locus-tag	class	description
HV352_RS00010	COG0592	DNA-directed DNA polymerase activity
HV352_RS00025	COG0561	phosphatase activity
HV352_RS00035	COG0823	Involved in the tonB-independent uptake of proteins
HV352_RS00040	COG5645	(Lipo)protein
HV352_RS00070	COG2149	membrane
HV352_RS00080	COG0641	radical SAM
HV352_RS00090	COG2610	gluconate transmembrane transporter activity
HV352_RS00095	COG0583	DNA-binding transcription factor activity
HV352_RS00105	COG2814	Major facilitator Superfamily
HV352_RS00125	COG0028	Belongs to the TPP enzyme family
HV352_RS00130	COG0440	acetolactate synthase activity
HV352_RS00135	COG1349	DNA-binding transcription factor activity
HV352_RS00145	COG0738	Major facilitator superfamily
HV352_RS00155	COG2197	response regulator
HV352_RS00185	COG3620	sequence-specific DNA binding
HV352_RS00195	COG2723	6-phospho-beta-galactosidase activity
HV352_RS00210	COG1464	Belongs to the NlpA lipoprotein family
HV352_RS00215	COG0697	spore germination
HV352_RS00225	COG0604	alcohol dehydrogenase
HV352_RS00230	COG0583	DNA-binding transcription factor activity
HV352_RS00240	COG3539	Fimbrial protein
HV352_RS00260	COG2197	response regulator
HV352_RS00280	COG2771	luxR family
HV352_RS00310	COG2211	Major facilitator Superfamily
HV352_RS00315	COG1501	Belongs to the glycosyl hydrolase 31 family
HV352_RS00320	COG3711	transcriptional antiterminator
HV352_RS00325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS00325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS00325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS00330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS00335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS00335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS00345	COG0191	fructose-bisphosphate aldolase activity
HV352_RS00355	COG2982	Protein involved in outer membrane biogenesis
HV352_RS00360	COG2233	PERMEase
HV352_RS00365	COG0786	glutamate:sodium symporter activity
HV352_RS00370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV352_RS00375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV352_RS00380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV352_RS00390	COG0194	GDP metabolic process
HV352_RS00400	COG2860	membrane
HV352_RS00405	COG1561	YicC-like family, N-terminal region
HV352_RS00430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV352_RS00445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV352_RS00460	COG1519	Transferase
HV352_RS00465	COG0859	PFAM glycosyl transferase family 9
HV352_RS00470	COG0438	transferase activity, transferring glycosyl groups
HV352_RS00475	COG0515	serine threonine protein kinase
HV352_RS00500	COG0859	PFAM glycosyl transferase family 9
HV352_RS00505	COG0859	PFAM glycosyl transferase family 9
HV352_RS00525	COG0156	8-amino-7-oxononanoate synthase activity
HV352_RS00540	COG1216	Glycosyl transferase, family 2
HV352_RS00545	COG2861	carbohydrate metabolic process
HV352_RS00550	COG4942	peptidase
HV352_RS00560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV352_RS00565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV352_RS00585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV352_RS00590	COG2271	Major facilitator Superfamily
HV352_RS00600	COG2186	Transcriptional regulator
HV352_RS00620	COG3722	fumarate hydratase activity
HV352_RS00630	COG2213	PTS system mannitol-specific
HV352_RS00630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS00640	COG1566	PFAM secretion protein HlyD family protein
HV352_RS00645	COG0625	glutathione transferase activity
HV352_RS00655	COG3276	selenocysteine insertion sequence binding
HV352_RS00660	COG1454	alcohol dehydrogenase
HV352_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS00675	COG1566	PFAM secretion protein HlyD family protein
HV352_RS00680	COG0583	DNA-binding transcription factor activity
HV352_RS00685	COG3713	MltA-interacting MipA family protein
HV352_RS00690	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV352_RS00695	COG3977	Valine--pyruvate aminotransferase
HV352_RS00700	COG0366	Alpha amylase catalytic
HV352_RS00705	COG2992	FlgJ-related protein
HV352_RS00710	COG2207	Transcriptional regulator
HV352_RS00710	COG1609	Transcriptional regulator
HV352_RS00715	COG4214	carbohydrate transport
HV352_RS00725	COG4213	ABC transporter substrate-binding protein
HV352_RS00735	COG1070	Carbohydrate kinase
HV352_RS00740	COG4682	membrane
HV352_RS00745	COG4682	membrane
HV352_RS00750	COG3274	enterobacterial common antigen metabolic process
HV352_RS00775	COG1278	Cold shock
HV352_RS00780	COG2944	sequence-specific DNA binding
HV352_RS00795	COG2814	Major facilitator Superfamily
HV352_RS00800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS00810	COG1609	Transcriptional regulator
HV352_RS00815	COG2885	chlorophyll binding
HV352_RS00820	COG0243	molybdopterin cofactor binding
HV352_RS00825	COG0456	acetyltransferase
HV352_RS00830	COG2818	Glycosylase
HV352_RS00835	COG5571	outer membrane autotransporter
HV352_RS00840	COG2223	nitrite transmembrane transporter activity
HV352_RS00865	COG0747	negative chemotaxis
HV352_RS00870	COG0601	transmembrane transport
HV352_RS00875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV352_RS00880	COG0444	Belongs to the ABC transporter superfamily
HV352_RS00885	COG4608	Belongs to the ABC transporter superfamily
HV352_RS00890	COG2204	response regulator
HV352_RS00895	COG0814	amino acid
HV352_RS00900	COG0626	cystathionine gamma-synthase activity
HV352_RS00910	COG2199	diguanylate cyclase activity
HV352_RS00910	COG2200	EAL domain
HV352_RS00925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS00930	COG2200	EAL domain
HV352_RS00935	COG2982	Protein involved in outer membrane biogenesis
HV352_RS00940	COG0477	Major facilitator Superfamily
HV352_RS00945	COG1295	ribonuclease BN
HV352_RS00950	COG0583	DNA-binding transcription factor activity
HV352_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS00960	COG2197	response regulator
HV352_RS00970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV352_RS00985	COG1858	cytochrome C peroxidase
HV352_RS00995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV352_RS01000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV352_RS01005	COG0339	signal peptide processing
HV352_RS01020	COG0246	Mannitol dehydrogenase
HV352_RS01025	COG1349	DNA-binding transcription factor activity
HV352_RS01035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS01035	COG2213	PTS system mannitol-specific
HV352_RS01050	COG1959	2 iron, 2 sulfur cluster binding
HV352_RS01060	COG0589	response to stress
HV352_RS01070	COG0306	phosphate transporter
HV352_RS01075	COG2081	HI0933 family
HV352_RS01080	COG2239	Acts as a magnesium transporter
HV352_RS01085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS01090	COG0842	Transport permease protein
HV352_RS01090	COG1129	ABC transporter
HV352_RS01095	COG0842	Transport permease protein
HV352_RS01110	COG3479	Phenolic acid decarboxylase
HV352_RS01115	COG2091	lysine biosynthetic process via aminoadipic acid
HV352_RS01120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV352_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS01135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV352_RS01160	COG1216	Glycosyl transferase, family 2
HV352_RS01180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV352_RS01210	COG0628	permease
HV352_RS01215	COG0477	Major facilitator Superfamily
HV352_RS01225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV352_RS01240	COG3714	YhhN family
HV352_RS01250	COG3776	membrane
HV352_RS01255	COG0742	ribosomal rna small subunit methyltransferase
HV352_RS01260	COG0552	protein localization to endoplasmic reticulum
HV352_RS01265	COG2884	Cell division ATP-binding protein ftsE
HV352_RS01270	COG2177	Part of the ABC transporter FtsEX involved in
HV352_RS01290	COG0683	leucine binding
HV352_RS01300	COG4177	L-phenylalanine transmembrane transporter activity
HV352_RS01305	COG0411	ABC transporter
HV352_RS01310	COG0410	ABC transporter
HV352_RS01340	COG0584	glycerophosphoryl diester phosphodiesterase
HV352_RS01350	COG0405	Gamma-glutamyltransferase
HV352_RS01360	COG1247	-acetyltransferase
HV352_RS01365	COG0673	inositol 2-dehydrogenase activity
HV352_RS01370	COG1741	Belongs to the pirin family
HV352_RS01375	COG1609	Transcriptional regulator
HV352_RS01380	COG3265	gluconokinase activity
HV352_RS01385	COG2610	gluconate transmembrane transporter activity
HV352_RS01390	COG2095	MarC family integral membrane protein
HV352_RS01395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV352_RS01420	COG0058	SHG alpha-glucan phosphorylase activity
HV352_RS01425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV352_RS01440	COG1349	DNA-binding transcription factor activity
HV352_RS01450	COG0058	SHG alpha-glucan phosphorylase activity
HV352_RS01455	COG1640	4-alpha-glucanotransferase
HV352_RS01460	COG2610	gluconate transmembrane transporter activity
HV352_RS01470	COG1040	competence protein
HV352_RS01480	COG5464	transposase or invertase
HV352_RS01495	COG1918	ferrous iron import across plasma membrane
HV352_RS01500	COG2183	response to ionizing radiation
HV352_RS01505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV352_RS01510	COG0745	RESPONSE REGULATOR receiver
HV352_RS01525	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV352_RS01535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV352_RS01540	COG1011	Hydrolase
HV352_RS01550	COG0494	nUDIX hydrolase
HV352_RS01555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV352_RS01560	COG4972	Pilus assembly protein
HV352_RS01580	COG4796	Type ii and iii secretion system protein
HV352_RS01595	COG3266	domain, Protein
HV352_RS01600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV352_RS01605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV352_RS01615	COG0180	Tryptophanyl-tRNA synthetase
HV352_RS01635	COG2146	nitrite reductase [NAD(P)H] activity
HV352_RS01640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV352_RS01665	COG0512	Glutamine amidotransferase of anthranilate synthase
HV352_RS01670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV352_RS01675	COG1289	transmembrane transporter activity
HV352_RS01685	COG1765	OsmC-like protein
HV352_RS01690	COG3954	Phosphoribulokinase
HV352_RS01700	COG0429	hydrolase of the alpha beta-hydrolase fold
HV352_RS01705	COG0488	(ABC) transporter
HV352_RS01720	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV352_RS01725	COG1047	Peptidyl-prolyl cis-trans
HV352_RS01735	COG0545	Peptidyl-prolyl cis-trans isomerase
HV352_RS01740	COG2964	Protein conserved in bacteria
HV352_RS01800	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HV352_RS01805	COG3156	type II secretion system protein K
HV352_RS01810	COG4795	General secretion pathway protein
HV352_RS01815	COG2165	general secretion pathway protein
HV352_RS01820	COG2165	general secretion pathway protein
HV352_RS01825	COG2165	general secretion pathway protein
HV352_RS01830	COG1459	type II secretion system
HV352_RS01835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV352_RS01840	COG1450	Type ii and iii secretion system protein
HV352_RS01860	COG0051	transcription antitermination factor activity, RNA binding
HV352_RS01870	COG0088	Forms part of the polypeptide exit tunnel
HV352_RS01885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV352_RS01960	COG0200	Binds to the 23S rRNA
HV352_RS01965	COG0201	protein transport
HV352_RS01980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV352_RS02005	COG0789	Transcriptional regulator
HV352_RS02010	COG3036	rescue of stalled ribosome
HV352_RS02020	COG0569	domain protein
HV352_RS02040	COG0758	DNA mediated transformation
HV352_RS02050	COG0551	DNA topoisomerase type I activity
HV352_RS02070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV352_RS02110	COG1126	abc transporter atp-binding protein
HV352_RS02115	COG0765	amino acid transport
HV352_RS02120	COG4597	amino acid ABC transporter
HV352_RS02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV352_RS02135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV352_RS02140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS02145	COG1309	transcriptional regulator
HV352_RS02155	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV352_RS02175	COG4145	pantothenate transmembrane transporter activity
HV352_RS02180	COG3924	membrane
HV352_RS02185	COG0439	Biotin carboxylase
HV352_RS02190	COG0511	ligase activity, forming carbon-carbon bonds
HV352_RS02205	COG0604	alcohol dehydrogenase
HV352_RS02210	COG2199	diguanylate cyclase activity
HV352_RS02210	COG2200	EAL domain
HV352_RS02215	COG1077	Cell shape determining protein MreB Mrl
HV352_RS02220	COG1792	Involved in formation and maintenance of cell shape
HV352_RS02225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV352_RS02235	COG1530	ribonuclease E activity
HV352_RS02240	COG3164	Protein of unknown function
HV352_RS02245	COG0312	modulator of DNA gyrase
HV352_RS02250	COG0583	DNA-binding transcription factor activity
HV352_RS02270	COG2732	(Barnase) inhibitor
HV352_RS02290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV352_RS02295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV352_RS02300	COG3105	Protein conserved in bacteria
HV352_RS02305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV352_RS02320	COG0625	glutathione transferase activity
HV352_RS02325	COG2969	positive regulation of protein catabolic process
HV352_RS02330	COG3069	C4-dicarboxylate transmembrane transporter activity
HV352_RS02360	COG2731	YhcH YjgK YiaL family protein
HV352_RS02365	COG0402	S-adenosylhomocysteine deaminase activity
HV352_RS02370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV352_RS02375	COG0493	'glutamate synthase
HV352_RS02380	COG0067	glutamate synthase
HV352_RS02380	COG0069	glutamate synthase activity
HV352_RS02380	COG0070	glutamate synthase
HV352_RS02385	COG1242	4 iron, 4 sulfur cluster binding
HV352_RS02390	COG5002	protein histidine kinase activity
HV352_RS02390	COG2198	Histidine kinase
HV352_RS02390	COG0784	Response regulator, receiver
HV352_RS02395	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV352_RS02405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS02420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV352_RS02430	COG1137	ATPase activity
HV352_RS02435	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV352_RS02440	COG3117	lipopolysaccharide transmembrane transporter activity
HV352_RS02445	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV352_RS02450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV352_RS02450	COG0517	IMP dehydrogenase activity
HV352_RS02455	COG0530	calcium, potassium:sodium antiporter activity
HV352_RS02460	COG1127	ABC transporter
HV352_RS02465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV352_RS02470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV352_RS02475	COG2854	intermembrane phospholipid transfer
HV352_RS02480	COG3113	response to antibiotic
HV352_RS02485	COG5007	Belongs to the BolA IbaG family
HV352_RS02495	COG3423	Transcriptional regulator
HV352_RS02500	COG0142	geranyltranstransferase activity
HV352_RS02505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV352_RS02510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV352_RS02515	COG0697	spore germination
HV352_RS02525	COG2027	D-alanyl-D-alanine carboxypeptidase
HV352_RS02535	COG1534	Rna-binding protein
HV352_RS02545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV352_RS02550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV352_RS02560	COG3069	C4-dicarboxylate transmembrane transporter activity
HV352_RS02565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV352_RS02570	COG0583	DNA-binding transcription factor activity
HV352_RS02575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV352_RS02600	COG0195	Participates in both transcription termination and antitermination
HV352_RS02610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV352_RS02640	COG0513	Belongs to the DEAD box helicase family
HV352_RS02645	COG0814	amino acid
HV352_RS02650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV352_RS02655	COG0826	peptidase U32
HV352_RS02660	COG0826	peptidase U32
HV352_RS02665	COG3154	lipid carrier protein
HV352_RS02670	COG3153	acetyltransferase
HV352_RS02685	COG0702	epimerase
HV352_RS02690	COG2823	Periplasmic or secreted lipoprotein
HV352_RS02705	COG3107	peptidoglycan biosynthetic process
HV352_RS02710	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV352_RS02715	COG0363	glucosamine-6-phosphate deaminase activity
HV352_RS02725	COG3715	PTS system
HV352_RS02730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS02740	COG2222	sugar isomerase
HV352_RS02745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV352_RS02750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS02755	COG3716	PTS system mannose fructose sorbose family IID component
HV352_RS02765	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS02775	COG1349	DNA-binding transcription factor activity
HV352_RS02780	COG2721	sulfolactate sulfo-lyase activity
HV352_RS02785	COG2271	Major facilitator Superfamily
HV352_RS02795	COG2084	Dehydrogenase
HV352_RS02800	COG1929	Belongs to the glycerate kinase type-1 family
HV352_RS02810	COG0583	DNA-binding transcription factor activity
HV352_RS02830	COG1882	Formate acetyltransferase
HV352_RS02835	COG0251	oxidation-reduction process
HV352_RS02840	COG1760	l-serine dehydratase
HV352_RS02845	COG0814	amino acid
HV352_RS02860	COG1741	Belongs to the pirin family
HV352_RS02865	COG0583	DNA-binding transcription factor activity
HV352_RS02870	COG3152	Membrane
HV352_RS02875	COG0435	Glutathione S-transferase
HV352_RS02880	COG2259	Doxx family
HV352_RS02890	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV352_RS02895	COG4575	ribosome binding
HV352_RS02900	COG1422	Protein of unknown function (DUF1090)
HV352_RS02910	COG0586	Pfam SNARE associated Golgi protein
HV352_RS02915	COG2186	Transcriptional regulator
HV352_RS02920	COG2271	Major facilitator Superfamily
HV352_RS02930	COG2721	sulfolactate sulfo-lyase activity
HV352_RS02950	COG0673	inositol 2-dehydrogenase activity
HV352_RS02955	COG1451	nucleotide metabolic process
HV352_RS02965	COG1902	pentaerythritol trinitrate reductase activity
HV352_RS02965	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV352_RS02980	COG1609	Transcriptional regulator
HV352_RS02990	COG1175	transmembrane transport
HV352_RS02995	COG0395	ABC-type sugar transport system, permease component
HV352_RS03000	COG0366	Alpha amylase catalytic
HV352_RS03005	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HV352_RS03010	COG0531	amino acid
HV352_RS03015	COG2731	YhcH YjgK YiaL family protein
HV352_RS03020	COG3250	beta-galactosidase activity
HV352_RS03025	COG1609	Transcriptional regulator
HV352_RS03030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV352_RS03040	COG0840	transmembrane signaling receptor activity
HV352_RS03045	COG1695	Transcriptional regulator
HV352_RS03050	COG2375	cellular response to nickel ion
HV352_RS03060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV352_RS03160	COG0358	DNA primase activity
HV352_RS03165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV352_RS03170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV352_RS03175	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV352_RS03185	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV352_RS03215	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS03220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS03235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV352_RS03250	COG4991	sh3 domain protein
HV352_RS03255	COG3025	triphosphatase activity
HV352_RS03310	COG3384	dioxygenase
HV352_RS03315	COG0754	glutathionylspermidine amidase activity
HV352_RS03330	COG0494	nUDIX hydrolase
HV352_RS03335	COG3151	Protein conserved in bacteria
HV352_RS03340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV352_RS03345	COG3150	esterase
HV352_RS03350	COG0187	DNA topoisomerase II activity
HV352_RS03355	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV352_RS03360	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV352_RS03375	COG3111	PFAM Bacterial OB fold (BOF) protein
HV352_RS03395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV352_RS03410	COG0656	L-ascorbic acid biosynthetic process
HV352_RS03415	COG1979	alcohol dehydrogenase
HV352_RS03420	COG2207	Transcriptional regulator
HV352_RS03425	COG0586	Pfam SNARE associated Golgi protein
HV352_RS03430	COG0626	cystathionine gamma-synthase activity
HV352_RS03440	COG0848	biopolymer transport protein
HV352_RS03460	COG0667	Aldo Keto reductase
HV352_RS03470	COG0840	transmembrane signaling receptor activity
HV352_RS03480	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV352_RS03485	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS03490	COG5557	Pfam Polysulphide reductase, NrfD
HV352_RS03495	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV352_RS03500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV352_RS03505	COG1773	rubredoxin
HV352_RS03515	COG0298	carbon dioxide binding
HV352_RS03520	COG0625	glutathione transferase activity
HV352_RS03525	COG0243	molybdopterin cofactor binding
HV352_RS03530	COG0754	glutathionylspermidine amidase activity
HV352_RS03555	COG2885	chlorophyll binding
HV352_RS03690	COG1846	Transcriptional regulator
HV352_RS03705	COG0412	Dienelactone hydrolase
HV352_RS03710	COG0840	transmembrane signaling receptor activity
HV352_RS03720	COG1811	Na channel or pump
HV352_RS03725	COG1982	Orn Lys Arg decarboxylase major
HV352_RS03730	COG2211	Major facilitator Superfamily
HV352_RS03745	COG1194	a g-specific adenine glycosylase
HV352_RS03755	COG3171	Protein conserved in bacteria
HV352_RS03765	COG0252	asparaginase activity
HV352_RS03775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV352_RS03790	COG0762	integral membrane protein
HV352_RS03795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV352_RS03815	COG2805	Type II/IV secretion system protein
HV352_RS03830	COG0189	ligase activity
HV352_RS03835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV352_RS03840	COG2356	endonuclease I
HV352_RS03845	COG3091	SprT-like family
HV352_RS03850	COG2814	Major facilitator Superfamily
HV352_RS03870	COG1166	arginine decarboxylase activity
HV352_RS03885	COG0501	Belongs to the peptidase M48B family
HV352_RS03890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV352_RS03895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS03900	COG2213	PTS system mannitol-specific
HV352_RS03905	COG1063	alcohol dehydrogenase
HV352_RS03910	COG1494	fructose-1,6-bisphosphatase
HV352_RS03920	COG1072	(Pantothenic acid kinase))
HV352_RS03935	COG0191	fructose-bisphosphate aldolase activity
HV352_RS03940	COG0549	Belongs to the carbamate kinase family
HV352_RS03945	COG2271	Major facilitator Superfamily
HV352_RS03950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV352_RS03955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV352_RS03965	COG0583	DNA-binding transcription factor activity
HV352_RS03970	COG0668	transmembrane transport
HV352_RS03980	COG1279	arginine transmembrane transporter activity
HV352_RS03985	COG2968	Membrane
HV352_RS03990	COG0583	DNA-binding transcription factor activity
HV352_RS03995	COG0427	acetyl-CoA hydrolase
HV352_RS04000	COG1024	Enoyl-CoA hydratase
HV352_RS04005	COG1703	isobutyryl-CoA mutase activity
HV352_RS04010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV352_RS04010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV352_RS04025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV352_RS04030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV352_RS04050	COG0006	proline dipeptidase activity
HV352_RS04055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV352_RS04060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV352_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS04085	COG2723	6-phospho-beta-galactosidase activity
HV352_RS04090	COG1737	Transcriptional regulator
HV352_RS04100	COG1272	protein, Hemolysin III
HV352_RS04110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV352_RS04135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV352_RS04155	COG4942	peptidase
HV352_RS04170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV352_RS04175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV352_RS04180	COG0457	Tetratricopeptide repeat
HV352_RS04185	COG0438	transferase activity, transferring glycosyl groups
HV352_RS04190	COG1596	polysaccharide export
HV352_RS04195	COG1682	transport, permease protein
HV352_RS04200	COG1134	teichoic acid transport
HV352_RS04205	COG3524	carbohydrate:proton symporter activity
HV352_RS04210	COG4783	chaperone-mediated protein folding
HV352_RS04210	COG1560	Kdo2-lipid A biosynthetic process
HV352_RS04220	COG0457	Tetratricopeptide repeat
HV352_RS04225	COG1649	PFAM Uncharacterised BCR, COG1649
HV352_RS04225	COG0726	polysaccharide deacetylase
HV352_RS04230	COG1215	transferase activity, transferring glycosyl groups
HV352_RS04240	COG3592	Divergent 4Fe-4S mono-cluster
HV352_RS04245	COG2388	GCN5-related N-acetyl-transferase
HV352_RS04250	COG0583	DNA-binding transcription factor activity
HV352_RS04255	COG0666	response to abiotic stimulus
HV352_RS04265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV352_RS04270	COG1304	FMN binding
HV352_RS04280	COG0549	Belongs to the carbamate kinase family
HV352_RS04285	COG0402	S-adenosylhomocysteine deaminase activity
HV352_RS04300	COG0814	amino acid
HV352_RS04315	COG0183	Belongs to the thiolase family
HV352_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS04335	COG1794	racemase activity, acting on amino acids and derivatives
HV352_RS04340	COG0583	DNA-binding transcription factor activity
HV352_RS04350	COG1609	Transcriptional regulator
HV352_RS04370	COG0667	Aldo Keto reductase
HV352_RS04380	COG0861	Integral membrane protein TerC family
HV352_RS04410	COG2165	general secretion pathway protein
HV352_RS04415	COG4795	General secretion pathway protein
HV352_RS04425	COG4967	type IV pilus modification protein PilV
HV352_RS04430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV352_RS04440	COG1074	ATP-dependent DNA helicase activity
HV352_RS04445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV352_RS04450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV352_RS04450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV352_RS04455	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV352_RS04475	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV352_RS04480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV352_RS04485	COG2166	iron-sulfur cluster assembly
HV352_RS04490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV352_RS04500	COG0583	DNA-binding transcription factor activity
HV352_RS04505	COG2363	Small membrane protein
HV352_RS04515	COG1349	DNA-binding transcription factor activity
HV352_RS04535	COG1129	ABC transporter
HV352_RS04540	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS04550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV352_RS04560	COG0235	Class ii aldolase
HV352_RS04565	COG1454	alcohol dehydrogenase
HV352_RS04575	COG1760	l-serine dehydratase
HV352_RS04580	COG0814	amino acid
HV352_RS04585	COG1611	Belongs to the LOG family
HV352_RS04600	COG3098	single-species biofilm formation
HV352_RS04605	COG0564	pseudouridine synthase activity
HV352_RS04610	COG0716	FMN binding
HV352_RS04615	COG2271	Major facilitator Superfamily
HV352_RS04620	COG4948	Mandelate Racemase Muconate Lactonizing
HV352_RS04625	COG4948	Mandelate Racemase Muconate Lactonizing
HV352_RS04630	COG1929	Belongs to the glycerate kinase type-1 family
HV352_RS04635	COG3850	Histidine kinase
HV352_RS04635	COG3437	response regulator, receiver
HV352_RS04635	COG4999	Histidine kinase
HV352_RS04635	COG2205	protein histidine kinase activity
HV352_RS04645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV352_RS04650	COG3956	TIGRFAM MazG family protein
HV352_RS04665	COG1737	Transcriptional regulator
HV352_RS04670	COG2190	(PTS) system
HV352_RS04670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS04670	COG1263	PTS System
HV352_RS04675	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV352_RS04680	COG0602	queuosine metabolic process
HV352_RS04685	COG1070	Carbohydrate kinase
HV352_RS04690	COG2223	nitrite transmembrane transporter activity
HV352_RS04695	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS04700	COG0277	FAD linked oxidase domain protein
HV352_RS04705	COG0477	Major facilitator Superfamily
HV352_RS04710	COG2086	electron transfer activity
HV352_RS04715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV352_RS04720	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HV352_RS04725	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV352_RS04730	COG0644	oxidoreductase
HV352_RS04735	COG0720	synthase
HV352_RS04755	COG2234	aminopeptidase activity
HV352_RS04810	COG1388	LysM domain
HV352_RS04810	COG4942	peptidase
HV352_RS04845	COG2200	EAL domain
HV352_RS04850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV352_RS04855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV352_RS04860	COG1121	(ABC) transporter
HV352_RS04880	COG0309	Hydrogenase expression formation protein (HypE)
HV352_RS04885	COG0409	Hydrogenase expression formation protein
HV352_RS04890	COG0298	carbon dioxide binding
HV352_RS04895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV352_RS04910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV352_RS04915	COG0651	ATP synthesis coupled electron transport
HV352_RS04920	COG0650	Formate hydrogenlyase subunit 4
HV352_RS04925	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV352_RS04925	COG3261	NADH dehydrogenase
HV352_RS04930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV352_RS04935	COG3260	NADH ubiquinone oxidoreductase 20
HV352_RS04945	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV352_RS04960	COG2723	6-phospho-beta-galactosidase activity
HV352_RS04965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS04965	COG1263	PTS System
HV352_RS04970	COG1609	Transcriptional regulator
HV352_RS04975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV352_RS04980	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV352_RS05000	COG0517	IMP dehydrogenase activity
HV352_RS05000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV352_RS05005	COG1349	DNA-binding transcription factor activity
HV352_RS05010	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS05015	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS05025	COG3732	PTS system glucitol sorbitol-specific
HV352_RS05030	COG3730	PTS system glucitol sorbitol-specific
HV352_RS05035	COG2951	lytic endotransglycosylase activity
HV352_RS05040	COG1546	Belongs to the CinA family
HV352_RS05060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV352_RS05090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV352_RS05095	COG1238	metal cluster binding
HV352_RS05110	COG2814	Major facilitator Superfamily
HV352_RS05115	COG1566	PFAM secretion protein HlyD family protein
HV352_RS05120	COG1846	Transcriptional regulator
HV352_RS05130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV352_RS05135	COG2814	Major facilitator Superfamily
HV352_RS05145	COG4176	ABC-type proline glycine betaine transport system permease component
HV352_RS05175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV352_RS05205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV352_RS05210	COG0640	Transcriptional regulator
HV352_RS05215	COG0401	homolog of Blt101
HV352_RS05220	COG1652	LysM domain
HV352_RS05225	COG1802	Transcriptional regulator
HV352_RS05230	COG1113	amino acid transport
HV352_RS05235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV352_RS05240	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS05245	COG0579	oxidoreductase
HV352_RS05255	COG1285	pathogenesis
HV352_RS05260	COG2211	Major facilitator Superfamily
HV352_RS05305	COG0642	Histidine kinase
HV352_RS05315	COG3188	usher protein
HV352_RS05320	COG3121	Chaperone
HV352_RS05365	COG0438	transferase activity, transferring glycosyl groups
HV352_RS05370	COG0438	transferase activity, transferring glycosyl groups
HV352_RS05370	COG0297	glycogen (starch) synthase activity
HV352_RS05400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV352_RS05405	COG1757	Na H antiporter
HV352_RS05410	COG2169	Transcriptional regulator
HV352_RS05425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV352_RS05430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV352_RS05435	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV352_RS05440	COG2271	Major facilitator Superfamily
HV352_RS05445	COG2197	response regulator
HV352_RS05450	COG2198	Histidine kinase
HV352_RS05450	COG0784	Response regulator, receiver
HV352_RS05450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV352_RS05450	COG2205	protein histidine kinase activity
HV352_RS05470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV352_RS05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS05480	COG3065	identical protein binding
HV352_RS05500	COG2200	EAL domain
HV352_RS05525	COG4974	Belongs to the 'phage' integrase family
HV352_RS05560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV352_RS05595	COG4695	Portal protein
HV352_RS05685	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV352_RS05690	COG3274	enterobacterial common antigen metabolic process
HV352_RS05740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS05765	COG2867	negative regulation of translational initiation
HV352_RS05780	COG0497	DNA recombination
HV352_RS05795	COG4536	flavin adenine dinucleotide binding
HV352_RS05800	COG4137	Cytochrome C assembly protein
HV352_RS05805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV352_RS05830	COG2885	chlorophyll binding
HV352_RS05835	COG2199	diguanylate cyclase activity
HV352_RS05850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV352_RS05855	COG1605	Chorismate mutase
HV352_RS05855	COG0287	Prephenate dehydrogenase
HV352_RS05860	COG0077	Prephenate dehydratase
HV352_RS05860	COG1605	Chorismate mutase
HV352_RS05870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV352_RS05875	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV352_RS05890	COG0542	response to heat
HV352_RS05920	COG0477	Major facilitator Superfamily
HV352_RS05925	COG5544	Lipoprotein
HV352_RS05930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV352_RS05945	COG3118	belongs to the thioredoxin family
HV352_RS05950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV352_RS05965	COG0513	Belongs to the DEAD box helicase family
HV352_RS05975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV352_RS05985	COG1595	DNA-templated transcription, initiation
HV352_RS05995	COG3026	antisigma factor binding
HV352_RS06000	COG3086	response to oxidative stress
HV352_RS06010	COG0681	Belongs to the peptidase S26 family
HV352_RS06030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV352_RS06040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV352_RS06045	COG1737	Transcriptional regulator
HV352_RS06050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV352_RS06055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS06055	COG1263	PTS System
HV352_RS06060	COG0560	Phosphoserine phosphatase
HV352_RS06080	COG2205	protein histidine kinase activity
HV352_RS06085	COG3170	Tfp pilus assembly protein FimV
HV352_RS06090	COG2204	response regulator
HV352_RS06095	COG0347	Belongs to the P(II) protein family
HV352_RS06100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV352_RS06100	COG1017	nitric oxide dioxygenase activity
HV352_RS06130	COG4638	Rieske (2fe-2S)
HV352_RS06135	COG0583	DNA-binding transcription factor activity
HV352_RS06140	COG3539	Fimbrial protein
HV352_RS06145	COG3188	usher protein
HV352_RS06150	COG3121	Chaperone
HV352_RS06155	COG3539	Fimbrial protein
HV352_RS06160	COG2814	Major facilitator Superfamily
HV352_RS06165	COG3711	transcriptional antiterminator
HV352_RS06170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV352_RS06170	COG0517	IMP dehydrogenase activity
HV352_RS06175	COG1069	ribulokinase activity
HV352_RS06185	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS06190	COG1129	ABC transporter
HV352_RS06200	COG3683	transport system, periplasmic component
HV352_RS06205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV352_RS06230	COG0822	iron-sulfur transferase activity
HV352_RS06250	COG0633	Ferredoxin
HV352_RS06255	COG2975	iron-sulfur cluster assembly
HV352_RS06270	COG2897	thiosulfate sulfurtransferase activity
HV352_RS06275	COG2373	Large extracellular alpha-helical protein
HV352_RS06280	COG4953	penicillin-binding protein 1C
HV352_RS06310	COG2976	Protein conserved in bacteria
HV352_RS06325	COG3104	oligopeptide transport
HV352_RS06335	COG1645	bacterial-type flagellum-dependent swarming motility
HV352_RS06340	COG1570	exodeoxyribonuclease VII activity
HV352_RS06345	COG0517	IMP dehydrogenase activity
HV352_RS06345	COG0516	GMP reductase activity
HV352_RS06360	COG2200	EAL domain
HV352_RS06375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV352_RS06385	COG2723	6-phospho-beta-galactosidase activity
HV352_RS06395	COG2233	PERMEase
HV352_RS06405	COG1393	Belongs to the ArsC family
HV352_RS06410	COG4783	chaperone-mediated protein folding
HV352_RS06415	COG0628	permease
HV352_RS06420	COG3366	ferrous iron transmembrane transporter activity
HV352_RS06425	COG0700	Nucleoside recognition
HV352_RS06430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV352_RS06435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV352_RS06440	COG2716	regulation of RNA biosynthetic process
HV352_RS06450	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV352_RS06460	COG2321	neutral zinc metallopeptidase
HV352_RS06470	COG0400	carboxylic ester hydrolase activity
HV352_RS06485	COG1393	Belongs to the ArsC family
HV352_RS06495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV352_RS06500	COG3850	Histidine kinase
HV352_RS06505	COG0493	'glutamate synthase
HV352_RS06505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV352_RS06515	COG5342	invasion associated locus B
HV352_RS06520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV352_RS06540	COG4766	ethanolamine catabolic process
HV352_RS06545	COG4812	Cobalamin adenosyltransferase
HV352_RS06610	COG2207	Transcriptional regulator
HV352_RS06620	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV352_RS06640	COG2837	iron assimilation
HV352_RS06645	COG0165	Argininosuccinate lyase
HV352_RS06650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV352_RS06655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV352_RS06660	COG2186	Transcriptional regulator
HV352_RS06670	COG4150	thiosulfate binding
HV352_RS06675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV352_RS06680	COG4208	sulfate ABC transporter
HV352_RS06685	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV352_RS06750	COG3530	Putative quorum-sensing-regulated virulence factor
HV352_RS06755	COG0385	Bile acid
HV352_RS06760	COG0583	DNA-binding transcription factor activity
HV352_RS06790	COG3415	Transposase
HV352_RS06795	COG3415	Transposase
HV352_RS06810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV352_RS06825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV352_RS06830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV352_RS06835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS06835	COG1263	PTS System
HV352_RS06845	COG0667	Aldo Keto reductase
HV352_RS06850	COG3961	Belongs to the TPP enzyme family
HV352_RS06865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS06870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS06875	COG0006	proline dipeptidase activity
HV352_RS06880	COG1363	Peptidase, m42
HV352_RS06895	COG2207	Transcriptional regulator
HV352_RS06900	COG3279	Response regulator of the LytR AlgR family
HV352_RS06905	COG3275	phosphorelay sensor kinase activity
HV352_RS06910	COG0436	Aminotransferase
HV352_RS06925	COG1560	Kdo2-lipid A biosynthetic process
HV352_RS06955	COG3122	Protein conserved in bacteria
HV352_RS06960	COG0840	transmembrane signaling receptor activity
HV352_RS06965	COG1446	asparaginase
HV352_RS06980	COG0582	viral genome integration into host DNA
HV352_RS07105	COG1403	HNH endonuclease
HV352_RS07130	COG3179	chitinase
HV352_RS07160	COG1802	Transcriptional regulator
HV352_RS07160	COG4626	Terminase
HV352_RS07210	COG4386	tail sheath protein
HV352_RS07235	COG4228	DNA circulation
HV352_RS07255	COG3299	homolog of phage Mu protein gp47
HV352_RS07260	COG3778	Protein conserved in bacteria
HV352_RS07290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV352_RS07295	COG2116	formate transmembrane transporter activity
HV352_RS07305	COG2067	long-chain fatty acid transport protein
HV352_RS07310	COG3691	Protein conserved in bacteria
HV352_RS07325	COG2062	phosphohistidine phosphatase, SixA
HV352_RS07350	COG0730	response to heat
HV352_RS07355	COG3101	peptidyl-lysine hydroxylation
HV352_RS07370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV352_RS07410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV352_RS07420	COG0586	Pfam SNARE associated Golgi protein
HV352_RS07430	COG0285	dihydrofolate synthase activity
HV352_RS07435	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV352_RS07440	COG1286	toxin biosynthetic process
HV352_RS07445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV352_RS07450	COG0163	prenyltransferase activity
HV352_RS07460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV352_RS07475	COG4598	ABC transporter
HV352_RS07480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV352_RS07485	COG1090	epimerase
HV352_RS07490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV352_RS07495	COG0625	glutathione transferase activity
HV352_RS07500	COG0625	glutathione transferase activity
HV352_RS07505	COG0622	Phosphoesterase
HV352_RS07515	COG1288	antiporter activity
HV352_RS07540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV352_RS07545	COG0471	metal ion transport
HV352_RS07545	COG0490	domain, Protein
HV352_RS07555	COG0436	Aminotransferase
HV352_RS07560	COG0583	DNA-binding transcription factor activity
HV352_RS07580	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV352_RS07605	COG0839	Belongs to the complex I subunit 6 family
HV352_RS07615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV352_RS07620	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV352_RS07630	COG0784	Response regulator, receiver
HV352_RS07630	COG0835	chemotaxis
HV352_RS07640	COG2153	protein acetylation
HV352_RS07645	COG4575	ribosome binding
HV352_RS07650	COG1169	isochorismate synthase
HV352_RS07735	COG1414	Transcriptional regulator
HV352_RS07745	COG2271	Major facilitator Superfamily
HV352_RS07765	COG0247	lactate metabolic process
HV352_RS07775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV352_RS07780	COG2271	Major facilitator Superfamily
HV352_RS07785	COG0584	glycerophosphoryl diester phosphodiesterase
HV352_RS07790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV352_RS07815	COG0183	Belongs to the thiolase family
HV352_RS07820	COG2031	fatty acid transporter
HV352_RS07825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV352_RS07830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV352_RS07835	COG2204	response regulator
HV352_RS07840	COG3852	Histidine kinase
HV352_RS07855	COG0642	Histidine kinase
HV352_RS07855	COG2198	Histidine kinase
HV352_RS07865	COG1477	protein flavinylation
HV352_RS07870	COG2169	Transcriptional regulator
HV352_RS07870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV352_RS07875	COG3145	DNA-N1-methyladenine dioxygenase activity
HV352_RS07880	COG4615	Cyclic peptide transporter
HV352_RS07885	COG2239	Acts as a magnesium transporter
HV352_RS07890	COG0659	secondary active sulfate transmembrane transporter activity
HV352_RS07905	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV352_RS07905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV352_RS07910	COG3062	negative regulation of establishment of protein localization
HV352_RS07920	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS07925	COG0348	domain, Protein
HV352_RS07930	COG3043	anaerobic respiration
HV352_RS07935	COG3005	denitrification pathway
HV352_RS07940	COG4133	protoheme IX ABC transporter activity
HV352_RS07950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV352_RS07955	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV352_RS07965	COG1138	Cytochrome C-type biogenesis protein
HV352_RS07970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV352_RS07975	COG4235	cytochrome complex assembly
HV352_RS07975	COG3088	subunit of a heme lyase
HV352_RS07980	COG2197	response regulator
HV352_RS08010	COG1061	Type III restriction enzyme res subunit
HV352_RS08015	COG1187	pseudouridine synthase activity
HV352_RS08020	COG2814	Major facilitator Superfamily
HV352_RS08030	COG4172	Belongs to the ABC transporter superfamily
HV352_RS08035	COG4239	(ABC) transporter, permease
HV352_RS08040	COG4174	ABC transporter (Permease)
HV352_RS08045	COG4166	transmembrane transport
HV352_RS08050	COG2200	EAL domain
HV352_RS08055	COG0791	NLP P60 protein
HV352_RS08060	COG0671	phosphoesterase, PA-phosphatase related
HV352_RS08065	COG0523	cobalamin synthesis protein
HV352_RS08070	COG0246	Mannitol dehydrogenase
HV352_RS08075	COG1312	Catalyzes the dehydration of D-mannonate
HV352_RS08080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV352_RS08085	COG3005	denitrification pathway
HV352_RS08095	COG3381	protein complex oligomerization
HV352_RS08120	COG1105	Belongs to the carbohydrate kinase PfkB family
HV352_RS08125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS08125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS08125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV352_RS08130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV352_RS08140	COG0583	DNA-binding transcription factor activity
HV352_RS08145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS08150	COG2313	pseudouridylate synthase activity
HV352_RS08155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV352_RS08160	COG1522	sequence-specific DNA binding
HV352_RS08160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS08170	COG2855	membrane
HV352_RS08175	COG0583	DNA-binding transcription factor activity
HV352_RS08180	COG0833	amino acid
HV352_RS08185	COG4771	TonB-dependent receptor
HV352_RS08200	COG2311	Membrane
HV352_RS08215	COG1129	ABC transporter
HV352_RS08230	COG0493	'glutamate synthase
HV352_RS08240	COG2949	membrane
HV352_RS08250	COG1346	cytolysis
HV352_RS08265	COG2271	Major facilitator Superfamily
HV352_RS08280	COG0625	glutathione transferase activity
HV352_RS08285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV352_RS08290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV352_RS08305	COG0586	Pfam SNARE associated Golgi protein
HV352_RS08315	COG1686	Belongs to the peptidase S11 family
HV352_RS08320	COG0277	FAD linked oxidase domain protein
HV352_RS08325	COG1472	Belongs to the glycosyl hydrolase 3 family
HV352_RS08330	COG1732	Glycine betaine
HV352_RS08335	COG1174	glycine betaine transport
HV352_RS08340	COG1125	glycine betaine transport
HV352_RS08345	COG1174	glycine betaine transport
HV352_RS08355	COG0789	Transcriptional regulator
HV352_RS08360	COG3275	phosphorelay sensor kinase activity
HV352_RS08370	COG4807	Protein conserved in bacteria
HV352_RS08375	COG4808	Protein conserved in bacteria
HV352_RS08400	COG3121	Chaperone
HV352_RS08405	COG3188	usher protein
HV352_RS08415	COG5455	response to cobalt ion
HV352_RS08425	COG0351	phosphomethylpyrimidine kinase
HV352_RS08430	COG2188	Transcriptional regulator
HV352_RS08435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS08440	COG1397	ADP-ribosylglycohydrolase
HV352_RS08445	COG2211	Major facilitator Superfamily
HV352_RS08450	COG1830	Aldolase
HV352_RS08460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV352_RS08465	COG4160	amino acid transport
HV352_RS08470	COG4215	(ABC) transporter
HV352_RS08475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV352_RS08480	COG1126	abc transporter atp-binding protein
HV352_RS08495	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV352_RS08500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV352_RS08505	COG0702	epimerase
HV352_RS08510	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV352_RS08515	COG0028	Belongs to the TPP enzyme family
HV352_RS08525	COG4529	Protein conserved in bacteria
HV352_RS08530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV352_RS08540	COG2431	L-lysine efflux transmembrane transporter activity
HV352_RS08550	COG3593	DNA synthesis involved in DNA repair
HV352_RS08555	COG2990	Protein conserved in bacteria
HV352_RS08560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS08570	COG1278	Cold shock
HV352_RS08580	COG0542	response to heat
HV352_RS08595	COG0745	RESPONSE REGULATOR receiver
HV352_RS08600	COG2205	protein histidine kinase activity
HV352_RS08630	COG0443	Heat shock 70 kDa protein
HV352_RS08635	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV352_RS08640	COG5002	protein histidine kinase activity
HV352_RS08640	COG5001	Diguanylate cyclase
HV352_RS08640	COG3447	MASE1 domain protein
HV352_RS08655	COG2982	Protein involved in outer membrane biogenesis
HV352_RS08660	COG1253	flavin adenine dinucleotide binding
HV352_RS08680	COG0463	Glycosyl transferase, family 2
HV352_RS08685	COG1045	serine acetyltransferase
HV352_RS08690	COG0438	transferase activity, transferring glycosyl groups
HV352_RS08700	COG1216	Glycosyl transferase, family 2
HV352_RS08705	COG0110	maltose O-acetyltransferase activity
HV352_RS08710	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV352_RS08715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV352_RS08720	COG1051	belongs to the nudix hydrolase family
HV352_RS08725	COG0297	glycogen (starch) synthase activity
HV352_RS08730	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HV352_RS08730	COG0662	Cupin 2, conserved barrel domain protein
HV352_RS08735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV352_RS08740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV352_RS08745	COG2244	polysaccharide biosynthetic process
HV352_RS08750	COG2327	Polysaccharide pyruvyl transferase
HV352_RS08770	COG1091	dTDP-4-dehydrorhamnose reductase activity
HV352_RS08780	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HV352_RS08780	COG0463	Glycosyl transferase, family 2
HV352_RS08785	COG1682	transport, permease protein
HV352_RS08800	COG0438	transferase activity, transferring glycosyl groups
HV352_RS08805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV352_RS08820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HV352_RS08840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV352_RS08870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV352_RS08875	COG0583	DNA-binding transcription factor activity
HV352_RS08885	COG0531	amino acid
HV352_RS08890	COG2925	Exonuclease
HV352_RS08920	COG1289	transmembrane transporter activity
HV352_RS08955	COG4656	Part of a membrane complex involved in electron transport
HV352_RS08965	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS09145	COG1376	ErfK ybiS ycfS ynhG family protein
HV352_RS09155	COG1178	ABC-type Fe3 transport system permease component
HV352_RS09160	COG1840	ABC-type Fe3 transport system, periplasmic component
HV352_RS09180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV352_RS09185	COG1418	mRNA catabolic process
HV352_RS09190	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV352_RS09195	COG3727	T/G mismatch-specific endonuclease activity
HV352_RS09200	COG0697	spore germination
HV352_RS09205	COG2354	Protein conserved in bacteria
HV352_RS09210	COG5475	Uncharacterized small protein (DUF2158)
HV352_RS09270	COG2882	bacterial-type flagellum organization
HV352_RS09300	COG0425	Belongs to the sulfur carrier protein TusA family
HV352_RS09315	COG0366	Alpha amylase catalytic
HV352_RS09375	COG2197	response regulator
HV352_RS09385	COG2197	response regulator
HV352_RS09420	COG1278	Cold shock
HV352_RS09430	COG0431	NADPH-dependent FMN reductase
HV352_RS09435	COG0640	Transcriptional regulator
HV352_RS09470	COG1305	Transglutaminase-like
HV352_RS09480	COG2608	mercury ion transmembrane transporter activity
HV352_RS09485	COG3012	SEC-C Motif Domain Protein
HV352_RS09485	COG3318	Belongs to the UPF0149 family
HV352_RS09490	COG0814	amino acid
HV352_RS09500	COG1528	Iron-storage protein
HV352_RS09515	COG0477	Major facilitator Superfamily
HV352_RS09525	COG1528	Iron-storage protein
HV352_RS09535	COG1879	ABC-type sugar transport system periplasmic component
HV352_RS09540	COG1129	ABC transporter
HV352_RS09545	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS09590	COG0835	chemotaxis
HV352_RS09595	COG1301	dicarboxylic acid transport
HV352_RS09605	COG0840	transmembrane signaling receptor activity
HV352_RS09620	COG0745	RESPONSE REGULATOR receiver
HV352_RS09630	COG4977	sequence-specific DNA binding
HV352_RS09635	COG2814	Major facilitator Superfamily
HV352_RS09640	COG3250	beta-galactosidase activity
HV352_RS09665	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV352_RS09680	COG3102	Protein conserved in bacteria
HV352_RS09700	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV352_RS09705	COG1801	Protein of unknown function DUF72
HV352_RS09710	COG1335	isochorismatase
HV352_RS09720	COG0494	nUDIX hydrolase
HV352_RS09740	COG2255	four-way junction helicase activity
HV352_RS09745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV352_RS09765	COG1187	pseudouridine synthase activity
HV352_RS09770	COG0538	isocitrate dehydrogenase activity
HV352_RS09775	COG2814	Major facilitator Superfamily
HV352_RS09780	COG1414	Transcriptional regulator
HV352_RS09810	COG0768	penicillin binding
HV352_RS09815	COG2226	methyltransferase
HV352_RS09830	COG3716	PTS system mannose fructose sorbose family IID component
HV352_RS09835	COG3715	PTS system
HV352_RS09840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS09840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS09845	COG1253	flavin adenine dinucleotide binding
HV352_RS09850	COG2200	EAL domain
HV352_RS09855	COG1760	l-serine dehydratase
HV352_RS09875	COG0251	oxidation-reduction process
HV352_RS09880	COG1199	ATP-dependent helicase activity
HV352_RS09885	COG1214	PFAM Peptidase M22, glycoprotease
HV352_RS09890	COG3065	identical protein binding
HV352_RS09895	COG0318	PFAM AMP-dependent synthetase and ligase
HV352_RS09900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV352_RS09905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV352_RS09910	COG4638	Rieske (2fe-2S)
HV352_RS09915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV352_RS09920	COG0473	3-isopropylmalate dehydrogenase activity
HV352_RS09925	COG0583	DNA-binding transcription factor activity
HV352_RS09935	COG2894	cell division
HV352_RS09950	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV352_RS09980	COG2719	SpoVR family
HV352_RS09990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV352_RS10000	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV352_RS10025	COG0157	Belongs to the NadC ModD family
HV352_RS10030	COG0500	methyltransferase
HV352_RS10035	COG1120	ATPase activity
HV352_RS10060	COG1461	Dihydroxyacetone kinase
HV352_RS10065	COG2376	Dihydroxyacetone kinase
HV352_RS10070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV352_RS10095	COG0789	Transcriptional regulator
HV352_RS10100	COG2200	EAL domain
HV352_RS10130	COG0702	epimerase
HV352_RS10140	COG0667	Aldo Keto reductase
HV352_RS10145	COG0656	L-ascorbic acid biosynthetic process
HV352_RS10150	COG0641	radical SAM
HV352_RS10155	COG1263	PTS System
HV352_RS10155	COG2190	(PTS) system
HV352_RS10155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS10170	COG1737	Transcriptional regulator
HV352_RS10175	COG2149	membrane
HV352_RS10195	COG1609	Transcriptional regulator
HV352_RS10200	COG2211	Major facilitator Superfamily
HV352_RS10205	COG1621	beta-fructofuranosidase activity
HV352_RS10215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS10230	COG0300	oxidoreductase activity
HV352_RS10240	COG0204	Acyl-transferase
HV352_RS10240	COG0318	PFAM AMP-dependent synthetase and ligase
HV352_RS10275	COG5002	protein histidine kinase activity
HV352_RS10290	COG0012	GTP binding
HV352_RS10305	COG0527	aspartate kinase activity
HV352_RS10310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV352_RS10315	COG0076	glutamate decarboxylase activity
HV352_RS10320	COG0659	secondary active sulfate transmembrane transporter activity
HV352_RS10350	COG2890	protein-(glutamine-N5) methyltransferase activity
HV352_RS10355	COG3094	Invasion gene expression up-regulator, SirB
HV352_RS10370	COG0387	Pfam Sodium calcium exchanger
HV352_RS10375	COG4572	Cation transport regulator
HV352_RS10380	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV352_RS10390	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV352_RS10395	COG4932	domain protein
HV352_RS10400	COG2197	response regulator
HV352_RS10405	COG3850	Histidine kinase
HV352_RS10410	COG2223	nitrite transmembrane transporter activity
HV352_RS10415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV352_RS10420	COG1140	nitrate reductase beta subunit
HV352_RS10425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV352_RS10430	COG2181	nitrate reductase activity
HV352_RS10465	COG0788	formyltetrahydrofolate deformylase activity
HV352_RS10475	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV352_RS10480	COG0745	RESPONSE REGULATOR receiver
HV352_RS10485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV352_RS10495	COG1435	thymidine kinase activity
HV352_RS10500	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS10500	COG1454	alcohol dehydrogenase
HV352_RS10505	COG2095	MarC family integral membrane protein
HV352_RS10525	COG0444	Belongs to the ABC transporter superfamily
HV352_RS10535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV352_RS10555	COG2350	Protein conserved in bacteria
HV352_RS10595	COG3047	cAMP biosynthetic process
HV352_RS10605	COG3706	GGDEF domain
HV352_RS10645	COG0009	L-threonylcarbamoyladenylate synthase
HV352_RS10650	COG1187	pseudouridine synthase activity
HV352_RS10660	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS10665	COG0616	signal peptide processing
HV352_RS10680	COG0583	DNA-binding transcription factor activity
HV352_RS10695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV352_RS10705	COG0671	phosphoesterase, PA-phosphatase related
HV352_RS10710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV352_RS10715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV352_RS10725	COG0023	Translation Initiation Factor
HV352_RS10735	COG1349	DNA-binding transcription factor activity
HV352_RS10745	COG5001	Diguanylate cyclase
HV352_RS10755	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV352_RS10755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV352_RS10760	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV352_RS10775	COG4172	Belongs to the ABC transporter superfamily
HV352_RS10780	COG4171	peptide transport system, permease
HV352_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS10800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV352_RS10805	COG1842	Phage shock protein A
HV352_RS10815	COG1983	PspC domain protein
HV352_RS10825	COG0366	Alpha amylase catalytic
HV352_RS10830	COG1653	transport
HV352_RS10835	COG1175	transmembrane transport
HV352_RS10840	COG0395	ABC-type sugar transport system, permease component
HV352_RS10845	COG1063	alcohol dehydrogenase
HV352_RS10850	COG1082	Xylose isomerase domain protein TIM barrel
HV352_RS10855	COG0673	inositol 2-dehydrogenase activity
HV352_RS10860	COG1554	hydrolase, family 65, central catalytic
HV352_RS10865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV352_RS10880	COG1609	Transcriptional regulator
HV352_RS10885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV352_RS10890	COG3106	COG3106 Predicted ATPase
HV352_RS10905	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV352_RS10910	COG4948	Mandelate Racemase Muconate Lactonizing
HV352_RS10915	COG2866	Carboxypeptidase
HV352_RS10920	COG4166	transmembrane transport
HV352_RS10925	COG1349	DNA-binding transcription factor activity
HV352_RS10930	COG0346	lactoylglutathione lyase activity
HV352_RS10945	COG0668	transmembrane transport
HV352_RS10950	COG3182	Iron-regulated membrane protein
HV352_RS10970	COG2840	Smr protein MutS2
HV352_RS10975	COG3706	GGDEF domain
HV352_RS10985	COG0840	transmembrane signaling receptor activity
HV352_RS11000	COG0513	Belongs to the DEAD box helicase family
HV352_RS11010	COG0589	response to stress
HV352_RS11020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV352_RS11025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV352_RS11025	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV352_RS11025	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV352_RS11025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV352_RS11030	COG3042	response to heat
HV352_RS11035	COG3187	Heat shock protein
HV352_RS11040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV352_RS11045	COG2911	Protein conserved in bacteria
HV352_RS11055	COG3784	Protein of unknown function (DUF1318)
HV352_RS11070	COG1643	Atp-dependent helicase
HV352_RS11075	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV352_RS11080	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS11085	COG3038	cytochrome b561
HV352_RS11090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV352_RS11095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV352_RS11115	COG0840	transmembrane signaling receptor activity
HV352_RS11120	COG0583	DNA-binding transcription factor activity
HV352_RS11125	COG1227	inorganic diphosphatase activity
HV352_RS11130	COG5383	Protein conserved in bacteria
HV352_RS11140	COG2841	Protein conserved in bacteria
HV352_RS11145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV352_RS11150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV352_RS11155	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV352_RS11160	COG0500	methyltransferase
HV352_RS11180	COG3135	benzoate transporter
HV352_RS11185	COG1396	sequence-specific DNA binding
HV352_RS11190	COG0826	peptidase U32
HV352_RS11205	COG1294	oxidase, subunit
HV352_RS11210	COG1271	oxidase subunit
HV352_RS11215	COG1724	mRNA binding
HV352_RS11220	COG1598	PFAM Uncharacterised protein family UPF0150
HV352_RS11225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV352_RS11230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV352_RS11235	COG3842	ATPase activity
HV352_RS11240	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV352_RS11245	COG1177	transmembrane transport
HV352_RS11255	COG2814	Major facilitator Superfamily
HV352_RS11290	COG0747	negative chemotaxis
HV352_RS11300	COG3238	Protein conserved in bacteria
HV352_RS11305	COG1247	-acetyltransferase
HV352_RS11315	COG2130	NADP-dependent
HV352_RS11320	COG4772	TonB-dependent receptor
HV352_RS11340	COG0840	transmembrane signaling receptor activity
HV352_RS11345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV352_RS11350	COG1473	amidohydrolase
HV352_RS11355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV352_RS11360	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV352_RS11375	COG1126	abc transporter atp-binding protein
HV352_RS11380	COG0625	glutathione transferase activity
HV352_RS11385	COG2271	Major facilitator Superfamily
HV352_RS11405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV352_RS11410	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV352_RS11415	COG0384	phenazine biosynthesis protein PhzF
HV352_RS11420	COG2181	nitrate reductase activity
HV352_RS11425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV352_RS11430	COG1140	nitrate reductase beta subunit
HV352_RS11435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV352_RS11440	COG2223	nitrite transmembrane transporter activity
HV352_RS11475	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS11480	COG2864	formate dehydrogenase
HV352_RS11500	COG1764	response to oxidative stress
HV352_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS11510	COG2610	gluconate transmembrane transporter activity
HV352_RS11515	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV352_RS11515	COG0824	Thioesterase
HV352_RS11525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV352_RS11530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV352_RS11540	COG4608	Belongs to the ABC transporter superfamily
HV352_RS11545	COG0444	Belongs to the ABC transporter superfamily
HV352_RS11550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV352_RS11555	COG0601	transmembrane transport
HV352_RS11560	COG0747	negative chemotaxis
HV352_RS11565	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV352_RS11580	COG0840	transmembrane signaling receptor activity
HV352_RS11590	COG4628	conserved protein (DUF2132)
HV352_RS11610	COG3781	membrane
HV352_RS11635	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS11640	COG0583	DNA-binding transcription factor activity
HV352_RS11655	COG1846	Transcriptional regulator
HV352_RS11670	COG0697	spore germination
HV352_RS11675	COG2814	Major facilitator Superfamily
HV352_RS11685	COG1122	ATPase activity
HV352_RS11710	COG0339	signal peptide processing
HV352_RS11715	COG4221	oxidoreductase activity
HV352_RS11720	COG1802	Transcriptional regulator
HV352_RS11730	COG0246	Mannitol dehydrogenase
HV352_RS11740	COG4948	Mandelate Racemase Muconate Lactonizing
HV352_RS11755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV352_RS11770	COG0243	molybdopterin cofactor binding
HV352_RS11775	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS11780	COG3302	dmso reductase anchor subunit
HV352_RS11785	COG3381	protein complex oligomerization
HV352_RS11795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV352_RS11800	COG1940	carbohydrate kinase activity
HV352_RS11805	COG0583	DNA-binding transcription factor activity
HV352_RS11810	COG2814	Major facilitator Superfamily
HV352_RS11820	COG5002	protein histidine kinase activity
HV352_RS11825	COG0745	RESPONSE REGULATOR receiver
HV352_RS11840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV352_RS11850	COG3591	Belongs to the peptidase S1B family
HV352_RS11865	COG0628	permease
HV352_RS11870	COG2814	Major facilitator Superfamily
HV352_RS11875	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV352_RS11880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV352_RS11890	COG0531	amino acid
HV352_RS11900	COG3136	membrane protein required for alginate biosynthesis
HV352_RS11905	COG0745	RESPONSE REGULATOR receiver
HV352_RS11910	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV352_RS11920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV352_RS11930	COG2205	protein histidine kinase activity
HV352_RS11945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS11945	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS11950	COG1482	cell wall glycoprotein biosynthetic process
HV352_RS11955	COG5339	Protein conserved in bacteria
HV352_RS11960	COG1609	Transcriptional regulator
HV352_RS11965	COG1263	PTS System
HV352_RS11965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS11970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV352_RS11980	COG0673	inositol 2-dehydrogenase activity
HV352_RS12030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV352_RS12040	COG0625	glutathione transferase activity
HV352_RS12045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV352_RS12060	COG3895	Periplasmic Protein
HV352_RS12085	COG1566	PFAM secretion protein HlyD family protein
HV352_RS12100	COG4989	oxidoreductase activity
HV352_RS12105	COG3313	Fe-S protein
HV352_RS12110	COG1309	transcriptional regulator
HV352_RS12115	COG1902	pentaerythritol trinitrate reductase activity
HV352_RS12120	COG0346	lactoylglutathione lyase activity
HV352_RS12130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV352_RS12135	COG0791	NLP P60 protein
HV352_RS12140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV352_RS12145	COG2814	Major facilitator Superfamily
HV352_RS12160	COG0583	DNA-binding transcription factor activity
HV352_RS12165	COG2814	Major facilitator Superfamily
HV352_RS12170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV352_RS12175	COG0307	riboflavin synthase, alpha
HV352_RS12185	COG0564	pseudouridine synthase activity
HV352_RS12200	COG0251	oxidation-reduction process
HV352_RS12225	COG3300	MHYT domain
HV352_RS12225	COG5001	Diguanylate cyclase
HV352_RS12230	COG3272	Protein of unknown function (DUF1722)
HV352_RS12235	COG0628	permease
HV352_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS12265	COG0583	DNA-binding transcription factor activity
HV352_RS12270	COG0477	Major facilitator Superfamily
HV352_RS12285	COG1942	4-Oxalocrotonate Tautomerase
HV352_RS12295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV352_RS12340	COG4977	sequence-specific DNA binding
HV352_RS12350	COG0386	Belongs to the glutathione peroxidase family
HV352_RS12385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV352_RS12400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV352_RS12410	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS12425	COG1113	amino acid transport
HV352_RS12435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV352_RS12445	COG0765	amino acid transport
HV352_RS12450	COG0765	amino acid transport
HV352_RS12460	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV352_RS12465	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS12475	COG2414	aldehyde ferredoxin oxidoreductase
HV352_RS12480	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS12515	COG1464	Belongs to the NlpA lipoprotein family
HV352_RS12520	COG2011	ABC-type metal ion transport system permease component
HV352_RS12540	COG1376	ErfK ybiS ycfS ynhG family protein
HV352_RS12555	COG0719	Fe-S assembly protein
HV352_RS12560	COG0396	ATPase activity
HV352_RS12565	COG0719	Fe-S assembly protein
HV352_RS12570	COG0316	Belongs to the HesB IscA family
HV352_RS12600	COG2050	protein possibly involved in aromatic compounds catabolism
HV352_RS12605	COG0247	lactate metabolic process
HV352_RS12605	COG0277	FAD linked oxidase domain protein
HV352_RS12610	COG0628	permease
HV352_RS12625	COG0738	Major facilitator superfamily
HV352_RS12630	COG2271	Major facilitator Superfamily
HV352_RS12645	COG4670	ketone body catabolic process
HV352_RS12650	COG1960	acyl-CoA dehydrogenase activity
HV352_RS12655	COG2207	Transcriptional regulator
HV352_RS12655	COG1917	Cupin 2, conserved barrel domain protein
HV352_RS12660	COG2086	electron transfer activity
HV352_RS12665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV352_RS12670	COG0644	oxidoreductase
HV352_RS12675	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV352_RS12680	COG0318	PFAM AMP-dependent synthetase and ligase
HV352_RS12685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV352_RS12685	COG0574	Belongs to the PEP-utilizing enzyme family
HV352_RS12695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV352_RS12700	COG4256	Hemin uptake protein
HV352_RS12705	COG4771	TonB-dependent receptor
HV352_RS12710	COG3720	iron ion transport
HV352_RS12715	COG4558	Periplasmic binding protein
HV352_RS12720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV352_RS12740	COG0791	NLP P60 protein
HV352_RS12750	COG0386	Belongs to the glutathione peroxidase family
HV352_RS12765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS12780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV352_RS12810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV352_RS12830	COG3137	Salt-induced outer membrane protein
HV352_RS12835	COG1105	Belongs to the carbohydrate kinase PfkB family
HV352_RS12840	COG3001	Fructosamine kinase
HV352_RS12850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV352_RS12860	COG1988	membrane-bound metal-dependent
HV352_RS12875	COG0753	catalase activity
HV352_RS12885	COG1486	melibiose metabolic process
HV352_RS12890	COG1917	Cupin 2, conserved barrel domain protein
HV352_RS12890	COG2169	Transcriptional regulator
HV352_RS12895	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV352_RS12900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV352_RS12905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV352_RS12910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV352_RS12920	COG0322	excinuclease ABC activity
HV352_RS12930	COG3678	ATP-independent chaperone mediated protein folding
HV352_RS12960	COG0708	Exodeoxyribonuclease III
HV352_RS12965	COG0398	Pfam SNARE associated Golgi protein
HV352_RS12970	COG0398	Pfam SNARE associated Golgi protein
HV352_RS12975	COG4134	Bacterial extracellular solute-binding protein
HV352_RS12980	COG4135	transport system, permease component
HV352_RS12985	COG4136	ATPase activity
HV352_RS12990	COG2897	thiosulfate sulfurtransferase activity
HV352_RS12995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV352_RS13000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV352_RS13005	COG0494	nUDIX hydrolase
HV352_RS13020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV352_RS13030	COG0778	Nitroreductase
HV352_RS13035	COG0616	signal peptide processing
HV352_RS13040	COG0252	asparaginase activity
HV352_RS13045	COG1335	isochorismatase
HV352_RS13050	COG2814	Major facilitator Superfamily
HV352_RS13055	COG1349	DNA-binding transcription factor activity
HV352_RS13060	COG0667	Aldo Keto reductase
HV352_RS13065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS13070	COG0191	fructose-bisphosphate aldolase activity
HV352_RS13075	COG1063	alcohol dehydrogenase
HV352_RS13080	COG2271	Major facilitator Superfamily
HV352_RS13085	COG1063	alcohol dehydrogenase
HV352_RS13100	COG3139	Protein of unknown function (DUF1315)
HV352_RS13120	COG0656	L-ascorbic acid biosynthetic process
HV352_RS13135	COG3713	MltA-interacting MipA family protein
HV352_RS13140	COG2766	serine protein kinase
HV352_RS13150	COG0110	maltose O-acetyltransferase activity
HV352_RS13160	COG2226	methyltransferase
HV352_RS13165	COG2199	diguanylate cyclase activity
HV352_RS13170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV352_RS13180	COG2207	Transcriptional regulator
HV352_RS13185	COG2807	transmembrane transport
HV352_RS13190	COG0504	CTP synthase activity
HV352_RS13195	COG3189	MarR family transcriptional regulator
HV352_RS13200	COG3042	response to heat
HV352_RS13205	COG2199	diguanylate cyclase activity
HV352_RS13205	COG2203	Gaf domain
HV352_RS13220	COG2261	transglycosylase associated protein
HV352_RS13225	COG3383	formate dehydrogenase (NAD+) activity
HV352_RS13240	COG3615	Tellurite resistance protein tehB
HV352_RS13250	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV352_RS13255	COG1124	(ABC) transporter
HV352_RS13265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV352_RS13270	COG0601	transmembrane transport
HV352_RS13275	COG0747	negative chemotaxis
HV352_RS13280	COG4771	TonB-dependent receptor
HV352_RS13300	COG1956	GAF domain-containing protein
HV352_RS13305	COG2995	paraquat-inducible protein a
HV352_RS13310	COG3008	intermembrane lipid transfer
HV352_RS13340	COG2135	peptidase activity
HV352_RS13345	COG3272	Protein of unknown function (DUF1722)
HV352_RS13365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV352_RS13380	COG0300	oxidoreductase activity
HV352_RS13390	COG0789	Transcriptional regulator
HV352_RS13400	COG3447	MASE1 domain protein
HV352_RS13400	COG5001	Diguanylate cyclase
HV352_RS13400	COG5002	protein histidine kinase activity
HV352_RS13410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV352_RS13485	COG1196	nuclear chromosome segregation
HV352_RS13580	COG3772	lysozyme
HV352_RS13625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV352_RS13635	COG1484	DNA-dependent DNA replication
HV352_RS13690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV352_RS13710	COG0582	viral genome integration into host DNA
HV352_RS13720	COG1276	copper resistance
HV352_RS13725	COG2372	response to copper ion
HV352_RS13735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV352_RS13740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV352_RS13745	COG1770	oligopeptidase
HV352_RS13750	COG2979	Protein of unknown function (DUF533)
HV352_RS13760	COG3141	response to X-ray
HV352_RS13770	COG0800	Aldolase
HV352_RS13775	COG0129	dihydroxy-acid dehydratase activity
HV352_RS13780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV352_RS13785	COG1737	Transcriptional regulator
HV352_RS13795	COG1560	Kdo2-lipid A biosynthetic process
HV352_RS13800	COG0739	heme binding
HV352_RS13805	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV352_RS13815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV352_RS13825	COG3111	PFAM Bacterial OB fold (BOF) protein
HV352_RS13835	COG2323	membrane
HV352_RS13840	COG1546	Belongs to the CinA family
HV352_RS13845	COG3685	Protein conserved in bacteria
HV352_RS13850	COG3685	Protein conserved in bacteria
HV352_RS13855	COG3729	General stress protein
HV352_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS13900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV352_RS13905	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV352_RS13980	COG0616	signal peptide processing
HV352_RS13995	COG1802	Transcriptional regulator
HV352_RS13995	COG4626	Terminase
HV352_RS14015	COG3038	cytochrome b561
HV352_RS14030	COG3772	lysozyme
HV352_RS14060	COG1403	HNH endonuclease
HV352_RS14150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV352_RS14160	COG0582	viral genome integration into host DNA
HV352_RS14175	COG2850	peptidyl-arginine hydroxylation
HV352_RS14200	COG3459	Glycosyltransferase 36 associated
HV352_RS14225	COG1289	transmembrane transporter activity
HV352_RS14235	COG1278	Cold shock
HV352_RS14250	COG1177	transmembrane transport
HV352_RS14260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV352_RS14270	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV352_RS14275	COG1136	(ABC) transporter
HV352_RS14280	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV352_RS14285	COG4763	Acyl-transferase
HV352_RS14290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV352_RS14295	COG1388	LysM domain
HV352_RS14295	COG1376	ErfK ybiS ycfS ynhG family protein
HV352_RS14305	COG1309	transcriptional regulator
HV352_RS14315	COG3134	Outer membrane lipoprotein
HV352_RS14320	COG1252	NADH dehydrogenase
HV352_RS14345	COG5633	Lipoprotein
HV352_RS14350	COG0537	adenosine 5'-monophosphoramidase activity
HV352_RS14355	COG4773	Receptor
HV352_RS14365	COG0534	Mate efflux family protein
HV352_RS14400	COG0583	DNA-binding transcription factor activity
HV352_RS14420	COG0477	Major facilitator Superfamily
HV352_RS14425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV352_RS14430	COG0006	proline dipeptidase activity
HV352_RS14440	COG0084	hydrolase, TatD family'
HV352_RS14445	COG0470	DNA polymerase III
HV352_RS14455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV352_RS14460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV352_RS14465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV352_RS14500	COG1399	metal-binding, possibly nucleic acid-binding protein
HV352_RS14510	COG0564	pseudouridine synthase activity
HV352_RS14515	COG1530	ribonuclease E activity
HV352_RS14545	COG4786	Flagellar basal body rod
HV352_RS14550	COG4787	bacterial-type flagellum-dependent cell motility
HV352_RS14565	COG1558	bacterial-type flagellum-dependent cell motility
HV352_RS14605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV352_RS14645	COG3038	cytochrome b561
HV352_RS14660	COG1560	Kdo2-lipid A biosynthetic process
HV352_RS14675	COG5645	(Lipo)protein
HV352_RS14695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV352_RS14750	COG3381	protein complex oligomerization
HV352_RS14775	COG1702	phosphate starvation-inducible protein PhoH
HV352_RS14795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV352_RS14800	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV352_RS14800	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV352_RS14800	COG0506	proline dehydrogenase activity
HV352_RS14805	COG3755	Protein conserved in bacteria
HV352_RS14810	COG1309	transcriptional regulator
HV352_RS14820	COG3729	General stress protein
HV352_RS14840	COG0640	Transcriptional regulator
HV352_RS14850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV352_RS14855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV352_RS14855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV352_RS14905	COG0813	purine-nucleoside phosphorylase activity
HV352_RS14925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV352_RS14930	COG1120	ATPase activity
HV352_RS14945	COG2857	Cytochrome c1
HV352_RS14945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV352_RS14960	COG4166	transmembrane transport
HV352_RS14965	COG0670	Belongs to the BI1 family
HV352_RS15005	COG2920	part of a sulfur-relay system
HV352_RS15025	COG1832	CoA-binding protein
HV352_RS15040	COG0210	DNA helicase
HV352_RS15045	COG3304	Inner membrane component domain
HV352_RS15050	COG1289	transmembrane transporter activity
HV352_RS15055	COG3070	regulator of competence-specific genes
HV352_RS15075	COG1067	ATP-dependent peptidase activity
HV352_RS15085	COG3130	regulation of translation
HV352_RS15090	COG3009	Protein conserved in bacteria
HV352_RS15095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV352_RS15095	COG3008	intermembrane lipid transfer
HV352_RS15100	COG2995	paraquat-inducible protein a
HV352_RS15105	COG0488	(ABC) transporter
HV352_RS15115	COG3217	Mosc domain protein beta barrel domain protein
HV352_RS15115	COG0633	Ferredoxin
HV352_RS15130	COG0431	NADPH-dependent FMN reductase
HV352_RS15135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV352_RS15145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV352_RS15155	COG0308	aminopeptidase N
HV352_RS15175	COG1448	Aminotransferase
HV352_RS15180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV352_RS15185	COG3108	Peptidase M15
HV352_RS15190	COG2989	Protein conserved in bacteria
HV352_RS15200	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV352_RS15210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV352_RS15215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV352_RS15220	COG3173	Aminoglycoside phosphotransferase
HV352_RS15235	COG3214	Protein conserved in bacteria
HV352_RS15250	COG2333	competence protein COMEC
HV352_RS15250	COG0658	competence protein
HV352_RS15255	COG0776	regulation of translation
HV352_RS15260	COG0539	negative regulation of cytoplasmic translation
HV352_RS15280	COG2323	membrane
HV352_RS15285	COG1944	ATP diphosphatase activity
HV352_RS15290	COG2116	formate transmembrane transporter activity
HV352_RS15295	COG1882	Formate acetyltransferase
HV352_RS15300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV352_RS15320	COG3959	Transketolase, thiamine diphosphate binding domain
HV352_RS15325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV352_RS15330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS15340	COG1335	isochorismatase
HV352_RS15345	COG3302	dmso reductase anchor subunit
HV352_RS15350	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS15355	COG0243	molybdopterin cofactor binding
HV352_RS15365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV352_RS15385	COG0492	ferredoxin-NADP+ reductase activity
HV352_RS15390	COG4988	ABC transporter
HV352_RS15395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV352_RS15410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV352_RS15415	COG0583	DNA-binding transcription factor activity
HV352_RS15425	COG1335	isochorismatase
HV352_RS15435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV352_RS15445	COG1177	transmembrane transport
HV352_RS15450	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV352_RS15455	COG3842	ATPase activity
HV352_RS15460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV352_RS15520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV352_RS15525	COG5301	cellulose 1,4-beta-cellobiosidase activity
HV352_RS15615	COG4695	Portal protein
HV352_RS15690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV352_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS15700	COG3226	Transcriptional regulator
HV352_RS15705	COG0738	Major facilitator superfamily
HV352_RS15710	COG0561	phosphatase activity
HV352_RS15720	COG2814	Major facilitator Superfamily
HV352_RS15725	COG0671	phosphoesterase, PA-phosphatase related
HV352_RS15730	COG1349	DNA-binding transcription factor activity
HV352_RS15735	COG1686	Belongs to the peptidase S11 family
HV352_RS15740	COG0625	glutathione transferase activity
HV352_RS15745	COG2133	pyrroloquinoline quinone binding
HV352_RS15780	COG1446	asparaginase
HV352_RS15790	COG0303	'Molybdopterin
HV352_RS15795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV352_RS15800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV352_RS15805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV352_RS15810	COG1882	Formate acetyltransferase
HV352_RS15815	COG0561	phosphatase activity
HV352_RS15825	COG0488	(ABC) transporter
HV352_RS15830	COG1376	ErfK ybiS ycfS ynhG family protein
HV352_RS15835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV352_RS15850	COG2194	sulfuric ester hydrolase activity
HV352_RS15855	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV352_RS15870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV352_RS15875	COG0765	amino acid transport
HV352_RS15880	COG1126	abc transporter atp-binding protein
HV352_RS15885	COG0668	transmembrane transport
HV352_RS15900	COG4774	siderophore transport
HV352_RS15910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV352_RS15920	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV352_RS15925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV352_RS15935	COG0513	Belongs to the DEAD box helicase family
HV352_RS15940	COG1309	transcriptional regulator
HV352_RS15950	COG1131	(ABC) transporter
HV352_RS15955	COG0842	Transport permease protein
HV352_RS15960	COG0842	Transport permease protein
HV352_RS15970	COG3568	Endonuclease Exonuclease Phosphatase
HV352_RS15975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV352_RS15980	COG0392	lysyltransferase activity
HV352_RS15985	COG0670	Belongs to the BI1 family
HV352_RS15990	COG0314	molybdopterin synthase activity
HV352_RS15995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV352_RS16005	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV352_RS16020	COG1757	Na H antiporter
HV352_RS16025	COG0626	cystathionine gamma-synthase activity
HV352_RS16040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV352_RS16080	COG1881	PFAM PEBP family protein
HV352_RS16110	COG4677	pectinesterase activity
HV352_RS16115	COG2165	general secretion pathway protein
HV352_RS16130	COG4796	Type ii and iii secretion system protein
HV352_RS16150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV352_RS16155	COG1459	type II secretion system
HV352_RS16160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HV352_RS16165	COG0741	lytic transglycosylase activity
HV352_RS16165	COG0739	heme binding
HV352_RS16165	COG1196	nuclear chromosome segregation
HV352_RS16180	COG0561	phosphatase activity
HV352_RS16190	COG4149	molybdate abc transporter
HV352_RS16195	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV352_RS16205	COG2005	Transcriptional regulator
HV352_RS16205	COG3585	molybdate ion transport
HV352_RS16210	COG1119	ATPase activity
HV352_RS16215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV352_RS16220	COG1085	galactose-1-phosphate uridylyltransferase
HV352_RS16230	COG2017	converts alpha-aldose to the beta-anomer
HV352_RS16240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV352_RS16250	COG1230	cation diffusion facilitator family transporter
HV352_RS16255	COG3201	nicotinamide mononucleotide transporter
HV352_RS16295	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV352_RS16300	COG2885	chlorophyll binding
HV352_RS16310	COG3064	Membrane
HV352_RS16315	COG0848	biopolymer transport protein
HV352_RS16320	COG0811	peptide transport
HV352_RS16325	COG0824	Thioesterase
HV352_RS16330	COG3790	cyd operon protein YbgE
HV352_RS16335	COG4890	Cyd operon protein YbgT
HV352_RS16340	COG1294	oxidase, subunit
HV352_RS16345	COG1271	oxidase subunit
HV352_RS16350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV352_RS16360	COG4865	methylaspartate mutase activity
HV352_RS16365	COG3799	methylaspartate ammonia-lyase activity
HV352_RS16380	COG1301	dicarboxylic acid transport
HV352_RS16390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS16390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS16400	COG0583	DNA-binding transcription factor activity
HV352_RS16405	COG1648	precorrin-2 dehydrogenase activity
HV352_RS16405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV352_RS16415	COG3395	kinase activity
HV352_RS16420	COG0235	Class ii aldolase
HV352_RS16425	COG1349	DNA-binding transcription factor activity
HV352_RS16430	COG3622	Belongs to the hyi family
HV352_RS16435	COG3246	L-lysine catabolic process to acetate
HV352_RS16455	COG0383	alpha-mannosidase activity
HV352_RS16460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS16460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS16460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS16465	COG2188	Transcriptional regulator
HV352_RS16470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV352_RS16480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV352_RS16485	COG0567	Dehydrogenase, E1 component
HV352_RS16490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV352_RS16495	COG1053	succinate dehydrogenase
HV352_RS16500	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV352_RS16505	COG2009	succinate dehydrogenase
HV352_RS16515	COG3180	Ammonia monooxygenase
HV352_RS16545	COG1984	allophanate hydrolase subunit 2
HV352_RS16550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV352_RS16565	COG5464	transposase or invertase
HV352_RS16600	COG2205	protein histidine kinase activity
HV352_RS16605	COG0745	RESPONSE REGULATOR receiver
HV352_RS16615	COG1982	Orn Lys Arg decarboxylase major
HV352_RS16620	COG0531	amino acid
HV352_RS16625	COG0033	Phosphoglucomutase
HV352_RS16630	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV352_RS16635	COG0596	Alpha beta hydrolase
HV352_RS16645	COG0716	FMN binding
HV352_RS16655	COG0735	belongs to the Fur family
HV352_RS16660	COG0583	DNA-binding transcription factor activity
HV352_RS16665	COG1053	succinate dehydrogenase
HV352_RS16690	COG1609	Transcriptional regulator
HV352_RS16700	COG1653	transport
HV352_RS16710	COG2190	(PTS) system
HV352_RS16710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS16710	COG1263	PTS System
HV352_RS16720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV352_RS16725	COG1940	carbohydrate kinase activity
HV352_RS16725	COG1846	Transcriptional regulator
HV352_RS16730	COG0647	UMP catabolic process
HV352_RS16735	COG0367	asparagine synthase
HV352_RS16775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV352_RS16785	COG1702	phosphate starvation-inducible protein PhoH
HV352_RS16790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV352_RS16810	COG0765	amino acid transport
HV352_RS16815	COG0765	amino acid transport
HV352_RS16820	COG1126	abc transporter atp-binding protein
HV352_RS16830	COG2888	peptidyl-tyrosine sulfation
HV352_RS16845	COG1466	dna polymerase III delta subunit
HV352_RS16865	COG0799	negative regulation of ribosome biogenesis
HV352_RS16875	COG0768	penicillin binding
HV352_RS16880	COG0772	Belongs to the SEDS family
HV352_RS16885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV352_RS16890	COG1686	Belongs to the peptidase S11 family
HV352_RS16915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV352_RS16935	COG3069	C4-dicarboxylate transmembrane transporter activity
HV352_RS16940	COG4565	transcriptional regulatory protein
HV352_RS16945	COG3290	protein histidine kinase activity
HV352_RS16950	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV352_RS16960	COG2301	Belongs to the HpcH HpaI aldolase family
HV352_RS16965	COG3051	citrate lyase alpha subunit
HV352_RS16980	COG0471	metal ion transport
HV352_RS16985	COG3719	Belongs to the RNase T2 family
HV352_RS17000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV352_RS17030	COG3634	alkyl hydroperoxide reductase activity
HV352_RS17040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV352_RS17045	COG0583	DNA-binding transcription factor activity
HV352_RS17050	COG3969	phosphoadenosine phosphosulfate
HV352_RS17055	COG1475	DNA binding
HV352_RS17060	COG0436	Aminotransferase
HV352_RS17065	COG0371	Dehydrogenase
HV352_RS17070	COG2879	small protein
HV352_RS17075	COG1966	Carbon starvation protein
HV352_RS17085	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS17090	COG1535	isochorismatase
HV352_RS17090	COG3433	isochorismatase activity
HV352_RS17095	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV352_RS17100	COG1169	isochorismate synthase
HV352_RS17105	COG4592	Periplasmic binding protein
HV352_RS17115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV352_RS17120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV352_RS17125	COG1120	ATPase activity
HV352_RS17130	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV352_RS17130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV352_RS17135	COG3251	PFAM MbtH domain protein
HV352_RS17140	COG2382	esterase
HV352_RS17145	COG4771	TonB-dependent receptor
HV352_RS17155	COG1879	ABC-type sugar transport system periplasmic component
HV352_RS17165	COG1129	ABC transporter
HV352_RS17170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS17175	COG2390	Transcriptional regulator
HV352_RS17180	COG3959	Transketolase, thiamine diphosphate binding domain
HV352_RS17185	COG3958	Transketolase
HV352_RS17195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV352_RS17230	COG2315	Protein conserved in bacteria
HV352_RS17240	COG0668	transmembrane transport
HV352_RS17260	COG2211	Major facilitator Superfamily
HV352_RS17265	COG1113	amino acid transport
HV352_RS17285	COG3300	MHYT domain
HV352_RS17285	COG5001	Diguanylate cyclase
HV352_RS17300	COG3059	membrane
HV352_RS17310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV352_RS17315	COG2207	Transcriptional regulator
HV352_RS17320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV352_RS17325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS17330	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS17335	COG1538	Outer membrane efflux protein
HV352_RS17340	COG0745	RESPONSE REGULATOR receiver
HV352_RS17345	COG5002	protein histidine kinase activity
HV352_RS17365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV352_RS17365	COG0321	lipoyl(octanoyl) transferase activity
HV352_RS17370	COG0243	molybdopterin cofactor binding
HV352_RS17375	COG3005	denitrification pathway
HV352_RS17395	COG3005	denitrification pathway
HV352_RS17400	COG0745	RESPONSE REGULATOR receiver
HV352_RS17405	COG1879	ABC-type sugar transport system periplasmic component
HV352_RS17410	COG2198	Histidine kinase
HV352_RS17410	COG0784	Response regulator, receiver
HV352_RS17410	COG2205	protein histidine kinase activity
HV352_RS17475	COG2501	S4 domain
HV352_RS17480	COG1988	membrane-bound metal-dependent
HV352_RS17490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV352_RS17500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV352_RS17505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV352_RS17515	COG2011	ABC-type metal ion transport system permease component
HV352_RS17525	COG1464	Belongs to the NlpA lipoprotein family
HV352_RS17535	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV352_RS17540	COG4181	ATPase activity
HV352_RS17545	COG2755	lipolytic protein G-D-S-L family
HV352_RS17550	COG0300	oxidoreductase activity
HV352_RS17555	COG3118	belongs to the thioredoxin family
HV352_RS17560	COG0390	transport system, permease component
HV352_RS17565	COG4619	ABC transporter
HV352_RS17570	COG0330	HflC and HflK could
HV352_RS17575	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV352_RS17595	COG4771	TonB-dependent receptor
HV352_RS17600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV352_RS17610	COG3721	Heme iron utilization protein
HV352_RS17620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV352_RS17635	COG3735	TraB family
HV352_RS17640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV352_RS17650	COG2223	nitrite transmembrane transporter activity
HV352_RS17655	COG4651	solute:proton antiporter activity
HV352_RS17655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV352_RS17660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS17705	COG2832	Protein of unknown function (DUF454)
HV352_RS17710	COG3923	Primosomal replication protein n
HV352_RS17720	COG1196	nuclear chromosome segregation
HV352_RS17720	COG3264	Mechanosensitive ion channel
HV352_RS17725	COG1309	transcriptional regulator
HV352_RS17730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV352_RS17735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV352_RS17750	COG0110	maltose O-acetyltransferase activity
HV352_RS17770	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV352_RS17775	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV352_RS17780	COG2364	Membrane
HV352_RS17785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV352_RS17805	COG3695	enzyme binding
HV352_RS17810	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV352_RS17815	COG1946	Acyl-CoA thioesterase
HV352_RS17820	COG0004	ammonium transporteR
HV352_RS17825	COG0347	Belongs to the P(II) protein family
HV352_RS17830	COG1132	(ABC) transporter
HV352_RS17835	COG1132	(ABC) transporter
HV352_RS17840	COG1522	sequence-specific DNA binding
HV352_RS17855	COG4533	DNA binding
HV352_RS17865	COG0824	Thioesterase
HV352_RS17870	COG1555	photosystem II stabilization
HV352_RS17875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV352_RS17880	COG0776	regulation of translation
HV352_RS17885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV352_RS17905	COG0271	Belongs to the BolA IbaG family
HV352_RS17910	COG3056	Lipoprotein
HV352_RS17915	COG2223	nitrite transmembrane transporter activity
HV352_RS17920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV352_RS17925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV352_RS17930	COG1845	cytochrome c oxidase, subunit III
HV352_RS17935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV352_RS17960	COG2814	Major facilitator Superfamily
HV352_RS17995	COG0142	geranyltranstransferase activity
HV352_RS18005	COG0667	Aldo Keto reductase
HV352_RS18010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV352_RS18015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV352_RS18030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV352_RS18030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV352_RS18040	COG4238	major outer membrane lipoprotein
HV352_RS18045	COG3248	Nucleoside-binding outer membrane protein
HV352_RS18060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV352_RS18065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV352_RS18070	COG1862	Preprotein translocase
HV352_RS18080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV352_RS18090	COG0450	alkyl hydroperoxide reductase
HV352_RS18105	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV352_RS18115	COG1335	isochorismatase
HV352_RS18120	COG0583	DNA-binding transcription factor activity
HV352_RS18125	COG0366	Alpha amylase catalytic
HV352_RS18140	COG5002	protein histidine kinase activity
HV352_RS18150	COG0420	3'-5' exonuclease activity
HV352_RS18155	COG0419	ATPase involved in DNA repair
HV352_RS18165	COG1940	carbohydrate kinase activity
HV352_RS18180	COG4126	flavin adenine dinucleotide binding
HV352_RS18200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV352_RS18205	COG3706	GGDEF domain
HV352_RS18215	COG1785	Belongs to the alkaline phosphatase family
HV352_RS18230	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV352_RS18250	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV352_RS18255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV352_RS18260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV352_RS18270	COG0113	porphobilinogen synthase activity
HV352_RS18275	COG2175	clavaminate synthase activity
HV352_RS18280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV352_RS18285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV352_RS18290	COG4521	taurine ABC transporter
HV352_RS18305	COG2271	Major facilitator Superfamily
HV352_RS18310	COG1840	ABC-type Fe3 transport system, periplasmic component
HV352_RS18320	COG3842	ATPase activity
HV352_RS18325	COG2040	homocysteine
HV352_RS18330	COG0833	amino acid
HV352_RS18335	COG2814	Major facilitator Superfamily
HV352_RS18370	COG1414	Transcriptional regulator
HV352_RS18420	COG3210	domain, Protein
HV352_RS18435	COG1609	Transcriptional regulator
HV352_RS18460	COG2079	MmgE PrpD family protein
HV352_RS18465	COG0372	Belongs to the citrate synthase family
HV352_RS18475	COG3829	transcription factor binding
HV352_RS18485	COG1280	lysine exporter protein (LysE YggA)
HV352_RS18490	COG3706	GGDEF domain
HV352_RS18495	COG0348	domain, Protein
HV352_RS18515	COG0840	transmembrane signaling receptor activity
HV352_RS18530	COG3069	C4-dicarboxylate transmembrane transporter activity
HV352_RS18535	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV352_RS18545	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV352_RS18550	COG0693	protein deglycase activity
HV352_RS18555	COG0531	amino acid
HV352_RS18560	COG0174	glutamine synthetase
HV352_RS18565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV352_RS18570	COG1396	sequence-specific DNA binding
HV352_RS18570	COG1917	Cupin 2, conserved barrel domain protein
HV352_RS18575	COG1012	belongs to the aldehyde dehydrogenase family
HV352_RS18580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV352_RS18595	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HV352_RS18600	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV352_RS18605	COG1999	signal sequence binding
HV352_RS18610	COG1773	rubredoxin
HV352_RS18615	COG1271	oxidase subunit
HV352_RS18620	COG1294	oxidase, subunit
HV352_RS18695	COG0582	viral genome integration into host DNA
HV352_RS18710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV352_RS18750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV352_RS18760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV352_RS18785	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV352_RS18810	COG0791	NLP P60 protein
HV352_RS18815	COG3034	peptidoglycan biosynthetic process
HV352_RS18820	COG0121	glutamine amidotransferase
HV352_RS18830	COG1960	acyl-CoA dehydrogenase activity
HV352_RS18835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV352_RS18845	COG2200	EAL domain
HV352_RS18860	COG3539	Fimbrial protein
HV352_RS18870	COG3121	Chaperone
HV352_RS18875	COG3188	usher protein
HV352_RS18885	COG3539	Fimbrial protein
HV352_RS18905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV352_RS18915	COG2226	methyltransferase
HV352_RS18925	COG0741	lytic transglycosylase activity
HV352_RS18925	COG1388	LysM domain
HV352_RS18930	COG2226	methyltransferase
HV352_RS18940	COG2814	Major facilitator Superfamily
HV352_RS18945	COG0583	DNA-binding transcription factor activity
HV352_RS18980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV352_RS18990	COG2011	ABC-type metal ion transport system permease component
HV352_RS18995	COG1464	Belongs to the NlpA lipoprotein family
HV352_RS19005	COG1720	tRNA m6t6A37 methyltransferase activity
HV352_RS19015	COG0791	NLP P60 protein
HV352_RS19020	COG3015	lipoprotein NlpE involved in copper resistance
HV352_RS19025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV352_RS19040	COG4568	rho-dependent transcription termination
HV352_RS19050	COG0346	lactoylglutathione lyase activity
HV352_RS19090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV352_RS19095	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV352_RS19110	COG0575	Belongs to the CDS family
HV352_RS19120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV352_RS19165	COG3835	regulator
HV352_RS19190	COG2860	membrane
HV352_RS19215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV352_RS19220	COG1120	ATPase activity
HV352_RS19225	COG4774	siderophore transport
HV352_RS19230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV352_RS19235	COG1643	Atp-dependent helicase
HV352_RS19240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV352_RS19260	COG0617	tRNA 3'-terminal CCA addition
HV352_RS19265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV352_RS19285	COG0726	polysaccharide deacetylase
HV352_RS19290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS19295	COG0842	Transport permease protein
HV352_RS19300	COG1131	(ABC) transporter
HV352_RS19305	COG0288	reversible hydration of carbon dioxide
HV352_RS19310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV352_RS19315	COG4993	Dehydrogenase
HV352_RS19335	COG1609	Transcriptional regulator
HV352_RS19340	COG2814	Major facilitator Superfamily
HV352_RS19360	COG3064	Membrane
HV352_RS19375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV352_RS19380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV352_RS19385	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV352_RS19400	COG2211	Major facilitator Superfamily
HV352_RS19405	COG3940	Belongs to the glycosyl hydrolase 43 family
HV352_RS19410	COG3725	Membrane protein required for beta-lactamase induction
HV352_RS19425	COG4969	Belongs to the N-Me-Phe pilin family
HV352_RS19430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV352_RS19435	COG1459	type II secretion system
HV352_RS19445	COG0237	dephospho-CoA kinase activity
HV352_RS19460	COG0494	nUDIX hydrolase
HV352_RS19480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV352_RS19485	COG0849	cell division
HV352_RS19495	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV352_RS19510	COG0772	Belongs to the SEDS family
HV352_RS19515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV352_RS19525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV352_RS19530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV352_RS19535	COG0768	penicillin binding
HV352_RS19565	COG0028	Belongs to the TPP enzyme family
HV352_RS19600	COG2814	Major facilitator Superfamily
HV352_RS19620	COG1178	ABC-type Fe3 transport system permease component
HV352_RS19630	COG0586	Pfam SNARE associated Golgi protein
HV352_RS19650	COG0235	Class ii aldolase
HV352_RS19660	COG0417	DNA replication proofreading
HV352_RS19670	COG0564	pseudouridine synthase activity
HV352_RS19730	COG2271	Major facilitator Superfamily
HV352_RS19740	COG0644	oxidoreductase
HV352_RS19790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV352_RS19795	COG0505	Belongs to the CarA family
HV352_RS19805	COG1609	Transcriptional regulator
HV352_RS19820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS19820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS19825	COG3715	PTS system
HV352_RS19830	COG3716	PTS system mannose fructose sorbose family IID component
HV352_RS19840	COG2140	Oxalate decarboxylase
HV352_RS19855	COG1047	Peptidyl-prolyl cis-trans
HV352_RS19870	COG0196	riboflavin kinase activity
HV352_RS19895	COG0583	DNA-binding transcription factor activity
HV352_RS19910	COG0443	Heat shock 70 kDa protein
HV352_RS19915	COG1584	GPR1 FUN34 yaaH family protein
HV352_RS19925	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV352_RS19935	COG1115	amino acid carrier protein
HV352_RS19945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV352_RS19955	COG0460	homoserine dehydrogenase
HV352_RS19955	COG0527	aspartate kinase activity
HV352_RS19965	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV352_RS19975	COG0745	RESPONSE REGULATOR receiver
HV352_RS19980	COG4452	Inner membrane protein CreD
HV352_RS19985	COG2205	protein histidine kinase activity
HV352_RS19990	COG0745	RESPONSE REGULATOR receiver
HV352_RS19995	COG3045	CreA protein
HV352_RS20000	COG2207	Transcriptional regulator
HV352_RS20000	COG3708	Transcriptional regulator
HV352_RS20020	COG0741	lytic transglycosylase activity
HV352_RS20025	COG0488	(ABC) transporter
HV352_RS20040	COG0560	Phosphoserine phosphatase
HV352_RS20045	COG3726	membrane protein affecting hemolysin expression
HV352_RS20075	COG1328	CTP reductase activity
HV352_RS20080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV352_RS20085	COG0084	hydrolase, TatD family'
HV352_RS20090	COG4667	esterase of the alpha-beta hydrolase superfamily
HV352_RS20095	COG5487	UPF0391 membrane protein
HV352_RS20100	COG2823	Periplasmic or secreted lipoprotein
HV352_RS20110	COG1011	Hydrolase
HV352_RS20115	COG0456	acetyltransferase
HV352_RS20120	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV352_RS20150	COG3706	GGDEF domain
HV352_RS20155	COG4114	ferric iron reductase
HV352_RS20160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV352_RS20165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV352_RS20170	COG2197	response regulator
HV352_RS20175	COG2197	response regulator
HV352_RS20180	COG2966	Psort location CytoplasmicMembrane, score
HV352_RS20195	COG1484	DNA-dependent DNA replication
HV352_RS20215	COG1063	alcohol dehydrogenase
HV352_RS20220	COG1802	Transcriptional regulator
HV352_RS20225	COG2271	Major facilitator Superfamily
HV352_RS20235	COG0840	transmembrane signaling receptor activity
HV352_RS20245	COG1966	Carbon starvation protein
HV352_RS20250	COG2879	small protein
HV352_RS20255	COG0523	cobalamin synthesis protein
HV352_RS20300	COG5457	Domain of unknown function (DUF1127)
HV352_RS20305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV352_RS20310	COG5464	transposase or invertase
HV352_RS20315	COG2207	Transcriptional regulator
HV352_RS20315	COG1917	Cupin 2, conserved barrel domain protein
HV352_RS20330	COG0626	cystathionine gamma-synthase activity
HV352_RS20335	COG1301	dicarboxylic acid transport
HV352_RS20340	COG0583	DNA-binding transcription factor activity
HV352_RS20345	COG2733	membrane
HV352_RS20350	COG0477	Major facilitator Superfamily
HV352_RS20360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV352_RS20370	COG2186	Transcriptional regulator
HV352_RS20375	COG0246	Mannitol dehydrogenase
HV352_RS20385	COG2610	gluconate transmembrane transporter activity
HV352_RS20390	COG1556	Lactate utilization protein
HV352_RS20395	COG1139	Iron-sulfur cluster binding protein
HV352_RS20400	COG0247	lactate metabolic process
HV352_RS20405	COG1620	l-lactate permease
HV352_RS20470	COG2003	Belongs to the UPF0758 family
HV352_RS20535	COG4195	phage-related replication protein
HV352_RS20540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HV352_RS20560	COG0582	viral genome integration into host DNA
HV352_RS20570	COG1064	alcohol dehydrogenase
HV352_RS20575	COG3265	gluconokinase activity
HV352_RS20580	COG1063	alcohol dehydrogenase
HV352_RS20585	COG1028	Short-chain dehydrogenase reductase Sdr
HV352_RS20590	COG2610	gluconate transmembrane transporter activity
HV352_RS20595	COG1609	Transcriptional regulator
HV352_RS20600	COG0433	COG0433 Predicted ATPase
HV352_RS20605	COG0795	lipopolysaccharide-transporting ATPase activity
HV352_RS20610	COG0795	lipopolysaccharide-transporting ATPase activity
HV352_RS20620	COG2927	DNA polymerase III (CHI subunit)
HV352_RS20625	COG0525	valine-tRNA ligase activity
HV352_RS20655	COG2731	YhcH YjgK YiaL family protein
HV352_RS20670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV352_RS20675	COG1288	antiporter activity
HV352_RS20680	COG1438	arginine binding
HV352_RS20725	COG1609	Transcriptional regulator
HV352_RS20730	COG1263	PTS System
HV352_RS20730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV352_RS20735	COG0366	Alpha amylase catalytic
HV352_RS20755	COG3501	Rhs element vgr protein
HV352_RS20760	COG2026	Addiction module toxin, RelE StbE family
HV352_RS20840	COG3711	transcriptional antiterminator
HV352_RS20840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS20855	COG3964	amidohydrolase
HV352_RS20890	COG0312	modulator of DNA gyrase
HV352_RS20900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV352_RS20905	COG0363	glucosamine-6-phosphate deaminase activity
HV352_RS20910	COG1486	melibiose metabolic process
HV352_RS20915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV352_RS20915	COG0517	IMP dehydrogenase activity
HV352_RS20920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV352_RS20930	COG0840	transmembrane signaling receptor activity
HV352_RS20935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS20940	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS20945	COG1129	ABC transporter
HV352_RS20950	COG1879	ABC-type sugar transport system periplasmic component
HV352_RS20960	COG3391	amine dehydrogenase activity
HV352_RS20965	COG4771	TonB-dependent receptor
HV352_RS20970	COG2105	PFAM AIG2 family protein
HV352_RS20975	COG2911	Protein conserved in bacteria
HV352_RS20980	COG0729	surface antigen
HV352_RS20990	COG1253	flavin adenine dinucleotide binding
HV352_RS21000	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV352_RS21005	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV352_RS21015	COG1733	regulation of RNA biosynthetic process
HV352_RS21020	COG0702	epimerase
HV352_RS21030	COG0697	spore germination
HV352_RS21035	COG0840	transmembrane signaling receptor activity
HV352_RS21045	COG1113	amino acid transport
HV352_RS21050	COG0545	Peptidyl-prolyl cis-trans isomerase
HV352_RS21055	COG3061	Opacity-associated protein A
HV352_RS21070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV352_RS21085	COG0730	response to heat
HV352_RS21135	COG1073	alpha beta
HV352_RS21140	COG3650	response to hydrogen peroxide
HV352_RS21150	COG1960	acyl-CoA dehydrogenase activity
HV352_RS21155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV352_RS21160	COG0557	exoribonuclease II activity
HV352_RS21175	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV352_RS21180	COG0330	HflC and HflK could
HV352_RS21185	COG0330	HflC and HflK could
HV352_RS21190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV352_RS21195	COG1923	regulation of RNA biosynthetic process
HV352_RS21210	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV352_RS21215	COG0802	atpase or kinase
HV352_RS21220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV352_RS21220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV352_RS21225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV352_RS21260	COG1511	domain protein
HV352_RS21260	COG3264	Mechanosensitive ion channel
HV352_RS21285	COG1053	succinate dehydrogenase
HV352_RS21290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV352_RS21345	COG1509	lysine 2,3-aminomutase activity
HV352_RS21370	COG0531	amino acid
HV352_RS21375	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV352_RS21380	COG1027	Aspartate ammonia-lyase
HV352_RS21385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV352_RS21400	COG1309	transcriptional regulator
HV352_RS21430	COG3290	protein histidine kinase activity
HV352_RS21435	COG4565	transcriptional regulatory protein
HV352_RS21445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV352_RS21450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS21450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV352_RS21455	COG3647	Membrane
HV352_RS21465	COG2211	Major facilitator Superfamily
HV352_RS21470	COG1486	melibiose metabolic process
HV352_RS21475	COG2169	Transcriptional regulator
HV352_RS21480	COG1982	Orn Lys Arg decarboxylase major
HV352_RS21485	COG2207	Transcriptional regulator
HV352_RS21490	COG0531	amino acid
HV352_RS21535	COG2824	Alkylphosphonate utilization operon protein PhnA
HV352_RS21540	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV352_RS21545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV352_RS21550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV352_RS21555	COG3639	organic phosphonate transmembrane transporter activity
HV352_RS21560	COG2188	Transcriptional regulator
HV352_RS21565	COG3624	Phosphonate C-P lyase system protein PhnG
HV352_RS21570	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV352_RS21575	COG3626	phosphonate metabolism
HV352_RS21580	COG3627	carbon phosphorus lyase activity
HV352_RS21585	COG4107	phosphonate C-P lyase system protein PhnK
HV352_RS21590	COG4778	phosphonate C-P lyase system protein PhnL
HV352_RS21595	COG3454	Phosphonate metabolism
HV352_RS21600	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV352_RS21605	COG0456	acetyltransferase
HV352_RS21610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV352_RS21625	COG1129	ABC transporter
HV352_RS21630	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS21685	COG0745	RESPONSE REGULATOR receiver
HV352_RS21695	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV352_RS21700	COG1301	dicarboxylic acid transport
HV352_RS21705	COG4235	cytochrome complex assembly
HV352_RS21710	COG3088	subunit of a heme lyase
HV352_RS21715	COG1138	Cytochrome C-type biogenesis protein
HV352_RS21720	COG3301	Polysulphide reductase, NrfD
HV352_RS21725	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS21730	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV352_RS21745	COG3162	membrane
HV352_RS21755	COG1346	cytolysis
HV352_RS21760	COG1380	Effector of murein hydrolase LrgA
HV352_RS21765	COG0583	DNA-binding transcription factor activity
HV352_RS21770	COG0025	NhaP-type Na H and K H
HV352_RS21775	COG2252	PERMEase
HV352_RS21780	COG0789	Transcriptional regulator
HV352_RS21790	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV352_RS21800	COG0629	single-stranded DNA binding
HV352_RS21805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV352_RS21810	COG2315	Protein conserved in bacteria
HV352_RS21815	COG3700	Belongs to the class B bacterial acid phosphatase family
HV352_RS21820	COG1448	Aminotransferase
HV352_RS21830	COG0305	Participates in initiation and elongation during chromosome replication
HV352_RS21845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV352_RS21855	COG0735	belongs to the Fur family
HV352_RS21860	COG3237	CsbD-like
HV352_RS21865	COG0534	Mate efflux family protein
HV352_RS21875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV352_RS21910	COG2182	Extracellular solute-binding protein
HV352_RS21925	COG3223	Belongs to the PsiE family
HV352_RS21930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV352_RS21935	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV352_RS21960	COG0527	aspartate kinase activity
HV352_RS21975	COG1187	pseudouridine synthase activity
HV352_RS21980	COG4977	sequence-specific DNA binding
HV352_RS22000	COG1410	methionine synthase
HV352_RS22000	COG0646	methionine synthase
HV352_RS22020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV352_RS22050	COG0151	Belongs to the GarS family
HV352_RS22060	COG4191	Histidine kinase
HV352_RS22115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV352_RS22120	COG2104	thiamine diphosphate biosynthetic process
HV352_RS22135	COG1278	Cold shock
HV352_RS22145	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV352_RS22180	COG0250	Participates in transcription elongation, termination and antitermination
HV352_RS22225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV352_RS22285	COG0583	DNA-binding transcription factor activity
HV352_RS22290	COG3979	chitinase
HV352_RS22325	COG2207	Transcriptional regulator
HV352_RS22330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS22335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV352_RS22340	COG1882	Formate acetyltransferase
HV352_RS22345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS22350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS22355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS22355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS22355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV352_RS22365	COG0371	Dehydrogenase
HV352_RS22375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV352_RS22380	COG0583	DNA-binding transcription factor activity
HV352_RS22390	COG0737	Belongs to the 5'-nucleotidase family
HV352_RS22400	COG0527	aspartate kinase activity
HV352_RS22400	COG0460	homoserine dehydrogenase
HV352_RS22405	COG0626	cystathionine gamma-synthase activity
HV352_RS22415	COG2211	Major facilitator Superfamily
HV352_RS22430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV352_RS22435	COG1609	Transcriptional regulator
HV352_RS22440	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV352_RS22455	COG1575	Belongs to the MenA family. Type 1 subfamily
HV352_RS22465	COG3074	FtsZ-dependent cytokinesis
HV352_RS22470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV352_RS22480	COG1494	fructose-1,6-bisphosphatase
HV352_RS22490	COG3152	Membrane
HV352_RS22515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV352_RS22530	COG3678	ATP-independent chaperone mediated protein folding
HV352_RS22535	COG0745	RESPONSE REGULATOR receiver
HV352_RS22540	COG2205	protein histidine kinase activity
HV352_RS22545	COG2271	Major facilitator Superfamily
HV352_RS22550	COG1082	Xylose isomerase domain protein TIM barrel
HV352_RS22555	COG2188	Transcriptional regulator
HV352_RS22560	COG2258	MOSC domain
HV352_RS22565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV352_RS22590	COG0738	Major facilitator superfamily
HV352_RS22595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV352_RS22595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS22595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS22600	COG0383	alpha-mannosidase activity
HV352_RS22605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS22610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS22645	COG1454	alcohol dehydrogenase
HV352_RS22665	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV352_RS22675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS22680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS22680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV352_RS22685	COG1363	Peptidase, m42
HV352_RS22690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV352_RS22690	COG3711	transcriptional antiterminator
HV352_RS22710	COG0437	4 iron, 4 sulfur cluster binding
HV352_RS22715	COG2864	formate dehydrogenase
HV352_RS22730	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV352_RS22740	COG4680	protein conserved in bacteria
HV352_RS22745	COG5499	transcription regulator containing HTH domain
HV352_RS22750	COG0456	acetyltransferase
HV352_RS22765	COG1011	Hydrolase
HV352_RS22770	COG1349	DNA-binding transcription factor activity
HV352_RS22775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS22785	COG3684	Belongs to the aldolase LacD family
HV352_RS22795	COG2017	converts alpha-aldose to the beta-anomer
HV352_RS22800	COG1501	Belongs to the glycosyl hydrolase 31 family
HV352_RS22830	COG3852	Histidine kinase
HV352_RS22835	COG2204	response regulator
HV352_RS22845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV352_RS22870	COG0204	Acyl-transferase
HV352_RS22885	COG3084	Protein conserved in bacteria
HV352_RS22890	COG0746	molybdenum cofactor guanylyltransferase activity
HV352_RS22895	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV352_RS22935	COG1739	Uncharacterized protein family UPF0029
HV352_RS22955	COG1609	Transcriptional regulator
HV352_RS22960	COG1940	carbohydrate kinase activity
HV352_RS22970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV352_RS22985	COG0805	protein transport
HV352_RS23030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV352_RS23035	COG0583	DNA-binding transcription factor activity
HV352_RS23040	COG0697	spore germination
HV352_RS23045	COG0561	phosphatase activity
HV352_RS23050	COG2267	carboxylic ester hydrolase activity
HV352_RS23055	COG1280	lysine exporter protein (LysE YggA)
HV352_RS23060	COG1280	lysine exporter protein (LysE YggA)
HV352_RS23095	COG1011	Hydrolase
HV352_RS23140	COG2959	enzyme of heme biosynthesis
HV352_RS23145	COG3071	HemY protein
HV352_RS23190	COG2244	polysaccharide biosynthetic process
HV352_RS23195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV352_RS23200	COG0456	acetyltransferase
HV352_RS23205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV352_RS23210	COG1088	dTDP-glucose 4,6-dehydratase activity
HV352_RS23215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV352_RS23230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV352_RS23235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV352_RS23245	COG3118	belongs to the thioredoxin family
HV352_RS23265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV352_RS23285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV352_RS23295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV352_RS23300	COG3978	acetolactate synthase activity
HV352_RS23320	COG3085	chromosome segregation
HV352_RS23360	COG2186	Transcriptional regulator
HV352_RS23365	COG0477	Major facilitator Superfamily
HV352_RS23370	COG1609	Transcriptional regulator
HV352_RS23375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV352_RS23380	COG1879	ABC-type sugar transport system periplasmic component
HV352_RS23385	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV352_RS23395	COG1869	D-ribose catabolic process
HV352_RS23420	COG1522	sequence-specific DNA binding
HV352_RS23425	COG0716	FMN binding
HV352_RS23440	COG3312	ion transport
HV352_RS23465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV352_RS23475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV352_RS23480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV352_RS23495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV352_RS23500	COG0573	inorganic phosphate transmembrane transporter activity
HV352_RS23505	COG0581	inorganic phosphate transmembrane transporter activity
HV352_RS23515	COG0704	Plays a role in the regulation of phosphate uptake
HV352_RS23520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV352_RS23525	COG2252	PERMEase
HV352_RS23530	COG0431	NADPH-dependent FMN reductase
HV352_RS23535	COG2091	lysine biosynthetic process via aminoadipic acid
HV352_RS23570	COG0230	Belongs to the bacterial ribosomal protein bL34 family