locus-tag	class	description
AES38_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AES38_RS00010	COG0592	DNA-directed DNA polymerase activity
AES38_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AES38_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AES38_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AES38_RS00030	COG0187	DNA topoisomerase II activity
AES38_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AES38_RS00075	COG3764	Sortase (surface protein transpeptidase)
AES38_RS00090	COG0515	serine threonine protein kinase
AES38_RS00095	COG0768	penicillin binding
AES38_RS00110	COG1716	ATPase activity
AES38_RS00125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AES38_RS00125	COG2755	lipolytic protein G-D-S-L family
AES38_RS00130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AES38_RS00135	COG2197	response regulator
AES38_RS00140	COG4585	Histidine kinase
AES38_RS00145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AES38_RS00155	COG0514	ATP-dependent DNA helicase (RecQ)
AES38_RS00155	COG0514	ATP-dependent DNA helicase (RecQ)
AES38_RS00160	COG2066	Belongs to the glutaminase family
AES38_RS00180	COG0673	inositol 2-dehydrogenase activity
AES38_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS00260	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AES38_RS00335	COG0443	Heat shock 70 kDa protein
AES38_RS00340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AES38_RS00345	COG0484	heat shock protein binding
AES38_RS00350	COG0789	Transcriptional regulator
AES38_RS00355	COG2813	Specifically methylates the guanine in position
AES38_RS00365	COG3655	Transcriptional regulator
AES38_RS00380	COG0659	secondary active sulfate transmembrane transporter activity
AES38_RS00400	COG3858	chitin binding
AES38_RS00415	COG1120	ATPase activity
AES38_RS00460	COG0583	DNA-binding transcription factor activity
AES38_RS00465	COG1012	belongs to the aldehyde dehydrogenase family
AES38_RS00475	COG1309	transcriptional regulator
AES38_RS00480	COG0477	Major facilitator Superfamily
AES38_RS00500	COG1653	transport
AES38_RS00505	COG1175	transmembrane transport
AES38_RS00510	COG0395	ABC-type sugar transport system, permease component
AES38_RS00515	COG3250	beta-galactosidase activity
AES38_RS00525	COG0673	inositol 2-dehydrogenase activity
AES38_RS00530	COG0395	ABC-type sugar transport system, permease component
AES38_RS00545	COG1846	Transcriptional regulator
AES38_RS00545	COG1940	carbohydrate kinase activity
AES38_RS00550	COG2409	Drug exporters of the RND superfamily
AES38_RS00570	COG2828	Protein conserved in bacteria
AES38_RS00575	COG0583	DNA-binding transcription factor activity
AES38_RS00585	COG1280	lysine exporter protein (LysE YggA)
AES38_RS00590	COG1250	3-hydroxyacyl-CoA dehydrogenase
AES38_RS00600	COG0671	phosphoesterase, PA-phosphatase related
AES38_RS00615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AES38_RS00635	COG3321	synthase
AES38_RS00635	COG0604	alcohol dehydrogenase
AES38_RS00680	COG1396	sequence-specific DNA binding
AES38_RS00690	COG1335	isochorismatase
AES38_RS00715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AES38_RS00725	COG3458	cephalosporin-C deacetylase activity
AES38_RS00730	COG3226	Transcriptional regulator
AES38_RS00740	COG4172	Belongs to the ABC transporter superfamily
AES38_RS00745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AES38_RS00750	COG0601	transmembrane transport
AES38_RS00755	COG0747	negative chemotaxis
AES38_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS00800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AES38_RS00800	COG2169	Transcriptional regulator
AES38_RS00805	COG1595	DNA-templated transcription, initiation
AES38_RS00810	COG0745	RESPONSE REGULATOR receiver
AES38_RS00820	COG0604	alcohol dehydrogenase
AES38_RS00825	COG1846	Transcriptional regulator
AES38_RS00830	COG0673	inositol 2-dehydrogenase activity
AES38_RS00850	COG1609	Transcriptional regulator
AES38_RS00885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AES38_RS00890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AES38_RS00900	COG0494	nUDIX hydrolase
AES38_RS00910	COG2197	response regulator
AES38_RS00915	COG4585	Histidine kinase
AES38_RS00930	COG1175	transmembrane transport
AES38_RS00935	COG0395	ABC-type sugar transport system, permease component
AES38_RS00945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AES38_RS00955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AES38_RS00985	COG1609	Transcriptional regulator
AES38_RS01000	COG1175	transmembrane transport
AES38_RS01005	COG0395	ABC-type sugar transport system, permease component
AES38_RS01025	COG0563	adenylate kinase activity
AES38_RS01075	COG1653	transport
AES38_RS01080	COG1175	transmembrane transport
AES38_RS01085	COG0395	ABC-type sugar transport system, permease component
AES38_RS01090	COG1472	Belongs to the glycosyl hydrolase 3 family
AES38_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS01135	COG1522	sequence-specific DNA binding
AES38_RS01145	COG3534	alpha-L-arabinofuranosidase
AES38_RS01180	COG1121	(ABC) transporter
AES38_RS01215	COG3634	alkyl hydroperoxide reductase activity
AES38_RS01220	COG0542	response to heat
AES38_RS01235	COG0667	Aldo Keto reductase
AES38_RS01265	COG3409	Peptidoglycan-binding domain 1 protein
AES38_RS01355	COG1486	melibiose metabolic process
AES38_RS01360	COG1349	DNA-binding transcription factor activity
AES38_RS01385	COG0363	glucosamine-6-phosphate deaminase activity
AES38_RS01405	COG1175	transmembrane transport
AES38_RS01415	COG1609	Transcriptional regulator
AES38_RS01430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AES38_RS01435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AES38_RS01450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AES38_RS01485	COG0494	nUDIX hydrolase
AES38_RS01520	COG1668	transmembrane transport
AES38_RS01525	COG4152	abc transporter atp-binding protein
AES38_RS01535	COG3386	PFAM SMP-30 Gluconolaconase
AES38_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS01545	COG4221	oxidoreductase activity
AES38_RS01550	COG2197	response regulator
AES38_RS01555	COG4585	Histidine kinase
AES38_RS01560	COG0477	Major facilitator Superfamily
AES38_RS01565	COG2267	carboxylic ester hydrolase activity
AES38_RS01580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AES38_RS01590	COG4221	oxidoreductase activity
AES38_RS01595	COG0789	Transcriptional regulator
AES38_RS01605	COG1846	Transcriptional regulator
AES38_RS01610	COG1764	response to oxidative stress
AES38_RS01640	COG3546	catalase activity
AES38_RS01650	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AES38_RS01675	COG3479	Phenolic acid decarboxylase
AES38_RS01745	COG2267	carboxylic ester hydrolase activity
AES38_RS01815	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS01825	COG5002	protein histidine kinase activity
AES38_RS01860	COG1595	DNA-templated transcription, initiation
AES38_RS01870	COG2084	Dehydrogenase
AES38_RS01875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AES38_RS01890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AES38_RS01895	COG3237	CsbD-like
AES38_RS01905	COG0514	ATP-dependent DNA helicase (RecQ)
AES38_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS01945	COG1819	glycosyl
AES38_RS01960	COG1305	Transglutaminase-like
AES38_RS01965	COG2267	carboxylic ester hydrolase activity
AES38_RS02010	COG0456	acetyltransferase
AES38_RS02010	COG3153	acetyltransferase
AES38_RS02025	COG0033	Phosphoglucomutase
AES38_RS02030	COG0077	Prephenate dehydratase
AES38_RS02040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AES38_RS02050	COG1063	alcohol dehydrogenase
AES38_RS02060	COG1316	TRANSCRIPTIONal
AES38_RS02080	COG0673	inositol 2-dehydrogenase activity
AES38_RS02120	COG0706	membrane insertase activity
AES38_RS02135	COG0667	Aldo Keto reductase
AES38_RS02145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AES38_RS02155	COG0415	Belongs to the DNA photolyase family
AES38_RS02170	COG0745	RESPONSE REGULATOR receiver
AES38_RS02175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AES38_RS02195	COG0569	domain protein
AES38_RS02200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AES38_RS02230	COG1609	Transcriptional regulator
AES38_RS02275	COG0017	Asparaginyl-tRNA synthetase
AES38_RS02280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AES38_RS02285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AES38_RS02290	COG1984	allophanate hydrolase subunit 2
AES38_RS02310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AES38_RS02315	COG0406	alpha-ribazole phosphatase activity
AES38_RS02320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AES38_RS02325	COG0785	Cytochrome C biogenesis protein
AES38_RS02335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AES38_RS02340	COG4948	Mandelate Racemase Muconate Lactonizing
AES38_RS02345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AES38_RS02365	COG0494	nUDIX hydrolase
AES38_RS02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AES38_RS02380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AES38_RS02385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AES38_RS02420	COG3253	May function as heme-dependent peroxidase
AES38_RS02425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AES38_RS02430	COG0181	hydroxymethylbilane synthase activity
AES38_RS02440	COG0113	porphobilinogen synthase activity
AES38_RS02445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AES38_RS02450	COG1864	DNA RNA non-specific endonuclease
AES38_RS02450	COG3591	Belongs to the peptidase S1B family
AES38_RS02455	COG5398	heme oxygenase
AES38_RS02465	COG0604	alcohol dehydrogenase
AES38_RS02475	COG1940	carbohydrate kinase activity
AES38_RS02480	COG1879	ABC-type sugar transport system periplasmic component
AES38_RS02485	COG1172	Belongs to the binding-protein-dependent transport system permease family
AES38_RS02495	COG1082	Xylose isomerase domain protein TIM barrel
AES38_RS02505	COG1072	(Pantothenic acid kinase))
AES38_RS02520	COG2017	converts alpha-aldose to the beta-anomer
AES38_RS02530	COG1846	Transcriptional regulator
AES38_RS02570	COG0454	-acetyltransferase
AES38_RS02570	COG0456	acetyltransferase
AES38_RS02600	COG1725	Transcriptional regulator
AES38_RS02625	COG1834	amidinotransferase
AES38_RS02630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AES38_RS02645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AES38_RS02655	COG4149	molybdate abc transporter
AES38_RS02660	COG1840	ABC-type Fe3 transport system, periplasmic component
AES38_RS02665	COG1609	Transcriptional regulator
AES38_RS02680	COG3135	benzoate transporter
AES38_RS02710	COG1902	pentaerythritol trinitrate reductase activity
AES38_RS02715	COG2197	response regulator
AES38_RS02720	COG4585	Histidine kinase
AES38_RS02730	COG1309	transcriptional regulator
AES38_RS02775	COG1045	serine acetyltransferase
AES38_RS02785	COG1846	Transcriptional regulator
AES38_RS02790	COG0697	spore germination
AES38_RS02795	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AES38_RS02810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AES38_RS02830	COG0488	(ABC) transporter
AES38_RS02835	COG0366	Alpha amylase catalytic
AES38_RS02840	COG1064	alcohol dehydrogenase
AES38_RS02890	COG5434	Belongs to the glycosyl hydrolase 28 family
AES38_RS02920	COG0419	ATPase involved in DNA repair
AES38_RS02925	COG0420	3'-5' exonuclease activity
AES38_RS02930	COG0300	oxidoreductase activity
AES38_RS02940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AES38_RS02975	COG2205	protein histidine kinase activity
AES38_RS02980	COG0745	RESPONSE REGULATOR receiver
AES38_RS03010	COG2197	response regulator
AES38_RS03015	COG1764	response to oxidative stress
AES38_RS03020	COG1605	Chorismate mutase
AES38_RS03020	COG0287	Prephenate dehydrogenase
AES38_RS03080	COG0489	protein tyrosine kinase activity
AES38_RS03085	COG2755	lipolytic protein G-D-S-L family
AES38_RS03085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AES38_RS03110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AES38_RS03115	COG0047	phosphoribosylformylglycinamidine synthase activity
AES38_RS03120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AES38_RS03145	COG0667	Aldo Keto reductase
AES38_RS03185	COG1253	flavin adenine dinucleotide binding
AES38_RS03200	COG0500	methyltransferase
AES38_RS03210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AES38_RS03215	COG0151	Belongs to the GarS family
AES38_RS03235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AES38_RS03265	COG0531	amino acid
AES38_RS03275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AES38_RS03360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AES38_RS03365	COG0513	Belongs to the DEAD box helicase family
AES38_RS03380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AES38_RS03395	COG3718	enzyme involved in inositol metabolism
AES38_RS03400	COG3962	Belongs to the TPP enzyme family
AES38_RS03415	COG1250	3-hydroxyacyl-CoA dehydrogenase
AES38_RS03450	COG2226	methyltransferase
AES38_RS03450	COG1073	alpha beta
AES38_RS03470	COG0149	triose-phosphate isomerase activity
AES38_RS03475	COG0698	ribose 5-phosphate isomerase
AES38_RS03480	COG2376	Dihydroxyacetone kinase
AES38_RS03490	COG2188	Transcriptional regulator
AES38_RS03510	COG0673	inositol 2-dehydrogenase activity
AES38_RS03525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AES38_RS03530	COG0514	ATP-dependent DNA helicase (RecQ)
AES38_RS03540	COG4166	transmembrane transport
AES38_RS03545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AES38_RS03555	COG0444	Belongs to the ABC transporter superfamily
AES38_RS03570	COG0006	proline dipeptidase activity
AES38_RS03595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AES38_RS03600	COG3938	Belongs to the proline racemase family
AES38_RS03640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AES38_RS03655	COG0438	transferase activity, transferring glycosyl groups
AES38_RS03670	COG0489	protein tyrosine kinase activity
AES38_RS03685	COG0438	transferase activity, transferring glycosyl groups
AES38_RS03690	COG2244	polysaccharide biosynthetic process
AES38_RS03720	COG3387	PFAM Glycoside hydrolase 15-related
AES38_RS03725	COG4763	Acyl-transferase
AES38_RS03750	COG0739	heme binding
AES38_RS03750	COG1196	nuclear chromosome segregation
AES38_RS03750	COG0741	lytic transglycosylase activity
AES38_RS03760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AES38_RS03765	COG0037	tRNA processing
AES38_RS03775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AES38_RS03780	COG0302	gtp cyclohydrolase
AES38_RS03785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AES38_RS03795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AES38_RS03820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AES38_RS03825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AES38_RS03840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AES38_RS03845	COG0667	Aldo Keto reductase
AES38_RS03850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AES38_RS03855	COG0222	ribosome binding
AES38_RS03865	COG2814	Major facilitator Superfamily
AES38_RS03870	COG1609	Transcriptional regulator
AES38_RS03875	COG1653	transport
AES38_RS03880	COG1175	transmembrane transport
AES38_RS03885	COG0395	ABC-type sugar transport system, permease component
AES38_RS03890	COG1132	(ABC) transporter
AES38_RS03915	COG0328	RNA-DNA hybrid ribonuclease activity
AES38_RS03920	COG1609	Transcriptional regulator
AES38_RS03935	COG2160	L-arabinose isomerase activity
AES38_RS03940	COG4213	ABC transporter substrate-binding protein
AES38_RS03945	COG1129	ABC transporter
AES38_RS03950	COG4214	carbohydrate transport
AES38_RS03955	COG2115	Belongs to the xylose isomerase family
AES38_RS03970	COG1846	Transcriptional regulator
AES38_RS03980	COG0583	DNA-binding transcription factor activity
AES38_RS03990	COG2814	Major facilitator Superfamily
AES38_RS04010	COG2197	response regulator
AES38_RS04010	COG3903	Transcriptional regulator
AES38_RS04015	COG0702	epimerase
AES38_RS04025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AES38_RS04050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AES38_RS04065	COG0579	oxidoreductase
AES38_RS04080	COG1435	thymidine kinase activity
AES38_RS04085	COG0489	protein tyrosine kinase activity
AES38_RS04085	COG3206	protein involved in exopolysaccharide biosynthesis
AES38_RS04115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AES38_RS04120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AES38_RS04155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AES38_RS04185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AES38_RS04185	COG1754	DNA topoisomerase type I activity
AES38_RS04190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AES38_RS04195	COG0470	DNA polymerase III
AES38_RS04210	COG2027	D-alanyl-D-alanine carboxypeptidase
AES38_RS04215	COG1335	isochorismatase
AES38_RS04225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AES38_RS04235	COG1132	(ABC) transporter
AES38_RS04240	COG1131	(ABC) transporter
AES38_RS04260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AES38_RS04280	COG1175	transmembrane transport
AES38_RS04285	COG0395	ABC-type sugar transport system, permease component
AES38_RS04310	COG0477	Major facilitator Superfamily
AES38_RS04315	COG0477	Major facilitator Superfamily
AES38_RS04330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AES38_RS04335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AES38_RS04335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AES38_RS04355	COG0180	Tryptophanyl-tRNA synthetase
AES38_RS04360	COG0708	Exodeoxyribonuclease III
AES38_RS04370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AES38_RS04375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AES38_RS04380	COG1053	succinate dehydrogenase
AES38_RS04390	COG2009	succinate dehydrogenase
AES38_RS04395	COG0438	transferase activity, transferring glycosyl groups
AES38_RS04405	COG1744	ABC transporter substrate-binding protein PnrA-like
AES38_RS04410	COG1744	ABC transporter substrate-binding protein PnrA-like
AES38_RS04415	COG3845	ABC transporter
AES38_RS04420	COG4603	Belongs to the binding-protein-dependent transport system permease family
AES38_RS04425	COG1079	Belongs to the binding-protein-dependent transport system permease family
AES38_RS04440	COG1957	nucleoside hydrolase
AES38_RS04445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AES38_RS04450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AES38_RS04470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AES38_RS04495	COG4770	biotin carboxylase activity
AES38_RS04505	COG0424	maF-like protein
AES38_RS04510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AES38_RS04535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AES38_RS04560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AES38_RS04615	COG0463	Glycosyl transferase, family 2
AES38_RS04620	COG1215	transferase activity, transferring glycosyl groups
AES38_RS04635	COG0463	Glycosyl transferase, family 2
AES38_RS04655	COG1216	Glycosyl transferase, family 2
AES38_RS04680	COG1960	acyl-CoA dehydrogenase activity
AES38_RS04685	COG1482	cell wall glycoprotein biosynthetic process
AES38_RS04720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AES38_RS04725	COG1937	Protein conserved in bacteria
AES38_RS04740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AES38_RS04765	COG1309	transcriptional regulator
AES38_RS04775	COG0714	Associated with various cellular activities
AES38_RS04795	COG0745	RESPONSE REGULATOR receiver
AES38_RS04810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AES38_RS04815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AES38_RS04820	COG0653	protein targeting
AES38_RS04875	COG1329	Transcriptional regulator
AES38_RS04905	COG2814	Major facilitator Superfamily
AES38_RS04920	COG2267	carboxylic ester hydrolase activity
AES38_RS04925	COG3387	PFAM Glycoside hydrolase 15-related
AES38_RS04930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AES38_RS04955	COG1309	transcriptional regulator
AES38_RS04980	COG1082	Xylose isomerase domain protein TIM barrel
AES38_RS05000	COG2111	Na H antiporter
AES38_RS05000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AES38_RS05005	COG1006	Multisubunit Na H antiporter MnhC subunit
AES38_RS05010	COG0651	ATP synthesis coupled electron transport
AES38_RS05020	COG2212	antiporter activity
AES38_RS05030	COG0129	dihydroxy-acid dehydratase activity
AES38_RS05040	COG0440	acetolactate synthase activity
AES38_RS05045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AES38_RS05075	COG0477	Major facilitator Superfamily
AES38_RS05085	COG0473	3-isopropylmalate dehydrogenase activity
AES38_RS05090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AES38_RS05105	COG0179	Fumarylacetoacetate (FAA) hydrolase
AES38_RS05115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AES38_RS05130	COG0667	Aldo Keto reductase
AES38_RS05135	COG0667	Aldo Keto reductase
AES38_RS05165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AES38_RS05180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AES38_RS05195	COG2197	response regulator
AES38_RS05200	COG0737	Belongs to the 5'-nucleotidase family
AES38_RS05200	COG1525	nuclease
AES38_RS05200	COG4085	toxin activity
AES38_RS05235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AES38_RS05255	COG1842	Phage shock protein A
AES38_RS05280	COG0259	pyridoxamine-phosphate oxidase activity
AES38_RS05285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AES38_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS05310	COG0252	asparaginase activity
AES38_RS05315	COG1609	Transcriptional regulator
AES38_RS05320	COG1305	Transglutaminase-like
AES38_RS05330	COG0018	arginyl-trna synthetase
AES38_RS05345	COG0460	homoserine dehydrogenase
AES38_RS05350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AES38_RS05355	COG0083	homoserine kinase activity
AES38_RS05365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AES38_RS05370	COG2890	protein-(glutamine-N5) methyltransferase activity
AES38_RS05385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AES38_RS05395	COG0356	it plays a direct role in the translocation of protons across the membrane
AES38_RS05400	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AES38_RS05405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AES38_RS05410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AES38_RS05415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AES38_RS05420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AES38_RS05425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AES38_RS05430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AES38_RS05435	COG3022	response to hydroperoxide
AES38_RS05440	COG2818	Glycosylase
AES38_RS05460	COG0631	protein serine/threonine phosphatase activity
AES38_RS05465	COG2171	N-acyltransferase activity
AES38_RS05470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AES38_RS05485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AES38_RS05490	COG0583	DNA-binding transcription factor activity
AES38_RS05495	COG0489	protein tyrosine kinase activity
AES38_RS05495	COG2151	metal-sulfur cluster biosynthetic enzyme
AES38_RS05505	COG2239	Acts as a magnesium transporter
AES38_RS05515	COG0006	proline dipeptidase activity
AES38_RS05530	COG0513	Belongs to the DEAD box helicase family
AES38_RS05560	COG3173	Aminoglycoside phosphotransferase
AES38_RS05580	COG3480	Lon protease (S16) C-terminal proteolytic domain
AES38_RS05585	COG1615	UPF0182 protein
AES38_RS05600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AES38_RS05605	COG1695	Transcriptional regulator
AES38_RS05610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AES38_RS05615	COG0321	lipoyl(octanoyl) transferase activity
AES38_RS05630	COG2409	Drug exporters of the RND superfamily
AES38_RS05645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AES38_RS05700	COG1648	precorrin-2 dehydrogenase activity
AES38_RS05700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AES38_RS05705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AES38_RS05710	COG2146	nitrite reductase [NAD(P)H] activity
AES38_RS05715	COG2223	nitrite transmembrane transporter activity
AES38_RS05720	COG0243	molybdopterin cofactor binding
AES38_RS05725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AES38_RS05750	COG0400	carboxylic ester hydrolase activity
AES38_RS05755	COG0346	lactoylglutathione lyase activity
AES38_RS05770	COG2267	carboxylic ester hydrolase activity
AES38_RS05790	COG2311	Membrane
AES38_RS05810	COG2197	response regulator
AES38_RS05820	COG1129	ABC transporter
AES38_RS05825	COG4214	carbohydrate transport
AES38_RS05850	COG5002	protein histidine kinase activity
AES38_RS05855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AES38_RS05860	COG1597	lipid kinase activity
AES38_RS05885	COG2318	DinB family
AES38_RS05895	COG3833	ABC-type maltose transport systems, permease component
AES38_RS05900	COG1175	transmembrane transport
AES38_RS05910	COG1940	carbohydrate kinase activity
AES38_RS05945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AES38_RS05950	COG2197	response regulator
AES38_RS05965	COG1131	(ABC) transporter
AES38_RS05985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AES38_RS05990	COG1215	transferase activity, transferring glycosyl groups
AES38_RS06035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AES38_RS06060	COG3046	protein related to deoxyribodipyrimidine photolyase
AES38_RS06065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AES38_RS06070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AES38_RS06075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AES38_RS06085	COG0586	Pfam SNARE associated Golgi protein
AES38_RS06100	COG1070	Carbohydrate kinase
AES38_RS06145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AES38_RS06150	COG2884	Cell division ATP-binding protein ftsE
AES38_RS06160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AES38_RS06165	COG1178	ABC-type Fe3 transport system permease component
AES38_RS06170	COG3842	ATPase activity
AES38_RS06175	COG1840	ABC-type Fe3 transport system, periplasmic component
AES38_RS06180	COG2814	Major facilitator Superfamily
AES38_RS06185	COG0483	inositol monophosphate 1-phosphatase activity
AES38_RS06190	COG1162	GTPase activity
AES38_RS06195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AES38_RS06200	COG1595	DNA-templated transcription, initiation
AES38_RS06215	COG0508	dehydrogenase complex catalyzes the overall conversion of
AES38_RS06215	COG0567	Dehydrogenase, E1 component
AES38_RS06235	COG1902	pentaerythritol trinitrate reductase activity
AES38_RS06245	COG2353	YceI-like domain
AES38_RS06255	COG2814	Major facilitator Superfamily
AES38_RS06260	COG2197	response regulator
AES38_RS06280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AES38_RS06310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AES38_RS06315	COG0066	3-isopropylmalate dehydratase activity
AES38_RS06320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AES38_RS06330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AES38_RS06335	COG1181	Belongs to the D-alanine--D-alanine ligase family
AES38_RS06340	COG0463	Glycosyl transferase, family 2
AES38_RS06360	COG0714	Associated with various cellular activities
AES38_RS06375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AES38_RS06380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AES38_RS06390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AES38_RS06395	COG0571	ribonuclease III activity
AES38_RS06400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AES38_RS06410	COG1196	nuclear chromosome segregation
AES38_RS06415	COG0552	protein localization to endoplasmic reticulum
AES38_RS06430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AES38_RS06435	COG0228	four-way junction DNA binding
AES38_RS06440	COG1837	Belongs to the UPF0109 family
AES38_RS06445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AES38_RS06450	COG0336	Belongs to the RNA methyltransferase TrmD family
AES38_RS06465	COG0335	large ribosomal subunit rRNA binding
AES38_RS06475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AES38_RS06485	COG0792	nuclease activity
AES38_RS06510	COG0477	Major facilitator Superfamily
AES38_RS06515	COG0052	Belongs to the universal ribosomal protein uS2 family
AES38_RS06520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AES38_RS06525	COG0528	UMP kinase activity
AES38_RS06530	COG0233	cytoplasmic translational termination
AES38_RS06585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AES38_RS06590	COG0366	Alpha amylase catalytic
AES38_RS06615	COG0482	sulfurtransferase activity
AES38_RS06620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AES38_RS06635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AES38_RS06640	COG0154	amidase activity
AES38_RS06645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AES38_RS06650	COG0488	(ABC) transporter
AES38_RS06660	COG0586	Pfam SNARE associated Golgi protein
AES38_RS06670	COG0318	PFAM AMP-dependent synthetase and ligase
AES38_RS06685	COG0300	oxidoreductase activity
AES38_RS06690	COG0318	PFAM AMP-dependent synthetase and ligase
AES38_RS06705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AES38_RS06720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AES38_RS06740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AES38_RS06750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AES38_RS06775	COG4721	ABC-type cobalt transport system, permease component
AES38_RS06780	COG1122	ATPase activity
AES38_RS06810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AES38_RS06830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AES38_RS06845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AES38_RS06880	COG1946	Acyl-CoA thioesterase
AES38_RS06905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AES38_RS06920	COG0783	Belongs to the Dps family
AES38_RS06940	COG0544	peptidyl-prolyl cis-trans isomerase activity
AES38_RS06945	COG0740	serine-type endopeptidase activity
AES38_RS06950	COG0740	serine-type endopeptidase activity
AES38_RS06960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AES38_RS06965	COG0339	signal peptide processing
AES38_RS06985	COG0525	valine-tRNA ligase activity
AES38_RS06990	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AES38_RS07005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AES38_RS07015	COG0747	negative chemotaxis
AES38_RS07020	COG1309	transcriptional regulator
AES38_RS07025	COG4305	rare lipoprotein A
AES38_RS07035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AES38_RS07040	COG0285	dihydrofolate synthase activity
AES38_RS07050	COG0105	UTP biosynthetic process
AES38_RS07070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AES38_RS07075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AES38_RS07080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AES38_RS07085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AES38_RS07090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AES38_RS07100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AES38_RS07110	COG0799	negative regulation of ribosome biogenesis
AES38_RS07135	COG1349	DNA-binding transcription factor activity
AES38_RS07145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AES38_RS07145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AES38_RS07145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AES38_RS07150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AES38_RS07175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AES38_RS07180	COG2267	carboxylic ester hydrolase activity
AES38_RS07195	COG3321	synthase
AES38_RS07195	COG0604	alcohol dehydrogenase
AES38_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS07200	COG2353	YceI-like domain
AES38_RS07205	COG2267	carboxylic ester hydrolase activity
AES38_RS07215	COG0587	DNA-directed DNA polymerase activity
AES38_RS07220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AES38_RS07230	COG1316	TRANSCRIPTIONal
AES38_RS07245	COG0667	Aldo Keto reductase
AES38_RS07265	COG1174	glycine betaine transport
AES38_RS07320	COG1271	oxidase subunit
AES38_RS07325	COG1294	oxidase, subunit
AES38_RS07330	COG4988	ABC transporter
AES38_RS07335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AES38_RS07345	COG0512	Glutamine amidotransferase of anthranilate synthase
AES38_RS07345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AES38_RS07350	COG0495	leucyl-tRNA aminoacylation
AES38_RS07370	COG0268	Binds directly to 16S ribosomal RNA
AES38_RS07380	COG1228	amidohydrolase
AES38_RS07390	COG0481	GTPase activity
AES38_RS07435	COG1420	regulation of RNA biosynthetic process
AES38_RS07440	COG0484	heat shock protein binding
AES38_RS07445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AES38_RS07450	COG0537	adenosine 5'-monophosphoramidase activity
AES38_RS07460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AES38_RS07470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AES38_RS07475	COG4585	Histidine kinase
AES38_RS07480	COG2197	response regulator
AES38_RS07485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AES38_RS07490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AES38_RS07495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AES38_RS07505	COG1381	Involved in DNA repair and RecF pathway recombination
AES38_RS07510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AES38_RS07515	COG0673	inositol 2-dehydrogenase activity
AES38_RS07520	COG0423	glycine-tRNA ligase activity
AES38_RS07545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AES38_RS07555	COG0747	negative chemotaxis
AES38_RS07560	COG0601	transmembrane transport
AES38_RS07565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AES38_RS07620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AES38_RS07645	COG0242	peptide deformylase activity
AES38_RS07655	COG0438	transferase activity, transferring glycosyl groups
AES38_RS07665	COG2755	lipolytic protein G-D-S-L family
AES38_RS07665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AES38_RS07675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AES38_RS07680	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AES38_RS07685	COG0297	glycogen (starch) synthase activity
AES38_RS07695	COG0438	transferase activity, transferring glycosyl groups
AES38_RS07735	COG1278	Cold shock
AES38_RS07770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AES38_RS07775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AES38_RS07790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AES38_RS07815	COG1268	BioY protein
AES38_RS07820	COG1122	ATPase activity
AES38_RS07830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AES38_RS07835	COG1579	Zn-ribbon protein possibly nucleic acid-binding
AES38_RS07850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AES38_RS07860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AES38_RS07865	COG0174	glutamine synthetase
AES38_RS07890	COG0508	dehydrogenase complex catalyzes the overall conversion of
AES38_RS07895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AES38_RS07900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AES38_RS07915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AES38_RS07920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AES38_RS07935	COG0187	DNA topoisomerase II activity
AES38_RS07940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AES38_RS07945	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AES38_RS07965	COG0756	dUTP diphosphatase activity
AES38_RS07980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AES38_RS07985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AES38_RS07990	COG1250	3-hydroxyacyl-CoA dehydrogenase
AES38_RS07990	COG1024	Enoyl-CoA hydratase
AES38_RS07995	COG0183	Belongs to the thiolase family
AES38_RS08035	COG0656	L-ascorbic acid biosynthetic process
AES38_RS08045	COG2890	protein-(glutamine-N5) methyltransferase activity
AES38_RS08050	COG3693	PFAM glycoside hydrolase, family 10
AES38_RS08080	COG4221	oxidoreductase activity
AES38_RS08085	COG1309	transcriptional regulator
AES38_RS08100	COG4221	oxidoreductase activity
AES38_RS08125	COG4581	dead DEAH box helicase
AES38_RS08130	COG0805	protein transport
AES38_RS08160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AES38_RS08170	COG0215	cysteine-tRNA ligase activity
AES38_RS08175	COG1968	undecaprenyl-diphosphatase activity
AES38_RS08180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AES38_RS08190	COG0598	Magnesium transport protein CorA
AES38_RS08200	COG0484	heat shock protein binding
AES38_RS08205	COG1174	glycine betaine transport
AES38_RS08215	COG1174	glycine betaine transport
AES38_RS08220	COG1732	Glycine betaine
AES38_RS08235	COG2514	catechol 2,3-dioxygenase activity
AES38_RS08260	COG0588	phosphoglycerate mutase activity
AES38_RS08265	COG0438	transferase activity, transferring glycosyl groups
AES38_RS08275	COG0366	Alpha amylase catalytic
AES38_RS08285	COG0254	rRNA binding
AES38_RS08290	COG1119	ATPase activity
AES38_RS08295	COG0297	glycogen (starch) synthase activity
AES38_RS08300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AES38_RS08335	COG0488	(ABC) transporter
AES38_RS08340	COG2151	metal-sulfur cluster biosynthetic enzyme
AES38_RS08345	COG0396	ATPase activity
AES38_RS08350	COG2146	nitrite reductase [NAD(P)H] activity
AES38_RS08365	COG1612	heme a metabolic process
AES38_RS08370	COG0109	protoheme IX farnesyltransferase activity
AES38_RS08380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AES38_RS08385	COG0166	Belongs to the GPI family
AES38_RS08400	COG0363	glucosamine-6-phosphate deaminase activity
AES38_RS08410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AES38_RS08415	COG0149	triose-phosphate isomerase activity
AES38_RS08420	COG0126	phosphoglycerate kinase activity
AES38_RS08435	COG1481	regulation of sporulation
AES38_RS08440	COG1660	Displays ATPase and GTPase activities
AES38_RS08445	COG0322	excinuclease ABC activity
AES38_RS08455	COG0556	nucleotide-excision repair
AES38_RS08460	COG0237	dephospho-CoA kinase activity
AES38_RS08485	COG2050	protein possibly involved in aromatic compounds catabolism
AES38_RS08500	COG0469	pyruvate kinase activity
AES38_RS08510	COG0067	glutamate synthase
AES38_RS08510	COG0069	glutamate synthase activity
AES38_RS08510	COG0070	glutamate synthase
AES38_RS08515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AES38_RS08520	COG0159	tryptophan synthase activity
AES38_RS08525	COG0133	tryptophan synthase activity
AES38_RS08530	COG0134	indole-3-glycerol-phosphate synthase activity
AES38_RS08550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AES38_RS08555	COG0107	imidazoleglycerol-phosphate synthase activity
AES38_RS08560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AES38_RS08565	COG0140	phosphoribosyl-ATP diphosphatase activity
AES38_RS08570	COG0545	Peptidyl-prolyl cis-trans isomerase
AES38_RS08575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AES38_RS08585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AES38_RS08595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AES38_RS08605	COG1758	RNA polymerase activity
AES38_RS08610	COG0194	GDP metabolic process
AES38_RS08615	COG0284	orotidine-5'-phosphate decarboxylase activity
AES38_RS08620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AES38_RS08625	COG0505	Belongs to the CarA family
AES38_RS08635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AES38_RS08640	COG0540	Belongs to the ATCase OTCase family
AES38_RS08645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AES38_RS08650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AES38_RS08655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AES38_RS08665	COG1116	anion transmembrane transporter activity
AES38_RS08670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AES38_RS08675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AES38_RS08680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AES38_RS08685	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS08690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AES38_RS08695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AES38_RS08700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AES38_RS08705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AES38_RS08710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AES38_RS08715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AES38_RS08720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AES38_RS08730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AES38_RS08745	COG1196	nuclear chromosome segregation
AES38_RS08755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AES38_RS08760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AES38_RS08765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AES38_RS08770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AES38_RS08780	COG2255	four-way junction helicase activity
AES38_RS08785	COG0632	four-way junction helicase activity
AES38_RS08790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AES38_RS08795	COG0217	transcriptional regulatory protein
AES38_RS08800	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AES38_RS08805	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AES38_RS08815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AES38_RS08850	COG0386	Belongs to the glutathione peroxidase family
AES38_RS08860	COG3012	SEC-C Motif Domain Protein
AES38_RS08870	COG1461	Dihydroxyacetone kinase
AES38_RS08880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AES38_RS08885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AES38_RS08890	COG2135	peptidase activity
AES38_RS08895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AES38_RS08900	COG1845	cytochrome c oxidase, subunit III
AES38_RS08905	COG2010	Cytochrome c
AES38_RS08910	COG0723	plastoquinol--plastocyanin reductase activity
AES38_RS08915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AES38_RS08940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AES38_RS08945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AES38_RS08955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AES38_RS08965	COG0167	dihydroorotate dehydrogenase activity
AES38_RS08970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AES38_RS08975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AES38_RS08980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AES38_RS08985	COG0587	DNA-directed DNA polymerase activity
AES38_RS09005	COG1799	cell septum assembly
AES38_RS09015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AES38_RS09020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AES38_RS09025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AES38_RS09030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AES38_RS09040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AES38_RS09045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AES38_RS09055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AES38_RS09060	COG0768	penicillin binding
AES38_RS09070	COG0275	rRNA processing
AES38_RS09075	COG2001	Belongs to the MraZ family
AES38_RS09085	COG0142	geranyltranstransferase activity
AES38_RS09095	COG1388	LysM domain
AES38_RS09095	COG3942	CHAP domain
AES38_RS09100	COG2815	serine threonine protein kinase
AES38_RS09100	COG0515	serine threonine protein kinase
AES38_RS09105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AES38_RS09115	COG1940	carbohydrate kinase activity
AES38_RS09140	COG1192	Involved in chromosome partitioning
AES38_RS09155	COG1716	ATPase activity
AES38_RS09160	COG1301	dicarboxylic acid transport
AES38_RS09165	COG3290	protein histidine kinase activity
AES38_RS09170	COG4565	transcriptional regulatory protein
AES38_RS09190	COG1609	Transcriptional regulator
AES38_RS09205	COG3833	ABC-type maltose transport systems, permease component
AES38_RS09210	COG3842	ATPase activity
AES38_RS09215	COG0584	glycerophosphoryl diester phosphodiesterase
AES38_RS09270	COG0484	heat shock protein binding
AES38_RS09275	COG0438	transferase activity, transferring glycosyl groups
AES38_RS09290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AES38_RS09300	COG3608	succinylglutamate desuccinylase aspartoacylase
AES38_RS09300	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AES38_RS09320	COG0402	S-adenosylhomocysteine deaminase activity
AES38_RS09325	COG0671	phosphoesterase, PA-phosphatase related
AES38_RS09335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AES38_RS09350	COG0405	Gamma-glutamyltransferase
AES38_RS09355	COG0477	Major facilitator Superfamily
AES38_RS09360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AES38_RS09370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AES38_RS09380	COG3321	synthase
AES38_RS09380	COG0604	alcohol dehydrogenase
AES38_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS09385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AES38_RS09395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AES38_RS09410	COG0494	nUDIX hydrolase
AES38_RS09470	COG0477	Major facilitator Superfamily
AES38_RS09560	COG0582	viral genome integration into host DNA
AES38_RS09580	COG1160	GTP binding
AES38_RS09585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AES38_RS09600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AES38_RS09605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AES38_RS09620	COG0494	nUDIX hydrolase
AES38_RS09625	COG0504	CTP synthase activity
AES38_RS09630	COG0497	DNA recombination
AES38_RS09635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AES38_RS09650	COG1011	Hydrolase
AES38_RS09675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AES38_RS09690	COG2094	Belongs to the DNA glycosylase MPG family
AES38_RS09695	COG0165	Argininosuccinate lyase
AES38_RS09700	COG0137	argininosuccinate synthase activity
AES38_RS09705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AES38_RS09710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AES38_RS09715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AES38_RS09720	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AES38_RS09725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AES38_RS09730	COG0072	phenylalanine-tRNA ligase activity
AES38_RS09730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AES38_RS09735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AES38_RS09740	COG0765	amino acid transport
AES38_RS09745	COG0765	amino acid transport
AES38_RS09750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AES38_RS09755	COG1126	abc transporter atp-binding protein
AES38_RS09760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AES38_RS09765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AES38_RS09770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AES38_RS09775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AES38_RS09790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AES38_RS09795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AES38_RS09800	COG0131	Imidazoleglycerol-phosphate dehydratase
AES38_RS09805	COG1388	LysM domain
AES38_RS09810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AES38_RS09815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AES38_RS09820	COG2813	Specifically methylates the guanine in position
AES38_RS09825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AES38_RS09830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AES38_RS09835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AES38_RS09845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AES38_RS09855	COG1396	sequence-specific DNA binding
AES38_RS09860	COG1058	Belongs to the CinA family
AES38_RS09860	COG1546	Belongs to the CinA family
AES38_RS09870	COG1674	ftsk spoiiie
AES38_RS09880	COG1136	(ABC) transporter
AES38_RS09890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AES38_RS09895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AES38_RS09900	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AES38_RS09915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AES38_RS09925	COG0612	Peptidase, M16
AES38_RS09940	COG0667	Aldo Keto reductase
AES38_RS09955	COG1185	polyribonucleotide nucleotidyltransferase activity
AES38_RS09960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AES38_RS09975	COG0471	metal ion transport
AES38_RS09995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AES38_RS10020	COG0693	protein deglycase activity
AES38_RS10030	COG0783	Belongs to the Dps family
AES38_RS10035	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS10050	COG2197	response regulator
AES38_RS10055	COG2027	D-alanyl-D-alanine carboxypeptidase
AES38_RS10075	COG0277	FAD linked oxidase domain protein
AES38_RS10085	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AES38_RS10095	COG0179	Fumarylacetoacetate (FAA) hydrolase
AES38_RS10130	COG2252	PERMEase
AES38_RS10145	COG2272	Belongs to the type-B carboxylesterase lipase family
AES38_RS10160	COG2130	NADP-dependent
AES38_RS10175	COG0596	Alpha beta hydrolase
AES38_RS10180	COG4221	oxidoreductase activity
AES38_RS10190	COG0071	Belongs to the small heat shock protein (HSP20) family
AES38_RS10200	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AES38_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS10260	COG2268	Band 7 protein
AES38_RS10280	COG1175	transmembrane transport
AES38_RS10285	COG0395	ABC-type sugar transport system, permease component
AES38_RS10295	COG0277	FAD linked oxidase domain protein
AES38_RS10320	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AES38_RS10325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AES38_RS10325	COG0352	thiamine-phosphate diphosphorylase activity
AES38_RS10325	COG0351	phosphomethylpyrimidine kinase
AES38_RS10335	COG0477	Major facilitator Superfamily
AES38_RS10345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AES38_RS10350	COG0435	Glutathione S-transferase
AES38_RS10365	COG1063	alcohol dehydrogenase
AES38_RS10380	COG0028	Belongs to the TPP enzyme family
AES38_RS10395	COG0823	Involved in the tonB-independent uptake of proteins
AES38_RS10395	COG1506	peptidase
AES38_RS10415	COG0702	epimerase
AES38_RS10445	COG0196	riboflavin kinase activity
AES38_RS10460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AES38_RS10480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AES38_RS10490	COG0195	Participates in both transcription termination and antitermination
AES38_RS10495	COG0442	prolyl-tRNA aminoacylation
AES38_RS10500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AES38_RS10505	COG0318	PFAM AMP-dependent synthetase and ligase
AES38_RS10510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AES38_RS10515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AES38_RS10520	COG0750	zinc metalloprotease
AES38_RS10525	COG0515	serine threonine protein kinase
AES38_RS10525	COG2815	serine threonine protein kinase
AES38_RS10535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AES38_RS10550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AES38_RS10575	COG0714	Associated with various cellular activities
AES38_RS10605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AES38_RS10610	COG0672	)-iron permease
AES38_RS10615	COG2822	iron ion transport
AES38_RS10620	COG2837	iron assimilation
AES38_RS10630	COG1217	gtp-binding protein TYPA
AES38_RS10635	COG4166	transmembrane transport
AES38_RS10675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AES38_RS10685	COG3639	organic phosphonate transmembrane transporter activity
AES38_RS10695	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AES38_RS10710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AES38_RS10710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AES38_RS10715	COG0509	glycine decarboxylation via glycine cleavage system
AES38_RS10720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AES38_RS10735	COG2372	response to copper ion
AES38_RS10770	COG0531	amino acid
AES38_RS10780	COG1113	amino acid transport
AES38_RS10800	COG0012	GTP binding
AES38_RS10815	COG0012	GTP binding
AES38_RS10825	COG1322	Protein conserved in bacteria
AES38_RS10830	COG0191	fructose-bisphosphate aldolase activity
AES38_RS10840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AES38_RS10845	COG1570	exodeoxyribonuclease VII activity
AES38_RS10850	COG1722	exodeoxyribonuclease VII activity
AES38_RS10865	COG0114	fumarate hydratase activity
AES38_RS10870	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AES38_RS10875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AES38_RS10885	COG1653	transport
AES38_RS10890	COG0395	ABC-type sugar transport system, permease component
AES38_RS10895	COG1175	transmembrane transport
AES38_RS10910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AES38_RS10920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AES38_RS10925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AES38_RS10945	COG1704	LemA family
AES38_RS10950	COG2723	6-phospho-beta-galactosidase activity
AES38_RS10960	COG0531	amino acid
AES38_RS10980	COG1366	Belongs to the anti-sigma-factor antagonist family
AES38_RS10985	COG1215	transferase activity, transferring glycosyl groups
AES38_RS11020	COG0148	phosphopyruvate hydratase activity
AES38_RS11025	COG0124	histidyl-tRNA synthetase
AES38_RS11040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AES38_RS11050	COG0193	aminoacyl-tRNA hydrolase activity
AES38_RS11055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AES38_RS11060	COG3265	gluconokinase activity
AES38_RS11065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AES38_RS11080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AES38_RS11085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AES38_RS11105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AES38_RS11110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AES38_RS11125	COG2011	ABC-type metal ion transport system permease component
AES38_RS11130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AES38_RS11145	COG0488	(ABC) transporter
AES38_RS11160	COG0521	Mo-molybdopterin cofactor biosynthetic process
AES38_RS11160	COG0315	cyclic pyranopterin monophosphate synthase activity
AES38_RS11165	COG0315	cyclic pyranopterin monophosphate synthase activity
AES38_RS11180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AES38_RS11210	COG0701	Predicted permease
AES38_RS11240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AES38_RS11245	COG5002	protein histidine kinase activity
AES38_RS11250	COG0745	RESPONSE REGULATOR receiver
AES38_RS11285	COG3842	ATPase activity
AES38_RS11295	COG0725	ABC transporter, periplasmic molybdate-binding protein
AES38_RS11380	COG1609	Transcriptional regulator
AES38_RS11445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AES38_RS11450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AES38_RS11455	COG0084	hydrolase, TatD family'
AES38_RS11460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AES38_RS11475	COG2249	NAD(P)H dehydrogenase (quinone) activity
AES38_RS11485	COG1064	alcohol dehydrogenase
AES38_RS11490	COG1309	transcriptional regulator
AES38_RS11500	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AES38_RS11505	COG2079	MmgE PrpD family protein
AES38_RS11590	COG2855	membrane
AES38_RS11600	COG2873	o-acetylhomoserine
AES38_RS11615	COG2261	transglycosylase associated protein
AES38_RS11625	COG1760	l-serine dehydratase
AES38_RS11640	COG1331	Highly conserved protein containing a thioredoxin domain
AES38_RS11645	COG0598	Magnesium transport protein CorA
AES38_RS11655	COG0318	PFAM AMP-dependent synthetase and ligase
AES38_RS11660	COG1643	Atp-dependent helicase
AES38_RS11665	COG2208	phosphoserine phosphatase activity
AES38_RS11680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AES38_RS11685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AES38_RS11685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AES38_RS11705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AES38_RS11715	COG0395	ABC-type sugar transport system, permease component
AES38_RS11720	COG1175	transmembrane transport
AES38_RS11750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AES38_RS11770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AES38_RS11785	COG1970	mechanosensitive ion channel activity
AES38_RS11850	COG1505	serine-type exopeptidase activity
AES38_RS11860	COG3883	PFAM NLP P60 protein
AES38_RS11860	COG0791	NLP P60 protein
AES38_RS11865	COG1321	iron dependent repressor
AES38_RS11870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AES38_RS11880	COG1278	Cold shock
AES38_RS11895	COG1061	Type III restriction enzyme res subunit
AES38_RS11900	COG0745	RESPONSE REGULATOR receiver
AES38_RS11905	COG2205	protein histidine kinase activity
AES38_RS11915	COG0459	protein refolding
AES38_RS11920	COG1278	Cold shock
AES38_RS11935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AES38_RS11955	COG3842	ATPase activity
AES38_RS11965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AES38_RS11970	COG0215	cysteine-tRNA ligase activity
AES38_RS11975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AES38_RS11975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AES38_RS11990	COG0745	RESPONSE REGULATOR receiver
AES38_RS11995	COG5002	protein histidine kinase activity
AES38_RS12005	COG0588	phosphoglycerate mutase activity
AES38_RS12015	COG4129	membrane
AES38_RS12020	COG0354	folic acid binding
AES38_RS12025	COG3485	protocatechuate 3,4-dioxygenase
AES38_RS12035	COG0745	RESPONSE REGULATOR receiver
AES38_RS12040	COG0454	-acetyltransferase
AES38_RS12040	COG0456	acetyltransferase
AES38_RS12045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AES38_RS12070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AES38_RS12110	COG2017	converts alpha-aldose to the beta-anomer
AES38_RS12115	COG1349	DNA-binding transcription factor activity
AES38_RS12125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AES38_RS12140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AES38_RS12145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AES38_RS12170	COG0667	Aldo Keto reductase
AES38_RS12175	COG1321	iron dependent repressor
AES38_RS12190	COG2814	Major facilitator Superfamily
AES38_RS12205	COG1404	Belongs to the peptidase S8 family
AES38_RS12230	COG1132	(ABC) transporter
AES38_RS12235	COG1132	(ABC) transporter
AES38_RS12240	COG1834	amidinotransferase
AES38_RS12260	COG0138	bifunctional purine biosynthesis protein purh
AES38_RS12280	COG0045	succinate-CoA ligase (ADP-forming) activity
AES38_RS12300	COG0584	glycerophosphoryl diester phosphodiesterase
AES38_RS12310	COG0519	Catalyzes the synthesis of GMP from XMP
AES38_RS12310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AES38_RS12325	COG0475	glutathione-regulated potassium exporter activity
AES38_RS12335	COG0516	GMP reductase activity
AES38_RS12380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AES38_RS12395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AES38_RS12400	COG1214	PFAM Peptidase M22, glycoprotease
AES38_RS12400	COG0456	acetyltransferase
AES38_RS12405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AES38_RS12410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AES38_RS12415	COG0736	holo-[acyl-carrier-protein] synthase activity
AES38_RS12420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AES38_RS12425	COG1072	(Pantothenic acid kinase))
AES38_RS12430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AES38_RS12435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AES38_RS12440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AES38_RS12455	COG0203	ribosomal protein L17
AES38_RS12460	COG0202	RNA polymerase activity
AES38_RS12465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AES38_RS12470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AES38_RS12475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AES38_RS12480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AES38_RS12485	COG0246	Mannitol dehydrogenase
AES38_RS12490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AES38_RS12500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AES38_RS12505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AES38_RS12520	COG0024	Methionine aminopeptidase
AES38_RS12525	COG0563	adenylate kinase activity
AES38_RS12535	COG0200	Binds to the 23S rRNA
AES38_RS12540	COG1841	ribosomal large subunit assembly
AES38_RS12545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AES38_RS12550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AES38_RS12555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AES38_RS12560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AES38_RS12565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AES38_RS12570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AES38_RS12575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AES38_RS12580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AES38_RS12585	COG0255	Belongs to the universal ribosomal protein uL29 family
AES38_RS12590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AES38_RS12595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AES38_RS12600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AES38_RS12605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AES38_RS12610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AES38_RS12615	COG0089	rRNA binding
AES38_RS12620	COG0088	Forms part of the polypeptide exit tunnel
AES38_RS12625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AES38_RS12630	COG0051	transcription antitermination factor activity, RNA binding
AES38_RS12640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AES38_RS12645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AES38_RS12650	COG0049	tRNA binding
AES38_RS12655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AES38_RS12670	COG1126	abc transporter atp-binding protein
AES38_RS12675	COG0765	amino acid transport
AES38_RS12680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AES38_RS12690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AES38_RS12695	COG0085	RNA polymerase activity
AES38_RS12710	COG2133	pyrroloquinoline quinone binding
AES38_RS12740	COG1673	EVE domain
AES38_RS12760	COG1309	transcriptional regulator
AES38_RS12775	COG1201	RNA secondary structure unwinding
AES38_RS12780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AES38_RS12785	COG0531	amino acid
AES38_RS12805	COG0154	amidase activity
AES38_RS12810	COG0753	catalase activity
AES38_RS12820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AES38_RS12855	COG1132	(ABC) transporter
AES38_RS12865	COG2197	response regulator
AES38_RS12880	COG0859	PFAM glycosyl transferase family 9
AES38_RS12910	COG1846	Transcriptional regulator
AES38_RS12940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AES38_RS12945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AES38_RS12945	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AES38_RS12950	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS12975	COG0859	PFAM glycosyl transferase family 9
AES38_RS12980	COG1609	Transcriptional regulator
AES38_RS12990	COG0395	ABC-type sugar transport system, permease component
AES38_RS13015	COG1012	belongs to the aldehyde dehydrogenase family
AES38_RS13065	COG0739	heme binding
AES38_RS13065	COG1196	nuclear chromosome segregation
AES38_RS13065	COG0741	lytic transglycosylase activity
AES38_RS13145	COG1366	Belongs to the anti-sigma-factor antagonist family
AES38_RS13165	COG0778	Nitroreductase
AES38_RS13190	COG1175	transmembrane transport
AES38_RS13195	COG0395	ABC-type sugar transport system, permease component
AES38_RS13210	COG0657	acetylesterase activity
AES38_RS13225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AES38_RS13235	COG1120	ATPase activity
AES38_RS13240	COG2226	methyltransferase
AES38_RS13245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AES38_RS13255	COG3850	Histidine kinase
AES38_RS13260	COG2197	response regulator
AES38_RS13335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AES38_RS13340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AES38_RS13345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AES38_RS13370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AES38_RS13390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AES38_RS13400	COG2205	protein histidine kinase activity
AES38_RS13405	COG0745	RESPONSE REGULATOR receiver
AES38_RS13415	COG0823	Involved in the tonB-independent uptake of proteins
AES38_RS13460	COG1660	Displays ATPase and GTPase activities
AES38_RS13475	COG0081	regulation of translation
AES38_RS13480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AES38_RS13490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AES38_RS13500	COG0436	Aminotransferase
AES38_RS13505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AES38_RS13515	COG2030	dehydratase
AES38_RS13540	COG0667	Aldo Keto reductase
AES38_RS13545	COG0366	Alpha amylase catalytic
AES38_RS13550	COG0739	heme binding
AES38_RS13570	COG0667	Aldo Keto reductase
AES38_RS13580	COG1666	GTP binding
AES38_RS13585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AES38_RS13590	COG1846	Transcriptional regulator
AES38_RS13605	COG0142	geranyltranstransferase activity
AES38_RS13610	COG2226	methyltransferase
AES38_RS13615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AES38_RS13620	COG2365	Tyrosine phosphatase family
AES38_RS13625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AES38_RS13650	COG0406	alpha-ribazole phosphatase activity
AES38_RS13660	COG3590	peptidase
AES38_RS13665	COG2233	PERMEase
AES38_RS13680	COG1335	isochorismatase
AES38_RS13685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AES38_RS13695	COG0546	phosphoglycolate phosphatase activity
AES38_RS13705	COG2040	homocysteine
AES38_RS13715	COG0702	epimerase
AES38_RS13720	COG1733	regulation of RNA biosynthetic process
AES38_RS13730	COG0667	Aldo Keto reductase
AES38_RS13750	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AES38_RS13750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AES38_RS13755	COG1609	Transcriptional regulator
AES38_RS13820	COG0534	Mate efflux family protein
AES38_RS13835	COG0656	L-ascorbic acid biosynthetic process
AES38_RS13870	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AES38_RS13880	COG1846	Transcriptional regulator
AES38_RS13910	COG4565	transcriptional regulatory protein
AES38_RS13915	COG3290	protein histidine kinase activity
AES38_RS13920	COG2851	Citrate transporter
AES38_RS13935	COG0583	DNA-binding transcription factor activity
AES38_RS13985	COG0142	geranyltranstransferase activity
AES38_RS13990	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AES38_RS14005	COG2409	Drug exporters of the RND superfamily
AES38_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
AES38_RS14045	COG0686	Belongs to the AlaDH PNT family
AES38_RS14060	COG1733	regulation of RNA biosynthetic process
AES38_RS14070	COG0717	Belongs to the dCTP deaminase family
AES38_RS14095	COG2186	Transcriptional regulator
AES38_RS14100	COG3265	gluconokinase activity
AES38_RS14110	COG0259	pyridoxamine-phosphate oxidase activity
AES38_RS14130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AES38_RS14140	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AES38_RS14170	COG3546	catalase activity
AES38_RS14175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AES38_RS14180	COG0588	phosphoglycerate mutase activity
AES38_RS14205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AES38_RS14210	COG1362	aminopeptidase activity
AES38_RS14235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AES38_RS14250	COG1120	ATPase activity
AES38_RS14255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AES38_RS14260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AES38_RS14265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AES38_RS14280	COG0776	regulation of translation
AES38_RS14285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AES38_RS14290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AES38_RS14295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AES38_RS14310	COG3842	ATPase activity
AES38_RS14325	COG0022	dehydrogenase e1 component
AES38_RS14335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AES38_RS14355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AES38_RS14360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AES38_RS14375	COG1940	carbohydrate kinase activity
AES38_RS14380	COG1929	Belongs to the glycerate kinase type-1 family
AES38_RS14385	COG0438	transferase activity, transferring glycosyl groups
AES38_RS14390	COG0659	secondary active sulfate transmembrane transporter activity
AES38_RS14400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AES38_RS14410	COG0305	Participates in initiation and elongation during chromosome replication
AES38_RS14415	COG0359	binds to the 23S rRNA
AES38_RS14420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AES38_RS14430	COG0360	Binds together with S18 to 16S ribosomal RNA
AES38_RS14435	COG0617	tRNA 3'-terminal CCA addition
AES38_RS14450	COG0492	ferredoxin-NADP+ reductase activity
AES38_RS14455	COG3118	belongs to the thioredoxin family
AES38_RS14460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AES38_RS14465	COG1181	Belongs to the D-alanine--D-alanine ligase family
AES38_RS14475	COG1192	Involved in chromosome partitioning
AES38_RS14480	COG0357	Ribosomal RNA small subunit methyltransferase G
AES38_RS14490	COG0706	membrane insertase activity
AES38_RS14495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AES38_RS14500	COG0594	ribonuclease P activity
AES38_RS14505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AES38_RS14565	COG1192	Involved in chromosome partitioning
AES38_RS14670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AES38_RS14685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AES38_RS14850	COG0489	protein tyrosine kinase activity
AES38_RS14925	COG2135	peptidase activity
AES38_RS14960	COG0738	Major facilitator superfamily
AES38_RS14965	COG1501	Belongs to the glycosyl hydrolase 31 family
AES38_RS14970	COG0395	ABC-type sugar transport system, permease component
AES38_RS14975	COG1175	transmembrane transport
AES38_RS14985	COG3507	Belongs to the glycosyl hydrolase 43 family
AES38_RS15000	COG2814	Major facilitator Superfamily
AES38_RS15005	COG1472	Belongs to the glycosyl hydrolase 3 family
AES38_RS15030	COG1175	transmembrane transport
AES38_RS15035	COG0395	ABC-type sugar transport system, permease component
AES38_RS15040	COG1609	Transcriptional regulator
AES38_RS15070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AES38_RS15250	COG2184	nucleotidyltransferase activity
AES38_RS15330	COG0446	pyridine nucleotide-disulphide oxidoreductase
AES38_RS15335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AES38_RS15340	COG1937	Protein conserved in bacteria
AES38_RS15345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AES38_RS15595	COG0436	Aminotransferase