RS01700 ENOG4105DNZ Alpha Beta Hydrolase HV352_RS01705 ENOG4105C5H ABC transporter HV352_RS01710 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HV352_RS01715 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV352_RS01720 ENOG4105VKU nucleicacid-binding protein HV352_RS01725 ENOG4108YZY peptidylprolyl cis-trans isomerase HV352_RS01730 ENOG4105VRX Protein slyX homolog HV352_RS01735 ENOG4108V1T peptidylprolyl cis-trans isomerase HV352_RS01740 ENOG4105WWK YheO domain protein HV352_RS01745 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HV352_RS01750 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV352_RS01755 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV352_RS01770 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV352_RS01780 ENOG4105W53 bacterioferritin-associated ferredoxin HV352_RS01785 ENOG4108UQY Iron-storage protein HV352_RS01800 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HV352_RS01805 ENOG4105R04 type II secretion system protein K HV352_RS01820 ENOG41069X0 general secretion pathway protein h HV352_RS01825 ENOG4108VAU general secretion pathway protein G HV352_RS01830 ENOG4105D7Q type ii secretion system HV352_RS01835 ENOG4107QHF type ii secretion system protein e HV352_RS01840 ENOG4105GVR general secretion pathway protein D HV352_RS01865 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HV352_RS01870 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HV352_RS01885 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HV352_RS01890 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HV352_RS01905 ENOG41083MP 50s ribosomal protein l29 HV352_RS01910 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HV352_RS01930 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HV352_RS01940 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HV352_RS01950 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HV352_RS01955 ENOG4105VPB 50S ribosomal protein L30 HV352_RS01960 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HV352_RS01965 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV352_RS01970 ENOG41067V7 50S ribosomal protein L36 HV352_RS01980 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HV352_RS02000 ENOG4105VTS DnaJ-like, subfamily C HV352_RS02005 ENOG4105W1Y Transcriptional regulator HV352_RS02010 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV352_RS02015 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HV352_RS02020 ENOG4105C1A potassium transporter peripheral membrane HV352_RS02035 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HV352_RS02040 ENOG4105C79 DNA protecting protein DprA HV352_RS02050 ENOG4108WI1 Dna topoisomerase HV352_RS02055 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV352_RS02060 ENOG4105E2X shikimate dehydrogenase HV352_RS02065 ENOG4105SG3 Protein of unknown function (DUF1488) HV352_RS02070 ENOG4108Z0R Transferase HV352_RS02110 ENOG4105CDA abc transporter atp-binding protein HV352_RS02115 ENOG4105DRP amino acid AbC transporter HV352_RS02120 ENOG4105EZ7 amino acid ABC transporter HV352_RS02130 ENOG4105XCM membrane LIPOPROTEIN HV352_RS02135 ENOG4105BZS acriflavin resistance protein HV352_RS02140 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV352_RS02145 ENOG4108XG4 DNA-binding transcriptional regulator HV352_RS02150 ENOG41061ME transport protein HV352_RS02155 ENOG4105CEC DNA methylase N-4 N-6 HV352_RS02165 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV352_RS02175 ENOG4108IA2 Sodium pantothenate symporter HV352_RS02180 ENOG4105RG0 Membrane HV352_RS02185 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV352_RS02190 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV352_RS02205 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV352_RS02210 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV352_RS02220 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV352_RS02225 ENOG4105VQ7 Rod shape-determining protein MreD HV352_RS02235 ENOG4105C03 ribonuclease HV352_RS02240 ENOG4105QD6 exported protein HV352_RS02245 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV352_RS02250 ENOG4105CR8 Transcriptional regulator HV352_RS02255 ENOG4105ZQC membrane protein AaeX HV352_RS02260 ENOG4105Y49 secretion protein, HlyD family HV352_RS02265 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HV352_RS02270 ENOG4105UNR (Barnase) inhibitor HV352_RS02280 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV352_RS02290 ENOG4105C0H protease HV352_RS02295 ENOG4105C0H protease HV352_RS02300 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV352_RS02305 ENOG4105D6Z AFG1 family ATPase HV352_RS02310 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HV352_RS02320 ENOG4107MKT Stringent starvation protein a HV352_RS02325 ENOG4105KB2 stringent starvation protein b HV352_RS02330 ENOG4105CEE C4-dicarboxylate transporter HV352_RS02340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV352_RS02345 ENOG4105JHE Major Facilitator Superfamily HV352_RS02355 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HV352_RS02360 ENOG4108R66 Conserved Protein HV352_RS02365 ENOG4105DZC cytosine deaminase HV352_RS02370 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV352_RS02375 ENOG4105BZ8 glutamate synthase HV352_RS02380 ENOG4105CBC glutamate synthase HV352_RS02385 ENOG4105N5T Radical SAM Protein HV352_RS02390 ENOG4105BZU Histidine kinase HV352_RS02395 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV352_RS02400 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HV352_RS02405 ENOG41080Z8 PHOSPHOCARRIER protein HV352_RS02410 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HV352_RS02415 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV352_RS02420 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV352_RS02425 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV352_RS02430 ENOG4108IUZ ABC transporter HV352_RS02435 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV352_RS02440 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV352_RS02445 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HV352_RS02450 ENOG4105C2X Arabinose 5-phosphate isomerase HV352_RS02455 ENOG4105FEU K -dependent Na -Ca exchanger HV352_RS02460 ENOG4105DHJ ABC, transporter HV352_RS02465 ENOG4105CY3 ABC transporter, permease HV352_RS02470 ENOG4107PE3 Mammalian cell entry related domain protein HV352_RS02475 ENOG4105E3I toluene tolerance HV352_RS02480 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV352_RS02485 ENOG4105VFK BolA family HV352_RS02495 ENOG4105HVQ Regulatory factor of maltose metabolism HV352_RS02500 ENOG4105EAH synthase HV352_RS02505 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HV352_RS02510 ENOG4105K46 50S ribosomal protein l27 HV352_RS02515 ENOG4105QYV Membrane HV352_RS02520 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HV352_RS02525 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV352_RS02530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV352_RS02535 ENOG4105HBR Rna-binding protein HV352_RS02545 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV352_RS02550 ENOG4105EEI dihydropteroate synthase HV352_RS02555 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HV352_RS02560 ENOG4105CEE C4-dicarboxylate transporter HV352_RS02565 ENOG4105DYB Isoaspartyl dipeptidase HV352_RS02570 ENOG4107YNJ LysR family Transcriptional regulator HV352_RS02575 ENOG4105NTZ Preprotein translocase subunit SecG HV352_RS02585 ENOG4105CDH Citrulline--aspartate ligase HV352_RS02595 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HV352_RS02600 ENOG4105CHV Transcription elongation factor NusA HV352_RS02605 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HV352_RS02610 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HV352_RS02640 ENOG4105C1J atp-dependent rna helicase HV352_RS02645 ENOG4105CIC tryptophan-specific transport protein HV352_RS02650 ENOG4105DEN Luciferase family HV352_RS02670 ENOG4108YYD acetyltransferase HV352_RS02675 ENOG41082IR Excinuclease ABC C subunit domain protein HV352_RS02680 ENOG4108ZPB UPF0306 protein HV352_RS02685 ENOG4105K4T epimerase HV352_RS02690 ENOG4105W4M Transport-associated protein HV352_RS02695 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HV352_RS02705 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HV352_RS02710 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV352_RS02715 ENOG4106HBN Galactosamine-6-phosphate isomerase HV352_RS02725 ENOG4105ETZ PTS System HV352_RS02730 ENOG4108UZY PTS System HV352_RS02735 ENOG4105D2N Aldolase HV352_RS02740 ENOG4105E70 isomerase HV352_RS02745 ENOG4105CE4 GlcNAc 6-P deacetylase HV352_RS02750 ENOG4108YTN IIa component HV352_RS02755 ENOG4105F3R pts system mannose fructose sorbose family iid HV352_RS02765 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HV352_RS02770 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HV352_RS02775 ENOG4105E98 transcriptional regulator DeoR family HV352_RS02780 ENOG4105CTX dehydratase HV352_RS02785 ENOG4105DJB Major Facilitator Superfamily HV352_RS02790 ENOG4105CNV Aldolase HV352_RS02795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV352_RS02800 ENOG4105BZW Glycerate kinase HV352_RS02810 ENOG410811B TRANSCRIPTIONal HV352_RS02815 ENOG4105C7B Threonine dehydratase HV352_RS02820 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HV352_RS02830 ENOG4105C6N Formate acetyltransferase HV352_RS02835 ENOG4105KME endoribonuclease L-psp HV352_RS02840 ENOG4105EJQ L-serine dehydratase HV352_RS02845 ENOG4105C44 Serine transporter HV352_RS02855 ENOG4106D80 Uncharacterized protein YhaL HV352_RS02860 ENOG4108CNN domain protein HV352_RS02865 ENOG4105CWB LysR family transcriptional Regulator HV352_RS02870 ENOG4105KAF membrAne HV352_RS02875 ENOG4105CHF Glutathione S-transferase HV352_RS02880 ENOG4108VBZ doxx family HV352_RS02885 ENOG4105YJD HV352_RS02890 ENOG41090KG Inner membrane protein YqjE HV352_RS02895 ENOG4105NE1 Conserved Protein HV352_RS02900 ENOG4105WAY exported protein HV352_RS02910 ENOG4106W5V Membrane HV352_RS02915 ENOG4107YCY Transcriptional regulator HV352_RS02920 ENOG4105DPW Major facilitator superfamily MFS_1 HV352_RS02930 ENOG4105CTX dehydratase HV352_RS02935 ENOG4105P66 Membrane HV352_RS02945 ENOG4105DU1 integral membrane protein, terc HV352_RS02950 ENOG4105EE0 oxidoreductase HV352_RS02955 ENOG4108VKG metal-dependent hydrolase HV352_RS02960 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV352_RS02965 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV352_RS02990 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HV352_RS02995 ENOG4105DRS transport system, permease HV352_RS03005 ENOG4105HY2 Glycosidase related protein HV352_RS03010 ENOG4105E5D amino acid HV352_RS03015 ENOG4105FK9 beta-D-galactosidase beta subunit HV352_RS03020 ENOG4105CNT hydrolase family 2 HV352_RS03025 ENOG4105CQ4 Transcriptional regulator HV352_RS03030 ENOG4108Y51 tRNA-binding protein HV352_RS03035 ENOG4105C8Y Acetylornithine aminotransferase HV352_RS03040 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV352_RS03045 ENOG4105NTW Transcriptional regulator HV352_RS03050 ENOG4105Q26 Siderophore-interacting protein HV352_RS03060 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV352_RS03105 ENOG4105YCI dehydratase medium subunit HV352_RS03110 ENOG4108ZFT Dehydratase small subunit HV352_RS03115 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV352_RS03120 ENOG4105V2F Uncharacterized protein yoac HV352_RS03155 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV352_RS03160 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV352_RS03170 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV352_RS03175 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HV352_RS03180 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV352_RS03185 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HV352_RS03190 ENOG4105CQM Urea amidohydrolase subunit alpha HV352_RS03195 ENOG4105KI2 Urea amidohydrolase subunit beta HV352_RS03200 ENOG4108YZ9 Urea amidohydrolase subunit gamma HV352_RS03205 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV352_RS03210 ENOG4107QPK )-transporter HV352_RS03215 ENOG4107GFK fumarate HV352_RS03220 ENOG4106DSS Tartrate dehydratase subunit alpha HV352_RS03225 ENOG4105EJC lysr family transcriptional regulator HV352_RS03230 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HV352_RS03235 ENOG4107ZVW dihydroneopterin aldolase HV352_RS03240 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HV352_RS03245 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HV352_RS03250 ENOG4106MWK domain protein HV352_RS03255 ENOG4105I7R Adenylate cyclase HV352_RS03260 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HV352_RS03265 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HV352_RS03275 ENOG4105W0Z cytoplasmic protein HV352_RS03285 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) HV352_RS03295 ENOG4108MR7 Arylsulfotransferase HV352_RS03310 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV352_RS03315 ENOG4106032 Glutathionylspermidine synthase HV352_RS03320 ENOG4105F1G UPF0441 protein HV352_RS03330 ENOG41087AY ADP-Ribose pyrophosphatase HV352_RS03335 ENOG4108SX3 cytoplasmic protein HV352_RS03340 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV352_RS03345 ENOG4105IPS esterase HV352_RS03350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV352_RS03355 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV352_RS03360 ENOG4105NF4 modulator of drug activity HV352_RS03365 ENOG4105DHQ Histidine kinase HV352_RS03370 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV352_RS03375 ENOG4105H4F exported protein HV352_RS03380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV352_RS03385 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV352_RS03390 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV352_RS03395 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV352_RS03400 ENOG4105CCT upf0313 protein HV352_RS03410 ENOG4105CV8 reductase HV352_RS03415 ENOG4108I6A alcohol dehydrogenase HV352_RS03420 ENOG4105CF7 AraC family transcriptional regulator HV352_RS03425 ENOG4108K81 inner membrane protein YghB HV352_RS03430 ENOG4105C28 cystathionine HV352_RS03435 ENOG4105CWK Biopolymer transport protein, ExbB HV352_RS03440 ENOG4108ZZF transport protein (ExbD) HV352_RS03460 ENOG4105CPC Aldo Keto reductase HV352_RS03470 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS03475 ENOG410900S Protein of unknown function (DUF2623) HV352_RS03480 ENOG4105E3S small subunit HV352_RS03485 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV352_RS03490 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HV352_RS03495 ENOG4105DPX Hydrogenase, large subunit HV352_RS03500 ENOG4108USZ hydrogenase HV352_RS03505 ENOG4108WGS hydrogenase 2-specific chaperone HV352_RS03510 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV352_RS03515 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HV352_RS03520 ENOG4105CYM Glutathione S-transferase HV352_RS03525 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HV352_RS03530 ENOG4106032 Glutathionylspermidine synthase HV352_RS03555 ENOG4108ZG0 Ompa motb domain protein HV352_RS03565 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV352_RS03710 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS03720 ENOG4108UQV Membrane HV352_RS03725 ENOG4105CXN decarboxylase HV352_RS03730 ENOG4105EAA nucleoside HV352_RS03735 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HV352_RS03740 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HV352_RS03745 ENOG4105CEN a g-specific adenine glycosylase HV352_RS03755 ENOG41090ED Protein with unknown function (DUF469) HV352_RS03760 ENOG4105K33 Periplasmic Protein HV352_RS03765 ENOG4105HDK L-asparaginase HV352_RS03775 ENOG4105CSA Coproporphyrinogen iii oxidase HV352_RS03785 ENOG4105VZ9 UPF0235 protein HV352_RS03790 ENOG4108VIA integral membrane protein HV352_RS03795 ENOG4105DFA alanine racemase domain protein HV352_RS03815 ENOG4105CZX twitching motility protein HV352_RS03820 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HV352_RS03825 ENOG4108UJU UPF0301 protein HV352_RS03830 ENOG4105D7Z glutathione synthase HV352_RS03835 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV352_RS03840 ENOG4105RWS endonuclease I HV352_RS03845 ENOG4105GPY SprT protein HV352_RS03850 ENOG4107QNK )-transporter HV352_RS03855 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HV352_RS03870 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV352_RS03885 ENOG4108K0D peptidase, M48 HV352_RS03890 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV352_RS03895 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV352_RS03900 ENOG4105CTS PTS system mannitol-specific HV352_RS03905 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV352_RS03910 ENOG4108Q8A Fructose-1,6-bisphosphatase HV352_RS03915 ENOG4108R4K DNA-binding, transcriptional regulator HV352_RS03920 ENOG4107Z1W Fructose transport system kinase HV352_RS03925 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV352_RS03930 ENOG4105BZA Phosphoglycerate kinase HV352_RS03935 ENOG4105D2N Aldolase HV352_RS03940 ENOG4105C5B carbamate kinase HV352_RS03950 ENOG4107R1Q Membrane protein FdrA HV352_RS03955 ENOG4107REC cytoplasmic protein HV352_RS03960 ENOG4105G5A Protein of unknown function (DUF2877) HV352_RS03965 ENOG4107653 Transcriptional regulator HV352_RS03970 ENOG4105D64 Mechanosensitive ion channel HV352_RS03980 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HV352_RS03985 ENOG4105MPN Membrane HV352_RS03990 ENOG4105DEQ transcriptional regulator HV352_RS03995 ENOG4105CYC Transferase HV352_RS04000 ENOG4108M7F enoyl-CoA hydratase isomerase HV352_RS04005 ENOG4105DJT lAO AO transport system ATPase HV352_RS04010 ENOG4105D5P Methylmalonyl-coA mutase HV352_RS04015 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HV352_RS04025 ENOG4108JQ1 Dehydrogenase HV352_RS04030 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV352_RS04040 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HV352_RS04050 ENOG4107RAQ aminopeptidase HV352_RS04055 ENOG4105D0A hydroxylase HV352_RS04060 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV352_RS04075 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HV352_RS04080 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV352_RS04085 ENOG4105CS2 ec 3.2.1.21 HV352_RS04090 ENOG4108Q3X Transcriptional regulator HV352_RS04100 ENOG4108UT2 hemolysin iii HV352_RS04110 ENOG4105Y75 tpr repeat protein HV352_RS04115 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV352_RS04120 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV352_RS04125 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV352_RS04130 ENOG4105T95 Thiol disulfide interChange protein HV352_RS04135 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV352_RS04145 ENOG4105CRK lysyL-tRNA synthetase HV352_RS04155 ENOG4108K5P (LipO)protein HV352_RS04170 ENOG4107QQG Dehydrogenase HV352_RS04175 ENOG4108IAJ Nad-dependent epimerase dehydratase HV352_RS04180 ENOG4106EYY HV352_RS04185 ENOG4107TAE Glycosyl transferase (Group 1 HV352_RS04190 ENOG4107U8J Export protein HV352_RS04195 ENOG41090SZ ABC-2 type transporter HV352_RS04200 ENOG4105EY8 ABC transporter HV352_RS04205 ENOG4105ECX polysaccharide export HV352_RS04210 ENOG4106PQC HV352_RS04220 ENOG4108TUY outer membrane protein PgaA HV352_RS04225 ENOG4107BJW polysaccharide deacetylase HV352_RS04230 ENOG4105CND Glycosyl transferase, family 2 HV352_RS04240 ENOG4105VR1 Pfam:DUF1271 HV352_RS04245 ENOG410830R acetyltransferase HV352_RS04250 ENOG4108NUU Transcriptional regulator HV352_RS04255 ENOG4107SNB ankyrin repeat protein YahD HV352_RS04260 ENOG4105N16 Protein of unknown function (DUF2877) HV352_RS04265 ENOG4107R1Q Membrane protein FdrA HV352_RS04270 ENOG4107REC cytoplasmic protein HV352_RS04280 ENOG4105C5B carbamate kinase HV352_RS04285 ENOG4105DZC cytosine deaminase HV352_RS04290 ENOG41061MD high-affinity nickel-transporter HV352_RS04300 ENOG4108MHD transport protein HV352_RS04310 ENOG4105C5Q Transcriptional regulator HV352_RS04315 ENOG4105CHU acetyl-coa acetyltransferase HV352_RS04325 ENOG4105CHR reductase HV352_RS04340 ENOG4105RQF LysR family Transcriptional regulator HV352_RS04350 ENOG4105DDV Transcriptional regulator (LacI family HV352_RS04365 ENOG4107S74 Lysophospholipid transporter LplT HV352_RS04370 ENOG4105CPC Aldo Keto reductase HV352_RS04375 ENOG4105SUV lipoprotein YgdR HV352_RS04380 ENOG4105EE5 Membrane protein terC HV352_RS04395 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV352_RS04410 ENOG4105IPU prepilin peptidase dependent protein A HV352_RS04415 ENOG4105JCS prepilin peptidase dependent protein HV352_RS04420 ENOG4105SEN Protein of unknown function (DUF2509) HV352_RS04425 ENOG4105RVB Prepilin peptidase dependent protein c HV352_RS04430 ENOG4105DSY exodeoxyribonuclease V, gamma HV352_RS04435 ENOG4107QXK peptidase HV352_RS04440 ENOG4107QKA exodeoxyribonuclease V beta HV352_RS04445 ENOG4107QYX exodeoxyribonuclease v alpha HV352_RS04450 ENOG4108EKC n-acetylglutamate synthase HV352_RS04455 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV352_RS04475 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV352_RS04480 ENOG4105CUZ uba thif-type nad fad binding protein HV352_RS04485 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV352_RS04490 ENOG4105C9B Cysteine desulfurase HV352_RS04495 ENOG4105M5B (LipO)protein HV352_RS04500 ENOG4105ETT transcriptional Regulator, LysR family HV352_RS04505 ENOG4105M08 Membrane HV352_RS04510 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HV352_RS04515 ENOG4107EDW L-fucose operon activator HV352_RS04525 ENOG4105CMG Carbohydrate kinase HV352_RS04530 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HV352_RS04535 ENOG4105C2J ABC transporter HV352_RS04540 ENOG4105CNN ABC, transporter HV352_RS04550 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV352_RS04560 ENOG4107W7X Aldolase HV352_RS04565 ENOG4105C0A alcohol dehydrogenase HV352_RS04575 ENOG4105EJQ L-serine dehydratase HV352_RS04580 ENOG4105C44 Serine transporter HV352_RS04585 ENOG4105EWT decarboxylase family HV352_RS04590 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HV352_RS04595 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HV352_RS04600 ENOG4105WP7 tRNA pseudouridine synthase C HV352_RS04605 ENOG4105DR9 pseudouridine synthase HV352_RS04610 ENOG4105QDK Flavodoxin HV352_RS04615 ENOG4105DJB Major Facilitator Superfamily HV352_RS04620 ENOG4105EQX glucarate dehydratase HV352_RS04625 ENOG4105EQX glucarate dehydratase HV352_RS04630 ENOG4105BZW Glycerate kinase HV352_RS04635 ENOG4105BZU Histidine kinase HV352_RS04640 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HV352_RS04645 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV352_RS04650 ENOG4105DXN mazG family HV352_RS04665 ENOG4105QEK Transcriptional regulator HV352_RS04675 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HV352_RS04680 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV352_RS04685 ENOG4108CWB sugar kinase ygcE HV352_RS04690 ENOG4108ITV Inner membrane protein yqcE HV352_RS04695 ENOG4105CHR reductase HV352_RS04700 ENOG4107R3A FAD linked oxidase domain protein HV352_RS04705 ENOG4105C54 Major Facilitator superfamily HV352_RS04710 ENOG4106IKH Electron transfer flavoprotein HV352_RS04715 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HV352_RS04720 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HV352_RS04725 ENOG4105WQV ferredoxin-like protein HV352_RS04730 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV352_RS04735 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV352_RS04755 ENOG4108MXK alkaline phosphatase isozyme conversion HV352_RS04765 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HV352_RS04775 ENOG4105N0Z inner membrane protein ygbE HV352_RS04780 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV352_RS04795 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HV352_RS04800 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HV352_RS04805 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HV352_RS04810 ENOG4108K5P (LipO)protein HV352_RS04845 ENOG4105BZU Histidine kinase HV352_RS04850 ENOG4105CC5 ABC transporter HV352_RS04855 ENOG4105CC5 ABC transporter HV352_RS04860 ENOG4105DIK (ABC) transporter HV352_RS04870 ENOG4105VXR cytoplasmic protein HV352_RS04880 ENOG4105C45 hydrogenase expression formation protein (HypE) HV352_RS04885 ENOG4105CQS hydrogenase expression formation protein HypD HV352_RS04890 ENOG41083WG hydrogenase assembly chaperone HV352_RS04895 ENOG4107RSS Hydrogenase accessory protein HypB HV352_RS04900 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV352_RS04905 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV352_RS04910 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV352_RS04915 ENOG4107R30 NADH dehydrogenase HV352_RS04920 ENOG4107TDF Formate hydrogenlyase subunit 4 HV352_RS04925 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV352_RS04930 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV352_RS04935 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV352_RS04940 ENOG4105I6X formate hydrogenlyase maturation HV352_RS04945 ENOG4108MG9 hydrogenase 3 maturation protease HV352_RS04960 ENOG4105CS2 ec 3.2.1.21 HV352_RS04965 ENOG4105C5Y PTS System HV352_RS04970 ENOG4105DDV Transcriptional regulator (LacI family HV352_RS04975 ENOG4108RC0 Electron transport protein HV352_RS04980 ENOG4105C8H hydrogenase maturation protein Hypf HV352_RS04985 ENOG4107QZF nitrite reductase NADPH large subunit HV352_RS04990 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HV352_RS04995 ENOG4108JUA Transcriptional regulator HV352_RS05000 ENOG4105C2X Arabinose 5-phosphate isomerase HV352_RS05005 ENOG410804X Transcriptional regulator HV352_RS05010 ENOG4105J92 DNA-binding transcriptional activator GutM HV352_RS05015 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HV352_RS05020 ENOG4105VI0 Pts system, glucitol sorbitol-specific HV352_RS05025 ENOG4105DZY Pts system, glucitol sorbitol-specific HV352_RS05030 ENOG410787A Pts system, glucitol sorbitol-specific HV352_RS05035 ENOG4105CVE Lytic murein transglycosylase HV352_RS05040 ENOG4107TH8 cina domain protein HV352_RS05045 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HV352_RS05055 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HV352_RS05060 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV352_RS05090 ENOG4107VXZ Hydrolase HV352_RS05095 ENOG4105W39 Membrane HV352_RS05105 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HV352_RS05110 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV352_RS05115 ENOG4105CW7 secretion protein, HlyD family HV352_RS05120 ENOG4105NTK Transcriptional repressor Mpra HV352_RS05125 ENOG4105ZED uncharacterized protein ygaH HV352_RS05130 ENOG4108UMN azlc family HV352_RS05140 ENOG4105GIJ Glycine betaine HV352_RS05145 ENOG4108HQS Glycine betaine HV352_RS05150 ENOG4108IJ7 Glycine betaine HV352_RS05155 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV352_RS05160 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV352_RS05165 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HV352_RS05170 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV352_RS05175 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV352_RS05185 ENOG4108WMJ Protein of unknown function (DUF2002) HV352_RS05190 ENOG4108RNS Exports L-alanine (By similarity) HV352_RS05195 ENOG4108X73 DNA- binding protein HV352_RS05205 ENOG4108V62 Rhodanese domain protein HV352_RS05210 ENOG41080HT Transcriptional regulator, arsr family HV352_RS05215 ENOG4105VPI YqaE family transport protein HV352_RS05220 ENOG4109066 lysm domain bon superfamily protein HV352_RS05225 ENOG4108PVQ transcriptional regulator HV352_RS05230 ENOG4105C85 amino acid HV352_RS05235 ENOG4108JPW Aminotransferase HV352_RS05240 ENOG4105C26 Dehydrogenase HV352_RS05245 ENOG4105D5U fad dependent oxidoreductase HV352_RS05255 ENOG4105KT7 mgtC SapB transporter HV352_RS05260 ENOG4105EAA nucleoside HV352_RS05270 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS05275 ENOG4105CHR reductase HV352_RS05305 ENOG4105DHQ Histidine kinase HV352_RS05315 ENOG4105CW0 outer membrane usher protein HV352_RS05320 ENOG4108NAE Fimbrial chaperone protein HV352_RS05365 ENOG41088YS Glycosyl transferase (Group 1 HV352_RS05370 ENOG4107RA4 Glycosyl transferase (Group 1 HV352_RS05385 ENOG4105CMR udp-glucose 4-epimerase HV352_RS05395 ENOG4107B2H carbonic anhydrase HV352_RS05400 ENOG4105C87 Aminotransferase class I and II HV352_RS05405 ENOG4105DFD Na H antiporter HV352_RS05410 ENOG4108K2B transcriptional regulator HV352_RS05420 ENOG4108JUB Transcriptional regulator HV352_RS05425 ENOG4107RCH Diaminopropionate ammonia-lyase HV352_RS05430 ENOG4107S4Y M20 DapE family protein YgeY HV352_RS05440 ENOG4105DJB Major Facilitator Superfamily HV352_RS05445 ENOG4108WQH regulatoR HV352_RS05450 ENOG4105BZU Histidine kinase HV352_RS05455 ENOG4108V08 YfdX protein HV352_RS05470 ENOG4105BZS acriflavin resistance protein HV352_RS05475 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV352_RS05480 ENOG4105Y4Z Outer Membrane Lipoprotein HV352_RS05500 ENOG4105BZU Histidine kinase HV352_RS05520 ENOG4106J6E HV352_RS05525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV352_RS05560 ENOG4105KSC Transcriptional regulator, TraR DksA family HV352_RS05565 ENOG4105DFE Dna adenine methylase HV352_RS05595 ENOG4105ED4 portal protein HV352_RS05685 ENOG4105UZW Tail fiber assembly protein HV352_RS05690 ENOG4105MEV Acyl-transferase HV352_RS05730 ENOG4105ZTC transcriptional activator, Ogr delta HV352_RS05745 ENOG4105BZ1 (ABC) transporter HV352_RS05765 ENOG4108Z1B Cyclase dehydrase HV352_RS05770 ENOG4105VDB UPF0125 protein HV352_RS05775 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV352_RS05780 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV352_RS05795 ENOG4108JU6 CBS domain protein HV352_RS05800 ENOG4106KVJ cytochrome C assembly protein HV352_RS05805 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV352_RS05810 ENOG4105K5M 30s ribosomal protein S16 HV352_RS05815 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HV352_RS05825 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HV352_RS05830 ENOG41090EK ompa motb domain protein HV352_RS05835 ENOG4108KHX Diguanylate cyclase HV352_RS05840 ENOG4108WS1 HV352_RS05845 ENOG4105QP9 Protein of unknown function (DUF2799) HV352_RS05850 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV352_RS05855 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV352_RS05860 ENOG4105CQC Prephenate dehydratase HV352_RS05870 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV352_RS05875 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV352_RS05880 ENOG4105C34 Pseudouridine synthase HV352_RS05885 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV352_RS05890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV352_RS05920 ENOG4105CSH Transporter HV352_RS05925 ENOG4105T42 (LipO)protein HV352_RS05930 ENOG4105JIM Phosphatidylserine synthase HV352_RS05935 ENOG4105CD5 CoA-binding domain protein HV352_RS05940 ENOG4106IUH DTW domain containing protein HV352_RS05945 ENOG4105K63 Thioredoxin HV352_RS05950 ENOG4105EIB trna rrna methyltransferase HV352_RS05965 ENOG4105C1J atp-dependent rna helicase HV352_RS05975 ENOG4108IYU L-aspartate oxidase HV352_RS05985 ENOG4105EMN RNA polymerase sigma factor HV352_RS05995 ENOG4105VQK sigma E regulatory protein, MucB RseB HV352_RS06000 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV352_RS06010 ENOG4105C3F Signal peptidase i HV352_RS06020 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HV352_RS06030 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV352_RS06035 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HV352_RS06040 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV352_RS06045 ENOG4106G6Q Transcriptional regulator HV352_RS06050 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV352_RS06060 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV352_RS06065 ENOG4108Z6B deaminase HV352_RS06070 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV352_RS06080 ENOG4107WP9 Histidine kinase HV352_RS06085 ENOG4108SKK alpha helix protein HV352_RS06090 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV352_RS06095 ENOG4108YZA Nitrogen regulatory protein pii HV352_RS06100 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV352_RS06105 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HV352_RS06130 ENOG4105FUY alpha subunit HV352_RS06135 ENOG4108W5M transcriptional regulator HV352_RS06140 ENOG4105I74 Fimbrial protein HV352_RS06145 ENOG4105CW0 outer membrane usher protein HV352_RS06150 ENOG4108VCD Chaperone HV352_RS06155 ENOG4105Q10 Fimbrial-like protein HV352_RS06160 ENOG4105D8G Major Facilitator superfamily HV352_RS06165 ENOG4108MN2 Stationary phase inducible protein CsiE HV352_RS06170 ENOG4105C2X Arabinose 5-phosphate isomerase HV352_RS06175 ENOG4105EF1 ribulokinase HV352_RS06185 ENOG4105CNN ABC, transporter HV352_RS06190 ENOG4105C2J ABC transporter HV352_RS06200 ENOG41065CD Exported protein HV352_RS06205 ENOG4105D7X high-affinity nickel-transporter HV352_RS06210 ENOG4105ECY inositol monophosphatase HV352_RS06215 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HV352_RS06220 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV352_RS06230 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV352_RS06235 ENOG4108Z4V iron-sulfur cluster assembly HV352_RS06250 ENOG4108ZIT Ferredoxin, 2FE-2S HV352_RS06255 ENOG4105WVQ Fe-S assembly protein IscX HV352_RS06260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV352_RS06265 ENOG4105YYA enhanced serine sensitivity protein SseB HV352_RS06270 ENOG4105KHC sulfurtransferase HV352_RS06275 ENOG4105DN3 alpha-2-macroglobulin domain protein HV352_RS06280 ENOG4108JQB penicillin-binding protein 1C HV352_RS06290 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HV352_RS06295 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HV352_RS06300 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HV352_RS06310 ENOG4105N21 Membrane HV352_RS06315 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV352_RS06320 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HV352_RS06325 ENOG4105DUX Transporter HV352_RS06335 ENOG4105VPD cellular component movement HV352_RS06340 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV352_RS06345 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV352_RS06355 ENOG41062G3 Protein of unknown function (DUF2633) HV352_RS06360 ENOG4105BZU Histidine kinase HV352_RS06365 ENOG4105C9X ppx gppa phosphatase HV352_RS06370 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HV352_RS06375 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV352_RS06385 ENOG4105CS2 ec 3.2.1.21 HV352_RS06390 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HV352_RS06395 ENOG4105C2W permease HV352_RS06400 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV352_RS06405 ENOG4105K89 arsenate reductase HV352_RS06410 ENOG4105ERG peptidase m48, ste24p HV352_RS06415 ENOG4105C02 permease HV352_RS06420 ENOG41074DU domain protein HV352_RS06425 ENOG4108P2H Inner membrane protein YjiG HV352_RS06430 ENOG4105DYB Isoaspartyl dipeptidase HV352_RS06435 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV352_RS06440 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV352_RS06450 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV352_RS06460 ENOG4105CGZ zinc metallopeptidase HV352_RS06465 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HV352_RS06470 ENOG4106KED esterase YpfH HV352_RS06480 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HV352_RS06485 ENOG4105KUZ arsenate reductase HV352_RS06495 ENOG4105BZS acriflavin resistance protein HV352_RS06500 ENOG4105BZU Histidine kinase HV352_RS06505 ENOG4105BZ8 glutamate synthase HV352_RS06515 ENOG4108PVD exported protein HV352_RS06520 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV352_RS06525 ENOG4105C6K Malic enzyme HV352_RS06530 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HV352_RS06535 ENOG4106S4J ethanolamine utilization protein EutP HV352_RS06540 ENOG4105NDK ethanolamine utilization protein HV352_RS06545 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HV352_RS06550 ENOG4108IJ2 phosphate acetyltransferase HV352_RS06555 ENOG4105KNY Microcompartments protein HV352_RS06560 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV352_RS06565 ENOG4108EKI Dehydrogenase HV352_RS06570 ENOG4107YMV ethanolamine utilization protein HV352_RS06575 ENOG4105C0A alcohol dehydrogenase HV352_RS06580 ENOG4105ENY Ethanolamine utilization protein eutH HV352_RS06585 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HV352_RS06590 ENOG4105CPD ethanolamine ammonia-lyase HV352_RS06600 ENOG4106D67 ethanolamine utilization protein HV352_RS06605 ENOG4108X49 Ethanolamine utilization protein EutK HV352_RS06610 ENOG4108K3Z AraC family transcriptional regulator HV352_RS06620 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV352_RS06625 ENOG4108R6G acetyltransferase HV352_RS06630 ENOG4105QZU Inner membrane protein YfeZ HV352_RS06635 ENOG4105E7K (LipO)protein HV352_RS06640 ENOG4105EZR dyp-type peroxidase family protein HV352_RS06645 ENOG4105CH7 arginosuccinase HV352_RS06650 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV352_RS06655 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV352_RS06660 ENOG4105JXH GntR family transcriptional regulator HV352_RS06665 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HV352_RS06670 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV352_RS06675 ENOG4108I5D sulfate abc transporter HV352_RS06680 ENOG4105ECW sulfate abc transporter HV352_RS06685 ENOG4108IJ6 ABC transporter HV352_RS06690 ENOG4105C6T cysteine synthase HV352_RS06695 ENOG41089BK Glutamine amido-transferase HV352_RS06700 ENOG4105CSW GntR family transcriptional regulator HV352_RS06705 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV352_RS06715 ENOG4105C5Y PTS System HV352_RS06720 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV352_RS06725 ENOG4105KZ7 phosphocarrier protein hpr HV352_RS06730 ENOG4105C6T cysteine synthase HV352_RS06745 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HV352_RS06750 ENOG4105VRT cytoplasmic protein HV352_RS06755 ENOG4105DHU Bile acid HV352_RS06760 ENOG4108M0I Transcriptional regulator HV352_RS06785 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HV352_RS06790 ENOG4105GXM Putative transcription regulator (DUF1323) HV352_RS06795 ENOG4105HZG regulatoR HV352_RS06810 ENOG4105D9N nucleoside HV352_RS06815 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HV352_RS06825 ENOG4105CE4 GlcNAc 6-P deacetylase HV352_RS06830 ENOG4105C83 adenylosuccinate lyase HV352_RS06835 ENOG4105CI1 PTS System HV352_RS06840 ENOG4109076 Conserved Protein HV352_RS06845 ENOG4105CPC Aldo Keto reductase HV352_RS06850 ENOG4107RA9 decarboxylase HV352_RS06860 ENOG4105CHC glucokinase (EC 2.7.1.2) HV352_RS06865 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV352_RS06870 ENOG410863U PTS System HV352_RS06875 ENOG4105DC7 peptidase M24 HV352_RS06880 ENOG4105CN9 Peptidase m42 family protein HV352_RS06885 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV352_RS06895 ENOG4108CIP transcriptional regulator HV352_RS06900 ENOG4105DY9 regulatoR HV352_RS06905 ENOG4108HRK Histidine kinase HV352_RS06910 ENOG4105CHM Aminotransferase HV352_RS06925 ENOG4105D1S lipid A biosynthesis HV352_RS06930 ENOG4105W9M Membrane HV352_RS06935 ENOG4105CXY transporter HV352_RS06940 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HV352_RS06950 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HV352_RS06955 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV352_RS06960 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS06965 ENOG4105D44 asparaginase HV352_RS06980 ENOG4105DFP Integrase HV352_RS07065 ENOG4108S1U HV352_RS07105 ENOG4108MXB Protein of unknown function (DUF968) HV352_RS07130 ENOG4105NVB glycoside hydrolase, family 19 HV352_RS07160 ENOG4105CAR Terminase, large subunit HV352_RS07210 ENOG4105TKZ Tail Sheath HV352_RS07235 ENOG4108NKR DNA circulation protein HV352_RS07255 ENOG4108T86 baseplate J family protein HV352_RS07260 ENOG4105Y0G tail protein HV352_RS07280 ENOG4105Y50 Virulence Protein HV352_RS07290 ENOG4105KT5 UmuD protein HV352_RS07295 ENOG4105S64 Formate nitrite transporter HV352_RS07300 ENOG410903C (LipO)protein HV352_RS07305 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV352_RS07310 ENOG4105KZW UPF0381 protein HV352_RS07315 ENOG4105CHU acetyl-coa acetyltransferase HV352_RS07320 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV352_RS07325 ENOG4108BY2 phosphohistidine phosphatase HV352_RS07330 ENOG4108DG9 Smr protein MutS2 HV352_RS07335 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HV352_RS07345 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HV352_RS07350 ENOG4105EJ9 Membrane HV352_RS07355 ENOG4108BPE -transporting atpase HV352_RS07360 ENOG4105MH2 YfcL protein HV352_RS07365 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV352_RS07370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV352_RS07395 ENOG4105F9N Major Facilitator Superfamily HV352_RS07400 ENOG4106WZ1 flagella biosynthesis regulator HV352_RS07405 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HV352_RS07410 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV352_RS07420 ENOG4105DQR SNARE associated Golgi HV352_RS07430 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV352_RS07435 ENOG4108S3P Sporulation domain protein HV352_RS07440 ENOG4105E96 Colicin v production protein HV352_RS07445 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV352_RS07450 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV352_RS07455 ENOG4105E89 ABC transporter HV352_RS07460 ENOG4105E89 ABC transporter HV352_RS07465 ENOG4105DSP amino acid AbC transporter HV352_RS07470 ENOG4106YG3 ABC transporter HV352_RS07475 ENOG4108JEH abc transporter atp-binding protein HV352_RS07480 ENOG4105D9U N-acetyltransferase HV352_RS07485 ENOG4105ECP epimerase HV352_RS07490 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV352_RS07495 ENOG4105CYM Glutathione S-transferase HV352_RS07500 ENOG4108SHQ Glutathione S-transferase HV352_RS07505 ENOG4108RE9 Phosphodiesterase HV352_RS07510 ENOG4105PTV Nudix Hydrolase HV352_RS07515 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV352_RS07520 ENOG4105C6K Malic enzyme HV352_RS07525 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV352_RS07530 ENOG4105PQ6 UPF0208 membrane protein HV352_RS07540 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV352_RS07545 ENOG4107QWE )-transporter HV352_RS07550 ENOG4105DK2 UPF0207 protein HV352_RS07555 ENOG4105CHM Aminotransferase HV352_RS07560 ENOG4107NQ8 LysR family Transcriptional regulator HV352_RS07570 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV352_RS07575 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV352_RS07580 ENOG4105GKE subunit e HV352_RS07585 ENOG4107QIZ NADH dehydrogenase HV352_RS07590 ENOG4108IEH NADH dehydrogenase subunit g HV352_RS07595 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HV352_RS07605 ENOG4107UFS subunit j HV352_RS07615 ENOG4105D65 subunit l HV352_RS07620 ENOG4105C8S subunit m HV352_RS07625 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV352_RS07635 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV352_RS07640 ENOG4107YB6 acetyltransferase, (GNAT) family HV352_RS07645 ENOG4105TNS Conserved Protein HV352_RS07650 ENOG4105E4F Isochorismate synthase HV352_RS07660 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HV352_RS07665 ENOG4108IPT Naphthoate synthase HV352_RS07675 ENOG4105CEY Amp-dependent synthetase and ligase HV352_RS07680 ENOG4106GZG polymyxin resistance protein B HV352_RS07725 ENOG4108UII YfaZ family HV352_RS07730 ENOG4108EWA cinA-like protein HV352_RS07735 ENOG4107258 Transcriptional regulator HV352_RS07745 ENOG4105CSP Major Facilitator Superfamily HV352_RS07765 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV352_RS07770 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HV352_RS07775 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV352_RS07780 ENOG4105CXY transporter HV352_RS07785 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV352_RS07790 ENOG4105XPH Ferredoxin HV352_RS07795 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV352_RS07800 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV352_RS07805 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HV352_RS07810 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV352_RS07815 ENOG4105CHU acetyl-coa acetyltransferase HV352_RS07820 ENOG4105CRW Short chain fatty acid transporter HV352_RS07825 ENOG4107QNJ CoA-transferase subunit B HV352_RS07830 ENOG4107QP7 CoA-transferase subunit A HV352_RS07835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV352_RS07840 ENOG4105BZU Histidine kinase HV352_RS07845 ENOG4105BZU Histidine kinase HV352_RS07850 ENOG41068CG regulatoR HV352_RS07855 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV352_RS07860 ENOG4105FCK Membrane HV352_RS07865 ENOG4105CJ2 (LipO)protein HV352_RS07870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV352_RS07875 ENOG4105CF1 Alkylated DNA repair protein HV352_RS07880 ENOG4105IBP Cyclic peptide transporter HV352_RS07885 ENOG4105CJW magnesium transporter HV352_RS07890 ENOG4105CHH sulfate transporter HV352_RS07895 ENOG4105DWT malate dehydrogenase (quinone) HV352_RS07905 ENOG4108ZNS ferredoxin-type protein NapF HV352_RS07910 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HV352_RS07920 ENOG4108BGM Quinol dehydrogenase periplasmic component HV352_RS07925 ENOG4105GXZ Ferredoxin-type protein NapH HV352_RS07930 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HV352_RS07935 ENOG4105CUW cytochrome C-TYPE protein HV352_RS07940 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HV352_RS07945 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HV352_RS07950 ENOG41060IM Heme exporter protein HV352_RS07955 ENOG4105X3C heme exporter protein HV352_RS07960 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HV352_RS07965 ENOG4105DA4 cytochrome c-type biogenesis protein HV352_RS07970 ENOG4107QX9 Thiol disulfide interChange protein HV352_RS07975 ENOG4105KWW Biogenesis protein HV352_RS07980 ENOG4105WH1 Two component transcriptional regulator luxr family HV352_RS07990 ENOG4105E68 Sulfatase HV352_RS07995 ENOG4105PAN UPF0352 protein HV352_RS08000 ENOG4106V8H Nucleoid-associated protein HV352_RS08005 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HV352_RS08010 ENOG4105CFI type iii restriction protein res subunit HV352_RS08015 ENOG4105I08 Pseudouridine synthase HV352_RS08020 ENOG4105C2C drug resistance transporter, Bcr CflA HV352_RS08025 ENOG4105HG6 HV352_RS08030 ENOG4108JQ5 ABC transporter HV352_RS08035 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV352_RS08040 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV352_RS08045 ENOG4105E43 Extracellular solute-binding protein, family 5 HV352_RS08050 ENOG4105CXC rtn protein HV352_RS08055 ENOG4107TT5 NLP P60 protein HV352_RS08060 ENOG41076MN Phosphoesterase, PA-phosphatase related HV352_RS08065 ENOG4105CKI cobalamin synthesis protein HV352_RS08070 ENOG4105DEI Mannitol dehydrogenase HV352_RS08075 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HV352_RS08080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV352_RS08085 ENOG4105CUW cytochrome C-TYPE protein HV352_RS08090 ENOG4108EM1 reductase HV352_RS08095 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HV352_RS08100 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV352_RS08105 ENOG4105KRS Proteinase inhibitor HV352_RS08110 ENOG4105S8Q sugar efflux transporter HV352_RS08115 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV352_RS08120 ENOG4105DE4 1-phosphofructokinase HV352_RS08125 ENOG4105DM4 PTS System HV352_RS08130 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV352_RS08140 ENOG4107YNJ LysR family Transcriptional regulator HV352_RS08145 ENOG4105DD7 kinase (PfkB family HV352_RS08150 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HV352_RS08155 ENOG4105D9N nucleoside HV352_RS08160 ENOG4105DD7 kinase (PfkB family HV352_RS08165 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HV352_RS08170 ENOG4105HMI Membrane HV352_RS08175 ENOG4105DUM transcriptional regulator, lysR family HV352_RS08180 ENOG4108IQI permease HV352_RS08185 ENOG4105D05 Receptor HV352_RS08195 ENOG4105EUJ GTP cyclohydrolase i HV352_RS08200 ENOG4105DHF Membrane HV352_RS08205 ENOG41060NJ transcriptional regulator HV352_RS08215 ENOG4105C2J ABC transporter HV352_RS08220 ENOG4107SDZ Galactoside transport system permease protein mglC HV352_RS08225 ENOG4107SJI Dehydrogenase HV352_RS08230 ENOG4105BZ8 glutamate synthase HV352_RS08235 ENOG4105Y9N Membrane HV352_RS08240 ENOG4107GZ4 SanA protein HV352_RS08245 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HV352_RS08250 ENOG41067MG lrgb family HV352_RS08255 ENOG4105VAW lrga family HV352_RS08280 ENOG4108RXX maleylacetoacetate isomerase HV352_RS08285 ENOG4105MSY salicylate hydroxylase HV352_RS08290 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV352_RS08300 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV352_RS08305 ENOG4105KHU inner membrane protein YohD HV352_RS08310 ENOG41069YE inner membrane protein yohC HV352_RS08315 ENOG41061WM D-Alanyl-D-Alanine HV352_RS08320 ENOG4105CXG d-lactate dehydrogenase HV352_RS08325 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV352_RS08330 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV352_RS08335 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV352_RS08340 ENOG4108IJ8 ABC transporter HV352_RS08345 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV352_RS08355 ENOG4108XDN Transcriptional regulator HV352_RS08360 ENOG4108HRK Histidine kinase HV352_RS08365 ENOG4108NEV two component transcriptional regulator, LytTR family HV352_RS08370 ENOG4108W15 Protein of unknown function (DUF1456) HV352_RS08375 ENOG4108YCW (LipO)protein HV352_RS08385 ENOG4105D1F ATP-binding protein HV352_RS08400 ENOG4108MQF Chaperone HV352_RS08405 ENOG4105CW0 outer membrane usher protein HV352_RS08415 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV352_RS08420 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HV352_RS08425 ENOG4105DWF phosphomethylpyrimidine kinase HV352_RS08430 ENOG4105FDP GntR family transcriptional regulator HV352_RS08435 ENOG4108TFM Kinase, PfkB family HV352_RS08440 ENOG4108KD5 ADP-ribosylation crystallin J1 HV352_RS08445 ENOG4105EAA nucleoside HV352_RS08450 ENOG4105EIE fructose-bisphosphate aldolase HV352_RS08455 ENOG4107TE5 Lipid kinase HV352_RS08460 ENOG4106TNF Periplasmic binding protein HV352_RS08465 ENOG4105DMR ABC, transporter HV352_RS08470 ENOG4105GBT ABC transporter HV352_RS08475 ENOG4106PMH Extracellular solute-binding protein family 3 HV352_RS08480 ENOG4105E5Z arginine transporter ATP-binding subunit HV352_RS08485 ENOG41064MM (LipO)protein HV352_RS08495 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV352_RS08500 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV352_RS08505 ENOG4105CGD Nad-dependent epimerase dehydratase HV352_RS08510 ENOG4105C5W Aldolase HV352_RS08515 ENOG4105C7K acetolactate synthase HV352_RS08525 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV352_RS08530 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV352_RS08540 ENOG4105DWU Membrane HV352_RS08545 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV352_RS08550 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV352_RS08555 ENOG4108MJ5 VirK protein HV352_RS08560 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV352_RS08570 ENOG4105VEQ Cold shock protein HV352_RS08575 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HV352_RS08580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV352_RS08585 ENOG4105CFP Peptidase U32 HV352_RS08590 ENOG4105KWI UPF0339 protein HV352_RS08595 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV352_RS08600 ENOG4105EB3 Histidine kinase HV352_RS08605 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV352_RS08610 ENOG4105BZS acriflavin resistance protein HV352_RS08615 ENOG4105BZS acriflavin resistance protein HV352_RS08630 ENOG4105R8A Heat shock protein HV352_RS08635 ENOG4105D03 DNA-3-methyladenine glycosylase II HV352_RS08640 ENOG4105BZU Histidine kinase HV352_RS08650 ENOG4105DHP deoxycytidine triphosphate deaminase HV352_RS08655 ENOG4108GAE asmA family HV352_RS08660 ENOG4105EE5 Membrane protein terC HV352_RS08665 ENOG4105DAY polysaccharide export protein HV352_RS08670 ENOG4105KJF protein tyrosine phosphatase HV352_RS08675 ENOG4105D75 Capsular exopolysaccharide family HV352_RS08680 ENOG41090RK glycosyl transferase HV352_RS08685 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HV352_RS08690 ENOG4107RXY Glycosyl transferase HV352_RS08695 ENOG4108NYJ Colanic acid HV352_RS08700 ENOG4105ECJ Glycosyl Transferase HV352_RS08705 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HV352_RS08710 ENOG4105C0K Gdp-mannose 4,6-dehydratase HV352_RS08715 ENOG4105C30 Nad-dependent epimerase dehydratase HV352_RS08720 ENOG4105FGF GDP-mannose mannosyl hydrolase HV352_RS08725 ENOG4106CD9 glycosyl transferase group 1 HV352_RS08730 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV352_RS08735 ENOG4107QKV phosphomannomutase HV352_RS08740 ENOG4105D3Q Sugar transferase HV352_RS08745 ENOG4105PSV Polysaccharide Biosynthesis Protein HV352_RS08750 ENOG4105C74 pyruvyl transferase HV352_RS08755 ENOG4107T8Q Glycosyl transferase (Group 1 HV352_RS08760 ENOG4105G1A colanic acid biosynthesis protein HV352_RS08765 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV352_RS08770 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HV352_RS08775 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HV352_RS08780 ENOG4107SJB teichoic acid biosynthesis HV352_RS08790 ENOG4105EY8 ABC transporter HV352_RS08800 ENOG4107EF8 Glycosyl transferase (Group 1 HV352_RS08805 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV352_RS08815 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV352_RS08820 ENOG4105C6Y Udp-glucose 6-dehydrogenase HV352_RS08825 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HV352_RS08835 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HV352_RS08840 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV352_RS08845 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV352_RS08850 ENOG4105CIH Imidazole acetol-phosphate transaminase HV352_RS08855 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HV352_RS08870 ENOG4107SRH Nad-dependent epimerase dehydratase HV352_RS08875 ENOG4105EQ1 Transcriptional regulator HV352_RS08885 ENOG4105CUB amino acid HV352_RS08890 ENOG4105CJB Exodeoxyribonuclease I HV352_RS08895 ENOG4108J2R molybdopterin oxidoreductase HV352_RS08900 ENOG4105QAX Iron-sulfur HV352_RS08905 ENOG4108NWD Cytochrome HV352_RS08910 ENOG4105DZ1 carboxypeptidase HV352_RS08915 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HV352_RS08920 ENOG4105DR8 Membrane HV352_RS08930 ENOG4105JZC GHMP kinase HV352_RS08935 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV352_RS08940 ENOG4105KTW ethanolamine utilization protein HV352_RS08945 ENOG4105M3W utilization protein HV352_RS08955 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HV352_RS08965 ENOG4108EKI Dehydrogenase HV352_RS08975 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV352_RS08985 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HV352_RS08995 ENOG4105KNY Microcompartments protein HV352_RS09005 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV352_RS09010 ENOG4108ZFT Dehydratase small subunit HV352_RS09015 ENOG4105YCI dehydratase medium subunit HV352_RS09020 ENOG4105DMB glycerol dehydratase HV352_RS09025 ENOG4105EHR propanediol utilization protein pduB HV352_RS09030 ENOG4105KNY Microcompartments protein HV352_RS09035 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV352_RS09040 ENOG4107XVH Transcriptional regulator HV352_RS09045 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV352_RS09050 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HV352_RS09055 ENOG41081F0 Precorrin-8x methylmutase HV352_RS09060 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HV352_RS09065 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HV352_RS09070 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HV352_RS09075 ENOG4105CIA precorrin-4 C(11)-methyltransferase HV352_RS09080 ENOG4108P62 biosynthesis protein (CbiG) HV352_RS09085 ENOG4105E4R Precorrin-3B C17-methyltransferase HV352_RS09090 ENOG4105QUC reductase HV352_RS09095 ENOG4107PPM cobalt chelatase HV352_RS09100 ENOG4105DVK Precorrin-2 c20-methyltransferase HV352_RS09105 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV352_RS09110 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV352_RS09115 ENOG4108V4M Cobalt abc transporter HV352_RS09125 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV352_RS09130 ENOG4108YZT Adenosylcobinamide kinase HV352_RS09135 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HV352_RS09140 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HV352_RS09145 ENOG4108PXI ErfK YbiS YcfS YnhG HV352_RS09155 ENOG4107RCV ABC transporter, permease HV352_RS09180 ENOG4105ZIT Porin Gram-negative type HV352_RS09185 ENOG4105EST Metal Dependent Phosphohydrolase HV352_RS09190 ENOG4105DVF Cytosine-specific methyltransferase HV352_RS09195 ENOG41090BB DNA mismatch endonuclease (vsr) HV352_RS09200 ENOG4105FDR Membrane HV352_RS09205 ENOG4105CKW Inner membrane protein yedI HV352_RS09210 ENOG4105VNZ cytoplasmic protein HV352_RS09215 ENOG4105YX3 cellular response to acidity HV352_RS09220 ENOG4105VZF DsrB protein HV352_RS09225 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HV352_RS09230 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV352_RS09235 ENOG4105VS8 Flagellar biosynthetic protein fliq HV352_RS09240 ENOG4105CN7 Flagellar biosynthetic protein FliP HV352_RS09245 ENOG4105K0P flagellar biosynthesis protein HV352_RS09250 ENOG4105DD5 Flagellar motor switch protein HV352_RS09255 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV352_RS09260 ENOG4107ZI8 flagellar basal body-associated protein flil HV352_RS09265 ENOG4105WF4 Flagellar hook-length control protein HV352_RS09270 ENOG4105GSA Flagellar export protein flij HV352_RS09275 ENOG4108JIR Flagellum-specific ATP synthase HV352_RS09280 ENOG41090PJ Flagellar assembly protein HV352_RS09285 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV352_RS09290 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HV352_RS09305 ENOG41066VF YeeE YedE family protein HV352_RS09310 ENOG4105JCU Inherit from NOG: (Lipo)protein HV352_RS09315 ENOG4105E5K Alpha-amylase HV352_RS09325 ENOG4105MQ3 flagellar protein FliS HV352_RS09330 ENOG4105DTS flagellar hook-associated HV352_RS09345 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV352_RS09350 ENOG4108M9K flagella biosynthesis protein FliZ HV352_RS09355 ENOG4105EAB amino acid AbC transporter HV352_RS09360 ENOG4105K6H D-cysteine desulfhydrase HV352_RS09365 ENOG4105E5Q amino acid AbC transporter HV352_RS09370 ENOG4105CDA abc transporter atp-binding protein HV352_RS09375 ENOG4105VJY transcriptional regulator HV352_RS09380 ENOG4105XVG cytoplasmic protein HV352_RS09385 ENOG4105WH1 Two component transcriptional regulator luxr family HV352_RS09390 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HV352_RS09415 ENOG41060EU Cold shock-like protein HV352_RS09420 ENOG4105VEQ Cold shock protein HV352_RS09430 ENOG4105CAU Arsenical resistance protein, ArsH HV352_RS09435 ENOG4105KBH arsR family transcriptional regulator HV352_RS09470 ENOG4108KS2 transglutaminase domain protein HV352_RS09480 ENOG410681U heavy metal transport detoxification protein HV352_RS09485 ENOG4106RHG Yeca family HV352_RS09490 ENOG4105E0U tyrosine-specific transport protein HV352_RS09495 ENOG4105VVZ metal-binding protein HV352_RS09500 ENOG41090A1 ferritin HV352_RS09505 ENOG4105P23 (LipO)protein HV352_RS09515 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV352_RS09520 ENOG4105N4N Protein of unknown function (DUF2766) HV352_RS09525 ENOG4108UEC Ferritin-like protein HV352_RS09535 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV352_RS09540 ENOG4105C2J ABC transporter HV352_RS09545 ENOG4105CNN ABC, transporter HV352_RS09550 ENOG4108K4C ec 3.1.3.12 HV352_RS09555 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HV352_RS09560 ENOG4108VA4 Universal stress protein HV352_RS09570 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HV352_RS09575 ENOG4107RD7 Flagellar Motor Protein, MotA HV352_RS09580 ENOG4105ER2 Ompa motb domain protein HV352_RS09585 ENOG4105CBS Chea signal transduction histidine kinase HV352_RS09590 ENOG4108V3W Chemotaxis protein, CheW HV352_RS09595 ENOG4107QJT sodium dicarboxylate symporter HV352_RS09600 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS09605 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS09610 ENOG4105BZU Histidine kinase HV352_RS09615 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HV352_RS09620 ENOG4108VYJ response regulator receiver protein HV352_RS09625 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HV352_RS09630 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV352_RS09645 ENOG4105D00 flagellar biosynthetic protein flhB HV352_RS09650 ENOG4105D7B Flagellar biosynthesis protein flha HV352_RS09655 ENOG4105IRD Flagellar protein FlhE HV352_RS09660 ENOG4105CT4 transporter HV352_RS09665 ENOG4105F5H Glycosyl Hydrolase Family 88 HV352_RS09675 ENOG4105C75 arginyL-tRNA synthetase HV352_RS09680 ENOG4106ZCM YecM protein HV352_RS09685 ENOG4106N3A copper homeostasis protein cutc HV352_RS09690 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HV352_RS09700 ENOG4105WJG Glutathione HV352_RS09705 ENOG41081XQ Conserved Protein HV352_RS09710 ENOG4105D3W isochorismatase HV352_RS09715 ENOG4105C9M aspartyl-trna synthetase HV352_RS09720 ENOG4108TIT dATP pyrophosphohydrolase HV352_RS09725 ENOG4105CDY transcriptional regulatory protein HV352_RS09730 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HV352_RS09740 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HV352_RS09745 ENOG4107QTF adenylosuccinate lyase HV352_RS09755 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HV352_RS09770 ENOG4108HMX isocitrate dehydrogenase (NADP) HV352_RS09775 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV352_RS09780 ENOG4105J4Q Transcriptional regulator HV352_RS09785 ENOG4105TIK HV352_RS09790 ENOG4107BVS HV352_RS09795 ENOG4105Q3Y exported protein HV352_RS09810 ENOG4105CJN penicillin-binding protein HV352_RS09815 ENOG4105DHI Methyltransferase HV352_RS09825 ENOG4108NK4 UPF0266 membrane protein HV352_RS09830 ENOG4105F3R pts system mannose fructose sorbose family iid HV352_RS09835 ENOG4105ETZ PTS System HV352_RS09840 ENOG4105DAS pts system HV352_RS09845 ENOG4105EE5 Membrane protein terC HV352_RS09850 ENOG4107XTP (EAL) domain protein HV352_RS09855 ENOG4105EJQ L-serine dehydratase HV352_RS09865 ENOG4105CRQ synthase (Component I) HV352_RS09870 ENOG4105X5C UPF0181 protein HV352_RS09875 ENOG4105M4H endoribonuclease L-psp HV352_RS09880 ENOG4105DVT helicase HV352_RS09885 ENOG41072GX Peptidase M22 Glycoprotease HV352_RS09890 ENOG4105Y4Z Outer Membrane Lipoprotein HV352_RS09895 ENOG4105CEY Amp-dependent synthetase and ligase HV352_RS09900 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV352_RS09905 ENOG4105E3J oxidoreductase HV352_RS09910 ENOG4105DVW rieske (2Fe-2S) HV352_RS09915 ENOG4105C94 Transporter HV352_RS09920 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV352_RS09925 ENOG4105EJC lysr family transcriptional regulator HV352_RS09935 ENOG4107QMS site-determining protein HV352_RS09945 ENOG4105VNG YcgL domain-containing protein HV352_RS09950 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV352_RS09955 ENOG4108ZZ3 UPF0260 protein HV352_RS09965 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV352_RS09980 ENOG4105ED1 spovr family HV352_RS09985 ENOG4105MWK D-amino acid dehydrogenase, small subunit HV352_RS09990 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV352_RS10000 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV352_RS10010 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HV352_RS10025 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV352_RS10030 ENOG4108BSC Methyltransferase HV352_RS10035 ENOG4105E0A ABC, transporter HV352_RS10040 ENOG4105EHG Permease protein HV352_RS10045 ENOG4105S10 periplasmic binding protein HV352_RS10050 ENOG4105E53 ec 3.2.1.28 HV352_RS10060 ENOG4108UTZ Dihydroxyacetone kinase HV352_RS10065 ENOG4105CMT Dihydroxyacetone kinase HV352_RS10070 ENOG4105D82 Glutamate dehydrogenase HV352_RS10095 ENOG4108XDN Transcriptional regulator HV352_RS10100 ENOG4105BZU Histidine kinase HV352_RS10105 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV352_RS10110 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HV352_RS10120 ENOG410738I uncharacterized protein ymgC HV352_RS10130 ENOG4105CGD Nad-dependent epimerase dehydratase HV352_RS10135 ENOG4105EQ2 LysR family Transcriptional regulator HV352_RS10140 ENOG4107SET aldo keto reductase HV352_RS10150 ENOG4105C4X radical SAM domain protein HV352_RS10170 ENOG4105QEK Transcriptional regulator HV352_RS10175 ENOG4105VG5 Membrane HV352_RS10195 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS10200 ENOG4105CT4 transporter HV352_RS10205 ENOG4108HKT sucrose-6-phosphate hydrolase HV352_RS10240 ENOG4105CEY Amp-dependent synthetase and ligase HV352_RS10275 ENOG4105GR3 Histidine kinase HV352_RS10285 ENOG4105ENX hydrolase HV352_RS10290 ENOG4105C3G gtp-binding protein HV352_RS10300 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV352_RS10305 ENOG4105CFH Aspartokinase HV352_RS10310 ENOG4108JPW Aminotransferase HV352_RS10315 ENOG4105DY8 decarboxylase HV352_RS10320 ENOG4105CHH sulfate transporter HV352_RS10325 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV352_RS10335 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HV352_RS10340 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HV352_RS10345 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HV352_RS10350 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HV352_RS10355 ENOG4108YY7 Invasion gene expression up-regulator SirB HV352_RS10360 ENOG41063JG Transcriptional regulator HV352_RS10370 ENOG4105EWV Sodium calcium exchanger membrane region HV352_RS10375 ENOG4105WS7 Cation transport regulator HV352_RS10380 ENOG4108NH8 Cation transport protein HV352_RS10390 ENOG41090EX DsrE family HV352_RS10395 ENOG4105ID0 Putative invasin HV352_RS10400 ENOG4105WH1 Two component transcriptional regulator luxr family HV352_RS10405 ENOG4105BZU Histidine kinase HV352_RS10410 ENOG4105DQQ Major facilitator superfamily MFS_1 HV352_RS10415 ENOG4105CRU nitrate reductase, alpha subunit HV352_RS10420 ENOG4108IUE nitrate reductase beta subunit HV352_RS10425 ENOG4105R3A Nitrate reductase HV352_RS10430 ENOG41076YT nitrate reductase, gamma subunit HV352_RS10465 ENOG4105CIY formyltetrahydrofolate deformylase HV352_RS10475 ENOG4105D78 K07001 NTE family protein HV352_RS10480 ENOG4105I93 response regulator HV352_RS10485 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV352_RS10495 ENOG4107104 thymidine kinase HV352_RS10500 ENOG4105C0A alcohol dehydrogenase HV352_RS10505 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV352_RS10510 ENOG4107QSI ABC, transporter HV352_RS10515 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV352_RS10520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV352_RS10525 ENOG4105C3U ABC transporter HV352_RS10530 ENOG4108JQ7 (ABC) transporter HV352_RS10535 ENOG4105EYW Ion transport protein HV352_RS10545 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HV352_RS10555 ENOG4105K9H YciI-like protein HV352_RS10575 ENOG410822N TonB family HV352_RS10580 ENOG4105NAU thioesterase Superfamily protein HV352_RS10585 ENOG4107835 probably involved in intracellular septation (By similarity) HV352_RS10590 ENOG4108S3I UPF0259 membrane protein HV352_RS10595 ENOG4105EIF outer membrane protein W HV352_RS10605 ENOG4105BZU Histidine kinase HV352_RS10610 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HV352_RS10615 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HV352_RS10620 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV352_RS10625 ENOG4108EFP Anthranilate synthase component II HV352_RS10630 ENOG4105CRQ synthase (Component I) HV352_RS10640 ENOG4105DB7 PHP domain protein HV352_RS10645 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV352_RS10650 ENOG4105FE9 pseudouridine synthase HV352_RS10655 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV352_RS10660 ENOG4105UBK short-chain dehydrogenase reductase HV352_RS10665 ENOG4105ERU peptidase HV352_RS10670 ENOG4105RKX Protein of unknown function (DUF2498) HV352_RS10675 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV352_RS10680 ENOG4107R11 Transcriptional regulator HV352_RS10695 ENOG4107QM5 aconitate hydratase HV352_RS10705 ENOG4105EYK Phosphatidylglycerophosphatase B HV352_RS10710 ENOG4105Q4A inner membrane protein yciS HV352_RS10715 ENOG4105CFV Tetratricopeptide repeat protein HV352_RS10725 ENOG4108ZJT translation initiation factor, Sui1 HV352_RS10735 ENOG4105N2W Transcriptional regulator HV352_RS10740 ENOG4106BSC UPF0509 protein HV352_RS10745 ENOG4105BZU Histidine kinase HV352_RS10755 ENOG4105Q4T oxidoreductase HV352_RS10760 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV352_RS10770 ENOG4108JQ2 peptide transport system atp-binding protein HV352_RS10775 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV352_RS10780 ENOG4108EU3 peptide transport system, permease HV352_RS10785 ENOG4108EKA peptide transport system, permease HV352_RS10790 ENOG4108J59 Extracellular solute-binding protein, family 5 HV352_RS10795 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV352_RS10800 ENOG4105E51 psp operon transcriptional activator HV352_RS10805 ENOG41087YS Phage shock protein A HV352_RS10810 ENOG4105YYT phage shock protein B HV352_RS10815 ENOG4105FM1 phage shock protein C HV352_RS10820 ENOG4105NNG Peripheral inner membrane phage-shock protein HV352_RS10825 ENOG4107QW3 Sucrose phosphorylase HV352_RS10830 ENOG4105WEM extracellular solute-binding protein HV352_RS10835 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HV352_RS10840 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HV352_RS10845 ENOG4107RRD Dehydrogenase HV352_RS10850 ENOG4107TYA transient receptor potential locus HV352_RS10855 ENOG4105CK5 oxidoreductase HV352_RS10860 ENOG4105C71 hydrolase family 65, central catalytic HV352_RS10865 ENOG4107URF beta-phospho-glucomutase HV352_RS10875 ENOG4107EFV Outer membrane protein G HV352_RS10880 ENOG4105FKQ transcriptional regulator HV352_RS10885 ENOG4105K8Z Phage shock protein HV352_RS10890 ENOG4105CM6 amino acid regulated cytosolic protein HV352_RS10895 ENOG4106K28 UPF0283 membrane protein HV352_RS10905 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV352_RS10910 ENOG4107S8C mandelate racemase muconate lactonizing HV352_RS10915 ENOG4105KXI murein peptide amidase A HV352_RS10920 ENOG4107QSI ABC, transporter HV352_RS10925 ENOG4105MVE transcriptional regulator HV352_RS10930 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HV352_RS10945 ENOG4105D64 Mechanosensitive ion channel HV352_RS10950 ENOG4105S5I Membrane HV352_RS10955 ENOG4105Q9Y Universal stress protein HV352_RS10960 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV352_RS10965 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV352_RS10970 ENOG4108DG9 Smr protein MutS2 HV352_RS10975 ENOG4105BZU Histidine kinase HV352_RS10985 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS11000 ENOG4105C1J atp-dependent rna helicase HV352_RS11005 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HV352_RS11010 ENOG4108RW8 Universal stress protein F HV352_RS11020 ENOG4105FCK Membrane HV352_RS11025 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV352_RS11030 ENOG4105IKK cytoplasmic protein HV352_RS11035 ENOG41090X5 Heat shock protein hslJ HV352_RS11040 ENOG4105C5I Dehydrogenase HV352_RS11045 ENOG4107H52 Dicarboxylate transport HV352_RS11050 ENOG410689M (LipO)protein HV352_RS11055 ENOG4105WXT Conserved Protein HV352_RS11065 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HV352_RS11070 ENOG4105CQ7 ATP-dependent helicase HV352_RS11075 ENOG4107DB1 DUF218 domain HV352_RS11080 ENOG4105C26 Dehydrogenase HV352_RS11085 ENOG4105CPW cytochrome b561 HV352_RS11090 ENOG4105KT5 UmuD protein HV352_RS11095 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV352_RS11100 ENOG4105D6F Phosphatase HV352_RS11115 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS11120 ENOG4105DDW LysR family Transcriptional regulator HV352_RS11125 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HV352_RS11130 ENOG4105E32 cytoplasmic protein HV352_RS11140 ENOG4105Z2P Protein of unknown function (DUF465) HV352_RS11145 ENOG4108Z9I -acetyltransferase HV352_RS11150 ENOG4107WE3 acetyltransferase YdcK HV352_RS11155 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HV352_RS11160 ENOG41088CC tellurite resistance protein tehB HV352_RS11165 ENOG4108KKZ (LipO)protein HV352_RS11180 ENOG4105DKK Benzoate HV352_RS11185 ENOG4108JCI Transcriptional regulator HV352_RS11190 ENOG4105CFP Peptidase U32 HV352_RS11195 ENOG4105RR0 Protein of unknown function (DUF2554) HV352_RS11205 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV352_RS11210 ENOG4105C4M (Ubiquinol oxidase) subunit I HV352_RS11220 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HV352_RS11225 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV352_RS11230 ENOG4107TYH extracellular solute-binding protein family 1 HV352_RS11235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV352_RS11240 ENOG4105D81 ABC transporter, permease HV352_RS11245 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HV352_RS11250 ENOG4105C26 Dehydrogenase HV352_RS11255 ENOG4105C2C drug resistance transporter, Bcr CflA HV352_RS11270 ENOG410654E Membrane HV352_RS11290 ENOG4105DEF Extracellular solute-binding protein, family 5 HV352_RS11295 ENOG4105R71 cytoplasmic protein HV352_RS11300 ENOG4108T9Y Inner membrane protein ydcZ HV352_RS11305 ENOG4108Z7F N-acetyltransferase HV352_RS11315 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV352_RS11320 ENOG4105CHB tonB-dependent Receptor HV352_RS11325 ENOG4108NS2 receptor HV352_RS11330 ENOG4105SUV lipoprotein YgdR HV352_RS11335 ENOG4105C85 amino acid HV352_RS11340 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV352_RS11345 ENOG4105DEN Luciferase family HV352_RS11360 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV352_RS11375 ENOG4105CDA abc transporter atp-binding protein HV352_RS11380 ENOG4108N27 Glutathione S-transferase HV352_RS11385 ENOG4105DJB Major Facilitator Superfamily HV352_RS11390 ENOG4105DIA mandelate racemase muconate lactonizing HV352_RS11395 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS11405 ENOG4108MEJ flavin reductase domain protein HV352_RS11410 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV352_RS11415 ENOG4105JAB phenazine biosynthesis protein, phzf family HV352_RS11420 ENOG4105D0D Nitrate reductase 2, gamma subunit HV352_RS11425 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HV352_RS11430 ENOG4108IUE nitrate reductase beta subunit HV352_RS11435 ENOG4105CRU nitrate reductase, alpha subunit HV352_RS11440 ENOG4107QND Nitrite extrusion protein HV352_RS11460 ENOG4105FCK Membrane HV352_RS11475 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV352_RS11480 ENOG4108MG3 formate dehydrogenase HV352_RS11490 ENOG4107R1I NAD-dependent malic enzyme HV352_RS11495 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HV352_RS11500 ENOG4108Z9K Osmotically inducible protein HV352_RS11505 ENOG4105DTD Dehydrogenase HV352_RS11510 ENOG4105CY2 Citrate transporter HV352_RS11520 ENOG4105CHU acetyl-coa acetyltransferase HV352_RS11525 ENOG4107QNJ CoA-transferase subunit B HV352_RS11530 ENOG4107QP7 CoA-transferase subunit A HV352_RS11535 ENOG4105DUM transcriptional regulator, lysR family HV352_RS11540 ENOG4107H6U ABC transporter HV352_RS11545 ENOG4105C3U ABC transporter HV352_RS11550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV352_RS11555 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV352_RS11560 ENOG4105DEF Extracellular solute-binding protein, family 5 HV352_RS11565 ENOG4108UQS dipeptidase HV352_RS11575 ENOG4105XXV Acid-resistance protein HV352_RS11580 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS11585 ENOG4105F32 YngK protein HV352_RS11590 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HV352_RS11610 ENOG4105FFC UPF0187 protein HV352_RS11625 ENOG4105M0C cytoplasmic protein HV352_RS11630 ENOG4105CSV Glutaminase HV352_RS11635 ENOG4105C26 Dehydrogenase HV352_RS11640 ENOG4105EGI Transcriptional regulator HV352_RS11645 ENOG4105F27 Major Facilitator HV352_RS11655 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV352_RS11660 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV352_RS11665 ENOG4106DNR multiple antibiotic resistance protein HV352_RS11670 ENOG4108594 Permease of the drug metabolite transporter HV352_RS11675 ENOG4105E5W Transporter HV352_RS11680 ENOG4108IV0 ABC, transporter HV352_RS11685 ENOG4108JJB ABC transporter HV352_RS11690 ENOG4105CNN ABC, transporter HV352_RS11710 ENOG4105DGW oligopeptidase A HV352_RS11715 ENOG4105EMU Dehydrogenase HV352_RS11720 ENOG4107XBN GntR Family Transcriptional Regulator HV352_RS11725 ENOG41061EV selenium-binding protein YdfZ HV352_RS11730 ENOG4105DEI Mannitol dehydrogenase HV352_RS11740 ENOG4105CXK mandelate racemase muconate lactonizing HV352_RS11745 ENOG4105KK4 UPF0060 membrane protein HV352_RS11750 ENOG4105M5Q UPF0482 protein HV352_RS11755 ENOG4108MK9 spermidine N(1)-acetyltransferase HV352_RS11765 ENOG4105KBG Protein of unknown function (DUF1161) HV352_RS11770 ENOG4105C3J Cysteine desulfurase HV352_RS11775 ENOG4105QAX Iron-sulfur HV352_RS11780 ENOG4107KGK dmso reductase anchor subunit HV352_RS11785 ENOG4108NEM leader-binding protein dmsD HV352_RS11790 ENOG4105CMQ Chloride channel HV352_RS11795 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV352_RS11800 ENOG4105DAG ROK family HV352_RS11805 ENOG4106NZI LysR family Transcriptional regulator HV352_RS11810 ENOG4105D94 Major Facilitator Superfamily HV352_RS11820 ENOG4105ES5 Histidine kinase HV352_RS11825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV352_RS11835 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HV352_RS11840 ENOG4105CTD carboxy-peptidase HV352_RS11850 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV352_RS11860 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HV352_RS11865 ENOG4105DSF transport protein HV352_RS11870 ENOG4105C2C drug resistance transporter, Bcr CflA HV352_RS11875 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV352_RS11880 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV352_RS11885 ENOG4105C5D exported protein HV352_RS11890 ENOG4105D5Q Arginine ornithine antiporter HV352_RS11895 ENOG410642E Short chain dehydrogenase HV352_RS11900 ENOG4105RA2 Membrane HV352_RS11905 ENOG4107EXC regulatoR HV352_RS11930 ENOG4105JJR Histidine kinase HV352_RS11935 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HV352_RS11940 ENOG4105C9Q fumarate hydratase class II HV352_RS11945 ENOG4107GFK fumarate HV352_RS11950 ENOG4105EIP mannose-6-phosphate isomerase HV352_RS11955 ENOG4106J39 exported protein HV352_RS11960 ENOG4107P2S Transcriptional regulator HV352_RS11965 ENOG4105CI1 PTS System HV352_RS11970 ENOG4105C87 Aminotransferase class I and II HV352_RS11980 ENOG4105D9R oxidoreductase HV352_RS11985 ENOG4106C6R beta-lactam resistance protein HV352_RS11990 ENOG4105QZ5 OriC-binding nucleoid-associated protein HV352_RS11995 ENOG4105M9B inner membrane protein ydgK HV352_RS12005 ENOG4108R3D Electron transport complex HV352_RS12015 ENOG4105D6A Electron transport complex HV352_RS12020 ENOG4108UQQ Electron transport complex HV352_RS12025 ENOG4105DZB Electron transport complex HV352_RS12030 ENOG4105CSM endonuclease III HV352_RS12035 ENOG4105DUX Transporter HV352_RS12040 ENOG4108K3A Glutathione S-transferase HV352_RS12045 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV352_RS12050 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HV352_RS12060 ENOG410642K Lysozyme inhibitor HV352_RS12070 ENOG4108XTF Outer Membrane Lipoprotein HV352_RS12085 ENOG4105Y49 secretion protein, HlyD family HV352_RS12090 ENOG4105DSW Fusaric acid resistance protein HV352_RS12095 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV352_RS12100 ENOG4107RGM aldo keto reductase HV352_RS12105 ENOG4105XZD Fe-S protein HV352_RS12110 ENOG4108WUH Transcriptional regulator, TetR family HV352_RS12115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV352_RS12120 ENOG4108UYE Lactoylglutathione lyase HV352_RS12125 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV352_RS12130 ENOG4105M2J Glutaredoxin HV352_RS12135 ENOG4105K4H Nlp p60 protein HV352_RS12140 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV352_RS12145 ENOG4105F27 Major Facilitator HV352_RS12155 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS12160 ENOG4105F52 Transcriptional regulator HV352_RS12165 ENOG4105CZQ inner membrane transport protein YdhC HV352_RS12170 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV352_RS12175 ENOG4108R6K riboflavin synthase, subunit alpha HV352_RS12185 ENOG4105D3G Pseudouridine synthase HV352_RS12190 ENOG4105JAB phenazine biosynthesis protein, phzf family HV352_RS12195 ENOG4105N0V mono-oxygenase ydhR HV352_RS12200 ENOG4105KME endoribonuclease L-psp HV352_RS12225 ENOG4105BZU Histidine kinase HV352_RS12230 ENOG4107SEY Conserved Protein HV352_RS12235 ENOG4105F4G Membrane HV352_RS12255 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HV352_RS12270 ENOG4105CBP Major Facilitator HV352_RS12285 ENOG4105VSH 4-oxalocrotonate tautomerase HV352_RS12295 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV352_RS12310 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV352_RS12320 ENOG4105EQ2 LysR family Transcriptional regulator HV352_RS12325 ENOG4105ENX hydrolase HV352_RS12330 ENOG4107RTG Major Facilitator superfamily HV352_RS12350 ENOG4108V06 Glutathione peroxidase HV352_RS12365 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HV352_RS12370 ENOG4108W0P ABC transporter HV352_RS12375 ENOG4105EHG Permease protein HV352_RS12380 ENOG4105S10 periplasmic binding protein HV352_RS12385 ENOG4108JPW Aminotransferase HV352_RS12410 ENOG4105C26 Dehydrogenase HV352_RS12425 ENOG4105C85 amino acid HV352_RS12435 ENOG4105CT1 (ABC) transporter HV352_RS12445 ENOG4105E5Q amino acid AbC transporter HV352_RS12450 ENOG4105DRP amino acid AbC transporter HV352_RS12455 ENOG4108Y7C Conserved Protein HV352_RS12460 ENOG4108NWD Cytochrome HV352_RS12465 ENOG4108393 oxidoreductase Fe-S subunit HV352_RS12470 ENOG4105JVW HV352_RS12475 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HV352_RS12480 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HV352_RS12485 ENOG4105RFR Protein of unknown function (DUF2767) HV352_RS12490 ENOG4108ZXC Two component transcriptional regulator, luxr family HV352_RS12495 ENOG4106AFQ Histidine kinase HV352_RS12500 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV352_RS12505 ENOG4106WHD Tetrathionate reductase HV352_RS12510 ENOG4105DB1 molybdopterin oxidoreductase HV352_RS12515 ENOG4105D01 (LipO)protein HV352_RS12520 ENOG4108UMI ABC transporter, permease HV352_RS12530 ENOG4105CA9 Pyruvate kinase HV352_RS12540 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV352_RS12550 ENOG4105C9B Cysteine desulfurase HV352_RS12555 ENOG4105JRK feS assembly protein SufD HV352_RS12560 ENOG4105C3K feS assembly ATPase SufC HV352_RS12565 ENOG4105DIW FeS assembly protein SUFB HV352_RS12570 ENOG4108Z4V iron-sulfur cluster assembly HV352_RS12585 ENOG4105EXG Transcriptional regulator HV352_RS12595 ENOG410671Z uncharacterized protein ydiH HV352_RS12600 ENOG4105KA0 thioesterase Superfamily protein HV352_RS12605 ENOG4105CQB FAD linked oxidase domain protein HV352_RS12610 ENOG4105IPI Membrane HV352_RS12620 ENOG4105SUA Ydil protein HV352_RS12625 ENOG4105EMV Major Facilitator HV352_RS12630 ENOG4105EMV Major Facilitator HV352_RS12645 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HV352_RS12650 ENOG4105C1G acyl-Coa dehydrogenase HV352_RS12655 ENOG4105W4W Transcriptional regulator HV352_RS12660 ENOG4105CV7 Electron transfer flavoprotein HV352_RS12665 ENOG4105C10 Electron transfer flavoprotein HV352_RS12670 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV352_RS12675 ENOG41090P5 ferredoxin-like protein HV352_RS12680 ENOG4105CEY Amp-dependent synthetase and ligase HV352_RS12685 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV352_RS12695 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV352_RS12705 ENOG4107ENK receptor HV352_RS12710 ENOG4106QJH hemin transport protein HV352_RS12715 ENOG4107R4I Periplasmic binding protein HV352_RS12720 ENOG4105EHG Permease protein HV352_RS12725 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV352_RS12740 ENOG4108QBX (LipO)protein HV352_RS12745 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HV352_RS12750 ENOG4108V06 Glutathione peroxidase HV352_RS12765 ENOG4108RVA ribokinase HV352_RS12770 ENOG4108NFH Sugar hydrolase HV352_RS12780 ENOG4105D9N nucleoside HV352_RS12785 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV352_RS12810 ENOG41082NX 50s ribosomal protein l35 HV352_RS12815 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV352_RS12830 ENOG4108NE3 Salt-induced outer membrane protein HV352_RS12835 ENOG4105DE4 1-phosphofructokinase HV352_RS12845 ENOG4107PN8 YfeABCD locus regulator HV352_RS12850 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV352_RS12860 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV352_RS12865 ENOG4108ETY sodium dicarboxylate symporter HV352_RS12870 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HV352_RS12875 ENOG4105CH6 catalase HV352_RS12880 ENOG410901P UPF0249 protein HV352_RS12885 ENOG4105F8D glycoside hydrolase family 4 HV352_RS12890 ENOG4105EZV Transcriptional regulator HV352_RS12895 ENOG4105VCP PTS System HV352_RS12900 ENOG4105CK1 PTS System HV352_RS12905 ENOG4105VZJ PTS System HV352_RS12910 ENOG4105KKI DNA-binding transcriptional activator OsmE HV352_RS12915 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HV352_RS12920 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV352_RS12925 ENOG41090B9 response to stress HV352_RS12930 ENOG4108SPG Periplasmic Protein HV352_RS12945 ENOG4105C26 Dehydrogenase HV352_RS12955 ENOG4105C8Y Acetylornithine aminotransferase HV352_RS12960 ENOG4105CGK Exodeoxyribonuclease III HV352_RS12965 ENOG4108RSN SNARE associated Golgi HV352_RS12970 ENOG4108N5C SNARE associated Golgi protein-related protein HV352_RS12975 ENOG4105VNH ABC transporter solute-binding protein HV352_RS12980 ENOG4105CXZ ABC transporter, permease HV352_RS12985 ENOG4108VGW abc transporter atp-binding protein HV352_RS12990 ENOG4107RM6 sulfurtransferase HV352_RS12995 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV352_RS13000 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV352_RS13005 ENOG4105M6F mutator MutT protein HV352_RS13010 ENOG4105MTM Protein of unknown function (DUF1496) HV352_RS13015 ENOG4105D82 Glutamate dehydrogenase HV352_RS13020 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV352_RS13025 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HV352_RS13030 ENOG41069NU Nitroreductase HV352_RS13035 ENOG4105D07 Signal peptide peptidase, SppA HV352_RS13040 ENOG4105HDK L-asparaginase HV352_RS13045 ENOG4108RWI nicotinamidase HV352_RS13050 ENOG4108KUU Inner membrane metabolite transport protein ydjE HV352_RS13055 ENOG4105E98 transcriptional regulator DeoR family HV352_RS13060 ENOG4105CPC Aldo Keto reductase HV352_RS13065 ENOG4107UH8 sugar kinase HV352_RS13070 ENOG4105D2N Aldolase HV352_RS13075 ENOG4105CPQ Dehydrogenase HV352_RS13080 ENOG4107TE1 transport protein HV352_RS13085 ENOG4105CPQ Dehydrogenase HV352_RS13095 ENOG4105N1F Hnh endonuclease HV352_RS13100 ENOG4105VUT cytoplasmic protein HV352_RS13110 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV352_RS13115 ENOG4105DSB aldose 1-epimerase HV352_RS13120 ENOG4105CV8 reductase HV352_RS13135 ENOG4105GNX MltA-interacting MipA family protein HV352_RS13140 ENOG4105CYN Serine protein kinase HV352_RS13150 ENOG4105EQK -acetyltransferase HV352_RS13160 ENOG4105DVA methyltransferase HV352_RS13165 ENOG4108KHP Diguanylate cyclase HV352_RS13170 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV352_RS13175 ENOG4108VMM UPF0756 membrane protein HV352_RS13180 ENOG4105R1U AraC Family Transcriptional Regulator HV352_RS13185 ENOG4105DJ2 Major Facilitator Superfamily HV352_RS13190 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV352_RS13195 ENOG4105K78 MarR family Transcriptional regulator HV352_RS13200 ENOG4105UCG Domain of unknown function (DUF333) HV352_RS13205 ENOG410620I Diguanylate cyclase HV352_RS13210 ENOG4106G4W HV352_RS13220 ENOG4105Y3U Transglycosylase-associated protein HV352_RS13225 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV352_RS13235 ENOG4105YP6 Domain of unknown function (DUF1869) HV352_RS13240 ENOG4108YS1 cytoplasmic protein HV352_RS13245 ENOG4108NIW Leucine export protein LeuE HV352_RS13250 ENOG4108MEK Metal-binding protein YodA HV352_RS13255 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV352_RS13265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV352_RS13275 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HV352_RS13280 ENOG4105D05 Receptor HV352_RS13285 ENOG4105D0M Protease HtpX homolog HV352_RS13290 ENOG4105CN1 protease HV352_RS13295 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HV352_RS13300 ENOG4108ZGC gaf domain protein HV352_RS13305 ENOG4105H2K paraquat-inducible protein a HV352_RS13310 ENOG4105DY2 Paraquat-inducible protein b HV352_RS13315 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HV352_RS13320 ENOG4105WT8 Protein of unknown function (DUF1480) HV352_RS13325 ENOG4105UVW uncharacterized protein yebW HV352_RS13330 ENOG4108R1E Serine threonine protein phosphatase 1 HV352_RS13340 ENOG4108RAV Conserved protein HV352_RS13345 ENOG4107SEY Conserved Protein HV352_RS13365 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV352_RS13380 ENOG4107FW0 short-chain dehydrogenase reductase HV352_RS13390 ENOG4108XDN Transcriptional regulator HV352_RS13400 ENOG4105BZU Histidine kinase HV352_RS13410 ENOG4105C94 Transporter HV352_RS13415 ENOG4105KT5 UmuD protein HV352_RS13425 ENOG4105Y50 Virulence Protein HV352_RS13575 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV352_RS13590 ENOG4108RW8 Universal stress protein F HV352_RS13625 ENOG4107TII Recombinase HV352_RS13635 ENOG4105JBR DNA replication protein HV352_RS13690 ENOG41076J9 exonuclease VIII HV352_RS13705 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 HV352_RS13710 ENOG4108I1J Integrase HV352_RS13715 ENOG4105NKT exported protein HV352_RS13720 ENOG4108PNC copper resistance HV352_RS13725 ENOG4105FXM Copper resistance protein HV352_RS13730 ENOG4105MPK DNA polymerase III subunit theta HV352_RS13735 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV352_RS13740 ENOG4105UMD exodeoxyribonuclease X HV352_RS13745 ENOG4105CUG Oligopeptidase b HV352_RS13750 ENOG4108Q2J Inner membrane protein YebE HV352_RS13760 ENOG4105X2V dna damage-inducible protein HV352_RS13765 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HV352_RS13770 ENOG4108UHU Aldolase HV352_RS13775 ENOG4105C01 Dihydroxy-acid dehydratase HV352_RS13780 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV352_RS13785 ENOG4106KNT transcriptional regulator HV352_RS13790 ENOG4105CA9 Pyruvate kinase HV352_RS13795 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV352_RS13800 ENOG4105DR5 peptidase HV352_RS13805 ENOG4105NXV High-affinity zinc uptake system protein HV352_RS13815 ENOG4105FAV ABC, transporter HV352_RS13825 ENOG4108YDI single-species biofilm formation on inanimate substrate HV352_RS13835 ENOG4108QY0 Membrane HV352_RS13840 ENOG4108WTK competence damage-inducible protein HV352_RS13845 ENOG4108N8X transition metal ion binding HV352_RS13850 ENOG4108Z9Z response to DNA damage stimulus HV352_RS13860 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV352_RS13900 ENOG4105UZW Tail fiber assembly protein HV352_RS13905 ENOG4108X9F tail fiber protein HV352_RS13980 ENOG4105D07 Signal peptide peptidase, SppA HV352_RS13995 ENOG4105CAR Terminase, large subunit HV352_RS14015 ENOG4108VKM cytochrome b561 HV352_RS14060 ENOG4108MXB Protein of unknown function (DUF968) HV352_RS14145 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV352_RS14150 ENOG41076J9 exonuclease VIII HV352_RS14155 ENOG4107160 Rac prophage HV352_RS14160 ENOG4107R08 Integrase HV352_RS14165 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV352_RS14175 ENOG4105EZE Cupin 4 family protein HV352_RS14180 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV352_RS14195 ENOG4105W3V DNA-binding, transcriptional regulator HV352_RS14200 ENOG4105E2V Glycosyltransferase 36 HV352_RS14205 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV352_RS14210 ENOG4106IAW HV352_RS14225 ENOG4105DR8 Membrane HV352_RS14235 ENOG4105VEQ Cold shock protein HV352_RS14250 ENOG4105D38 putrescine abc transporter HV352_RS14255 ENOG4108HM4 ABC transporter HV352_RS14260 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV352_RS14270 ENOG4105D60 lipoprotein releasing system transmembrane protein HV352_RS14275 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV352_RS14280 ENOG4105D60 lipoprotein releasing system transmembrane protein HV352_RS14285 ENOG4105IQC Inner membrane protein YcfT HV352_RS14290 ENOG4108JA2 transcriptioN-repair coupling factor HV352_RS14295 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV352_RS14300 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV352_RS14305 ENOG4108IND Tetr family transcriptional regulator HV352_RS14315 ENOG4107MBR 17 kDa surface antigen HV352_RS14320 ENOG4105CEP NADH dehydrogenase HV352_RS14335 ENOG4108RUM thiamine kinase HV352_RS14340 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV352_RS14345 ENOG41090DQ Lipoprotein HV352_RS14350 ENOG4105K59 histidine triad (HIT) protein HV352_RS14355 ENOG4105CNM Receptor HV352_RS14365 ENOG4105UQX Mate efflux family protein HV352_RS14400 ENOG4107R11 Transcriptional regulator HV352_RS14420 ENOG4105CSH Transporter HV352_RS14425 ENOG4105FYV Amp nucleosidase HV352_RS14430 ENOG4105DC7 peptidase M24 HV352_RS14435 ENOG4105CI1 PTS System HV352_RS14440 ENOG4105F8V Hydrolase, tatD family HV352_RS14445 ENOG4107QRG dna polymerase iii HV352_RS14450 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HV352_RS14455 ENOG4105HHA aminodeoxychorismate lyase HV352_RS14460 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV352_RS14465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV352_RS14470 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV352_RS14475 ENOG4105CHR reductase HV352_RS14480 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV352_RS14485 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV352_RS14490 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HV352_RS14495 ENOG4105VGS 50s ribosomal protein l32 HV352_RS14500 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV352_RS14510 ENOG4105EI2 Pseudouridine synthase HV352_RS14515 ENOG4107QQB Ribonuclease E HV352_RS14520 ENOG4105DTJ flagellar hook-associated protein HV352_RS14525 ENOG4105E1Q flagellar hook-associated protein HV352_RS14530 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV352_RS14535 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HV352_RS14545 ENOG4105CGA flagellar basal-body rod protein FlgG HV352_RS14550 ENOG4108KPB Flagellar basal-body rod protein FlgF HV352_RS14555 ENOG4105BZE flagellar hook protein, FlgE HV352_RS14560 ENOG4105W00 Flagellar hook capping protein HV352_RS14565 ENOG4108ZC9 flagellar basal-body rod protein flgc HV352_RS14570 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HV352_RS14575 ENOG4105CKS Flagella basal body P-ring formation protein flgA HV352_RS14580 ENOG4105M9M anti-sigma28 factor FlgM HV352_RS14585 ENOG4105QVD Flagella synthesis protein FlgN HV352_RS14590 ENOG4105CJR Integral membrane protein (MviN HV352_RS14595 ENOG4105EP9 oxidoreductase HV352_RS14605 ENOG4105D9U N-acetyltransferase HV352_RS14610 ENOG4105EV4 Multidrug resistance protein mdtH HV352_RS14615 ENOG4105F3T (LipO)protein HV352_RS14620 ENOG4105EKE dihydroorotase HV352_RS14625 ENOG4105MEA DNA damage-inducible protein i HV352_RS14630 ENOG4105PVA Biofilm formation regulatory protein BssS HV352_RS14635 ENOG4105F76 Sarcosine oxidase HV352_RS14640 ENOG4106974 biofilm formation HV352_RS14645 ENOG4105DS1 cytochrome b561 HV352_RS14650 ENOG4108YYC ycei family HV352_RS14660 ENOG4105D1S lipid A biosynthesis HV352_RS14665 ENOG4105C6X Major Facilitator HV352_RS14670 ENOG4108W47 Acidic protein msyB HV352_RS14675 ENOG4105NAC (LipO)protein HV352_RS14680 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HV352_RS14695 ENOG4107RZC phospholipase d HV352_RS14700 ENOG4108UVJ appr-1-p processing domain protein HV352_RS14705 ENOG41068SS HV352_RS14710 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HV352_RS14715 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HV352_RS14720 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HV352_RS14725 ENOG41086KC Transcriptional regulator HV352_RS14730 ENOG4108XDW curli assembly protein CsgE HV352_RS14735 ENOG4108WYR Curli production assembly transport component, CsgF HV352_RS14740 ENOG4105P8Q Curli production assembly transport component CsgG HV352_RS14745 ENOG4108UQ5 membrane protein YcdZ HV352_RS14750 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV352_RS14755 ENOG4107SSZ Phosphatase HV352_RS14760 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HV352_RS14775 ENOG4105D5M phosphate starvation-inducible protein HV352_RS14780 ENOG4105DBE peroxidase HV352_RS14795 ENOG4105CK7 Sodium proline symporter HV352_RS14800 ENOG4105C26 Dehydrogenase HV352_RS14805 ENOG4105VTN Protein of unknown function (DUF1311) HV352_RS14810 ENOG4108R86 Transcriptional regulator HV352_RS14820 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV352_RS14825 ENOG4105CS1 NAD(P)H quinone oxidoreductase HV352_RS14830 ENOG4105XH3 HV352_RS14835 ENOG4105D6F Phosphatase HV352_RS14840 ENOG4108ZHR arsR family transcriptional regulator HV352_RS14850 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV352_RS14855 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV352_RS14870 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HV352_RS14875 ENOG4108Z33 Thiol disulfide Interchange Protein HV352_RS14880 ENOG4105DVC DnaJ domain protein HV352_RS14905 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type HV352_RS14925 ENOG4105EHG Permease protein HV352_RS14930 ENOG4105E0A ABC, transporter HV352_RS14945 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HV352_RS14960 ENOG4108J59 Extracellular solute-binding protein, family 5 HV352_RS14965 ENOG4108MN8 Membrane HV352_RS15005 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HV352_RS15010 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV352_RS15025 ENOG4105K4P CoA-binding domain protein HV352_RS15030 ENOG4108Q67 UPF0319 protein HV352_RS15035 ENOG4108Z5K methylglyoxal synthase HV352_RS15040 ENOG41088T4 Helicase IV HV352_RS15045 ENOG410901E Membrane HV352_RS15050 ENOG4105EM2 membrane HV352_RS15055 ENOG4108RZ1 DNA transformation protein HV352_RS15065 ENOG4105UYK outer membrane protein a HV352_RS15070 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HV352_RS15075 ENOG4105DAN ATP-dependent protease HV352_RS15085 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV352_RS15090 ENOG4108Q2G (LipO)protein HV352_RS15095 ENOG4105DY2 Paraquat-inducible protein b HV352_RS15100 ENOG4105F1S paraquat-inducible protein a HV352_RS15105 ENOG4105C5H ABC transporter HV352_RS15110 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HV352_RS15115 ENOG4105QVC MOSC domain-containing protein HV352_RS15120 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV352_RS15130 ENOG4108UZX fmn reductase HV352_RS15135 ENOG4105GVF (ABC) transporter HV352_RS15140 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HV352_RS15145 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV352_RS15155 ENOG4105CD8 aminopeptidase N HV352_RS15160 ENOG4107RH7 Nicotinate phosphoribosyltransferase HV352_RS15175 ENOG4105CGF Aromatic amino acid aminotransferase HV352_RS15180 ENOG4105C5X domain protein HV352_RS15185 ENOG4105EAQ (twin-arginine translocation) pathway signal HV352_RS15190 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV352_RS15195 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HV352_RS15200 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV352_RS15210 ENOG4106371 Methyltransferase HV352_RS15215 ENOG4107S90 membrAne HV352_RS15220 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV352_RS15225 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HV352_RS15235 ENOG4105T0Z Conserved Protein HV352_RS15240 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HV352_RS15245 ENOG4105BZ1 (ABC) transporter HV352_RS15250 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV352_RS15255 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV352_RS15260 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV352_RS15265 ENOG4105CAT Cytidine monophosphate kinase HV352_RS15270 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HV352_RS15275 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HV352_RS15280 ENOG4107VMU Membrane HV352_RS15285 ENOG4105DDY UPF0142 protein ycaO HV352_RS15290 ENOG4105TMB Formate nitrite transporter HV352_RS15295 ENOG4105C6N Formate acetyltransferase HV352_RS15300 ENOG4105F1A Pyruvate formate-lyase HV352_RS15320 ENOG4108HHA Transketolase HV352_RS15330 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV352_RS15335 ENOG4108ISG Major Facilitator HV352_RS15340 ENOG4105CHJ isochorismatase hydrolase HV352_RS15345 ENOG4107KGK dmso reductase anchor subunit HV352_RS15350 ENOG4105QAX Iron-sulfur HV352_RS15355 ENOG4107QY8 reductase HV352_RS15360 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HV352_RS15365 ENOG4105D1H recombination factor protein RarA HV352_RS15375 ENOG4105CNU cell division protein FtsK HV352_RS15380 ENOG4105EW9 transcriptional regulator AsnC family HV352_RS15385 ENOG4105C3M thioredoxin reductase HV352_RS15390 ENOG4108JJ9 ABC, transporter HV352_RS15395 ENOG4108JJ8 (ABC) transporter HV352_RS15400 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HV352_RS15415 ENOG4105CC0 LysR family Transcriptional regulator HV352_RS15420 ENOG4105EUB pirin domain protein HV352_RS15425 ENOG4105CHJ isochorismatase hydrolase HV352_RS15435 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HV352_RS15440 ENOG4105RBQ inner membrane protein ybjO HV352_RS15445 ENOG4105D38 putrescine abc transporter HV352_RS15450 ENOG4105F38 ABC transporter, permease HV352_RS15455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV352_RS15460 ENOG4107RUE extracellular solute-binding protein family 1 HV352_RS15465 ENOG4108RMJ sensory transduction regulator HV352_RS15470 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HV352_RS15475 ENOG4108DBC nitroreductase HV352_RS15480 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HV352_RS15485 ENOG41090BQ Glutaredoxin HV352_RS15490 ENOG4105GWF inner membrane protein YbjM HV352_RS15495 ENOG4105D0C transport protein HV352_RS15520 ENOG4105UZW Tail fiber assembly protein HV352_RS15525 ENOG4108X9F tail fiber protein HV352_RS15615 ENOG4105ED4 portal protein HV352_RS15630 ENOG4105VZ1 Replication Protein HV352_RS15640 ENOG4105DFE Dna adenine methylase HV352_RS15690 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV352_RS15695 ENOG4105DMW Dehydrogenase reductase HV352_RS15700 ENOG4108RFG Tetr family transcriptional regulator HV352_RS15705 ENOG4106UW1 Major Facilitator superfamily HV352_RS15710 ENOG4108HCJ Hydrolase HV352_RS15720 ENOG4107QF7 multi-drug HV352_RS15725 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV352_RS15730 ENOG4107FB0 transcriptional regulator DeoR family HV352_RS15735 ENOG4105DZ1 carboxypeptidase HV352_RS15740 ENOG4108TGY Glutathione S-transferase HV352_RS15745 ENOG4105D8V Glucose sorbosone dehydrogenase HV352_RS15750 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV352_RS15765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV352_RS15770 ENOG4105DEF Extracellular solute-binding protein, family 5 HV352_RS15775 ENOG4108JQ6 ABC transporter HV352_RS15780 ENOG4105D44 asparaginase HV352_RS15790 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV352_RS15795 ENOG4105D06 uba thif-type nad fad binding protein HV352_RS15800 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV352_RS15805 ENOG4105F1A Pyruvate formate-lyase HV352_RS15815 ENOG4108HCJ Hydrolase HV352_RS15820 ENOG41072TH Protein of unknown function (DUF1479) HV352_RS15825 ENOG4105C5H ABC transporter HV352_RS15830 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV352_RS15835 ENOG4105F4P )-transporter HV352_RS15840 ENOG4105KST dependent repressor HV352_RS15850 ENOG4108I6E Sulfatase HV352_RS15855 ENOG4108T1M outer membrane protein x HV352_RS15865 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HV352_RS15870 ENOG4107R0W ABC transporter HV352_RS15875 ENOG4105E5Q amino acid AbC transporter HV352_RS15880 ENOG4105CDA abc transporter atp-binding protein HV352_RS15885 ENOG4105D8X mechanosensitive ion channel HV352_RS15890 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HV352_RS15895 ENOG4105ZY9 UPF0379 protein ybiM HV352_RS15900 ENOG4108IU3 tonb-dependent siderophore receptor HV352_RS15910 ENOG4105KSC Transcriptional regulator, TraR DksA family HV352_RS15915 ENOG4105VR4 UPF0379 protein ybiJ HV352_RS15920 ENOG4105DG4 malate L-lactate dehydrogenase HV352_RS15925 ENOG4108MTB glycosyl transferase family HV352_RS15930 ENOG4105DVT helicase HV352_RS15935 ENOG4105C1J atp-dependent rna helicase HV352_RS15940 ENOG4107MVR Transcriptional regulator HV352_RS15945 ENOG4105D0S secretion protein (HlyD HV352_RS15950 ENOG4105CJ1 ABC, transporter HV352_RS15955 ENOG4107QWP ABC-2 type transporter HV352_RS15960 ENOG4107QWP ABC-2 type transporter HV352_RS15965 ENOG4105I9U inner membrane protein ybhQ HV352_RS15970 ENOG4105X23 Endonuclease Exonuclease phosphatase HV352_RS15975 ENOG4105DZQ phospholipase D Transphosphatidylase HV352_RS15980 ENOG4107UXM Membrane HV352_RS15985 ENOG4105HFZ Membrane HV352_RS15990 ENOG4108ZAF Molybdopterin HV352_RS15995 ENOG4105M00 molybdopterin converting factor, subunit 1 HV352_RS16000 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HV352_RS16005 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV352_RS16015 ENOG4105CHW UPF0052 protein HV352_RS16020 ENOG4105DFD Na H antiporter HV352_RS16030 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HV352_RS16035 ENOG4108IV0 ABC, transporter HV352_RS16040 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV352_RS16045 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV352_RS16050 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV352_RS16060 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV352_RS16080 ENOG4108V1U phospholipid-binding protein HV352_RS16085 ENOG4105C84 Histidine ammonia-lyase HV352_RS16090 ENOG4105CGP Urocanate hydratase HV352_RS16100 ENOG41088SP formiminoglutamate hydrolase HV352_RS16110 ENOG4105NBR Pectinesterase HV352_RS16115 ENOG4105XB6 Toxin coregulated pilin HV352_RS16130 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C HV352_RS16150 ENOG4107QHF type ii secretion system protein e HV352_RS16155 ENOG4108VEY type ii secretion system HV352_RS16160 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HV352_RS16165 ENOG4105E4C Lytic transglycosylase catalytic HV352_RS16175 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HV352_RS16180 ENOG4108K4B hydrolase HV352_RS16190 ENOG4105E0C molybdate abc transporter HV352_RS16195 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV352_RS16205 ENOG4105F4R Transcriptional regulator mode HV352_RS16210 ENOG4105DKW ABC transporter HV352_RS16215 ENOG4105CMR udp-glucose 4-epimerase HV352_RS16220 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV352_RS16225 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HV352_RS16230 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV352_RS16235 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV352_RS16240 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV352_RS16245 ENOG4105JND homeobox protein HV352_RS16250 ENOG4105PGM cation diffusion facilitator family transporter HV352_RS16255 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV352_RS16295 ENOG4105UFD tol-pal system protein YbgF HV352_RS16300 ENOG4105KCK Peptidoglycan-associated lipoprotein HV352_RS16310 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV352_RS16320 ENOG4105E02 MotA TolQ exbB proton channel HV352_RS16325 ENOG4107YD3 Thioesterase HV352_RS16330 ENOG4105KJB cyd operon protein YbgE HV352_RS16340 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV352_RS16345 ENOG4105C4M (Ubiquinol oxidase) subunit I HV352_RS16350 ENOG4107WFU Glutamate mutase subunit sigma HV352_RS16360 ENOG4105DJI Methylaspartate mutase, E subunit HV352_RS16385 ENOG4105CSV Glutaminase HV352_RS16390 ENOG4107GFK fumarate HV352_RS16395 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV352_RS16400 ENOG4105ETT transcriptional Regulator, LysR family HV352_RS16405 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV352_RS16410 ENOG4107XVH Transcriptional regulator HV352_RS16415 ENOG4105G63 Type III effector Hrp-dependent HV352_RS16425 ENOG4105MVE transcriptional regulator HV352_RS16430 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HV352_RS16455 ENOG4105C8I hydrolase, family 38 HV352_RS16460 ENOG4105DM4 PTS System HV352_RS16465 ENOG4105FDP GntR family transcriptional regulator HV352_RS16470 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV352_RS16475 ENOG4105CMV Succinyl-CoA synthetase subunit beta HV352_RS16480 ENOG4105C7S Dehydrogenase HV352_RS16485 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV352_RS16490 ENOG4105E33 succinate dehydrogenase HV352_RS16495 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV352_RS16500 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV352_RS16505 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV352_RS16510 ENOG4105BZN citrate synthase HV352_RS16515 ENOG4108KK1 membrane protein AbrB duplication HV352_RS16525 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HV352_RS16540 ENOG4105E7W lamb ycsf family protein HV352_RS16545 ENOG4107R7A Allophanate hydrolase subunit 2 HV352_RS16550 ENOG4105P4J Allophanate hydrolase, subunit 1 HV352_RS16555 ENOG4107QNR UPF0135 protein HV352_RS16565 ENOG4105DNE Transposase HV352_RS16570 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV352_RS16575 ENOG4105XIQ Protein of unknown function (DUF2517) HV352_RS16600 ENOG4105C08 Histidine kinase HV352_RS16605 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV352_RS16615 ENOG4105CXN decarboxylase HV352_RS16620 ENOG4105D5Q Arginine ornithine antiporter HV352_RS16625 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV352_RS16630 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV352_RS16635 ENOG4105EV9 Alpha Beta Hydrolase HV352_RS16640 ENOG4105NNH LexA regulated protein HV352_RS16645 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV352_RS16655 ENOG41090R7 Ferric uptake HV352_RS16660 ENOG4106P55 Transcriptional regulator HV352_RS16665 ENOG4107EFR Flavocytochrome c HV352_RS16680 ENOG4105GX6 (LipO)protein HV352_RS16685 ENOG4105J5J Outer membrane porin HV352_RS16690 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS16700 ENOG4105WEM extracellular solute-binding protein HV352_RS16710 ENOG4105CI1 PTS System HV352_RS16720 ENOG4105CE4 GlcNAc 6-P deacetylase HV352_RS16725 ENOG4105E2R ROK family HV352_RS16730 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV352_RS16735 ENOG4105CAQ asparagine synthetase HV352_RS16775 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV352_RS16780 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HV352_RS16785 ENOG4105C9A Phoh family HV352_RS16790 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HV352_RS16795 ENOG4108JU5 Magnesium and cobalt efflux protein HV352_RS16800 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV352_RS16805 ENOG4107RP9 extracellular solute-binding protein, family 3 HV352_RS16810 ENOG4105EAD ABC transporter HV352_RS16815 ENOG4105DRP amino acid AbC transporter HV352_RS16820 ENOG4105CDA abc transporter atp-binding protein HV352_RS16830 ENOG4107PAI alpha helical protein HV352_RS16835 ENOG4105C8T Leucyl-tRNA synthetase HV352_RS16845 ENOG4105DJF DNA polymerase III, delta' subunit HV352_RS16850 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HV352_RS16855 ENOG4107QZB decarboxylase HV352_RS16860 ENOG4108TGR phosphatase HV352_RS16865 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV352_RS16870 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HV352_RS16875 ENOG4105CJN penicillin-binding protein HV352_RS16880 ENOG4105CNI cell division protein FtsW HV352_RS16885 ENOG4105K6T rare lipoprotein A HV352_RS16890 ENOG4105DZ1 carboxypeptidase HV352_RS16895 ENOG4108Z43 UPF0250 protein HV352_RS16900 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HV352_RS16930 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV352_RS16935 ENOG4105CEE C4-dicarboxylate transporter HV352_RS16940 ENOG4106YYS transcriptional regulatory protein HV352_RS16945 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV352_RS16950 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV352_RS16960 ENOG4105CI0 Citrate lyase HV352_RS16965 ENOG4105CHY citrate lyase, alpha HV352_RS16970 ENOG4105YGP holo-ACP synthase CitX HV352_RS16975 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HV352_RS16980 ENOG4107QPK )-transporter HV352_RS16985 ENOG4105KTS ribonuclease HV352_RS17000 ENOG4105NXH GreA GreB family elongation factor HV352_RS17005 ENOG4108U51 Universal stress protein HV352_RS17015 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV352_RS17020 ENOG4108J2R molybdopterin oxidoreductase HV352_RS17030 ENOG4108JU3 Alkyl hydroperoxide reductase HV352_RS17035 ENOG4105D3R alkyl hydroperoxide reductase HV352_RS17040 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV352_RS17045 ENOG4105DQS Transcriptional regulator HV352_RS17050 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV352_RS17055 ENOG4105GTN ParB Domain Protein Nuclease HV352_RS17060 ENOG4105CHM Aminotransferase HV352_RS17065 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV352_RS17070 ENOG4105VCD cytoplasmic protein HV352_RS17075 ENOG4105D22 carbon starvation protein HV352_RS17080 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HV352_RS17085 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV352_RS17090 ENOG4105WQI isochorismatase HV352_RS17095 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV352_RS17100 ENOG4105E4F Isochorismate synthase HV352_RS17105 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV352_RS17110 ENOG4105E8G Major facilitator Superfamily HV352_RS17115 ENOG4105DQ5 transport system permease protein HV352_RS17120 ENOG4105TVJ transport system, permease HV352_RS17125 ENOG4105E0A ABC, transporter HV352_RS17130 ENOG4105C0W non-ribosomal peptide synthetase HV352_RS17135 ENOG41085A6 mbth domain-containing protein HV352_RS17140 ENOG4105E93 esterase HV352_RS17145 ENOG4107RNH Outer membrane receptor FepA HV352_RS17150 ENOG4108TSE Transferase HV352_RS17155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV352_RS17165 ENOG4105C2J ABC transporter HV352_RS17170 ENOG4105CNN ABC, transporter HV352_RS17175 ENOG4105DKT Transcriptional regulator HV352_RS17180 ENOG4108HHA Transketolase HV352_RS17185 ENOG4108IUS Transketolase HV352_RS17195 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV352_RS17205 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HV352_RS17210 ENOG4105WQ6 Membrane HV352_RS17215 ENOG4105HFT AraC family transcriptional regulator HV352_RS17225 ENOG41067SE Tetr family transcriptional regulator HV352_RS17230 ENOG4105MSB protein, conserved in bacteria HV352_RS17235 ENOG4108RCM Nitroreductase HV352_RS17240 ENOG4105CUY Mechanosensitive ion channel HV352_RS17260 ENOG4105EAA nucleoside HV352_RS17265 ENOG4105C85 amino acid HV352_RS17285 ENOG4105BZU Histidine kinase HV352_RS17300 ENOG4108KBJ Inner membrane protein YkgB HV352_RS17305 ENOG41066GK UPF0379 protein ykgI HV352_RS17310 ENOG4107QN2 dihydrolipoyl dehydrogenase HV352_RS17315 ENOG4108K01 transcriptional regulator HV352_RS17320 ENOG4108IJF Heavy metal efflux pump, CzcA HV352_RS17325 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HV352_RS17330 ENOG410624V efflux system protein HV352_RS17335 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV352_RS17340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV352_RS17345 ENOG4105GR3 Histidine kinase HV352_RS17365 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HV352_RS17370 ENOG4107QY8 reductase HV352_RS17375 ENOG4105CUW cytochrome C-TYPE protein HV352_RS17380 ENOG4108RW8 Universal stress protein F HV352_RS17390 ENOG4108EM1 reductase HV352_RS17395 ENOG4105CUW cytochrome C-TYPE protein HV352_RS17400 ENOG4106WF9 DNA-binding transcriptional regulator TorR HV352_RS17405 ENOG4108SV3 Tmao reductase system periplasmic protein tort HV352_RS17410 ENOG4105BZU Histidine kinase HV352_RS17425 ENOG4106KCD HTH_LUXR HV352_RS17430 ENOG4106721 fimbriae Y protein HV352_RS17435 ENOG4108Q9V regulatoR HV352_RS17440 ENOG4108ZI2 Fimbrial protein HV352_RS17445 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HV352_RS17450 ENOG4105CW0 outer membrane usher protein HV352_RS17455 ENOG4108AF8 Chaperone HV352_RS17465 ENOG4108WDE Fimbrial protein HV352_RS17470 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HV352_RS17475 ENOG4105WQ3 Rna-binding protein HV352_RS17480 ENOG4105S2T inner membrane protein YbcI HV352_RS17490 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV352_RS17500 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV352_RS17505 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV352_RS17515 ENOG4108UMI ABC transporter, permease HV352_RS17525 ENOG4105D01 (LipO)protein HV352_RS17535 ENOG4105CV6 ABC transporter, permease HV352_RS17540 ENOG4108I0Y (ABC) transporter HV352_RS17545 ENOG4108UJV acyl-CoA thioesterase i HV352_RS17550 ENOG4105E1F short-chain dehydrogenase reductase HV352_RS17555 ENOG4107QR8 Thioredoxin HV352_RS17560 ENOG4105C4B ABC transporter, permease HV352_RS17565 ENOG41083J0 (ABC) transporter HV352_RS17570 ENOG4107QX8 SPFH domain, Band 7 family protein HV352_RS17575 ENOG4105G5H Membrane HV352_RS17590 ENOG4108Z6Z Transcriptional regulator HV352_RS17600 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV352_RS17605 ENOG4105D4P Coproporphyrinogen iii oxidase HV352_RS17610 ENOG41090JE Utilization Protein HV352_RS17620 ENOG4105EHG Permease protein HV352_RS17625 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV352_RS17630 ENOG4105C59 p-type ATPase HV352_RS17635 ENOG4105MBR gumn family HV352_RS17640 ENOG4108Z66 YbaK ebsC protein HV352_RS17645 ENOG4105CGH 5'-nucleotidase HV352_RS17650 ENOG4105EU0 Major facilitator Superfamily HV352_RS17655 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV352_RS17660 ENOG4107RE1 Inosine-guanosine kinase HV352_RS17675 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HV352_RS17680 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HV352_RS17685 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HV352_RS17690 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HV352_RS17695 ENOG4107QMP dna polymerase iii subunits gamma and tau HV352_RS17700 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HV352_RS17705 ENOG4105WD1 Membrane HV352_RS17710 ENOG4108URS primosomal replication protein n'' HV352_RS17715 ENOG4106428 Protein of unknown function (DUF2496) HV352_RS17720 ENOG4105EGS Mechanosensitive ion channel HV352_RS17725 ENOG4107XI7 Tetr family transcriptional regulator HV352_RS17730 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV352_RS17735 ENOG4105BZS acriflavin resistance protein HV352_RS17740 ENOG4108UKR Biofilm formation regulator YbaJ HV352_RS17750 ENOG4108UW5 maltose o-acetyltransferase HV352_RS17755 ENOG4105GSJ Inner membrane protein ylaC HV352_RS17765 ENOG4105NRA 50s ribosomal protein l31 type b HV352_RS17770 ENOG41066DG (EAL) domain protein HV352_RS17775 ENOG4105KCV RNA signal recognition particle 4.5S RNA HV352_RS17780 ENOG4108VW9 Membrane HV352_RS17785 ENOG4107U9B transcriptional regulator HV352_RS17805 ENOG41080UX Methyltransferase HV352_RS17810 ENOG4108MNP Glycoprotein polysaccharide metabolism HV352_RS17815 ENOG4105C29 acyl-CoA thioesterase HV352_RS17820 ENOG4105BZU Histidine kinase HV352_RS17825 ENOG4108YZA Nitrogen regulatory protein pii HV352_RS17830 ENOG4105BZ1 (ABC) transporter HV352_RS17835 ENOG4105BZ1 (ABC) transporter HV352_RS17840 ENOG4108XM1 transcriptional regulator AsnC family HV352_RS17850 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HV352_RS17855 ENOG4108NFA extracellular solute-binding protein HV352_RS17860 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HV352_RS17865 ENOG4108TGP Thioesterase superfamily protein HV352_RS17870 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV352_RS17875 ENOG4105EIN peptidylprolyl cis-trans isomerase HV352_RS17880 ENOG4105K70 DNA-binding protein HV352_RS17885 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV352_RS17890 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HV352_RS17905 ENOG4105M85 Bola protein HV352_RS17910 ENOG4105IEY (LipO)protein HV352_RS17915 ENOG4105EYM Major Facilitator superfamily HV352_RS17920 ENOG4105E2S oxidase) subunit II HV352_RS17925 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV352_RS17930 ENOG4105CCU oxidase (Subunit III) HV352_RS17935 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV352_RS17960 ENOG4107RDB Major Facilitator HV352_RS17965 ENOG4108VPT UPF0234 protein HV352_RS17970 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV352_RS17975 ENOG4107S0N DJ-1 family HV352_RS17995 ENOG4105CTB Polyprenyl synthetase HV352_RS18005 ENOG4105CPC Aldo Keto reductase HV352_RS18010 ENOG4108ZAI phosphatidylglycerophosphatase a HV352_RS18015 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV352_RS18020 ENOG4107YIM Involved in the transcription termination process (By similarity) HV352_RS18025 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV352_RS18030 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV352_RS18040 ENOG4108KIC (LipO)protein HV352_RS18045 ENOG4105DRB nucleoside-specific channel-forming protein HV352_RS18060 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV352_RS18065 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV352_RS18070 ENOG4105VIE preprotein translocase, subunit YajC HV352_RS18075 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HV352_RS18080 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HV352_RS18090 ENOG4105D3R alkyl hydroperoxide reductase HV352_RS18105 ENOG4105EFZ amidohydrolase HV352_RS18115 ENOG4105CHJ isochorismatase hydrolase HV352_RS18120 ENOG4105EQ1 Transcriptional regulator HV352_RS18125 ENOG4107R28 alpha amylase, catalytic region HV352_RS18130 ENOG4105C85 amino acid HV352_RS18135 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV352_RS18140 ENOG4105BZU Histidine kinase HV352_RS18150 ENOG4107RH8 nuclease SbcCD subunit D HV352_RS18155 ENOG4105EYH Exonuclease HV352_RS18165 ENOG4105DKQ ROK family HV352_RS18175 ENOG4105NBK UPF0345 protein HV352_RS18180 ENOG4105HBA AroM protein HV352_RS18185 ENOG4105SS3 HV352_RS18195 ENOG4108UPT UPF0178 protein HV352_RS18200 ENOG4105II7 pyrroline-5-carboxylate reductase HV352_RS18205 ENOG4105BZU Histidine kinase HV352_RS18210 ENOG4105VIF phosphate starvation-inducible protein HV352_RS18215 ENOG4105G6Z alkaline phosphatase HV352_RS18230 ENOG4105CPF Cell wall formation (By similarity) HV352_RS18235 ENOG4105UNH Membrane HV352_RS18240 ENOG4105FR5 inner membrane protein YaiY HV352_RS18245 ENOG4107QS8 (LipO)protein HV352_RS18250 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV352_RS18255 ENOG4107R6D beta-lactam binding protein AmpH HV352_RS18260 ENOG4108PNB DNA-binding transcriptional regulator HV352_RS18265 ENOG4108NSE outer membrane autotransporter barrel HV352_RS18270 ENOG4105D52 delta-aminolevulinic acid dehydratase HV352_RS18275 ENOG4105E2B Taurine dioxygenase HV352_RS18280 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV352_RS18285 ENOG4108ETV ABC transporter HV352_RS18290 ENOG4106FTQ Taurine ABC transporter, periplasmic HV352_RS18295 ENOG4108KX4 response regulator HV352_RS18300 ENOG4105BZU Histidine kinase HV352_RS18305 ENOG4105CXY transporter HV352_RS18310 ENOG4105C4Y ABC transporter HV352_RS18315 ENOG4107RCV ABC transporter, permease HV352_RS18320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV352_RS18325 ENOG4107QK5 Homocysteine s-methyltransferase HV352_RS18330 ENOG4108IQI permease HV352_RS18335 ENOG4108SC4 )-transporter HV352_RS18370 ENOG4108K2P TRANSCRIPTIONal HV352_RS18385 ENOG4105N0E Protein of unknown function (DUF2543) HV352_RS18420 ENOG4105CKT filamentous hemagglutinin HV352_RS18425 ENOG4105D5K Hemolysin activator protein HV352_RS18435 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS18440 ENOG4105CNT hydrolase family 2 HV352_RS18455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV352_RS18460 ENOG4105DXD 2-methylcitrate dehydratase HV352_RS18465 ENOG4105BZN citrate synthase HV352_RS18470 ENOG4105CR4 methylisocitrate lyase HV352_RS18475 ENOG4108JU7 Transcriptional regulator HV352_RS18480 ENOG4105TDT uncharacterized protein yahO HV352_RS18485 ENOG4105E82 cytochrome subunit of dehydrogenase HV352_RS18490 ENOG4105BZU Histidine kinase HV352_RS18495 ENOG4105HEE Binding Domain protein HV352_RS18515 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS18530 ENOG4105CEE C4-dicarboxylate transporter HV352_RS18535 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV352_RS18545 ENOG4105DTA methyltransferase HV352_RS18550 ENOG4107R7Y intracellular protease Pfpi family HV352_RS18555 ENOG4105CUB amino acid HV352_RS18560 ENOG4105CFQ glutamine synthetase HV352_RS18565 ENOG4108Z86 Glutamine amidotransferase HV352_RS18570 ENOG4107VRI Transcriptional regulator HV352_RS18575 ENOG4105C26 Dehydrogenase HV352_RS18580 ENOG4105CJP fad dependent oxidoreductase HV352_RS18595 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HV352_RS18600 ENOG4108USZ hydrogenase HV352_RS18605 ENOG4108VXY Hydrogenase-1 operon protein HyaE HV352_RS18610 ENOG4105MVP hydrogenase-1 operon protein HyaF HV352_RS18615 ENOG4105C4M (Ubiquinol oxidase) subunit I HV352_RS18620 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV352_RS18695 ENOG4105DFP Integrase HV352_RS18710 ENOG4108M8H domain protein HV352_RS18730 ENOG4106PYX Receptor HV352_RS18750 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV352_RS18755 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HV352_RS18760 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HV352_RS18770 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HV352_RS18775 ENOG4105V1F Fermentation respiration switch protein HV352_RS18785 ENOG4105CIN aminoacyl-histidine dipeptidase HV352_RS18790 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV352_RS18810 ENOG4108YS0 lipoprotein YafL HV352_RS18815 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV352_RS18820 ENOG4105E7A Glutamine amidotransferase HV352_RS18830 ENOG4107QPN acyl-Coa dehydrogenase HV352_RS18835 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV352_RS18845 ENOG4105CMB EAL domain-containing protein HV352_RS18860 ENOG4108MDY Fimbrial HV352_RS18870 ENOG4108FZ9 Chaperone HV352_RS18875 ENOG4106PG1 outer membrane usher protein HV352_RS18885 ENOG4108TH4 Major fimbrial subunit HV352_RS18905 ENOG4107RZZ dna polymerase iii epsilon subunit HV352_RS18910 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV352_RS18915 ENOG4105D1A Methyltransferase HV352_RS18920 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HV352_RS18925 ENOG4105E9H Lytic Murein transglycosylase HV352_RS18930 ENOG4105F2W methyltransferase HV352_RS18940 ENOG4105F27 Major Facilitator HV352_RS18945 ENOG4105HEI LysR family (Transcriptional regulator HV352_RS18950 ENOG4105CV8 reductase HV352_RS18980 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV352_RS18985 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV352_RS18990 ENOG4108UMI ABC transporter, permease HV352_RS18995 ENOG4105D01 (LipO)protein HV352_RS19000 ENOG4108R8X outer membrane lipoprotein HV352_RS19005 ENOG4108R96 Methyltransferase, YaeB family HV352_RS19010 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HV352_RS19015 ENOG4108UY0 (LipO)protein HV352_RS19020 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV352_RS19025 ENOG4108YZN class I peptide chain release factor HV352_RS19030 ENOG4108VWS Yaeq family HV352_RS19040 ENOG4105M1T rho-binding antiterminator HV352_RS19045 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV352_RS19050 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV352_RS19055 ENOG4105CXN decarboxylase HV352_RS19060 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HV352_RS19065 ENOG4105C0B DNA polymerase III (alpha subunit) HV352_RS19070 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV352_RS19075 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV352_RS19090 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV352_RS19095 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV352_RS19100 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV352_RS19110 ENOG4105KNE Phosphatidate cytidylyltransferase HV352_RS19120 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV352_RS19125 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HV352_RS19130 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HV352_RS19140 ENOG4105CE9 30S ribosomal protein S2 HV352_RS19145 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV352_RS19150 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HV352_RS19155 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HV352_RS19165 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV352_RS19170 ENOG4105C0H protease HV352_RS19175 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HV352_RS19180 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HV352_RS19185 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV352_RS19190 ENOG4105EN6 Membrane HV352_RS19195 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HV352_RS19200 ENOG4105CMQ Chloride channel HV352_RS19210 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV352_RS19215 ENOG4105J76 Periplasmic binding protein HV352_RS19220 ENOG4105E0A ABC, transporter HV352_RS19225 ENOG4105E0K tonB-dependent siderophore receptor HV352_RS19230 ENOG4105BZ4 penicillin-binding protein HV352_RS19235 ENOG4105CQ7 ATP-dependent helicase HV352_RS19240 ENOG4107XID 2'-5' rna ligase HV352_RS19245 ENOG4105PW4 Sugar fermentation stimulation protein homolog HV352_RS19250 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HV352_RS19255 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HV352_RS19260 ENOG4105DJ0 Poly(A) Polymerase HV352_RS19265 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV352_RS19285 ENOG4107BJW polysaccharide deacetylase HV352_RS19290 ENOG4108YTN IIa component HV352_RS19295 ENOG4105E3A (ABC) transporter HV352_RS19300 ENOG4105DA5 (ABC) transporter HV352_RS19305 ENOG41077A9 carbonic anhydrase HV352_RS19310 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV352_RS19315 ENOG4105DZG Dehydrogenase HV352_RS19325 ENOG4105E3B Multicopper oxidase HV352_RS19330 ENOG4108ZRK uncharacterized protein yacC HV352_RS19335 ENOG4105FKQ transcriptional regulator HV352_RS19340 ENOG4107QNK )-transporter HV352_RS19355 ENOG4107QIJ Aconitate hydratase 2 HV352_RS19360 ENOG4108NST exported protein HV352_RS19375 ENOG4107QN2 dihydrolipoyl dehydrogenase HV352_RS19380 ENOG4107QSN dihydrolipoamide acetyltransferase HV352_RS19385 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV352_RS19395 ENOG4105C85 amino acid HV352_RS19400 ENOG4105CT4 transporter HV352_RS19405 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HV352_RS19410 ENOG4106A72 regulatory protein AmpE HV352_RS19420 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV352_RS19425 ENOG4108ZUW Major pilin subunit HV352_RS19430 ENOG4107QHF type ii secretion system protein e HV352_RS19435 ENOG4105D7Q type ii secretion system HV352_RS19440 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV352_RS19445 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV352_RS19450 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HV352_RS19455 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HV352_RS19460 ENOG4105M6F mutator MutT protein HV352_RS19470 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HV352_RS19480 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV352_RS19485 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV352_RS19490 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV352_RS19495 ENOG4105CPF Cell wall formation (By similarity) HV352_RS19505 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HV352_RS19510 ENOG4105CNI cell division protein FtsW HV352_RS19515 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HV352_RS19520 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HV352_RS19525 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV352_RS19530 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV352_RS19535 ENOG4105CJN penicillin-binding protein HV352_RS19540 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV352_RS19550 ENOG4108V6E Cell division protein mraZ HV352_RS19555 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV352_RS19560 ENOG4108ZP8 Acetolactate synthase small subunit HV352_RS19565 ENOG4105C7K acetolactate synthase HV352_RS19570 ENOG41064T2 transcriptional regulator, lysR family HV352_RS19590 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV352_RS19595 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV352_RS19600 ENOG4105S8Q sugar efflux transporter HV352_RS19620 ENOG4106SMU thiamine transporter membrane protein HV352_RS19630 ENOG4108KF1 Membrane HV352_RS19650 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV352_RS19660 ENOG4105CQ2 DNA polymerase HV352_RS19665 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HV352_RS19670 ENOG4105D3G Pseudouridine synthase HV352_RS19680 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HV352_RS19690 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HV352_RS19695 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HV352_RS19700 ENOG4105NWN ApaG protein HV352_RS19705 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HV352_RS19715 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV352_RS19725 ENOG4105M5B (LipO)protein HV352_RS19730 ENOG4105C54 Major Facilitator superfamily HV352_RS19735 ENOG4105WQV ferredoxin-like protein HV352_RS19740 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV352_RS19785 ENOG4108XNW Transcriptional activatory protein CaiF HV352_RS19790 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV352_RS19795 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV352_RS19800 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HV352_RS19805 ENOG4107P2S Transcriptional regulator HV352_RS19820 ENOG4105DAS pts system HV352_RS19825 ENOG4105ETZ PTS System HV352_RS19830 ENOG4105F3R pts system mannose fructose sorbose family iid HV352_RS19840 ENOG4108Y83 glucose-6-phosphate isomerase HV352_RS19845 ENOG4105DU0 nucleoside hydrolase HV352_RS19850 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HV352_RS19855 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV352_RS19865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HV352_RS19870 ENOG4105DTN riboflavin biosynthesis protein ribF HV352_RS19895 ENOG41063Z6 transcriptional regulator, lysR family HV352_RS19910 ENOG4105CFG Acts as a chaperone (By similarity) HV352_RS19915 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV352_RS19925 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV352_RS19930 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV352_RS19935 ENOG4105BZG amino acid carrier protein HV352_RS19940 ENOG4105D1Q UPF0246 protein HV352_RS19945 ENOG4105D98 threonine synthase HV352_RS19955 ENOG4105CFH Aspartokinase HV352_RS19965 ENOG4106FVC RNA methyltransferase HV352_RS19970 ENOG410759A HV352_RS19975 ENOG41065U4 response regulator HV352_RS19980 ENOG4105CT7 inner membrane cred family protein HV352_RS19985 ENOG4105EB3 Histidine kinase HV352_RS19990 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV352_RS19995 ENOG4108RH0 Crea protein HV352_RS20000 ENOG4105UEI Transcriptional Regulator AraC Family HV352_RS20005 ENOG4105CVJ phosphoglycerate mutase HV352_RS20010 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV352_RS20015 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HV352_RS20020 ENOG4107SC1 transglycosylase HV352_RS20025 ENOG4105C5H ABC transporter HV352_RS20030 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV352_RS20035 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV352_RS20040 ENOG4105EAC phosphoserine phosphatase HV352_RS20045 ENOG41062Z9 Membrane HV352_RS20075 ENOG4105G0K glycine radical enzyme YjjI family HV352_RS20080 ENOG41076CZ activating enzyme HV352_RS20085 ENOG4105EYA deoxyribonuclease HV352_RS20090 ENOG4108NRW Phospholipase, patatin family HV352_RS20100 ENOG4105K3G Periplasmic Protein HV352_RS20105 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HV352_RS20110 ENOG4105PAD Hydrolase HV352_RS20115 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV352_RS20120 ENOG4108WPU DNA polymerase III subunit psi HV352_RS20125 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV352_RS20145 ENOG4105YBH Protein of unknown function (DUF1435) HV352_RS20150 ENOG4105BZU Histidine kinase HV352_RS20155 ENOG4108819 ferric iron reductase HV352_RS20160 ENOG4105CK1 PTS System HV352_RS20165 ENOG4108UIN ybak prolyl-trna synthetase associated region HV352_RS20170 ENOG4108T94 DNA-binding transcriptional activator BglJ HV352_RS20175 ENOG4108N8T regulatoR HV352_RS20180 ENOG4105DWK Membrane HV352_RS20185 ENOG4107XM3 UPF0442 protein HV352_RS20190 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HV352_RS20195 ENOG4106CVF DNA replication protein HV352_RS20200 ENOG4105RI1 glycoprotein receptor HV352_RS20215 ENOG4105CPQ Dehydrogenase HV352_RS20220 ENOG410617M Transcriptional regulator HV352_RS20225 ENOG4108I5G Major Facilitator superfamily HV352_RS20230 ENOG4105XYF acetyltransferase HV352_RS20235 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS20245 ENOG4105D22 carbon starvation protein HV352_RS20250 ENOG4105VCD cytoplasmic protein HV352_RS20255 ENOG4105CKI cobalamin synthesis protein HV352_RS20300 ENOG4106DIZ Domain of unknown function (DUF1127) HV352_RS20305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV352_RS20310 ENOG4105DNE Transposase HV352_RS20315 ENOG4106AXJ AraC family transcriptional regulator HV352_RS20325 ENOG41083G8 Multidrug resistance protein MdtM HV352_RS20330 ENOG4105C28 cystathionine HV352_RS20335 ENOG4105CK2 sodium dicarboxylate symporter HV352_RS20340 ENOG410642W LysR family Transcriptional regulator HV352_RS20345 ENOG4106BRA Membrane HV352_RS20350 ENOG4105CBP Major Facilitator HV352_RS20360 ENOG4105FCK Membrane HV352_RS20370 ENOG4105C6F GntR Family Transcriptional Regulator HV352_RS20375 ENOG4105DEI Mannitol dehydrogenase HV352_RS20385 ENOG4107EFN gluconate transport system permease 3 HV352_RS20390 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HV352_RS20395 ENOG4107QR9 Iron-sulfur cluster binding protein HV352_RS20400 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV352_RS20455 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV352_RS20460 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV352_RS20465 ENOG4105ZS6 Protein of unknown function (DUF987) HV352_RS20470 ENOG4108XS9 dna repair protein HV352_RS20475 ENOG4106H6R UPF0380 protein HV352_RS20535 ENOG4105K7W phage-related replication protein HV352_RS20540 ENOG4105C0D helicase HV352_RS20545 ENOG4107QMH DNA methylase HV352_RS20570 ENOG4105DQ4 alcohol dehydrogenase HV352_RS20575 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV352_RS20580 ENOG4105CPQ Dehydrogenase HV352_RS20585 ENOG4105CHR reductase HV352_RS20590 ENOG4105C6Z Gluconate HV352_RS20595 ENOG4105K2J Transcriptional regulator HV352_RS20600 ENOG4105D7A ATP-binding protein HV352_RS20605 ENOG4108K5H permease YjgP YjgQ family protein HV352_RS20610 ENOG4108M8S permease YjgP YjgQ family protein HV352_RS20615 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV352_RS20620 ENOG4105MYG DNA polymerase iii, chi subunit HV352_RS20625 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV352_RS20630 ENOG4108MJ3 acetyltransferase HV352_RS20640 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HV352_RS20645 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV352_RS20655 ENOG4105XEP YhcH YjgK YiaL family protein HV352_RS20660 ENOG4105CEU Arginine dihydrolase HV352_RS20670 ENOG4105DBV ornithine carbamoyltransferase HV352_RS20675 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV352_RS20680 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV352_RS20690 ENOG4107C93 pyrBI operon leader peptide HV352_RS20700 ENOG4105CXT aspartate transcarbamylase HV352_RS20705 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HV352_RS20710 ENOG4105KME endoribonuclease L-psp HV352_RS20715 ENOG4107EF2 surface-exposed virulence protein HV352_RS20725 ENOG4105D4X repressor HV352_RS20730 ENOG4105C5Y PTS System HV352_RS20735 ENOG4105CG3 alpha amylase, catalytic region HV352_RS20740 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV352_RS20745 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV352_RS20755 ENOG4105CS6 Rhs element vgr protein HV352_RS20760 ENOG4105K4U addiction module toxin, RelE StbE family HV352_RS20775 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV352_RS20840 ENOG4105EMD TRANSCRIPTIONal HV352_RS20855 ENOG41069H0 dihydroorotase EC 3.5.2.3 HV352_RS20885 ENOG4108XVM Cytochrome b(562) HV352_RS20890 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV352_RS20895 ENOG4105N42 UPF0307 protein HV352_RS20900 ENOG4105CK1 PTS System HV352_RS20905 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HV352_RS20910 ENOG4105F8D glycoside hydrolase family 4 HV352_RS20915 ENOG4105C2X Arabinose 5-phosphate isomerase HV352_RS20920 ENOG4105DFU Cell wall formation (By similarity) HV352_RS20925 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HV352_RS20930 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS20935 ENOG41062B0 ABC transporter, permease HV352_RS20940 ENOG4107R9N ABC transporter HV352_RS20945 ENOG4105C2J ABC transporter HV352_RS20950 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV352_RS20955 ENOG4105F0N pyrophosphate phospho-hydrolase HV352_RS20960 ENOG4108NS2 receptor HV352_RS20965 ENOG4105D05 Receptor HV352_RS20970 ENOG4108ZHD aig2 family HV352_RS20975 ENOG4105MA0 exported protein HV352_RS20980 ENOG4105CFU surface antigen HV352_RS20990 ENOG4105C37 (CBS) domain HV352_RS20995 ENOG41061GZ Protein of unknown function (DUF1107) HV352_RS21000 ENOG4108UUE Transcriptional regulator HV352_RS21005 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV352_RS21010 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HV352_RS21015 ENOG4105KVH Transcriptional regulator HV352_RS21020 ENOG4105ECR NmrA family HV352_RS21030 ENOG4105DXC membrane HV352_RS21035 ENOG4105C8Q Methyl-accepting chemotaxis HV352_RS21040 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HV352_RS21045 ENOG4105C85 amino acid HV352_RS21050 ENOG4108V1T peptidylprolyl cis-trans isomerase HV352_RS21055 ENOG4105FHY Opacity-associated protein A HV352_RS21065 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HV352_RS21070 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV352_RS21075 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HV352_RS21085 ENOG4105EJ9 Membrane HV352_RS21090 ENOG4105KIT UPF0379 protein yjfY HV352_RS21105 ENOG4105H6Q decarboxylase HV352_RS21130 ENOG4105DW5 Transcriptional regulator HV352_RS21135 ENOG4108MXZ Esterase HV352_RS21140 ENOG4105WSB biofilm stress and motility protein A HV352_RS21145 ENOG4105S17 UPF0379 protein yjfN HV352_RS21150 ENOG4105CSU acyl-Coa dehydrogenase HV352_RS21155 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV352_RS21160 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV352_RS21170 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HV352_RS21180 ENOG4105EPW hflc protein HV352_RS21185 ENOG4107QJR hflk protein HV352_RS21190 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV352_RS21195 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HV352_RS21205 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HV352_RS21210 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV352_RS21215 ENOG4105K8N protein family UPF0079, ATPase HV352_RS21220 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV352_RS21225 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV352_RS21255 ENOG4105DJ4 phosphatidylserine decarboxylase HV352_RS21260 ENOG4105EGS Mechanosensitive ion channel HV352_RS21265 ENOG4106CG8 Inner membrane protein YjeO HV352_RS21275 ENOG4107SC7 Inner membrane transporter yjeM HV352_RS21280 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HV352_RS21285 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV352_RS21290 ENOG4105E33 succinate dehydrogenase HV352_RS21300 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HV352_RS21345 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV352_RS21350 ENOG4105MTB Uncharacterized protein YjeJ HV352_RS21355 ENOG4108ZVF (LipO)protein HV352_RS21360 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HV352_RS21370 ENOG4105DVH amino acid HV352_RS21375 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV352_RS21380 ENOG4108IJ0 Aspartate ammonia-lyase HV352_RS21385 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV352_RS21395 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV352_RS21400 ENOG4108SIC Transcriptional regulator HV352_RS21430 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV352_RS21435 ENOG4108MRH transcriptional regulatory protein HV352_RS21445 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV352_RS21450 ENOG4107GFK fumarate HV352_RS21455 ENOG4108R5S membrane HV352_RS21460 ENOG4105W3H MtN3 and saliva related transmembrane protein HV352_RS21465 ENOG4105CT4 transporter HV352_RS21470 ENOG4105F8D glycoside hydrolase family 4 HV352_RS21475 ENOG4108K2B transcriptional regulator HV352_RS21480 ENOG4105CXN decarboxylase HV352_RS21485 ENOG4106ZGR Transcriptional regulator HV352_RS21490 ENOG4105D5Q Arginine ornithine antiporter HV352_RS21495 ENOG4105DIJ Phosphoethanolamine transferase HV352_RS21500 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV352_RS21505 ENOG4105ECM Sensor protein basS pmrB HV352_RS21515 ENOG4105CSH Transporter HV352_RS21520 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HV352_RS21525 ENOG4108YIV HV352_RS21530 ENOG4108F5E vimentin HV352_RS21535 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV352_RS21540 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV352_RS21545 ENOG4105D5T phosphonate abc transporter HV352_RS21550 ENOG4105EHI Phosphonate ABC transporter, periplasmic HV352_RS21560 ENOG4107RJJ Transcriptional regulator HV352_RS21565 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HV352_RS21570 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HV352_RS21575 ENOG4105EKV Phosphonate metabolism protein HV352_RS21580 ENOG4105FT8 Phosphonate metabolism HV352_RS21585 ENOG4105ENV phosphonate C-P lyase system protein PhnK HV352_RS21590 ENOG4105HRV phosphonate c-p lyase system protein phnl HV352_RS21595 ENOG4105FD8 phosphonate metabolism protein PhnM HV352_RS21600 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HV352_RS21605 ENOG410849A acetyltransferase, (GNAT) family HV352_RS21610 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HV352_RS21625 ENOG4105C2J ABC transporter HV352_RS21630 ENOG4105CNN ABC, transporter HV352_RS21635 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV352_RS21675 ENOG4105D2N Aldolase HV352_RS21695 ENOG41082ND Uncharacterized protein yjcO HV352_RS21700 ENOG4105CK2 sodium dicarboxylate symporter HV352_RS21705 ENOG4108W0S formate-dependent nitrite reductase complex HV352_RS21715 ENOG4108QKW cytochrome c-type biogenesis protein HV352_RS21720 ENOG4105DVI reductase, NrfD HV352_RS21725 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV352_RS21730 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HV352_RS21740 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV352_RS21745 ENOG41062QD Membrane HV352_RS21750 ENOG4107QN1 sodium solute HV352_RS21755 ENOG41067MG lrgb family HV352_RS21765 ENOG4105CMU LysR family (Transcriptional regulator HV352_RS21770 ENOG4105EEQ Na H antiporter HV352_RS21775 ENOG4105C7N Xanthine uracil vitamin C permease HV352_RS21780 ENOG4108Z4X TRANSCRIPTIONal HV352_RS21785 ENOG4108W3Q Transcriptional regulator HV352_RS21790 ENOG4108M8H domain protein HV352_RS21795 ENOG4105PMV Membrane HV352_RS21800 ENOG4108UUM single-stranded DNA-binding protein HV352_RS21805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV352_RS21810 ENOG4105MSB protein, conserved in bacteria HV352_RS21815 ENOG4105F0S class B acid phosphatase HV352_RS21820 ENOG4105CGF Aromatic amino acid aminotransferase HV352_RS21830 ENOG4105CDU Replicative dna helicase HV352_RS21835 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV352_RS21840 ENOG4105P4Z Phage shock protein G HV352_RS21845 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV352_RS21855 ENOG4105MYN Zinc uptake regulation protein HV352_RS21860 ENOG4105VDW Csbd family HV352_RS21865 ENOG4107R73 Mate efflux family protein HV352_RS21875 ENOG41080IJ Diacylglycerol kinase HV352_RS21880 ENOG4105E55 glycerol-3-phosphate acyltransferase HV352_RS21885 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HV352_RS21890 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HV352_RS21895 ENOG4107W52 maltose operon periplasmic protein HV352_RS21905 ENOG4108IJ9 (ABC) transporter HV352_RS21910 ENOG4107FKK extracellular solute-binding protein family 1 HV352_RS21915 ENOG4105D56 permease protein HV352_RS21920 ENOG4105EG2 ABC transporter, permease HV352_RS21925 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HV352_RS21930 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV352_RS21935 ENOG4105E3R (LipO)protein HV352_RS21940 ENOG4108Q9C Periplasmic Protein HV352_RS21945 ENOG4108MDC (LipO)protein HV352_RS21960 ENOG4105CFH Aspartokinase HV352_RS21965 ENOG4105C09 Bile acid HV352_RS21970 ENOG4108ZR5 Conserved Protein HV352_RS21975 ENOG4105FE9 pseudouridine synthase HV352_RS21980 ENOG4105ECQ AraC Family Transcriptional Regulator HV352_RS21995 ENOG4105EAM Na Pi-cotransporter HV352_RS22000 ENOG4105C3R Methionine synthase HV352_RS22005 ENOG41069M3 Transcriptional regulator HV352_RS22010 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HV352_RS22015 ENOG4108I9X Isocitrate lyase HV352_RS22020 ENOG4107QP3 malate synthase g HV352_RS22025 ENOG4105CVG Homoserine O-transsuccinylase HV352_RS22050 ENOG4105C12 Phosphoribosylglycinamide synthetase HV352_RS22055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV352_RS22060 ENOG4105BZU Histidine kinase HV352_RS22070 ENOG4108T8B Protein of unknown function (DUF1481) HV352_RS22075 ENOG4105K70 DNA-binding protein HV352_RS22080 ENOG4105R2J Conserved Protein HV352_RS22090 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HV352_RS22100 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HV352_RS22115 ENOG4105D06 uba thif-type nad fad binding protein HV352_RS22120 ENOG4105WHD thiamine biosynthesis protein ThiS HV352_RS22130 ENOG4105D41 biosynthesis protein thiH HV352_RS22135 ENOG4105VEQ Cold shock protein HV352_RS22145 ENOG4105VCP PTS System HV352_RS22150 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV352_RS22155 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV352_RS22160 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HV352_RS22165 ENOG4108VZM 50s ribosomal protein L10 HV352_RS22170 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HV352_RS22175 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HV352_RS22180 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV352_RS22185 ENOG4105PM1 preprotein translocase subunit SecE HV352_RS22220 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV352_RS22225 ENOG4105D4A Cell wall formation (By similarity) HV352_RS22270 ENOG4108Y73 Membrane HV352_RS22275 ENOG4105EJ2 Transcriptional regulator HV352_RS22285 ENOG4105C5Q Transcriptional regulator HV352_RS22290 ENOG4108NNZ chitinase HV352_RS22295 ENOG4105CH7 arginosuccinase HV352_RS22300 ENOG4105CAS nag kinase HV352_RS22310 ENOG4105CWC Acetylornithine deacetylase HV352_RS22315 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HV352_RS22320 ENOG4105DIJ Phosphoethanolamine transferase HV352_RS22325 ENOG4106R3P AraC family transcriptional regulator HV352_RS22330 ENOG4108XCZ PTS System HV352_RS22335 ENOG4108AHH pyruvate formate lyase II activase HV352_RS22345 ENOG4108YRF PTS System HV352_RS22350 ENOG4105DM4 PTS System HV352_RS22355 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV352_RS22365 ENOG4105DCT glycerol dehydrogenase HV352_RS22370 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HV352_RS22375 ENOG4105SYT Methylenetetrahydrofolate reductase HV352_RS22380 ENOG4105CN8 Transcriptional regulator HV352_RS22390 ENOG4105CGH 5'-nucleotidase HV352_RS22400 ENOG4105CFH Aspartokinase HV352_RS22405 ENOG4105C28 cystathionine HV352_RS22410 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HV352_RS22415 ENOG4105CT4 transporter HV352_RS22420 ENOG4108QGT oligogalacturonate-specific porin HV352_RS22430 ENOG4105C25 Primosomal protein n' HV352_RS22435 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS22440 ENOG41063M6 Cell Division Protein HV352_RS22450 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HV352_RS22455 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV352_RS22465 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HV352_RS22470 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV352_RS22475 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV352_RS22480 ENOG4105CBT Fructose-1,6-bisphosphatase HV352_RS22485 ENOG4105DP0 ferredoxin-NADP reductase HV352_RS22490 ENOG4108VTS Membrane HV352_RS22495 ENOG4105EBK exported protein HV352_RS22510 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HV352_RS22515 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV352_RS22520 ENOG4105CTQ phosphohexokinase HV352_RS22525 ENOG41076HS cation diffusion facilitator family transporter HV352_RS22530 ENOG4105FMW periplasmic HV352_RS22535 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV352_RS22540 ENOG4105E0F Histidine kinase HV352_RS22545 ENOG4105R9B Major Facilitator HV352_RS22550 ENOG4108KHF Resistance protein HV352_RS22555 ENOG4108K85 Transcriptional regulator HV352_RS22560 ENOG4108RPX mosc domain containing protein HV352_RS22565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV352_RS22575 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV352_RS22585 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HV352_RS22590 ENOG4105EDR glucose galactose transporter HV352_RS22595 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV352_RS22600 ENOG4105C8I hydrolase, family 38 HV352_RS22605 ENOG4105DM4 PTS System HV352_RS22610 ENOG4108YRF PTS System HV352_RS22620 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV352_RS22625 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV352_RS22635 ENOG4105DKG l-rhamnose isomerase HV352_RS22645 ENOG4105C0A alcohol dehydrogenase HV352_RS22665 ENOG4108UMN azlc family HV352_RS22675 ENOG41064BA PTS system, fructose-specific, IIA component HV352_RS22680 ENOG4105DM4 PTS System HV352_RS22685 ENOG4105CN9 Peptidase m42 family protein HV352_RS22690 ENOG4106C3V frv operon regulatory protein HV352_RS22710 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV352_RS22715 ENOG4108MG3 formate dehydrogenase HV352_RS22720 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HV352_RS22730 ENOG41068KX affects formate dehydrogenase-N HV352_RS22740 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HV352_RS22745 ENOG4108Z3N Transcriptional regulator HV352_RS22750 ENOG4105SUU thioesterase domain HV352_RS22760 ENOG4107S2Z UPF0761 membrane protein HV352_RS22765 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HV352_RS22770 ENOG4105E98 transcriptional regulator DeoR family HV352_RS22775 ENOG4108MGF sugar kinase HV352_RS22780 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV352_RS22785 ENOG4105D2M Aldolase HV352_RS22790 ENOG4107QKS N-acylglucosamine 2-epimerase HV352_RS22795 ENOG4107WI4 Aldose-1-epimerase HV352_RS22800 ENOG4105CJQ hydrolase, family 31 HV352_RS22805 ENOG4105CT4 transporter HV352_RS22810 ENOG4105CT4 transporter HV352_RS22815 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HV352_RS22820 ENOG4105CI3 gtp-binding protein typa HV352_RS22825 ENOG4105C5F glutamine synthetase HV352_RS22830 ENOG4105CUX Signal transduction histidine kinase HV352_RS22835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV352_RS22840 ENOG4106FIY HV352_RS22845 ENOG4105D4P Coproporphyrinogen iii oxidase HV352_RS22865 ENOG4105C2M dna polymerase I HV352_RS22870 ENOG4106HNH Acyl-transferase HV352_RS22875 ENOG4108Z33 Thiol disulfide Interchange Protein HV352_RS22885 ENOG4105PC1 Conserved Protein HV352_RS22890 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV352_RS22895 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV352_RS22925 ENOG4108RR8 protoporphyrinogen oxidase HV352_RS22930 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV352_RS22935 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV352_RS22945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV352_RS22955 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS22960 ENOG4105DKQ ROK family HV352_RS22965 ENOG4107QK7 reductase HV352_RS22970 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV352_RS22975 ENOG4105MDZ Transcriptional activator rfaH HV352_RS22980 ENOG4105F8V Hydrolase, tatD family HV352_RS22985 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV352_RS22990 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV352_RS22995 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV352_RS23005 ENOG4105JC1 sterol-binding domain protein HV352_RS23015 ENOG4105CGY Dna recombination protein HV352_RS23020 ENOG4107SXA Phosphorylase HV352_RS23025 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV352_RS23030 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HV352_RS23035 ENOG4105DZ2 Transcriptional regulator HV352_RS23040 ENOG4105EMK carboxylate amino acid amine transporter HV352_RS23045 ENOG4105DQF Hydrolase HV352_RS23050 ENOG4108EUD Lysophospholipase HV352_RS23055 ENOG410829K Lysine exporter protein (Lyse ygga) HV352_RS23060 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV352_RS23065 ENOG4105C9U ATP-dependent DNA helicase RecQ HV352_RS23070 ENOG4105HDD phospholipase HV352_RS23075 ENOG4108VUY thioesterase Superfamily protein HV352_RS23080 ENOG4105FR1 rard protein HV352_RS23085 ENOG4107QUT magnesium and cobalt transport protein CorA HV352_RS23090 ENOG4105C4R Atp-dependent dna helicase HV352_RS23095 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV352_RS23100 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV352_RS23105 ENOG4105CT0 Protein of unknown function, DUF484 HV352_RS23115 ENOG4105S7Z (LipO)protein HV352_RS23125 ENOG4107T0K Adenylate cyclase HV352_RS23135 ENOG41076E6 Uroporphyrinogen-III Synthase HV352_RS23140 ENOG4105ECF c-methyltransferase HV352_RS23145 ENOG410601J HemY protein HV352_RS23170 ENOG4105C85 amino acid HV352_RS23175 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HV352_RS23180 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HV352_RS23185 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HV352_RS23190 ENOG4105EGZ biosynthesis protein HV352_RS23195 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV352_RS23200 ENOG4108WJ1 acetyltransferase HV352_RS23205 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HV352_RS23210 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV352_RS23215 ENOG4108IJ1 Dehydrogenase HV352_RS23220 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV352_RS23225 ENOG4105SFE lipopolysaccharide biosynthesis protein HV352_RS23230 ENOG4105ESV Glycosyl transferase, family 4 HV352_RS23235 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV352_RS23255 ENOG4105C9X ppx gppa phosphatase HV352_RS23260 ENOG4105C4R Atp-dependent dna helicase HV352_RS23265 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV352_RS23275 ENOG4105EMY transcriptional regulator HV352_RS23280 ENOG4105RKW reductase (By HV352_RS23285 ENOG4105C7B Threonine dehydratase HV352_RS23295 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV352_RS23300 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV352_RS23315 ENOG4105C0P Mg chelatase subunit ChlI HV352_RS23320 ENOG4108WFC UPF0438 protein yifE HV352_RS23360 ENOG4107EJG GntR family transcriptional regulator HV352_RS23365 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV352_RS23370 ENOG4105ETE Transcriptional regulator (LacI family HV352_RS23375 ENOG4108RVA ribokinase HV352_RS23380 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV352_RS23385 ENOG4105CNN ABC, transporter HV352_RS23395 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HV352_RS23410 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HV352_RS23420 ENOG4108VVK transcriptional Regulator, AsnC HV352_RS23425 ENOG4105QTB Flavodoxin HV352_RS23435 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HV352_RS23440 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV352_RS23445 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HV352_RS23455 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV352_RS23460 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV352_RS23465 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HV352_RS23470 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HV352_RS23475 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HV352_RS23480 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HV352_RS23485 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV352_RS23490 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV352_RS23495 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV352_RS23500 ENOG4105C8U phosphate abc transporter HV352_RS23505 ENOG4105E2Z phosphate ABC transporter (Permease HV352_RS23510 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV352_RS23520 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV352_RS23525 ENOG4105C7N Xanthine uracil vitamin C permease HV352_RS23530 ENOG4108YYH Nadph-dependent fmn reductase HV352_RS23535 ENOG4105E8Q phosphopantetheinyl transferase HV352_RS23540 ENOG4105G2Y Transcriptional regulator HV352_RS23545 ENOG4105CNH Multidrug resistance protein MdtL HV352_RS23550 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HV352_RS23565 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HV352_RS23570 ENOG4105VG0 50S ribosomal protein l34