locus-tag	class	description
C3348_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3348_RS00010	COG0592	DNA-directed DNA polymerase activity
C3348_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3348_RS00025	COG0187	DNA topoisomerase II activity
C3348_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3348_RS00045	COG1366	Belongs to the anti-sigma-factor antagonist family
C3348_RS00055	COG1191	sigma factor activity
C3348_RS00105	COG1827	regulation of RNA biosynthetic process
C3348_RS00110	COG0668	transmembrane transport
C3348_RS00115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3348_RS00120	COG0590	tRNA wobble adenosine to inosine editing
C3348_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3348_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3348_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3348_RS00155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3348_RS00395	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3348_RS00400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3348_RS00405	COG4463	regulation of RNA biosynthetic process
C3348_RS00410	COG3880	PFAM UvrB UvrC protein
C3348_RS00415	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C3348_RS00420	COG0542	response to heat
C3348_RS00425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3348_RS00430	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C3348_RS00435	COG4956	integral membrane protein (PIN domain superfamily)
C3348_RS00455	COG3507	Belongs to the glycosyl hydrolase 43 family
C3348_RS00465	COG2390	Transcriptional regulator
C3348_RS00470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3348_RS00475	COG0022	dehydrogenase e1 component
C3348_RS00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3348_RS00485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3348_RS00490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3348_RS00490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3348_RS00500	COG3414	Phosphotransferase system galactitol-specific IIB component
C3348_RS00505	COG3775	system Galactitol-specific IIC component
C3348_RS00520	COG0095	Lipoate-protein ligase
C3348_RS00525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3348_RS00530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3348_RS00535	COG0442	prolyl-tRNA aminoacylation
C3348_RS00540	COG0442	prolyl-tRNA aminoacylation
C3348_RS00545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3348_RS00555	COG0215	cysteine-tRNA ligase activity
C3348_RS00575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3348_RS00585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3348_RS00595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3348_RS00600	COG3688	RNA-binding protein containing a PIN domain
C3348_RS00610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3348_RS00615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3348_RS00625	COG0250	Participates in transcription elongation, termination and antitermination
C3348_RS00630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3348_RS00635	COG0081	regulation of translation
C3348_RS00640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3348_RS00645	COG0222	ribosome binding
C3348_RS00655	COG0085	RNA polymerase activity
C3348_RS00660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3348_RS00665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3348_RS00670	COG0049	tRNA binding
C3348_RS00675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3348_RS00680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3348_RS00685	COG0051	transcription antitermination factor activity, RNA binding
C3348_RS00690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3348_RS00695	COG0088	Forms part of the polypeptide exit tunnel
C3348_RS00700	COG0089	rRNA binding
C3348_RS00705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3348_RS00710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3348_RS00715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3348_RS00720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3348_RS00725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3348_RS00730	COG0255	Belongs to the universal ribosomal protein uL29 family
C3348_RS00735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3348_RS00740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3348_RS00745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3348_RS00750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3348_RS00755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3348_RS00760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3348_RS00765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3348_RS00770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3348_RS00775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3348_RS00780	COG1841	ribosomal large subunit assembly
C3348_RS00785	COG0200	Binds to the 23S rRNA
C3348_RS00795	COG0563	adenylate kinase activity
C3348_RS00800	COG0024	Methionine aminopeptidase
C3348_RS00810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3348_RS00815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3348_RS00820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3348_RS00825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3348_RS00830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3348_RS00835	COG0202	RNA polymerase activity
C3348_RS00840	COG0203	ribosomal protein L17
C3348_RS00845	COG1122	ATPase activity
C3348_RS00850	COG1122	ATPase activity
C3348_RS00855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C3348_RS00860	COG0101	tRNA pseudouridine synthase activity
C3348_RS00865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3348_RS00870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3348_RS00875	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C3348_RS01135	COG0280	phosphate acetyltransferase
C3348_RS01170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3348_RS01175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3348_RS01180	COG2897	thiosulfate sulfurtransferase activity
C3348_RS01190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3348_RS01195	COG2385	sporulation resulting in formation of a cellular spore
C3348_RS01205	COG1609	Transcriptional regulator
C3348_RS01210	COG1077	Cell shape determining protein MreB Mrl
C3348_RS01215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3348_RS01225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3348_RS01230	COG3949	Membrane
C3348_RS01235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3348_RS01240	COG1040	competence protein
C3348_RS01245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS01245	COG3711	transcriptional antiterminator
C3348_RS01250	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3348_RS01255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS01260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS01270	COG1446	asparaginase
C3348_RS01275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3348_RS01285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3348_RS01290	COG0653	protein targeting
C3348_RS01295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3348_RS01300	COG2183	response to ionizing radiation
C3348_RS01305	COG1228	amidohydrolase
C3348_RS01320	COG0802	atpase or kinase
C3348_RS01325	COG1214	PFAM Peptidase M22, glycoprotease
C3348_RS01330	COG0456	acetyltransferase
C3348_RS01335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3348_RS01370	COG3279	Response regulator of the LytR AlgR family
C3348_RS01410	COG1473	amidohydrolase
C3348_RS01430	COG0534	Mate efflux family protein
C3348_RS01435	COG0488	(ABC) transporter
C3348_RS01440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3348_RS01450	COG2221	Nitrite and sulphite reductase 4Fe-4S
C3348_RS01460	COG1151	hydroxylamine reductase activity
C3348_RS01475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3348_RS01510	COG0540	Belongs to the ATCase OTCase family
C3348_RS01515	COG0543	2 iron, 2 sulfur cluster binding
C3348_RS01520	COG0167	dihydroorotate dehydrogenase activity
C3348_RS01525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3348_RS01535	COG0583	DNA-binding transcription factor activity
C3348_RS01550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3348_RS01555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3348_RS01560	COG0459	protein refolding
C3348_RS01565	COG1691	(AIR) carboxylase
C3348_RS01570	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C3348_RS01575	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C3348_RS01580	COG0519	Catalyzes the synthesis of GMP from XMP
C3348_RS01580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3348_RS01615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3348_RS01620	COG2200	EAL domain
C3348_RS01620	COG2771	luxR family
C3348_RS01635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS01640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS01650	COG1011	Hydrolase
C3348_RS01665	COG0778	Nitroreductase
C3348_RS01670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3348_RS01675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3348_RS01680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3348_RS01685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3348_RS01690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3348_RS01695	COG0138	bifunctional purine biosynthesis protein purh
C3348_RS01700	COG0151	Belongs to the GarS family
C3348_RS01705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3348_RS01715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C3348_RS01725	COG1088	dTDP-glucose 4,6-dehydratase activity
C3348_RS01730	COG0741	lytic transglycosylase activity
C3348_RS01765	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C3348_RS01770	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C3348_RS01785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C3348_RS01795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C3348_RS01805	COG0463	Glycosyl transferase, family 2
C3348_RS01840	COG4786	Flagellar basal body rod
C3348_RS01850	COG1677	Flagellar hook-basal body complex protein FliE
C3348_RS01855	COG1766	The M ring may be actively involved in energy transduction
C3348_RS01860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3348_RS01870	COG1157	protein secretion by the type III secretion system
C3348_RS01885	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C3348_RS01890	COG4786	Flagellar basal body rod
C3348_RS01900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3348_RS01920	COG1338	Plays a role in the flagellum-specific transport system
C3348_RS01930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3348_RS01935	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3348_RS01940	COG1419	protein localization to endoplasmic reticulum
C3348_RS01950	COG1191	sigma factor activity
C3348_RS01965	COG4786	Flagellar basal body rod
C3348_RS01980	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3348_RS01980	COG1776	CheC inhibitor of MCP methylation
C3348_RS01995	COG1454	alcohol dehydrogenase
C3348_RS02000	COG1533	DNA photolyase activity
C3348_RS02015	COG1733	regulation of RNA biosynthetic process
C3348_RS02030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3348_RS02035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3348_RS02035	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3348_RS02040	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3348_RS02040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3348_RS02065	COG3716	PTS system mannose fructose sorbose family IID component
C3348_RS02075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3348_RS02080	COG3620	sequence-specific DNA binding
C3348_RS02090	COG1131	(ABC) transporter
C3348_RS02110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3348_RS02115	COG1609	Transcriptional regulator
C3348_RS02120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3348_RS02125	COG1879	ABC-type sugar transport system periplasmic component
C3348_RS02130	COG1129	ABC transporter
C3348_RS02135	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3348_RS02140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3348_RS02150	COG1473	amidohydrolase
C3348_RS02210	COG2217	Heavy metal translocating P-type atpase
C3348_RS02230	COG0586	Pfam SNARE associated Golgi protein
C3348_RS02260	COG2205	protein histidine kinase activity
C3348_RS02265	COG0745	RESPONSE REGULATOR receiver
C3348_RS02290	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C3348_RS02300	COG1122	ATPase activity
C3348_RS02305	COG0210	DNA helicase
C3348_RS02310	COG1362	aminopeptidase activity
C3348_RS02320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3348_RS02345	COG1012	belongs to the aldehyde dehydrogenase family
C3348_RS02345	COG1454	alcohol dehydrogenase
C3348_RS02355	COG1136	(ABC) transporter
C3348_RS02365	COG3290	protein histidine kinase activity
C3348_RS02395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3348_RS02400	COG2357	RelA SpoT domain protein
C3348_RS02420	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C3348_RS02445	COG1263	PTS System
C3348_RS02445	COG2190	(PTS) system
C3348_RS02445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS02450	COG2723	6-phospho-beta-galactosidase activity
C3348_RS02455	COG3711	transcriptional antiterminator
C3348_RS02465	COG0367	asparagine synthase
C3348_RS02480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3348_RS02505	COG1960	acyl-CoA dehydrogenase activity
C3348_RS02510	COG2086	electron transfer activity
C3348_RS02515	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3348_RS02520	COG3829	transcription factor binding
C3348_RS02525	COG0191	fructose-bisphosphate aldolase activity
C3348_RS02580	COG2801	Transposase and inactivated derivatives
C3348_RS02595	COG3829	transcription factor binding
C3348_RS02600	COG3804	dihydrodipicolinate reductase
C3348_RS02610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3348_RS02620	COG5012	cobalamin binding
C3348_RS02630	COG3457	Alanine racemase
C3348_RS02635	COG1757	Na H antiporter
C3348_RS02655	COG3973	AAA domain
C3348_RS02660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3348_RS02675	COG1136	(ABC) transporter
C3348_RS02685	COG5002	protein histidine kinase activity
C3348_RS02690	COG0745	RESPONSE REGULATOR receiver
C3348_RS02730	COG1737	Transcriptional regulator
C3348_RS02740	COG0561	phosphatase activity
C3348_RS02745	COG0366	Alpha amylase catalytic
C3348_RS02765	COG0655	NAD(P)H dehydrogenase (quinone) activity
C3348_RS02795	COG1131	(ABC) transporter
C3348_RS02815	COG5002	protein histidine kinase activity
C3348_RS02825	COG0577	efflux transmembrane transporter activity
C3348_RS02825	COG1136	(ABC) transporter
C3348_RS02830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3348_RS02840	COG0745	RESPONSE REGULATOR receiver
C3348_RS02845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3348_RS02860	COG1063	alcohol dehydrogenase
C3348_RS02870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS02880	COG3716	PTS system mannose fructose sorbose family IID component
C3348_RS02890	COG5002	protein histidine kinase activity
C3348_RS02900	COG1686	Belongs to the peptidase S11 family
C3348_RS02905	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3348_RS02905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3348_RS02925	COG2205	protein histidine kinase activity
C3348_RS02950	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3348_RS02955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C3348_RS02980	COG2378	regulation of single-species biofilm formation
C3348_RS02990	COG2201	protein-glutamate methylesterase activity
C3348_RS02995	COG1776	CheC inhibitor of MCP methylation
C3348_RS03000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C3348_RS03005	COG0835	chemotaxis
C3348_RS03015	COG0840	transmembrane signaling receptor activity
C3348_RS03020	COG2198	Histidine kinase
C3348_RS03020	COG0643	Histidine kinase
C3348_RS03025	COG0835	chemotaxis
C3348_RS03035	COG2201	protein-glutamate methylesterase activity
C3348_RS03085	COG2339	peptidase activity
C3348_RS03090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3348_RS03090	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C3348_RS03095	COG0681	Belongs to the peptidase S26 family
C3348_RS03110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3348_RS03115	COG2066	Belongs to the glutaminase family
C3348_RS03125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C3348_RS03145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3348_RS03150	COG1067	ATP-dependent peptidase activity
C3348_RS03155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C3348_RS03160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3348_RS03170	COG1744	ABC transporter substrate-binding protein PnrA-like
C3348_RS03195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3348_RS03275	COG1309	transcriptional regulator
C3348_RS03280	COG0574	Belongs to the PEP-utilizing enzyme family
C3348_RS03280	COG3848	Pyruvate phosphate dikinase
C3348_RS03350	COG3969	phosphoadenosine phosphosulfate
C3348_RS03355	COG1475	DNA binding
C3348_RS03370	COG3546	catalase activity
C3348_RS03380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3348_RS03405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C3348_RS03445	COG3279	Response regulator of the LytR AlgR family
C3348_RS03450	COG0577	efflux transmembrane transporter activity
C3348_RS03455	COG1136	(ABC) transporter
C3348_RS03480	COG4978	Transcriptional regulator
C3348_RS03480	COG0789	Transcriptional regulator
C3348_RS03530	COG0305	Participates in initiation and elongation during chromosome replication
C3348_RS03550	COG1132	(ABC) transporter
C3348_RS03555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3348_RS03560	COG0534	Mate efflux family protein
C3348_RS03575	COG4335	DNA alkylation repair
C3348_RS03630	COG0745	RESPONSE REGULATOR receiver
C3348_RS03635	COG2205	protein histidine kinase activity
C3348_RS03640	COG1131	(ABC) transporter
C3348_RS03650	COG3177	Filamentation induced by cAMP protein fic
C3348_RS03655	COG1802	Transcriptional regulator
C3348_RS03660	COG4946	Tricorn protease homolog
C3348_RS03660	COG0823	Involved in the tonB-independent uptake of proteins
C3348_RS03660	COG1506	peptidase
C3348_RS03665	COG4946	Tricorn protease homolog
C3348_RS03665	COG1506	peptidase
C3348_RS03665	COG0823	Involved in the tonB-independent uptake of proteins
C3348_RS03685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS03705	COG0038	chloride channel
C3348_RS03790	COG2205	protein histidine kinase activity
C3348_RS03830	COG1595	DNA-templated transcription, initiation
C3348_RS03845	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C3348_RS03865	COG2814	Major facilitator Superfamily
C3348_RS03875	COG1609	Transcriptional regulator
C3348_RS03890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3348_RS03895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3348_RS03925	COG0789	Transcriptional regulator
C3348_RS03945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3348_RS03950	COG0569	domain protein
C3348_RS03955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3348_RS03960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3348_RS03965	COG0072	phenylalanine-tRNA ligase activity
C3348_RS03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3348_RS03980	COG0826	peptidase U32
C3348_RS03990	COG1051	belongs to the nudix hydrolase family
C3348_RS04000	COG3706	GGDEF domain
C3348_RS04005	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3348_RS04010	COG1193	negative regulation of DNA recombination
C3348_RS04015	COG1683	Conserved Protein
C3348_RS04020	COG0018	arginyl-trna synthetase
C3348_RS04035	COG1032	radical SAM domain protein
C3348_RS04050	COG0280	phosphate acetyltransferase
C3348_RS04055	COG1151	hydroxylamine reductase activity
C3348_RS04065	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C3348_RS04070	COG3404	Formiminotransferase-cyclodeaminase
C3348_RS04075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3348_RS04085	COG0646	methionine synthase
C3348_RS04085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C3348_RS04090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3348_RS04120	COG0509	glycine decarboxylation via glycine cleavage system
C3348_RS04140	COG0095	Lipoate-protein ligase
C3348_RS04160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3348_RS04175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3348_RS04175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3348_RS04185	COG3192	ethanolamine utilization protein
C3348_RS04190	COG1349	DNA-binding transcription factor activity
C3348_RS04200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3348_RS04205	COG1360	Flagellar Motor Protein
C3348_RS04225	COG0210	DNA helicase
C3348_RS04230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3348_RS04235	COG0765	amino acid transport
C3348_RS04240	COG1126	abc transporter atp-binding protein
C3348_RS04250	COG0301	tRNA thio-modification
C3348_RS04260	COG0778	Nitroreductase
C3348_RS04265	COG5001	Diguanylate cyclase
C3348_RS04265	COG3300	MHYT domain
C3348_RS04270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C3348_RS04280	COG0530	calcium, potassium:sodium antiporter activity
C3348_RS04285	COG0513	Belongs to the DEAD box helicase family
C3348_RS04305	COG3732	PTS system glucitol sorbitol-specific
C3348_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
C3348_RS04340	COG0243	molybdopterin cofactor binding
C3348_RS04345	COG1366	Belongs to the anti-sigma-factor antagonist family
C3348_RS04350	COG2172	sigma factor antagonist activity
C3348_RS04355	COG1191	sigma factor activity
C3348_RS04365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3348_RS04390	COG1473	amidohydrolase
C3348_RS04405	COG0295	cytidine deaminase activity
C3348_RS04410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3348_RS04420	COG0750	zinc metalloprotease
C3348_RS04425	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS04430	COG0488	(ABC) transporter
C3348_RS04445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3348_RS04460	COG1739	Uncharacterized protein family UPF0029
C3348_RS04470	COG0730	response to heat
C3348_RS04475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3348_RS04480	COG0217	transcriptional regulatory protein
C3348_RS04490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3348_RS04505	COG1024	Enoyl-CoA hydratase
C3348_RS04510	COG2610	gluconate transmembrane transporter activity
C3348_RS04525	COG2086	electron transfer activity
C3348_RS04530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3348_RS04575	COG2186	Transcriptional regulator
C3348_RS04580	COG2814	Major facilitator Superfamily
C3348_RS04585	COG2190	(PTS) system
C3348_RS04585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS04585	COG1263	PTS System
C3348_RS04590	COG2723	6-phospho-beta-galactosidase activity
C3348_RS04600	COG0745	RESPONSE REGULATOR receiver
C3348_RS04605	COG2205	protein histidine kinase activity
C3348_RS04625	COG1592	Rubrerythrin
C3348_RS04635	COG2033	superoxide reductase activity
C3348_RS04640	COG0069	glutamate synthase activity
C3348_RS04660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3348_RS04670	COG0473	3-isopropylmalate dehydrogenase activity
C3348_RS04675	COG1846	Transcriptional regulator
C3348_RS04700	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3348_RS04705	COG0138	bifunctional purine biosynthesis protein purh
C3348_RS04715	COG0438	transferase activity, transferring glycosyl groups
C3348_RS04715	COG0297	glycogen (starch) synthase activity
C3348_RS04745	COG1473	amidohydrolase
C3348_RS04750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C3348_RS04765	COG0601	transmembrane transport
C3348_RS04770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3348_RS04780	COG0444	Belongs to the ABC transporter superfamily
C3348_RS04785	COG4608	Belongs to the ABC transporter superfamily
C3348_RS04790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3348_RS04790	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3348_RS04810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS04820	COG1486	melibiose metabolic process
C3348_RS04830	COG1073	alpha beta
C3348_RS04840	COG1910	domain protein
C3348_RS04845	COG0725	ABC transporter, periplasmic molybdate-binding protein
C3348_RS04850	COG4149	molybdate abc transporter
C3348_RS04855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3348_RS04860	COG0110	maltose O-acetyltransferase activity
C3348_RS04870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3348_RS04875	COG4120	Belongs to the binding-protein-dependent transport system permease family
C3348_RS04880	COG2984	ABC transporter substrate binding protein
C3348_RS04885	COG1122	ATPase activity
C3348_RS04895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3348_RS04895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3348_RS04925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3348_RS04930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3348_RS04935	COG0297	glycogen (starch) synthase activity
C3348_RS04940	COG0058	SHG alpha-glucan phosphorylase activity
C3348_RS04950	COG1802	Transcriptional regulator
C3348_RS04955	COG1982	Orn Lys Arg decarboxylase major
C3348_RS04960	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C3348_RS04965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C3348_RS04970	COG0010	Belongs to the arginase family
C3348_RS05020	COG4868	Belongs to the UPF0371 family
C3348_RS05025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3348_RS05035	COG1174	glycine betaine transport
C3348_RS05040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3348_RS05070	COG0534	Mate efflux family protein
C3348_RS05075	COG0539	negative regulation of cytoplasmic translation
C3348_RS05075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3348_RS05080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3348_RS05090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3348_RS05095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3348_RS05100	COG0066	3-isopropylmalate dehydratase activity
C3348_RS05105	COG0473	3-isopropylmalate dehydrogenase activity
C3348_RS05120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3348_RS05135	COG5001	Diguanylate cyclase
C3348_RS05135	COG5002	protein histidine kinase activity
C3348_RS05135	COG3447	MASE1 domain protein
C3348_RS05160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3348_RS05165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C3348_RS05175	COG0281	malic enzyme
C3348_RS05185	COG0745	RESPONSE REGULATOR receiver
C3348_RS05190	COG5002	protein histidine kinase activity
C3348_RS05195	COG1136	(ABC) transporter
C3348_RS05195	COG0577	efflux transmembrane transporter activity
C3348_RS05215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3348_RS05220	COG0363	glucosamine-6-phosphate deaminase activity
C3348_RS05235	COG5002	protein histidine kinase activity
C3348_RS05240	COG5001	Diguanylate cyclase
C3348_RS05250	COG0789	Transcriptional regulator
C3348_RS05250	COG4978	Transcriptional regulator
C3348_RS05260	COG1132	(ABC) transporter
C3348_RS05280	COG2364	Membrane
C3348_RS05290	COG3842	ATPase activity
C3348_RS05295	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3348_RS05300	COG1177	transmembrane transport
C3348_RS05305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C3348_RS05315	COG5298	Protein conserved in bacteria
C3348_RS05320	COG1215	transferase activity, transferring glycosyl groups
C3348_RS05335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C3348_RS05365	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS05370	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS05370	COG2247	cell wall binding repeat
C3348_RS05380	COG0210	DNA helicase
C3348_RS05390	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C3348_RS05395	COG1074	ATP-dependent DNA helicase activity
C3348_RS05400	COG0420	3'-5' exonuclease activity
C3348_RS05405	COG0419	ATPase involved in DNA repair
C3348_RS05410	COG4536	flavin adenine dinucleotide binding
C3348_RS05420	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3348_RS05430	COG0622	Phosphoesterase
C3348_RS05435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3348_RS05440	COG1131	(ABC) transporter
C3348_RS05460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3348_RS05465	COG1960	acyl-CoA dehydrogenase activity
C3348_RS05470	COG2086	electron transfer activity
C3348_RS05475	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3348_RS05490	COG0183	Belongs to the thiolase family
C3348_RS05495	COG0564	pseudouridine synthase activity
C3348_RS05505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3348_RS05560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3348_RS05565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS05570	COG4224	UPF0291 protein
C3348_RS05575	COG1362	aminopeptidase activity
C3348_RS05580	COG2188	Transcriptional regulator
C3348_RS05600	COG3715	PTS system
C3348_RS05605	COG3716	PTS system mannose fructose sorbose family IID component
C3348_RS05610	COG0583	DNA-binding transcription factor activity
C3348_RS05630	COG3414	Phosphotransferase system galactitol-specific IIB component
C3348_RS05635	COG1132	(ABC) transporter
C3348_RS05645	COG1473	amidohydrolase
C3348_RS05660	COG3279	Response regulator of the LytR AlgR family
C3348_RS05675	COG1882	Formate acetyltransferase
C3348_RS05680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C3348_RS05685	COG1396	sequence-specific DNA binding
C3348_RS05710	COG2207	Transcriptional regulator
C3348_RS05710	COG3708	Transcriptional regulator
C3348_RS05765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3348_RS05765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3348_RS05770	COG0237	dephospho-CoA kinase activity
C3348_RS05795	COG0346	lactoylglutathione lyase activity
C3348_RS05800	COG0791	NLP P60 protein
C3348_RS05810	COG4656	Part of a membrane complex involved in electron transport
C3348_RS05815	COG4658	electron transport chain
C3348_RS05820	COG4659	FMN binding
C3348_RS05825	COG4660	Part of a membrane complex involved in electron transport
C3348_RS05830	COG4657	Part of a membrane complex involved in electron transport
C3348_RS05835	COG1245	4Fe-4S binding domain
C3348_RS05835	COG2878	Part of a membrane complex involved in electron transport
C3348_RS05840	COG0424	maF-like protein
C3348_RS05845	COG2003	Belongs to the UPF0758 family
C3348_RS05850	COG1077	Cell shape determining protein MreB Mrl
C3348_RS05870	COG0850	regulation of cytokinetic process
C3348_RS05875	COG2894	cell division
C3348_RS05880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C3348_RS05885	COG0772	Belongs to the SEDS family
C3348_RS05890	COG1803	Methylglyoxal synthase
C3348_RS05895	COG1695	Transcriptional regulator
C3348_RS05910	COG0426	domain, Protein
C3348_RS05925	COG1530	ribonuclease E activity
C3348_RS05930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3348_RS05940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3348_RS05945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3348_RS05955	COG0460	homoserine dehydrogenase
C3348_RS05965	COG3314	Sporulation integral membrane protein YlbJ
C3348_RS05970	COG2186	Transcriptional regulator
C3348_RS05975	COG3875	lactate racemase activity
C3348_RS05980	COG2086	electron transfer activity
C3348_RS05985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3348_RS05990	COG0277	FAD linked oxidase domain protein
C3348_RS05995	COG1323	Belongs to the UPF0348 family
C3348_RS06000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3348_RS06010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3348_RS06020	COG0416	fatty acid biosynthetic process
C3348_RS06025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3348_RS06035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3348_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
C3348_RS06045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3348_RS06050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3348_RS06055	COG3706	GGDEF domain
C3348_RS06070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3348_RS06085	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C3348_RS06090	COG3854	ATPases associated with a variety of cellular activities
C3348_RS06130	COG1302	Protein conserved in bacteria
C3348_RS06135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3348_RS06140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3348_RS06145	COG1570	exodeoxyribonuclease VII activity
C3348_RS06160	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C3348_RS06165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3348_RS06170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C3348_RS06175	COG0497	DNA recombination
C3348_RS06185	COG0456	acetyltransferase
C3348_RS06190	COG0456	acetyltransferase
C3348_RS06195	COG0750	zinc metalloprotease
C3348_RS06215	COG0463	Glycosyl transferase, family 2
C3348_RS06230	COG0494	nUDIX hydrolase
C3348_RS06240	COG4974	Belongs to the 'phage' integrase family
C3348_RS06245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C3348_RS06250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C3348_RS06260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3348_RS06265	COG4122	O-methyltransferase activity
C3348_RS06270	COG0826	peptidase U32
C3348_RS06275	COG0768	penicillin binding
C3348_RS06310	COG2801	Transposase and inactivated derivatives
C3348_RS06425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3348_RS06435	COG0571	ribonuclease III activity
C3348_RS06445	COG1196	nuclear chromosome segregation
C3348_RS06450	COG0552	protein localization to endoplasmic reticulum
C3348_RS06460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3348_RS06465	COG0228	four-way junction DNA binding
C3348_RS06475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3348_RS06480	COG0336	Belongs to the RNA methyltransferase TrmD family
C3348_RS06485	COG0335	large ribosomal subunit rRNA binding
C3348_RS06495	COG1114	Component of the transport system for branched-chain amino acids
C3348_RS06510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3348_RS06540	COG1131	(ABC) transporter
C3348_RS06545	COG2197	response regulator
C3348_RS06550	COG4585	Histidine kinase
C3348_RS06555	COG0792	nuclease activity
C3348_RS06560	COG0606	chelatase, subunit chli
C3348_RS06565	COG0758	DNA mediated transformation
C3348_RS06570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3348_RS06580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3348_RS06590	COG1959	2 iron, 2 sulfur cluster binding
C3348_RS06600	COG0822	iron-sulfur transferase activity
C3348_RS06605	COG0482	sulfurtransferase activity
C3348_RS06610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3348_RS06615	COG4472	Bacterial protein of unknown function (DUF965)
C3348_RS06625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3348_RS06630	COG3906	Belongs to the UPF0473 family
C3348_RS06635	COG0735	belongs to the Fur family
C3348_RS06645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3348_RS06655	COG1686	Belongs to the peptidase S11 family
C3348_RS06665	COG1917	Cupin 2, conserved barrel domain protein
C3348_RS06665	COG2207	Transcriptional regulator
C3348_RS06670	COG1994	Peptidase M50
C3348_RS06680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3348_RS06735	COG0779	Required for maturation of 30S ribosomal subunits
C3348_RS06740	COG0195	Participates in both transcription termination and antitermination
C3348_RS06745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C3348_RS06755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3348_RS06765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C3348_RS06770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3348_RS06775	COG0196	riboflavin kinase activity
C3348_RS06785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3348_RS06790	COG1307	EDD domain protein, DegV family
C3348_RS06795	COG1185	polyribonucleotide nucleotidyltransferase activity
C3348_RS06800	COG0726	polysaccharide deacetylase
C3348_RS06805	COG0612	Peptidase, M16
C3348_RS06810	COG1873	PFAM PRC-barrel domain
C3348_RS06815	COG0527	aspartate kinase activity
C3348_RS06820	COG0740	serine-type endopeptidase activity
C3348_RS06830	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C3348_RS06835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3348_RS06845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3348_RS06850	COG1418	mRNA catabolic process
C3348_RS06865	COG1968	undecaprenyl-diphosphatase activity
C3348_RS06875	COG0114	fumarate hydratase activity
C3348_RS06885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS06885	COG1263	PTS System
C3348_RS06895	COG1486	melibiose metabolic process
C3348_RS06900	COG0436	Aminotransferase
C3348_RS06910	COG0708	Exodeoxyribonuclease III
C3348_RS06925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3348_RS06950	COG1131	(ABC) transporter
C3348_RS06980	COG1278	Cold shock
C3348_RS06990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3348_RS07070	COG3299	homolog of phage Mu protein gp47
C3348_RS07075	COG3778	Protein conserved in bacteria
C3348_RS07120	COG1396	sequence-specific DNA binding
C3348_RS07125	COG2814	Major facilitator Superfamily
C3348_RS07135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3348_RS07140	COG3273	potassium ion transport
C3348_RS07140	COG0471	metal ion transport
C3348_RS07145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3348_RS07150	COG1914	H( )-stimulated, divalent metal cation uptake system
C3348_RS07155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C3348_RS07160	COG1984	allophanate hydrolase subunit 2
C3348_RS07165	COG1396	sequence-specific DNA binding
C3348_RS07170	COG4948	Mandelate Racemase Muconate Lactonizing
C3348_RS07215	COG1473	amidohydrolase
C3348_RS07220	COG1619	proteins homologs of microcin C7 resistance protein MccF
C3348_RS07235	COG0584	glycerophosphoryl diester phosphodiesterase
C3348_RS07255	COG0488	(ABC) transporter
C3348_RS07265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS07270	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3348_RS07275	COG1546	Belongs to the CinA family
C3348_RS07275	COG1058	Belongs to the CinA family
C3348_RS07290	COG3829	transcription factor binding
C3348_RS07300	COG1242	4 iron, 4 sulfur cluster binding
C3348_RS07335	COG2801	Transposase and inactivated derivatives
C3348_RS07340	COG5001	Diguanylate cyclase
C3348_RS07340	COG3447	MASE1 domain protein
C3348_RS07340	COG5002	protein histidine kinase activity
C3348_RS07345	COG2203	Gaf domain
C3348_RS07345	COG2199	diguanylate cyclase activity
C3348_RS07355	COG0789	Transcriptional regulator
C3348_RS07355	COG4978	Transcriptional regulator
C3348_RS07370	COG1285	pathogenesis
C3348_RS07375	COG1335	isochorismatase
C3348_RS07405	COG0726	polysaccharide deacetylase
C3348_RS07420	COG0450	alkyl hydroperoxide reductase
C3348_RS07435	COG2720	vancomycin resistance protein
C3348_RS07440	COG3829	transcription factor binding
C3348_RS07455	COG1346	cytolysis
C3348_RS07460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3348_RS07470	COG2340	Cysteine-rich secretory protein family
C3348_RS07475	COG0726	polysaccharide deacetylase
C3348_RS07480	COG0512	Glutamine amidotransferase of anthranilate synthase
C3348_RS07485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3348_RS07490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3348_RS07500	COG0302	gtp cyclohydrolase
C3348_RS07505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3348_RS07510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3348_RS07515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3348_RS07520	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C3348_RS07525	COG0358	DNA primase activity
C3348_RS07530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3348_RS07535	COG2384	SAM-dependent methyltransferase
C3348_RS07540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3348_RS07545	COG0655	NAD(P)H dehydrogenase (quinone) activity
C3348_RS07565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS07580	COG3850	Histidine kinase
C3348_RS07580	COG5002	protein histidine kinase activity
C3348_RS07585	COG1136	(ABC) transporter
C3348_RS07585	COG0577	efflux transmembrane transporter activity
C3348_RS07615	COG1132	(ABC) transporter
C3348_RS07620	COG1132	(ABC) transporter
C3348_RS07625	COG1592	Rubrerythrin
C3348_RS07625	COG1773	rubredoxin
C3348_RS07640	COG0412	Dienelactone hydrolase
C3348_RS07670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3348_RS07715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3348_RS07720	COG2011	ABC-type metal ion transport system permease component
C3348_RS07730	COG5002	protein histidine kinase activity
C3348_RS07735	COG2094	Belongs to the DNA glycosylase MPG family
C3348_RS07740	COG1396	sequence-specific DNA binding
C3348_RS07745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3348_RS07750	COG4086	secreted protein
C3348_RS07770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3348_RS07780	COG1131	(ABC) transporter
C3348_RS07790	COG0534	Mate efflux family protein
C3348_RS07805	COG3901	Regulator of nitric oxide reductase transcription
C3348_RS07805	COG0348	domain, Protein
C3348_RS07835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3348_RS07840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3348_RS07850	COG5001	Diguanylate cyclase
C3348_RS07860	COG4978	Transcriptional regulator
C3348_RS07860	COG0789	Transcriptional regulator
C3348_RS07865	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C3348_RS07885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3348_RS07890	COG0726	polysaccharide deacetylase
C3348_RS07900	COG1773	rubredoxin
C3348_RS07900	COG1592	Rubrerythrin
C3348_RS07905	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3348_RS07910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3348_RS07915	COG0577	efflux transmembrane transporter activity
C3348_RS07920	COG1136	(ABC) transporter
C3348_RS07920	COG0577	efflux transmembrane transporter activity
C3348_RS07930	COG2205	protein histidine kinase activity
C3348_RS07935	COG0745	RESPONSE REGULATOR receiver
C3348_RS07940	COG1136	(ABC) transporter
C3348_RS07945	COG0577	efflux transmembrane transporter activity
C3348_RS07950	COG0405	Gamma-glutamyltransferase
C3348_RS07965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3348_RS07965	COG0493	'glutamate synthase
C3348_RS07975	COG1136	(ABC) transporter
C3348_RS07980	COG0577	efflux transmembrane transporter activity
C3348_RS08020	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C3348_RS08025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3348_RS08030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3348_RS08035	COG0131	Imidazoleglycerol-phosphate dehydratase
C3348_RS08040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3348_RS08045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3348_RS08050	COG0107	imidazoleglycerol-phosphate synthase activity
C3348_RS08055	COG0140	phosphoribosyl-ATP diphosphatase activity
C3348_RS08055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3348_RS08060	COG0531	amino acid
C3348_RS08075	COG1595	DNA-templated transcription, initiation
C3348_RS08090	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C3348_RS08105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3348_RS08110	COG0028	Belongs to the TPP enzyme family
C3348_RS08115	COG0582	viral genome integration into host DNA
C3348_RS08135	COG1396	sequence-specific DNA binding
C3348_RS08165	COG1476	TRANSCRIPTIONal
C3348_RS08245	COG5484	DNA packaging
C3348_RS08380	COG4193	domain, Protein
C3348_RS08390	COG3628	GPW Gp25 family protein
C3348_RS08395	COG3299	homolog of phage Mu protein gp47
C3348_RS08445	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS08445	COG1388	LysM domain
C3348_RS08460	COG3546	catalase activity
C3348_RS08465	COG1331	Highly conserved protein containing a thioredoxin domain
C3348_RS08495	COG2267	carboxylic ester hydrolase activity
C3348_RS08510	COG3584	3D domain protein
C3348_RS08510	COG1388	LysM domain
C3348_RS08520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3348_RS08525	COG1295	ribonuclease BN
C3348_RS08530	COG5002	protein histidine kinase activity
C3348_RS08535	COG0460	homoserine dehydrogenase
C3348_RS08545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3348_RS08550	COG2267	carboxylic ester hydrolase activity
C3348_RS08555	COG5566	PFAM Mor transcription activator
C3348_RS08565	COG2971	BadF BadG BcrA BcrD
C3348_RS08575	COG1129	ABC transporter
C3348_RS08580	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3348_RS08590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3348_RS08600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C3348_RS08605	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C3348_RS08610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C3348_RS08615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3348_RS08620	COG1045	serine acetyltransferase
C3348_RS08625	COG1141	Ferredoxin
C3348_RS08645	COG0351	phosphomethylpyrimidine kinase
C3348_RS08650	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C3348_RS08655	COG0352	thiamine-phosphate diphosphorylase activity
C3348_RS08660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS08680	COG1725	Transcriptional regulator
C3348_RS08720	COG4555	ABC transporter
C3348_RS08725	COG1668	transmembrane transport
C3348_RS08730	COG3300	MHYT domain
C3348_RS08730	COG5001	Diguanylate cyclase
C3348_RS08735	COG1725	Transcriptional regulator
C3348_RS08740	COG1131	(ABC) transporter
C3348_RS08755	COG0668	transmembrane transport
C3348_RS08765	COG0426	domain, Protein
C3348_RS08780	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3348_RS08785	COG1876	peptidase activity
C3348_RS08810	COG0367	asparagine synthase
C3348_RS08815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3348_RS08830	COG2310	stress, protein
C3348_RS08845	COG3853	Toxic anion resistance protein (TelA)
C3348_RS08875	COG5505	Protein of unknown function (DUF819)
C3348_RS08885	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3348_RS08890	COG4605	iron ion homeostasis
C3348_RS08895	COG4604	ABC transporter, ATP-binding protein
C3348_RS08900	COG4607	ABC-type enterochelin transport system periplasmic component
C3348_RS08905	COG2203	Gaf domain
C3348_RS08905	COG5001	Diguanylate cyclase
C3348_RS08905	COG4251	negative regulation of phosphorylation
C3348_RS08905	COG3706	GGDEF domain
C3348_RS08920	COG0095	Lipoate-protein ligase
C3348_RS08925	COG1757	Na H antiporter
C3348_RS08940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3348_RS08945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3348_RS08950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3348_RS08955	COG3123	guanosine phosphorylase activity
C3348_RS08970	COG0402	S-adenosylhomocysteine deaminase activity
C3348_RS08985	COG1396	sequence-specific DNA binding
C3348_RS08995	COG0584	glycerophosphoryl diester phosphodiesterase
C3348_RS09015	COG4555	ABC transporter
C3348_RS09025	COG0745	RESPONSE REGULATOR receiver
C3348_RS09030	COG2205	protein histidine kinase activity
C3348_RS09045	COG1733	regulation of RNA biosynthetic process
C3348_RS09050	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C3348_RS09080	COG1309	transcriptional regulator
C3348_RS09115	COG0745	RESPONSE REGULATOR receiver
C3348_RS09120	COG5002	protein histidine kinase activity
C3348_RS09125	COG3118	belongs to the thioredoxin family
C3348_RS09155	COG1115	amino acid carrier protein
C3348_RS09165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3348_RS09165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3348_RS09180	COG0514	ATP-dependent DNA helicase (RecQ)
C3348_RS09185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3348_RS09200	COG2022	thiamine diphosphate biosynthetic process
C3348_RS09205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3348_RS09215	COG1288	antiporter activity
C3348_RS09235	COG0393	Putative heavy-metal-binding
C3348_RS09240	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3348_RS09250	COG0315	cyclic pyranopterin monophosphate synthase activity
C3348_RS09325	COG1283	sodium-dependent phosphate transmembrane transporter activity
C3348_RS09350	COG5012	cobalamin binding
C3348_RS09355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3348_RS09365	COG1011	Hydrolase
C3348_RS09370	COG1396	sequence-specific DNA binding
C3348_RS09370	COG1917	Cupin 2, conserved barrel domain protein
C3348_RS09375	COG2610	gluconate transmembrane transporter activity
C3348_RS09380	COG5002	protein histidine kinase activity
C3348_RS09385	COG2204	response regulator
C3348_RS09405	COG0786	glutamate:sodium symporter activity
C3348_RS09420	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C3348_RS09425	COG1924	4 iron, 4 sulfur cluster binding
C3348_RS09430	COG2385	sporulation resulting in formation of a cellular spore
C3348_RS09430	COG2247	cell wall binding repeat
C3348_RS09440	COG1309	transcriptional regulator
C3348_RS09465	COG0242	peptide deformylase activity
C3348_RS09500	COG3326	Membrane
C3348_RS09515	COG0494	nUDIX hydrolase
C3348_RS09565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3348_RS09570	COG0765	amino acid transport
C3348_RS09580	COG1393	Belongs to the ArsC family
C3348_RS09590	COG1606	tRNA processing
C3348_RS09595	COG0116	Belongs to the methyltransferase superfamily
C3348_RS09610	COG5002	protein histidine kinase activity
C3348_RS09610	COG3850	Histidine kinase
C3348_RS09620	COG0137	argininosuccinate synthase activity
C3348_RS09630	COG0789	Transcriptional regulator
C3348_RS09640	COG2323	membrane
C3348_RS09655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3348_RS09680	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3348_RS09685	COG0583	DNA-binding transcription factor activity
C3348_RS09700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3348_RS09715	COG1609	Transcriptional regulator
C3348_RS09725	COG1621	beta-fructofuranosidase activity
C3348_RS09730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3348_RS09745	COG2814	Major facilitator Superfamily
C3348_RS09775	COG0406	alpha-ribazole phosphatase activity
C3348_RS09780	COG2081	HI0933 family
C3348_RS09785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3348_RS09790	COG0204	Acyl-transferase
C3348_RS09795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3348_RS09810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3348_RS09815	COG3022	response to hydroperoxide
C3348_RS09830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C3348_RS09835	COG1846	Transcriptional regulator
C3348_RS09840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3348_RS09845	COG2205	protein histidine kinase activity
C3348_RS09855	COG0598	Magnesium transport protein CorA
C3348_RS09865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C3348_RS09870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3348_RS09875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3348_RS09880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3348_RS09885	COG0077	Prephenate dehydratase
C3348_RS09885	COG1605	Chorismate mutase
C3348_RS09890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3348_RS09900	COG0287	Prephenate dehydrogenase
C3348_RS09910	COG3706	GGDEF domain
C3348_RS09935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3348_RS09940	COG2226	methyltransferase
C3348_RS09945	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C3348_RS09975	COG2131	deaminase
C3348_RS10000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3348_RS10050	COG4303	Ethanolamine ammonia lyase large subunit
C3348_RS10055	COG4302	ethanolamine ammonia-lyase activity
C3348_RS10070	COG1012	belongs to the aldehyde dehydrogenase family
C3348_RS10070	COG1454	alcohol dehydrogenase
C3348_RS10085	COG4869	propanediol catabolic process
C3348_RS10095	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C3348_RS10105	COG3192	ethanolamine utilization protein
C3348_RS10110	COG4766	ethanolamine catabolic process
C3348_RS10120	COG1473	amidohydrolase
C3348_RS10125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C3348_RS10130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3348_RS10135	COG1116	anion transmembrane transporter activity
C3348_RS10155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3348_RS10160	COG4974	Belongs to the 'phage' integrase family
C3348_RS10175	COG2359	stage V sporulation protein S
C3348_RS10180	COG0825	malonyl-CoA metabolic process
C3348_RS10185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3348_RS10190	COG0439	Biotin carboxylase
C3348_RS10195	COG0511	ligase activity, forming carbon-carbon bonds
C3348_RS10215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3348_RS10240	COG1136	(ABC) transporter
C3348_RS10250	COG2205	protein histidine kinase activity
C3348_RS10255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3348_RS10260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3348_RS10280	COG1136	(ABC) transporter
C3348_RS10285	COG2205	protein histidine kinase activity
C3348_RS10290	COG0745	RESPONSE REGULATOR receiver
C3348_RS10300	COG0745	RESPONSE REGULATOR receiver
C3348_RS10305	COG5002	protein histidine kinase activity
C3348_RS10310	COG1136	(ABC) transporter
C3348_RS10310	COG0577	efflux transmembrane transporter activity
C3348_RS10345	COG1811	Na channel or pump
C3348_RS10350	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C3348_RS10365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3348_RS10370	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C3348_RS10375	COG1923	regulation of RNA biosynthetic process
C3348_RS10380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3348_RS10385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3348_RS10390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3348_RS10395	COG1116	anion transmembrane transporter activity
C3348_RS10400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3348_RS10405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3348_RS10420	COG1733	regulation of RNA biosynthetic process
C3348_RS10435	COG0384	phenazine biosynthesis protein PhzF
C3348_RS10440	COG0384	phenazine biosynthesis protein PhzF
C3348_RS10445	COG0494	nUDIX hydrolase
C3348_RS10455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3348_RS10460	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS10460	COG2247	cell wall binding repeat
C3348_RS10520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3348_RS10540	COG0730	response to heat
C3348_RS10545	COG2207	Transcriptional regulator
C3348_RS10550	COG0789	Transcriptional regulator
C3348_RS10565	COG1404	Belongs to the peptidase S8 family
C3348_RS10570	COG0129	dihydroxy-acid dehydratase activity
C3348_RS10600	COG2207	Transcriptional regulator
C3348_RS10605	COG2814	Major facilitator Superfamily
C3348_RS10625	COG1725	Transcriptional regulator
C3348_RS10650	COG1794	racemase activity, acting on amino acids and derivatives
C3348_RS10660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3348_RS10665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3348_RS10670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3348_RS10675	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3348_RS10685	COG0456	acetyltransferase
C3348_RS10695	COG1309	transcriptional regulator
C3348_RS10720	COG3655	Transcriptional regulator
C3348_RS10735	COG1737	Transcriptional regulator
C3348_RS10740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C3348_RS10745	COG1187	pseudouridine synthase activity
C3348_RS10750	COG0628	permease
C3348_RS10760	COG0019	diaminopimelate decarboxylase activity
C3348_RS10765	COG0527	aspartate kinase activity
C3348_RS10795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3348_RS10800	COG1597	lipid kinase activity
C3348_RS10830	COG0582	viral genome integration into host DNA
C3348_RS10840	COG0488	(ABC) transporter
C3348_RS10855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3348_RS10865	COG2080	2 iron, 2 sulfur cluster binding
C3348_RS10865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3348_RS10875	COG2233	PERMEase
C3348_RS10890	COG0167	dihydroorotate dehydrogenase activity
C3348_RS10895	COG0402	S-adenosylhomocysteine deaminase activity
C3348_RS10915	COG0402	S-adenosylhomocysteine deaminase activity
C3348_RS10940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3348_RS10965	COG3829	transcription factor binding
C3348_RS10975	COG1401	restriction endodeoxyribonuclease activity
C3348_RS10990	COG4708	membrane
C3348_RS11000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3348_RS11000	COG2080	2 iron, 2 sulfur cluster binding
C3348_RS11035	COG1131	(ABC) transporter
C3348_RS11045	COG2252	PERMEase
C3348_RS11050	COG0534	Mate efflux family protein
C3348_RS11060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3348_RS11065	COG1349	DNA-binding transcription factor activity
C3348_RS11075	COG5002	protein histidine kinase activity
C3348_RS11080	COG0745	RESPONSE REGULATOR receiver
C3348_RS11085	COG2217	Heavy metal translocating P-type atpase
C3348_RS11100	COG1217	gtp-binding protein TYPA
C3348_RS11105	COG0492	ferredoxin-NADP+ reductase activity
C3348_RS11145	COG1247	-acetyltransferase
C3348_RS11170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3348_RS11175	COG0750	zinc metalloprotease
C3348_RS11180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3348_RS11205	COG4589	Belongs to the CDS family
C3348_RS11220	COG0233	cytoplasmic translational termination
C3348_RS11225	COG0528	UMP kinase activity
C3348_RS11230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3348_RS11235	COG0052	Belongs to the universal ribosomal protein uS2 family
C3348_RS11240	COG1686	Belongs to the peptidase S11 family
C3348_RS11255	COG1971	Probably functions as a manganese efflux pump
C3348_RS11260	COG1193	negative regulation of DNA recombination
C3348_RS11275	COG2720	vancomycin resistance protein
C3348_RS11295	COG1363	Peptidase, m42
C3348_RS11305	COG1160	GTP binding
C3348_RS11310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3348_RS11360	COG0039	L-malate dehydrogenase activity
C3348_RS11370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3348_RS11370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3348_RS11380	COG1151	hydroxylamine reductase activity
C3348_RS11400	COG1301	dicarboxylic acid transport
C3348_RS11405	COG1126	abc transporter atp-binding protein
C3348_RS11430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3348_RS11435	COG0437	4 iron, 4 sulfur cluster binding
C3348_RS11445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3348_RS11450	COG0596	Alpha beta hydrolase
C3348_RS11455	COG0513	Belongs to the DEAD box helicase family
C3348_RS11480	COG1705	Flagellar rod assembly protein muramidase FlgJ
C3348_RS11485	COG1554	hydrolase, family 65, central catalytic
C3348_RS11490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3348_RS11500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3348_RS11510	COG2385	sporulation resulting in formation of a cellular spore
C3348_RS11510	COG2247	cell wall binding repeat
C3348_RS11520	COG1528	Iron-storage protein
C3348_RS11540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C3348_RS11540	COG0674	pyruvate-flavodoxin oxidoreductase activity
C3348_RS11550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3348_RS11565	COG1309	transcriptional regulator
C3348_RS11575	COG0628	permease
C3348_RS11580	COG1012	belongs to the aldehyde dehydrogenase family
C3348_RS11595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3348_RS11620	COG0288	reversible hydration of carbon dioxide
C3348_RS11640	COG0710	3-dehydroquinate dehydratase activity
C3348_RS11655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3348_RS11715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3348_RS11720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3348_RS11725	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C3348_RS11740	COG5001	Diguanylate cyclase
C3348_RS11740	COG2203	Gaf domain
C3348_RS11740	COG4251	negative regulation of phosphorylation
C3348_RS11740	COG3706	GGDEF domain
C3348_RS11745	COG0017	Asparaginyl-tRNA synthetase
C3348_RS11755	COG1404	Belongs to the peptidase S8 family
C3348_RS11760	COG1404	Belongs to the peptidase S8 family
C3348_RS11770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3348_RS11785	COG1509	lysine 2,3-aminomutase activity
C3348_RS11790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS11795	COG1794	racemase activity, acting on amino acids and derivatives
C3348_RS11815	COG0662	Cupin 2, conserved barrel domain protein
C3348_RS11820	COG3104	oligopeptide transport
C3348_RS11825	COG0006	proline dipeptidase activity
C3348_RS11830	COG3104	oligopeptide transport
C3348_RS11835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3348_RS11850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3348_RS11850	COG0723	plastoquinol--plastocyanin reductase activity
C3348_RS11860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS11860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS11860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS11865	COG1105	Belongs to the carbohydrate kinase PfkB family
C3348_RS11870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS11870	COG3711	transcriptional antiterminator
C3348_RS11875	COG2365	Tyrosine phosphatase family
C3348_RS11895	COG1115	amino acid carrier protein
C3348_RS11900	COG0235	Class ii aldolase
C3348_RS11905	COG0235	Class ii aldolase
C3348_RS11910	COG1063	alcohol dehydrogenase
C3348_RS11915	COG3775	system Galactitol-specific IIC component
C3348_RS11920	COG3414	Phosphotransferase system galactitol-specific IIB component
C3348_RS11925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS11925	COG2213	PTS system mannitol-specific
C3348_RS11930	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3348_RS11930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3348_RS11950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS11955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C3348_RS11965	COG5002	protein histidine kinase activity
C3348_RS12010	COG3620	sequence-specific DNA binding
C3348_RS12015	COG2801	Transposase and inactivated derivatives
C3348_RS12045	COG3842	ATPase activity
C3348_RS12065	COG2205	protein histidine kinase activity
C3348_RS12075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3348_RS12080	COG0698	ribose 5-phosphate isomerase
C3348_RS12085	COG3958	Transketolase
C3348_RS12090	COG3959	Transketolase, thiamine diphosphate binding domain
C3348_RS12105	COG3775	system Galactitol-specific IIC component
C3348_RS12110	COG3414	Phosphotransferase system galactitol-specific IIB component
C3348_RS12120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3348_RS12120	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3348_RS12125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3348_RS12130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3348_RS12135	COG0246	Mannitol dehydrogenase
C3348_RS12140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS12145	COG3711	transcriptional antiterminator
C3348_RS12155	COG0517	IMP dehydrogenase activity
C3348_RS12155	COG0516	GMP reductase activity
C3348_RS12160	COG3853	Toxic anion resistance protein (TelA)
C3348_RS12170	COG1454	alcohol dehydrogenase
C3348_RS12175	COG0427	acetyl-CoA hydrolase
C3348_RS12190	COG1012	belongs to the aldehyde dehydrogenase family
C3348_RS12195	COG0427	acetyl-CoA hydrolase
C3348_RS12200	COG2985	domain, Protein
C3348_RS12200	COG0490	domain, Protein
C3348_RS12200	COG0490	domain, Protein
C3348_RS12200	COG2985	domain, Protein
C3348_RS12205	COG0583	DNA-binding transcription factor activity
C3348_RS12215	COG0006	proline dipeptidase activity
C3348_RS12245	COG3118	belongs to the thioredoxin family
C3348_RS12280	COG1116	anion transmembrane transporter activity
C3348_RS12290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3348_RS12330	COG0157	Belongs to the NadC ModD family
C3348_RS12340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3348_RS12345	COG1966	Carbon starvation protein
C3348_RS12360	COG0628	permease
C3348_RS12370	COG2364	Membrane
C3348_RS12375	COG3426	butyrate kinase activity
C3348_RS12400	COG2199	diguanylate cyclase activity
C3348_RS12405	COG2203	Gaf domain
C3348_RS12405	COG2199	diguanylate cyclase activity
C3348_RS12460	COG0072	phenylalanine-tRNA ligase activity
C3348_RS12460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3348_RS12465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3348_RS12470	COG2176	DNA-directed DNA polymerase activity
C3348_RS12490	COG0037	tRNA processing
C3348_RS12505	COG3546	catalase activity
C3348_RS12510	COG0791	NLP P60 protein
C3348_RS12510	COG1388	LysM domain
C3348_RS12510	COG3103	Sh3 type 3 domain protein
C3348_RS12520	COG0551	DNA topoisomerase type I activity
C3348_RS12520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3348_RS12545	COG2801	Transposase and inactivated derivatives
C3348_RS12560	COG0574	Belongs to the PEP-utilizing enzyme family
C3348_RS12560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3348_RS12565	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C3348_RS12570	COG0517	IMP dehydrogenase activity
C3348_RS12590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS12590	COG3711	transcriptional antiterminator
C3348_RS12595	COG3732	PTS system glucitol sorbitol-specific
C3348_RS12605	COG2207	Transcriptional regulator
C3348_RS12620	COG1115	amino acid carrier protein
C3348_RS12625	COG2223	nitrite transmembrane transporter activity
C3348_RS12630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS12635	COG0280	phosphate acetyltransferase
C3348_RS12655	COG0674	pyruvate-flavodoxin oxidoreductase activity
C3348_RS12655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C3348_RS12665	COG1414	Transcriptional regulator
C3348_RS12675	COG0751	glycine-tRNA ligase activity
C3348_RS12680	COG0752	glycyl-tRNA synthetase alpha subunit
C3348_RS12690	COG1381	Involved in DNA repair and RecF pathway recombination
C3348_RS12700	COG2239	Acts as a magnesium transporter
C3348_RS12705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3348_RS12710	COG0295	cytidine deaminase activity
C3348_RS12715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C3348_RS12720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3348_RS12725	COG1702	phosphate starvation-inducible protein PhoH
C3348_RS12745	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C3348_RS12750	COG1610	YqeY-like protein
C3348_RS12755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3348_RS12760	COG0537	adenosine 5'-monophosphoramidase activity
C3348_RS12765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3348_RS12770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C3348_RS12775	COG2264	protein methyltransferase activity
C3348_RS12805	COG3842	ATPase activity
C3348_RS12810	COG2508	Transcriptional regulator
C3348_RS12815	COG0477	Major facilitator Superfamily
C3348_RS12830	COG0484	heat shock protein binding
C3348_RS12835	COG0443	Heat shock 70 kDa protein
C3348_RS12840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3348_RS12845	COG1420	regulation of RNA biosynthetic process
C3348_RS12850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3348_RS12855	COG0531	amino acid
C3348_RS12860	COG0617	tRNA 3'-terminal CCA addition
C3348_RS12865	COG0481	GTPase activity
C3348_RS12895	COG0268	Binds directly to 16S ribosomal RNA
C3348_RS12905	COG2333	competence protein COMEC
C3348_RS12905	COG0658	competence protein
C3348_RS12925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3348_RS12930	COG1388	LysM domain
C3348_RS12930	COG3584	3D domain protein
C3348_RS12935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3348_RS12950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3348_RS12955	COG0006	proline dipeptidase activity
C3348_RS12960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS12965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS12975	COG3711	transcriptional antiterminator
C3348_RS12975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS12980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3348_RS12985	COG1482	cell wall glycoprotein biosynthetic process
C3348_RS12990	COG5002	protein histidine kinase activity
C3348_RS13010	COG1555	photosystem II stabilization
C3348_RS13015	COG1686	Belongs to the peptidase S11 family
C3348_RS13025	COG0165	Argininosuccinate lyase
C3348_RS13030	COG0561	phosphatase activity
C3348_RS13035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3348_RS13040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3348_RS13045	COG1876	peptidase activity
C3348_RS13050	COG1309	transcriptional regulator
C3348_RS13055	COG2814	Major facilitator Superfamily
C3348_RS13065	COG4977	sequence-specific DNA binding
C3348_RS13070	COG1486	melibiose metabolic process
C3348_RS13075	COG1263	PTS System
C3348_RS13075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS13080	COG3711	transcriptional antiterminator
C3348_RS13085	COG2190	(PTS) system
C3348_RS13090	COG0251	oxidation-reduction process
C3348_RS13095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3348_RS13120	COG0495	leucyl-tRNA aminoacylation
C3348_RS13125	COG0799	negative regulation of ribosome biogenesis
C3348_RS13130	COG1713	HD superfamily hydrolase involved in NAD metabolism
C3348_RS13135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3348_RS13140	COG2137	regulation of response to DNA damage stimulus
C3348_RS13145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3348_RS13165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3348_RS13175	COG0577	efflux transmembrane transporter activity
C3348_RS13175	COG1136	(ABC) transporter
C3348_RS13185	COG0745	RESPONSE REGULATOR receiver
C3348_RS13190	COG0737	Belongs to the 5'-nucleotidase family
C3348_RS13200	COG1234	tRNA 3'-trailer cleavage
C3348_RS13205	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3348_RS13210	COG1823	symporter activity
C3348_RS13235	COG4124	Belongs to the glycosyl hydrolase 26 family
C3348_RS13235	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C3348_RS13245	COG0395	ABC-type sugar transport system, permease component
C3348_RS13265	COG4821	SIS domain
C3348_RS13295	COG0742	ribosomal rna small subunit methyltransferase
C3348_RS13300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3348_RS13305	COG1461	Dihydroxyacetone kinase
C3348_RS13310	COG1302	Protein conserved in bacteria
C3348_RS13315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3348_RS13330	COG0789	Transcriptional regulator
C3348_RS13335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS13335	COG3711	transcriptional antiterminator
C3348_RS13340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS13340	COG3711	transcriptional antiterminator
C3348_RS13345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS13350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS13355	COG0383	alpha-mannosidase activity
C3348_RS13380	COG1564	THIamine pyrophosphokinase
C3348_RS13385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3348_RS13390	COG1162	GTPase activity
C3348_RS13395	COG1028	Short-chain dehydrogenase reductase Sdr
C3348_RS13400	COG0515	serine threonine protein kinase
C3348_RS13400	COG2815	serine threonine protein kinase
C3348_RS13410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3348_RS13415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3348_RS13415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3348_RS13420	COG2738	Putative neutral zinc metallopeptidase
C3348_RS13430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3348_RS13435	COG0242	peptide deformylase activity
C3348_RS13440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3348_RS13445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3348_RS13450	COG1758	RNA polymerase activity
C3348_RS13455	COG0194	GDP metabolic process
C3348_RS13460	COG1561	YicC-like family, N-terminal region
C3348_RS13465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3348_RS13475	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C3348_RS13480	COG0488	(ABC) transporter
C3348_RS13490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3348_RS13495	COG0564	pseudouridine synthase activity
C3348_RS13500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3348_RS13510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3348_RS13515	COG1966	Carbon starvation protein
C3348_RS13520	COG3279	Response regulator of the LytR AlgR family
C3348_RS13525	COG3275	phosphorelay sensor kinase activity
C3348_RS13550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3348_RS13555	COG0531	amino acid
C3348_RS13560	COG0006	proline dipeptidase activity
C3348_RS13565	COG1307	EDD domain protein, DegV family
C3348_RS13580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3348_RS13595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3348_RS13605	COG2302	S4 RNA-binding domain
C3348_RS13615	COG1799	cell septum assembly
C3348_RS13620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3348_RS13640	COG3830	Belongs to the UPF0237 family
C3348_RS13650	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C3348_RS13655	COG2271	Major facilitator Superfamily
C3348_RS13660	COG0531	amino acid
C3348_RS13665	COG0006	proline dipeptidase activity
C3348_RS13675	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3348_RS13680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3348_RS13685	COG1160	GTP binding
C3348_RS13710	COG5002	protein histidine kinase activity
C3348_RS13715	COG0745	RESPONSE REGULATOR receiver
C3348_RS13725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3348_RS13730	COG1873	PFAM PRC-barrel domain
C3348_RS13735	COG1191	sigma factor activity
C3348_RS13740	COG1191	sigma factor activity
C3348_RS13755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3348_RS13760	COG3856	small basic protein
C3348_RS13780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3348_RS13785	COG0772	Belongs to the SEDS family
C3348_RS13790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3348_RS13795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3348_RS13800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3348_RS13805	COG0768	penicillin binding
C3348_RS13815	COG0275	rRNA processing
C3348_RS13820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3348_RS13825	COG0612	Peptidase, M16
C3348_RS13835	COG0012	GTP binding
C3348_RS13845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3348_RS13855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS13855	COG2190	(PTS) system
C3348_RS13855	COG1263	PTS System
C3348_RS13860	COG3711	transcriptional antiterminator
C3348_RS13865	COG0025	NhaP-type Na H and K H
C3348_RS13870	COG4608	Belongs to the ABC transporter superfamily
C3348_RS13875	COG0444	Belongs to the ABC transporter superfamily
C3348_RS13885	COG0601	transmembrane transport
C3348_RS13890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3348_RS13895	COG0583	DNA-binding transcription factor activity
C3348_RS13900	COG0183	Belongs to the thiolase family
C3348_RS13905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C3348_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
C3348_RS13920	COG2610	gluconate transmembrane transporter activity
C3348_RS13925	COG2340	Cysteine-rich secretory protein family
C3348_RS13940	COG4869	propanediol catabolic process
C3348_RS13975	COG2081	HI0933 family
C3348_RS13980	COG0671	phosphoesterase, PA-phosphatase related
C3348_RS13990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3348_RS14005	COG2502	aspartate--ammonia ligase
C3348_RS14010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3348_RS14015	COG1473	amidohydrolase
C3348_RS14025	COG3366	ferrous iron transmembrane transporter activity
C3348_RS14050	COG2252	PERMEase
C3348_RS14055	COG0402	S-adenosylhomocysteine deaminase activity
C3348_RS14065	COG2271	Major facilitator Superfamily
C3348_RS14085	COG0583	DNA-binding transcription factor activity
C3348_RS14095	COG1376	ErfK ybiS ycfS ynhG family protein
C3348_RS14100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3348_RS14105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3348_RS14130	COG4509	Sortase family
C3348_RS14150	COG0726	polysaccharide deacetylase
C3348_RS14155	COG3069	C4-dicarboxylate transmembrane transporter activity
C3348_RS14160	COG0642	Histidine kinase
C3348_RS14160	COG5002	protein histidine kinase activity
C3348_RS14165	COG0745	RESPONSE REGULATOR receiver
C3348_RS14180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3348_RS14185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3348_RS14205	COG1937	Protein conserved in bacteria
C3348_RS14220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3348_RS14225	COG1757	Na H antiporter
C3348_RS14235	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS14235	COG2247	cell wall binding repeat
C3348_RS14240	COG0583	DNA-binding transcription factor activity
C3348_RS14245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3348_RS14255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3348_RS14260	COG0124	histidyl-tRNA synthetase
C3348_RS14265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3348_RS14270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3348_RS14275	COG1490	D-aminoacyl-tRNA deacylase activity
C3348_RS14280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3348_RS14285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3348_RS14290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3348_RS14290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C3348_RS14335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS14360	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS14365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3348_RS14375	COG0561	phosphatase activity
C3348_RS14380	COG1316	TRANSCRIPTIONal
C3348_RS14385	COG1316	TRANSCRIPTIONal
C3348_RS14390	COG1649	PFAM Uncharacterised BCR, COG1649
C3348_RS14395	COG0791	NLP P60 protein
C3348_RS14405	COG0438	transferase activity, transferring glycosyl groups
C3348_RS14410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3348_RS14415	COG1215	transferase activity, transferring glycosyl groups
C3348_RS14425	COG1215	transferase activity, transferring glycosyl groups
C3348_RS14430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3348_RS14430	COG1215	transferase activity, transferring glycosyl groups
C3348_RS14435	COG1215	transferase activity, transferring glycosyl groups
C3348_RS14455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3348_RS14460	COG0728	peptidoglycan biosynthetic process
C3348_RS14465	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS14465	COG2247	cell wall binding repeat
C3348_RS14470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3348_RS14475	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS14490	COG2247	cell wall binding repeat
C3348_RS14490	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS14500	COG2246	polysaccharide biosynthetic process
C3348_RS14505	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS14505	COG2247	cell wall binding repeat
C3348_RS14520	COG0653	protein targeting
C3348_RS14555	COG2247	cell wall binding repeat
C3348_RS14555	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS14575	COG0343	queuine tRNA-ribosyltransferase activity
C3348_RS14585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3348_RS14590	COG2255	four-way junction helicase activity
C3348_RS14595	COG0632	four-way junction helicase activity
C3348_RS14600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3348_RS14625	COG2610	gluconate transmembrane transporter activity
C3348_RS14630	COG2084	Dehydrogenase
C3348_RS14650	COG1132	(ABC) transporter
C3348_RS14665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3348_RS14675	COG2801	Transposase and inactivated derivatives
C3348_RS14685	COG0700	Nucleoside recognition
C3348_RS14690	COG3366	ferrous iron transmembrane transporter activity
C3348_RS14695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3348_RS14740	COG0436	Aminotransferase
C3348_RS14745	COG0697	spore germination
C3348_RS14760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3348_RS14775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3348_RS14780	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C3348_RS14785	COG1473	amidohydrolase
C3348_RS14790	COG3949	Membrane
C3348_RS14805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3348_RS14820	COG0604	alcohol dehydrogenase
C3348_RS14830	COG1592	Rubrerythrin
C3348_RS14835	COG0789	Transcriptional regulator
C3348_RS14845	COG1664	Polymer-forming cytoskeletal
C3348_RS14850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3348_RS14850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3348_RS14855	COG1349	DNA-binding transcription factor activity
C3348_RS14860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3348_RS14865	COG1696	Membrane protein involved in D-alanine export
C3348_RS14870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3348_RS14880	COG0673	inositol 2-dehydrogenase activity
C3348_RS14890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3348_RS14895	COG1253	flavin adenine dinucleotide binding
C3348_RS14900	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C3348_RS14920	COG3290	protein histidine kinase activity
C3348_RS14920	COG3829	transcription factor binding
C3348_RS14925	COG2267	carboxylic ester hydrolase activity
C3348_RS14935	COG0577	efflux transmembrane transporter activity
C3348_RS14940	COG1136	(ABC) transporter
C3348_RS14955	COG0745	RESPONSE REGULATOR receiver
C3348_RS14960	COG0312	modulator of DNA gyrase
C3348_RS14965	COG0312	modulator of DNA gyrase
C3348_RS14990	COG2721	sulfolactate sulfo-lyase activity
C3348_RS15005	COG1120	ATPase activity
C3348_RS15010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3348_RS15015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3348_RS15030	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3348_RS15035	COG3394	polysaccharide catabolic process
C3348_RS15040	COG1486	melibiose metabolic process
C3348_RS15045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS15055	COG2188	Transcriptional regulator
C3348_RS15060	COG0534	Mate efflux family protein
C3348_RS15065	COG2199	diguanylate cyclase activity
C3348_RS15070	COG1178	ABC-type Fe3 transport system permease component
C3348_RS15075	COG3842	ATPase activity
C3348_RS15080	COG1840	ABC-type Fe3 transport system, periplasmic component
C3348_RS15085	COG1394	ATPase activity, coupled to movement of substances
C3348_RS15090	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C3348_RS15095	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C3348_RS15110	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C3348_RS15115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3348_RS15120	COG1269	ATP hydrolysis coupled proton transport
C3348_RS15145	COG5001	Diguanylate cyclase
C3348_RS15145	COG3300	MHYT domain
C3348_RS15150	COG1012	belongs to the aldehyde dehydrogenase family
C3348_RS15150	COG1454	alcohol dehydrogenase
C3348_RS15160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3348_RS15170	COG0318	PFAM AMP-dependent synthetase and ligase
C3348_RS15175	COG0183	Belongs to the thiolase family
C3348_RS15180	COG1268	BioY protein
C3348_RS15195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C3348_RS15210	COG1203	CRISPR-associated helicase, Cas3
C3348_RS15240	COG0577	efflux transmembrane transporter activity
C3348_RS15245	COG1136	(ABC) transporter
C3348_RS15250	COG1968	undecaprenyl-diphosphatase activity
C3348_RS15255	COG2205	protein histidine kinase activity
C3348_RS15260	COG0745	RESPONSE REGULATOR receiver
C3348_RS15275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3348_RS15290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3348_RS15295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3348_RS15305	COG1120	ATPase activity
C3348_RS15310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3348_RS15330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3348_RS15340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3348_RS15345	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3348_RS15370	COG1454	alcohol dehydrogenase
C3348_RS15375	COG1376	ErfK ybiS ycfS ynhG family protein
C3348_RS15385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3348_RS15390	COG0785	Cytochrome C biogenesis protein
C3348_RS15395	COG1733	regulation of RNA biosynthetic process
C3348_RS15400	COG0383	alpha-mannosidase activity
C3348_RS15405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS15415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS15420	COG3711	transcriptional antiterminator
C3348_RS15425	COG4975	Glucose uptake
C3348_RS15460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3348_RS15475	COG0517	IMP dehydrogenase activity
C3348_RS15475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3348_RS15480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3348_RS15485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS15485	COG1263	PTS System
C3348_RS15490	COG3711	transcriptional antiterminator
C3348_RS15495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3348_RS15500	COG3118	belongs to the thioredoxin family
C3348_RS15510	COG0384	phenazine biosynthesis protein PhzF
C3348_RS15530	COG0542	response to heat
C3348_RS15540	COG2267	carboxylic ester hydrolase activity
C3348_RS15555	COG1737	Transcriptional regulator
C3348_RS15560	COG2971	BadF BadG BcrA BcrD
C3348_RS15565	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C3348_RS15575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS15590	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C3348_RS15600	COG0642	Histidine kinase
C3348_RS15615	COG1136	(ABC) transporter
C3348_RS15625	COG2190	(PTS) system
C3348_RS15640	COG1263	PTS System
C3348_RS15640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS15655	COG2115	Belongs to the xylose isomerase family
C3348_RS15660	COG1070	Carbohydrate kinase
C3348_RS15675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS15675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS15680	COG3716	PTS system mannose fructose sorbose family IID component
C3348_RS15710	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C3348_RS15735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C3348_RS15740	COG0191	fructose-bisphosphate aldolase activity
C3348_RS15745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS15745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15760	COG2364	Membrane
C3348_RS15765	COG2723	6-phospho-beta-galactosidase activity
C3348_RS15775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS15780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS15785	COG2213	PTS system mannitol-specific
C3348_RS15785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS15790	COG1929	Belongs to the glycerate kinase type-1 family
C3348_RS15795	COG0383	alpha-mannosidase activity
C3348_RS15800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS15800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS15810	COG3394	polysaccharide catabolic process
C3348_RS15815	COG1263	PTS System
C3348_RS15815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS15815	COG2190	(PTS) system
C3348_RS15820	COG2188	Transcriptional regulator
C3348_RS15825	COG0366	Alpha amylase catalytic
C3348_RS15835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3348_RS15850	COG2723	6-phospho-beta-galactosidase activity
C3348_RS15855	COG1263	PTS System
C3348_RS15855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS15855	COG2190	(PTS) system
C3348_RS15860	COG3711	transcriptional antiterminator
C3348_RS15870	COG1288	antiporter activity
C3348_RS15875	COG1263	PTS System
C3348_RS15875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS15880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3348_RS15890	COG0561	phosphatase activity
C3348_RS15895	COG1454	alcohol dehydrogenase
C3348_RS15900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3348_RS15905	COG3711	transcriptional antiterminator
C3348_RS15905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS15910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3348_RS15915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3348_RS15920	COG0205	6-phosphofructokinase activity
C3348_RS15950	COG1473	amidohydrolase
C3348_RS15955	COG1473	amidohydrolase
C3348_RS15965	COG2723	6-phospho-beta-galactosidase activity
C3348_RS15970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS15970	COG1263	PTS System
C3348_RS15970	COG2190	(PTS) system
C3348_RS15985	COG1819	glycosyl
C3348_RS16040	COG2223	nitrite transmembrane transporter activity
C3348_RS16045	COG1695	Transcriptional regulator
C3348_RS16055	COG0640	Transcriptional regulator
C3348_RS16065	COG2723	6-phospho-beta-galactosidase activity
C3348_RS16070	COG2190	(PTS) system
C3348_RS16070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS16070	COG1263	PTS System
C3348_RS16075	COG3711	transcriptional antiterminator
C3348_RS16080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS16080	COG1263	PTS System
C3348_RS16085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3348_RS16095	COG2723	6-phospho-beta-galactosidase activity
C3348_RS16105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS16105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS16105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS16110	COG3711	transcriptional antiterminator
C3348_RS16115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS16115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3348_RS16115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS16120	COG0191	fructose-bisphosphate aldolase activity
C3348_RS16125	COG1178	ABC-type Fe3 transport system permease component
C3348_RS16130	COG3842	ATPase activity
C3348_RS16145	COG1840	ABC-type Fe3 transport system, periplasmic component
C3348_RS16160	COG0693	protein deglycase activity
C3348_RS16210	COG2801	Transposase and inactivated derivatives
C3348_RS16275	COG0305	Participates in initiation and elongation during chromosome replication
C3348_RS16295	COG3620	sequence-specific DNA binding
C3348_RS16315	COG0582	viral genome integration into host DNA
C3348_RS16350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3348_RS16375	COG1131	(ABC) transporter
C3348_RS16385	COG0557	exoribonuclease II activity
C3348_RS16400	COG1881	PFAM PEBP family protein
C3348_RS16430	COG0148	phosphopyruvate hydratase activity
C3348_RS16435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C3348_RS16440	COG0149	triose-phosphate isomerase activity
C3348_RS16445	COG0126	phosphoglycerate kinase activity
C3348_RS16455	COG2390	Transcriptional regulator
C3348_RS16460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C3348_RS16465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3348_RS16475	COG0167	dihydroorotate dehydrogenase activity
C3348_RS16485	COG0402	S-adenosylhomocysteine deaminase activity
C3348_RS16490	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C3348_RS16510	COG3829	transcription factor binding
C3348_RS16515	COG0251	oxidation-reduction process
C3348_RS16530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3348_RS16535	COG0789	Transcriptional regulator
C3348_RS16545	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3348_RS16545	COG2247	cell wall binding repeat
C3348_RS16550	COG1136	(ABC) transporter
C3348_RS16555	COG0577	efflux transmembrane transporter activity
C3348_RS16575	COG2207	Transcriptional regulator
C3348_RS16580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3348_RS16590	COG0789	Transcriptional regulator
C3348_RS16615	COG2205	protein histidine kinase activity
C3348_RS16615	COG2770	Histidine kinase
C3348_RS16620	COG0745	RESPONSE REGULATOR receiver
C3348_RS16625	COG0706	membrane insertase activity
C3348_RS16635	COG0778	Nitroreductase
C3348_RS16645	COG0534	Mate efflux family protein
C3348_RS16670	COG2226	methyltransferase
C3348_RS16690	COG1732	Glycine betaine
C3348_RS16695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3348_RS16705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C3348_RS16710	COG2226	methyltransferase
C3348_RS16720	COG1473	amidohydrolase
C3348_RS16725	COG1760	l-serine dehydratase
C3348_RS16735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3348_RS16740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3348_RS16745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3348_RS16750	COG2171	N-acyltransferase activity
C3348_RS16760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3348_RS16770	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C3348_RS16775	COG3681	Belongs to the UPF0597 family
C3348_RS16785	COG3829	transcription factor binding
C3348_RS16790	COG2226	methyltransferase
C3348_RS16815	COG0252	asparaginase activity
C3348_RS16815	COG5275	peptidyl-tyrosine sulfation
C3348_RS16820	COG0252	asparaginase activity
C3348_RS16820	COG5275	peptidyl-tyrosine sulfation
C3348_RS16835	COG0252	asparaginase activity
C3348_RS16835	COG5275	peptidyl-tyrosine sulfation
C3348_RS16855	COG4656	Part of a membrane complex involved in electron transport
C3348_RS16865	COG0726	polysaccharide deacetylase
C3348_RS16890	COG0285	dihydrofolate synthase activity
C3348_RS16900	COG3279	Response regulator of the LytR AlgR family
C3348_RS16905	COG0525	valine-tRNA ligase activity
C3348_RS16915	COG0726	polysaccharide deacetylase
C3348_RS16930	COG0704	Plays a role in the regulation of phosphate uptake
C3348_RS16935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3348_RS16940	COG0581	inorganic phosphate transmembrane transporter activity
C3348_RS16945	COG0573	inorganic phosphate transmembrane transporter activity
C3348_RS16955	COG1131	(ABC) transporter
C3348_RS16980	COG0745	RESPONSE REGULATOR receiver
C3348_RS16985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3348_RS16990	COG1164	Oligoendopeptidase f
C3348_RS16995	COG1285	pathogenesis
C3348_RS17020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C3348_RS17025	COG3716	PTS system mannose fructose sorbose family IID component
C3348_RS17030	COG3715	PTS system
C3348_RS17035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3348_RS17035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3348_RS17050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3348_RS17065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3348_RS17070	COG0166	Belongs to the GPI family
C3348_RS17075	COG1283	sodium-dependent phosphate transmembrane transporter activity
C3348_RS17080	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C3348_RS17095	COG3012	SEC-C Motif Domain Protein
C3348_RS17095	COG1405	negative regulation of cell septum assembly
C3348_RS17120	COG1459	type II secretion system
C3348_RS17125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3348_RS17140	COG2814	Major facilitator Superfamily
C3348_RS17145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C3348_RS17150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3348_RS17160	COG2059	Chromate
C3348_RS17165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3348_RS17170	COG0740	serine-type endopeptidase activity
C3348_RS17175	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3348_RS17190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3348_RS17210	COG0493	'glutamate synthase
C3348_RS17210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3348_RS17220	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3348_RS17230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3348_RS17265	COG1131	(ABC) transporter
C3348_RS17290	COG3279	Response regulator of the LytR AlgR family
C3348_RS17320	COG0457	Tetratricopeptide repeat
C3348_RS17320	COG0463	Glycosyl transferase, family 2
C3348_RS17335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS17345	COG0778	Nitroreductase
C3348_RS17350	COG1733	regulation of RNA biosynthetic process
C3348_RS17355	COG0693	protein deglycase activity
C3348_RS17360	COG1522	sequence-specific DNA binding
C3348_RS17365	COG0488	(ABC) transporter
C3348_RS17370	COG0745	RESPONSE REGULATOR receiver
C3348_RS17390	COG4555	ABC transporter
C3348_RS17395	COG2199	diguanylate cyclase activity
C3348_RS17455	COG5002	protein histidine kinase activity
C3348_RS17470	COG1136	(ABC) transporter
C3348_RS17480	COG0348	domain, Protein
C3348_RS17480	COG3901	Regulator of nitric oxide reductase transcription
C3348_RS17490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3348_RS17500	COG3843	relaxase mobilization nuclease domain protein
C3348_RS17545	COG0551	DNA topoisomerase type I activity
C3348_RS17545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3348_RS17610	COG3279	Response regulator of the LytR AlgR family
C3348_RS17625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3348_RS17670	COG0358	DNA primase activity
C3348_RS17725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3348_RS17735	COG0205	6-phosphofructokinase activity
C3348_RS17745	COG1481	regulation of sporulation
C3348_RS17760	COG1660	Displays ATPase and GTPase activities
C3348_RS17770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3348_RS17775	COG2116	formate transmembrane transporter activity
C3348_RS17780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3348_RS17810	COG0322	excinuclease ABC activity
C3348_RS17820	COG0556	nucleotide-excision repair
C3348_RS17830	COG1653	transport
C3348_RS17840	COG1175	transmembrane transport
C3348_RS17845	COG3842	ATPase activity
C3348_RS17865	COG1648	precorrin-2 dehydrogenase activity
C3348_RS17865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3348_RS17870	COG0113	porphobilinogen synthase activity
C3348_RS17880	COG0181	hydroxymethylbilane synthase activity
C3348_RS17890	COG2099	Precorrin-6x reductase
C3348_RS17920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C3348_RS17935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3348_RS17945	COG1797	cobyrinic acid a,c-diamide synthase activity
C3348_RS17950	COG1492	cobalamin metabolic process
C3348_RS17955	COG0406	alpha-ribazole phosphatase activity
C3348_RS17960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C3348_RS17965	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C3348_RS17970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3348_RS17990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3348_RS18005	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS18010	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3348_RS18015	COG1363	Peptidase, m42
C3348_RS18020	COG3711	transcriptional antiterminator
C3348_RS18025	COG0191	fructose-bisphosphate aldolase activity
C3348_RS18030	COG2222	sugar isomerase
C3348_RS18045	COG2188	Transcriptional regulator
C3348_RS18085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3348_RS18150	COG3328	transposase activity
C3348_RS18155	COG0793	Belongs to the peptidase S41A family
C3348_RS18155	COG3409	Peptidoglycan-binding domain 1 protein
C3348_RS18160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3348_RS18170	COG3949	Membrane
C3348_RS18175	COG3958	Transketolase
C3348_RS18180	COG3959	Transketolase, thiamine diphosphate binding domain
C3348_RS18185	COG2337	Toxic component of a toxin-antitoxin (TA) module
C3348_RS18205	COG0516	GMP reductase activity
C3348_RS18205	COG0517	IMP dehydrogenase activity
C3348_RS18210	COG0736	holo-[acyl-carrier-protein] synthase activity
C3348_RS18215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3348_RS18220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3348_RS18225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3348_RS18230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3348_RS18235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3348_RS18240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3348_RS18245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3348_RS18275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C3348_RS18275	COG3608	succinylglutamate desuccinylase aspartoacylase
C3348_RS18280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3348_RS18285	COG0698	ribose 5-phosphate isomerase
C3348_RS18295	COG0009	L-threonylcarbamoyladenylate synthase
C3348_RS18305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3348_RS18310	COG2890	protein-(glutamine-N5) methyltransferase activity
C3348_RS18315	COG3872	metal-dependent enzyme
C3348_RS18320	COG0254	rRNA binding
C3348_RS18325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C3348_RS18330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3348_RS18340	COG2208	phosphoserine phosphatase activity
C3348_RS18345	COG0248	Ppx GppA phosphatase
C3348_RS18365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C3348_RS18375	COG3956	TIGRFAM MazG family protein
C3348_RS18380	COG2244	polysaccharide biosynthetic process
C3348_RS18385	COG2002	toxin-antitoxin pair type II binding
C3348_RS18390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3348_RS18395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3348_RS18400	COG0193	aminoacyl-tRNA hydrolase activity
C3348_RS18450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3348_RS18465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3348_RS18470	COG2088	sporulation resulting in formation of a cellular spore
C3348_RS18475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3348_RS18480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3348_RS18490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3348_RS18495	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3348_RS18505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3348_RS18510	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C3348_RS18515	COG1840	ABC-type Fe3 transport system, periplasmic component
C3348_RS18525	COG1840	ABC-type Fe3 transport system, periplasmic component
C3348_RS18535	COG3842	ATPase activity
C3348_RS18540	COG0613	PHP domain protein
C3348_RS18545	COG3454	Phosphonate metabolism
C3348_RS18550	COG4778	phosphonate C-P lyase system protein PhnL
C3348_RS18555	COG4107	phosphonate C-P lyase system protein PhnK
C3348_RS18560	COG3627	carbon phosphorus lyase activity
C3348_RS18580	COG0084	hydrolase, TatD family'
C3348_RS18585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3348_RS18585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3348_RS18590	COG0700	Nucleoside recognition
C3348_RS18600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C3348_RS18605	COG1522	sequence-specific DNA binding
C3348_RS18610	COG0617	tRNA 3'-terminal CCA addition
C3348_RS18615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3348_RS18620	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C3348_RS18625	COG1774	PSP1 C-terminal conserved region
C3348_RS18630	COG0470	DNA polymerase III
C3348_RS18635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3348_RS18640	COG1982	Orn Lys Arg decarboxylase major
C3348_RS18645	COG2155	Conserved Protein
C3348_RS18670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3348_RS18675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3348_RS18685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3348_RS18695	COG3191	aminopeptidase activity
C3348_RS18705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3348_RS18710	COG0037	tRNA processing
C3348_RS18720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3348_RS18735	COG1802	Transcriptional regulator
C3348_RS18740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3348_RS18770	COG0653	protein targeting
C3348_RS18795	COG2271	Major facilitator Superfamily
C3348_RS18800	COG0626	cystathionine gamma-synthase activity
C3348_RS18825	COG0564	pseudouridine synthase activity
C3348_RS18830	COG0789	Transcriptional regulator
C3348_RS18830	COG4978	Transcriptional regulator
C3348_RS18840	COG0577	efflux transmembrane transporter activity
C3348_RS18840	COG1136	(ABC) transporter
C3348_RS18845	COG5002	protein histidine kinase activity
C3348_RS18865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3348_RS18875	COG0284	orotidine-5'-phosphate decarboxylase activity
C3348_RS18895	COG0646	methionine synthase
C3348_RS18895	COG1410	methionine synthase
C3348_RS18905	COG1854	S-ribosylhomocysteine lyase activity
C3348_RS18920	COG1876	peptidase activity
C3348_RS18925	COG0037	tRNA processing
C3348_RS18930	COG1408	metallophosphoesterase
C3348_RS18945	COG1141	Ferredoxin
C3348_RS18950	COG3964	amidohydrolase
C3348_RS18960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3348_RS18970	COG0346	lactoylglutathione lyase activity
C3348_RS18975	COG0534	Mate efflux family protein
C3348_RS19030	COG1674	ftsk spoiiie
C3348_RS19035	COG2946	Replication initiation factor
C3348_RS19085	COG0741	lytic transglycosylase activity
C3348_RS19085	COG0791	NLP P60 protein
C3348_RS19150	COG4978	Transcriptional regulator
C3348_RS19150	COG0789	Transcriptional regulator
C3348_RS19180	COG5504	Zn-dependent protease
C3348_RS19190	COG0519	Catalyzes the synthesis of GMP from XMP
C3348_RS19200	COG1357	PFAM Pentapeptide repeats (8 copies)
C3348_RS19205	COG2824	Alkylphosphonate utilization operon protein PhnA
C3348_RS19220	COG0352	thiamine-phosphate diphosphorylase activity
C3348_RS19225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3348_RS19230	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3348_RS19230	COG0517	IMP dehydrogenase activity
C3348_RS19275	COG0583	DNA-binding transcription factor activity
C3348_RS19280	COG1522	sequence-specific DNA binding
C3348_RS19280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3348_RS19295	COG3964	amidohydrolase
C3348_RS19305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS19310	COG2188	Transcriptional regulator
C3348_RS19315	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3348_RS19320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS19325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C3348_RS19330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3348_RS19335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3348_RS19350	COG1484	DNA-dependent DNA replication
C3348_RS19375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3348_RS19385	COG0305	Participates in initiation and elongation during chromosome replication
C3348_RS19390	COG0359	binds to the 23S rRNA
C3348_RS19395	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C3348_RS19410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3348_RS19415	COG0629	single-stranded DNA binding
C3348_RS19420	COG0360	Binds together with S18 to 16S ribosomal RNA
C3348_RS19425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3348_RS19440	COG0425	Belongs to the sulfur carrier protein TusA family
C3348_RS19455	COG1104	cysteine desulfurase activity
C3348_RS19460	COG1475	DNA binding
C3348_RS19465	COG1192	Involved in chromosome partitioning
C3348_RS19470	COG1475	DNA binding
C3348_RS19475	COG0357	Ribosomal RNA small subunit methyltransferase G
C3348_RS19480	COG0445	tRNA wobble uridine modification
C3348_RS19485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3348_RS19490	COG1847	R3H domain protein
C3348_RS19495	COG0706	membrane insertase activity
C3348_RS19500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3348_RS19505	COG0594	ribonuclease P activity
C3348_RS19510	COG0230	Belongs to the bacterial ribosomal protein bL34 family