locus-tag class description DF008_RS00015 ENOG4108W5M transcriptional regulator DF008_RS00025 ENOG4107RE7 phosphate butyryltransferase DF008_RS00030 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit DF008_RS00035 ENOG41080XS Cobyrinic acid ac-diamide synthase DF008_RS00040 ENOG4105CKU formyltetrahydrofolate synthetase DF008_RS00045 ENOG410908R Methenyltetrahydrofolate cyclohydrolase DF008_RS00050 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DF008_RS00075 ENOG4106HYN CO dehydrogenase acetyl-CoA synthase delta subunit DF008_RS00080 ENOG4105EYX Acetyl-CoA decarbonylase synthase complex subunit gamma DF008_RS00085 ENOG4107VP5 methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase DF008_RS00090 ENOG4105E8X CO dehydrogenase acetyl-CoA synthase complex beta subunit DF008_RS00095 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DF008_RS00110 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DF008_RS00115 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DF008_RS00135 ENOG4108W76 histidinol phosphate phosphatase hisj family DF008_RS00160 ENOG4105E14 MotA TolQ exbB proton channel DF008_RS00165 ENOG4105ER2 Ompa motb domain protein DF008_RS00180 ENOG4105BZU Histidine kinase DF008_RS00185 ENOG4105ENA helicase DF008_RS00190 ENOG4108HW3 (ABC) transporter DF008_RS00195 ENOG4105E5Q amino acid AbC transporter DF008_RS00200 ENOG4105CDA abc transporter atp-binding protein DF008_RS00210 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) DF008_RS00220 ENOG4108DBC nitroreductase DF008_RS00225 ENOG4105BZU Histidine kinase DF008_RS00230 ENOG4105F1A Pyruvate formate-lyase DF008_RS00240 ENOG4105FEU K -dependent Na -Ca exchanger DF008_RS00245 ENOG4105C1J atp-dependent rna helicase DF008_RS00260 ENOG410787A Pts system, glucitol sorbitol-specific DF008_RS00265 ENOG4105DZY Pts system, glucitol sorbitol-specific DF008_RS00270 ENOG4105DZY Pts system, glucitol sorbitol-specific DF008_RS00275 ENOG4105VI0 Pts system, glucitol sorbitol-specific DF008_RS00280 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase DF008_RS00285 ENOG4108J2R molybdopterin oxidoreductase DF008_RS00295 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DF008_RS00300 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DF008_RS00305 ENOG41090VF Stage v sporulation protein ac DF008_RS00310 ENOG4105CZ3 stage V sporulation protein ad DF008_RS00320 ENOG4105ETE Transcriptional regulator (LacI family DF008_RS00335 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DF008_RS00345 ENOG4105BZ4 penicillin-binding protein DF008_RS00355 ENOG4105S1Z Stage IV sporulation protein B DF008_RS00360 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS00365 ENOG4105C5H ABC transporter DF008_RS00380 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DF008_RS00395 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DF008_RS00410 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DF008_RS00415 ENOG4105CDY transcriptional regulatory protein DF008_RS00425 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DF008_RS00440 ENOG4105E39 Enoyl-CoA hydratase DF008_RS00445 ENOG4105CY2 Citrate transporter DF008_RS00460 ENOG4105BZJ Electron transfer flavoprotein DF008_RS00465 ENOG4105C10 Electron transfer flavoprotein DF008_RS00490 ENOG4105BZU Histidine kinase DF008_RS00505 ENOG4105C6F GntR Family Transcriptional Regulator DF008_RS00515 ENOG4105C5Y PTS System DF008_RS00520 ENOG4105CS2 ec 3.2.1.21 DF008_RS00530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS00555 ENOG4108RAC Rubrerythrin DF008_RS00565 ENOG4105MAX Superoxide reductase DF008_RS00570 ENOG4105CBC glutamate synthase DF008_RS00585 ENOG4105C1J atp-dependent rna helicase DF008_RS00590 ENOG4107SDT Homocitrate synthase DF008_RS00595 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DF008_RS00600 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DF008_RS00605 ENOG4108U05 Transcriptional regulator DF008_RS00630 ENOG4105ERH Fumarylacetoacetate hydrolase DF008_RS00635 ENOG4105DC1 bifunctional purine biosynthesis protein purh DF008_RS00645 ENOG4107RA4 Glycosyl transferase (Group 1 DF008_RS00675 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DF008_RS00680 ENOG41083MR nifu domain-containing protein DF008_RS00700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DF008_RS00715 ENOG4108JQ7 (ABC) transporter DF008_RS00720 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS00735 ENOG4105CK1 PTS System DF008_RS00745 ENOG4105F8D glycoside hydrolase family 4 DF008_RS00765 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DF008_RS00770 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DF008_RS00775 ENOG4105E0C molybdate abc transporter DF008_RS00780 ENOG4108IJ6 ABC transporter DF008_RS00785 ENOG4108UW5 maltose o-acetyltransferase DF008_RS00795 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DF008_RS00800 ENOG4105C7J ABC transporter, permease DF008_RS00815 ENOG4105C7J ABC transporter, permease DF008_RS00820 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DF008_RS00835 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DF008_RS00845 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DF008_RS00860 ENOG4105DRR Transcriptional regulator, GntR family DF008_RS00865 ENOG4105CXN decarboxylase DF008_RS00870 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DF008_RS00875 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DF008_RS00880 ENOG4105CYW agmatinase DF008_RS00915 ENOG4105DPH UPF0371 protein DF008_RS00920 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DF008_RS00930 ENOG4105E90 ABC transporter DF008_RS00935 ENOG41076HS cation diffusion facilitator family transporter DF008_RS00965 ENOG4105C3S Mate efflux family protein DF008_RS00970 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DF008_RS00975 ENOG4105DCG PHP domain protein DF008_RS00985 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DF008_RS00990 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DF008_RS00995 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DF008_RS01000 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DF008_RS01010 ENOG4107STF Involved in phosphonate degradation (By similarity) DF008_RS01015 ENOG4108JQ1 Dehydrogenase DF008_RS01025 ENOG4105BZU Histidine kinase DF008_RS01050 ENOG4108Z66 YbaK ebsC protein DF008_RS01055 ENOG4106DSS Tartrate dehydratase subunit alpha DF008_RS01065 ENOG4105C6K Malic enzyme DF008_RS01085 ENOG4105CZE histidine utilization repressor DF008_RS01090 ENOG4105CE4 GlcNAc 6-P deacetylase DF008_RS01095 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DF008_RS01110 ENOG4105BZU Histidine kinase DF008_RS01115 ENOG4105BZU Histidine kinase DF008_RS01120 ENOG41090E6 transcriptional regulator MERR family DF008_RS01130 ENOG4105BZ1 (ABC) transporter DF008_RS01150 ENOG4108VW9 Membrane DF008_RS01160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DF008_RS01165 ENOG4105F38 ABC transporter, permease DF008_RS01170 ENOG4105D38 putrescine abc transporter DF008_RS01175 ENOG4107RUE extracellular solute-binding protein family 1 DF008_RS01185 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DF008_RS01190 ENOG4107R8N Glycosyl transferase, family 2 DF008_RS01205 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DF008_RS01210 ENOG4107X35 defense response to bacterium DF008_RS01235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS01240 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS01250 ENOG4105ENA helicase DF008_RS01260 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DF008_RS01265 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DF008_RS01275 ENOG4105EYH Exonuclease DF008_RS01280 ENOG4108JU6 CBS domain protein DF008_RS01290 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DF008_RS01300 ENOG4108RE9 Phosphodiesterase DF008_RS01305 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DF008_RS01310 ENOG4105CJ1 ABC, transporter DF008_RS01330 ENOG4108UIN ybak prolyl-trna synthetase associated region DF008_RS01335 ENOG4105C1G acyl-Coa dehydrogenase DF008_RS01340 ENOG4105BZJ Electron transfer flavoprotein DF008_RS01345 ENOG4105C10 Electron transfer flavoprotein DF008_RS01350 ENOG4105E39 Enoyl-CoA hydratase DF008_RS01355 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DF008_RS01360 ENOG4105CHU acetyl-coa acetyltransferase DF008_RS01365 ENOG4105C34 Pseudouridine synthase DF008_RS01375 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DF008_RS01400 ENOG4105ETE Transcriptional regulator (LacI family DF008_RS01430 ENOG4107RU2 Histidinol phosphate phosphatase, HisJ family DF008_RS01435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DF008_RS01440 ENOG4105VPS UPF0291 protein DF008_RS01445 ENOG4105DFM M18 family aminopeptidase DF008_RS01450 ENOG4105FDP GntR family transcriptional regulator DF008_RS01470 ENOG4105ETZ PTS System DF008_RS01475 ENOG4105F3R pts system mannose fructose sorbose family iid DF008_RS01480 ENOG4105DUM transcriptional regulator, lysR family DF008_RS01490 ENOG4105CVM Molybdenum cofactor synthesis domain protein DF008_RS01495 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DF008_RS01500 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DF008_RS01505 ENOG4105BZ1 (ABC) transporter DF008_RS01515 ENOG4105CH2 amidohydrolase DF008_RS01530 ENOG4108VAC response regulator DF008_RS01545 ENOG4105C6N Formate acetyltransferase DF008_RS01550 ENOG4105F1A Pyruvate formate-lyase DF008_RS01555 ENOG4108JCI Transcriptional regulator DF008_RS01580 ENOG41086D8 Transcriptional regulator DF008_RS01600 ENOG4105C2M dna polymerase I DF008_RS01605 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DF008_RS01630 ENOG4108UYE Lactoylglutathione lyase DF008_RS01635 ENOG4105K4H Nlp p60 protein DF008_RS01645 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) DF008_RS01650 ENOG4105D6A Electron transport complex DF008_RS01655 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit DF008_RS01660 ENOG4105DZB Electron transport complex DF008_RS01665 ENOG4105DGN Electron transport complex DF008_RS01670 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit DF008_RS01675 ENOG4108Z03 MAF-like protein DF008_RS01680 ENOG4105W5Q DNA repair protein (RadC DF008_RS01685 ENOG4105DFF Rod shape-determining protein mreb DF008_RS01705 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DF008_RS01710 ENOG4107QMS site-determining protein DF008_RS01715 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) DF008_RS01720 ENOG4105CNI cell division protein FtsW DF008_RS01725 ENOG4108Z5K methylglyoxal synthase DF008_RS01745 ENOG4105CNW domain protein DF008_RS01760 ENOG4105C03 ribonuclease DF008_RS01765 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DF008_RS01775 ENOG4105K46 50S ribosomal protein l27 DF008_RS01780 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DF008_RS01790 ENOG4105D6E homoserine dehydrogenase DF008_RS01800 ENOG4105H20 Sporulation integral membrane protein YlbJ DF008_RS01805 ENOG4108KWP DNA-binding transcriptional regulator GlcC DF008_RS01810 ENOG4105QUH Domain of unknown function (DUF2088) DF008_RS01815 ENOG4105BZJ Electron transfer flavoprotein DF008_RS01820 ENOG4105C10 Electron transfer flavoprotein DF008_RS01825 ENOG4105CQB FAD linked oxidase domain protein DF008_RS01830 ENOG4105CDE UPF0348 protein DF008_RS01835 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DF008_RS01845 ENOG41067VY 50S ribosomal protein L32 DF008_RS01850 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DF008_RS01855 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DF008_RS01860 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DF008_RS01865 ENOG4105EA8 2-Nitropropane dioxygenase DF008_RS01870 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DF008_RS01875 ENOG4105CHR reductase DF008_RS01880 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DF008_RS01885 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DF008_RS01890 ENOG4105BZU Histidine kinase DF008_RS01920 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 DF008_RS01925 ENOG4105CD2 stage iii sporulation protein aa DF008_RS01965 ENOG4108ZSR alkaline shock protein DF008_RS01970 ENOG4105M7K Involved in the transcription termination process (By similarity) DF008_RS01975 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DF008_RS01980 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DF008_RS02000 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DF008_RS02005 ENOG4105DX0 Hemolysin A DF008_RS02010 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DF008_RS02020 ENOG4105KY5 gCN5-related N-acetyltransferase DF008_RS02030 ENOG4105S1Z Stage IV sporulation protein B DF008_RS02035 ENOG4107QQR Sporulation DF008_RS02050 ENOG41088M2 Glycosyl transferase family 2 DF008_RS02065 ENOG4108YZ4 nudix hydrolase DF008_RS02075 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DF008_RS02080 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DF008_RS02085 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) DF008_RS02095 ENOG4105HHA aminodeoxychorismate lyase DF008_RS02100 ENOG4108VQJ O-methyltransferase DF008_RS02105 ENOG4105CFP Peptidase U32 DF008_RS02110 ENOG4105CJN penicillin-binding protein DF008_RS02210 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DF008_RS02235 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DF008_RS02245 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DF008_RS02255 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DF008_RS02260 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DF008_RS02265 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DF008_RS02275 ENOG4105K5M 30s ribosomal protein S16 DF008_RS02285 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DF008_RS02290 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DF008_RS02295 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DF008_RS02300 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DF008_RS02320 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DF008_RS02350 ENOG4105CJ1 ABC, transporter DF008_RS02355 ENOG4105WH1 Two component transcriptional regulator luxr family DF008_RS02360 ENOG4105BZU Histidine kinase DF008_RS02365 ENOG4105VFF UPF0102 protein DF008_RS02370 ENOG4105C0P Mg chelatase subunit ChlI DF008_RS02375 ENOG4105C79 DNA protecting protein DprA DF008_RS02380 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DF008_RS02385 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) DF008_RS02390 ENOG4105D1H recombination factor protein RarA DF008_RS02410 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins DF008_RS02415 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DF008_RS02420 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DF008_RS02425 ENOG4105VBH UPF0297 protein DF008_RS02435 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DF008_RS02440 ENOG41068XD UPF0473 protein DF008_RS02445 ENOG4105I3K Ferric uptake regulator, Fur family DF008_RS02455 ENOG4105CN5 Metallo-Beta-Lactamase DF008_RS02465 ENOG4105DZ1 carboxypeptidase DF008_RS02475 ENOG4106AXJ AraC family transcriptional regulator DF008_RS02480 ENOG4108Z4T Peptidase M50 DF008_RS02485 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DF008_RS02490 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DF008_RS02535 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis DF008_RS02540 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DF008_RS02545 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DF008_RS02550 ENOG4105CHV Transcription elongation factor NusA DF008_RS02555 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DF008_RS02565 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DF008_RS02570 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DF008_RS02585 ENOG4105D7V transposase DF008_RS02595 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DF008_RS02600 ENOG4105DTN riboflavin biosynthesis protein ribF DF008_RS02610 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DF008_RS02615 ENOG4105EPR degv family DF008_RS02620 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DF008_RS02625 ENOG4108ZJ4 polysaccharide deacetylase DF008_RS02630 ENOG4105C1V Peptidase, M16 DF008_RS02650 ENOG4105D7V transposase DF008_RS02655 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DF008_RS02665 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) DF008_RS02670 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) DF008_RS02675 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DF008_RS02680 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DF008_RS02685 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) DF008_RS02690 ENOG4105BZU Histidine kinase DF008_RS02700 ENOG4105C3F Signal peptidase i DF008_RS02705 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DF008_RS02715 ENOG4105C9Q fumarate hydratase class II DF008_RS02725 ENOG4105CHM Aminotransferase DF008_RS02735 ENOG4105CGK Exodeoxyribonuclease III DF008_RS02750 ENOG4108QBV Monogalactosyldiacylglycerol synthase DF008_RS02775 ENOG4105DA5 (ABC) transporter DF008_RS02805 ENOG4105VEQ Cold shock protein DF008_RS02815 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DF008_RS02880 ENOG41068JE domain protein DF008_RS02895 ENOG41066EA baseplate J family protein DF008_RS02900 ENOG410906S phage-like element pbsx protein xkdt DF008_RS02950 ENOG4105C0R drug resistance transporter emrb qaca subfamily DF008_RS02960 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DF008_RS02970 ENOG4105E7W lamb ycsf family protein DF008_RS02975 ENOG4105C5A transporter DF008_RS02980 ENOG4105P4J Allophanate hydrolase, subunit 1 DF008_RS02990 ENOG4108IMY Transcriptional regulator DF008_RS02995 ENOG4105DTQ mandelate racemase muconate lactonizing DF008_RS03035 ENOG4108R96 Methyltransferase, YaeB family DF008_RS03040 ENOG4105CH2 amidohydrolase DF008_RS03045 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DF008_RS03060 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DF008_RS03080 ENOG4105C5H ABC transporter DF008_RS03100 ENOG4105CEV competence damage-inducible protein DF008_RS03115 ENOG4108JUB Transcriptional regulator DF008_RS03125 ENOG4105N5T Radical SAM Protein DF008_RS03170 ENOG4105BZU Histidine kinase DF008_RS03175 ENOG4105BZU Histidine kinase DF008_RS03180 ENOG4105BZU Histidine kinase DF008_RS03185 ENOG4108Z5V transcriptional regulator, merr family DF008_RS03200 ENOG4105KT7 mgtC SapB transporter DF008_RS03205 ENOG4108W2Y isochorismatase DF008_RS03230 ENOG4105DVT helicase DF008_RS03235 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DF008_RS03240 ENOG4105D3R alkyl hydroperoxide reductase DF008_RS03255 ENOG41073R8 VanW family DF008_RS03260 ENOG4108JUB Transcriptional regulator DF008_RS03270 ENOG4105VAW lrga family DF008_RS03275 ENOG41067MG lrgb family DF008_RS03280 ENOG4107AYK membrAne DF008_RS03290 ENOG4105K4I Scp-like extracellular DF008_RS03295 ENOG4108ZJ4 polysaccharide deacetylase DF008_RS03300 ENOG4105DDQ anthranilate synthase DF008_RS03305 ENOG4105CRQ synthase (Component I) DF008_RS03310 ENOG4105YAZ 4-amino-4-deoxychorismate lyase DF008_RS03320 ENOG4105EUJ GTP cyclohydrolase i DF008_RS03325 ENOG4105EEI dihydropteroate synthase DF008_RS03330 ENOG4105KRF dihydroneopterin aldolase DF008_RS03335 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DF008_RS03340 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase DF008_RS03345 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DF008_RS03350 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DF008_RS03360 ENOG4105EGD dinuclear metal center protein, YbgI family DF008_RS03365 ENOG4105CS1 NAD(P)H quinone oxidoreductase DF008_RS03385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DF008_RS03400 ENOG4105BZU Histidine kinase DF008_RS03405 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS03425 ENOG4105C72 UPF0176 protein DF008_RS03435 ENOG4105BZ1 (ABC) transporter DF008_RS03440 ENOG4105BZ1 (ABC) transporter DF008_RS03445 ENOG4105KY8 Rubrerythrin DF008_RS03455 ENOG4105BZU Histidine kinase DF008_RS03485 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DF008_RS03520 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DF008_RS03525 ENOG4108UMI ABC transporter, permease DF008_RS03530 ENOG4105D01 (LipO)protein DF008_RS03535 ENOG4105BZU Histidine kinase DF008_RS03540 ENOG4108VX5 3-methyladenine DNA glycosylase DF008_RS03545 ENOG4105WBV Transcriptional regulator DF008_RS03550 ENOG4105II7 pyrroline-5-carboxylate reductase DF008_RS03555 ENOG4105PTM secreted protein DF008_RS03570 ENOG4105CJR Integral membrane protein (MviN DF008_RS03580 ENOG4105D7V transposase DF008_RS03590 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DF008_RS03600 ENOG4108M15 ABC transporter DF008_RS03610 ENOG4105C3S Mate efflux family protein DF008_RS03650 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DF008_RS03655 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DF008_RS03665 ENOG4105BZU Histidine kinase DF008_RS03675 ENOG41090E6 transcriptional regulator MERR family DF008_RS03680 ENOG4105CE1 Ferrous iron transport protein b DF008_RS03700 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DF008_RS03705 ENOG4108ZJ4 polysaccharide deacetylase DF008_RS03715 ENOG4105KY8 Rubrerythrin DF008_RS03725 ENOG4105CD3 dihydroorotase DF008_RS03730 ENOG4107RBB ABC transporter, permease DF008_RS03735 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS03750 ENOG4105CJZ response regulator DF008_RS03765 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DF008_RS03775 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein DF008_RS03780 ENOG4105BZ8 glutamate synthase DF008_RS03785 ENOG4105BZU Histidine kinase DF008_RS03825 ENOG4108UT2 hemolysin iii DF008_RS03835 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DF008_RS03840 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DF008_RS03845 ENOG4105CIH Imidazole acetol-phosphate transaminase DF008_RS03850 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DF008_RS03855 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DF008_RS03860 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DF008_RS03865 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DF008_RS03870 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DF008_RS03875 ENOG4107R7I amino acid DF008_RS03885 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DF008_RS03890 ENOG4105JVQ RNA Polymerase DF008_RS03895 ENOG4108P49 AntiSigma factor DF008_RS03900 ENOG4108P49 AntiSigma factor DF008_RS03905 ENOG4105XRQ Xanthine dehydrogenase accessory factor DF008_RS03920 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DF008_RS03925 ENOG4105C7K acetolactate synthase DF008_RS03930 ENOG4105VTR Integrase DF008_RS03960 ENOG4105WXW Antirepressor DF008_RS03995 ENOG4108UUM single-stranded DNA-binding protein DF008_RS04020 ENOG4105QBX endodeoxyribonuclease RusA DF008_RS04070 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DF008_RS04140 ENOG4105FR7 XkdM protein, phage-like element PBSX DF008_RS04185 ENOG4105X7F DF008_RS04195 ENOG4105MFU Protein of unknown function (DUF2634) DF008_RS04200 ENOG41066EA baseplate J family protein DF008_RS04280 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase DF008_RS04300 ENOG4105WEF catalase DF008_RS04305 ENOG4105C7Z Conserved Protein DF008_RS04315 ENOG4105E5G Alpha beta hydrolase fold DF008_RS04330 ENOG41069ER domain protein DF008_RS04345 ENOG4107U9T Pfam:Ribonuclease_BN DF008_RS04350 ENOG4105BZU Histidine kinase DF008_RS04355 ENOG4105D6E homoserine dehydrogenase DF008_RS04365 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DF008_RS04375 ENOG4105X5K response regulator receiver protein DF008_RS04385 ENOG4105RD7 BadF BadG BcrA BcrD DF008_RS04395 ENOG4105C2J ABC transporter DF008_RS04400 ENOG4105CNN ABC, transporter DF008_RS04405 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DF008_RS04410 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DF008_RS04420 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DF008_RS04425 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DF008_RS04430 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) DF008_RS04440 ENOG4105D7W serine acetyltransferase DF008_RS04445 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein DF008_RS04455 ENOG4106E8G DF008_RS04470 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DF008_RS04475 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DF008_RS04480 ENOG4105VZJ PTS System DF008_RS04500 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DF008_RS04505 ENOG4105CZV ABC transporter DF008_RS04530 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DF008_RS04540 ENOG4108IUW ABC transporter DF008_RS04545 ENOG4108SDH ABC, transporter DF008_RS04550 ENOG4105BZU Histidine kinase DF008_RS04555 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DF008_RS04560 ENOG4105CZV ABC transporter DF008_RS04585 ENOG4105CNW domain protein DF008_RS04600 ENOG4105CPF Cell wall formation (By similarity) DF008_RS04605 ENOG4108UZE carboxy-peptidase DF008_RS04630 ENOG4105CAQ asparagine synthetase DF008_RS04650 ENOG4108N0M stress protein DF008_RS04660 ENOG4108TTB tellurium resistance protein DF008_RS04695 ENOG4105JHY Membrane DF008_RS04700 ENOG4108IGT Dipeptidase DF008_RS04705 ENOG4105DHS permease protein DF008_RS04710 ENOG4105CM4 permease protein DF008_RS04715 ENOG4108IPW abc transporter atp-binding protein DF008_RS04735 ENOG4105D01 (LipO)protein DF008_RS04740 ENOG4105DF9 Lipoate-protein, ligase DF008_RS04745 ENOG4107S6Z Na H antiporter DF008_RS04760 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DF008_RS04765 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DF008_RS04770 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DF008_RS04775 ENOG4105NBK UPF0345 protein DF008_RS04790 ENOG4105D7V transposase DF008_RS04800 ENOG4107QUY Guanine deaminase DF008_RS04815 ENOG4108JCI Transcriptional regulator DF008_RS04820 ENOG4105C6T cysteine synthase DF008_RS04825 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DF008_RS04845 ENOG4105CJ1 ABC, transporter DF008_RS04855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS04875 ENOG4105KVH Transcriptional regulator DF008_RS04880 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DF008_RS04905 ENOG4107Z3H Transcriptional regulator, TetR family DF008_RS04910 ENOG4105DU0 nucleoside hydrolase DF008_RS04940 ENOG4108STX response regulator DF008_RS04945 ENOG4105US7 Histidine kinase DF008_RS04950 ENOG4105K63 Thioredoxin DF008_RS04955 ENOG4105C3M thioredoxin reductase DF008_RS04975 ENOG4108J9M Transporter DF008_RS04990 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DF008_RS04995 ENOG4108R6K riboflavin synthase, subunit alpha DF008_RS05000 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DF008_RS05005 ENOG4105C9U ATP-dependent DNA helicase RecQ DF008_RS05010 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DF008_RS05025 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DF008_RS05030 ENOG4105D41 biosynthesis protein thiH DF008_RS05040 ENOG4105CSX c4-dicarboxylate anaerobic carrier DF008_RS05060 ENOG4108115 UPF0145 protein DF008_RS05065 ENOG4108RIR Molybdenum cofactor biosynthesis protein DF008_RS05075 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DF008_RS05170 ENOG4108Q52 Methyltransferase cognate corrinoid protein DF008_RS05175 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DF008_RS05185 ENOG4105PAD Hydrolase DF008_RS05190 ENOG4107VRI Transcriptional regulator DF008_RS05195 ENOG4107QQ0 gntp family DF008_RS05200 ENOG4105BZU Histidine kinase DF008_RS05205 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS05220 ENOG4108NEV two component transcriptional regulator, LytTR family DF008_RS05245 ENOG4105D6U Sodium Glutamate Symporter DF008_RS05260 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase DF008_RS05265 ENOG4105CIZ coA-substrate-specific enzyme activase DF008_RS05270 ENOG4105JFG SpoIID LytB domain protein DF008_RS05280 ENOG4105PF9 Transcriptional regulator DF008_RS05305 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DF008_RS05330 ENOG4105JAB phenazine biosynthesis protein, phzf family DF008_RS05335 ENOG4105G7B Protein of unknown function (DUF2992) DF008_RS05340 ENOG410696E Membrane DF008_RS05350 ENOG4108YZ4 nudix hydrolase DF008_RS05395 ENOG41063R6 DF008_RS05400 ENOG4106PMH Extracellular solute-binding protein family 3 DF008_RS05405 ENOG4105E5Q amino acid AbC transporter DF008_RS05415 ENOG41080E8 Transcriptional regulator, Spx MgsR family DF008_RS05430 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DF008_RS05445 ENOG4105BZU Histidine kinase DF008_RS05455 ENOG4105CDH Citrulline--aspartate ligase DF008_RS05465 ENOG4107TXC Transcriptional regulator DF008_RS05475 ENOG4108QG2 Membrane DF008_RS05490 ENOG4105EXW epimerase dehydratase DF008_RS05510 ENOG410810Y Sulfite reductase DF008_RS05515 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DF008_RS05535 ENOG4108JYZ YitT family DF008_RS05570 ENOG4105DQ6 Transposase DF008_RS05590 ENOG4105C6X Major Facilitator DF008_RS05595 ENOG4105C6X Major Facilitator DF008_RS05620 ENOG4105CVJ phosphoglycerate mutase DF008_RS05625 ENOG4105CBX hi0933 family DF008_RS05630 ENOG4105CAT Cytidine monophosphate kinase DF008_RS05635 ENOG4105F6E Acyl-transferase DF008_RS05640 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DF008_RS05655 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DF008_RS05660 ENOG4105D1Q UPF0246 protein DF008_RS05675 ENOG4105CVG Homoserine O-transsuccinylase DF008_RS05680 ENOG4105K56 Transcriptional regulator DF008_RS05685 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DF008_RS05690 ENOG4105C08 Histidine kinase DF008_RS05700 ENOG4105D7N magnesium and cobalt transport protein CorA DF008_RS05710 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase DF008_RS05715 ENOG4105D49 3-dehydroquinate synthase DF008_RS05720 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DF008_RS05725 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DF008_RS05730 ENOG4105CQC Prephenate dehydratase DF008_RS05735 ENOG4105E2X shikimate dehydrogenase DF008_RS05745 ENOG4105EVN Prephenate dehydrogenase DF008_RS05750 ENOG4105BZU Histidine kinase DF008_RS05755 ENOG4105BZU Histidine kinase DF008_RS05790 ENOG41086D8 Transcriptional regulator DF008_RS05830 ENOG4105D2X ABC transporter substrate-binding protein DF008_RS05835 ENOG4105DMQ Methyltransferase DF008_RS05840 ENOG4108ZQX ybak prolyl-trna synthetase DF008_RS05870 ENOG4108UK2 deaminase DF008_RS05890 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DF008_RS05910 ENOG4105M3W utilization protein DF008_RS05915 ENOG4105KTW ethanolamine utilization protein DF008_RS05930 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase DF008_RS05935 ENOG4105CPD ethanolamine ammonia-lyase DF008_RS05940 ENOG4107FQ9 ethanolamine ammonia-lyase DF008_RS05945 ENOG4106D67 ethanolamine utilization protein DF008_RS05950 ENOG4105KNY Microcompartments protein DF008_RS05955 ENOG4108EKI Dehydrogenase DF008_RS05960 ENOG4105KNY Microcompartments protein DF008_RS05970 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) DF008_RS05990 ENOG4105ENY Ethanolamine utilization protein eutH DF008_RS05995 ENOG4105NDK ethanolamine utilization protein DF008_RS06010 ENOG4105CH2 amidohydrolase DF008_RS06015 ENOG4105CFC Transporter DF008_RS06020 ENOG4105C87 Aminotransferase class I and II DF008_RS06045 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DF008_RS06050 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DF008_RS06065 ENOG4105MCT stage V sporulation protein S DF008_RS06070 ENOG4108FRU Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DF008_RS06075 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DF008_RS06080 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DF008_RS06085 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DF008_RS06105 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DF008_RS06130 ENOG4105C19 ABC transporter DF008_RS06145 ENOG4108JYZ YitT family DF008_RS06155 ENOG4105DUM transcriptional regulator, lysR family DF008_RS06175 ENOG4108JA5 May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity) DF008_RS06180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DF008_RS06190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS06195 ENOG4105BZU Histidine kinase DF008_RS06200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS06235 ENOG4108UQV Membrane DF008_RS06240 ENOG4108ZQX ybak prolyl-trna synthetase DF008_RS06255 ENOG4107QSE Dipeptidase DF008_RS06260 ENOG4105CXI aluminum resistance protein DF008_RS06265 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DF008_RS06270 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DF008_RS06275 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DF008_RS06280 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DF008_RS06295 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DF008_RS06310 ENOG4105KVH Transcriptional regulator DF008_RS06320 ENOG4105M6F mutator MutT protein DF008_RS06330 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DF008_RS06335 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS06420 ENOG4105EJ9 Membrane DF008_RS06425 ENOG4106R3P AraC family transcriptional regulator DF008_RS06430 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DF008_RS06435 ENOG4108Q5F Tetr family transcriptional regulator DF008_RS06445 ENOG4108Z29 Flavodoxin DF008_RS06450 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DF008_RS06460 ENOG4108IG5 Transcriptional regulator DF008_RS06470 ENOG4105C01 Dihydroxy-acid dehydratase DF008_RS06505 ENOG4108CIP transcriptional regulator DF008_RS06510 ENOG4105C0R drug resistance transporter emrb qaca subfamily DF008_RS06530 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DF008_RS06565 ENOG4105DBV ornithine carbamoyltransferase DF008_RS06570 ENOG4105C8Y Acetylornithine aminotransferase DF008_RS06575 ENOG4105CAS nag kinase DF008_RS06580 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DF008_RS06590 ENOG4105EPI acetyltransferase, (GNAT) family DF008_RS06620 ENOG4105VMP Transcriptional regulator DF008_RS06635 ENOG4106G6Q Transcriptional regulator DF008_RS06645 ENOG4105FE9 pseudouridine synthase DF008_RS06650 ENOG4105DSF transport protein DF008_RS06660 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DF008_RS06665 ENOG4105CFH Aspartokinase DF008_RS06695 ENOG4105CX6 glutaminyL-tRNA synthetase DF008_RS06700 ENOG4105CBD Diacylglycerol kinase DF008_RS06730 ENOG4105VTR Integrase DF008_RS06740 ENOG4105C5H ABC transporter DF008_RS06755 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC DF008_RS06765 ENOG4105C7W Xanthine dehydrogenase DF008_RS06775 ENOG4105C2W permease DF008_RS06790 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DF008_RS06795 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DF008_RS06815 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DF008_RS06830 ENOG4107RCH Diaminopropionate ammonia-lyase DF008_RS06840 ENOG4105C7W Xanthine dehydrogenase DF008_RS06850 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DF008_RS06865 ENOG4108JUB Transcriptional regulator DF008_RS06875 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 DF008_RS06890 ENOG410807C QueT transporter DF008_RS06900 ENOG4105C7W Xanthine dehydrogenase DF008_RS06945 ENOG4105C7N Xanthine uracil vitamin C permease DF008_RS06950 ENOG4107QJQ Mate efflux family protein DF008_RS06960 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DF008_RS06965 ENOG4105E98 transcriptional regulator DeoR family DF008_RS06975 ENOG4105BZU Histidine kinase DF008_RS06980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS07000 ENOG4105CI3 gtp-binding protein typa DF008_RS07005 ENOG4105C3M thioredoxin reductase DF008_RS07010 ENOG4105D98 threonine synthase DF008_RS07045 ENOG4105WCN acetyltransferase DF008_RS07070 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DF008_RS07075 ENOG4105DZP Membrane-associated zinc metalloprotease DF008_RS07080 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DF008_RS07095 ENOG4105BZU Histidine kinase DF008_RS07100 ENOG4105KNE Phosphatidate cytidylyltransferase DF008_RS07105 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DF008_RS07115 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DF008_RS07120 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DF008_RS07125 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DF008_RS07130 ENOG4105CE9 30S ribosomal protein S2 DF008_RS07135 ENOG4105DZ1 carboxypeptidase DF008_RS07150 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) DF008_RS07155 ENOG4105C98 muts2 protein DF008_RS07170 ENOG41073R8 VanW family DF008_RS07190 ENOG4105DER m42 family DF008_RS07200 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DF008_RS07205 ENOG4107QW8 radical SAM domain protein DF008_RS07220 ENOG4108JPW Aminotransferase DF008_RS07255 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DF008_RS07265 ENOG4105E0X reductase DF008_RS07275 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DF008_RS07295 ENOG4105QAX Iron-sulfur DF008_RS07300 ENOG4108J2R molybdopterin oxidoreductase DF008_RS07320 ENOG4105C1J atp-dependent rna helicase DF008_RS07340 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DF008_RS07350 ENOG4107URF beta-phospho-glucomutase DF008_RS07360 ENOG4107RVV histidinol phosphate phosphatase, hisj family DF008_RS07370 ENOG4105JFG SpoIID LytB domain protein DF008_RS07380 ENOG41090A1 ferritin DF008_RS07385 ENOG4105CD5 CoA-binding domain protein DF008_RS07400 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DF008_RS07410 ENOG4105CIH Imidazole acetol-phosphate transaminase DF008_RS07425 ENOG4105MKU Transcriptional regulator DF008_RS07430 ENOG4105C4W S-formylglutathione hydrolase DF008_RS07435 ENOG4105C02 permease DF008_RS07440 ENOG4105C26 Dehydrogenase DF008_RS07455 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DF008_RS07480 ENOG4108V2W Carbonate dehydratase DF008_RS07500 ENOG4105FF2 Type I DHQase DF008_RS07560 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DF008_RS07575 ENOG4107V9H nitrite transporter DF008_RS07580 ENOG410810Y Sulfite reductase DF008_RS07585 ENOG4107SHJ sulfite reductase subunit b DF008_RS07590 ENOG4105D5B Sulfite reductase, subunit A DF008_RS07620 ENOG4107RJ1 sodium solute DF008_RS07625 ENOG4107SCR N-acetylneuraminate lyase DF008_RS07630 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) DF008_RS07650 ENOG4105C5S asparaginyl-tRNA synthetase DF008_RS07660 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DF008_RS07675 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DF008_RS07690 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DF008_RS07695 ENOG4107U9B transcriptional regulator DF008_RS07720 ENOG4105W06 Cupin 2, conserved barrel domain protein DF008_RS07725 ENOG4105DUX Transporter DF008_RS07730 ENOG4105DC7 peptidase M24 DF008_RS07735 ENOG4105DUX Transporter DF008_RS07740 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DF008_RS07760 ENOG4105DM4 PTS System DF008_RS07765 ENOG4105DE4 1-phosphofructokinase DF008_RS07770 ENOG4105EMD TRANSCRIPTIONal DF008_RS07775 ENOG4105M2Z protein tyrosine serine phosphatase DF008_RS07795 ENOG4105BZG amino acid carrier protein DF008_RS07805 ENOG4105CR5 Class II aldolase adducin family protein DF008_RS07810 ENOG4105CPQ Dehydrogenase DF008_RS07815 ENOG4105DT3 PTS system, galactitol-specific IIc component DF008_RS07820 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DF008_RS07825 ENOG4105CTS PTS system mannitol-specific DF008_RS07830 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS07840 ENOG4107U9B transcriptional regulator DF008_RS07845 ENOG4108UMN azlc family DF008_RS07855 ENOG4105BZU Histidine kinase DF008_RS07905 ENOG4105WXW Antirepressor DF008_RS07965 ENOG41067QW Transcriptional regulator DF008_RS07990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DF008_RS08015 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DF008_RS08020 ENOG4105DJV ribulose-phosphate 3-epimerase DF008_RS08025 ENOG4108YZG isomerase DF008_RS08035 ENOG4108HHA Transketolase DF008_RS08045 ENOG4105CPQ Dehydrogenase DF008_RS08050 ENOG4105DT3 PTS system, galactitol-specific IIc component DF008_RS08055 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DF008_RS08065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS08070 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DF008_RS08075 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DF008_RS08080 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase DF008_RS08090 ENOG4105ETD TRANSCRIPTIONal DF008_RS08100 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DF008_RS08105 ENOG4105CDW Resistance protein DF008_RS08115 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase DF008_RS08120 ENOG4105CYC Transferase DF008_RS08135 ENOG4107SG5 Dehydrogenase DF008_RS08140 ENOG4105CYC Transferase DF008_RS08145 ENOG4105D0C transport protein DF008_RS08145 ENOG4105D0C transport protein DF008_RS08150 ENOG4105C5Q Transcriptional regulator DF008_RS08160 ENOG4105DC7 peptidase M24 DF008_RS08185 ENOG4105EZ5 reductase DF008_RS08190 ENOG41080XV Thioredoxin DF008_RS08210 ENOG410667J hydrolase DF008_RS08225 ENOG4105D7T ABC transporter DF008_RS08235 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DF008_RS08275 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DF008_RS08285 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DF008_RS08305 ENOG4106F5Q Membrane DF008_RS08310 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DF008_RS08315 ENOG4108VW9 Membrane DF008_RS08320 ENOG4105CKM Branched-chain carboxylic acid kinase DF008_RS08345 ENOG4105BZU Histidine kinase DF008_RS08350 ENOG4105BZU Histidine kinase DF008_RS08380 ENOG4105NA0 Transcriptional regulator DF008_RS08400 ENOG4105NA0 Transcriptional regulator DF008_RS08410 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DF008_RS08415 ENOG4108JQC penicillin-binding protein 1A DF008_RS08420 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DF008_RS08440 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) DF008_RS08455 ENOG4105WEF catalase DF008_RS08460 ENOG4105K4H Nlp p60 protein DF008_RS08465 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DF008_RS08470 ENOG4105C9U ATP-dependent DNA helicase RecQ DF008_RS08500 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DF008_RS08505 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DF008_RS08530 ENOG4105EMD TRANSCRIPTIONal DF008_RS08535 ENOG4105DZY Pts system, glucitol sorbitol-specific DF008_RS08540 ENOG410787A Pts system, glucitol sorbitol-specific DF008_RS08560 ENOG4105BZG amino acid carrier protein DF008_RS08565 ENOG4108ITV Inner membrane protein yqcE DF008_RS08570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DF008_RS08575 ENOG4107RE7 phosphate butyryltransferase DF008_RS08580 ENOG4105CKM Branched-chain carboxylic acid kinase DF008_RS08595 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DF008_RS08605 ENOG4107HP6 Transcriptional regulator DF008_RS08615 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DF008_RS08620 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DF008_RS08630 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) DF008_RS08640 ENOG4105CJW magnesium transporter DF008_RS08645 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DF008_RS08650 ENOG4105KG3 cytidine deaminase DF008_RS08655 ENOG41080IJ Diacylglycerol kinase DF008_RS08660 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DF008_RS08665 ENOG4105C9A Phoh family DF008_RS08685 ENOG4105KAV tspo and mbr like protein DF008_RS08690 ENOG4105KTH gatB Yqey DF008_RS08695 ENOG4105VCC 30S ribosomal protein S21 DF008_RS08700 ENOG4107YU2 histidine triad (hIT) protein DF008_RS08705 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DF008_RS08710 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DF008_RS08715 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DF008_RS08750 ENOG4105G9B Transcriptional regulator DF008_RS08755 ENOG41080V3 Major Facilitator superfamily DF008_RS08760 ENOG4105DKQ ROK family DF008_RS08770 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DF008_RS08775 ENOG4105CFG Acts as a chaperone (By similarity) DF008_RS08780 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DF008_RS08785 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DF008_RS08790 ENOG4105CSA Coproporphyrinogen iii oxidase DF008_RS08795 ENOG4107R7I amino acid DF008_RS08800 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DF008_RS08805 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DF008_RS08820 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DF008_RS08835 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DF008_RS08845 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DF008_RS08865 ENOG4105CUZ uba thif-type nad fad binding protein DF008_RS08875 ENOG41069ER domain protein DF008_RS08880 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DF008_RS08895 ENOG4105C87 Aminotransferase class I and II DF008_RS08900 ENOG4105DC7 peptidase M24 DF008_RS08905 ENOG410863U PTS System DF008_RS08910 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DF008_RS08915 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DF008_RS08920 ENOG4105EMD TRANSCRIPTIONal DF008_RS08925 ENOG4107QSE Dipeptidase DF008_RS08930 ENOG4105DG6 mannose-6-phosphate isomerase DF008_RS08935 ENOG4105BZU Histidine kinase DF008_RS08940 ENOG4105EM7 Selenocysteine-specific translation elongation factor DF008_RS08955 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein DF008_RS08960 ENOG4105DZ1 carboxypeptidase DF008_RS08970 ENOG4105CH7 arginosuccinase DF008_RS08980 ENOG4105CIH Imidazole acetol-phosphate transaminase DF008_RS08985 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DF008_RS08990 ENOG4108VXD carboxy-peptidase DF008_RS08995 ENOG4105R8C Transcriptional regulator DF008_RS09010 ENOG41063TF transcriptional regulator (AraC DF008_RS09015 ENOG4105F8D glycoside hydrolase family 4 DF008_RS09020 ENOG4105CI1 PTS System DF008_RS09025 ENOG4105CID antiterminator DF008_RS09030 ENOG4105C5Y PTS System DF008_RS09035 ENOG4105KME endoribonuclease L-psp DF008_RS09040 ENOG4105C7B Threonine dehydratase DF008_RS09045 ENOG4105CEB Aspartate aminotransferase DF008_RS09050 ENOG4105HDK L-asparaginase DF008_RS09075 ENOG4105VTR Integrase DF008_RS09090 ENOG4105C8T Leucyl-tRNA synthetase DF008_RS09100 ENOG4108WF2 Metal Dependent Phosphohydrolase DF008_RS09105 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DF008_RS09110 ENOG41084X6 Modulates RecA activity (By similarity) DF008_RS09115 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DF008_RS09120 ENOG4108RZE Tetr family transcriptional regulator DF008_RS09145 ENOG4105C5R Aminotransferase DF008_RS09155 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS09160 ENOG4105BZU Histidine kinase DF008_RS09165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS09170 ENOG4105CGH 5'-nucleotidase DF008_RS09180 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DF008_RS09185 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DF008_RS09200 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DF008_RS09215 ENOG4108K2F hydrolase Family 5 DF008_RS09225 ENOG4105DRS transport system, permease DF008_RS09245 ENOG4108SU4 UPF0309 protein DF008_RS09250 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC DF008_RS09270 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DF008_RS09275 ENOG4106H78 methyltransferase DF008_RS09285 ENOG4105DP4 dak2 domain fusion protein ylov DF008_RS09290 ENOG4108ZAA Alkaline-shock protein DF008_RS09295 ENOG4105VB9 50S ribosomal protein l28 DF008_RS09310 ENOG4107TXC Transcriptional regulator DF008_RS09315 ENOG4105EMD TRANSCRIPTIONal DF008_RS09320 ENOG4105EMD TRANSCRIPTIONal DF008_RS09325 ENOG4108YRF PTS System DF008_RS09330 ENOG4105DM4 PTS System DF008_RS09335 ENOG4105C8I hydrolase, family 38 DF008_RS09360 ENOG4105FJ0 thiamine DF008_RS09365 ENOG4105DJV ribulose-phosphate 3-epimerase DF008_RS09370 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DF008_RS09375 ENOG4105CHR reductase DF008_RS09380 ENOG4105D9P serine threonine protein kinase DF008_RS09390 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DF008_RS09395 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DF008_RS09410 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DF008_RS09415 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DF008_RS09420 ENOG4105C25 Primosomal protein n' DF008_RS09425 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DF008_RS09430 ENOG41067UH Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) DF008_RS09435 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DF008_RS09440 ENOG4105DSJ YicC domain protein DF008_RS09445 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DF008_RS09455 ENOG4105F23 Fibronectin-binding protein DF008_RS09460 ENOG4105C5H ABC transporter DF008_RS09465 ENOG4105C2W permease DF008_RS09470 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DF008_RS09475 ENOG4105C34 Pseudouridine synthase DF008_RS09480 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DF008_RS09485 ENOG4108ZJ4 polysaccharide deacetylase DF008_RS09500 ENOG4105DY9 regulatoR DF008_RS09505 ENOG4108HRK Histidine kinase DF008_RS09515 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DF008_RS09520 ENOG4105E5D amino acid DF008_RS09525 ENOG4105DC7 peptidase M24 DF008_RS09530 ENOG4105EPR degv family DF008_RS09535 ENOG41062JF Transcriptional regulator DF008_RS09545 ENOG4108JYZ YitT family DF008_RS09550 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DF008_RS09560 ENOG4105DBK s4 domain protein DF008_RS09570 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DF008_RS09575 ENOG4105DFA alanine racemase domain protein DF008_RS09595 ENOG4105VUC UPF0237 protein DF008_RS09605 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DF008_RS09610 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DF008_RS09615 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DF008_RS09620 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DF008_RS09630 ENOG41065D1 DF008_RS09635 ENOG4105S2F DF008_RS09640 ENOG4105S2F DF008_RS09645 ENOG4105BZU Histidine kinase DF008_RS09650 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS09655 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DF008_RS09660 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DF008_RS09665 ENOG4105WR5 sporulation protein, YlmC YmxH family DF008_RS09670 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DF008_RS09675 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DF008_RS09680 ENOG4105FFI sigma-e processing peptidase spoiiga DF008_RS09690 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DF008_RS09695 ENOG4105K67 small basic protein DF008_RS09710 ENOG4105JUY domain protein, FtsQ-type DF008_RS09715 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DF008_RS09720 ENOG4105CNI cell division protein FtsW DF008_RS09725 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DF008_RS09730 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DF008_RS09735 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DF008_RS09740 ENOG4105CJN penicillin-binding protein DF008_RS09750 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DF008_RS09755 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DF008_RS09770 ENOG4105C3G gtp-binding protein DF008_RS09775 ENOG4105BZU Histidine kinase DF008_RS09780 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DF008_RS09795 ENOG4105CID antiterminator DF008_RS09800 ENOG4107SUZ Sodium/hydrogen exchanger family DF008_RS09805 ENOG4108JQ7 (ABC) transporter DF008_RS09810 ENOG4105C3U ABC transporter DF008_RS09825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DF008_RS09830 ENOG4105CMU LysR family (Transcriptional regulator DF008_RS09835 ENOG4105CHU acetyl-coa acetyltransferase DF008_RS09840 ENOG4107QP7 CoA-transferase subunit A DF008_RS09850 ENOG4105DTD Dehydrogenase DF008_RS09855 ENOG4105CY2 Citrate transporter DF008_RS09860 ENOG4105K4I Scp-like extracellular DF008_RS09875 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) DF008_RS09910 ENOG4105CBX hi0933 family DF008_RS09915 ENOG410841Q phosphoesterase PA-phosphatase related protein DF008_RS09920 ENOG4108UGV hypoxanthine phosphoribosyltransferase DF008_RS09925 ENOG4107QZB decarboxylase DF008_RS09940 ENOG4105CU9 asparagine synthetase A DF008_RS09945 ENOG4105C87 Aminotransferase class I and II DF008_RS09960 ENOG41074DU domain protein DF008_RS09985 ENOG4105C7N Xanthine uracil vitamin C permease DF008_RS09990 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DF008_RS10000 ENOG4105EMV Major Facilitator DF008_RS10020 ENOG4107RSM transcriptional regulator DF008_RS10030 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein DF008_RS10035 ENOG4105CMR udp-glucose 4-epimerase DF008_RS10040 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DF008_RS10065 ENOG4105KFN sortase, SrtB family DF008_RS10095 ENOG4108SWU Histidine kinase DF008_RS10100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DF008_RS10120 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DF008_RS10140 ENOG4105VPX protein, conserved in bacteria DF008_RS10155 ENOG4105C87 Aminotransferase class I and II DF008_RS10160 ENOG4105DFD Na H antiporter DF008_RS10170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS10175 ENOG4107RSM transcriptional regulator DF008_RS10180 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DF008_RS10190 ENOG4105C9M aspartyl-trna synthetase DF008_RS10195 ENOG4105CUT histidyl-tRNA synthetase DF008_RS10200 ENOG4105D4P Coproporphyrinogen iii oxidase DF008_RS10205 ENOG4107VMB Beta-lactamase domain protein DF008_RS10210 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DF008_RS10215 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DF008_RS10220 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DF008_RS10225 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DF008_RS10235 ENOG4108Z0R Transferase DF008_RS10270 ENOG4105BZU Histidine kinase DF008_RS10275 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DF008_RS10280 ENOG4105KRI phosphocarrier protein (HPr DF008_RS10300 ENOG4105BZU Histidine kinase DF008_RS10305 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS10310 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DF008_RS10320 ENOG4108HCJ Hydrolase DF008_RS10325 ENOG4108KGH TRANSCRIPTIONal DF008_RS10330 ENOG4108KGH TRANSCRIPTIONal DF008_RS10335 ENOG4105F32 YngK protein DF008_RS10340 ENOG4108FKR NLP P60 protein DF008_RS10350 ENOG4105CPK Glycosyl transferase (Group 1 DF008_RS10355 ENOG4105C6Y Udp-glucose 6-dehydrogenase DF008_RS10375 ENOG4107VDP teichoic acid biosynthesis DF008_RS10380 ENOG4105K64 Glycosyl transferase, family 2 DF008_RS10405 ENOG4105CJR Integral membrane protein (MviN DF008_RS10410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS10420 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS10430 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS10440 ENOG4105WH5 Teichoic acid glycosylation protein DF008_RS10460 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DF008_RS10495 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS10510 ENOG4105VIE preprotein translocase, subunit YajC DF008_RS10515 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DF008_RS10525 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DF008_RS10530 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DF008_RS10535 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DF008_RS10540 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DF008_RS10565 ENOG4105C6Z Gluconate DF008_RS10570 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DF008_RS10590 ENOG4105BZ1 (ABC) transporter DF008_RS10610 ENOG4108P2H Inner membrane protein YjiG DF008_RS10615 ENOG41074DU domain protein DF008_RS10620 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DF008_RS10650 ENOG4105CHM Aminotransferase DF008_RS10655 ENOG4108TVT permease DF008_RS10660 ENOG4106E8G DF008_RS10670 ENOG4105PGM cation diffusion facilitator family transporter DF008_RS10685 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DF008_RS10690 ENOG4105CFC Transporter DF008_RS10695 ENOG4105CH2 amidohydrolase DF008_RS10715 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DF008_RS10740 ENOG4108RAC Rubrerythrin DF008_RS10760 ENOG4107STF Involved in phosphonate degradation (By similarity) DF008_RS10765 ENOG410804X Transcriptional regulator DF008_RS10770 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) DF008_RS10775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DF008_RS10780 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) DF008_RS10790 ENOG4105EE0 oxidoreductase DF008_RS10800 ENOG4107YBY Hydrolase DF008_RS10805 ENOG4105C37 (CBS) domain DF008_RS10830 ENOG4108JUB Transcriptional regulator DF008_RS10835 ENOG4107S9D Alpha beta hydrolase DF008_RS10845 ENOG4105CMS peptidase U62, modulator of DNA gyrase DF008_RS10850 ENOG4105D1U peptidase U62 modulator of DNA gyrase DF008_RS10865 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) DF008_RS10875 ENOG4105CTX dehydratase DF008_RS10880 ENOG4105BZU Histidine kinase DF008_RS10890 ENOG4105E0A ABC, transporter DF008_RS10895 ENOG4105EHG Permease protein DF008_RS10900 ENOG4105DQ5 transport system permease protein DF008_RS10915 ENOG4105VCP PTS System DF008_RS10920 ENOG410901P UPF0249 protein DF008_RS10925 ENOG4105F8D glycoside hydrolase family 4 DF008_RS10930 ENOG4105CK1 PTS System DF008_RS10940 ENOG4105FDP GntR family transcriptional regulator DF008_RS10945 ENOG4105CG3 alpha amylase, catalytic region DF008_RS10950 ENOG4105C5Y PTS System DF008_RS10960 ENOG4107414 GntR family transcriptional regulator DF008_RS10965 ENOG4107RCV ABC transporter, permease DF008_RS10970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DF008_RS10980 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DF008_RS10985 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) DF008_RS10990 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) DF008_RS11005 ENOG4105QD4 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DF008_RS11040 ENOG4105BZU Histidine kinase DF008_RS11045 ENOG4108EKI Dehydrogenase DF008_RS11055 ENOG4108S0H Dipicolinic acid synthetase, b subunit DF008_RS11065 ENOG4107F3J Amp-dependent synthetase and ligase DF008_RS11070 ENOG4105CHU acetyl-coa acetyltransferase DF008_RS11075 ENOG41080Y5 BioY family DF008_RS11090 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) DF008_RS11105 ENOG4105DTT CRISPR-associated helicase, cas3 DF008_RS11145 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DF008_RS11170 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DF008_RS11185 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DF008_RS11190 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DF008_RS11200 ENOG4105E0A ABC, transporter DF008_RS11205 ENOG4105EHG Permease protein DF008_RS11240 ENOG4105C19 ABC transporter DF008_RS11255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DF008_RS11260 ENOG4105ERH Fumarylacetoacetate hydrolase DF008_RS11275 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) DF008_RS11285 ENOG4105C0A alcohol dehydrogenase DF008_RS11290 ENOG4105S7A ErfK ybiS ycfS ynhG family protein DF008_RS11300 ENOG4107QN2 dihydrolipoyl dehydrogenase DF008_RS11305 ENOG4107QIV Cytochrome c biogenesis protein DF008_RS11310 ENOG4107Z6X Transcriptional regulator DF008_RS11315 ENOG4105C8I hydrolase, family 38 DF008_RS11320 ENOG4105DM4 PTS System DF008_RS11325 ENOG4108YRF PTS System DF008_RS11330 ENOG4105DM4 PTS System DF008_RS11375 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DF008_RS11385 ENOG4105C5Y PTS System DF008_RS11390 ENOG4105C2X Arabinose 5-phosphate isomerase DF008_RS11395 ENOG4105C87 Aminotransferase class I and II DF008_RS11400 ENOG4105CI1 PTS System DF008_RS11405 ENOG4105CID antiterminator DF008_RS11410 ENOG4105C9B Cysteine desulfurase DF008_RS11415 ENOG4105K63 Thioredoxin DF008_RS11425 ENOG4105JAB phenazine biosynthesis protein, phzf family DF008_RS11430 ENOG4105DUX Transporter DF008_RS11445 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DF008_RS11455 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) DF008_RS11470 ENOG4106KNT transcriptional regulator DF008_RS11475 ENOG4105RD7 BadF BadG BcrA BcrD DF008_RS11480 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DF008_RS11490 ENOG4105CK1 PTS System DF008_RS11505 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DF008_RS11510 ENOG4105EWM Histidine kinase DF008_RS11525 ENOG4105C19 ABC transporter DF008_RS11535 ENOG4105C5Y PTS System DF008_RS11545 ENOG4105F8D glycoside hydrolase family 4 DF008_RS11550 ENOG4105CI1 PTS System DF008_RS11565 ENOG4105C93 Xylose Isomerase DF008_RS11570 ENOG4105CMG Carbohydrate kinase DF008_RS11585 ENOG4108EQA pts system DF008_RS11590 ENOG4105F3R pts system mannose fructose sorbose family iid DF008_RS11595 ENOG4105ETZ PTS System DF008_RS11620 ENOG4107SCJ type I restriction enzyme EcoKI subunit R DF008_RS11645 ENOG4105CVR type I restriction-modification system DF008_RS11650 ENOG4105D2N Aldolase DF008_RS11655 ENOG4105DM4 PTS System DF008_RS11670 ENOG4105CS2 ec 3.2.1.21 DF008_RS11680 ENOG4105CK1 PTS System DF008_RS11690 ENOG4105CTS PTS system mannitol-specific DF008_RS11695 ENOG4105BZW Glycerate kinase DF008_RS11700 ENOG4105C8I hydrolase, family 38 DF008_RS11705 ENOG4105DM4 PTS System DF008_RS11710 ENOG4105HX0 Transcriptional regulator DF008_RS11715 ENOG410901P UPF0249 protein DF008_RS11720 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane DF008_RS11725 ENOG4108X79 transcriptional regulator DF008_RS11730 ENOG4105CG3 alpha amylase, catalytic region DF008_RS11740 ENOG4108Z86 Glutamine amidotransferase DF008_RS11755 ENOG4105CS2 ec 3.2.1.21 DF008_RS11760 ENOG4105CS2 ec 3.2.1.21 DF008_RS11765 ENOG4105C5Y PTS System DF008_RS11770 ENOG4105CID antiterminator DF008_RS11780 ENOG4105CSX c4-dicarboxylate anaerobic carrier DF008_RS11785 ENOG4105CI1 PTS System DF008_RS11790 ENOG4107QSE Dipeptidase DF008_RS11810 ENOG4105D7V transposase DF008_RS11825 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DF008_RS11835 ENOG4107AYK membrAne DF008_RS11840 ENOG4105DJV ribulose-phosphate 3-epimerase DF008_RS11845 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 DF008_RS11855 ENOG4105CH2 amidohydrolase DF008_RS11860 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DF008_RS11870 ENOG4105CS2 ec 3.2.1.21 DF008_RS11875 ENOG4105C5Y PTS System DF008_RS11890 ENOG41087PP glycosyltransferase MGT family DF008_RS11895 ENOG41067QW Transcriptional regulator DF008_RS11910 ENOG41082BM Transcriptional regulator, arsr family DF008_RS11920 ENOG4105CS2 ec 3.2.1.21 DF008_RS11925 ENOG4105C5Y PTS System DF008_RS11930 ENOG4105CID antiterminator DF008_RS11940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS11945 ENOG4105BZ1 (ABC) transporter DF008_RS11985 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) DF008_RS11990 ENOG4105C5Y PTS System DF008_RS11995 ENOG4107URF beta-phospho-glucomutase DF008_RS12005 ENOG4105CS2 ec 3.2.1.21 DF008_RS12010 ENOG4108KB1 transcriptional regulator, arac family DF008_RS12015 ENOG4105DM4 PTS System DF008_RS12020 ENOG4105ETD TRANSCRIPTIONal DF008_RS12025 ENOG4105DM4 PTS System DF008_RS12030 ENOG4105D2N Aldolase DF008_RS12050 ENOG4108V4B ThiJ pfpI DF008_RS12065 ENOG4105KFN sortase, SrtB family DF008_RS12090 ENOG4107Y5K Resolvase DF008_RS12130 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DF008_RS12155 ENOG4105DA5 (ABC) transporter DF008_RS12165 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DF008_RS12180 ENOG4108V1U phospholipid-binding protein DF008_RS12200 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DF008_RS12205 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DF008_RS12210 ENOG4105CP7 Triose-phosphate isomerase DF008_RS12215 ENOG4105BZA Phosphoglycerate kinase DF008_RS12230 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DF008_RS12235 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding DF008_RS12245 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DF008_RS12255 ENOG4107UUR Chlorohydrolase aminohydrolase DF008_RS12270 ENOG4107RCH Diaminopropionate ammonia-lyase DF008_RS12280 ENOG4108JUB Transcriptional regulator DF008_RS12285 ENOG4105KME endoribonuclease L-psp DF008_RS12300 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DF008_RS12305 ENOG4105VUF Transcriptional regulator DF008_RS12315 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DF008_RS12320 ENOG4105C19 ABC transporter DF008_RS12350 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DF008_RS12360 ENOG4107SWG transcriptional regulator MERR family DF008_RS12385 ENOG4105F3H Histidine kinase DF008_RS12390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS12395 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DF008_RS12400 ENOG4108RCM Nitroreductase DF008_RS12435 ENOG4108D32 Methyltransferase DF008_RS12455 ENOG4108HQR Glycine betaine DF008_RS12460 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DF008_RS12470 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DF008_RS12475 ENOG4105DXX methyltransferase DF008_RS12490 ENOG4105EJQ L-serine dehydratase DF008_RS12495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DF008_RS12500 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DF008_RS12505 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DF008_RS12510 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DF008_RS12515 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) DF008_RS12525 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DF008_RS12535 ENOG4108UGV hypoxanthine phosphoribosyltransferase DF008_RS12540 ENOG4105CEM UPF0597 protein DF008_RS12545 ENOG4108JUB Transcriptional regulator DF008_RS12550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DF008_RS12565 ENOG4105CTU Proline racemase DF008_RS12575 ENOG41088D5 d-proline reductase DF008_RS12580 ENOG41088D5 d-proline reductase DF008_RS12595 ENOG41088D5 d-proline reductase DF008_RS12610 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) DF008_RS12645 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DF008_RS12655 ENOG4105DY9 regulatoR DF008_RS12660 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DF008_RS12665 ENOG4107VMI polysaccharide deacetylase DF008_RS12680 ENOG4108UTW Plays a role in the regulation of phosphate uptake DF008_RS12685 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DF008_RS12690 ENOG4105E2Z phosphate ABC transporter (Permease DF008_RS12695 ENOG4105C8U phosphate abc transporter DF008_RS12710 ENOG4105BZU Histidine kinase DF008_RS12715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS12720 ENOG4105CVA phosphate DF008_RS12725 ENOG4105DPN Oligoendopeptidase f DF008_RS12730 ENOG4105KT7 mgtC SapB transporter DF008_RS12755 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DF008_RS12760 ENOG4105F3R pts system mannose fructose sorbose family iid DF008_RS12765 ENOG4105ETZ PTS System DF008_RS12770 ENOG4108EQA pts system DF008_RS12775 ENOG4108EQA pts system DF008_RS12785 ENOG4105II7 pyrroline-5-carboxylate reductase DF008_RS12790 ENOG4105C6N Formate acetyltransferase DF008_RS12795 ENOG4105F1A Pyruvate formate-lyase DF008_RS12800 ENOG4105C0H protease DF008_RS12805 ENOG4107QYV phosphohexose isomerase DF008_RS12810 ENOG4105EAM Na Pi-cotransporter DF008_RS12815 ENOG4105DZ0 fad dependent oxidoreductase DF008_RS12830 ENOG41060AI SEC-C motif DF008_RS12855 ENOG4105D7Q type ii secretion system DF008_RS12860 ENOG4107QHF type ii secretion system protein e DF008_RS12875 ENOG4105C0R drug resistance transporter emrb qaca subfamily DF008_RS12880 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DF008_RS12885 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DF008_RS12895 ENOG4105CAH Chromate DF008_RS12900 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DF008_RS12905 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DF008_RS12910 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DF008_RS12925 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DF008_RS12945 ENOG4105BZ8 glutamate synthase DF008_RS12950 ENOG4107QHI -hydrogenase DF008_RS12955 ENOG4108RC0 Electron transport protein DF008_RS12965 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DF008_RS13015 ENOG4107TVC Glycosyl transferase, family 2 DF008_RS13025 ENOG4108DMH HTH_ARAC DF008_RS13030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DF008_RS13040 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase DF008_RS13045 ENOG4105KVH Transcriptional regulator DF008_RS13050 ENOG4108Z0Z intracellular protease Pfpi family DF008_RS13060 ENOG4105C5H ABC transporter DF008_RS13065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DF008_RS13085 ENOG4108IUW ABC transporter DF008_RS13090 ENOG4105BZU Histidine kinase DF008_RS13125 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DF008_RS13135 ENOG4105CTQ phosphohexokinase DF008_RS13140 ENOG4105C0B DNA polymerase III (alpha subunit) DF008_RS13145 ENOG4105CIE May be required for sporulation (By similarity) DF008_RS13150 ENOG41062IR nudix hydrolase DF008_RS13160 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DF008_RS13170 ENOG4105D4A Cell wall formation (By similarity) DF008_RS13175 ENOG4105TMB Formate nitrite transporter DF008_RS13180 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DF008_RS13185 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit DF008_RS13190 ENOG4107QIZ NADH dehydrogenase DF008_RS13195 ENOG4107QHI -hydrogenase DF008_RS13210 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DF008_RS13220 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DF008_RS13230 ENOG4108IJG ABC transporter substrate-binding protein DF008_RS13240 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DF008_RS13265 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DF008_RS13270 ENOG4105D52 delta-aminolevulinic acid dehydratase DF008_RS13280 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DF008_RS13285 ENOG4107PPM cobalt chelatase DF008_RS13295 ENOG4105E4R Precorrin-3B C17-methyltransferase DF008_RS13300 ENOG4108P62 biosynthesis protein (CbiG) DF008_RS13305 ENOG4105CIA precorrin-4 C(11)-methyltransferase DF008_RS13310 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase DF008_RS13315 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase DF008_RS13320 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) DF008_RS13325 ENOG41081F0 Precorrin-8x methylmutase DF008_RS13330 ENOG4105JZC GHMP kinase DF008_RS13335 ENOG4105CIH Imidazole acetol-phosphate transaminase DF008_RS13345 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DF008_RS13350 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DF008_RS13355 ENOG4105CVJ phosphoglycerate mutase DF008_RS13360 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) DF008_RS13365 ENOG4108YZT Adenosylcobinamide kinase DF008_RS13370 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DF008_RS13390 ENOG4105C87 Aminotransferase class I and II DF008_RS13400 ENOG4105CK1 PTS System DF008_RS13405 ENOG4105VZJ PTS System DF008_RS13410 ENOG4105VCP PTS System DF008_RS13415 ENOG4105CN9 Peptidase m42 family protein DF008_RS13420 ENOG4105CID antiterminator DF008_RS13425 ENOG4105D2N Aldolase DF008_RS13430 ENOG4105E70 isomerase DF008_RS13435 ENOG4105EP9 oxidoreductase DF008_RS13445 ENOG4105FDP GntR family transcriptional regulator DF008_RS13450 ENOG4105CE4 GlcNAc 6-P deacetylase DF008_RS13470 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DF008_RS13480 ENOG4108K88 Membrane DF008_RS13485 ENOG4108IUS Transketolase DF008_RS13490 ENOG4108HHA Transketolase DF008_RS13495 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DF008_RS13505 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DF008_RS13515 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DF008_RS13520 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DF008_RS13525 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DF008_RS13530 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DF008_RS13535 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DF008_RS13540 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DF008_RS13545 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DF008_RS13550 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) DF008_RS13555 ENOG41085E0 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DF008_RS13580 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family DF008_RS13585 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DF008_RS13590 ENOG4108YZG isomerase DF008_RS13600 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DF008_RS13610 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DF008_RS13615 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DF008_RS13620 ENOG4105CBJ Metal-dependent enzyme DF008_RS13625 ENOG41082DI 50s ribosomal protein l31 DF008_RS13630 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DF008_RS13635 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DF008_RS13650 ENOG4105C9X ppx gppa phosphatase DF008_RS13670 ENOG41082I2 s4 domain protein DF008_RS13675 ENOG4105K70 DNA-binding protein DF008_RS13680 ENOG4108IY2 MazG family DF008_RS13690 ENOG4108M14 stage v sporulation protein t DF008_RS13695 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DF008_RS13700 ENOG4108JA2 transcriptioN-repair coupling factor DF008_RS13705 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DF008_RS13715 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) DF008_RS13720 ENOG4105CZX twitching motility protein DF008_RS13755 ENOG4107QHF type ii secretion system protein e DF008_RS13770 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DF008_RS13775 ENOG4105K4W Could be involved in septation (By similarity) DF008_RS13780 ENOG4105DFT pur operon repressor DF008_RS13785 ENOG4105DFU Cell wall formation (By similarity) DF008_RS13795 ENOG41076HS cation diffusion facilitator family transporter DF008_RS13800 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DF008_RS13810 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DF008_RS13815 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DF008_RS13825 ENOG4107RCV ABC transporter, permease DF008_RS13840 ENOG4107RCV ABC transporter, permease DF008_RS13850 ENOG4105DB7 PHP domain protein DF008_RS13855 ENOG4105FD8 phosphonate metabolism protein PhnM DF008_RS13860 ENOG4105HRV phosphonate c-p lyase system protein phnl DF008_RS13865 ENOG4105ENV phosphonate C-P lyase system protein PhnK DF008_RS13870 ENOG4105FT8 Phosphonate metabolism DF008_RS13890 ENOG4105F8V Hydrolase, tatD family DF008_RS13895 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DF008_RS13910 ENOG4105DAP Nicotinate phosphoribosyltransferase DF008_RS13925 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DF008_RS13930 ENOG41060K3 Methyltransferase DF008_RS13935 ENOG4105MA4 psp1 domain protein DF008_RS13940 ENOG4105FA2 dna polymerase iii DF008_RS13945 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DF008_RS13950 ENOG4105CXN decarboxylase DF008_RS13955 ENOG4105WG9 Conserved Protein DF008_RS13980 ENOG4105CRK lysyL-tRNA synthetase DF008_RS13985 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DF008_RS13995 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DF008_RS14005 ENOG4105KXX peptidase s58 dmpa DF008_RS14015 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DF008_RS14020 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DF008_RS14030 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DF008_RS14040 ENOG4108ZXQ stage ii sporulation protein r DF008_RS14045 ENOG4105DRR Transcriptional regulator, GntR family DF008_RS14050 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DF008_RS14065 ENOG4105XFA sporulation peptidase YabG DF008_RS14080 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DF008_RS14105 ENOG4105R9B Major Facilitator DF008_RS14110 ENOG4105C28 cystathionine DF008_RS14130 ENOG4105DR4 Methyltransferase DF008_RS14135 ENOG4108YBP pseudouridine synthase DF008_RS14140 ENOG4108Z5V transcriptional regulator, merr family DF008_RS14150 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS14175 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DF008_RS14185 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DF008_RS14215 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DF008_RS14230 ENOG4108VXD carboxy-peptidase DF008_RS14235 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) DF008_RS14250 ENOG4107XGZ Hydrolase DF008_RS14260 ENOG41069H0 dihydroorotase EC 3.5.2.3 DF008_RS14270 ENOG4108IJ6 ABC transporter DF008_RS14280 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DF008_RS14285 ENOG4105UQX Mate efflux family protein DF008_RS14300 ENOG4108Z5V transcriptional regulator, merr family DF008_RS14320 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DF008_RS14330 ENOG4105DDN Pentapeptide repeat-containing protein DF008_RS14335 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DF008_RS14340 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS14350 ENOG4105BZU Histidine kinase DF008_RS14360 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DF008_RS14365 ENOG4105C2X Arabinose 5-phosphate isomerase DF008_RS14385 ENOG4108W2Y isochorismatase DF008_RS14395 ENOG4105W1Y Transcriptional regulator DF008_RS14425 ENOG4107RSM transcriptional regulator DF008_RS14430 ENOG4105DD7 kinase (PfkB family DF008_RS14445 ENOG41069H0 dihydroorotase EC 3.5.2.3 DF008_RS14455 ENOG4105CK1 PTS System DF008_RS14460 ENOG4105FDP GntR family transcriptional regulator DF008_RS14465 ENOG4105VCP PTS System DF008_RS14470 ENOG4105VZJ PTS System DF008_RS14475 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DF008_RS14480 ENOG4105CK1 PTS System DF008_RS14485 ENOG4105Q2H domain protein DF008_RS14500 ENOG4106CVF DNA replication protein DF008_RS14525 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DF008_RS14535 ENOG4105CDU Replicative dna helicase DF008_RS14540 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DF008_RS14545 ENOG4105BZR domain protein DF008_RS14560 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DF008_RS14565 ENOG4108UUM single-stranded DNA-binding protein DF008_RS14570 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DF008_RS14575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DF008_RS14590 ENOG4105VFE sira family DF008_RS14605 ENOG4105C3J Cysteine desulfurase DF008_RS14610 ENOG4105FA0 parb-like partition protein DF008_RS14615 ENOG4107QJE Chromosome Partitioning Protein DF008_RS14620 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) DF008_RS14625 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DF008_RS14630 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DF008_RS14635 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DF008_RS14645 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DF008_RS14650 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DF008_RS14655 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DF008_RS14660 ENOG4105VG0 50S ribosomal protein l34 DF008_RS14665 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DF008_RS14670 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DF008_RS14680 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DF008_RS14685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DF008_RS14690 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DF008_RS14705 ENOG4105WN5 stage II sporulation protein DF008_RS14770 ENOG4105D64 Mechanosensitive ion channel DF008_RS14775 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DF008_RS14780 ENOG4108Z6B deaminase DF008_RS14795 ENOG4105C6E dna polymerase iii DF008_RS14800 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DF008_RS14805 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DF008_RS14815 ENOG4108QBV Monogalactosyldiacylglycerol synthase DF008_RS15055 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DF008_RS15060 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DF008_RS15065 ENOG4105KEX transcriptional regulator, ctsr DF008_RS15070 ENOG4108Z0C Uvrb UvrC protein DF008_RS15075 ENOG41066A3 ATP guanido phosphotransferase DF008_RS15085 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DF008_RS15090 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DF008_RS15095 ENOG4105CTP PilT protein domain protein DF008_RS15115 ENOG4105DSG hydrolase family 43 DF008_RS15125 ENOG4107RHR regulatoR DF008_RS15130 ENOG4107RUY (E1 component), alpha subunit DF008_RS15135 ENOG4105CPP Dehydrogenase, E1 component DF008_RS15140 ENOG4105C7S Dehydrogenase DF008_RS15150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS15160 ENOG41090UW PTS System DF008_RS15165 ENOG4105DT3 PTS system, galactitol-specific IIc component DF008_RS15180 ENOG4105DF9 Lipoate-protein, ligase DF008_RS15185 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DF008_RS15190 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DF008_RS15195 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DF008_RS15200 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DF008_RS15205 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DF008_RS15215 ENOG4105C8N cysteinyl-tRNA synthetase DF008_RS15220 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) DF008_RS15230 ENOG4105C2N RNA methyltransferase TrmH family group 3 DF008_RS15235 ENOG4105M0M Tetracycline resistance protein DF008_RS15240 ENOG4105QIV RNA polymerase DF008_RS15245 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DF008_RS15250 ENOG4105WDJ 50S ribosomal protein L33 DF008_RS15260 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DF008_RS15265 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DF008_RS15270 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DF008_RS15275 ENOG4108VZM 50s ribosomal protein L10 DF008_RS15280 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DF008_RS15290 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DF008_RS15295 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DF008_RS15300 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DF008_RS15305 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DF008_RS15310 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DF008_RS15315 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DF008_RS15320 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DF008_RS15325 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DF008_RS15330 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DF008_RS15335 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DF008_RS15340 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DF008_RS15345 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DF008_RS15350 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DF008_RS15355 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DF008_RS15360 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DF008_RS15365 ENOG41082SA 50s ribosomal protein l29 DF008_RS15370 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DF008_RS15375 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DF008_RS15380 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DF008_RS15385 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DF008_RS15390 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DF008_RS15395 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DF008_RS15400 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DF008_RS15405 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DF008_RS15410 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DF008_RS15415 ENOG4105VPB 50S ribosomal protein L30 DF008_RS15420 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DF008_RS15425 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DF008_RS15430 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DF008_RS15435 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DF008_RS15445 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DF008_RS15450 ENOG41067V7 50S ribosomal protein L36 DF008_RS15455 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DF008_RS15460 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DF008_RS15465 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DF008_RS15470 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DF008_RS15475 ENOG4108ZT0 50S ribosomal protein l17 DF008_RS15480 ENOG4108JJB ABC transporter DF008_RS15485 ENOG4108JJB ABC transporter DF008_RS15490 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DF008_RS15495 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DF008_RS15500 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DF008_RS15505 ENOG4108UJD 30S ribosomal protein S9 DF008_RS15650 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DF008_RS15755 ENOG4105C8B TIGR00159 family DF008_RS15770 ENOG4107RE7 phosphate butyryltransferase DF008_RS15775 ENOG4105CKM Branched-chain carboxylic acid kinase DF008_RS15805 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DF008_RS15810 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DF008_RS15815 ENOG4107RM6 sulfurtransferase DF008_RS15825 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DF008_RS15840 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DF008_RS15845 ENOG4105DFF Rod shape-determining protein mreb DF008_RS15850 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DF008_RS15855 ENOG4108ZDA Sporulation protein YyaC DF008_RS15860 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DF008_RS15865 ENOG4108K88 Membrane DF008_RS15870 ENOG4105C7H Helicase, RecD TraA family DF008_RS15875 ENOG41081UC Inherit from COG: Competence protein DF008_RS15885 ENOG4105VCP PTS System DF008_RS15890 ENOG4105VZJ PTS System DF008_RS15895 ENOG4105CK1 PTS System DF008_RS15910 ENOG4107QSE Dipeptidase DF008_RS15915 ENOG4106N3A copper homeostasis protein cutc DF008_RS15925 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DF008_RS15930 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DF008_RS15940 ENOG4105CI2 imidazolone-5-propionate hydrolase DF008_RS15955 ENOG4105K8N protein family UPF0079, ATPase DF008_RS15960 ENOG41072GX Peptidase M22 Glycoprotease DF008_RS15965 ENOG410801F ribosomal-protein-alanine acetyltransferase DF008_RS15970 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DF008_RS15975 ENOG4105C6N Formate acetyltransferase DF008_RS15980 ENOG410782T 4-hydroxyphenylacetate decarboxylase, regulatory subunit DF008_RS15985 ENOG4105F1A Pyruvate formate-lyase DF008_RS16005 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS16020 ENOG4105CH2 amidohydrolase DF008_RS16035 ENOG4105UQX Mate efflux family protein DF008_RS16040 ENOG4105C5H ABC transporter DF008_RS16045 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DF008_RS16055 ENOG41084EF Ferredoxin DF008_RS16065 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit DF008_RS16080 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DF008_RS16090 ENOG4105D82 Glutamate dehydrogenase DF008_RS16095 ENOG4105CCN Peptidase M56 DF008_RS16115 ENOG4105CXT aspartate transcarbamylase DF008_RS16120 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DF008_RS16125 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DF008_RS16130 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DF008_RS16135 ENOG4108KF8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DF008_RS16140 ENOG4105DUM transcriptional regulator, lysR family DF008_RS16155 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DF008_RS16160 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DF008_RS16165 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DF008_RS16170 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase DF008_RS16175 ENOG4105C8M UPF0272 protein DF008_RS16180 ENOG4105C8M UPF0272 protein DF008_RS16185 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DF008_RS16215 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DF008_RS16220 ENOG4105BZU Histidine kinase DF008_RS16235 ENOG4105DM4 PTS System DF008_RS16240 ENOG4108YRF PTS System DF008_RS16250 ENOG4105U0R haloacid dehalogenase-like hydrolase DF008_RS16255 ENOG4107Z36 nucleotidyl transferase DF008_RS16275 ENOG4108RS6 transposase DF008_RS16285 ENOG4108TVJ Nitroreductase DF008_RS16290 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DF008_RS16295 ENOG4105C8V SAICAR synthetase DF008_RS16305 ENOG4105CXB phosphoribosylaminoimidazole synthetase DF008_RS16310 ENOG4108V3E phosphoribosylglycinamide formyltransferase DF008_RS16315 ENOG4105DC1 bifunctional purine biosynthesis protein purh DF008_RS16320 ENOG4107QNG Phosphoribosylglycinamide synthetase DF008_RS16325 ENOG4107QIK phosphoribosylformylglycinamidine synthase DF008_RS16330 ENOG4105E4C Lytic transglycosylase catalytic DF008_RS16340 ENOG4105DD5 Flagellar motor switch protein DF008_RS16365 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DF008_RS16370 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DF008_RS16385 ENOG4107RT6 flagellar hook-associated DF008_RS16395 ENOG4105I03 Flagellin DF008_RS16400 ENOG4107R0E Glycosyl transferase, family 2 DF008_RS16405 ENOG4105EAC phosphoserine phosphatase DF008_RS16410 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) DF008_RS16425 ENOG4105CGA flagellar basal-body rod protein FlgG DF008_RS16430 ENOG4108ZC9 flagellar basal-body rod protein flgc DF008_RS16435 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DF008_RS16440 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DF008_RS16445 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DF008_RS16470 ENOG410822I Flagellar hook capping protein DF008_RS16475 ENOG4108JQA flagellar DF008_RS16485 ENOG4107R0U MotA TolQ exbB proton channel DF008_RS16490 ENOG4105ER2 Ompa motb domain protein DF008_RS16505 ENOG4105CN7 Flagellar biosynthetic protein FliP DF008_RS16515 ENOG4105D00 flagellar biosynthetic protein flhB DF008_RS16520 ENOG4105D7B Flagellar biosynthesis protein flha DF008_RS16525 ENOG4105FZW flagellar biosynthesis regulator FlhF DF008_RS16535 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DF008_RS16555 ENOG4105CGA flagellar basal-body rod protein FlgG DF008_RS16565 ENOG4105DD5 Flagellar motor switch protein DF008_RS16580 ENOG4108JB8 alcohol dehydrogenase DF008_RS16585 ENOG4105F6S Spore photoproduct lyase DF008_RS16600 ENOG4105KVH Transcriptional regulator DF008_RS16620 ENOG4105DCG PHP domain protein DF008_RS16625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS16630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS16645 ENOG4105KPI PTS system sorbose subfamily IIB component DF008_RS16650 ENOG4105ETZ PTS System DF008_RS16655 ENOG4105F3R pts system mannose fructose sorbose family iid DF008_RS16665 ENOG4107QSE Dipeptidase DF008_RS16675 ENOG41067QW Transcriptional regulator DF008_RS16680 ENOG41069JR DF008_RS16685 ENOG4105DA5 (ABC) transporter DF008_RS16705 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DF008_RS16710 ENOG4105ETE Transcriptional regulator (LacI family DF008_RS16715 ENOG4108RVA ribokinase DF008_RS16720 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DF008_RS16725 ENOG4105C2J ABC transporter DF008_RS16730 ENOG4105CNN ABC, transporter DF008_RS16735 ENOG4107S4Y M20 DapE family protein YgeY DF008_RS16745 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DF008_RS16785 ENOG4105C59 p-type ATPase DF008_RS16805 ENOG4105DQR SNARE associated Golgi DF008_RS16835 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DF008_RS16850 ENOG4105FAE von Willebrand factor, type A DF008_RS16860 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) DF008_RS16865 ENOG4108V4M Cobalt abc transporter DF008_RS16870 ENOG4108JJB ABC transporter DF008_RS16875 ENOG4105C4R Atp-dependent dna helicase DF008_RS16880 ENOG4105DFM M18 family aminopeptidase DF008_RS16890 ENOG4107ZE5 PPIases accelerate the folding of proteins DF008_RS16905 ENOG4108EKI Dehydrogenase DF008_RS16915 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS16925 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DF008_RS16930 ENOG4108NEV two component transcriptional regulator, LytTR family DF008_RS16955 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DF008_RS16980 ENOG4108U5J '-nucleotidase DF008_RS17005 ENOG4105C5Y PTS System DF008_RS17010 ENOG4105CS2 ec 3.2.1.21 DF008_RS17015 ENOG4105CID antiterminator DF008_RS17025 ENOG4105CAQ asparagine synthetase DF008_RS17040 ENOG4105C5I Dehydrogenase DF008_RS17050 ENOG4105CIZ coA-substrate-specific enzyme activase DF008_RS17055 ENOG4105CMH dehydratase DF008_RS17060 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase DF008_RS17065 ENOG4105C1G acyl-Coa dehydrogenase DF008_RS17070 ENOG4105BZJ Electron transfer flavoprotein DF008_RS17075 ENOG4105C10 Electron transfer flavoprotein DF008_RS17080 ENOG4108JUB Transcriptional regulator DF008_RS17085 ENOG4105D2N Aldolase DF008_RS17110 ENOG4105D7V transposase DF008_RS17120 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DF008_RS17145 ENOG4108JUB Transcriptional regulator DF008_RS17150 ENOG4108KR4 dihydrodipicolinate reductase DF008_RS17155 ENOG4105Z5Q DF008_RS17160 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit DF008_RS17165 ENOG4105KIJ D-ornithine aminomutase S component DF008_RS17170 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit DF008_RS17180 ENOG4106M28 alanine racemase domain protein DF008_RS17185 ENOG4105DFD Na H antiporter DF008_RS17215 ENOG4108W3Q Transcriptional regulator DF008_RS17220 ENOG4105EEM helicase DF008_RS17230 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DF008_RS17240 ENOG4105EB3 Histidine kinase DF008_RS17245 ENOG4108KXV response regulator DF008_RS17260 ENOG4108Q3X Transcriptional regulator DF008_RS17270 ENOG410667J hydrolase DF008_RS17275 ENOG4105CG3 alpha amylase, catalytic region DF008_RS17280 ENOG4105C5Y PTS System DF008_RS17290 ENOG4105NA0 Transcriptional regulator DF008_RS17295 ENOG4105JMH Nadph-dependent fmn reductase DF008_RS17325 ENOG4105DA5 (ABC) transporter DF008_RS17345 ENOG4105BZU Histidine kinase DF008_RS17350 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DF008_RS17355 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DF008_RS17360 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DF008_RS17370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DF008_RS17380 ENOG4105KPY Small multidrug resistance protein DF008_RS17385 ENOG4107T2D Phosphoribosylaminoimidazolesuccinocarboxamide synthase DF008_RS17390 ENOG4105CPQ Dehydrogenase DF008_RS17400 ENOG4108IQ3 PTS system DF008_RS17410 ENOG4105F3R pts system mannose fructose sorbose family iid DF008_RS17430 ENOG4105DZ1 carboxypeptidase DF008_RS17435 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DF008_RS17455 ENOG4105C08 Histidine kinase DF008_RS17470 ENOG4105BZU Histidine kinase DF008_RS17480 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DF008_RS17485 ENOG4105CFC Transporter DF008_RS17510 ENOG4105D29 Helix-turn-helix type 11 domain protein DF008_RS17520 ENOG4107YTP response regulator receiver protein DF008_RS17525 ENOG4107PHP CheC --inhibitor of MCP methylation DF008_RS17530 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DF008_RS17535 ENOG4108V3W Chemotaxis protein, CheW DF008_RS17540 ENOG4105BZU Histidine kinase DF008_RS17545 ENOG4105C8Q Methyl-accepting chemotaxis DF008_RS17550 ENOG4105CBS Chea signal transduction histidine kinase DF008_RS17555 ENOG4108V3W Chemotaxis protein, CheW DF008_RS17560 ENOG4105BZU Histidine kinase DF008_RS17565 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DF008_RS17615 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) DF008_RS17620 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DF008_RS17625 ENOG4105C3F Signal peptidase i DF008_RS17630 ENOG4105C3F Signal peptidase i DF008_RS17640 ENOG4105C22 threonyL-tRNA synthetase DF008_RS17645 ENOG4105CSV Glutaminase DF008_RS17655 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DF008_RS17670 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DF008_RS17675 ENOG4105DAN ATP-dependent protease DF008_RS17680 ENOG4105CSM endonuclease III DF008_RS17685 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DF008_RS17700 ENOG4107TFB basic membrane DF008_RS17715 ENOG4108UH6 UPF0754 membrane protein DF008_RS17720 ENOG4105C22 threonyL-tRNA synthetase DF008_RS17750 ENOG4105C26 Dehydrogenase DF008_RS17760 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DF008_RS17770 ENOG4105BZU Histidine kinase DF008_RS17775 ENOG4105BZU Histidine kinase DF008_RS17780 ENOG4105BZU Histidine kinase DF008_RS17835 ENOG4105BZV Phosphoadenosine phosphosulfate reductase DF008_RS17840 ENOG4105GTN ParB Domain Protein Nuclease DF008_RS17855 ENOG4105WEF catalase DF008_RS17865 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DF008_RS17925 ENOG4108NEV two component transcriptional regulator, LytTR family DF008_RS17950 ENOG4108Z5V transcriptional regulator, merr family DF008_RS17995 ENOG4105CDU Replicative dna helicase DF008_RS18015 ENOG4105BZ1 (ABC) transporter DF008_RS18020 ENOG4105IJJ transcriptional regulator, crp fnr family DF008_RS18025 ENOG4107R73 Mate efflux family protein DF008_RS18040 ENOG4105F1N DNA alkylation repair DF008_RS18095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DF008_RS18120 ENOG4105DRR Transcriptional regulator, GntR family DF008_RS18125 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DF008_RS18130 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DF008_RS18140 ENOG4106KNT transcriptional regulator DF008_RS18145 ENOG4105DM4 PTS System DF008_RS18150 ENOG4105C8I hydrolase, family 38 DF008_RS18160 ENOG4108NEV two component transcriptional regulator, LytTR family DF008_RS18205 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DF008_RS18210 ENOG4105BZ1 (ABC) transporter DF008_RS18215 ENOG4105DQ6 Transposase DF008_RS18230 ENOG4107R4J Chloride channel DF008_RS18275 ENOG4105BZU Histidine kinase DF008_RS18310 ENOG4105EMN RNA polymerase sigma factor DF008_RS18350 ENOG4107RJ1 sodium solute DF008_RS18355 ENOG4107KJX Transcriptional regulator DF008_RS18370 ENOG4105VJV 50s ribosomal protein L35 DF008_RS18375 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DF008_RS18435 ENOG4107ZYR domain protein DF008_RS18440 ENOG4108RWN rrna methyltransferase DF008_RS18445 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DF008_RS18450 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DF008_RS18465 ENOG4105CFP Peptidase U32 DF008_RS18475 ENOG4108Z4K mutator MutT protein DF008_RS18485 ENOG4105BZU Histidine kinase DF008_RS18490 ENOG4105CIN aminoacyl-histidine dipeptidase DF008_RS18495 ENOG4105C98 muts2 protein DF008_RS18500 ENOG4105EWC Purine nucleoside phosphorylase DF008_RS18505 ENOG4105C75 arginyL-tRNA synthetase