locus-tag	class	description
WG74_RS00045	COG1987	bacterial-type flagellum assembly
WG74_RS00050	COG1684	flagellar biosynthetic protein fliR
WG74_RS00060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WG74_RS00070	COG4566	intracellular signal transduction
WG74_RS00075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WG74_RS00100	COG0717	Belongs to the dCTP deaminase family
WG74_RS00105	COG3268	Saccharopine dehydrogenase
WG74_RS00125	COG3118	belongs to the thioredoxin family
WG74_RS00140	COG2095	MarC family integral membrane protein
WG74_RS00150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WG74_RS00160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WG74_RS00175	COG2116	formate transmembrane transporter activity
WG74_RS00200	COG1372	Participates in initiation and elongation during chromosome replication
WG74_RS00200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WG74_RS00225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WG74_RS00225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WG74_RS00260	COG1131	(ABC) transporter
WG74_RS00290	COG1902	pentaerythritol trinitrate reductase activity
WG74_RS00305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WG74_RS00305	COG0519	Catalyzes the synthesis of GMP from XMP
WG74_RS00315	COG1760	l-serine dehydratase
WG74_RS00330	COG2081	HI0933 family
WG74_RS00345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WG74_RS00355	COG2824	Alkylphosphonate utilization operon protein PhnA
WG74_RS00360	COG1960	acyl-CoA dehydrogenase activity
WG74_RS00370	COG1125	glycine betaine transport
WG74_RS00370	COG0517	IMP dehydrogenase activity
WG74_RS00390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WG74_RS00395	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS00400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WG74_RS00420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WG74_RS00425	COG0352	thiamine-phosphate diphosphorylase activity
WG74_RS00435	COG0667	Aldo Keto reductase
WG74_RS00470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WG74_RS00475	COG0686	Belongs to the AlaDH PNT family
WG74_RS00500	COG3655	Transcriptional regulator
WG74_RS00555	COG0433	COG0433 Predicted ATPase
WG74_RS00565	COG0564	pseudouridine synthase activity
WG74_RS00575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WG74_RS00585	COG1785	Belongs to the alkaline phosphatase family
WG74_RS00595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WG74_RS00595	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WG74_RS00615	COG1960	acyl-CoA dehydrogenase activity
WG74_RS00620	COG0183	Belongs to the thiolase family
WG74_RS00625	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
WG74_RS00630	COG3186	Phenylalanine-4-hydroxylase
WG74_RS00645	COG1968	undecaprenyl-diphosphatase activity
WG74_RS00655	COG1132	(ABC) transporter
WG74_RS00675	COG0183	Belongs to the thiolase family
WG74_RS00690	COG0438	transferase activity, transferring glycosyl groups
WG74_RS00700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WG74_RS00730	COG0495	leucyl-tRNA aminoacylation
WG74_RS00770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WG74_RS00780	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS00785	COG0739	heme binding
WG74_RS00790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WG74_RS00795	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WG74_RS00815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WG74_RS00830	COG1476	TRANSCRIPTIONal
WG74_RS00845	COG2902	Dehydrogenase
WG74_RS00855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WG74_RS00860	COG4152	abc transporter atp-binding protein
WG74_RS00890	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
WG74_RS00905	COG0776	regulation of translation
WG74_RS00910	COG2188	Transcriptional regulator
WG74_RS00915	COG3104	oligopeptide transport
WG74_RS00920	COG1228	amidohydrolase
WG74_RS00930	COG0545	Peptidyl-prolyl cis-trans isomerase
WG74_RS00940	COG1024	Enoyl-CoA hydratase
WG74_RS00955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WG74_RS00965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WG74_RS00970	COG0138	bifunctional purine biosynthesis protein purh
WG74_RS01015	COG0330	HflC and HflK could
WG74_RS01035	COG2070	2-Nitropropane dioxygenase
WG74_RS01050	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WG74_RS01055	COG0527	aspartate kinase activity
WG74_RS01060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WG74_RS01065	COG0584	glycerophosphoryl diester phosphodiesterase
WG74_RS01070	COG1393	Belongs to the ArsC family
WG74_RS01085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WG74_RS01090	COG0217	transcriptional regulatory protein
WG74_RS01095	COG0393	Putative heavy-metal-binding
WG74_RS01100	COG3750	Belongs to the UPF0335 family
WG74_RS01110	COG0469	pyruvate kinase activity
WG74_RS01125	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WG74_RS01125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WG74_RS01130	COG5001	Diguanylate cyclase
WG74_RS01140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WG74_RS01150	COG0085	RNA polymerase activity
WG74_RS01160	COG3655	Transcriptional regulator
WG74_RS01175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WG74_RS01180	COG0222	ribosome binding
WG74_RS01190	COG0475	glutathione-regulated potassium exporter activity
WG74_RS01190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WG74_RS01200	COG0668	transmembrane transport
WG74_RS01205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WG74_RS01210	COG0459	protein refolding
WG74_RS01235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WG74_RS01235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WG74_RS01240	COG3920	Histidine kinase
WG74_RS01245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WG74_RS01245	COG3264	Mechanosensitive ion channel
WG74_RS01255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WG74_RS01270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WG74_RS01285	COG2311	Membrane
WG74_RS01290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WG74_RS01295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WG74_RS01305	COG2890	protein-(glutamine-N5) methyltransferase activity
WG74_RS01310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WG74_RS01315	COG0124	histidyl-tRNA synthetase
WG74_RS01325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WG74_RS01335	COG0668	transmembrane transport
WG74_RS01345	COG1137	ATPase activity
WG74_RS01350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WG74_RS01355	COG0077	Prephenate dehydratase
WG74_RS01370	COG0668	transmembrane transport
WG74_RS01375	COG0471	metal ion transport
WG74_RS01375	COG3273	potassium ion transport
WG74_RS01380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WG74_RS01390	COG1802	Transcriptional regulator
WG74_RS01405	COG3920	Histidine kinase
WG74_RS01410	COG0784	Response regulator, receiver
WG74_RS01435	COG1742	UPF0060 membrane protein
WG74_RS01440	COG0798	PFAM Bile acid sodium symporter
WG74_RS01460	COG2771	luxR family
WG74_RS01475	COG4771	TonB-dependent receptor
WG74_RS01480	COG1506	peptidase
WG74_RS01480	COG0823	Involved in the tonB-independent uptake of proteins
WG74_RS01500	COG2948	multi-organism process
WG74_RS01515	COG3846	protein secretion by the type IV secretion system
WG74_RS01530	COG3451	type IV secretory pathway VirB4
WG74_RS01545	COG4962	Type ii secretion system protein e
WG74_RS01550	COG1104	cysteine desulfurase activity
WG74_RS01610	COG0741	lytic transglycosylase activity
WG74_RS01645	COG0629	single-stranded DNA binding
WG74_RS01680	COG2132	Multicopper oxidase
WG74_RS01700	COG2264	protein methyltransferase activity
WG74_RS01740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WG74_RS01740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WG74_RS01760	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WG74_RS01770	COG2132	Multicopper oxidase
WG74_RS01785	COG0672	)-iron permease
WG74_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS01805	COG0028	Belongs to the TPP enzyme family
WG74_RS01860	COG4227	nucleotidyltransferase activity
WG74_RS01900	COG3550	peptidyl-serine autophosphorylation
WG74_RS01935	COG0281	malic enzyme
WG74_RS01935	COG0280	phosphate acetyltransferase
WG74_RS01940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WG74_RS01955	COG1250	3-hydroxyacyl-CoA dehydrogenase
WG74_RS01970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WG74_RS01985	COG0667	Aldo Keto reductase
WG74_RS01995	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WG74_RS02000	COG3483	tryptophan 2,3-dioxygenase activity
WG74_RS02050	COG0784	Response regulator, receiver
WG74_RS02060	COG0156	8-amino-7-oxononanoate synthase activity
WG74_RS02065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WG74_RS02065	COG3453	Protein conserved in bacteria
WG74_RS02070	COG0640	Transcriptional regulator
WG74_RS02075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WG74_RS02085	COG1764	response to oxidative stress
WG74_RS02130	COG4695	Portal protein
WG74_RS02210	COG2885	chlorophyll binding
WG74_RS02210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WG74_RS02215	COG2032	superoxide dismutase activity
WG74_RS02225	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WG74_RS02240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WG74_RS02245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WG74_RS02250	COG1278	Cold shock
WG74_RS02290	COG4221	oxidoreductase activity
WG74_RS02295	COG0072	phenylalanine-tRNA ligase activity
WG74_RS02300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WG74_RS02305	COG2827	Endonuclease containing a URI domain
WG74_RS02310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WG74_RS02315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WG74_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS02350	COG1494	fructose-1,6-bisphosphatase
WG74_RS02395	COG1201	RNA secondary structure unwinding
WG74_RS02415	COG1192	Involved in chromosome partitioning
WG74_RS02420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WG74_RS02430	COG0175	sulfate reduction
WG74_RS02455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WG74_RS02460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WG74_RS02460	COG2857	Cytochrome c1
WG74_RS02470	COG0723	plastoquinol--plastocyanin reductase activity
WG74_RS02475	COG1496	oxidoreductase activity
WG74_RS02480	COG0308	aminopeptidase N
WG74_RS02520	COG0588	phosphoglycerate mutase activity
WG74_RS02525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WG74_RS02530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WG74_RS02545	COG0196	riboflavin kinase activity
WG74_RS02550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WG74_RS02555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WG74_RS02575	COG3275	phosphorelay sensor kinase activity
WG74_RS02580	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WG74_RS02580	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WG74_RS02600	COG1506	peptidase
WG74_RS02600	COG0823	Involved in the tonB-independent uptake of proteins
WG74_RS02605	COG3411	Ferredoxin
WG74_RS02620	COG0316	Belongs to the HesB IscA family
WG74_RS02630	COG3409	Peptidoglycan-binding domain 1 protein
WG74_RS02630	COG3773	Cell wall hydrolase
WG74_RS02650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WG74_RS02655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WG74_RS02660	COG0237	dephospho-CoA kinase activity
WG74_RS02665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WG74_RS02670	COG0424	maF-like protein
WG74_RS02675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WG74_RS02680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WG74_RS02685	COG1981	membrane
WG74_RS02690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WG74_RS02715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WG74_RS02720	COG0445	tRNA wobble uridine modification
WG74_RS02725	COG0357	Ribosomal RNA small subunit methyltransferase G
WG74_RS02745	COG1956	GAF domain-containing protein
WG74_RS02755	COG1960	acyl-CoA dehydrogenase activity
WG74_RS02760	COG0009	L-threonylcarbamoyladenylate synthase
WG74_RS02775	COG1329	Transcriptional regulator
WG74_RS02780	COG1295	ribonuclease BN
WG74_RS02790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WG74_RS02805	COG0739	heme binding
WG74_RS02810	COG0113	porphobilinogen synthase activity
WG74_RS02825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WG74_RS02835	COG1872	DUF167
WG74_RS02845	COG1793	dna ligase
WG74_RS02885	COG0438	transferase activity, transferring glycosyl groups
WG74_RS02895	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS02905	COG0739	heme binding
WG74_RS02910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WG74_RS02915	COG0799	negative regulation of ribosome biogenesis
WG74_RS02920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WG74_RS02930	COG0793	Belongs to the peptidase S41A family
WG74_RS02940	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WG74_RS02950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WG74_RS02960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WG74_RS02965	COG0489	protein tyrosine kinase activity
WG74_RS02965	COG3206	protein involved in exopolysaccharide biosynthesis
WG74_RS02985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WG74_RS02990	COG1295	ribonuclease BN
WG74_RS02995	COG0484	heat shock protein binding
WG74_RS03000	COG1482	cell wall glycoprotein biosynthetic process
WG74_RS03010	COG0259	pyridoxamine-phosphate oxidase activity
WG74_RS03015	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WG74_RS03035	COG0482	sulfurtransferase activity
WG74_RS03060	COG2733	membrane
WG74_RS03070	COG2086	electron transfer activity
WG74_RS03075	COG3932	Exopolysaccharide synthesis, ExoD
WG74_RS03080	COG0045	succinate-CoA ligase (ADP-forming) activity
WG74_RS03085	COG0483	inositol monophosphate 1-phosphatase activity
WG74_RS03095	COG1253	flavin adenine dinucleotide binding
WG74_RS03110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WG74_RS03115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WG74_RS03125	COG1324	tolerance protein
WG74_RS03130	COG1612	heme a metabolic process
WG74_RS03140	COG2022	thiamine diphosphate biosynthetic process
WG74_RS03160	COG0405	Gamma-glutamyltransferase
WG74_RS03165	COG0167	dihydroorotate dehydrogenase activity
WG74_RS03180	COG0719	Fe-S assembly protein
WG74_RS03205	COG0396	ATPase activity
WG74_RS03210	COG0719	Fe-S assembly protein
WG74_RS03220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WG74_RS03225	COG2151	metal-sulfur cluster biosynthetic enzyme
WG74_RS03230	COG0316	Belongs to the HesB IscA family
WG74_RS03245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WG74_RS03255	COG0151	Belongs to the GarS family
WG74_RS03260	COG1570	exodeoxyribonuclease VII activity
WG74_RS03275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WG74_RS03280	COG0590	tRNA wobble adenosine to inosine editing
WG74_RS03305	COG3275	phosphorelay sensor kinase activity
WG74_RS03315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WG74_RS03375	COG1024	Enoyl-CoA hydratase
WG74_RS03380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WG74_RS03425	COG1758	RNA polymerase activity
WG74_RS03435	COG5328	Belongs to the UPF0262 family
WG74_RS03445	COG0295	cytidine deaminase activity
WG74_RS03450	COG2866	Carboxypeptidase
WG74_RS03460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WG74_RS03500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WG74_RS03510	COG0583	DNA-binding transcription factor activity
WG74_RS03520	COG2366	antibiotic biosynthetic process
WG74_RS03535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WG74_RS03540	COG0594	ribonuclease P activity
WG74_RS03545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WG74_RS03550	COG0706	membrane insertase activity
WG74_RS03555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WG74_RS03560	COG0625	glutathione transferase activity
WG74_RS03575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WG74_RS03580	COG1301	dicarboxylic acid transport
WG74_RS03590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WG74_RS03595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WG74_RS03605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WG74_RS03615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WG74_RS03620	COG0268	Binds directly to 16S ribosomal RNA
WG74_RS03625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WG74_RS03630	COG2226	methyltransferase
WG74_RS03640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WG74_RS03645	COG0756	dUTP diphosphatase activity
WG74_RS03655	COG0180	Tryptophanyl-tRNA synthetase
WG74_RS03660	COG0728	peptidoglycan biosynthetic process
WG74_RS03665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WG74_RS03670	COG4395	Tim44
WG74_RS03700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WG74_RS03715	COG0450	alkyl hydroperoxide reductase
WG74_RS03725	COG0402	S-adenosylhomocysteine deaminase activity
WG74_RS03735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WG74_RS03745	COG0632	four-way junction helicase activity
WG74_RS03760	COG2255	four-way junction helicase activity
WG74_RS03770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WG74_RS03780	COG2989	Protein conserved in bacteria
WG74_RS03800	COG0123	including yeast histone deacetylase and acetoin utilization protein
WG74_RS03805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WG74_RS03810	COG2067	long-chain fatty acid transport protein
WG74_RS03830	COG1446	asparaginase
WG74_RS03855	COG0714	Associated with various cellular activities
WG74_RS03875	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WG74_RS03890	COG1611	Belongs to the LOG family
WG74_RS03895	COG0351	phosphomethylpyrimidine kinase
WG74_RS03895	COG0352	thiamine-phosphate diphosphorylase activity
WG74_RS03900	COG3813	Protein conserved in bacteria
WG74_RS03905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WG74_RS03935	COG3920	Histidine kinase
WG74_RS03940	COG0784	Response regulator, receiver
WG74_RS03970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WG74_RS03980	COG3243	poly(R)-hydroxyalkanoic acid synthase
WG74_RS03985	COG0436	Aminotransferase
WG74_RS03990	COG1024	Enoyl-CoA hydratase
WG74_RS04010	COG0129	dihydroxy-acid dehydratase activity
WG74_RS04015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WG74_RS04030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WG74_RS04035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WG74_RS04040	COG0066	3-isopropylmalate dehydratase activity
WG74_RS04045	COG0473	3-isopropylmalate dehydrogenase activity
WG74_RS04070	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS04080	COG1937	Protein conserved in bacteria
WG74_RS04085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WG74_RS04095	COG3706	GGDEF domain
WG74_RS04100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WG74_RS04105	COG0662	Cupin 2, conserved barrel domain protein
WG74_RS04120	COG2226	methyltransferase
WG74_RS04135	COG0456	acetyltransferase
WG74_RS04145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WG74_RS04150	COG0509	glycine decarboxylation via glycine cleavage system
WG74_RS04160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WG74_RS04165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WG74_RS04185	COG1024	Enoyl-CoA hydratase
WG74_RS04190	COG0346	lactoylglutathione lyase activity
WG74_RS04250	COG3706	GGDEF domain
WG74_RS04260	COG0783	Belongs to the Dps family
WG74_RS04280	COG4770	biotin carboxylase activity
WG74_RS04315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WG74_RS04335	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WG74_RS04345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WG74_RS04380	COG1671	Belongs to the UPF0178 family
WG74_RS04395	COG1278	Cold shock
WG74_RS04410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WG74_RS04430	COG3920	Histidine kinase
WG74_RS04480	COG2171	N-acyltransferase activity
WG74_RS04490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WG74_RS04495	COG1960	acyl-CoA dehydrogenase activity
WG74_RS04500	COG2211	Major facilitator Superfamily
WG74_RS04505	COG1960	acyl-CoA dehydrogenase activity
WG74_RS04510	COG1960	acyl-CoA dehydrogenase activity
WG74_RS04525	COG0194	GDP metabolic process
WG74_RS04540	COG0131	Imidazoleglycerol-phosphate dehydratase
WG74_RS04545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WG74_RS04550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WG74_RS04560	COG0107	imidazoleglycerol-phosphate synthase activity
WG74_RS04565	COG0140	phosphoribosyl-ATP diphosphatase activity
WG74_RS04575	COG0824	Thioesterase
WG74_RS04585	COG0848	biopolymer transport protein
WG74_RS04595	COG0823	Involved in the tonB-independent uptake of proteins
WG74_RS04600	COG2885	chlorophyll binding
WG74_RS04625	COG4771	TonB-dependent receptor
WG74_RS04630	COG0626	cystathionine gamma-synthase activity
WG74_RS04645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WG74_RS04655	COG0408	coproporphyrinogen oxidase activity
WG74_RS04695	COG0582	viral genome integration into host DNA
WG74_RS04725	COG1815	bacterial-type flagellum-dependent cell motility
WG74_RS04735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WG74_RS04745	COG1766	The M ring may be actively involved in energy transduction
WG74_RS04750	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WG74_RS04755	COG2204	response regulator
WG74_RS04760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WG74_RS04780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WG74_RS04795	COG4786	Flagellar basal body rod
WG74_RS04800	COG4786	Flagellar basal body rod
WG74_RS04855	COG5443	negative regulation of bacterial-type flagellum assembly
WG74_RS04880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WG74_RS04885	COG1696	Membrane protein involved in D-alanine export
WG74_RS04940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WG74_RS04945	COG5001	Diguanylate cyclase
WG74_RS04960	COG2884	Cell division ATP-binding protein ftsE
WG74_RS04980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WG74_RS04985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WG74_RS04995	COG2813	Specifically methylates the guanine in position
WG74_RS04995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WG74_RS05005	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
WG74_RS05010	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
WG74_RS05030	COG0500	methyltransferase
WG74_RS05035	COG1063	alcohol dehydrogenase
WG74_RS05040	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
WG74_RS05045	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WG74_RS05050	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WG74_RS05075	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
WG74_RS05080	COG0644	oxidoreductase
WG74_RS05085	COG2211	Major facilitator Superfamily
WG74_RS05090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WG74_RS05100	COG5012	cobalamin binding
WG74_RS05110	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WG74_RS05115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WG74_RS05120	COG1429	ligase activity, forming nitrogen-metal bonds
WG74_RS05125	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
WG74_RS05160	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
WG74_RS05170	COG0156	8-amino-7-oxononanoate synthase activity
WG74_RS05210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WG74_RS05220	COG0330	HflC and HflK could
WG74_RS05230	COG0489	protein tyrosine kinase activity
WG74_RS05240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WG74_RS05255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WG74_RS05255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WG74_RS05270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WG74_RS05305	COG1082	Xylose isomerase domain protein TIM barrel
WG74_RS05310	COG0366	Alpha amylase catalytic
WG74_RS05345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WG74_RS05350	COG0363	glucosamine-6-phosphate deaminase activity
WG74_RS05355	COG0129	dihydroxy-acid dehydratase activity
WG74_RS05360	COG0837	glucose binding
WG74_RS05365	COG0800	Aldolase
WG74_RS05370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WG74_RS05410	COG1294	oxidase, subunit
WG74_RS05415	COG1271	oxidase subunit
WG74_RS05420	COG5001	Diguanylate cyclase
WG74_RS05420	COG5002	protein histidine kinase activity
WG74_RS05420	COG3447	MASE1 domain protein
WG74_RS05430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WG74_RS05435	COG2308	Evidence 4 Homologs of previously reported genes of
WG74_RS05445	COG1305	Transglutaminase-like
WG74_RS05500	COG4555	ABC transporter
WG74_RS05515	COG2146	nitrite reductase [NAD(P)H] activity
WG74_RS05525	COG2130	NADP-dependent
WG74_RS05535	COG4771	TonB-dependent receptor
WG74_RS05540	COG2130	NADP-dependent
WG74_RS05550	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS05555	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS05565	COG4638	Rieske (2fe-2S)
WG74_RS05600	COG1960	acyl-CoA dehydrogenase activity
WG74_RS05620	COG0183	Belongs to the thiolase family
WG74_RS05625	COG1960	acyl-CoA dehydrogenase activity
WG74_RS05630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WG74_RS05635	COG0022	dehydrogenase e1 component
WG74_RS05640	COG0508	dehydrogenase complex catalyzes the overall conversion of
WG74_RS05680	COG0823	Involved in the tonB-independent uptake of proteins
WG74_RS05680	COG4946	Tricorn protease homolog
WG74_RS05680	COG1506	peptidase
WG74_RS05695	COG1566	PFAM secretion protein HlyD family protein
WG74_RS05705	COG1999	signal sequence binding
WG74_RS05710	COG2847	Copper chaperone PCu(A)C
WG74_RS05725	COG0667	Aldo Keto reductase
WG74_RS05735	COG0577	efflux transmembrane transporter activity
WG74_RS05740	COG1136	(ABC) transporter
WG74_RS05750	COG2204	response regulator
WG74_RS05755	COG0642	Histidine kinase
WG74_RS05765	COG5001	Diguanylate cyclase
WG74_RS05765	COG2203	Gaf domain
WG74_RS05765	COG3706	GGDEF domain
WG74_RS05765	COG4251	negative regulation of phosphorylation
WG74_RS05825	COG4771	TonB-dependent receptor
WG74_RS05850	COG1797	cobyrinic acid a,c-diamide synthase activity
WG74_RS05865	COG4206	TonB-dependent receptor
WG74_RS05875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
WG74_RS05885	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
WG74_RS05900	COG1492	cobalamin metabolic process
WG74_RS05925	COG0745	RESPONSE REGULATOR receiver
WG74_RS05940	COG0463	Glycosyl transferase, family 2
WG74_RS05945	COG1216	Glycosyl transferase, family 2
WG74_RS05945	COG0463	Glycosyl transferase, family 2
WG74_RS05990	COG1960	acyl-CoA dehydrogenase activity
WG74_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS06005	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WG74_RS06015	COG1024	Enoyl-CoA hydratase
WG74_RS06020	COG4771	TonB-dependent receptor
WG74_RS06030	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS06055	COG0667	Aldo Keto reductase
WG74_RS06060	COG2124	cytochrome p450
WG74_RS06090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WG74_RS06100	COG4770	biotin carboxylase activity
WG74_RS06110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WG74_RS06110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WG74_RS06120	COG1024	Enoyl-CoA hydratase
WG74_RS06125	COG0346	lactoylglutathione lyase activity
WG74_RS06130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WG74_RS06155	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS06160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WG74_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS06185	COG4638	Rieske (2fe-2S)
WG74_RS06190	COG1960	acyl-CoA dehydrogenase activity
WG74_RS06195	COG1960	acyl-CoA dehydrogenase activity
WG74_RS06210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WG74_RS06215	COG0183	Belongs to the thiolase family
WG74_RS06225	COG1960	acyl-CoA dehydrogenase activity
WG74_RS06235	COG1024	Enoyl-CoA hydratase
WG74_RS06255	COG1024	Enoyl-CoA hydratase
WG74_RS06275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WG74_RS06395	COG0582	viral genome integration into host DNA
WG74_RS06410	COG1448	Aminotransferase
WG74_RS06445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WG74_RS06445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WG74_RS06460	COG2983	Belongs to the UPF0260 family
WG74_RS06465	COG1999	signal sequence binding
WG74_RS06490	COG0629	single-stranded DNA binding
WG74_RS06500	COG0488	(ABC) transporter
WG74_RS06510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WG74_RS06515	COG0569	domain protein
WG74_RS06540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WG74_RS06545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WG74_RS06560	COG0659	secondary active sulfate transmembrane transporter activity
WG74_RS06570	COG5265	(ABC) transporter
WG74_RS06585	COG0463	Glycosyl transferase, family 2
WG74_RS06585	COG1216	Glycosyl transferase, family 2
WG74_RS06635	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
WG74_RS06640	COG2080	2 iron, 2 sulfur cluster binding
WG74_RS06645	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WG74_RS06650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WG74_RS06660	COG0435	Glutathione S-transferase
WG74_RS06675	COG0114	fumarate hydratase activity
WG74_RS06680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WG74_RS06695	COG2226	methyltransferase
WG74_RS06720	COG0534	Mate efflux family protein
WG74_RS06725	COG0235	Class ii aldolase
WG74_RS06755	COG1393	Belongs to the ArsC family
WG74_RS06770	COG0321	lipoyl(octanoyl) transferase activity
WG74_RS06780	COG1902	pentaerythritol trinitrate reductase activity
WG74_RS06800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WG74_RS06815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WG74_RS06840	COG1426	Protein conserved in bacteria
WG74_RS06850	COG0037	tRNA processing
WG74_RS06865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WG74_RS06880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WG74_RS06885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WG74_RS06900	COG0745	RESPONSE REGULATOR receiver
WG74_RS06935	COG0616	signal peptide processing
WG74_RS06940	COG0540	Belongs to the ATCase OTCase family
WG74_RS06945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WG74_RS06970	COG2311	Membrane
WG74_RS06985	COG2193	ferroxidase activity
WG74_RS06995	COG1160	GTP binding
WG74_RS07020	COG0544	peptidyl-prolyl cis-trans isomerase activity
WG74_RS07025	COG0154	amidase activity
WG74_RS07030	COG0740	serine-type endopeptidase activity
WG74_RS07035	COG0740	serine-type endopeptidase activity
WG74_RS07040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WG74_RS07045	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WG74_RS07055	COG1595	DNA-templated transcription, initiation
WG74_RS07065	COG1230	cation diffusion facilitator family transporter
WG74_RS07075	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
WG74_RS07080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WG74_RS07085	COG0564	pseudouridine synthase activity
WG74_RS07100	COG3023	N-Acetylmuramoyl-L-alanine amidase
WG74_RS07110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WG74_RS07115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WG74_RS07120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WG74_RS07135	COG0730	response to heat
WG74_RS07155	COG3228	Belongs to the MtfA family
WG74_RS07160	COG0525	valine-tRNA ligase activity
WG74_RS07165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WG74_RS07170	COG1127	ABC transporter
WG74_RS07195	COG0546	phosphoglycolate phosphatase activity
WG74_RS07205	COG0564	pseudouridine synthase activity
WG74_RS07210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WG74_RS07215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WG74_RS07220	COG0545	Peptidyl-prolyl cis-trans isomerase
WG74_RS07230	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WG74_RS07235	COG0154	amidase activity
WG74_RS07240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WG74_RS07265	COG0612	Peptidase, M16
WG74_RS07275	COG0542	response to heat
WG74_RS07285	COG4206	TonB-dependent receptor
WG74_RS07315	COG0183	Belongs to the thiolase family
WG74_RS07325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WG74_RS07330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WG74_RS07355	COG4964	Belongs to the GSP D family
WG74_RS07380	COG0328	RNA-DNA hybrid ribonuclease activity
WG74_RS07390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WG74_RS07400	COG0018	arginyl-trna synthetase
WG74_RS07410	COG1472	Belongs to the glycosyl hydrolase 3 family
WG74_RS07415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WG74_RS07420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WG74_RS07425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WG74_RS07430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WG74_RS07435	COG0805	protein transport
WG74_RS07460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WG74_RS07465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WG74_RS07470	COG0729	surface antigen
WG74_RS07480	COG1476	TRANSCRIPTIONal
WG74_RS07490	COG0174	glutamine synthetase
WG74_RS07495	COG0347	Belongs to the P(II) protein family
WG74_RS07520	COG0024	Methionine aminopeptidase
WG74_RS07525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WG74_RS07530	COG4133	protoheme IX ABC transporter activity
WG74_RS07535	COG2154	pterin-4-alpha-carbinolamine dehydratase
WG74_RS07560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WG74_RS07575	COG2001	Belongs to the MraZ family
WG74_RS07580	COG0275	rRNA processing
WG74_RS07595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WG74_RS07605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WG74_RS07610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WG74_RS07620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WG74_RS07625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WG74_RS07630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WG74_RS07640	COG1181	Belongs to the D-alanine--D-alanine ligase family
WG74_RS07645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WG74_RS07650	COG0849	cell division
WG74_RS07670	COG0670	Belongs to the BI1 family
WG74_RS07685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WG74_RS07690	COG1090	epimerase
WG74_RS07700	COG0175	sulfate reduction
WG74_RS07720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WG74_RS07720	COG1648	precorrin-2 dehydrogenase activity
WG74_RS07730	COG0626	cystathionine gamma-synthase activity
WG74_RS07735	COG2897	thiosulfate sulfurtransferase activity
WG74_RS07745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WG74_RS07775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WG74_RS07780	COG1695	Transcriptional regulator
WG74_RS07790	COG0438	transferase activity, transferring glycosyl groups
WG74_RS07800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WG74_RS07805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WG74_RS07820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WG74_RS07830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WG74_RS07830	COG1648	precorrin-2 dehydrogenase activity
WG74_RS07835	COG0019	diaminopimelate decarboxylase activity
WG74_RS07845	COG0165	Argininosuccinate lyase
WG74_RS07850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WG74_RS07865	COG0252	asparaginase activity
WG74_RS07875	COG0101	tRNA pseudouridine synthase activity
WG74_RS07885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WG74_RS07890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WG74_RS07895	COG0242	peptide deformylase activity
WG74_RS07905	COG1322	Protein conserved in bacteria
WG74_RS07950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WG74_RS07960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
WG74_RS07960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WG74_RS07965	COG1660	Displays ATPase and GTPase activities
WG74_RS07970	COG2205	protein histidine kinase activity
WG74_RS07975	COG0745	RESPONSE REGULATOR receiver
WG74_RS07980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WG74_RS08000	COG0492	ferredoxin-NADP+ reductase activity
WG74_RS08025	COG2945	thiolester hydrolase activity
WG74_RS08030	COG1104	cysteine desulfurase activity
WG74_RS08035	COG1104	cysteine desulfurase activity
WG74_RS08050	COG0693	protein deglycase activity
WG74_RS08055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WG74_RS08075	COG0617	tRNA 3'-terminal CCA addition
WG74_RS08080	COG0494	nUDIX hydrolase
WG74_RS08095	COG2133	pyrroloquinoline quinone binding
WG74_RS08100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WG74_RS08105	COG0300	oxidoreductase activity
WG74_RS08115	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WG74_RS08125	COG3609	addiction module antidote protein, CC2985 family
WG74_RS08135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WG74_RS08140	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS08165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WG74_RS08195	COG2267	carboxylic ester hydrolase activity
WG74_RS08200	COG1794	racemase activity, acting on amino acids and derivatives
WG74_RS08205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WG74_RS08240	COG0697	spore germination
WG74_RS08260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WG74_RS08265	COG5001	Diguanylate cyclase
WG74_RS08270	COG0047	phosphoribosylformylglycinamidine synthase activity
WG74_RS08275	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WG74_RS08280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WG74_RS08305	COG0655	NAD(P)H dehydrogenase (quinone) activity
WG74_RS08315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WG74_RS08325	COG0424	maF-like protein
WG74_RS08330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WG74_RS08335	COG4206	TonB-dependent receptor
WG74_RS08345	COG0322	excinuclease ABC activity
WG74_RS08385	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WG74_RS08400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WG74_RS08405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WG74_RS08410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WG74_RS08420	COG0596	Alpha beta hydrolase
WG74_RS08425	COG0300	oxidoreductase activity
WG74_RS08430	COG1741	Belongs to the pirin family
WG74_RS08470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WG74_RS08575	COG2842	Transposition protein
WG74_RS08580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WG74_RS08650	COG4373	Mu-like prophage FluMu protein gp28
WG74_RS08680	COG4397	Mu-like prophage major head subunit gpT
WG74_RS08765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WG74_RS08775	COG0628	permease
WG74_RS08780	COG0681	Belongs to the peptidase S26 family
WG74_RS08785	COG0736	holo-[acyl-carrier-protein] synthase activity
WG74_RS08795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WG74_RS08805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WG74_RS08810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WG74_RS08810	COG1565	acr, cog1565
WG74_RS08815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WG74_RS08820	COG0109	protoheme IX farnesyltransferase activity
WG74_RS08830	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WG74_RS08850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WG74_RS08865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WG74_RS08875	COG0314	molybdopterin synthase activity
WG74_RS08890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WG74_RS08895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WG74_RS08900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WG74_RS08915	COG2819	hydrolase of the alpha beta superfamily
WG74_RS08920	COG0354	folic acid binding
WG74_RS08925	COG0418	dihydroorotase activity
WG74_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS08940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WG74_RS08975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WG74_RS08985	COG1199	ATP-dependent helicase activity
WG74_RS08985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WG74_RS09000	COG0789	Transcriptional regulator
WG74_RS09005	COG0346	lactoylglutathione lyase activity
WG74_RS09010	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WG74_RS09045	COG1254	Belongs to the acylphosphatase family
WG74_RS09050	COG1309	transcriptional regulator
WG74_RS09065	COG2119	membrane
WG74_RS09070	COG0488	(ABC) transporter
WG74_RS09075	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
WG74_RS09175	COG1522	sequence-specific DNA binding
WG74_RS09195	COG0439	Biotin carboxylase
WG74_RS09200	COG0511	ligase activity, forming carbon-carbon bonds
WG74_RS09205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WG74_RS09215	COG1846	Transcriptional regulator
WG74_RS09220	COG1764	response to oxidative stress
WG74_RS09230	COG2030	dehydratase
WG74_RS09240	COG0739	heme binding
WG74_RS09240	COG1196	nuclear chromosome segregation
WG74_RS09240	COG0741	lytic transglycosylase activity
WG74_RS09255	COG3451	type IV secretory pathway VirB4
WG74_RS09275	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WG74_RS09280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WG74_RS09285	COG0248	Ppx GppA phosphatase
WG74_RS09305	COG3264	Mechanosensitive ion channel
WG74_RS09305	COG1511	domain protein
WG74_RS09310	COG0346	lactoylglutathione lyase activity
WG74_RS09325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WG74_RS09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
WG74_RS09330	COG0022	dehydrogenase e1 component
WG74_RS09360	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
WG74_RS09370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WG74_RS09385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WG74_RS09390	COG2867	negative regulation of translational initiation
WG74_RS09395	COG1546	Belongs to the CinA family
WG74_RS09395	COG1058	Belongs to the CinA family
WG74_RS09400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WG74_RS09400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WG74_RS09410	COG5000	phosphorelay sensor kinase activity
WG74_RS09415	COG2204	response regulator
WG74_RS09420	COG1923	regulation of RNA biosynthetic process
WG74_RS09425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WG74_RS09430	COG3956	TIGRFAM MazG family protein
WG74_RS09435	COG2814	Major facilitator Superfamily
WG74_RS09445	COG0084	hydrolase, TatD family'
WG74_RS09455	COG0470	DNA polymerase III
WG74_RS09460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WG74_RS09465	COG1686	Belongs to the peptidase S11 family
WG74_RS09475	COG2951	lytic endotransglycosylase activity
WG74_RS09490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WG74_RS09505	COG0508	dehydrogenase complex catalyzes the overall conversion of
WG74_RS09520	COG0557	exoribonuclease II activity
WG74_RS09530	COG0442	prolyl-tRNA aminoacylation
WG74_RS09545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WG74_RS09550	COG0477	Major facilitator Superfamily
WG74_RS09570	COG1752	Esterase of the alpha-beta hydrolase superfamily
WG74_RS09575	COG0484	heat shock protein binding
WG74_RS09580	COG0443	Heat shock 70 kDa protein
WG74_RS09610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WG74_RS09615	COG1420	regulation of RNA biosynthetic process
WG74_RS09625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WG74_RS09630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WG74_RS09635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WG74_RS09640	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WG74_RS09645	COG0586	Pfam SNARE associated Golgi protein
WG74_RS09655	COG0189	ligase activity
WG74_RS09660	COG0792	nuclease activity
WG74_RS09665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WG74_RS09675	COG0187	DNA topoisomerase II activity
WG74_RS09680	COG2852	Protein conserved in bacteria
WG74_RS09705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WG74_RS09730	COG3739	integral membrane protein
WG74_RS09745	COG3876	Protein conserved in bacteria
WG74_RS09755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WG74_RS09770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WG74_RS09780	COG1960	acyl-CoA dehydrogenase activity
WG74_RS09785	COG0789	Transcriptional regulator
WG74_RS09790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WG74_RS09795	COG1040	competence protein
WG74_RS09805	COG0574	Belongs to the PEP-utilizing enzyme family
WG74_RS09805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WG74_RS09810	COG0751	glycine-tRNA ligase activity
WG74_RS09815	COG0752	glycyl-tRNA synthetase alpha subunit
WG74_RS09850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WG74_RS09855	COG0193	aminoacyl-tRNA hydrolase activity
WG74_RS09870	COG0012	GTP binding
WG74_RS09890	COG2030	dehydratase
WG74_RS09890	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS09900	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WG74_RS09920	COG0768	penicillin binding
WG74_RS09925	COG0772	Belongs to the SEDS family
WG74_RS09950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WG74_RS09960	COG3590	peptidase
WG74_RS09965	COG0148	phosphopyruvate hydratase activity
WG74_RS10000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WG74_RS10020	COG0505	Belongs to the CarA family
WG74_RS10035	COG0358	DNA primase activity
WG74_RS10040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WG74_RS10055	COG0698	ribose 5-phosphate isomerase
WG74_RS10060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WG74_RS10090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WG74_RS10095	COG5001	Diguanylate cyclase
WG74_RS10095	COG3300	MHYT domain
WG74_RS10105	COG0343	queuine tRNA-ribosyltransferase activity
WG74_RS10120	COG0842	Transport permease protein
WG74_RS10125	COG1131	(ABC) transporter
WG74_RS10130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WG74_RS10140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WG74_RS10145	COG0142	geranyltranstransferase activity
WG74_RS10150	COG1722	exodeoxyribonuclease VII activity
WG74_RS10160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WG74_RS10190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WG74_RS10195	COG3618	amidohydrolase
WG74_RS10215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WG74_RS10225	COG5002	protein histidine kinase activity
WG74_RS10230	COG0573	inorganic phosphate transmembrane transporter activity
WG74_RS10240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WG74_RS10245	COG0704	Plays a role in the regulation of phosphate uptake
WG74_RS10250	COG0745	RESPONSE REGULATOR receiver
WG74_RS10280	COG3338	carbonate dehydratase activity
WG74_RS10310	COG0531	amino acid
WG74_RS10315	COG0733	neurotransmitter:sodium symporter activity
WG74_RS10320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WG74_RS10330	COG2204	response regulator
WG74_RS10340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WG74_RS10385	COG0483	inositol monophosphate 1-phosphatase activity
WG74_RS10395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WG74_RS10410	COG0352	thiamine-phosphate diphosphorylase activity
WG74_RS10420	COG3588	fructose-bisphosphate aldolase
WG74_RS10435	COG0126	phosphoglycerate kinase activity
WG74_RS10440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WG74_RS10460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WG74_RS10470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WG74_RS10495	COG0022	dehydrogenase e1 component
WG74_RS10505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WG74_RS10520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WG74_RS10530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WG74_RS10535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WG74_RS10545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WG74_RS10555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WG74_RS10580	COG0653	protein targeting
WG74_RS10595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WG74_RS10600	COG0483	inositol monophosphate 1-phosphatase activity
WG74_RS10610	COG1074	ATP-dependent DNA helicase activity
WG74_RS10620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WG74_RS10625	COG3178	'Phosphotransferase
WG74_RS10630	COG0802	atpase or kinase
WG74_RS10635	COG2205	protein histidine kinase activity
WG74_RS10640	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WG74_RS10645	COG0678	peroxiredoxin activity
WG74_RS10655	COG1309	transcriptional regulator
WG74_RS10660	COG0302	gtp cyclohydrolase
WG74_RS10665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WG74_RS10670	COG4771	TonB-dependent receptor
WG74_RS10685	COG2197	response regulator
WG74_RS10705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WG74_RS10710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WG74_RS10715	COG0071	Belongs to the small heat shock protein (HSP20) family
WG74_RS10720	COG0504	CTP synthase activity
WG74_RS10730	COG0149	triose-phosphate isomerase activity
WG74_RS10735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WG74_RS10740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WG74_RS10765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WG74_RS10770	COG0134	indole-3-glycerol-phosphate synthase activity
WG74_RS10775	COG0315	cyclic pyranopterin monophosphate synthase activity
WG74_RS10780	COG0303	'Molybdopterin
WG74_RS10785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WG74_RS10790	COG0658	competence protein
WG74_RS10790	COG2333	competence protein COMEC
WG74_RS10795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WG74_RS10805	COG2205	protein histidine kinase activity
WG74_RS10835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WG74_RS10845	COG1007	ATP synthesis coupled electron transport
WG74_RS10860	COG0713	ATP synthesis coupled electron transport
WG74_RS10870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WG74_RS10880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WG74_RS10885	COG1034	ATP synthesis coupled electron transport
WG74_RS10920	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WG74_RS10925	COG0649	NAD binding
WG74_RS10935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WG74_RS10940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WG74_RS10945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WG74_RS10950	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS10955	COG0183	Belongs to the thiolase family
WG74_RS10970	COG0004	ammonium transporteR
WG74_RS10995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WG74_RS11005	COG1530	ribonuclease E activity
WG74_RS11030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WG74_RS11035	COG1024	Enoyl-CoA hydratase
WG74_RS11035	COG1250	3-hydroxyacyl-CoA dehydrogenase
WG74_RS11040	COG0367	asparagine synthase
WG74_RS11065	COG3267	Type II secretory pathway component ExeA
WG74_RS11065	COG3409	Peptidoglycan-binding domain 1 protein
WG74_RS11095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WG74_RS11120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WG74_RS11125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WG74_RS11125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WG74_RS11140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WG74_RS11165	COG0521	Mo-molybdopterin cofactor biosynthetic process
WG74_RS11170	COG0530	calcium, potassium:sodium antiporter activity
WG74_RS11200	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS11220	COG1136	(ABC) transporter
WG74_RS11225	COG4591	ABC-type transport system involved in lipoprotein release permease component
WG74_RS11230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WG74_RS11235	COG4221	oxidoreductase activity
WG74_RS11250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WG74_RS11255	COG0415	Belongs to the DNA photolyase family
WG74_RS11260	COG0671	phosphoesterase, PA-phosphatase related
WG74_RS11265	COG1013	pyruvate-flavodoxin oxidoreductase activity
WG74_RS11270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WG74_RS11270	COG0674	pyruvate-flavodoxin oxidoreductase activity
WG74_RS11275	COG0657	acetylesterase activity
WG74_RS11280	COG1051	belongs to the nudix hydrolase family
WG74_RS11290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WG74_RS11290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WG74_RS11305	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WG74_RS11310	COG1842	Phage shock protein A
WG74_RS11350	COG2166	iron-sulfur cluster assembly
WG74_RS11375	COG0824	Thioesterase
WG74_RS11400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WG74_RS11435	COG0825	malonyl-CoA metabolic process
WG74_RS11440	COG4974	Belongs to the 'phage' integrase family
WG74_RS11450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WG74_RS11455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WG74_RS11460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WG74_RS11460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WG74_RS11465	COG4770	biotin carboxylase activity
WG74_RS11485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WG74_RS11495	COG2873	o-acetylhomoserine
WG74_RS11500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WG74_RS11500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WG74_RS11510	COG0346	lactoylglutathione lyase activity
WG74_RS11520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WG74_RS11535	COG0513	Belongs to the DEAD box helicase family
WG74_RS11545	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
WG74_RS11550	COG1285	pathogenesis
WG74_RS11560	COG0166	Belongs to the GPI family
WG74_RS11565	COG0681	Belongs to the peptidase S26 family
WG74_RS11570	COG0571	ribonuclease III activity
WG74_RS11575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WG74_RS11600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WG74_RS11600	COG1754	DNA topoisomerase type I activity
WG74_RS11615	COG0758	DNA mediated transformation
WG74_RS11620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WG74_RS11630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WG74_RS11635	COG0156	8-amino-7-oxononanoate synthase activity
WG74_RS11695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
WG74_RS11740	COG1024	Enoyl-CoA hydratase
WG74_RS11765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WG74_RS11785	COG0347	Belongs to the P(II) protein family
WG74_RS11790	COG0004	ammonium transporteR
WG74_RS11845	COG3002	Belongs to the UPF0753 family
WG74_RS11850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WG74_RS11870	COG4774	siderophore transport
WG74_RS11880	COG4771	TonB-dependent receptor
WG74_RS11890	COG4638	Rieske (2fe-2S)
WG74_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS11925	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
WG74_RS11935	COG1024	Enoyl-CoA hydratase
WG74_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS11955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WG74_RS11990	COG0066	3-isopropylmalate dehydratase activity
WG74_RS11995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WG74_RS12005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WG74_RS12020	COG2124	cytochrome p450
WG74_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS12040	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS12050	COG4771	TonB-dependent receptor
WG74_RS12065	COG4770	biotin carboxylase activity
WG74_RS12070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WG74_RS12070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WG74_RS12075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WG74_RS12135	COG0681	Belongs to the peptidase S26 family
WG74_RS12275	COG0629	single-stranded DNA binding
WG74_RS12295	COG4227	nucleotidyltransferase activity
WG74_RS12300	COG2132	Multicopper oxidase
WG74_RS12315	COG0516	GMP reductase activity
WG74_RS12315	COG0517	IMP dehydrogenase activity
WG74_RS12345	COG0789	Transcriptional regulator
WG74_RS12355	COG0672	)-iron permease
WG74_RS12380	COG0741	lytic transglycosylase activity
WG74_RS12385	COG0582	viral genome integration into host DNA
WG74_RS12400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WG74_RS12405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WG74_RS12410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WG74_RS12425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WG74_RS12430	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WG74_RS12435	COG0583	DNA-binding transcription factor activity
WG74_RS12440	COG1192	Involved in chromosome partitioning
WG74_RS12450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WG74_RS12465	COG0028	Belongs to the TPP enzyme family
WG74_RS12480	COG5001	Diguanylate cyclase
WG74_RS12480	COG3300	MHYT domain
WG74_RS12485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WG74_RS12490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WG74_RS12495	COG0552	protein localization to endoplasmic reticulum
WG74_RS12500	COG2917	probably involved in intracellular septation
WG74_RS12510	COG3158	transport of potassium into the cell
WG74_RS12520	COG3088	subunit of a heme lyase
WG74_RS12525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WG74_RS12530	COG1138	Cytochrome C-type biogenesis protein
WG74_RS12535	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WG74_RS12540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WG74_RS12565	COG0254	rRNA binding
WG74_RS12570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WG74_RS12585	COG0750	zinc metalloprotease
WG74_RS12590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WG74_RS12600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WG74_RS12605	COG0233	cytoplasmic translational termination
WG74_RS12610	COG0528	UMP kinase activity
WG74_RS12615	COG1408	metallophosphoesterase
WG74_RS12625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WG74_RS12630	COG0052	Belongs to the universal ribosomal protein uS2 family
WG74_RS12640	COG0688	phosphatidylethanolamine metabolic process
WG74_RS12655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WG74_RS12660	COG0776	regulation of translation
WG74_RS12670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WG74_RS12700	COG1643	Atp-dependent helicase
WG74_RS12715	COG0142	geranyltranstransferase activity
WG74_RS12750	COG0488	(ABC) transporter
WG74_RS12755	COG1573	uracil-dna glycosylase
WG74_RS12770	COG0438	transferase activity, transferring glycosyl groups
WG74_RS12775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WG74_RS12780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WG74_RS12785	COG1862	Preprotein translocase
WG74_RS12795	COG0612	Peptidase, M16
WG74_RS12825	COG1960	acyl-CoA dehydrogenase activity
WG74_RS12830	COG1960	acyl-CoA dehydrogenase activity
WG74_RS12835	COG4566	intracellular signal transduction
WG74_RS12865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WG74_RS12870	COG1845	cytochrome c oxidase, subunit III
WG74_RS12875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WG74_RS12880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WG74_RS12890	COG0028	Belongs to the TPP enzyme family
WG74_RS12900	COG0668	transmembrane transport
WG74_RS12905	COG0069	glutamate synthase activity
WG74_RS12910	COG1960	acyl-CoA dehydrogenase activity
WG74_RS12915	COG2211	Major facilitator Superfamily
WG74_RS12920	COG2211	Major facilitator Superfamily
WG74_RS12925	COG1960	acyl-CoA dehydrogenase activity
WG74_RS12930	COG1960	acyl-CoA dehydrogenase activity
WG74_RS12945	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS12950	COG0183	Belongs to the thiolase family
WG74_RS12960	COG1024	Enoyl-CoA hydratase
WG74_RS12960	COG1250	3-hydroxyacyl-CoA dehydrogenase
WG74_RS12965	COG2272	Belongs to the type-B carboxylesterase lipase family
WG74_RS12970	COG4206	TonB-dependent receptor
WG74_RS12975	COG2272	Belongs to the type-B carboxylesterase lipase family
WG74_RS13010	COG2272	Belongs to the type-B carboxylesterase lipase family
WG74_RS13025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WG74_RS13035	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS13055	COG0642	Histidine kinase
WG74_RS13070	COG0842	Transport permease protein
WG74_RS13100	COG1185	polyribonucleotide nucleotidyltransferase activity
WG74_RS13105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WG74_RS13110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WG74_RS13120	COG1994	Peptidase M50
WG74_RS13125	COG1435	thymidine kinase activity
WG74_RS13130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WG74_RS13140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WG74_RS13155	COG0779	Required for maturation of 30S ribosomal subunits
WG74_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS13170	COG2321	neutral zinc metallopeptidase
WG74_RS13180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WG74_RS13205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WG74_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS13230	COG2264	protein methyltransferase activity
WG74_RS13245	COG4941	Belongs to the sigma-70 factor family
WG74_RS13250	COG3795	YCII-related domain
WG74_RS13260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WG74_RS13275	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WG74_RS13280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WG74_RS13290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WG74_RS13295	COG0753	catalase activity
WG74_RS13305	COG2132	Multicopper oxidase
WG74_RS13320	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WG74_RS13325	COG0481	GTPase activity
WG74_RS13330	COG5001	Diguanylate cyclase
WG74_RS13360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WG74_RS13370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WG74_RS13380	COG2354	Protein conserved in bacteria
WG74_RS13385	COG0360	Binds together with S18 to 16S ribosomal RNA
WG74_RS13390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WG74_RS13395	COG0359	binds to the 23S rRNA
WG74_RS13400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WG74_RS13415	COG0189	ligase activity
WG74_RS13420	COG4067	protein conserved in archaea
WG74_RS13420	COG0189	ligase activity
WG74_RS13445	COG1566	PFAM secretion protein HlyD family protein
WG74_RS13450	COG2814	Major facilitator Superfamily
WG74_RS13470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WG74_RS13485	COG0335	large ribosomal subunit rRNA binding
WG74_RS13490	COG0336	Belongs to the RNA methyltransferase TrmD family
WG74_RS13525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WG74_RS13530	COG0228	four-way junction DNA binding
WG74_RS13535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WG74_RS13550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WG74_RS13570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WG74_RS13575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WG74_RS13580	COG0539	negative regulation of cytoplasmic translation
WG74_RS13595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WG74_RS13600	COG0454	-acetyltransferase
WG74_RS13605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WG74_RS13615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WG74_RS13620	COG0356	it plays a direct role in the translocation of protons across the membrane
WG74_RS13645	COG2003	Belongs to the UPF0758 family
WG74_RS13655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WG74_RS13665	COG0284	orotidine-5'-phosphate decarboxylase activity
WG74_RS13680	COG0135	phosphoribosylanthranilate isomerase activity
WG74_RS13690	COG0133	tryptophan synthase activity
WG74_RS13695	COG2852	Protein conserved in bacteria
WG74_RS13710	COG0159	tryptophan synthase activity
WG74_RS13715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WG74_RS13720	COG0285	dihydrofolate synthase activity
WG74_RS13725	COG2223	nitrite transmembrane transporter activity
WG74_RS13730	COG1187	pseudouridine synthase activity
WG74_RS13735	COG0742	ribosomal rna small subunit methyltransferase
WG74_RS13750	COG0210	DNA helicase
WG74_RS13755	COG3300	MHYT domain
WG74_RS13755	COG5001	Diguanylate cyclase
WG74_RS13795	COG0538	isocitrate dehydrogenase activity
WG74_RS13800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WG74_RS13805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WG74_RS13805	COG3153	acetyltransferase
WG74_RS13820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WG74_RS13825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WG74_RS13840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WG74_RS13860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WG74_RS13865	COG0741	lytic transglycosylase activity
WG74_RS13885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WG74_RS13890	COG2258	MOSC domain
WG74_RS13915	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
WG74_RS13920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WG74_RS13930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WG74_RS13940	COG0137	argininosuccinate synthase activity
WG74_RS13945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WG74_RS13975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WG74_RS13990	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WG74_RS14010	COG0339	signal peptide processing
WG74_RS14020	COG1120	ATPase activity
WG74_RS14055	COG5001	Diguanylate cyclase
WG74_RS14060	COG0039	L-malate dehydrogenase activity
WG74_RS14065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WG74_RS14075	COG0508	dehydrogenase complex catalyzes the overall conversion of
WG74_RS14080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WG74_RS14100	COG2860	membrane
WG74_RS14115	COG1505	serine-type exopeptidase activity
WG74_RS14135	COG0203	ribosomal protein L17
WG74_RS14140	COG0202	RNA polymerase activity
WG74_RS14145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WG74_RS14150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WG74_RS14160	COG0563	adenylate kinase activity
WG74_RS14165	COG0201	protein transport
WG74_RS14170	COG0200	Binds to the 23S rRNA
WG74_RS14175	COG1841	ribosomal large subunit assembly
WG74_RS14180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WG74_RS14185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WG74_RS14190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WG74_RS14195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WG74_RS14200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WG74_RS14205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WG74_RS14210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WG74_RS14215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WG74_RS14220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WG74_RS14225	COG0255	Belongs to the universal ribosomal protein uL29 family
WG74_RS14230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WG74_RS14235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WG74_RS14240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WG74_RS14245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WG74_RS14250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WG74_RS14255	COG0089	rRNA binding
WG74_RS14260	COG0088	Forms part of the polypeptide exit tunnel
WG74_RS14265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WG74_RS14270	COG0051	transcription antitermination factor activity, RNA binding
WG74_RS14275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WG74_RS14280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WG74_RS14285	COG0049	tRNA binding
WG74_RS14290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WG74_RS14300	COG1396	sequence-specific DNA binding
WG74_RS14315	COG4206	TonB-dependent receptor
WG74_RS14330	COG0583	DNA-binding transcription factor activity
WG74_RS14335	COG0612	Peptidase, M16
WG74_RS14340	COG2967	ApaG domain
WG74_RS14345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WG74_RS14375	COG1381	Involved in DNA repair and RecF pathway recombination
WG74_RS14395	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WG74_RS14405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WG74_RS14445	COG0625	glutathione transferase activity
WG74_RS14450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WG74_RS14460	COG0488	(ABC) transporter
WG74_RS14465	COG0514	ATP-dependent DNA helicase (RecQ)
WG74_RS14495	COG0745	RESPONSE REGULATOR receiver
WG74_RS14540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WG74_RS14545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WG74_RS14555	COG1719	4-vinyl reductase, 4VR
WG74_RS14560	COG1032	radical SAM domain protein
WG74_RS14620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WG74_RS14625	COG3047	cAMP biosynthetic process
WG74_RS14635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WG74_RS14645	COG1741	Belongs to the pirin family
WG74_RS14650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WG74_RS14655	COG3577	Aspartyl protease
WG74_RS14660	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
WG74_RS14665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WG74_RS14670	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WG74_RS14675	COG0612	Peptidase, M16
WG74_RS14680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WG74_RS14685	COG0778	Nitroreductase
WG74_RS14695	COG0456	acetyltransferase
WG74_RS14700	COG4957	zinc ion binding
WG74_RS14720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WG74_RS14765	COG3706	GGDEF domain
WG74_RS14770	COG3920	Histidine kinase
WG74_RS14770	COG2202	Pas domain
WG74_RS14785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WG74_RS14790	COG1253	flavin adenine dinucleotide binding
WG74_RS14795	COG0583	DNA-binding transcription factor activity
WG74_RS14805	COG2239	Acts as a magnesium transporter
WG74_RS14880	COG1194	a g-specific adenine glycosylase
WG74_RS14900	COG1196	nuclear chromosome segregation
WG74_RS14910	COG1522	sequence-specific DNA binding
WG74_RS14920	COG0776	regulation of translation
WG74_RS14925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WG74_RS14930	COG0416	fatty acid biosynthetic process
WG74_RS14935	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WG74_RS14945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WG74_RS14980	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS14995	COG0215	cysteine-tRNA ligase activity
WG74_RS15045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WG74_RS15070	COG3046	protein related to deoxyribodipyrimidine photolyase
WG74_RS15075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WG74_RS15080	COG2375	cellular response to nickel ion
WG74_RS15085	COG1012	belongs to the aldehyde dehydrogenase family
WG74_RS15110	COG2169	Transcriptional regulator
WG74_RS15110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WG74_RS15120	COG2175	clavaminate synthase activity
WG74_RS15125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WG74_RS15130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WG74_RS15135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WG74_RS15145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WG74_RS15155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WG74_RS15175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WG74_RS15180	COG0546	phosphoglycolate phosphatase activity
WG74_RS15185	COG1505	serine-type exopeptidase activity
WG74_RS15190	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS15210	COG1045	serine acetyltransferase
WG74_RS15225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WG74_RS15230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WG74_RS15235	COG0105	UTP biosynthetic process
WG74_RS15245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WG74_RS15255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WG74_RS15260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WG74_RS15265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WG74_RS15270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WG74_RS15280	COG3724	N-succinylarginine dihydrolase activity
WG74_RS15295	COG1970	mechanosensitive ion channel activity
WG74_RS15305	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WG74_RS15330	COG1983	PspC domain protein
WG74_RS15335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WG74_RS15345	COG4771	TonB-dependent receptor
WG74_RS15370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WG74_RS15385	COG0640	Transcriptional regulator
WG74_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
WG74_RS15410	COG0596	Alpha beta hydrolase
WG74_RS15410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WG74_RS15410	COG2226	methyltransferase
WG74_RS15425	COG0556	nucleotide-excision repair
WG74_RS15450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WG74_RS15465	COG0181	hydroxymethylbilane synthase activity
WG74_RS15470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WG74_RS15475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WG74_RS15485	COG2304	oxidoreductase activity
WG74_RS15505	COG1960	acyl-CoA dehydrogenase activity
WG74_RS15535	COG1546	Belongs to the CinA family
WG74_RS15535	COG1058	Belongs to the CinA family
WG74_RS15550	COG0081	regulation of translation
WG74_RS15555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WG74_RS15575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WG74_RS15580	COG1115	amino acid carrier protein
WG74_RS15585	COG0346	lactoylglutathione lyase activity
WG74_RS15595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WG74_RS15620	COG0318	PFAM AMP-dependent synthetase and ligase
WG74_RS15670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WG74_RS15680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WG74_RS15685	COG3387	PFAM Glycoside hydrolase 15-related
WG74_RS15745	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
WG74_RS15750	COG4786	Flagellar basal body rod
WG74_RS15760	COG4786	Flagellar basal body rod
WG74_RS15765	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WG74_RS15770	COG1706	bacterial-type flagellum-dependent cell motility
WG74_RS15780	COG1256	bacterial-type flagellum assembly
WG74_RS15780	COG4786	Flagellar basal body rod
WG74_RS15785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WG74_RS15795	COG1360	Flagellar Motor Protein
WG74_RS15800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WG74_RS15810	COG1677	Flagellar hook-basal body complex protein FliE
WG74_RS15820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation