locus-tag	class	description
DF008_RS00015	COG0583	DNA-binding transcription factor activity
DF008_RS00025	COG0280	phosphate acetyltransferase
DF008_RS00030	COG1151	hydroxylamine reductase activity
DF008_RS00045	COG3404	Formiminotransferase-cyclodeaminase
DF008_RS00060	COG0646	methionine synthase
DF008_RS00060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DF008_RS00065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF008_RS00135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DF008_RS00160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DF008_RS00165	COG1360	Flagellar Motor Protein
DF008_RS00185	COG0210	DNA helicase
DF008_RS00190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF008_RS00195	COG0765	amino acid transport
DF008_RS00200	COG1126	abc transporter atp-binding protein
DF008_RS00220	COG0778	Nitroreductase
DF008_RS00225	COG5001	Diguanylate cyclase
DF008_RS00225	COG3300	MHYT domain
DF008_RS00230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DF008_RS00240	COG0530	calcium, potassium:sodium antiporter activity
DF008_RS00245	COG0513	Belongs to the DEAD box helicase family
DF008_RS00265	COG3732	PTS system glucitol sorbitol-specific
DF008_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
DF008_RS00285	COG0243	molybdopterin cofactor binding
DF008_RS00290	COG1366	Belongs to the anti-sigma-factor antagonist family
DF008_RS00295	COG2172	sigma factor antagonist activity
DF008_RS00300	COG1191	sigma factor activity
DF008_RS00310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DF008_RS00335	COG1473	amidohydrolase
DF008_RS00345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF008_RS00355	COG0750	zinc metalloprotease
DF008_RS00360	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS00365	COG0488	(ABC) transporter
DF008_RS00380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DF008_RS00395	COG1739	Uncharacterized protein family UPF0029
DF008_RS00405	COG0730	response to heat
DF008_RS00410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DF008_RS00425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DF008_RS00440	COG1024	Enoyl-CoA hydratase
DF008_RS00445	COG2610	gluconate transmembrane transporter activity
DF008_RS00460	COG2086	electron transfer activity
DF008_RS00465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DF008_RS00490	COG5001	Diguanylate cyclase
DF008_RS00490	COG3300	MHYT domain
DF008_RS00505	COG2186	Transcriptional regulator
DF008_RS00510	COG2814	Major facilitator Superfamily
DF008_RS00515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS00515	COG2190	(PTS) system
DF008_RS00515	COG1263	PTS System
DF008_RS00520	COG2723	6-phospho-beta-galactosidase activity
DF008_RS00530	COG0745	RESPONSE REGULATOR receiver
DF008_RS00535	COG2205	protein histidine kinase activity
DF008_RS00555	COG1592	Rubrerythrin
DF008_RS00565	COG2033	superoxide reductase activity
DF008_RS00570	COG0069	glutamate synthase activity
DF008_RS00590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DF008_RS00600	COG0473	3-isopropylmalate dehydrogenase activity
DF008_RS00605	COG1846	Transcriptional regulator
DF008_RS00630	COG0179	Fumarylacetoacetate (FAA) hydrolase
DF008_RS00635	COG0138	bifunctional purine biosynthesis protein purh
DF008_RS00645	COG0297	glycogen (starch) synthase activity
DF008_RS00645	COG0438	transferase activity, transferring glycosyl groups
DF008_RS00675	COG1473	amidohydrolase
DF008_RS00680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DF008_RS00695	COG0601	transmembrane transport
DF008_RS00700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF008_RS00710	COG0444	Belongs to the ABC transporter superfamily
DF008_RS00715	COG4608	Belongs to the ABC transporter superfamily
DF008_RS00720	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF008_RS00720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF008_RS00735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS00745	COG1486	melibiose metabolic process
DF008_RS00755	COG1073	alpha beta
DF008_RS00765	COG1910	domain protein
DF008_RS00770	COG0725	ABC transporter, periplasmic molybdate-binding protein
DF008_RS00775	COG4149	molybdate abc transporter
DF008_RS00780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DF008_RS00785	COG0110	maltose O-acetyltransferase activity
DF008_RS00795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DF008_RS00800	COG4120	Belongs to the binding-protein-dependent transport system permease family
DF008_RS00805	COG2984	ABC transporter substrate binding protein
DF008_RS00815	COG4120	Belongs to the binding-protein-dependent transport system permease family
DF008_RS00820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DF008_RS00820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DF008_RS00840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DF008_RS00850	COG0058	SHG alpha-glucan phosphorylase activity
DF008_RS00860	COG1802	Transcriptional regulator
DF008_RS00865	COG1982	Orn Lys Arg decarboxylase major
DF008_RS00870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DF008_RS00880	COG0010	Belongs to the arginase family
DF008_RS00930	COG1174	glycine betaine transport
DF008_RS00935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DF008_RS00965	COG0534	Mate efflux family protein
DF008_RS00970	COG0539	negative regulation of cytoplasmic translation
DF008_RS00970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DF008_RS00975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DF008_RS00985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DF008_RS01000	COG0473	3-isopropylmalate dehydrogenase activity
DF008_RS01015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DF008_RS01025	COG5001	Diguanylate cyclase
DF008_RS01025	COG3447	MASE1 domain protein
DF008_RS01025	COG5002	protein histidine kinase activity
DF008_RS01050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DF008_RS01055	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DF008_RS01065	COG0281	malic enzyme
DF008_RS01090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DF008_RS01110	COG5002	protein histidine kinase activity
DF008_RS01115	COG5001	Diguanylate cyclase
DF008_RS01120	COG4978	Transcriptional regulator
DF008_RS01120	COG0789	Transcriptional regulator
DF008_RS01130	COG1132	(ABC) transporter
DF008_RS01150	COG2364	Membrane
DF008_RS01165	COG1176	ABC-type spermidine putrescine transport system, permease component I
DF008_RS01170	COG1177	transmembrane transport
DF008_RS01175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DF008_RS01185	COG5298	Protein conserved in bacteria
DF008_RS01190	COG1215	transferase activity, transferring glycosyl groups
DF008_RS01205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DF008_RS01235	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS01240	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS01240	COG2247	cell wall binding repeat
DF008_RS01250	COG0210	DNA helicase
DF008_RS01270	COG0420	3'-5' exonuclease activity
DF008_RS01275	COG0419	ATPase involved in DNA repair
DF008_RS01280	COG4536	flavin adenine dinucleotide binding
DF008_RS01290	COG2195	Cleaves the N-terminal amino acid of tripeptides
DF008_RS01300	COG0622	Phosphoesterase
DF008_RS01305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DF008_RS01310	COG1131	(ABC) transporter
DF008_RS01330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DF008_RS01335	COG1960	acyl-CoA dehydrogenase activity
DF008_RS01340	COG2086	electron transfer activity
DF008_RS01345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DF008_RS01350	COG1024	Enoyl-CoA hydratase
DF008_RS01365	COG0564	pseudouridine synthase activity
DF008_RS01430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DF008_RS01435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS01445	COG1362	aminopeptidase activity
DF008_RS01450	COG2188	Transcriptional regulator
DF008_RS01470	COG3715	PTS system
DF008_RS01475	COG3716	PTS system mannose fructose sorbose family IID component
DF008_RS01480	COG0583	DNA-binding transcription factor activity
DF008_RS01500	COG3414	Phosphotransferase system galactitol-specific IIB component
DF008_RS01505	COG1132	(ABC) transporter
DF008_RS01515	COG1473	amidohydrolase
DF008_RS01530	COG3279	Response regulator of the LytR AlgR family
DF008_RS01545	COG1882	Formate acetyltransferase
DF008_RS01550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DF008_RS01555	COG1396	sequence-specific DNA binding
DF008_RS01580	COG3708	Transcriptional regulator
DF008_RS01580	COG2207	Transcriptional regulator
DF008_RS01600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DF008_RS01600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DF008_RS01605	COG0237	dephospho-CoA kinase activity
DF008_RS01630	COG0346	lactoylglutathione lyase activity
DF008_RS01635	COG0791	NLP P60 protein
DF008_RS01645	COG4656	Part of a membrane complex involved in electron transport
DF008_RS01650	COG4658	electron transport chain
DF008_RS01655	COG4659	FMN binding
DF008_RS01660	COG4660	Part of a membrane complex involved in electron transport
DF008_RS01665	COG4657	Part of a membrane complex involved in electron transport
DF008_RS01670	COG2878	Part of a membrane complex involved in electron transport
DF008_RS01670	COG1245	4Fe-4S binding domain
DF008_RS01685	COG1077	Cell shape determining protein MreB Mrl
DF008_RS01710	COG2894	cell division
DF008_RS01720	COG0772	Belongs to the SEDS family
DF008_RS01730	COG1695	Transcriptional regulator
DF008_RS01745	COG0426	domain, Protein
DF008_RS01760	COG1530	ribonuclease E activity
DF008_RS01790	COG0460	homoserine dehydrogenase
DF008_RS01800	COG3314	Sporulation integral membrane protein YlbJ
DF008_RS01805	COG2186	Transcriptional regulator
DF008_RS01810	COG3875	lactate racemase activity
DF008_RS01815	COG2086	electron transfer activity
DF008_RS01820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DF008_RS01825	COG0277	FAD linked oxidase domain protein
DF008_RS01850	COG2030	dehydratase
DF008_RS01870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DF008_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
DF008_RS01885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DF008_RS01890	COG3706	GGDEF domain
DF008_RS01905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DF008_RS01925	COG3854	ATPases associated with a variety of cellular activities
DF008_RS01965	COG1302	Protein conserved in bacteria
DF008_RS01975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DF008_RS01995	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DF008_RS02005	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DF008_RS02010	COG0497	DNA recombination
DF008_RS02025	COG0456	acetyltransferase
DF008_RS02030	COG0750	zinc metalloprotease
DF008_RS02050	COG0463	Glycosyl transferase, family 2
DF008_RS02065	COG0494	nUDIX hydrolase
DF008_RS02075	COG4974	Belongs to the 'phage' integrase family
DF008_RS02085	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DF008_RS02095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DF008_RS02110	COG0768	penicillin binding
DF008_RS02210	COG1191	sigma factor activity
DF008_RS02245	COG0571	ribonuclease III activity
DF008_RS02255	COG1196	nuclear chromosome segregation
DF008_RS02260	COG0552	protein localization to endoplasmic reticulum
DF008_RS02270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DF008_RS02305	COG1114	Component of the transport system for branched-chain amino acids
DF008_RS02350	COG1131	(ABC) transporter
DF008_RS02355	COG2197	response regulator
DF008_RS02360	COG4585	Histidine kinase
DF008_RS02370	COG0606	chelatase, subunit chli
DF008_RS02375	COG0758	DNA mediated transformation
DF008_RS02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DF008_RS02390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DF008_RS02400	COG1959	2 iron, 2 sulfur cluster binding
DF008_RS02410	COG0822	iron-sulfur transferase activity
DF008_RS02445	COG0735	belongs to the Fur family
DF008_RS02455	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DF008_RS02465	COG1686	Belongs to the peptidase S11 family
DF008_RS02475	COG1917	Cupin 2, conserved barrel domain protein
DF008_RS02475	COG2207	Transcriptional regulator
DF008_RS02480	COG1994	Peptidase M50
DF008_RS02485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DF008_RS02550	COG0195	Participates in both transcription termination and antitermination
DF008_RS02555	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DF008_RS02600	COG0196	riboflavin kinase activity
DF008_RS02615	COG1307	EDD domain protein, DegV family
DF008_RS02625	COG0726	polysaccharide deacetylase
DF008_RS02630	COG0612	Peptidase, M16
DF008_RS02635	COG1873	PFAM PRC-barrel domain
DF008_RS02640	COG0527	aspartate kinase activity
DF008_RS02655	COG0740	serine-type endopeptidase activity
DF008_RS02665	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DF008_RS02690	COG5001	Diguanylate cyclase
DF008_RS02715	COG0114	fumarate hydratase activity
DF008_RS02735	COG0708	Exodeoxyribonuclease III
DF008_RS02750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DF008_RS02805	COG1278	Cold shock
DF008_RS02815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DF008_RS02895	COG3299	homolog of phage Mu protein gp47
DF008_RS02900	COG3778	Protein conserved in bacteria
DF008_RS02945	COG1396	sequence-specific DNA binding
DF008_RS02950	COG2814	Major facilitator Superfamily
DF008_RS02960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DF008_RS02965	COG3273	potassium ion transport
DF008_RS02965	COG0471	metal ion transport
DF008_RS02975	COG1914	H( )-stimulated, divalent metal cation uptake system
DF008_RS02980	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DF008_RS02985	COG1984	allophanate hydrolase subunit 2
DF008_RS02990	COG1396	sequence-specific DNA binding
DF008_RS02995	COG4948	Mandelate Racemase Muconate Lactonizing
DF008_RS03040	COG1473	amidohydrolase
DF008_RS03045	COG1619	proteins homologs of microcin C7 resistance protein MccF
DF008_RS03060	COG0584	glycerophosphoryl diester phosphodiesterase
DF008_RS03080	COG0488	(ABC) transporter
DF008_RS03090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS03125	COG1242	4 iron, 4 sulfur cluster binding
DF008_RS03170	COG5002	protein histidine kinase activity
DF008_RS03170	COG3447	MASE1 domain protein
DF008_RS03170	COG5001	Diguanylate cyclase
DF008_RS03175	COG2199	diguanylate cyclase activity
DF008_RS03175	COG2203	Gaf domain
DF008_RS03185	COG4978	Transcriptional regulator
DF008_RS03185	COG0789	Transcriptional regulator
DF008_RS03200	COG1285	pathogenesis
DF008_RS03205	COG1335	isochorismatase
DF008_RS03225	COG0726	polysaccharide deacetylase
DF008_RS03230	COG1199	ATP-dependent helicase activity
DF008_RS03230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DF008_RS03235	COG0328	RNA-DNA hybrid ribonuclease activity
DF008_RS03240	COG0450	alkyl hydroperoxide reductase
DF008_RS03255	COG2720	vancomycin resistance protein
DF008_RS03275	COG1346	cytolysis
DF008_RS03280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF008_RS03290	COG2340	Cysteine-rich secretory protein family
DF008_RS03295	COG0726	polysaccharide deacetylase
DF008_RS03300	COG0512	Glutamine amidotransferase of anthranilate synthase
DF008_RS03305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DF008_RS03310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DF008_RS03325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DF008_RS03330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DF008_RS03335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DF008_RS03340	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DF008_RS03345	COG0358	DNA primase activity
DF008_RS03350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DF008_RS03355	COG2384	SAM-dependent methyltransferase
DF008_RS03360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DF008_RS03365	COG0655	NAD(P)H dehydrogenase (quinone) activity
DF008_RS03385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS03400	COG5002	protein histidine kinase activity
DF008_RS03400	COG3850	Histidine kinase
DF008_RS03405	COG1136	(ABC) transporter
DF008_RS03405	COG0577	efflux transmembrane transporter activity
DF008_RS03435	COG1132	(ABC) transporter
DF008_RS03440	COG1132	(ABC) transporter
DF008_RS03445	COG1773	rubredoxin
DF008_RS03445	COG1592	Rubrerythrin
DF008_RS03450	COG0412	Dienelactone hydrolase
DF008_RS03485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF008_RS03525	COG2011	ABC-type metal ion transport system permease component
DF008_RS03535	COG5002	protein histidine kinase activity
DF008_RS03545	COG1396	sequence-specific DNA binding
DF008_RS03550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DF008_RS03555	COG4086	secreted protein
DF008_RS03570	COG0728	peptidoglycan biosynthetic process
DF008_RS03600	COG1131	(ABC) transporter
DF008_RS03610	COG0534	Mate efflux family protein
DF008_RS03625	COG0348	domain, Protein
DF008_RS03625	COG3901	Regulator of nitric oxide reductase transcription
DF008_RS03665	COG5001	Diguanylate cyclase
DF008_RS03675	COG4978	Transcriptional regulator
DF008_RS03675	COG0789	Transcriptional regulator
DF008_RS03680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DF008_RS03700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DF008_RS03705	COG0726	polysaccharide deacetylase
DF008_RS03715	COG1773	rubredoxin
DF008_RS03715	COG1592	Rubrerythrin
DF008_RS03720	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DF008_RS03730	COG0577	efflux transmembrane transporter activity
DF008_RS03735	COG0577	efflux transmembrane transporter activity
DF008_RS03735	COG1136	(ABC) transporter
DF008_RS03745	COG2205	protein histidine kinase activity
DF008_RS03750	COG0745	RESPONSE REGULATOR receiver
DF008_RS03755	COG1136	(ABC) transporter
DF008_RS03760	COG0577	efflux transmembrane transporter activity
DF008_RS03765	COG0405	Gamma-glutamyltransferase
DF008_RS03780	COG0493	'glutamate synthase
DF008_RS03780	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DF008_RS03790	COG1136	(ABC) transporter
DF008_RS03795	COG0577	efflux transmembrane transporter activity
DF008_RS03835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DF008_RS03845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DF008_RS03855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DF008_RS03870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DF008_RS03870	COG0140	phosphoribosyl-ATP diphosphatase activity
DF008_RS03875	COG0531	amino acid
DF008_RS03890	COG1595	DNA-templated transcription, initiation
DF008_RS03905	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DF008_RS03925	COG0028	Belongs to the TPP enzyme family
DF008_RS03930	COG0582	viral genome integration into host DNA
DF008_RS03960	COG3617	BRO family, N-terminal domain
DF008_RS03995	COG0629	single-stranded DNA binding
DF008_RS04020	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
DF008_RS04060	COG5484	DNA packaging
DF008_RS04070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DF008_RS04185	COG4193	domain, Protein
DF008_RS04195	COG3628	GPW Gp25 family protein
DF008_RS04200	COG3299	homolog of phage Mu protein gp47
DF008_RS04280	COG1388	LysM domain
DF008_RS04280	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS04300	COG3546	catalase activity
DF008_RS04305	COG1331	Highly conserved protein containing a thioredoxin domain
DF008_RS04315	COG2267	carboxylic ester hydrolase activity
DF008_RS04330	COG1388	LysM domain
DF008_RS04330	COG3584	3D domain protein
DF008_RS04340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DF008_RS04345	COG1295	ribonuclease BN
DF008_RS04350	COG5002	protein histidine kinase activity
DF008_RS04355	COG0460	homoserine dehydrogenase
DF008_RS04370	COG2267	carboxylic ester hydrolase activity
DF008_RS04375	COG5566	PFAM Mor transcription activator
DF008_RS04385	COG2971	BadF BadG BcrA BcrD
DF008_RS04395	COG1129	ABC transporter
DF008_RS04400	COG1172	Belongs to the binding-protein-dependent transport system permease family
DF008_RS04410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF008_RS04420	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DF008_RS04425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DF008_RS04435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DF008_RS04440	COG1045	serine acetyltransferase
DF008_RS04445	COG1141	Ferredoxin
DF008_RS04450	COG0024	Methionine aminopeptidase
DF008_RS04465	COG0351	phosphomethylpyrimidine kinase
DF008_RS04480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS04500	COG1725	Transcriptional regulator
DF008_RS04505	COG1131	(ABC) transporter
DF008_RS04530	COG0402	S-adenosylhomocysteine deaminase activity
DF008_RS04540	COG4555	ABC transporter
DF008_RS04545	COG1668	transmembrane transport
DF008_RS04550	COG5001	Diguanylate cyclase
DF008_RS04550	COG3300	MHYT domain
DF008_RS04555	COG1725	Transcriptional regulator
DF008_RS04560	COG1131	(ABC) transporter
DF008_RS04575	COG0668	transmembrane transport
DF008_RS04585	COG0426	domain, Protein
DF008_RS04600	COG1181	Belongs to the D-alanine--D-alanine ligase family
DF008_RS04605	COG1876	peptidase activity
DF008_RS04630	COG0367	asparagine synthase
DF008_RS04650	COG2310	stress, protein
DF008_RS04665	COG3853	Toxic anion resistance protein (TelA)
DF008_RS04695	COG5505	Protein of unknown function (DUF819)
DF008_RS04705	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF008_RS04710	COG4605	iron ion homeostasis
DF008_RS04715	COG4604	ABC transporter, ATP-binding protein
DF008_RS04720	COG4607	ABC-type enterochelin transport system periplasmic component
DF008_RS04725	COG5001	Diguanylate cyclase
DF008_RS04725	COG3706	GGDEF domain
DF008_RS04725	COG4251	negative regulation of phosphorylation
DF008_RS04725	COG2203	Gaf domain
DF008_RS04740	COG0095	Lipoate-protein ligase
DF008_RS04745	COG1757	Na H antiporter
DF008_RS04760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DF008_RS04765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DF008_RS04770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DF008_RS04800	COG0402	S-adenosylhomocysteine deaminase activity
DF008_RS04815	COG1396	sequence-specific DNA binding
DF008_RS04825	COG0584	glycerophosphoryl diester phosphodiesterase
DF008_RS04845	COG1131	(ABC) transporter
DF008_RS04855	COG0745	RESPONSE REGULATOR receiver
DF008_RS04860	COG2205	protein histidine kinase activity
DF008_RS04875	COG1733	regulation of RNA biosynthetic process
DF008_RS04905	COG1309	transcriptional regulator
DF008_RS04940	COG0745	RESPONSE REGULATOR receiver
DF008_RS04945	COG5002	protein histidine kinase activity
DF008_RS04950	COG3118	belongs to the thioredoxin family
DF008_RS04975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DF008_RS04980	COG1115	amino acid carrier protein
DF008_RS04990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DF008_RS04990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DF008_RS05005	COG0514	ATP-dependent DNA helicase (RecQ)
DF008_RS05030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DF008_RS05040	COG1288	antiporter activity
DF008_RS05065	COG0521	Mo-molybdopterin cofactor biosynthetic process
DF008_RS05075	COG0315	cyclic pyranopterin monophosphate synthase activity
DF008_RS05145	COG1283	sodium-dependent phosphate transmembrane transporter activity
DF008_RS05170	COG5012	cobalamin binding
DF008_RS05175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DF008_RS05185	COG1011	Hydrolase
DF008_RS05190	COG1917	Cupin 2, conserved barrel domain protein
DF008_RS05190	COG1396	sequence-specific DNA binding
DF008_RS05195	COG2610	gluconate transmembrane transporter activity
DF008_RS05200	COG5002	protein histidine kinase activity
DF008_RS05205	COG2204	response regulator
DF008_RS05245	COG0786	glutamate:sodium symporter activity
DF008_RS05260	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DF008_RS05265	COG1924	4 iron, 4 sulfur cluster binding
DF008_RS05270	COG2385	sporulation resulting in formation of a cellular spore
DF008_RS05270	COG2247	cell wall binding repeat
DF008_RS05280	COG1309	transcriptional regulator
DF008_RS05305	COG0242	peptide deformylase activity
DF008_RS05340	COG3326	Membrane
DF008_RS05350	COG0494	nUDIX hydrolase
DF008_RS05400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF008_RS05405	COG0765	amino acid transport
DF008_RS05415	COG1393	Belongs to the ArsC family
DF008_RS05425	COG1606	tRNA processing
DF008_RS05430	COG0116	Belongs to the methyltransferase superfamily
DF008_RS05445	COG5002	protein histidine kinase activity
DF008_RS05445	COG3850	Histidine kinase
DF008_RS05465	COG0789	Transcriptional regulator
DF008_RS05475	COG2323	membrane
DF008_RS05490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DF008_RS05510	COG2221	Nitrite and sulphite reductase 4Fe-4S
DF008_RS05515	COG0446	pyridine nucleotide-disulphide oxidoreductase
DF008_RS05520	COG0583	DNA-binding transcription factor activity
DF008_RS05535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF008_RS05550	COG1609	Transcriptional regulator
DF008_RS05560	COG1621	beta-fructofuranosidase activity
DF008_RS05565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DF008_RS05570	COG2801	Transposase and inactivated derivatives
DF008_RS05590	COG2814	Major facilitator Superfamily
DF008_RS05620	COG0406	alpha-ribazole phosphatase activity
DF008_RS05625	COG2081	HI0933 family
DF008_RS05635	COG0204	Acyl-transferase
DF008_RS05655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DF008_RS05675	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DF008_RS05680	COG1846	Transcriptional regulator
DF008_RS05685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DF008_RS05690	COG2205	protein histidine kinase activity
DF008_RS05700	COG0598	Magnesium transport protein CorA
DF008_RS05710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DF008_RS05715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DF008_RS05725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DF008_RS05730	COG1605	Chorismate mutase
DF008_RS05730	COG0077	Prephenate dehydratase
DF008_RS05735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DF008_RS05745	COG0287	Prephenate dehydrogenase
DF008_RS05755	COG3706	GGDEF domain
DF008_RS05790	COG2207	Transcriptional regulator
DF008_RS05790	COG3708	Transcriptional regulator
DF008_RS05830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DF008_RS05835	COG2226	methyltransferase
DF008_RS05840	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DF008_RS05870	COG2131	deaminase
DF008_RS05890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF008_RS05910	COG4810	utilization protein
DF008_RS05935	COG4303	Ethanolamine ammonia lyase large subunit
DF008_RS05945	COG4816	utilization protein
DF008_RS05950	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DF008_RS05955	COG1012	belongs to the aldehyde dehydrogenase family
DF008_RS05955	COG1454	alcohol dehydrogenase
DF008_RS05960	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DF008_RS05980	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
DF008_RS05990	COG3192	ethanolamine utilization protein
DF008_RS05995	COG4766	ethanolamine catabolic process
DF008_RS06015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DF008_RS06020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF008_RS06025	COG1116	anion transmembrane transporter activity
DF008_RS06050	COG4974	Belongs to the 'phage' integrase family
DF008_RS06065	COG2359	stage V sporulation protein S
DF008_RS06070	COG0825	malonyl-CoA metabolic process
DF008_RS06080	COG0439	Biotin carboxylase
DF008_RS06085	COG0511	ligase activity, forming carbon-carbon bonds
DF008_RS06130	COG1136	(ABC) transporter
DF008_RS06140	COG2205	protein histidine kinase activity
DF008_RS06145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF008_RS06150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF008_RS06170	COG1136	(ABC) transporter
DF008_RS06180	COG0745	RESPONSE REGULATOR receiver
DF008_RS06190	COG0745	RESPONSE REGULATOR receiver
DF008_RS06195	COG2205	protein histidine kinase activity
DF008_RS06200	COG1136	(ABC) transporter
DF008_RS06200	COG0577	efflux transmembrane transporter activity
DF008_RS06235	COG1811	Na channel or pump
DF008_RS06240	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DF008_RS06255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF008_RS06260	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DF008_RS06275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DF008_RS06285	COG1116	anion transmembrane transporter activity
DF008_RS06290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DF008_RS06295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF008_RS06310	COG1733	regulation of RNA biosynthetic process
DF008_RS06320	COG0494	nUDIX hydrolase
DF008_RS06335	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS06335	COG2247	cell wall binding repeat
DF008_RS06395	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DF008_RS06420	COG0730	response to heat
DF008_RS06425	COG2207	Transcriptional regulator
DF008_RS06430	COG0596	Alpha beta hydrolase
DF008_RS06435	COG1309	transcriptional regulator
DF008_RS06450	COG1404	Belongs to the peptidase S8 family
DF008_RS06460	COG1309	transcriptional regulator
DF008_RS06505	COG2207	Transcriptional regulator
DF008_RS06530	COG1725	Transcriptional regulator
DF008_RS06555	COG1794	racemase activity, acting on amino acids and derivatives
DF008_RS06565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DF008_RS06570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DF008_RS06580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DF008_RS06590	COG0456	acetyltransferase
DF008_RS06620	COG3655	Transcriptional regulator
DF008_RS06635	COG1737	Transcriptional regulator
DF008_RS06640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DF008_RS06645	COG1187	pseudouridine synthase activity
DF008_RS06650	COG0628	permease
DF008_RS06660	COG0019	diaminopimelate decarboxylase activity
DF008_RS06665	COG0527	aspartate kinase activity
DF008_RS06700	COG1597	lipid kinase activity
DF008_RS06730	COG0582	viral genome integration into host DNA
DF008_RS06740	COG0488	(ABC) transporter
DF008_RS06755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DF008_RS06765	COG2080	2 iron, 2 sulfur cluster binding
DF008_RS06765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DF008_RS06775	COG2233	PERMEase
DF008_RS06790	COG0167	dihydroorotate dehydrogenase activity
DF008_RS06795	COG0402	S-adenosylhomocysteine deaminase activity
DF008_RS06815	COG0402	S-adenosylhomocysteine deaminase activity
DF008_RS06840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DF008_RS06850	COG0402	S-adenosylhomocysteine deaminase activity
DF008_RS06875	COG1401	restriction endodeoxyribonuclease activity
DF008_RS06890	COG4708	membrane
DF008_RS06900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DF008_RS06900	COG2080	2 iron, 2 sulfur cluster binding
DF008_RS06935	COG1131	(ABC) transporter
DF008_RS06945	COG2252	PERMEase
DF008_RS06950	COG0534	Mate efflux family protein
DF008_RS06960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DF008_RS06965	COG1349	DNA-binding transcription factor activity
DF008_RS06975	COG5002	protein histidine kinase activity
DF008_RS06980	COG0745	RESPONSE REGULATOR receiver
DF008_RS07005	COG0492	ferredoxin-NADP+ reductase activity
DF008_RS07045	COG1247	-acetyltransferase
DF008_RS07070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DF008_RS07075	COG0750	zinc metalloprotease
DF008_RS07100	COG4589	Belongs to the CDS family
DF008_RS07135	COG1686	Belongs to the peptidase S11 family
DF008_RS07150	COG1971	Probably functions as a manganese efflux pump
DF008_RS07155	COG1193	negative regulation of DNA recombination
DF008_RS07170	COG2720	vancomycin resistance protein
DF008_RS07190	COG1363	Peptidase, m42
DF008_RS07200	COG1160	GTP binding
DF008_RS07205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DF008_RS07255	COG0039	L-malate dehydrogenase activity
DF008_RS07265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DF008_RS07265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DF008_RS07275	COG1151	hydroxylamine reductase activity
DF008_RS07295	COG0437	4 iron, 4 sulfur cluster binding
DF008_RS07305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DF008_RS07310	COG0596	Alpha beta hydrolase
DF008_RS07320	COG0513	Belongs to the DEAD box helicase family
DF008_RS07340	COG1705	Flagellar rod assembly protein muramidase FlgJ
DF008_RS07345	COG1554	hydrolase, family 65, central catalytic
DF008_RS07350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DF008_RS07360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DF008_RS07370	COG2247	cell wall binding repeat
DF008_RS07370	COG2385	sporulation resulting in formation of a cellular spore
DF008_RS07380	COG1528	Iron-storage protein
DF008_RS07385	COG1042	CoA-binding domain protein
DF008_RS07385	COG0045	succinate-CoA ligase (ADP-forming) activity
DF008_RS07385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF008_RS07400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DF008_RS07400	COG0674	pyruvate-flavodoxin oxidoreductase activity
DF008_RS07410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DF008_RS07425	COG1309	transcriptional regulator
DF008_RS07430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DF008_RS07435	COG0628	permease
DF008_RS07440	COG1012	belongs to the aldehyde dehydrogenase family
DF008_RS07455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DF008_RS07480	COG0288	reversible hydration of carbon dioxide
DF008_RS07530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF008_RS07560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DF008_RS07580	COG2221	Nitrite and sulphite reductase 4Fe-4S
DF008_RS07620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DF008_RS07625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DF008_RS07645	COG4251	negative regulation of phosphorylation
DF008_RS07645	COG2203	Gaf domain
DF008_RS07645	COG3706	GGDEF domain
DF008_RS07645	COG5001	Diguanylate cyclase
DF008_RS07650	COG0017	Asparaginyl-tRNA synthetase
DF008_RS07660	COG1404	Belongs to the peptidase S8 family
DF008_RS07665	COG1404	Belongs to the peptidase S8 family
DF008_RS07695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS07700	COG1794	racemase activity, acting on amino acids and derivatives
DF008_RS07720	COG0662	Cupin 2, conserved barrel domain protein
DF008_RS07725	COG3104	oligopeptide transport
DF008_RS07730	COG0006	proline dipeptidase activity
DF008_RS07735	COG3104	oligopeptide transport
DF008_RS07740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DF008_RS07755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DF008_RS07755	COG0723	plastoquinol--plastocyanin reductase activity
DF008_RS07760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS07760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS07760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS07765	COG1105	Belongs to the carbohydrate kinase PfkB family
DF008_RS07770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS07770	COG3711	transcriptional antiterminator
DF008_RS07775	COG2365	Tyrosine phosphatase family
DF008_RS07795	COG1115	amino acid carrier protein
DF008_RS07805	COG0235	Class ii aldolase
DF008_RS07810	COG1063	alcohol dehydrogenase
DF008_RS07815	COG3775	system Galactitol-specific IIC component
DF008_RS07820	COG3414	Phosphotransferase system galactitol-specific IIB component
DF008_RS07825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS07825	COG2213	PTS system mannitol-specific
DF008_RS07830	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF008_RS07830	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF008_RS07840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS07845	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DF008_RS07855	COG5002	protein histidine kinase activity
DF008_RS07905	COG3617	BRO family, N-terminal domain
DF008_RS07965	COG3620	sequence-specific DNA binding
DF008_RS07990	COG3842	ATPase activity
DF008_RS08010	COG2205	protein histidine kinase activity
DF008_RS08015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DF008_RS08020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DF008_RS08025	COG0698	ribose 5-phosphate isomerase
DF008_RS08030	COG3958	Transketolase
DF008_RS08035	COG3959	Transketolase, thiamine diphosphate binding domain
DF008_RS08050	COG3775	system Galactitol-specific IIC component
DF008_RS08055	COG3414	Phosphotransferase system galactitol-specific IIB component
DF008_RS08065	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF008_RS08065	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF008_RS08080	COG0246	Mannitol dehydrogenase
DF008_RS08085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS08090	COG3711	transcriptional antiterminator
DF008_RS08100	COG0516	GMP reductase activity
DF008_RS08100	COG0517	IMP dehydrogenase activity
DF008_RS08105	COG3853	Toxic anion resistance protein (TelA)
DF008_RS08115	COG1454	alcohol dehydrogenase
DF008_RS08120	COG0427	acetyl-CoA hydrolase
DF008_RS08135	COG1012	belongs to the aldehyde dehydrogenase family
DF008_RS08140	COG0427	acetyl-CoA hydrolase
DF008_RS08145	COG0490	domain, Protein
DF008_RS08145	COG2985	domain, Protein
DF008_RS08145	COG0490	domain, Protein
DF008_RS08145	COG2985	domain, Protein
DF008_RS08150	COG0583	DNA-binding transcription factor activity
DF008_RS08160	COG0006	proline dipeptidase activity
DF008_RS08190	COG3118	belongs to the thioredoxin family
DF008_RS08210	COG0561	phosphatase activity
DF008_RS08225	COG1116	anion transmembrane transporter activity
DF008_RS08235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF008_RS08275	COG0157	Belongs to the NadC ModD family
DF008_RS08290	COG1966	Carbon starvation protein
DF008_RS08305	COG0628	permease
DF008_RS08315	COG2364	Membrane
DF008_RS08320	COG3426	butyrate kinase activity
DF008_RS08345	COG2199	diguanylate cyclase activity
DF008_RS08350	COG2199	diguanylate cyclase activity
DF008_RS08350	COG2203	Gaf domain
DF008_RS08410	COG0072	phenylalanine-tRNA ligase activity
DF008_RS08410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF008_RS08415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DF008_RS08420	COG2176	DNA-directed DNA polymerase activity
DF008_RS08440	COG0037	tRNA processing
DF008_RS08455	COG3546	catalase activity
DF008_RS08460	COG3103	Sh3 type 3 domain protein
DF008_RS08460	COG1388	LysM domain
DF008_RS08460	COG0791	NLP P60 protein
DF008_RS08470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DF008_RS08470	COG0551	DNA topoisomerase type I activity
DF008_RS08500	COG0574	Belongs to the PEP-utilizing enzyme family
DF008_RS08500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DF008_RS08510	COG0517	IMP dehydrogenase activity
DF008_RS08530	COG3711	transcriptional antiterminator
DF008_RS08530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS08535	COG3732	PTS system glucitol sorbitol-specific
DF008_RS08545	COG2207	Transcriptional regulator
DF008_RS08560	COG1115	amino acid carrier protein
DF008_RS08565	COG2223	nitrite transmembrane transporter activity
DF008_RS08570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS08575	COG0280	phosphate acetyltransferase
DF008_RS08595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DF008_RS08595	COG0674	pyruvate-flavodoxin oxidoreductase activity
DF008_RS08605	COG1414	Transcriptional regulator
DF008_RS08640	COG2239	Acts as a magnesium transporter
DF008_RS08650	COG0295	cytidine deaminase activity
DF008_RS08655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DF008_RS08665	COG1702	phosphate starvation-inducible protein PhoH
DF008_RS08685	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DF008_RS08690	COG1610	YqeY-like protein
DF008_RS08700	COG0537	adenosine 5'-monophosphoramidase activity
DF008_RS08705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DF008_RS08710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DF008_RS08715	COG2264	protein methyltransferase activity
DF008_RS08745	COG3842	ATPase activity
DF008_RS08750	COG2508	Transcriptional regulator
DF008_RS08755	COG0477	Major facilitator Superfamily
DF008_RS08760	COG1940	carbohydrate kinase activity
DF008_RS08790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DF008_RS08795	COG0531	amino acid
DF008_RS08800	COG0617	tRNA 3'-terminal CCA addition
DF008_RS08845	COG0658	competence protein
DF008_RS08845	COG2333	competence protein COMEC
DF008_RS08865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DF008_RS08875	COG3584	3D domain protein
DF008_RS08875	COG1388	LysM domain
DF008_RS08895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF008_RS08900	COG0006	proline dipeptidase activity
DF008_RS08905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS08910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS08920	COG3711	transcriptional antiterminator
DF008_RS08920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS08925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF008_RS08930	COG1482	cell wall glycoprotein biosynthetic process
DF008_RS08935	COG5002	protein histidine kinase activity
DF008_RS08955	COG1555	photosystem II stabilization
DF008_RS08960	COG1686	Belongs to the peptidase S11 family
DF008_RS08975	COG0561	phosphatase activity
DF008_RS08985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DF008_RS08990	COG1876	peptidase activity
DF008_RS08995	COG1309	transcriptional regulator
DF008_RS09000	COG2814	Major facilitator Superfamily
DF008_RS09010	COG4977	sequence-specific DNA binding
DF008_RS09020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS09020	COG1263	PTS System
DF008_RS09025	COG3711	transcriptional antiterminator
DF008_RS09030	COG1263	PTS System
DF008_RS09030	COG2190	(PTS) system
DF008_RS09030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS09035	COG0251	oxidation-reduction process
DF008_RS09040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DF008_RS09075	COG0582	viral genome integration into host DNA
DF008_RS09095	COG0799	negative regulation of ribosome biogenesis
DF008_RS09100	COG1713	HD superfamily hydrolase involved in NAD metabolism
DF008_RS09115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DF008_RS09120	COG1309	transcriptional regulator
DF008_RS09145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DF008_RS09155	COG1136	(ABC) transporter
DF008_RS09155	COG0577	efflux transmembrane transporter activity
DF008_RS09165	COG0745	RESPONSE REGULATOR receiver
DF008_RS09170	COG0737	Belongs to the 5'-nucleotidase family
DF008_RS09185	COG0446	pyridine nucleotide-disulphide oxidoreductase
DF008_RS09190	COG1823	symporter activity
DF008_RS09225	COG0395	ABC-type sugar transport system, permease component
DF008_RS09245	COG4821	SIS domain
DF008_RS09275	COG0742	ribosomal rna small subunit methyltransferase
DF008_RS09280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DF008_RS09285	COG1461	Dihydroxyacetone kinase
DF008_RS09290	COG1302	Protein conserved in bacteria
DF008_RS09310	COG0789	Transcriptional regulator
DF008_RS09315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS09315	COG3711	transcriptional antiterminator
DF008_RS09320	COG3711	transcriptional antiterminator
DF008_RS09320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS09325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS09330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS09335	COG0383	alpha-mannosidase activity
DF008_RS09360	COG1564	THIamine pyrophosphokinase
DF008_RS09365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DF008_RS09370	COG1162	GTPase activity
DF008_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
DF008_RS09380	COG0515	serine threonine protein kinase
DF008_RS09380	COG2815	serine threonine protein kinase
DF008_RS09395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DF008_RS09395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DF008_RS09400	COG2738	Putative neutral zinc metallopeptidase
DF008_RS09415	COG0242	peptide deformylase activity
DF008_RS09420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DF008_RS09425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DF008_RS09440	COG1561	YicC-like family, N-terminal region
DF008_RS09445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DF008_RS09460	COG0488	(ABC) transporter
DF008_RS09475	COG0564	pseudouridine synthase activity
DF008_RS09485	COG0726	polysaccharide deacetylase
DF008_RS09490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DF008_RS09495	COG1966	Carbon starvation protein
DF008_RS09500	COG3279	Response regulator of the LytR AlgR family
DF008_RS09505	COG3275	phosphorelay sensor kinase activity
DF008_RS09515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DF008_RS09520	COG0531	amino acid
DF008_RS09525	COG0006	proline dipeptidase activity
DF008_RS09530	COG1307	EDD domain protein, DegV family
DF008_RS09545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF008_RS09550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DF008_RS09560	COG2302	S4 RNA-binding domain
DF008_RS09575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DF008_RS09595	COG3830	Belongs to the UPF0237 family
DF008_RS09610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DF008_RS09620	COG1160	GTP binding
DF008_RS09645	COG5002	protein histidine kinase activity
DF008_RS09650	COG0745	RESPONSE REGULATOR receiver
DF008_RS09665	COG1873	PFAM PRC-barrel domain
DF008_RS09670	COG1191	sigma factor activity
DF008_RS09675	COG1191	sigma factor activity
DF008_RS09690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DF008_RS09695	COG3856	small basic protein
DF008_RS09720	COG0772	Belongs to the SEDS family
DF008_RS09735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DF008_RS09740	COG0768	penicillin binding
DF008_RS09760	COG0612	Peptidase, M16
DF008_RS09770	COG0012	GTP binding
DF008_RS09790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS09790	COG1263	PTS System
DF008_RS09790	COG2190	(PTS) system
DF008_RS09795	COG3711	transcriptional antiterminator
DF008_RS09800	COG0025	NhaP-type Na H and K H
DF008_RS09805	COG4608	Belongs to the ABC transporter superfamily
DF008_RS09810	COG0444	Belongs to the ABC transporter superfamily
DF008_RS09820	COG0601	transmembrane transport
DF008_RS09825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF008_RS09830	COG0583	DNA-binding transcription factor activity
DF008_RS09840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DF008_RS09850	COG1028	Short-chain dehydrogenase reductase Sdr
DF008_RS09855	COG2610	gluconate transmembrane transporter activity
DF008_RS09860	COG2340	Cysteine-rich secretory protein family
DF008_RS09910	COG2081	HI0933 family
DF008_RS09915	COG0671	phosphoesterase, PA-phosphatase related
DF008_RS09925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DF008_RS09945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF008_RS09950	COG1473	amidohydrolase
DF008_RS09960	COG3366	ferrous iron transmembrane transporter activity
DF008_RS09985	COG2252	PERMEase
DF008_RS09990	COG0402	S-adenosylhomocysteine deaminase activity
DF008_RS10000	COG2271	Major facilitator Superfamily
DF008_RS10020	COG0583	DNA-binding transcription factor activity
DF008_RS10030	COG1376	ErfK ybiS ycfS ynhG family protein
DF008_RS10035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DF008_RS10040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DF008_RS10065	COG4509	Sortase family
DF008_RS10085	COG0726	polysaccharide deacetylase
DF008_RS10090	COG3069	C4-dicarboxylate transmembrane transporter activity
DF008_RS10095	COG5002	protein histidine kinase activity
DF008_RS10095	COG0642	Histidine kinase
DF008_RS10100	COG0745	RESPONSE REGULATOR receiver
DF008_RS10140	COG1937	Protein conserved in bacteria
DF008_RS10155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF008_RS10160	COG1757	Na H antiporter
DF008_RS10170	COG2247	cell wall binding repeat
DF008_RS10170	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS10175	COG0583	DNA-binding transcription factor activity
DF008_RS10180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DF008_RS10200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DF008_RS10205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF008_RS10215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DF008_RS10225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DF008_RS10225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DF008_RS10265	COG5001	Diguanylate cyclase
DF008_RS10270	COG3706	GGDEF domain
DF008_RS10280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS10305	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS10310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DF008_RS10320	COG0561	phosphatase activity
DF008_RS10325	COG1316	TRANSCRIPTIONal
DF008_RS10330	COG1316	TRANSCRIPTIONal
DF008_RS10335	COG1649	PFAM Uncharacterised BCR, COG1649
DF008_RS10350	COG0438	transferase activity, transferring glycosyl groups
DF008_RS10355	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DF008_RS10360	COG1215	transferase activity, transferring glycosyl groups
DF008_RS10370	COG1215	transferase activity, transferring glycosyl groups
DF008_RS10375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DF008_RS10375	COG1215	transferase activity, transferring glycosyl groups
DF008_RS10380	COG1216	Glycosyl transferase, family 2
DF008_RS10400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DF008_RS10405	COG0728	peptidoglycan biosynthetic process
DF008_RS10410	COG2247	cell wall binding repeat
DF008_RS10410	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS10415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DF008_RS10420	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS10430	COG2247	cell wall binding repeat
DF008_RS10430	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS10440	COG2246	polysaccharide biosynthetic process
DF008_RS10495	COG2247	cell wall binding repeat
DF008_RS10495	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS10535	COG0632	four-way junction helicase activity
DF008_RS10565	COG2610	gluconate transmembrane transporter activity
DF008_RS10570	COG2084	Dehydrogenase
DF008_RS10590	COG1132	(ABC) transporter
DF008_RS10610	COG0700	Nucleoside recognition
DF008_RS10615	COG3366	ferrous iron transmembrane transporter activity
DF008_RS10620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF008_RS10650	COG0436	Aminotransferase
DF008_RS10655	COG0697	spore germination
DF008_RS10670	COG1230	cation diffusion facilitator family transporter
DF008_RS10685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DF008_RS10690	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DF008_RS10700	COG3949	Membrane
DF008_RS10715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DF008_RS10730	COG0604	alcohol dehydrogenase
DF008_RS10740	COG1592	Rubrerythrin
DF008_RS10745	COG0789	Transcriptional regulator
DF008_RS10755	COG1664	Polymer-forming cytoskeletal
DF008_RS10765	COG1349	DNA-binding transcription factor activity
DF008_RS10770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DF008_RS10775	COG1696	Membrane protein involved in D-alanine export
DF008_RS10780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DF008_RS10790	COG0673	inositol 2-dehydrogenase activity
DF008_RS10800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DF008_RS10805	COG1253	flavin adenine dinucleotide binding
DF008_RS10810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DF008_RS10830	COG3829	transcription factor binding
DF008_RS10830	COG3290	protein histidine kinase activity
DF008_RS10835	COG2267	carboxylic ester hydrolase activity
DF008_RS10845	COG0312	modulator of DNA gyrase
DF008_RS10850	COG0312	modulator of DNA gyrase
DF008_RS10875	COG2721	sulfolactate sulfo-lyase activity
DF008_RS10890	COG1120	ATPase activity
DF008_RS10895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF008_RS10900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF008_RS10915	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF008_RS10920	COG3394	polysaccharide catabolic process
DF008_RS10925	COG1486	melibiose metabolic process
DF008_RS10930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS10940	COG2188	Transcriptional regulator
DF008_RS10945	COG0366	Alpha amylase catalytic
DF008_RS10950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS10950	COG1263	PTS System
DF008_RS10960	COG2188	Transcriptional regulator
DF008_RS10970	COG3842	ATPase activity
DF008_RS10975	COG1840	ABC-type Fe3 transport system, periplasmic component
DF008_RS11010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DF008_RS11015	COG1269	ATP hydrolysis coupled proton transport
DF008_RS11040	COG3300	MHYT domain
DF008_RS11040	COG5001	Diguanylate cyclase
DF008_RS11045	COG1012	belongs to the aldehyde dehydrogenase family
DF008_RS11045	COG1454	alcohol dehydrogenase
DF008_RS11055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DF008_RS11065	COG0318	PFAM AMP-dependent synthetase and ligase
DF008_RS11070	COG0183	Belongs to the thiolase family
DF008_RS11075	COG1268	BioY protein
DF008_RS11090	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DF008_RS11105	COG1203	CRISPR-associated helicase, Cas3
DF008_RS11135	COG0577	efflux transmembrane transporter activity
DF008_RS11140	COG1136	(ABC) transporter
DF008_RS11150	COG2205	protein histidine kinase activity
DF008_RS11155	COG0745	RESPONSE REGULATOR receiver
DF008_RS11170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF008_RS11185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DF008_RS11190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DF008_RS11200	COG1120	ATPase activity
DF008_RS11205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF008_RS11225	COG2205	protein histidine kinase activity
DF008_RS11230	COG0745	RESPONSE REGULATOR receiver
DF008_RS11235	COG0577	efflux transmembrane transporter activity
DF008_RS11240	COG1136	(ABC) transporter
DF008_RS11255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DF008_RS11260	COG0179	Fumarylacetoacetate (FAA) hydrolase
DF008_RS11285	COG1454	alcohol dehydrogenase
DF008_RS11290	COG1376	ErfK ybiS ycfS ynhG family protein
DF008_RS11300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF008_RS11305	COG0785	Cytochrome C biogenesis protein
DF008_RS11310	COG1733	regulation of RNA biosynthetic process
DF008_RS11315	COG0383	alpha-mannosidase activity
DF008_RS11320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS11335	COG3711	transcriptional antiterminator
DF008_RS11335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS11340	COG4975	Glucose uptake
DF008_RS11375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DF008_RS11385	COG2190	(PTS) system
DF008_RS11390	COG0517	IMP dehydrogenase activity
DF008_RS11390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DF008_RS11395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF008_RS11400	COG1263	PTS System
DF008_RS11400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11405	COG3711	transcriptional antiterminator
DF008_RS11410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DF008_RS11415	COG3118	belongs to the thioredoxin family
DF008_RS11425	COG0384	phenazine biosynthesis protein PhzF
DF008_RS11445	COG0542	response to heat
DF008_RS11470	COG1737	Transcriptional regulator
DF008_RS11475	COG2971	BadF BadG BcrA BcrD
DF008_RS11490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS11510	COG0642	Histidine kinase
DF008_RS11525	COG1136	(ABC) transporter
DF008_RS11535	COG2190	(PTS) system
DF008_RS11550	COG1263	PTS System
DF008_RS11550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11565	COG2115	Belongs to the xylose isomerase family
DF008_RS11570	COG1070	Carbohydrate kinase
DF008_RS11585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS11585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11590	COG3716	PTS system mannose fructose sorbose family IID component
DF008_RS11620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DF008_RS11645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DF008_RS11650	COG0191	fructose-bisphosphate aldolase activity
DF008_RS11655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS11655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11670	COG2723	6-phospho-beta-galactosidase activity
DF008_RS11680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS11690	COG2213	PTS system mannitol-specific
DF008_RS11690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS11695	COG1929	Belongs to the glycerate kinase type-1 family
DF008_RS11700	COG0383	alpha-mannosidase activity
DF008_RS11705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS11705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS11715	COG3394	polysaccharide catabolic process
DF008_RS11720	COG2190	(PTS) system
DF008_RS11720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11720	COG1263	PTS System
DF008_RS11730	COG0366	Alpha amylase catalytic
DF008_RS11740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DF008_RS11755	COG2723	6-phospho-beta-galactosidase activity
DF008_RS11760	COG2723	6-phospho-beta-galactosidase activity
DF008_RS11765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11765	COG2190	(PTS) system
DF008_RS11765	COG1263	PTS System
DF008_RS11770	COG3711	transcriptional antiterminator
DF008_RS11780	COG1288	antiporter activity
DF008_RS11785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11785	COG1263	PTS System
DF008_RS11790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF008_RS11795	COG2190	(PTS) system
DF008_RS11800	COG0561	phosphatase activity
DF008_RS11825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DF008_RS11830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS11830	COG3711	transcriptional antiterminator
DF008_RS11835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF008_RS11840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DF008_RS11845	COG0205	6-phosphofructokinase activity
DF008_RS11855	COG1473	amidohydrolase
DF008_RS11860	COG1473	amidohydrolase
DF008_RS11870	COG2723	6-phospho-beta-galactosidase activity
DF008_RS11875	COG1263	PTS System
DF008_RS11875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11875	COG2190	(PTS) system
DF008_RS11890	COG1819	glycosyl
DF008_RS11895	COG3620	sequence-specific DNA binding
DF008_RS11910	COG0640	Transcriptional regulator
DF008_RS11920	COG2723	6-phospho-beta-galactosidase activity
DF008_RS11925	COG1263	PTS System
DF008_RS11925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11925	COG2190	(PTS) system
DF008_RS11930	COG3711	transcriptional antiterminator
DF008_RS11940	COG0577	efflux transmembrane transporter activity
DF008_RS11940	COG1136	(ABC) transporter
DF008_RS11945	COG1132	(ABC) transporter
DF008_RS11985	COG1475	DNA binding
DF008_RS11990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS11990	COG1263	PTS System
DF008_RS11995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DF008_RS12005	COG2723	6-phospho-beta-galactosidase activity
DF008_RS12015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS12015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS12015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS12020	COG3711	transcriptional antiterminator
DF008_RS12025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS12025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS12025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS12030	COG0191	fructose-bisphosphate aldolase activity
DF008_RS12050	COG0693	protein deglycase activity
DF008_RS12065	COG4509	Sortase family
DF008_RS12090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DF008_RS12155	COG1131	(ABC) transporter
DF008_RS12165	COG0557	exoribonuclease II activity
DF008_RS12180	COG1881	PFAM PEBP family protein
DF008_RS12210	COG0149	triose-phosphate isomerase activity
DF008_RS12225	COG2390	Transcriptional regulator
DF008_RS12230	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DF008_RS12235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DF008_RS12245	COG0167	dihydroorotate dehydrogenase activity
DF008_RS12255	COG0402	S-adenosylhomocysteine deaminase activity
DF008_RS12260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DF008_RS12285	COG0251	oxidation-reduction process
DF008_RS12300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DF008_RS12305	COG0789	Transcriptional regulator
DF008_RS12315	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS12315	COG2247	cell wall binding repeat
DF008_RS12320	COG1136	(ABC) transporter
DF008_RS12325	COG0577	efflux transmembrane transporter activity
DF008_RS12345	COG2207	Transcriptional regulator
DF008_RS12350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DF008_RS12360	COG0789	Transcriptional regulator
DF008_RS12385	COG2205	protein histidine kinase activity
DF008_RS12385	COG2770	Histidine kinase
DF008_RS12390	COG0745	RESPONSE REGULATOR receiver
DF008_RS12395	COG0706	membrane insertase activity
DF008_RS12400	COG0778	Nitroreductase
DF008_RS12410	COG0534	Mate efflux family protein
DF008_RS12435	COG2226	methyltransferase
DF008_RS12455	COG1732	Glycine betaine
DF008_RS12460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DF008_RS12475	COG2226	methyltransferase
DF008_RS12485	COG1473	amidohydrolase
DF008_RS12490	COG1760	l-serine dehydratase
DF008_RS12495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DF008_RS12500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DF008_RS12510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DF008_RS12525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DF008_RS12550	COG2226	methyltransferase
DF008_RS12575	COG0252	asparaginase activity
DF008_RS12575	COG5275	peptidyl-tyrosine sulfation
DF008_RS12580	COG5275	peptidyl-tyrosine sulfation
DF008_RS12580	COG0252	asparaginase activity
DF008_RS12595	COG5275	peptidyl-tyrosine sulfation
DF008_RS12595	COG0252	asparaginase activity
DF008_RS12610	COG4656	Part of a membrane complex involved in electron transport
DF008_RS12620	COG0726	polysaccharide deacetylase
DF008_RS12645	COG0285	dihydrofolate synthase activity
DF008_RS12655	COG3279	Response regulator of the LytR AlgR family
DF008_RS12660	COG0525	valine-tRNA ligase activity
DF008_RS12665	COG0726	polysaccharide deacetylase
DF008_RS12680	COG0704	Plays a role in the regulation of phosphate uptake
DF008_RS12690	COG0581	inorganic phosphate transmembrane transporter activity
DF008_RS12695	COG0573	inorganic phosphate transmembrane transporter activity
DF008_RS12715	COG0745	RESPONSE REGULATOR receiver
DF008_RS12720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DF008_RS12725	COG1164	Oligoendopeptidase f
DF008_RS12730	COG1285	pathogenesis
DF008_RS12755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DF008_RS12760	COG3716	PTS system mannose fructose sorbose family IID component
DF008_RS12765	COG3715	PTS system
DF008_RS12770	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS12770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS12775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS12775	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS12785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DF008_RS12800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DF008_RS12810	COG1283	sodium-dependent phosphate transmembrane transporter activity
DF008_RS12815	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DF008_RS12830	COG1405	negative regulation of cell septum assembly
DF008_RS12830	COG3012	SEC-C Motif Domain Protein
DF008_RS12855	COG1459	type II secretion system
DF008_RS12895	COG2059	Chromate
DF008_RS12905	COG0740	serine-type endopeptidase activity
DF008_RS12945	COG0493	'glutamate synthase
DF008_RS12945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DF008_RS12955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DF008_RS12965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DF008_RS13015	COG0457	Tetratricopeptide repeat
DF008_RS13015	COG0463	Glycosyl transferase, family 2
DF008_RS13030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS13040	COG0778	Nitroreductase
DF008_RS13045	COG1733	regulation of RNA biosynthetic process
DF008_RS13050	COG0693	protein deglycase activity
DF008_RS13055	COG1522	sequence-specific DNA binding
DF008_RS13060	COG0488	(ABC) transporter
DF008_RS13065	COG0745	RESPONSE REGULATOR receiver
DF008_RS13085	COG4555	ABC transporter
DF008_RS13090	COG5001	Diguanylate cyclase
DF008_RS13175	COG2116	formate transmembrane transporter activity
DF008_RS13180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DF008_RS13220	COG0556	nucleotide-excision repair
DF008_RS13230	COG1653	transport
DF008_RS13240	COG1175	transmembrane transport
DF008_RS13245	COG3842	ATPase activity
DF008_RS13265	COG1648	precorrin-2 dehydrogenase activity
DF008_RS13265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DF008_RS13270	COG0113	porphobilinogen synthase activity
DF008_RS13290	COG2099	Precorrin-6x reductase
DF008_RS13305	COG2875	Belongs to the precorrin methyltransferase family
DF008_RS13315	COG2241	protein methyltransferase activity
DF008_RS13335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DF008_RS13345	COG1797	cobyrinic acid a,c-diamide synthase activity
DF008_RS13355	COG0406	alpha-ribazole phosphatase activity
DF008_RS13365	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
DF008_RS13390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF008_RS13405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS13410	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF008_RS13415	COG1363	Peptidase, m42
DF008_RS13420	COG3711	transcriptional antiterminator
DF008_RS13425	COG0191	fructose-bisphosphate aldolase activity
DF008_RS13430	COG2222	sugar isomerase
DF008_RS13465	COG0793	Belongs to the peptidase S41A family
DF008_RS13465	COG3409	Peptidoglycan-binding domain 1 protein
DF008_RS13470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DF008_RS13480	COG3949	Membrane
DF008_RS13485	COG3958	Transketolase
DF008_RS13490	COG3959	Transketolase, thiamine diphosphate binding domain
DF008_RS13495	COG2337	Toxic component of a toxin-antitoxin (TA) module
DF008_RS13515	COG0517	IMP dehydrogenase activity
DF008_RS13515	COG0516	GMP reductase activity
DF008_RS13520	COG0736	holo-[acyl-carrier-protein] synthase activity
DF008_RS13525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DF008_RS13535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DF008_RS13580	COG3608	succinylglutamate desuccinylase aspartoacylase
DF008_RS13580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DF008_RS13590	COG0698	ribose 5-phosphate isomerase
DF008_RS13600	COG0009	L-threonylcarbamoyladenylate synthase
DF008_RS13615	COG2890	protein-(glutamine-N5) methyltransferase activity
DF008_RS13620	COG3872	metal-dependent enzyme
DF008_RS13630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DF008_RS13635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DF008_RS13645	COG2208	phosphoserine phosphatase activity
DF008_RS13650	COG0248	Ppx GppA phosphatase
DF008_RS13670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DF008_RS13680	COG3956	TIGRFAM MazG family protein
DF008_RS13685	COG2244	polysaccharide biosynthetic process
DF008_RS13690	COG2002	toxin-antitoxin pair type II binding
DF008_RS13695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DF008_RS13700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DF008_RS13780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DF008_RS13795	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DF008_RS13800	COG2195	Cleaves the N-terminal amino acid of tripeptides
DF008_RS13815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DF008_RS13820	COG1840	ABC-type Fe3 transport system, periplasmic component
DF008_RS13830	COG3842	ATPase activity
DF008_RS13835	COG1840	ABC-type Fe3 transport system, periplasmic component
DF008_RS13845	COG3842	ATPase activity
DF008_RS13850	COG0613	PHP domain protein
DF008_RS13855	COG3454	Phosphonate metabolism
DF008_RS13860	COG4778	phosphonate C-P lyase system protein PhnL
DF008_RS13865	COG4107	phosphonate C-P lyase system protein PhnK
DF008_RS13870	COG3627	carbon phosphorus lyase activity
DF008_RS13890	COG0084	hydrolase, TatD family'
DF008_RS13895	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF008_RS13895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF008_RS13900	COG0700	Nucleoside recognition
DF008_RS13910	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DF008_RS13915	COG1522	sequence-specific DNA binding
DF008_RS13925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DF008_RS13930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DF008_RS13935	COG1774	PSP1 C-terminal conserved region
DF008_RS13940	COG0470	DNA polymerase III
DF008_RS13945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DF008_RS13950	COG1982	Orn Lys Arg decarboxylase major
DF008_RS13955	COG2155	Conserved Protein
DF008_RS13980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DF008_RS14005	COG3191	aminopeptidase activity
DF008_RS14015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DF008_RS14030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DF008_RS14035	COG3409	Peptidoglycan-binding domain 1 protein
DF008_RS14035	COG3773	Cell wall hydrolase
DF008_RS14045	COG1802	Transcriptional regulator
DF008_RS14080	COG0653	protein targeting
DF008_RS14105	COG2271	Major facilitator Superfamily
DF008_RS14110	COG0626	cystathionine gamma-synthase activity
DF008_RS14135	COG0564	pseudouridine synthase activity
DF008_RS14140	COG4978	Transcriptional regulator
DF008_RS14140	COG0789	Transcriptional regulator
DF008_RS14150	COG1136	(ABC) transporter
DF008_RS14150	COG0577	efflux transmembrane transporter activity
DF008_RS14175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DF008_RS14185	COG0284	orotidine-5'-phosphate decarboxylase activity
DF008_RS14205	COG1410	methionine synthase
DF008_RS14205	COG0646	methionine synthase
DF008_RS14230	COG1876	peptidase activity
DF008_RS14235	COG0037	tRNA processing
DF008_RS14240	COG1408	metallophosphoesterase
DF008_RS14255	COG1141	Ferredoxin
DF008_RS14260	COG3964	amidohydrolase
DF008_RS14270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DF008_RS14280	COG0346	lactoylglutathione lyase activity
DF008_RS14285	COG0534	Mate efflux family protein
DF008_RS14300	COG0789	Transcriptional regulator
DF008_RS14300	COG4978	Transcriptional regulator
DF008_RS14310	COG5504	Zn-dependent protease
DF008_RS14320	COG0519	Catalyzes the synthesis of GMP from XMP
DF008_RS14330	COG1357	PFAM Pentapeptide repeats (8 copies)
DF008_RS14335	COG2824	Alkylphosphonate utilization operon protein PhnA
DF008_RS14340	COG0577	efflux transmembrane transporter activity
DF008_RS14340	COG1136	(ABC) transporter
DF008_RS14350	COG5002	protein histidine kinase activity
DF008_RS14350	COG5001	Diguanylate cyclase
DF008_RS14350	COG3447	MASE1 domain protein
DF008_RS14360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DF008_RS14365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DF008_RS14365	COG0517	IMP dehydrogenase activity
DF008_RS14385	COG1335	isochorismatase
DF008_RS14395	COG0789	Transcriptional regulator
DF008_RS14425	COG0583	DNA-binding transcription factor activity
DF008_RS14430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DF008_RS14430	COG1522	sequence-specific DNA binding
DF008_RS14445	COG3964	amidohydrolase
DF008_RS14455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS14460	COG2188	Transcriptional regulator
DF008_RS14465	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF008_RS14470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS14480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS14485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DF008_RS14500	COG1484	DNA-dependent DNA replication
DF008_RS14535	COG0305	Participates in initiation and elongation during chromosome replication
DF008_RS14545	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DF008_RS14565	COG0629	single-stranded DNA binding
DF008_RS14575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF008_RS14590	COG0425	Belongs to the sulfur carrier protein TusA family
DF008_RS14605	COG1104	cysteine desulfurase activity
DF008_RS14610	COG1475	DNA binding
DF008_RS14615	COG1192	Involved in chromosome partitioning
DF008_RS14625	COG0357	Ribosomal RNA small subunit methyltransferase G
DF008_RS14640	COG1847	R3H domain protein
DF008_RS14645	COG0706	membrane insertase activity
DF008_RS14650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DF008_RS14660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DF008_RS14665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DF008_RS14670	COG0592	DNA-directed DNA polymerase activity
DF008_RS14685	COG0187	DNA topoisomerase II activity
DF008_RS14690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DF008_RS14705	COG1366	Belongs to the anti-sigma-factor antagonist family
DF008_RS14715	COG1191	sigma factor activity
DF008_RS14765	COG1827	regulation of RNA biosynthetic process
DF008_RS14770	COG0668	transmembrane transport
DF008_RS14775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DF008_RS14780	COG0590	tRNA wobble adenosine to inosine editing
DF008_RS14795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DF008_RS14815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DF008_RS15055	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DF008_RS15060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DF008_RS15065	COG4463	regulation of RNA biosynthetic process
DF008_RS15070	COG3880	PFAM UvrB UvrC protein
DF008_RS15075	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DF008_RS15080	COG0542	response to heat
DF008_RS15085	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DF008_RS15095	COG4956	integral membrane protein (PIN domain superfamily)
DF008_RS15115	COG3507	Belongs to the glycosyl hydrolase 43 family
DF008_RS15125	COG2390	Transcriptional regulator
DF008_RS15130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DF008_RS15135	COG0022	dehydrogenase e1 component
DF008_RS15140	COG0508	dehydrogenase complex catalyzes the overall conversion of
DF008_RS15145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF008_RS15150	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF008_RS15150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF008_RS15160	COG3414	Phosphotransferase system galactitol-specific IIB component
DF008_RS15165	COG3775	system Galactitol-specific IIC component
DF008_RS15180	COG0095	Lipoate-protein ligase
DF008_RS15230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DF008_RS15235	COG3688	RNA-binding protein containing a PIN domain
DF008_RS15260	COG0250	Participates in transcription elongation, termination and antitermination
DF008_RS15285	COG1028	Short-chain dehydrogenase reductase Sdr
DF008_RS15330	COG0088	Forms part of the polypeptide exit tunnel
DF008_RS15385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DF008_RS15435	COG0024	Methionine aminopeptidase
DF008_RS15450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DF008_RS15490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DF008_RS15510	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF008_RS15755	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DF008_RS15770	COG0280	phosphate acetyltransferase
DF008_RS15810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DF008_RS15815	COG2897	thiosulfate sulfurtransferase activity
DF008_RS15825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DF008_RS15830	COG2385	sporulation resulting in formation of a cellular spore
DF008_RS15840	COG1609	Transcriptional regulator
DF008_RS15845	COG1077	Cell shape determining protein MreB Mrl
DF008_RS15865	COG3949	Membrane
DF008_RS15870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DF008_RS15875	COG1040	competence protein
DF008_RS15880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS15880	COG3711	transcriptional antiterminator
DF008_RS15885	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF008_RS15890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS15895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF008_RS15905	COG1446	asparaginase
DF008_RS15910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF008_RS15915	COG3142	Participates in the control of copper homeostasis
DF008_RS15920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DF008_RS15930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DF008_RS15935	COG2183	response to ionizing radiation
DF008_RS15940	COG1228	amidohydrolase
DF008_RS15955	COG0802	atpase or kinase
DF008_RS15960	COG1214	PFAM Peptidase M22, glycoprotease
DF008_RS15965	COG0456	acetyltransferase
DF008_RS16005	COG1136	(ABC) transporter
DF008_RS16020	COG1473	amidohydrolase
DF008_RS16035	COG0534	Mate efflux family protein
DF008_RS16040	COG0488	(ABC) transporter
DF008_RS16055	COG2221	Nitrite and sulphite reductase 4Fe-4S
DF008_RS16065	COG1151	hydroxylamine reductase activity
DF008_RS16080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DF008_RS16095	COG2602	Beta-lactamase
DF008_RS16095	COG4219	Peptidase M56
DF008_RS16120	COG0543	2 iron, 2 sulfur cluster binding
DF008_RS16140	COG0583	DNA-binding transcription factor activity
DF008_RS16170	COG1691	(AIR) carboxylase
DF008_RS16175	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DF008_RS16180	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DF008_RS16215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DF008_RS16220	COG2200	EAL domain
DF008_RS16220	COG2771	luxR family
DF008_RS16235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS16240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS16255	COG1213	nucleotidyl transferase
DF008_RS16275	COG1943	Transposase
DF008_RS16285	COG0778	Nitroreductase
DF008_RS16290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DF008_RS16295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DF008_RS16300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DF008_RS16310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DF008_RS16320	COG0151	Belongs to the GarS family
DF008_RS16325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DF008_RS16330	COG0741	lytic transglycosylase activity
DF008_RS16385	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DF008_RS16395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DF008_RS16400	COG0463	Glycosyl transferase, family 2
DF008_RS16405	COG0560	Phosphoserine phosphatase
DF008_RS16410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DF008_RS16425	COG4786	Flagellar basal body rod
DF008_RS16435	COG1677	Flagellar hook-basal body complex protein FliE
DF008_RS16440	COG1766	The M ring may be actively involved in energy transduction
DF008_RS16445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DF008_RS16455	COG1157	protein secretion by the type III secretion system
DF008_RS16470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DF008_RS16475	COG4786	Flagellar basal body rod
DF008_RS16485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DF008_RS16490	COG1360	Flagellar Motor Protein
DF008_RS16505	COG1338	Plays a role in the flagellum-specific transport system
DF008_RS16515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DF008_RS16520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DF008_RS16525	COG1419	protein localization to endoplasmic reticulum
DF008_RS16530	COG0455	bacterial-type flagellum organization
DF008_RS16535	COG1191	sigma factor activity
DF008_RS16550	COG4786	Flagellar basal body rod
DF008_RS16565	COG1776	CheC inhibitor of MCP methylation
DF008_RS16565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DF008_RS16580	COG1454	alcohol dehydrogenase
DF008_RS16585	COG1533	DNA photolyase activity
DF008_RS16600	COG1733	regulation of RNA biosynthetic process
DF008_RS16620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DF008_RS16625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF008_RS16625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF008_RS16630	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF008_RS16630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF008_RS16655	COG3716	PTS system mannose fructose sorbose family IID component
DF008_RS16665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF008_RS16675	COG3620	sequence-specific DNA binding
DF008_RS16685	COG1131	(ABC) transporter
DF008_RS16715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DF008_RS16720	COG1879	ABC-type sugar transport system periplasmic component
DF008_RS16725	COG1129	ABC transporter
DF008_RS16730	COG1172	Belongs to the binding-protein-dependent transport system permease family
DF008_RS16735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF008_RS16745	COG1473	amidohydrolase
DF008_RS16785	COG2217	Heavy metal translocating P-type atpase
DF008_RS16805	COG0586	Pfam SNARE associated Golgi protein
DF008_RS16830	COG2205	protein histidine kinase activity
DF008_RS16835	COG0745	RESPONSE REGULATOR receiver
DF008_RS16860	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
DF008_RS16870	COG1122	ATPase activity
DF008_RS16875	COG0210	DNA helicase
DF008_RS16880	COG1362	aminopeptidase activity
DF008_RS16890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DF008_RS16905	COG1454	alcohol dehydrogenase
DF008_RS16905	COG1012	belongs to the aldehyde dehydrogenase family
DF008_RS16915	COG1136	(ABC) transporter
DF008_RS16925	COG3290	protein histidine kinase activity
DF008_RS16955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF008_RS16960	COG2357	RelA SpoT domain protein
DF008_RS16980	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DF008_RS17005	COG1263	PTS System
DF008_RS17005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS17005	COG2190	(PTS) system
DF008_RS17010	COG2723	6-phospho-beta-galactosidase activity
DF008_RS17015	COG3711	transcriptional antiterminator
DF008_RS17025	COG0367	asparagine synthase
DF008_RS17040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DF008_RS17065	COG1960	acyl-CoA dehydrogenase activity
DF008_RS17070	COG2086	electron transfer activity
DF008_RS17075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DF008_RS17085	COG0191	fructose-bisphosphate aldolase activity
DF008_RS17145	COG3829	transcription factor binding
DF008_RS17150	COG3804	dihydrodipicolinate reductase
DF008_RS17160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DF008_RS17170	COG5012	cobalamin binding
DF008_RS17180	COG3457	Alanine racemase
DF008_RS17185	COG1757	Na H antiporter
DF008_RS17220	COG3973	AAA domain
DF008_RS17230	COG1136	(ABC) transporter
DF008_RS17240	COG5002	protein histidine kinase activity
DF008_RS17245	COG0745	RESPONSE REGULATOR receiver
DF008_RS17250	COG1309	transcriptional regulator
DF008_RS17260	COG1737	Transcriptional regulator
DF008_RS17270	COG0561	phosphatase activity
DF008_RS17280	COG1263	PTS System
DF008_RS17280	COG2190	(PTS) system
DF008_RS17280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS17345	COG5002	protein histidine kinase activity
DF008_RS17350	COG0577	efflux transmembrane transporter activity
DF008_RS17350	COG1136	(ABC) transporter
DF008_RS17355	COG1136	(ABC) transporter
DF008_RS17360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DF008_RS17370	COG0745	RESPONSE REGULATOR receiver
DF008_RS17375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DF008_RS17380	COG2076	Multidrug Resistance protein
DF008_RS17390	COG1063	alcohol dehydrogenase
DF008_RS17400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF008_RS17410	COG3716	PTS system mannose fructose sorbose family IID component
DF008_RS17430	COG1686	Belongs to the peptidase S11 family
DF008_RS17435	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF008_RS17435	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF008_RS17455	COG2205	protein histidine kinase activity
DF008_RS17480	COG2195	Cleaves the N-terminal amino acid of tripeptides
DF008_RS17485	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DF008_RS17510	COG2378	regulation of single-species biofilm formation
DF008_RS17520	COG2201	protein-glutamate methylesterase activity
DF008_RS17525	COG1776	CheC inhibitor of MCP methylation
DF008_RS17530	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DF008_RS17535	COG0835	chemotaxis
DF008_RS17540	COG0745	RESPONSE REGULATOR receiver
DF008_RS17540	COG3706	GGDEF domain
DF008_RS17545	COG0840	transmembrane signaling receptor activity
DF008_RS17550	COG0643	Histidine kinase
DF008_RS17550	COG2198	Histidine kinase
DF008_RS17555	COG0835	chemotaxis
DF008_RS17565	COG2201	protein-glutamate methylesterase activity
DF008_RS17620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DF008_RS17620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DF008_RS17625	COG0681	Belongs to the peptidase S26 family
DF008_RS17640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DF008_RS17670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DF008_RS17675	COG1067	ATP-dependent peptidase activity
DF008_RS17680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DF008_RS17685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DF008_RS17715	COG4399	Belongs to the UPF0754 family
DF008_RS17755	COG1309	transcriptional regulator
DF008_RS17760	COG0574	Belongs to the PEP-utilizing enzyme family
DF008_RS17760	COG3848	Pyruvate phosphate dikinase
DF008_RS17775	COG3706	GGDEF domain
DF008_RS17835	COG3969	phosphoadenosine phosphosulfate
DF008_RS17840	COG1475	DNA binding
DF008_RS17855	COG3546	catalase activity
DF008_RS17865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DF008_RS17925	COG3279	Response regulator of the LytR AlgR family
DF008_RS17930	COG0577	efflux transmembrane transporter activity
DF008_RS17935	COG1136	(ABC) transporter
DF008_RS17950	COG4978	Transcriptional regulator
DF008_RS17950	COG0789	Transcriptional regulator
DF008_RS17995	COG0305	Participates in initiation and elongation during chromosome replication
DF008_RS18015	COG1132	(ABC) transporter
DF008_RS18020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DF008_RS18025	COG0534	Mate efflux family protein
DF008_RS18040	COG4335	DNA alkylation repair
DF008_RS18095	COG0745	RESPONSE REGULATOR receiver
DF008_RS18100	COG2205	protein histidine kinase activity
DF008_RS18105	COG1131	(ABC) transporter
DF008_RS18120	COG1802	Transcriptional regulator
DF008_RS18125	COG0823	Involved in the tonB-independent uptake of proteins
DF008_RS18125	COG1506	peptidase
DF008_RS18125	COG4946	Tricorn protease homolog
DF008_RS18130	COG4946	Tricorn protease homolog
DF008_RS18130	COG1506	peptidase
DF008_RS18130	COG0823	Involved in the tonB-independent uptake of proteins
DF008_RS18140	COG1737	Transcriptional regulator
DF008_RS18145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF008_RS18145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS18145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF008_RS18150	COG0383	alpha-mannosidase activity
DF008_RS18195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DF008_RS18205	COG1136	(ABC) transporter
DF008_RS18210	COG1132	(ABC) transporter
DF008_RS18215	COG2801	Transposase and inactivated derivatives
DF008_RS18230	COG0038	chloride channel
DF008_RS18275	COG5002	protein histidine kinase activity
DF008_RS18310	COG1595	DNA-templated transcription, initiation
DF008_RS18325	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DF008_RS18345	COG2814	Major facilitator Superfamily
DF008_RS18350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DF008_RS18355	COG1609	Transcriptional regulator
DF008_RS18410	COG0789	Transcriptional regulator
DF008_RS18430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DF008_RS18435	COG0569	domain protein
DF008_RS18440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DF008_RS18445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DF008_RS18450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF008_RS18450	COG0072	phenylalanine-tRNA ligase activity
DF008_RS18465	COG0826	peptidase U32
DF008_RS18475	COG1051	belongs to the nudix hydrolase family
DF008_RS18485	COG3706	GGDEF domain
DF008_RS18490	COG2195	Cleaves the N-terminal amino acid of tripeptides
DF008_RS18500	COG1683	Conserved Protein