locus-tag	class	description
DN605_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DN605_RS00040	COG0187	DNA topoisomerase II activity
DN605_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN605_RS00060	COG0328	RNA-DNA hybrid ribonuclease activity
DN605_RS00070	COG0423	glycine-tRNA ligase activity
DN605_RS00085	COG1217	gtp-binding protein TYPA
DN605_RS00095	COG1695	Transcriptional regulator
DN605_RS00110	COG0051	transcription antitermination factor activity, RNA binding
DN605_RS00115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DN605_RS00120	COG0088	Forms part of the polypeptide exit tunnel
DN605_RS00125	COG0089	rRNA binding
DN605_RS00135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DN605_RS00140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DN605_RS00145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DN605_RS00150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DN605_RS00155	COG0255	Belongs to the universal ribosomal protein uL29 family
DN605_RS00160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DN605_RS00165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DN605_RS00170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DN605_RS00175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DN605_RS00180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DN605_RS00185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DN605_RS00190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DN605_RS00200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DN605_RS00205	COG1841	ribosomal large subunit assembly
DN605_RS00210	COG0200	Binds to the 23S rRNA
DN605_RS00220	COG0563	adenylate kinase activity
DN605_RS00235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DN605_RS00245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DN605_RS00255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DN605_RS00260	COG0202	RNA polymerase activity
DN605_RS00265	COG0203	ribosomal protein L17
DN605_RS00280	COG1131	(ABC) transporter
DN605_RS00285	COG1725	Transcriptional regulator
DN605_RS00290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN605_RS00295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DN605_RS00300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DN605_RS00320	COG0193	aminoacyl-tRNA hydrolase activity
DN605_RS00325	COG1720	tRNA m6t6A37 methyltransferase activity
DN605_RS00335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DN605_RS00340	COG1794	racemase activity, acting on amino acids and derivatives
DN605_RS00355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN605_RS00360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN605_RS00375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DN605_RS00390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DN605_RS00395	COG1923	regulation of RNA biosynthetic process
DN605_RS00405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DN605_RS00410	COG1799	cell septum assembly
DN605_RS00425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DN605_RS00430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DN605_RS00445	COG0745	RESPONSE REGULATOR receiver
DN605_RS00450	COG2205	protein histidine kinase activity
DN605_RS00460	COG0569	domain protein
DN605_RS00465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN605_RS00475	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DN605_RS00480	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DN605_RS00485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DN605_RS00495	COG2205	protein histidine kinase activity
DN605_RS00500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DN605_RS00515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN605_RS00540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DN605_RS00540	COG0519	Catalyzes the synthesis of GMP from XMP
DN605_RS00550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DN605_RS00555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DN605_RS00560	COG0367	asparagine synthase
DN605_RS00580	COG0504	CTP synthase activity
DN605_RS00610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DN605_RS00650	COG0745	RESPONSE REGULATOR receiver
DN605_RS00660	COG0246	Mannitol dehydrogenase
DN605_RS00665	COG1312	Catalyzes the dehydration of D-mannonate
DN605_RS00670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DN605_RS00675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DN605_RS00680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DN605_RS00685	COG1063	alcohol dehydrogenase
DN605_RS00705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DN605_RS00745	COG0166	Belongs to the GPI family
DN605_RS00760	COG0582	viral genome integration into host DNA
DN605_RS00780	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DN605_RS00805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DN605_RS00815	COG2801	Transposase and inactivated derivatives
DN605_RS00825	COG1216	Glycosyl transferase, family 2
DN605_RS00865	COG2337	Toxic component of a toxin-antitoxin (TA) module
DN605_RS00890	COG1396	sequence-specific DNA binding
DN605_RS00935	COG3196	Protein conserved in bacteria
DN605_RS01100	COG0551	DNA topoisomerase type I activity
DN605_RS01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN605_RS01210	COG3617	BRO family, N-terminal domain
DN605_RS01230	COG1475	DNA binding
DN605_RS01235	COG1192	Involved in chromosome partitioning
DN605_RS01245	COG1910	domain protein
DN605_RS01300	COG3843	relaxase mobilization nuclease domain protein
DN605_RS01335	COG0551	DNA topoisomerase type I activity
DN605_RS01335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN605_RS01360	COG0791	NLP P60 protein
DN605_RS01360	COG1388	LysM domain
DN605_RS01420	COG0358	DNA primase activity
DN605_RS01455	COG1396	sequence-specific DNA binding
DN605_RS01530	COG3340	Belongs to the peptidase S51 family
DN605_RS01535	COG0500	methyltransferase
DN605_RS01645	COG0202	RNA polymerase activity
DN605_RS01770	COG1397	ADP-ribosylglycohydrolase
DN605_RS01925	COG1388	LysM domain
DN605_RS01925	COG0791	NLP P60 protein
DN605_RS01985	COG1475	DNA binding
DN605_RS02275	COG0017	Asparaginyl-tRNA synthetase
DN605_RS02280	COG1191	sigma factor activity
DN605_RS02295	COG0481	GTPase activity
DN605_RS02305	COG0280	phosphate acetyltransferase
DN605_RS02315	COG2801	Transposase and inactivated derivatives
DN605_RS02320	COG2801	Transposase and inactivated derivatives
DN605_RS02325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN605_RS02330	COG1876	peptidase activity
DN605_RS02335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DN605_RS02355	COG2002	toxin-antitoxin pair type II binding
DN605_RS02360	COG0564	pseudouridine synthase activity
DN605_RS02365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DN605_RS02370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN605_RS02375	COG5002	protein histidine kinase activity
DN605_RS02395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DN605_RS02450	COG0745	RESPONSE REGULATOR receiver
DN605_RS02455	COG5002	protein histidine kinase activity
DN605_RS02455	COG3850	Histidine kinase
DN605_RS02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN605_RS02465	COG1802	Transcriptional regulator
DN605_RS02470	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DN605_RS02475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN605_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
DN605_RS02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DN605_RS02500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DN605_RS02500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DN605_RS02505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DN605_RS02505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DN605_RS02515	COG4948	Mandelate Racemase Muconate Lactonizing
DN605_RS02520	COG2721	sulfolactate sulfo-lyase activity
DN605_RS02550	COG0444	Belongs to the ABC transporter superfamily
DN605_RS02590	COG0569	domain protein
DN605_RS02600	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DN605_RS02605	COG0750	zinc metalloprotease
DN605_RS02635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DN605_RS02640	COG3830	Belongs to the UPF0237 family
DN605_RS02640	COG0560	Phosphoserine phosphatase
DN605_RS02645	COG0561	phosphatase activity
DN605_RS02650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN605_RS02650	COG1918	ferrous iron import across plasma membrane
DN605_RS02660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN605_RS02665	COG1120	ATPase activity
DN605_RS02675	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DN605_RS02720	COG0038	chloride channel
DN605_RS02725	COG2205	protein histidine kinase activity
DN605_RS02730	COG0745	RESPONSE REGULATOR receiver
DN605_RS02745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DN605_RS02755	COG1473	amidohydrolase
DN605_RS02760	COG1737	Transcriptional regulator
DN605_RS02765	COG1288	antiporter activity
DN605_RS02780	COG2376	Dihydroxyacetone kinase
DN605_RS02785	COG2376	Dihydroxyacetone kinase
DN605_RS02790	COG2390	Transcriptional regulator
DN605_RS02825	COG3639	organic phosphonate transmembrane transporter activity
DN605_RS02835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DN605_RS02850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN605_RS02860	COG1960	acyl-CoA dehydrogenase activity
DN605_RS02865	COG3314	Sporulation integral membrane protein YlbJ
DN605_RS02870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DN605_RS02885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DN605_RS02895	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DN605_RS02900	COG1522	sequence-specific DNA binding
DN605_RS02905	COG1228	amidohydrolase
DN605_RS02915	COG0583	DNA-binding transcription factor activity
DN605_RS02935	COG3404	Formiminotransferase-cyclodeaminase
DN605_RS02950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DN605_RS02960	COG2116	formate transmembrane transporter activity
DN605_RS02965	COG5002	protein histidine kinase activity
DN605_RS02970	COG0745	RESPONSE REGULATOR receiver
DN605_RS02990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN605_RS03005	COG1395	domain, Protein
DN605_RS03020	COG0402	S-adenosylhomocysteine deaminase activity
DN605_RS03030	COG3956	TIGRFAM MazG family protein
DN605_RS03035	COG0776	regulation of translation
DN605_RS03040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DN605_RS03070	COG1827	regulation of RNA biosynthetic process
DN605_RS03075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DN605_RS03085	COG0686	Belongs to the AlaDH PNT family
DN605_RS03120	COG0559	Belongs to the binding-protein-dependent transport system permease family
DN605_RS03140	COG0436	Aminotransferase
DN605_RS03145	COG0436	Aminotransferase
DN605_RS03150	COG0789	Transcriptional regulator
DN605_RS03150	COG4978	Transcriptional regulator
DN605_RS03160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN605_RS03165	COG1595	DNA-templated transcription, initiation
DN605_RS03175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DN605_RS03175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DN605_RS03180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DN605_RS03185	COG1490	D-aminoacyl-tRNA deacylase activity
DN605_RS03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN605_RS03195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN605_RS03200	COG0572	uridine kinase
DN605_RS03205	COG3103	Sh3 type 3 domain protein
DN605_RS03205	COG0366	Alpha amylase catalytic
DN605_RS03240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DN605_RS03245	COG0037	tRNA processing
DN605_RS03255	COG1522	sequence-specific DNA binding
DN605_RS03260	COG0436	Aminotransferase
DN605_RS03275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DN605_RS03285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN605_RS03290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DN605_RS03300	COG0305	Participates in initiation and elongation during chromosome replication
DN605_RS03305	COG0359	binds to the 23S rRNA
DN605_RS03315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN605_RS03325	COG0582	viral genome integration into host DNA
DN605_RS03375	COG1473	amidohydrolase
DN605_RS03425	COG0747	negative chemotaxis
DN605_RS03430	COG0601	transmembrane transport
DN605_RS03440	COG0444	Belongs to the ABC transporter superfamily
DN605_RS03485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN605_RS03485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN605_RS03505	COG1686	Belongs to the peptidase S11 family
DN605_RS03510	COG1555	photosystem II stabilization
DN605_RS03515	COG0745	RESPONSE REGULATOR receiver
DN605_RS03520	COG5002	protein histidine kinase activity
DN605_RS03530	COG2873	o-acetylhomoserine
DN605_RS03540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DN605_RS03550	COG0028	Belongs to the TPP enzyme family
DN605_RS03555	COG0440	acetolactate synthase activity
DN605_RS03560	COG0028	Belongs to the TPP enzyme family
DN605_RS03565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DN605_RS03570	COG1051	belongs to the nudix hydrolase family
DN605_RS03575	COG0534	Mate efflux family protein
DN605_RS03605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DN605_RS03630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN605_RS03640	COG0129	dihydroxy-acid dehydratase activity
DN605_RS03645	COG3326	Membrane
DN605_RS03650	COG0629	single-stranded DNA binding
DN605_RS03655	COG4657	Part of a membrane complex involved in electron transport
DN605_RS03660	COG4658	electron transport chain
DN605_RS03665	COG4656	Part of a membrane complex involved in electron transport
DN605_RS03675	COG0561	phosphatase activity
DN605_RS03680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DN605_RS03685	COG0482	sulfurtransferase activity
DN605_RS03700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN605_RS03700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN605_RS03745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DN605_RS03755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DN605_RS03760	COG1984	allophanate hydrolase subunit 2
DN605_RS03770	COG0242	peptide deformylase activity
DN605_RS03775	COG0622	Phosphoesterase
DN605_RS03850	COG1288	antiporter activity
DN605_RS03855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN605_RS03955	COG1396	sequence-specific DNA binding
DN605_RS03955	COG3800	Transcriptional regulator
DN605_RS04010	COG0582	viral genome integration into host DNA
DN605_RS04070	COG0745	RESPONSE REGULATOR receiver
DN605_RS04075	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
DN605_RS04075	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DN605_RS04080	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DN605_RS04100	COG1473	amidohydrolase
DN605_RS04105	COG1288	antiporter activity
DN605_RS04110	COG0583	DNA-binding transcription factor activity
DN605_RS04115	COG0583	DNA-binding transcription factor activity
DN605_RS04120	COG0012	GTP binding
DN605_RS04130	COG0039	L-malate dehydrogenase activity
DN605_RS04140	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DN605_RS04175	COG1098	S1 RNA binding domain
DN605_RS04180	COG1228	amidohydrolase
DN605_RS04190	COG1126	abc transporter atp-binding protein
DN605_RS04195	COG0765	amino acid transport
DN605_RS04235	COG1393	Belongs to the ArsC family
DN605_RS04240	COG0583	DNA-binding transcription factor activity
DN605_RS04245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DN605_RS04250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DN605_RS04255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DN605_RS04260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DN605_RS04265	COG1757	Na H antiporter
DN605_RS04270	COG3457	Alanine racemase
DN605_RS04275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DN605_RS04330	COG4565	transcriptional regulatory protein
DN605_RS04335	COG3290	protein histidine kinase activity
DN605_RS04340	COG0356	it plays a direct role in the translocation of protons across the membrane
DN605_RS04345	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DN605_RS04350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DN605_RS04355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DN605_RS04360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DN605_RS04365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DN605_RS04370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DN605_RS04415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN605_RS04425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DN605_RS04455	COG1136	(ABC) transporter
DN605_RS04455	COG0577	efflux transmembrane transporter activity
DN605_RS04475	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DN605_RS04485	COG1609	Transcriptional regulator
DN605_RS04490	COG1873	PFAM PRC-barrel domain
DN605_RS04495	COG0733	neurotransmitter:sodium symporter activity
DN605_RS04515	COG0534	Mate efflux family protein
DN605_RS04535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DN605_RS04540	COG1268	BioY protein
DN605_RS04550	COG4120	Belongs to the binding-protein-dependent transport system permease family
DN605_RS04555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DN605_RS04560	COG1132	(ABC) transporter
DN605_RS04570	COG4978	Transcriptional regulator
DN605_RS04570	COG0789	Transcriptional regulator
DN605_RS04575	COG0784	Response regulator, receiver
DN605_RS04580	COG3290	protein histidine kinase activity
DN605_RS04680	COG4383	Mu-like prophage protein gp29
DN605_RS04700	COG4397	Mu-like prophage major head subunit gpT
DN605_RS04820	COG0445	tRNA wobble uridine modification
DN605_RS04830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN605_RS04845	COG0686	Belongs to the AlaDH PNT family
DN605_RS04850	COG1757	Na H antiporter
DN605_RS04855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DN605_RS04860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN605_RS04875	COG2720	vancomycin resistance protein
DN605_RS04890	COG0151	Belongs to the GarS family
DN605_RS04895	COG0138	bifunctional purine biosynthesis protein purh
DN605_RS04920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DN605_RS04925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DN605_RS04930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DN605_RS04940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DN605_RS04950	COG0671	phosphoesterase, PA-phosphatase related
DN605_RS04965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DN605_RS04970	COG1979	alcohol dehydrogenase
DN605_RS04995	COG0052	Belongs to the universal ribosomal protein uS2 family
DN605_RS05000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DN605_RS05015	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DN605_RS05020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN605_RS05025	COG0668	transmembrane transport
DN605_RS05055	COG1187	pseudouridine synthase activity
DN605_RS05060	COG2508	Transcriptional regulator
DN605_RS05065	COG2884	Cell division ATP-binding protein ftsE
DN605_RS05070	COG2177	Part of the ABC transporter FtsEX involved in
DN605_RS05075	COG1196	nuclear chromosome segregation
DN605_RS05075	COG0741	lytic transglycosylase activity
DN605_RS05075	COG0739	heme binding
DN605_RS05175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DN605_RS05210	COG0756	dUTP diphosphatase activity
DN605_RS05245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DN605_RS05250	COG3773	Cell wall hydrolase
DN605_RS05250	COG3409	Peptidoglycan-binding domain 1 protein
DN605_RS05255	COG0587	DNA-directed DNA polymerase activity
DN605_RS05290	COG0270	DNA (cytosine-5-)-methyltransferase activity
DN605_RS05295	COG0270	DNA (cytosine-5-)-methyltransferase activity
DN605_RS05310	COG1388	LysM domain
DN605_RS05310	COG3584	3D domain protein
DN605_RS05380	COG1704	LemA family
DN605_RS05390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DN605_RS05635	COG0582	viral genome integration into host DNA
DN605_RS05670	COG1104	cysteine desulfurase activity
DN605_RS05705	COG0776	regulation of translation
DN605_RS05840	COG4373	Mu-like prophage FluMu protein gp28
DN605_RS05910	COG0740	serine-type endopeptidase activity
DN605_RS06130	COG1373	ATPase (AAA superfamily
DN605_RS06150	COG0653	protein targeting
DN605_RS06160	COG4977	sequence-specific DNA binding
DN605_RS06160	COG1917	Cupin 2, conserved barrel domain protein
DN605_RS06185	COG1116	anion transmembrane transporter activity
DN605_RS06260	COG1321	iron dependent repressor
DN605_RS06290	COG1132	(ABC) transporter
DN605_RS06290	COG2375	cellular response to nickel ion
DN605_RS06295	COG1132	(ABC) transporter
DN605_RS06310	COG0601	transmembrane transport
DN605_RS06315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN605_RS06330	COG0747	negative chemotaxis
DN605_RS06370	COG1129	ABC transporter
DN605_RS06380	COG1132	(ABC) transporter
DN605_RS06380	COG2375	cellular response to nickel ion
DN605_RS06385	COG2375	cellular response to nickel ion
DN605_RS06385	COG1132	(ABC) transporter
DN605_RS06395	COG0745	RESPONSE REGULATOR receiver
DN605_RS06405	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DN605_RS06440	COG1129	ABC transporter
DN605_RS06460	COG1129	ABC transporter
DN605_RS06520	COG2375	cellular response to nickel ion
DN605_RS06520	COG1132	(ABC) transporter
DN605_RS06525	COG1132	(ABC) transporter
DN605_RS06525	COG2375	cellular response to nickel ion
DN605_RS06550	COG1129	ABC transporter
DN605_RS06570	COG1132	(ABC) transporter
DN605_RS06570	COG2375	cellular response to nickel ion
DN605_RS06575	COG1132	(ABC) transporter
DN605_RS06585	COG0747	negative chemotaxis
DN605_RS06590	COG0601	transmembrane transport
DN605_RS06600	COG0444	Belongs to the ABC transporter superfamily
DN605_RS06630	COG1484	DNA-dependent DNA replication
DN605_RS06675	COG2226	methyltransferase
DN605_RS06695	COG0534	Mate efflux family protein
DN605_RS06700	COG2207	Transcriptional regulator
DN605_RS06705	COG1132	(ABC) transporter
DN605_RS06710	COG1132	(ABC) transporter
DN605_RS06755	COG0534	Mate efflux family protein
DN605_RS06810	COG1132	(ABC) transporter
DN605_RS06810	COG2375	cellular response to nickel ion
DN605_RS06815	COG1132	(ABC) transporter
DN605_RS06815	COG2375	cellular response to nickel ion
DN605_RS06830	COG2226	methyltransferase
DN605_RS06835	COG2226	methyltransferase
DN605_RS06845	COG0450	alkyl hydroperoxide reductase
DN605_RS06850	COG1309	transcriptional regulator
DN605_RS06860	COG1132	(ABC) transporter
DN605_RS06900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN605_RS06970	COG1132	(ABC) transporter
DN605_RS06975	COG1132	(ABC) transporter
DN605_RS06980	COG1129	ABC transporter
DN605_RS06995	COG1917	Cupin 2, conserved barrel domain protein
DN605_RS06995	COG4977	sequence-specific DNA binding
DN605_RS07130	COG1199	ATP-dependent helicase activity
DN605_RS07290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DN605_RS07380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN605_RS07380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN605_RS07385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN605_RS07395	COG0758	DNA mediated transformation
DN605_RS07400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN605_RS07410	COG1396	sequence-specific DNA binding
DN605_RS07415	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DN605_RS07425	COG0416	fatty acid biosynthetic process
DN605_RS07430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN605_RS07435	COG0571	ribonuclease III activity
DN605_RS07440	COG0534	Mate efflux family protein
DN605_RS07445	COG0659	secondary active sulfate transmembrane transporter activity
DN605_RS07450	COG1045	serine acetyltransferase
DN605_RS07455	COG0215	cysteine-tRNA ligase activity
DN605_RS07460	COG1687	branched-chain amino acid
DN605_RS07465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DN605_RS07475	COG1253	flavin adenine dinucleotide binding
DN605_RS07535	COG0582	viral genome integration into host DNA
DN605_RS07540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DN605_RS07550	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DN605_RS07555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DN605_RS07560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN605_RS07565	COG1924	4 iron, 4 sulfur cluster binding
DN605_RS07570	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DN605_RS07575	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DN605_RS07580	COG4770	biotin carboxylase activity
DN605_RS07595	COG5016	pyruvate
DN605_RS07595	COG0511	ligase activity, forming carbon-carbon bonds
DN605_RS07600	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DN605_RS07610	COG1914	H( )-stimulated, divalent metal cation uptake system
DN605_RS07615	COG1414	Transcriptional regulator
DN605_RS07620	COG0010	Belongs to the arginase family
DN605_RS07635	COG0583	DNA-binding transcription factor activity
DN605_RS07650	COG1114	Component of the transport system for branched-chain amino acids
DN605_RS07675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DN605_RS07680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN605_RS07690	COG0728	peptidoglycan biosynthetic process
DN605_RS07725	COG1595	DNA-templated transcription, initiation
DN605_RS07740	COG3655	Transcriptional regulator
DN605_RS07765	COG1408	metallophosphoesterase
DN605_RS07785	COG1074	ATP-dependent DNA helicase activity
DN605_RS07790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DN605_RS07800	COG0252	asparaginase activity
DN605_RS07810	COG0737	Belongs to the 5'-nucleotidase family
DN605_RS07820	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DN605_RS07820	COG0493	'glutamate synthase
DN605_RS07840	COG2205	protein histidine kinase activity
DN605_RS07850	COG0745	RESPONSE REGULATOR receiver
DN605_RS07855	COG2205	protein histidine kinase activity
DN605_RS07860	COG3872	metal-dependent enzyme
DN605_RS07865	COG2890	protein-(glutamine-N5) methyltransferase activity
DN605_RS07880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN605_RS07895	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DN605_RS07900	COG0583	DNA-binding transcription factor activity
DN605_RS07920	COG1940	carbohydrate kinase activity
DN605_RS07930	COG1660	Displays ATPase and GTPase activities
DN605_RS07940	COG1481	regulation of sporulation
DN605_RS07975	COG1368	sulfuric ester hydrolase activity
DN605_RS07980	COG0670	Belongs to the BI1 family
DN605_RS07985	COG1115	amino acid carrier protein
DN605_RS07995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DN605_RS08005	COG2801	Transposase and inactivated derivatives
DN605_RS08015	COG0072	phenylalanine-tRNA ligase activity
DN605_RS08015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN605_RS08020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DN605_RS08025	COG1136	(ABC) transporter
DN605_RS08030	COG0719	Fe-S assembly protein
DN605_RS08040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DN605_RS08040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DN605_RS08050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN605_RS08055	COG2337	Toxic component of a toxin-antitoxin (TA) module
DN605_RS08080	COG2172	sigma factor antagonist activity
DN605_RS08095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DN605_RS08100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DN605_RS08110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DN605_RS08125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN605_RS08135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DN605_RS08140	COG0439	Biotin carboxylase
DN605_RS08160	COG2205	protein histidine kinase activity
DN605_RS08165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DN605_RS08210	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DN605_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
DN605_RS08230	COG1597	lipid kinase activity
DN605_RS08235	COG1595	DNA-templated transcription, initiation
DN605_RS08250	COG0084	hydrolase, TatD family'
DN605_RS08270	COG1269	ATP hydrolysis coupled proton transport
DN605_RS08275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DN605_RS08290	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
DN605_RS08295	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DN605_RS08300	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DN605_RS08305	COG1394	ATPase activity, coupled to movement of substances
DN605_RS08310	COG1592	Rubrerythrin
DN605_RS08315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN605_RS08325	COG0765	amino acid transport
DN605_RS08330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN605_RS08335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN605_RS08355	COG0018	arginyl-trna synthetase
DN605_RS08365	COG0494	nUDIX hydrolase
DN605_RS08370	COG2890	protein-(glutamine-N5) methyltransferase activity
DN605_RS08375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DN605_RS08380	COG2002	toxin-antitoxin pair type II binding
DN605_RS08390	COG0700	Nucleoside recognition
DN605_RS08400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DN605_RS08405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN605_RS08420	COG4447	cellulose binding
DN605_RS08425	COG1595	DNA-templated transcription, initiation
DN605_RS08435	COG1028	Short-chain dehydrogenase reductase Sdr
DN605_RS08440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN605_RS08445	COG3118	belongs to the thioredoxin family
DN605_RS08450	COG0492	ferredoxin-NADP+ reductase activity
DN605_RS08460	COG0785	Cytochrome C biogenesis protein
DN605_RS08560	COG0326	Molecular chaperone. Has ATPase activity
DN605_RS08615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DN605_RS08625	COG1570	exodeoxyribonuclease VII activity
DN605_RS08645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DN605_RS08650	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DN605_RS08655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DN605_RS08660	COG1438	arginine binding
DN605_RS08665	COG0497	DNA recombination
DN605_RS08700	COG1007	ATP synthesis coupled electron transport
DN605_RS08705	COG0651	ATP synthesis coupled electron transport
DN605_RS08710	COG0651	ATP synthesis coupled electron transport
DN605_RS08715	COG0651	ATP synthesis coupled electron transport
DN605_RS08720	COG1191	sigma factor activity
DN605_RS08730	COG0528	UMP kinase activity
DN605_RS08735	COG0233	cytoplasmic translational termination
DN605_RS08745	COG0575	Belongs to the CDS family
DN605_RS08760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DN605_RS08780	COG1702	phosphate starvation-inducible protein PhoH
DN605_RS08785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DN605_RS08795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DN605_RS08800	COG1381	Involved in DNA repair and RecF pathway recombination
DN605_RS08805	COG1164	Oligoendopeptidase f
DN605_RS08810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DN605_RS08815	COG0131	Imidazoleglycerol-phosphate dehydratase
DN605_RS08820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DN605_RS08825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DN605_RS08830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DN605_RS08835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DN605_RS08840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DN605_RS08845	COG0107	imidazoleglycerol-phosphate synthase activity
DN605_RS08850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DN605_RS08860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN605_RS08875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DN605_RS08880	COG0358	DNA primase activity
DN605_RS08885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DN605_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
DN605_RS08895	COG0772	Belongs to the SEDS family
DN605_RS08900	COG0802	atpase or kinase
DN605_RS08925	COG1760	l-serine dehydratase
DN605_RS08930	COG1760	l-serine dehydratase
DN605_RS08940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DN605_RS08945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DN605_RS08960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DN605_RS08965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN605_RS08975	COG2385	sporulation resulting in formation of a cellular spore
DN605_RS08995	COG1396	sequence-specific DNA binding
DN605_RS09045	COG1484	DNA-dependent DNA replication
DN605_RS09060	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
DN605_RS09095	COG1690	Belongs to the RtcB family
DN605_RS09155	COG0194	GDP metabolic process
DN605_RS09170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DN605_RS09210	COG2369	cell adhesion
DN605_RS09385	COG1705	Flagellar rod assembly protein muramidase FlgJ
DN605_RS09385	COG1388	LysM domain
DN605_RS09480	COG0756	dUTP diphosphatase activity
DN605_RS09810	COG1862	Preprotein translocase
DN605_RS09835	COG4974	Belongs to the 'phage' integrase family
DN605_RS09840	COG0488	(ABC) transporter
DN605_RS09845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DN605_RS09855	COG3858	chitin binding
DN605_RS09855	COG1388	LysM domain
DN605_RS09870	COG1196	nuclear chromosome segregation
DN605_RS09870	COG0739	heme binding
DN605_RS09870	COG0741	lytic transglycosylase activity
DN605_RS09880	COG2239	Acts as a magnesium transporter
DN605_RS09890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DN605_RS09895	COG0066	3-isopropylmalate dehydratase activity
DN605_RS09900	COG0473	3-isopropylmalate dehydrogenase activity
DN605_RS09935	COG4974	Belongs to the 'phage' integrase family
DN605_RS09945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DN605_RS09950	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN605_RS09955	COG3546	catalase activity
DN605_RS10000	COG0281	malic enzyme
DN605_RS10010	COG1968	undecaprenyl-diphosphatase activity
DN605_RS10015	COG0740	serine-type endopeptidase activity
DN605_RS10025	COG0534	Mate efflux family protein
DN605_RS10035	COG1362	aminopeptidase activity
DN605_RS10040	COG0237	dephospho-CoA kinase activity
DN605_RS10050	COG0009	L-threonylcarbamoyladenylate synthase
DN605_RS10065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DN605_RS10070	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DN605_RS10075	COG0488	(ABC) transporter
DN605_RS10080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DN605_RS10095	COG0191	fructose-bisphosphate aldolase activity
DN605_RS10100	COG0205	6-phosphofructokinase activity
DN605_RS10105	COG0628	permease
DN605_RS10110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DN605_RS10120	COG0697	spore germination
DN605_RS10135	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DN605_RS10155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DN605_RS10180	COG1492	cobalamin metabolic process
DN605_RS10205	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DN605_RS10215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DN605_RS10220	COG1797	cobyrinic acid a,c-diamide synthase activity
DN605_RS10225	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DN605_RS10255	COG0351	phosphomethylpyrimidine kinase
DN605_RS10265	COG0745	RESPONSE REGULATOR receiver
DN605_RS10270	COG5002	protein histidine kinase activity
DN605_RS10275	COG0517	IMP dehydrogenase activity
DN605_RS10275	COG0516	GMP reductase activity
DN605_RS10300	COG0363	glucosamine-6-phosphate deaminase activity
DN605_RS10320	COG1121	(ABC) transporter
DN605_RS10335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DN605_RS10340	COG0742	ribosomal rna small subunit methyltransferase
DN605_RS10345	COG0322	excinuclease ABC activity
DN605_RS10350	COG2720	vancomycin resistance protein
DN605_RS10355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN605_RS10360	COG1193	negative regulation of DNA recombination
DN605_RS10380	COG0596	Alpha beta hydrolase
DN605_RS10420	COG1116	anion transmembrane transporter activity
DN605_RS10425	COG0366	Alpha amylase catalytic
DN605_RS10430	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DN605_RS10435	COG0235	Class ii aldolase
DN605_RS10450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DN605_RS10460	COG1757	Na H antiporter
DN605_RS10465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DN605_RS10490	COG0793	Belongs to the peptidase S41A family
DN605_RS10490	COG3409	Peptidoglycan-binding domain 1 protein
DN605_RS10495	COG0523	cobalamin synthesis protein
DN605_RS10505	COG0426	domain, Protein
DN605_RS10505	COG1773	rubredoxin
DN605_RS10515	COG1215	transferase activity, transferring glycosyl groups
DN605_RS10540	COG2323	membrane
DN605_RS10555	COG0519	Catalyzes the synthesis of GMP from XMP
DN605_RS10560	COG0582	viral genome integration into host DNA
DN605_RS10595	COG2205	protein histidine kinase activity
DN605_RS10600	COG0745	RESPONSE REGULATOR receiver
DN605_RS10615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN605_RS10615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN605_RS10635	COG0582	viral genome integration into host DNA
DN605_RS10725	COG1475	DNA binding
DN605_RS10750	COG2205	protein histidine kinase activity
DN605_RS10755	COG0745	RESPONSE REGULATOR receiver
DN605_RS10765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DN605_RS10770	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DN605_RS10790	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DN605_RS10805	COG0336	Belongs to the RNA methyltransferase TrmD family
DN605_RS10835	COG0822	iron-sulfur transferase activity
DN605_RS10840	COG2878	Part of a membrane complex involved in electron transport
DN605_RS10845	COG4657	Part of a membrane complex involved in electron transport
DN605_RS10850	COG4660	Part of a membrane complex involved in electron transport
DN605_RS10860	COG4658	electron transport chain
DN605_RS10865	COG4656	Part of a membrane complex involved in electron transport
DN605_RS10870	COG1361	Conserved repeat domain
DN605_RS10870	COG2911	Protein conserved in bacteria
DN605_RS10870	COG3266	domain, Protein
DN605_RS10875	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DN605_RS10880	COG1191	sigma factor activity
DN605_RS10915	COG1162	GTPase activity
DN605_RS10920	COG0515	serine threonine protein kinase
DN605_RS10920	COG2815	serine threonine protein kinase
DN605_RS10925	COG0631	protein serine/threonine phosphatase activity
DN605_RS10930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DN605_RS10935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DN605_RS10935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DN605_RS10940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DN605_RS10950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DN605_RS10955	COG1758	RNA polymerase activity
DN605_RS10960	COG0194	GDP metabolic process
DN605_RS10970	COG1561	YicC-like family, N-terminal region
DN605_RS10980	COG0484	heat shock protein binding
DN605_RS11000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DN605_RS11005	COG1104	cysteine desulfurase activity
DN605_RS11020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DN605_RS11030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DN605_RS11030	COG0539	negative regulation of cytoplasmic translation
DN605_RS11040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DN605_RS11045	COG2081	HI0933 family
DN605_RS11055	COG1187	pseudouridine synthase activity
DN605_RS11060	COG1686	Belongs to the peptidase S11 family
DN605_RS11075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DN605_RS11080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DN605_RS11085	COG1994	Peptidase M50
DN605_RS11090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DN605_RS11095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DN605_RS11110	COG0544	peptidyl-prolyl cis-trans isomerase activity
DN605_RS11120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DN605_RS11125	COG0792	nuclease activity
DN605_RS11130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DN605_RS11140	COG0335	large ribosomal subunit rRNA binding
DN605_RS11150	COG2384	SAM-dependent methyltransferase
DN605_RS11175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN605_RS11180	COG2255	four-way junction helicase activity
DN605_RS11190	COG0632	four-way junction helicase activity
DN605_RS11195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DN605_RS11215	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DN605_RS11220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DN605_RS11230	COG1609	Transcriptional regulator
DN605_RS11245	COG2972	Histidine kinase
DN605_RS11250	COG4753	response regulator
DN605_RS11250	COG2207	Transcriptional regulator
DN605_RS11260	COG1129	ABC transporter
DN605_RS11265	COG1879	ABC-type sugar transport system periplasmic component
DN605_RS11335	COG3196	Protein conserved in bacteria
DN605_RS11600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN605_RS11605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN605_RS11615	COG0187	DNA topoisomerase II activity
DN605_RS11630	COG1937	Protein conserved in bacteria
DN605_RS11635	COG1368	sulfuric ester hydrolase activity
DN605_RS11645	COG0217	transcriptional regulatory protein
DN605_RS11650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN605_RS11675	COG4942	peptidase
DN605_RS11715	COG3620	sequence-specific DNA binding
DN605_RS11770	COG1388	LysM domain
DN605_RS11770	COG0791	NLP P60 protein
DN605_RS11830	COG0358	DNA primase activity
DN605_RS11845	COG3340	Belongs to the peptidase S51 family
DN605_RS11875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN605_RS12010	COG3620	sequence-specific DNA binding
DN605_RS12105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DN605_RS12110	COG0436	Aminotransferase
DN605_RS12120	COG0667	Aldo Keto reductase
DN605_RS12135	COG1739	Uncharacterized protein family UPF0029
DN605_RS12165	COG0714	Associated with various cellular activities
DN605_RS12200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DN605_RS12215	COG0167	dihydroorotate dehydrogenase activity
DN605_RS12220	COG0543	2 iron, 2 sulfur cluster binding
DN605_RS12235	COG0284	orotidine-5'-phosphate decarboxylase activity
DN605_RS12240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DN605_RS12265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DN605_RS12275	COG0254	rRNA binding
DN605_RS12290	COG0525	valine-tRNA ligase activity
DN605_RS12300	COG0799	negative regulation of ribosome biogenesis
DN605_RS12305	COG1316	TRANSCRIPTIONal
DN605_RS12310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DN605_RS12320	COG1534	Rna-binding protein
DN605_RS12330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DN605_RS12335	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DN605_RS12340	COG0552	protein localization to endoplasmic reticulum
DN605_RS12355	COG1943	Transposase
DN605_RS12360	COG1196	nuclear chromosome segregation
DN605_RS12370	COG2801	Transposase and inactivated derivatives
DN605_RS12380	COG0606	chelatase, subunit chli
DN605_RS12395	COG0301	tRNA thio-modification
DN605_RS12400	COG1546	Belongs to the CinA family
DN605_RS12400	COG1058	Belongs to the CinA family
DN605_RS12405	COG0779	Required for maturation of 30S ribosomal subunits
DN605_RS12410	COG0195	Participates in both transcription termination and antitermination
DN605_RS12415	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DN605_RS12425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DN605_RS12435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DN605_RS12445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DN605_RS12450	COG0196	riboflavin kinase activity
DN605_RS12470	COG0768	penicillin binding
DN605_RS12485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN605_RS12490	COG0352	thiamine-phosphate diphosphorylase activity
DN605_RS12495	COG1114	Component of the transport system for branched-chain amino acids
DN605_RS12500	COG0537	adenosine 5'-monophosphoramidase activity
DN605_RS12510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DN605_RS12515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DN605_RS12525	COG0628	permease
DN605_RS12535	COG0584	glycerophosphoryl diester phosphodiesterase
DN605_RS12540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DN605_RS12545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DN605_RS12550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DN605_RS12555	COG0165	Argininosuccinate lyase
DN605_RS12560	COG0137	argininosuccinate synthase activity
DN605_RS12565	COG0786	glutamate:sodium symporter activity
DN605_RS12605	COG3854	ATPases associated with a variety of cellular activities
DN605_RS12625	COG0612	Peptidase, M16
DN605_RS12630	COG0612	Peptidase, M16
DN605_RS12635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DN605_RS12640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DN605_RS12650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN605_RS12655	COG2022	thiamine diphosphate biosynthetic process
DN605_RS12665	COG0352	thiamine-phosphate diphosphorylase activity
DN605_RS12670	COG0352	thiamine-phosphate diphosphorylase activity
DN605_RS12670	COG0351	phosphomethylpyrimidine kinase
DN605_RS12675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DN605_RS12690	COG1304	FMN binding
DN605_RS12725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DN605_RS12735	COG1328	CTP reductase activity
DN605_RS12740	COG0602	queuosine metabolic process
DN605_RS12745	COG5002	protein histidine kinase activity
DN605_RS12750	COG0745	RESPONSE REGULATOR receiver
DN605_RS12755	COG0704	Plays a role in the regulation of phosphate uptake
DN605_RS12760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DN605_RS12765	COG0581	inorganic phosphate transmembrane transporter activity
DN605_RS12770	COG0573	inorganic phosphate transmembrane transporter activity
DN605_RS12775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DN605_RS12780	COG2155	Conserved Protein
DN605_RS12785	COG1757	Na H antiporter
DN605_RS12805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN605_RS12810	COG0800	Aldolase
DN605_RS12820	COG0402	S-adenosylhomocysteine deaminase activity
DN605_RS12825	COG1757	Na H antiporter
DN605_RS12845	COG0436	Aminotransferase
DN605_RS12885	COG0205	6-phosphofructokinase activity
DN605_RS12890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DN605_RS12895	COG4106	trans-aconitate 2-methyltransferase activity
DN605_RS12900	COG4496	protein, YerC YecD
DN605_RS12910	COG1683	Conserved Protein
DN605_RS12915	COG4472	Bacterial protein of unknown function (DUF965)
DN605_RS12925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN605_RS12930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DN605_RS12955	COG0622	Phosphoesterase
DN605_RS12960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN605_RS12995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN605_RS13000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DN605_RS13005	COG1725	Transcriptional regulator
DN605_RS13010	COG1131	(ABC) transporter
DN605_RS13025	COG2801	Transposase and inactivated derivatives
DN605_RS13035	COG0205	6-phosphofructokinase activity
DN605_RS13060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DN605_RS13065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DN605_RS13070	COG1160	GTP binding
DN605_RS13085	COG0463	Glycosyl transferase, family 2
DN605_RS13120	COG5002	protein histidine kinase activity
DN605_RS13135	COG3906	Belongs to the UPF0473 family
DN605_RS13165	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DN605_RS13170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DN605_RS13175	COG0228	four-way junction DNA binding
DN605_RS13180	COG1837	Belongs to the UPF0109 family
DN605_RS13185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DN605_RS13190	COG2033	superoxide reductase activity
DN605_RS13205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN605_RS13210	COG4481	Protein conserved in bacteria
DN605_RS13220	COG0745	RESPONSE REGULATOR receiver
DN605_RS13225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DN605_RS13240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DN605_RS13245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DN605_RS13260	COG0577	efflux transmembrane transporter activity
DN605_RS13260	COG1136	(ABC) transporter
DN605_RS13275	COG2226	methyltransferase
DN605_RS13295	COG2205	protein histidine kinase activity
DN605_RS13305	COG3829	transcription factor binding
DN605_RS13355	COG1132	(ABC) transporter
DN605_RS13365	COG1309	transcriptional regulator
DN605_RS13375	COG2217	Heavy metal translocating P-type atpase
DN605_RS13415	COG3843	relaxase mobilization nuclease domain protein
DN605_RS13455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DN605_RS13475	COG3843	relaxase mobilization nuclease domain protein
DN605_RS13510	COG0358	DNA primase activity
DN605_RS13525	COG1408	metallophosphoesterase
DN605_RS13575	COG0741	lytic transglycosylase activity
DN605_RS13575	COG0791	NLP P60 protein
DN605_RS13620	COG1484	DNA-dependent DNA replication
DN605_RS13765	COG1484	DNA-dependent DNA replication
DN605_RS13815	COG0488	(ABC) transporter
DN605_RS13890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DN605_RS13900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN605_RS13950	COG3547	Transposase (IS116 IS110 IS902 family)
DN605_RS13975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DN605_RS13980	COG0495	leucyl-tRNA aminoacylation
DN605_RS14005	COG0786	glutamate:sodium symporter activity
DN605_RS14020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DN605_RS14025	COG0110	maltose O-acetyltransferase activity
DN605_RS14040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DN605_RS14045	COG0513	Belongs to the DEAD box helicase family
DN605_RS14050	COG0427	acetyl-CoA hydrolase
DN605_RS14085	COG0745	RESPONSE REGULATOR receiver
DN605_RS14090	COG5002	protein histidine kinase activity
DN605_RS14090	COG3850	Histidine kinase
DN605_RS14095	COG2827	Endonuclease containing a URI domain
DN605_RS14100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DN605_RS14110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DN605_RS14120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DN605_RS14135	COG1115	amino acid carrier protein
DN605_RS14140	COG0653	protein targeting
DN605_RS14150	COG0427	acetyl-CoA hydrolase
DN605_RS14160	COG3853	Toxic anion resistance protein (TelA)
DN605_RS14180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DN605_RS14185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DN605_RS14195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN605_RS14200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DN605_RS14205	COG1234	tRNA 3'-trailer cleavage
DN605_RS14210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DN605_RS14215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN605_RS14220	COG3681	Belongs to the UPF0597 family
DN605_RS14225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DN605_RS14225	COG1328	CTP reductase activity
DN605_RS14230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DN605_RS14230	COG0574	Belongs to the PEP-utilizing enzyme family
DN605_RS14245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DN605_RS14250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DN605_RS14255	COG0049	tRNA binding
DN605_RS14260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DN605_RS14265	COG1358	cellular component organization or biogenesis
DN605_RS14280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN605_RS14290	COG1307	EDD domain protein, DegV family
DN605_RS14300	COG2302	S4 RNA-binding domain
DN605_RS14310	COG2409	Drug exporters of the RND superfamily
DN605_RS14345	COG1131	(ABC) transporter
DN605_RS14370	COG4536	flavin adenine dinucleotide binding
DN605_RS14380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DN605_RS14410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DN605_RS14415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DN605_RS14435	COG1346	cytolysis
DN605_RS14440	COG1380	Effector of murein hydrolase LrgA
DN605_RS14450	COG2233	PERMEase
DN605_RS14480	COG2851	Citrate transporter
DN605_RS14500	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DN605_RS14505	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
DN605_RS14505	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DN605_RS14510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DN605_RS14515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DN605_RS14515	COG0116	Belongs to the methyltransferase superfamily
DN605_RS14520	COG1122	ATPase activity
DN605_RS14525	COG1122	ATPase activity
DN605_RS14530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DN605_RS14575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DN605_RS14580	COG0006	proline dipeptidase activity
DN605_RS14590	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DN605_RS14610	COG0733	neurotransmitter:sodium symporter activity
DN605_RS14630	COG1396	sequence-specific DNA binding
DN605_RS14640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN605_RS14645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN605_RS14650	COG0250	Participates in transcription elongation, termination and antitermination
DN605_RS14655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DN605_RS14660	COG0081	regulation of translation
DN605_RS14695	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN605_RS14705	COG0534	Mate efflux family protein
DN605_RS14715	COG3870	Protein conserved in bacteria
DN605_RS14735	COG1971	Probably functions as a manganese efflux pump
DN605_RS14750	COG1918	ferrous iron import across plasma membrane
DN605_RS14750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN605_RS14830	COG0791	NLP P60 protein
DN605_RS14830	COG1388	LysM domain
DN605_RS14855	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DN605_RS14860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DN605_RS14875	COG4496	protein, YerC YecD
DN605_RS14885	COG0786	glutamate:sodium symporter activity
DN605_RS14910	COG0436	Aminotransferase
DN605_RS14915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DN605_RS14920	COG3426	butyrate kinase activity
DN605_RS14930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN605_RS14995	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DN605_RS15000	COG3695	enzyme binding
DN605_RS15015	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DN605_RS15020	COG0268	Binds directly to 16S ribosomal RNA
DN605_RS15025	COG1295	ribonuclease BN
DN605_RS15030	COG0251	oxidation-reduction process
DN605_RS15035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN605_RS15060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DN605_RS15065	COG0492	ferredoxin-NADP+ reductase activity
DN605_RS15070	COG3118	belongs to the thioredoxin family
DN605_RS15075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DN605_RS15085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DN605_RS15090	COG1410	methionine synthase
DN605_RS15090	COG0646	methionine synthase
DN605_RS15100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DN605_RS15105	COG0405	Gamma-glutamyltransferase
DN605_RS15110	COG0708	Exodeoxyribonuclease III
DN605_RS15115	COG2502	aspartate--ammonia ligase
DN605_RS15170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DN605_RS15175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DN605_RS15180	COG0772	Belongs to the SEDS family
DN605_RS15195	COG0768	penicillin binding
DN605_RS15205	COG0275	rRNA processing
DN605_RS15215	COG1573	uracil-dna glycosylase
DN605_RS15230	COG0460	homoserine dehydrogenase
DN605_RS15235	COG4492	Belongs to the UPF0735 family
DN605_RS15240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN605_RS15250	COG0789	Transcriptional regulator
DN605_RS15255	COG3022	response to hydroperoxide
DN605_RS15260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DN605_RS15275	COG2183	response to ionizing radiation
DN605_RS15290	COG1773	rubredoxin
DN605_RS15290	COG1592	Rubrerythrin
DN605_RS15295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DN605_RS15300	COG0085	RNA polymerase activity
DN605_RS15315	COG4684	Psort location CytoplasmicMembrane, score
DN605_RS15320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DN605_RS15330	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DN605_RS15335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DN605_RS15340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DN605_RS15380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DN605_RS15385	COG0469	pyruvate kinase activity
DN605_RS15390	COG2264	protein methyltransferase activity
DN605_RS15410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DN605_RS15425	COG3842	ATPase activity
DN605_RS15435	COG1177	transmembrane transport
DN605_RS15455	COG1960	acyl-CoA dehydrogenase activity
DN605_RS15460	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN605_RS15475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN605_RS15495	COG1024	Enoyl-CoA hydratase
DN605_RS15510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DN605_RS15520	COG1966	Carbon starvation protein
DN605_RS15525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DN605_RS15535	COG0693	protein deglycase activity
DN605_RS15540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DN605_RS15550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DN605_RS15555	COG0826	peptidase U32
DN605_RS15560	COG0534	Mate efflux family protein
DN605_RS15610	COG0475	glutathione-regulated potassium exporter activity
DN605_RS15615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DN605_RS15650	COG0582	viral genome integration into host DNA
DN605_RS15680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DN605_RS15705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN605_RS15725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN605_RS15770	COG0582	viral genome integration into host DNA
DN605_RS15805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN605_RS15880	COG1074	ATP-dependent DNA helicase activity
DN605_RS15895	COG0582	viral genome integration into host DNA
DN605_RS15930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DN605_RS15945	COG0542	response to heat
DN605_RS15950	COG2768	binding domain, Protein
DN605_RS15965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN605_RS15970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN605_RS15990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN605_RS15995	COG0569	domain protein
DN605_RS16000	COG0393	Putative heavy-metal-binding
DN605_RS16040	COG0517	IMP dehydrogenase activity
DN605_RS16055	COG1216	Glycosyl transferase, family 2
DN605_RS16060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN605_RS16070	COG0640	Transcriptional regulator
DN605_RS16085	COG1309	transcriptional regulator
DN605_RS16125	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DN605_RS16135	COG2205	protein histidine kinase activity
DN605_RS16160	COG2358	TRAP transporter, solute receptor (TAXI family
DN605_RS16170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DN605_RS16190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DN605_RS16240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN605_RS16250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DN605_RS16285	COG1396	sequence-specific DNA binding
DN605_RS16395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DN605_RS16405	COG0628	permease
DN605_RS16425	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DN605_RS16450	COG0617	tRNA 3'-terminal CCA addition
DN605_RS16455	COG3541	Predicted nucleotidyltransferase
DN605_RS16460	COG1690	Belongs to the RtcB family
DN605_RS16510	COG0732	type I restriction modification DNA specificity domain
DN605_RS16520	COG4974	Belongs to the 'phage' integrase family
DN605_RS16780	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DN605_RS16795	COG3550	peptidyl-serine autophosphorylation
DN605_RS16945	COG1733	regulation of RNA biosynthetic process
DN605_RS16950	COG1846	Transcriptional regulator
DN605_RS16990	COG1396	sequence-specific DNA binding
DN605_RS16990	COG3800	Transcriptional regulator
DN605_RS17000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN605_RS17005	COG3835	regulator
DN605_RS17010	COG2379	hydroxypyruvate reductase
DN605_RS17015	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN605_RS17030	COG1297	OPT oligopeptide transporter protein
DN605_RS17060	COG0148	phosphopyruvate hydratase activity
DN605_RS17065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DN605_RS17070	COG0149	triose-phosphate isomerase activity
DN605_RS17075	COG0126	phosphoglycerate kinase activity
DN605_RS17095	COG0534	Mate efflux family protein
DN605_RS17100	COG2239	Acts as a magnesium transporter
DN605_RS17105	COG0564	pseudouridine synthase activity
DN605_RS17110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DN605_RS17115	COG3959	Transketolase, thiamine diphosphate binding domain
DN605_RS17165	COG0617	tRNA 3'-terminal CCA addition
DN605_RS17185	COG2217	Heavy metal translocating P-type atpase
DN605_RS17190	COG2801	Transposase and inactivated derivatives
DN605_RS17200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DN605_RS17240	COG0582	viral genome integration into host DNA
DN605_RS17310	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DN605_RS17325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN605_RS17335	COG0561	phosphatase activity
DN605_RS17340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DN605_RS17375	COG1473	amidohydrolase
DN605_RS17380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DN605_RS17390	COG1132	(ABC) transporter
DN605_RS17395	COG1132	(ABC) transporter
DN605_RS17420	COG2801	Transposase and inactivated derivatives
DN605_RS17435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN605_RS17440	COG0492	ferredoxin-NADP+ reductase activity
DN605_RS17445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DN605_RS17455	COG0360	Binds together with S18 to 16S ribosomal RNA
DN605_RS17465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DN605_RS17470	COG1115	amino acid carrier protein
DN605_RS17480	COG1136	(ABC) transporter
DN605_RS17490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN605_RS17495	COG1120	ATPase activity
DN605_RS17510	COG2080	2 iron, 2 sulfur cluster binding
DN605_RS17510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DN605_RS17515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DN605_RS17520	COG1120	ATPase activity
DN605_RS17545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DN605_RS17550	COG0287	Prephenate dehydrogenase
DN605_RS17555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DN605_RS17560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DN605_RS17565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DN605_RS17570	COG0077	Prephenate dehydratase
DN605_RS17570	COG1605	Chorismate mutase
DN605_RS17580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DN605_RS17610	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DN605_RS17615	COG3830	Belongs to the UPF0237 family
DN605_RS17620	COG2848	UPF0210 protein
DN605_RS17625	COG1420	regulation of RNA biosynthetic process
DN605_RS17630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DN605_RS17635	COG0443	Heat shock 70 kDa protein
DN605_RS17640	COG0484	heat shock protein binding
DN605_RS17645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DN605_RS17660	COG0745	RESPONSE REGULATOR receiver
DN605_RS17665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN605_RS17670	COG1194	a g-specific adenine glycosylase
DN605_RS17675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN605_RS17685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DN605_RS17795	COG1686	Belongs to the peptidase S11 family
DN605_RS17800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DN605_RS17805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DN605_RS17810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DN605_RS17815	COG0297	glycogen (starch) synthase activity
DN605_RS17820	COG0058	SHG alpha-glucan phosphorylase activity
DN605_RS17825	COG0698	ribose 5-phosphate isomerase
DN605_RS17830	COG1288	antiporter activity
DN605_RS17840	COG1288	antiporter activity
DN605_RS17850	COG0726	polysaccharide deacetylase
DN605_RS17855	COG1115	amino acid carrier protein
DN605_RS17870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DN605_RS17880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DN605_RS17890	COG1830	Aldolase
DN605_RS17895	COG1063	alcohol dehydrogenase
DN605_RS17900	COG1737	Transcriptional regulator
DN605_RS17905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DN605_RS17915	COG1283	sodium-dependent phosphate transmembrane transporter activity
DN605_RS17920	COG0488	(ABC) transporter
DN605_RS17960	COG0768	penicillin binding
DN605_RS17975	COG0424	maF-like protein
DN605_RS17985	COG0756	dUTP diphosphatase activity
DN605_RS17990	COG0826	peptidase U32
DN605_RS17995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DN605_RS18000	COG1489	DNA binding
DN605_RS18025	COG1470	cell adhesion involved in biofilm formation
DN605_RS18030	COG1414	Transcriptional regulator
DN605_RS18035	COG0800	Aldolase
DN605_RS18040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN605_RS18055	COG1342	Belongs to the UPF0251 family
DN605_RS18070	COG0598	Magnesium transport protein CorA
DN605_RS18075	COG5002	protein histidine kinase activity
DN605_RS18080	COG0745	RESPONSE REGULATOR receiver
DN605_RS18090	COG3547	Transposase (IS116 IS110 IS902 family)
DN605_RS18110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DN605_RS18125	COG0681	Belongs to the peptidase S26 family
DN605_RS18135	COG0420	3'-5' exonuclease activity
DN605_RS18140	COG1692	metallophosphoesterase
DN605_RS18145	COG2385	sporulation resulting in formation of a cellular spore
DN605_RS18160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DN605_RS18165	COG2003	Belongs to the UPF0758 family
DN605_RS18170	COG0556	nucleotide-excision repair
DN605_RS18180	COG1943	Transposase
DN605_RS18185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DN605_RS18200	COG0456	acetyltransferase
DN605_RS18220	COG1396	sequence-specific DNA binding
DN605_RS18240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DN605_RS18250	COG0583	DNA-binding transcription factor activity
DN605_RS18255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN605_RS18260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DN605_RS18275	COG0490	domain, Protein
DN605_RS18275	COG0471	metal ion transport
DN605_RS18285	COG3693	PFAM glycoside hydrolase, family 10
DN605_RS18295	COG0459	protein refolding
DN605_RS18305	COG0116	Belongs to the methyltransferase superfamily
DN605_RS18340	COG0583	DNA-binding transcription factor activity
DN605_RS18345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN605_RS18405	COG0697	spore germination
DN605_RS18435	COG0730	response to heat
DN605_RS18440	COG0590	tRNA wobble adenosine to inosine editing
DN605_RS18445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DN605_RS18455	COG0183	Belongs to the thiolase family
DN605_RS18460	COG1185	polyribonucleotide nucleotidyltransferase activity
DN605_RS18465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DN605_RS18480	COG1461	Dihydroxyacetone kinase
DN605_RS18490	COG1079	Belongs to the binding-protein-dependent transport system permease family
DN605_RS18495	COG4603	Belongs to the binding-protein-dependent transport system permease family
DN605_RS18500	COG3845	ABC transporter
DN605_RS18510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DN605_RS18515	COG1301	dicarboxylic acid transport
DN605_RS18525	COG1192	Involved in chromosome partitioning
DN605_RS18530	COG1475	DNA binding
DN605_RS18540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DN605_RS18550	COG1970	mechanosensitive ion channel activity
DN605_RS18560	COG0357	Ribosomal RNA small subunit methyltransferase G
DN605_RS18565	COG2894	cell division
DN605_RS18570	COG1803	Methylglyoxal synthase
DN605_RS18590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DN605_RS18595	COG1472	Belongs to the glycosyl hydrolase 3 family
DN605_RS18605	COG1774	PSP1 C-terminal conserved region
DN605_RS18610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DN605_RS18615	COG1982	Orn Lys Arg decarboxylase major
DN605_RS18620	COG1847	R3H domain protein
DN605_RS18625	COG0706	membrane insertase activity
DN605_RS18630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DN605_RS18635	COG0594	ribonuclease P activity
DN605_RS18640	COG0230	Belongs to the bacterial ribosomal protein bL34 family