locus-tag	class	description
JMW49_RS00015	COG1288	antiporter activity
JMW49_RS00030	COG2022	thiamine diphosphate biosynthetic process
JMW49_RS00045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JMW49_RS00050	COG0514	ATP-dependent DNA helicase (RecQ)
JMW49_RS00065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JMW49_RS00065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JMW49_RS00080	COG1115	amino acid carrier protein
JMW49_RS00110	COG3118	belongs to the thioredoxin family
JMW49_RS00115	COG5002	protein histidine kinase activity
JMW49_RS00120	COG0745	RESPONSE REGULATOR receiver
JMW49_RS00155	COG1309	transcriptional regulator
JMW49_RS00180	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JMW49_RS00185	COG1733	regulation of RNA biosynthetic process
JMW49_RS00200	COG2205	protein histidine kinase activity
JMW49_RS00205	COG0745	RESPONSE REGULATOR receiver
JMW49_RS00215	COG1131	(ABC) transporter
JMW49_RS00230	COG0584	glycerophosphoryl diester phosphodiesterase
JMW49_RS00240	COG1396	sequence-specific DNA binding
JMW49_RS00270	COG3123	guanosine phosphorylase activity
JMW49_RS00275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JMW49_RS00280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JMW49_RS00285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JMW49_RS00295	COG1757	Na H antiporter
JMW49_RS00300	COG0095	Lipoate-protein ligase
JMW49_RS00315	COG5001	Diguanylate cyclase
JMW49_RS00315	COG3706	GGDEF domain
JMW49_RS00315	COG4251	negative regulation of phosphorylation
JMW49_RS00315	COG2203	Gaf domain
JMW49_RS00320	COG4607	ABC-type enterochelin transport system periplasmic component
JMW49_RS00325	COG4604	ABC transporter, ATP-binding protein
JMW49_RS00330	COG4605	iron ion homeostasis
JMW49_RS00335	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JMW49_RS00345	COG5505	Protein of unknown function (DUF819)
JMW49_RS00375	COG3853	Toxic anion resistance protein (TelA)
JMW49_RS00390	COG2310	stress, protein
JMW49_RS00405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JMW49_RS00410	COG0367	asparagine synthase
JMW49_RS00430	COG0426	domain, Protein
JMW49_RS00440	COG0668	transmembrane transport
JMW49_RS00455	COG1131	(ABC) transporter
JMW49_RS00460	COG1725	Transcriptional regulator
JMW49_RS00465	COG5001	Diguanylate cyclase
JMW49_RS00465	COG3300	MHYT domain
JMW49_RS00470	COG1668	transmembrane transport
JMW49_RS00475	COG4555	ABC transporter
JMW49_RS00485	COG0402	S-adenosylhomocysteine deaminase activity
JMW49_RS00510	COG1131	(ABC) transporter
JMW49_RS00515	COG1725	Transcriptional regulator
JMW49_RS00535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS00540	COG0352	thiamine-phosphate diphosphorylase activity
JMW49_RS00545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JMW49_RS00550	COG0351	phosphomethylpyrimidine kinase
JMW49_RS00565	COG0024	Methionine aminopeptidase
JMW49_RS00575	COG1045	serine acetyltransferase
JMW49_RS00580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JMW49_RS00585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JMW49_RS00590	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JMW49_RS00595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JMW49_RS00605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JMW49_RS00625	COG0596	Alpha beta hydrolase
JMW49_RS00630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JMW49_RS00640	COG0460	homoserine dehydrogenase
JMW49_RS00645	COG5002	protein histidine kinase activity
JMW49_RS00650	COG1295	ribonuclease BN
JMW49_RS00655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JMW49_RS00665	COG1388	LysM domain
JMW49_RS00665	COG3584	3D domain protein
JMW49_RS00685	COG1136	(ABC) transporter
JMW49_RS00690	COG2267	carboxylic ester hydrolase activity
JMW49_RS00700	COG1331	Highly conserved protein containing a thioredoxin domain
JMW49_RS00705	COG3546	catalase activity
JMW49_RS00710	COG0028	Belongs to the TPP enzyme family
JMW49_RS00715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JMW49_RS00730	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JMW49_RS00745	COG1595	DNA-templated transcription, initiation
JMW49_RS00760	COG0531	amino acid
JMW49_RS00765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JMW49_RS00765	COG0140	phosphoribosyl-ATP diphosphatase activity
JMW49_RS00770	COG0107	imidazoleglycerol-phosphate synthase activity
JMW49_RS00775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JMW49_RS00780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JMW49_RS00785	COG0131	Imidazoleglycerol-phosphate dehydratase
JMW49_RS00790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMW49_RS00795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JMW49_RS00800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JMW49_RS00840	COG0577	efflux transmembrane transporter activity
JMW49_RS00845	COG1136	(ABC) transporter
JMW49_RS00855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JMW49_RS00855	COG0493	'glutamate synthase
JMW49_RS00870	COG0405	Gamma-glutamyltransferase
JMW49_RS00875	COG0577	efflux transmembrane transporter activity
JMW49_RS00880	COG1136	(ABC) transporter
JMW49_RS00885	COG0745	RESPONSE REGULATOR receiver
JMW49_RS00890	COG2205	protein histidine kinase activity
JMW49_RS00900	COG0577	efflux transmembrane transporter activity
JMW49_RS00900	COG1136	(ABC) transporter
JMW49_RS00905	COG0577	efflux transmembrane transporter activity
JMW49_RS00910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JMW49_RS00915	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
JMW49_RS00920	COG1773	rubredoxin
JMW49_RS00920	COG1592	Rubrerythrin
JMW49_RS00930	COG0726	polysaccharide deacetylase
JMW49_RS00935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JMW49_RS00955	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JMW49_RS00960	COG4978	Transcriptional regulator
JMW49_RS00960	COG0789	Transcriptional regulator
JMW49_RS00965	COG5001	Diguanylate cyclase
JMW49_RS00975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JMW49_RS00980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JMW49_RS01005	COG3901	Regulator of nitric oxide reductase transcription
JMW49_RS01005	COG0348	domain, Protein
JMW49_RS01015	COG0534	Mate efflux family protein
JMW49_RS01025	COG1131	(ABC) transporter
JMW49_RS01035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JMW49_RS01050	COG0701	Predicted permease
JMW49_RS01055	COG0523	cobalamin synthesis protein
JMW49_RS01060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JMW49_RS01065	COG1121	(ABC) transporter
JMW49_RS01070	COG0803	Belongs to the bacterial solute-binding protein 9 family
JMW49_RS01090	COG4086	secreted protein
JMW49_RS01095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JMW49_RS01100	COG1396	sequence-specific DNA binding
JMW49_RS01105	COG2094	Belongs to the DNA glycosylase MPG family
JMW49_RS01110	COG5002	protein histidine kinase activity
JMW49_RS01115	COG1464	Belongs to the NlpA lipoprotein family
JMW49_RS01120	COG2011	ABC-type metal ion transport system permease component
JMW49_RS01125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JMW49_RS01160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JMW49_RS01195	COG0412	Dienelactone hydrolase
JMW49_RS01200	COG1592	Rubrerythrin
JMW49_RS01200	COG1773	rubredoxin
JMW49_RS01205	COG1132	(ABC) transporter
JMW49_RS01210	COG1132	(ABC) transporter
JMW49_RS01240	COG1136	(ABC) transporter
JMW49_RS01240	COG0577	efflux transmembrane transporter activity
JMW49_RS01245	COG3850	Histidine kinase
JMW49_RS01245	COG5002	protein histidine kinase activity
JMW49_RS01250	COG0745	RESPONSE REGULATOR receiver
JMW49_RS01260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS01280	COG0655	NAD(P)H dehydrogenase (quinone) activity
JMW49_RS01285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JMW49_RS01290	COG2384	SAM-dependent methyltransferase
JMW49_RS01295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JMW49_RS01300	COG0358	DNA primase activity
JMW49_RS01305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JMW49_RS01310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JMW49_RS01315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JMW49_RS01320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JMW49_RS01325	COG0302	gtp cyclohydrolase
JMW49_RS01335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JMW49_RS01340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JMW49_RS01345	COG0512	Glutamine amidotransferase of anthranilate synthase
JMW49_RS01350	COG0726	polysaccharide deacetylase
JMW49_RS01355	COG2340	Cysteine-rich secretory protein family
JMW49_RS01365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JMW49_RS01370	COG1346	cytolysis
JMW49_RS01385	COG3829	transcription factor binding
JMW49_RS01390	COG2720	vancomycin resistance protein
JMW49_RS01405	COG0450	alkyl hydroperoxide reductase
JMW49_RS01420	COG0726	polysaccharide deacetylase
JMW49_RS01430	COG1285	pathogenesis
JMW49_RS01440	COG4978	Transcriptional regulator
JMW49_RS01440	COG0789	Transcriptional regulator
JMW49_RS01450	COG2199	diguanylate cyclase activity
JMW49_RS01450	COG2203	Gaf domain
JMW49_RS01455	COG5001	Diguanylate cyclase
JMW49_RS01455	COG3447	MASE1 domain protein
JMW49_RS01455	COG5002	protein histidine kinase activity
JMW49_RS01460	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JMW49_RS01485	COG1242	4 iron, 4 sulfur cluster binding
JMW49_RS01495	COG3829	transcription factor binding
JMW49_RS01510	COG1058	Belongs to the CinA family
JMW49_RS01510	COG1546	Belongs to the CinA family
JMW49_RS01515	COG1181	Belongs to the D-alanine--D-alanine ligase family
JMW49_RS01520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS01560	COG0584	glycerophosphoryl diester phosphodiesterase
JMW49_RS01575	COG1619	proteins homologs of microcin C7 resistance protein MccF
JMW49_RS01580	COG1473	amidohydrolase
JMW49_RS01625	COG4948	Mandelate Racemase Muconate Lactonizing
JMW49_RS01630	COG1396	sequence-specific DNA binding
JMW49_RS01635	COG1984	allophanate hydrolase subunit 2
JMW49_RS01640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JMW49_RS01645	COG1914	H( )-stimulated, divalent metal cation uptake system
JMW49_RS01650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JMW49_RS01655	COG0471	metal ion transport
JMW49_RS01655	COG3273	potassium ion transport
JMW49_RS01660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JMW49_RS01670	COG2814	Major facilitator Superfamily
JMW49_RS01675	COG1396	sequence-specific DNA binding
JMW49_RS01690	COG1396	sequence-specific DNA binding
JMW49_RS01720	COG3778	Protein conserved in bacteria
JMW49_RS01725	COG3299	homolog of phage Mu protein gp47
JMW49_RS01795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JMW49_RS01805	COG1278	Cold shock
JMW49_RS01835	COG1131	(ABC) transporter
JMW49_RS01860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JMW49_RS01875	COG0708	Exodeoxyribonuclease III
JMW49_RS01885	COG0436	Aminotransferase
JMW49_RS01895	COG0114	fumarate hydratase activity
JMW49_RS01905	COG1968	undecaprenyl-diphosphatase activity
JMW49_RS01930	COG5001	Diguanylate cyclase
JMW49_RS01935	COG1418	mRNA catabolic process
JMW49_RS01940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JMW49_RS01950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JMW49_RS01955	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JMW49_RS01965	COG0740	serine-type endopeptidase activity
JMW49_RS01970	COG0527	aspartate kinase activity
JMW49_RS01975	COG1873	PFAM PRC-barrel domain
JMW49_RS01980	COG0612	Peptidase, M16
JMW49_RS01985	COG0726	polysaccharide deacetylase
JMW49_RS01990	COG1185	polyribonucleotide nucleotidyltransferase activity
JMW49_RS01995	COG1307	EDD domain protein, DegV family
JMW49_RS02000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JMW49_RS02005	COG0196	riboflavin kinase activity
JMW49_RS02010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JMW49_RS02015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JMW49_RS02025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JMW49_RS02035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JMW49_RS02040	COG0195	Participates in both transcription termination and antitermination
JMW49_RS02045	COG0779	Required for maturation of 30S ribosomal subunits
JMW49_RS02100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JMW49_RS02110	COG1994	Peptidase M50
JMW49_RS02115	COG1917	Cupin 2, conserved barrel domain protein
JMW49_RS02115	COG2207	Transcriptional regulator
JMW49_RS02125	COG1686	Belongs to the peptidase S11 family
JMW49_RS02135	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JMW49_RS02145	COG0735	belongs to the Fur family
JMW49_RS02150	COG3906	Belongs to the UPF0473 family
JMW49_RS02155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JMW49_RS02165	COG4472	Bacterial protein of unknown function (DUF965)
JMW49_RS02170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JMW49_RS02175	COG0482	sulfurtransferase activity
JMW49_RS02180	COG0822	iron-sulfur transferase activity
JMW49_RS02190	COG1959	2 iron, 2 sulfur cluster binding
JMW49_RS02200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JMW49_RS02210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JMW49_RS02215	COG0758	DNA mediated transformation
JMW49_RS02220	COG0606	chelatase, subunit chli
JMW49_RS02225	COG0792	nuclease activity
JMW49_RS02230	COG4585	Histidine kinase
JMW49_RS02235	COG2197	response regulator
JMW49_RS02240	COG1131	(ABC) transporter
JMW49_RS02270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JMW49_RS02285	COG1114	Component of the transport system for branched-chain amino acids
JMW49_RS02295	COG0335	large ribosomal subunit rRNA binding
JMW49_RS02300	COG0336	Belongs to the RNA methyltransferase TrmD family
JMW49_RS02305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JMW49_RS02315	COG0228	four-way junction DNA binding
JMW49_RS02320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JMW49_RS02330	COG0552	protein localization to endoplasmic reticulum
JMW49_RS02335	COG1196	nuclear chromosome segregation
JMW49_RS02345	COG0571	ribonuclease III activity
JMW49_RS02355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JMW49_RS02450	COG0768	penicillin binding
JMW49_RS02455	COG0826	peptidase U32
JMW49_RS02460	COG4122	O-methyltransferase activity
JMW49_RS02465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JMW49_RS02480	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JMW49_RS02485	COG4974	Belongs to the 'phage' integrase family
JMW49_RS02495	COG0494	nUDIX hydrolase
JMW49_RS02530	COG0750	zinc metalloprotease
JMW49_RS02535	COG0456	acetyltransferase
JMW49_RS02540	COG0456	acetyltransferase
JMW49_RS02550	COG0497	DNA recombination
JMW49_RS02555	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JMW49_RS02560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JMW49_RS02565	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
JMW49_RS02575	COG1722	exodeoxyribonuclease VII activity
JMW49_RS02580	COG1570	exodeoxyribonuclease VII activity
JMW49_RS02585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JMW49_RS02590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JMW49_RS02595	COG1302	Protein conserved in bacteria
JMW49_RS02635	COG3854	ATPases associated with a variety of cellular activities
JMW49_RS02640	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JMW49_RS02655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JMW49_RS02670	COG3706	GGDEF domain
JMW49_RS02675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JMW49_RS02680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JMW49_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
JMW49_RS02690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JMW49_RS02700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JMW49_RS02705	COG0416	fatty acid biosynthetic process
JMW49_RS02715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JMW49_RS02725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JMW49_RS02730	COG1323	Belongs to the UPF0348 family
JMW49_RS02735	COG0277	FAD linked oxidase domain protein
JMW49_RS02740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JMW49_RS02745	COG2086	electron transfer activity
JMW49_RS02750	COG3875	lactate racemase activity
JMW49_RS02755	COG2186	Transcriptional regulator
JMW49_RS02760	COG3314	Sporulation integral membrane protein YlbJ
JMW49_RS02770	COG0460	homoserine dehydrogenase
JMW49_RS02780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JMW49_RS02785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JMW49_RS02795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JMW49_RS02800	COG1530	ribonuclease E activity
JMW49_RS02815	COG0426	domain, Protein
JMW49_RS02830	COG1695	Transcriptional regulator
JMW49_RS02835	COG1803	Methylglyoxal synthase
JMW49_RS02840	COG0772	Belongs to the SEDS family
JMW49_RS02845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JMW49_RS02850	COG2894	cell division
JMW49_RS02855	COG0850	regulation of cytokinetic process
JMW49_RS02875	COG1077	Cell shape determining protein MreB Mrl
JMW49_RS02880	COG2003	Belongs to the UPF0758 family
JMW49_RS02885	COG0424	maF-like protein
JMW49_RS02890	COG1245	4Fe-4S binding domain
JMW49_RS02890	COG2878	Part of a membrane complex involved in electron transport
JMW49_RS02895	COG4657	Part of a membrane complex involved in electron transport
JMW49_RS02900	COG4660	Part of a membrane complex involved in electron transport
JMW49_RS02905	COG4659	FMN binding
JMW49_RS02910	COG4658	electron transport chain
JMW49_RS02915	COG4656	Part of a membrane complex involved in electron transport
JMW49_RS02925	COG0791	NLP P60 protein
JMW49_RS02930	COG0346	lactoylglutathione lyase activity
JMW49_RS02955	COG0237	dephospho-CoA kinase activity
JMW49_RS02960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JMW49_RS02960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JMW49_RS02995	COG2207	Transcriptional regulator
JMW49_RS02995	COG3708	Transcriptional regulator
JMW49_RS03020	COG1396	sequence-specific DNA binding
JMW49_RS03025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JMW49_RS03030	COG1882	Formate acetyltransferase
JMW49_RS03045	COG3279	Response regulator of the LytR AlgR family
JMW49_RS03060	COG1473	amidohydrolase
JMW49_RS03070	COG1132	(ABC) transporter
JMW49_RS03075	COG3414	Phosphotransferase system galactitol-specific IIB component
JMW49_RS03095	COG0583	DNA-binding transcription factor activity
JMW49_RS03100	COG3716	PTS system mannose fructose sorbose family IID component
JMW49_RS03105	COG3715	PTS system
JMW49_RS03125	COG2188	Transcriptional regulator
JMW49_RS03130	COG1362	aminopeptidase activity
JMW49_RS03135	COG4224	UPF0291 protein
JMW49_RS03140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS03145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JMW49_RS03200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JMW49_RS03210	COG0564	pseudouridine synthase activity
JMW49_RS03215	COG0183	Belongs to the thiolase family
JMW49_RS03230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JMW49_RS03235	COG2086	electron transfer activity
JMW49_RS03240	COG1960	acyl-CoA dehydrogenase activity
JMW49_RS03245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JMW49_RS03260	COG1131	(ABC) transporter
JMW49_RS03265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JMW49_RS03270	COG0622	Phosphoesterase
JMW49_RS03280	COG2195	Cleaves the N-terminal amino acid of tripeptides
JMW49_RS03290	COG4536	flavin adenine dinucleotide binding
JMW49_RS03295	COG0419	ATPase involved in DNA repair
JMW49_RS03300	COG0420	3'-5' exonuclease activity
JMW49_RS03305	COG1074	ATP-dependent DNA helicase activity
JMW49_RS03310	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JMW49_RS03320	COG1074	ATP-dependent DNA helicase activity
JMW49_RS03330	COG2247	cell wall binding repeat
JMW49_RS03330	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS03335	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS03365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JMW49_RS03380	COG1215	transferase activity, transferring glycosyl groups
JMW49_RS03385	COG5298	Protein conserved in bacteria
JMW49_RS03395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JMW49_RS03400	COG1177	transmembrane transport
JMW49_RS03405	COG1176	ABC-type spermidine putrescine transport system, permease component I
JMW49_RS03410	COG3842	ATPase activity
JMW49_RS03420	COG2364	Membrane
JMW49_RS03440	COG1132	(ABC) transporter
JMW49_RS03450	COG4978	Transcriptional regulator
JMW49_RS03450	COG0789	Transcriptional regulator
JMW49_RS03460	COG5001	Diguanylate cyclase
JMW49_RS03465	COG5002	protein histidine kinase activity
JMW49_RS03480	COG0363	glucosamine-6-phosphate deaminase activity
JMW49_RS03485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JMW49_RS03505	COG0577	efflux transmembrane transporter activity
JMW49_RS03505	COG1136	(ABC) transporter
JMW49_RS03510	COG5002	protein histidine kinase activity
JMW49_RS03515	COG0745	RESPONSE REGULATOR receiver
JMW49_RS03530	COG0281	malic enzyme
JMW49_RS03540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JMW49_RS03545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JMW49_RS03570	COG5002	protein histidine kinase activity
JMW49_RS03570	COG3447	MASE1 domain protein
JMW49_RS03570	COG5001	Diguanylate cyclase
JMW49_RS03580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JMW49_RS03595	COG0473	3-isopropylmalate dehydrogenase activity
JMW49_RS03600	COG0066	3-isopropylmalate dehydratase activity
JMW49_RS03605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JMW49_RS03610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JMW49_RS03620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JMW49_RS03625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JMW49_RS03625	COG0539	negative regulation of cytoplasmic translation
JMW49_RS03630	COG0534	Mate efflux family protein
JMW49_RS03660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JMW49_RS03665	COG1174	glycine betaine transport
JMW49_RS03675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JMW49_RS03680	COG4868	Belongs to the UPF0371 family
JMW49_RS03715	COG0010	Belongs to the arginase family
JMW49_RS03720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JMW49_RS03725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JMW49_RS03730	COG1982	Orn Lys Arg decarboxylase major
JMW49_RS03735	COG1802	Transcriptional regulator
JMW49_RS03745	COG0058	SHG alpha-glucan phosphorylase activity
JMW49_RS03750	COG0297	glycogen (starch) synthase activity
JMW49_RS03755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JMW49_RS03760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JMW49_RS03775	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JMW49_RS03775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JMW49_RS03780	COG4120	Belongs to the binding-protein-dependent transport system permease family
JMW49_RS03790	COG2984	ABC transporter substrate binding protein
JMW49_RS03795	COG4120	Belongs to the binding-protein-dependent transport system permease family
JMW49_RS03810	COG0110	maltose O-acetyltransferase activity
JMW49_RS03815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JMW49_RS03820	COG4149	molybdate abc transporter
JMW49_RS03825	COG0725	ABC transporter, periplasmic molybdate-binding protein
JMW49_RS03830	COG1910	domain protein
JMW49_RS03840	COG1073	alpha beta
JMW49_RS03850	COG1486	melibiose metabolic process
JMW49_RS03860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS03875	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JMW49_RS03875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JMW49_RS03880	COG4608	Belongs to the ABC transporter superfamily
JMW49_RS03885	COG0444	Belongs to the ABC transporter superfamily
JMW49_RS03895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JMW49_RS03900	COG0601	transmembrane transport
JMW49_RS03915	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JMW49_RS03970	COG0438	transferase activity, transferring glycosyl groups
JMW49_RS03970	COG0297	glycogen (starch) synthase activity
JMW49_RS03980	COG0138	bifunctional purine biosynthesis protein purh
JMW49_RS03985	COG0179	Fumarylacetoacetate (FAA) hydrolase
JMW49_RS04010	COG1846	Transcriptional regulator
JMW49_RS04015	COG0473	3-isopropylmalate dehydrogenase activity
JMW49_RS04025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JMW49_RS04065	COG0069	glutamate synthase activity
JMW49_RS04070	COG2033	superoxide reductase activity
JMW49_RS04080	COG1592	Rubrerythrin
JMW49_RS04100	COG5002	protein histidine kinase activity
JMW49_RS04105	COG0745	RESPONSE REGULATOR receiver
JMW49_RS04115	COG2723	6-phospho-beta-galactosidase activity
JMW49_RS04120	COG1263	PTS System
JMW49_RS04120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS04120	COG2190	(PTS) system
JMW49_RS04125	COG2814	Major facilitator Superfamily
JMW49_RS04130	COG2186	Transcriptional regulator
JMW49_RS04170	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JMW49_RS04175	COG2086	electron transfer activity
JMW49_RS04190	COG2610	gluconate transmembrane transporter activity
JMW49_RS04195	COG1024	Enoyl-CoA hydratase
JMW49_RS04200	COG0217	transcriptional regulatory protein
JMW49_RS04205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JMW49_RS04210	COG0730	response to heat
JMW49_RS04220	COG1739	Uncharacterized protein family UPF0029
JMW49_RS04235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JMW49_RS04250	COG0488	(ABC) transporter
JMW49_RS04255	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS04260	COG0750	zinc metalloprotease
JMW49_RS04270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JMW49_RS04280	COG1473	amidohydrolase
JMW49_RS04305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JMW49_RS04315	COG1191	sigma factor activity
JMW49_RS04320	COG2172	sigma factor antagonist activity
JMW49_RS04325	COG1366	Belongs to the anti-sigma-factor antagonist family
JMW49_RS04330	COG0243	molybdopterin cofactor binding
JMW49_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
JMW49_RS04365	COG0513	Belongs to the DEAD box helicase family
JMW49_RS04370	COG0530	calcium, potassium:sodium antiporter activity
JMW49_RS04380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JMW49_RS04385	COG0778	Nitroreductase
JMW49_RS04395	COG0301	tRNA thio-modification
JMW49_RS04405	COG1126	abc transporter atp-binding protein
JMW49_RS04410	COG0765	amino acid transport
JMW49_RS04415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JMW49_RS04420	COG0210	DNA helicase
JMW49_RS04440	COG1360	Flagellar Motor Protein
JMW49_RS04445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JMW49_RS04455	COG1349	DNA-binding transcription factor activity
JMW49_RS04460	COG3192	ethanolamine utilization protein
JMW49_RS04470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JMW49_RS04470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JMW49_RS04485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JMW49_RS04505	COG0095	Lipoate-protein ligase
JMW49_RS04525	COG0509	glycine decarboxylation via glycine cleavage system
JMW49_RS04555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JMW49_RS04560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JMW49_RS04560	COG0646	methionine synthase
JMW49_RS04570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JMW49_RS04575	COG3404	Formiminotransferase-cyclodeaminase
JMW49_RS04580	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JMW49_RS04590	COG1151	hydroxylamine reductase activity
JMW49_RS04595	COG0280	phosphate acetyltransferase
JMW49_RS04600	COG0110	maltose O-acetyltransferase activity
JMW49_RS04605	COG0583	DNA-binding transcription factor activity
JMW49_RS04630	COG0018	arginyl-trna synthetase
JMW49_RS04635	COG1683	Conserved Protein
JMW49_RS04640	COG1193	negative regulation of DNA recombination
JMW49_RS04645	COG2195	Cleaves the N-terminal amino acid of tripeptides
JMW49_RS04650	COG3706	GGDEF domain
JMW49_RS04660	COG1051	belongs to the nudix hydrolase family
JMW49_RS04670	COG0826	peptidase U32
JMW49_RS04690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JMW49_RS04690	COG0072	phenylalanine-tRNA ligase activity
JMW49_RS04695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JMW49_RS04700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JMW49_RS04705	COG0569	domain protein
JMW49_RS04710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JMW49_RS04730	COG0789	Transcriptional regulator
JMW49_RS04775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JMW49_RS04780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JMW49_RS04785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JMW49_RS04795	COG1595	DNA-templated transcription, initiation
JMW49_RS04830	COG0745	RESPONSE REGULATOR receiver
JMW49_RS04830	COG3292	Two component regulator propeller
JMW49_RS04830	COG2205	protein histidine kinase activity
JMW49_RS04835	COG0745	RESPONSE REGULATOR receiver
JMW49_RS04915	COG0038	chloride channel
JMW49_RS04935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS04945	COG4946	Tricorn protease homolog
JMW49_RS04945	COG1506	peptidase
JMW49_RS04945	COG0823	Involved in the tonB-independent uptake of proteins
JMW49_RS04950	COG1506	peptidase
JMW49_RS04950	COG4946	Tricorn protease homolog
JMW49_RS04950	COG0823	Involved in the tonB-independent uptake of proteins
JMW49_RS04955	COG1802	Transcriptional regulator
JMW49_RS04960	COG1131	(ABC) transporter
JMW49_RS05015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JMW49_RS05035	COG0305	Participates in initiation and elongation during chromosome replication
JMW49_RS05075	COG0789	Transcriptional regulator
JMW49_RS05075	COG4978	Transcriptional regulator
JMW49_RS05110	COG0456	acetyltransferase
JMW49_RS05110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JMW49_RS05125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JMW49_RS05135	COG3546	catalase activity
JMW49_RS05150	COG1475	DNA binding
JMW49_RS05155	COG3969	phosphoadenosine phosphosulfate
JMW49_RS05195	COG2199	diguanylate cyclase activity
JMW49_RS05200	COG1716	ATPase activity
JMW49_RS05200	COG5001	Diguanylate cyclase
JMW49_RS05205	COG3848	Pyruvate phosphate dikinase
JMW49_RS05205	COG0574	Belongs to the PEP-utilizing enzyme family
JMW49_RS05210	COG1309	transcriptional regulator
JMW49_RS05255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JMW49_RS05260	COG4399	Belongs to the UPF0754 family
JMW49_RS05260	COG4399	Belongs to the UPF0754 family
JMW49_RS05290	COG1744	ABC transporter substrate-binding protein PnrA-like
JMW49_RS05300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JMW49_RS05305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JMW49_RS05310	COG1067	ATP-dependent peptidase activity
JMW49_RS05315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JMW49_RS05330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JMW49_RS05340	COG2066	Belongs to the glutaminase family
JMW49_RS05345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JMW49_RS05360	COG0681	Belongs to the peptidase S26 family
JMW49_RS05365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JMW49_RS05365	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JMW49_RS05370	COG2339	peptidase activity
JMW49_RS05420	COG2201	protein-glutamate methylesterase activity
JMW49_RS05430	COG0835	chemotaxis
JMW49_RS05435	COG2198	Histidine kinase
JMW49_RS05435	COG0643	Histidine kinase
JMW49_RS05440	COG0840	transmembrane signaling receptor activity
JMW49_RS05450	COG0835	chemotaxis
JMW49_RS05455	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JMW49_RS05460	COG1776	CheC inhibitor of MCP methylation
JMW49_RS05465	COG2201	protein-glutamate methylesterase activity
JMW49_RS05475	COG2378	regulation of single-species biofilm formation
JMW49_RS05495	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JMW49_RS05500	COG2195	Cleaves the N-terminal amino acid of tripeptides
JMW49_RS05525	COG2205	protein histidine kinase activity
JMW49_RS05545	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JMW49_RS05545	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JMW49_RS05550	COG1686	Belongs to the peptidase S11 family
JMW49_RS05560	COG5002	protein histidine kinase activity
JMW49_RS05570	COG3716	PTS system mannose fructose sorbose family IID component
JMW49_RS05580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS05590	COG1063	alcohol dehydrogenase
JMW49_RS05605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JMW49_RS05610	COG0745	RESPONSE REGULATOR receiver
JMW49_RS05615	COG5002	protein histidine kinase activity
JMW49_RS05620	COG1136	(ABC) transporter
JMW49_RS05625	COG1136	(ABC) transporter
JMW49_RS05625	COG0577	efflux transmembrane transporter activity
JMW49_RS05630	COG5002	protein histidine kinase activity
JMW49_RS05635	COG0745	RESPONSE REGULATOR receiver
JMW49_RS05650	COG1131	(ABC) transporter
JMW49_RS05675	COG0768	penicillin binding
JMW49_RS05755	COG1595	DNA-templated transcription, initiation
JMW49_RS05825	COG1131	(ABC) transporter
JMW49_RS05845	COG0745	RESPONSE REGULATOR receiver
JMW49_RS05850	COG5002	protein histidine kinase activity
JMW49_RS05860	COG1136	(ABC) transporter
JMW49_RS05870	COG3973	AAA domain
JMW49_RS05880	COG1051	belongs to the nudix hydrolase family
JMW49_RS05895	COG1757	Na H antiporter
JMW49_RS05900	COG3457	Alanine racemase
JMW49_RS05910	COG5012	cobalamin binding
JMW49_RS05920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JMW49_RS05930	COG3804	dihydrodipicolinate reductase
JMW49_RS05935	COG3829	transcription factor binding
JMW49_RS05945	COG0626	cystathionine gamma-synthase activity
JMW49_RS05965	COG3254	rhamnose metabolic process
JMW49_RS05980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JMW49_RS05990	COG0745	RESPONSE REGULATOR receiver
JMW49_RS05995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JMW49_RS06045	COG1187	pseudouridine synthase activity
JMW49_RS06055	COG0191	fructose-bisphosphate aldolase activity
JMW49_RS06060	COG3829	transcription factor binding
JMW49_RS06065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JMW49_RS06070	COG2086	electron transfer activity
JMW49_RS06075	COG1960	acyl-CoA dehydrogenase activity
JMW49_RS06100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JMW49_RS06115	COG0367	asparagine synthase
JMW49_RS06120	COG3711	transcriptional antiterminator
JMW49_RS06125	COG2723	6-phospho-beta-galactosidase activity
JMW49_RS06130	COG2190	(PTS) system
JMW49_RS06130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS06130	COG1263	PTS System
JMW49_RS06155	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
JMW49_RS06175	COG2357	RelA SpoT domain protein
JMW49_RS06180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JMW49_RS06210	COG1136	(ABC) transporter
JMW49_RS06220	COG1454	alcohol dehydrogenase
JMW49_RS06220	COG1012	belongs to the aldehyde dehydrogenase family
JMW49_RS06235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JMW49_RS06245	COG1362	aminopeptidase activity
JMW49_RS06250	COG0210	DNA helicase
JMW49_RS06255	COG1122	ATPase activity
JMW49_RS06265	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
JMW49_RS06285	COG0586	Pfam SNARE associated Golgi protein
JMW49_RS06305	COG2217	Heavy metal translocating P-type atpase
JMW49_RS06345	COG1473	amidohydrolase
JMW49_RS06355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMW49_RS06360	COG1172	Belongs to the binding-protein-dependent transport system permease family
JMW49_RS06365	COG1129	ABC transporter
JMW49_RS06370	COG1879	ABC-type sugar transport system periplasmic component
JMW49_RS06375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JMW49_RS06385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JMW49_RS06405	COG1131	(ABC) transporter
JMW49_RS06425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMW49_RS06435	COG3716	PTS system mannose fructose sorbose family IID component
JMW49_RS06460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JMW49_RS06460	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JMW49_RS06465	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JMW49_RS06465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JMW49_RS06470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JMW49_RS06485	COG1733	regulation of RNA biosynthetic process
JMW49_RS06500	COG1533	DNA photolyase activity
JMW49_RS06505	COG1454	alcohol dehydrogenase
JMW49_RS06550	COG1215	transferase activity, transferring glycosyl groups
JMW49_RS06560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JMW49_RS06570	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JMW49_RS06585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JMW49_RS06590	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
JMW49_RS06625	COG0741	lytic transglycosylase activity
JMW49_RS06630	COG1088	dTDP-glucose 4,6-dehydratase activity
JMW49_RS06640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JMW49_RS06655	COG0138	bifunctional purine biosynthesis protein purh
JMW49_RS06660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JMW49_RS06665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JMW49_RS06670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JMW49_RS06675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JMW49_RS06680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JMW49_RS06685	COG0778	Nitroreductase
JMW49_RS06700	COG1011	Hydrolase
JMW49_RS06710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS06715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS06730	COG2771	luxR family
JMW49_RS06730	COG2200	EAL domain
JMW49_RS06735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JMW49_RS06790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JMW49_RS06790	COG0519	Catalyzes the synthesis of GMP from XMP
JMW49_RS06795	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
JMW49_RS06800	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
JMW49_RS06805	COG1691	(AIR) carboxylase
JMW49_RS06810	COG0459	protein refolding
JMW49_RS06815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JMW49_RS06820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JMW49_RS06835	COG0583	DNA-binding transcription factor activity
JMW49_RS06845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JMW49_RS06850	COG0167	dihydroorotate dehydrogenase activity
JMW49_RS06855	COG0543	2 iron, 2 sulfur cluster binding
JMW49_RS06860	COG0540	Belongs to the ATCase OTCase family
JMW49_RS06900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JMW49_RS06915	COG1151	hydroxylamine reductase activity
JMW49_RS06925	COG2221	Nitrite and sulphite reductase 4Fe-4S
JMW49_RS06935	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JMW49_RS06940	COG0488	(ABC) transporter
JMW49_RS06945	COG0534	Mate efflux family protein
JMW49_RS06975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JMW49_RS06985	COG1882	Formate acetyltransferase
JMW49_RS06990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JMW49_RS06995	COG0456	acetyltransferase
JMW49_RS07000	COG1214	PFAM Peptidase M22, glycoprotease
JMW49_RS07005	COG0802	atpase or kinase
JMW49_RS07020	COG1228	amidohydrolase
JMW49_RS07025	COG2183	response to ionizing radiation
JMW49_RS07035	COG0653	protein targeting
JMW49_RS07040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JMW49_RS07050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMW49_RS07055	COG1446	asparaginase
JMW49_RS07065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS07070	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS07075	COG1447	Phosphotransferase system cellobiose-specific component IIA
JMW49_RS07080	COG3711	transcriptional antiterminator
JMW49_RS07080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS07085	COG1040	competence protein
JMW49_RS07090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JMW49_RS07095	COG3949	Membrane
JMW49_RS07100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JMW49_RS07110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JMW49_RS07115	COG1077	Cell shape determining protein MreB Mrl
JMW49_RS07120	COG1609	Transcriptional regulator
JMW49_RS07130	COG2385	sporulation resulting in formation of a cellular spore
JMW49_RS07135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JMW49_RS07145	COG2897	thiosulfate sulfurtransferase activity
JMW49_RS07150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JMW49_RS07155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JMW49_RS07190	COG0280	phosphate acetyltransferase
JMW49_RS07200	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JMW49_RS07445	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS07450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JMW49_RS07455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JMW49_RS07460	COG0101	tRNA pseudouridine synthase activity
JMW49_RS07465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JMW49_RS07470	COG1122	ATPase activity
JMW49_RS07475	COG1122	ATPase activity
JMW49_RS07480	COG0203	ribosomal protein L17
JMW49_RS07485	COG0202	RNA polymerase activity
JMW49_RS07490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JMW49_RS07495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JMW49_RS07500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JMW49_RS07505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JMW49_RS07510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JMW49_RS07520	COG0024	Methionine aminopeptidase
JMW49_RS07525	COG0563	adenylate kinase activity
JMW49_RS07535	COG0200	Binds to the 23S rRNA
JMW49_RS07540	COG1841	ribosomal large subunit assembly
JMW49_RS07545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JMW49_RS07550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JMW49_RS07555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JMW49_RS07560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JMW49_RS07565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JMW49_RS07570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JMW49_RS07575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JMW49_RS07580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JMW49_RS07585	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JMW49_RS07590	COG0255	Belongs to the universal ribosomal protein uL29 family
JMW49_RS07595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JMW49_RS07600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JMW49_RS07605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JMW49_RS07610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JMW49_RS07615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JMW49_RS07620	COG0089	rRNA binding
JMW49_RS07625	COG0088	Forms part of the polypeptide exit tunnel
JMW49_RS07630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JMW49_RS07635	COG0051	transcription antitermination factor activity, RNA binding
JMW49_RS07640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JMW49_RS07645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JMW49_RS07650	COG0049	tRNA binding
JMW49_RS07655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JMW49_RS07660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JMW49_RS07665	COG0085	RNA polymerase activity
JMW49_RS07675	COG0222	ribosome binding
JMW49_RS07680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JMW49_RS07685	COG0081	regulation of translation
JMW49_RS07690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JMW49_RS07695	COG0250	Participates in transcription elongation, termination and antitermination
JMW49_RS07705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JMW49_RS07710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JMW49_RS07720	COG3688	RNA-binding protein containing a PIN domain
JMW49_RS07725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JMW49_RS07740	COG0215	cysteine-tRNA ligase activity
JMW49_RS07750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JMW49_RS07755	COG0442	prolyl-tRNA aminoacylation
JMW49_RS07760	COG0442	prolyl-tRNA aminoacylation
JMW49_RS07765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JMW49_RS07770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JMW49_RS07775	COG0095	Lipoate-protein ligase
JMW49_RS07790	COG3775	system Galactitol-specific IIC component
JMW49_RS07795	COG3414	Phosphotransferase system galactitol-specific IIB component
JMW49_RS07805	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JMW49_RS07805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JMW49_RS07810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JMW49_RS07815	COG0508	dehydrogenase complex catalyzes the overall conversion of
JMW49_RS07820	COG0022	dehydrogenase e1 component
JMW49_RS07825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JMW49_RS07830	COG2390	Transcriptional regulator
JMW49_RS07840	COG0745	RESPONSE REGULATOR receiver
JMW49_RS07845	COG2205	protein histidine kinase activity
JMW49_RS07855	COG3507	Belongs to the glycosyl hydrolase 43 family
JMW49_RS07875	COG4956	integral membrane protein (PIN domain superfamily)
JMW49_RS07880	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JMW49_RS07885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JMW49_RS07890	COG0542	response to heat
JMW49_RS07895	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JMW49_RS07900	COG3880	PFAM UvrB UvrC protein
JMW49_RS07905	COG4463	regulation of RNA biosynthetic process
JMW49_RS07910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JMW49_RS07915	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JMW49_RS08155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JMW49_RS08165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JMW49_RS08170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JMW49_RS08175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JMW49_RS08190	COG0590	tRNA wobble adenosine to inosine editing
JMW49_RS08195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JMW49_RS08200	COG0668	transmembrane transport
JMW49_RS08205	COG1827	regulation of RNA biosynthetic process
JMW49_RS08255	COG1191	sigma factor activity
JMW49_RS08265	COG1366	Belongs to the anti-sigma-factor antagonist family
JMW49_RS08280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JMW49_RS08285	COG0187	DNA topoisomerase II activity
JMW49_RS08290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JMW49_RS08300	COG0592	DNA-directed DNA polymerase activity
JMW49_RS08305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JMW49_RS08310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JMW49_RS08315	COG0594	ribonuclease P activity
JMW49_RS08320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JMW49_RS08325	COG0706	membrane insertase activity
JMW49_RS08330	COG1847	R3H domain protein
JMW49_RS08335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JMW49_RS08340	COG0445	tRNA wobble uridine modification
JMW49_RS08345	COG0357	Ribosomal RNA small subunit methyltransferase G
JMW49_RS08350	COG1475	DNA binding
JMW49_RS08355	COG1192	Involved in chromosome partitioning
JMW49_RS08360	COG1475	DNA binding
JMW49_RS08365	COG1104	cysteine desulfurase activity
JMW49_RS08380	COG0425	Belongs to the sulfur carrier protein TusA family
JMW49_RS08395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS08400	COG0360	Binds together with S18 to 16S ribosomal RNA
JMW49_RS08405	COG0629	single-stranded DNA binding
JMW49_RS08410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JMW49_RS08425	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JMW49_RS08430	COG0359	binds to the 23S rRNA
JMW49_RS08435	COG0305	Participates in initiation and elongation during chromosome replication
JMW49_RS08445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JMW49_RS08470	COG1484	DNA-dependent DNA replication
JMW49_RS08485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JMW49_RS08490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS08495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JMW49_RS08500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS08505	COG1447	Phosphotransferase system cellobiose-specific component IIA
JMW49_RS08510	COG2188	Transcriptional regulator
JMW49_RS08515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS08525	COG3964	amidohydrolase
JMW49_RS08540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JMW49_RS08540	COG1522	sequence-specific DNA binding
JMW49_RS08545	COG0583	DNA-binding transcription factor activity
JMW49_RS08575	COG1335	isochorismatase
JMW49_RS08595	COG0517	IMP dehydrogenase activity
JMW49_RS08595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JMW49_RS08600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JMW49_RS08615	COG1473	amidohydrolase
JMW49_RS08625	COG5001	Diguanylate cyclase
JMW49_RS08625	COG3447	MASE1 domain protein
JMW49_RS08625	COG5002	protein histidine kinase activity
JMW49_RS08635	COG0577	efflux transmembrane transporter activity
JMW49_RS08635	COG1136	(ABC) transporter
JMW49_RS08640	COG2824	Alkylphosphonate utilization operon protein PhnA
JMW49_RS08645	COG1357	PFAM Pentapeptide repeats (8 copies)
JMW49_RS08655	COG0519	Catalyzes the synthesis of GMP from XMP
JMW49_RS08665	COG5504	Zn-dependent protease
JMW49_RS08670	COG3263	regulation of cellular component size
JMW49_RS08675	COG4978	Transcriptional regulator
JMW49_RS08675	COG0789	Transcriptional regulator
JMW49_RS08690	COG0534	Mate efflux family protein
JMW49_RS08695	COG0346	lactoylglutathione lyase activity
JMW49_RS08705	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JMW49_RS08715	COG3964	amidohydrolase
JMW49_RS08720	COG1141	Ferredoxin
JMW49_RS08735	COG1408	metallophosphoesterase
JMW49_RS08740	COG0037	tRNA processing
JMW49_RS08745	COG1876	peptidase activity
JMW49_RS08760	COG1854	S-ribosylhomocysteine lyase activity
JMW49_RS08770	COG1410	methionine synthase
JMW49_RS08770	COG0646	methionine synthase
JMW49_RS08790	COG0284	orotidine-5'-phosphate decarboxylase activity
JMW49_RS08800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JMW49_RS08810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JMW49_RS08825	COG1695	Transcriptional regulator
JMW49_RS08835	COG2205	protein histidine kinase activity
JMW49_RS08840	COG1136	(ABC) transporter
JMW49_RS08840	COG0577	efflux transmembrane transporter activity
JMW49_RS08850	COG0789	Transcriptional regulator
JMW49_RS08850	COG4978	Transcriptional regulator
JMW49_RS08855	COG0564	pseudouridine synthase activity
JMW49_RS08880	COG0626	cystathionine gamma-synthase activity
JMW49_RS08885	COG2223	nitrite transmembrane transporter activity
JMW49_RS08910	COG0653	protein targeting
JMW49_RS08940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JMW49_RS08945	COG1802	Transcriptional regulator
JMW49_RS08960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JMW49_RS08970	COG0037	tRNA processing
JMW49_RS08975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JMW49_RS08985	COG3191	aminopeptidase activity
JMW49_RS08995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JMW49_RS09005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JMW49_RS09010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JMW49_RS09035	COG2155	Conserved Protein
JMW49_RS09040	COG1982	Orn Lys Arg decarboxylase major
JMW49_RS09050	COG0470	DNA polymerase III
JMW49_RS09055	COG1774	PSP1 C-terminal conserved region
JMW49_RS09060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JMW49_RS09065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JMW49_RS09070	COG0617	tRNA 3'-terminal CCA addition
JMW49_RS09075	COG1522	sequence-specific DNA binding
JMW49_RS09080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JMW49_RS09090	COG0700	Nucleoside recognition
JMW49_RS09095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JMW49_RS09095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JMW49_RS09100	COG0084	hydrolase, TatD family'
JMW49_RS09110	COG0613	PHP domain protein
JMW49_RS09115	COG3842	ATPase activity
JMW49_RS09130	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JMW49_RS09135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JMW49_RS09145	COG2195	Cleaves the N-terminal amino acid of tripeptides
JMW49_RS09150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JMW49_RS09160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JMW49_RS09165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JMW49_RS09170	COG2088	sporulation resulting in formation of a cellular spore
JMW49_RS09175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JMW49_RS09190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JMW49_RS09240	COG0193	aminoacyl-tRNA hydrolase activity
JMW49_RS09245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JMW49_RS09250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JMW49_RS09255	COG2002	toxin-antitoxin pair type II binding
JMW49_RS09260	COG2244	polysaccharide biosynthetic process
JMW49_RS09265	COG3956	TIGRFAM MazG family protein
JMW49_RS09275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JMW49_RS09295	COG0248	Ppx GppA phosphatase
JMW49_RS09300	COG2208	phosphoserine phosphatase activity
JMW49_RS09310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JMW49_RS09315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JMW49_RS09320	COG0254	rRNA binding
JMW49_RS09325	COG3872	metal-dependent enzyme
JMW49_RS09330	COG2890	protein-(glutamine-N5) methyltransferase activity
JMW49_RS09335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JMW49_RS09345	COG0009	L-threonylcarbamoyladenylate synthase
JMW49_RS09350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JMW49_RS09355	COG0698	ribose 5-phosphate isomerase
JMW49_RS09360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JMW49_RS09365	COG3608	succinylglutamate desuccinylase aspartoacylase
JMW49_RS09365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JMW49_RS09390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JMW49_RS09395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JMW49_RS09400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JMW49_RS09405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JMW49_RS09410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JMW49_RS09415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JMW49_RS09420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JMW49_RS09425	COG0736	holo-[acyl-carrier-protein] synthase activity
JMW49_RS09430	COG0516	GMP reductase activity
JMW49_RS09430	COG0517	IMP dehydrogenase activity
JMW49_RS09450	COG2337	Toxic component of a toxin-antitoxin (TA) module
JMW49_RS09455	COG3959	Transketolase, thiamine diphosphate binding domain
JMW49_RS09460	COG3958	Transketolase
JMW49_RS09465	COG3949	Membrane
JMW49_RS09475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JMW49_RS09480	COG0793	Belongs to the peptidase S41A family
JMW49_RS09480	COG3409	Peptidoglycan-binding domain 1 protein
JMW49_RS09490	COG2188	Transcriptional regulator
JMW49_RS09500	COG0673	inositol 2-dehydrogenase activity
JMW49_RS09505	COG2222	sugar isomerase
JMW49_RS09510	COG0191	fructose-bisphosphate aldolase activity
JMW49_RS09515	COG3711	transcriptional antiterminator
JMW49_RS09520	COG1363	Peptidase, m42
JMW49_RS09525	COG1447	Phosphotransferase system cellobiose-specific component IIA
JMW49_RS09530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS09545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JMW49_RS09560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JMW49_RS09570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JMW49_RS09580	COG1492	cobalamin metabolic process
JMW49_RS09585	COG1797	cobyrinic acid a,c-diamide synthase activity
JMW49_RS09595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMW49_RS09610	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JMW49_RS09650	COG0181	hydroxymethylbilane synthase activity
JMW49_RS09660	COG0113	porphobilinogen synthase activity
JMW49_RS09665	COG1648	precorrin-2 dehydrogenase activity
JMW49_RS09665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JMW49_RS09685	COG3842	ATPase activity
JMW49_RS09690	COG1175	transmembrane transport
JMW49_RS09700	COG1653	transport
JMW49_RS09710	COG0556	nucleotide-excision repair
JMW49_RS09720	COG0322	excinuclease ABC activity
JMW49_RS09750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JMW49_RS09755	COG2116	formate transmembrane transporter activity
JMW49_RS09760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JMW49_RS09770	COG1660	Displays ATPase and GTPase activities
JMW49_RS09785	COG1481	regulation of sporulation
JMW49_RS09795	COG0205	6-phosphofructokinase activity
JMW49_RS09840	COG2199	diguanylate cyclase activity
JMW49_RS09845	COG4555	ABC transporter
JMW49_RS09865	COG0745	RESPONSE REGULATOR receiver
JMW49_RS09870	COG0488	(ABC) transporter
JMW49_RS09885	COG1733	regulation of RNA biosynthetic process
JMW49_RS09890	COG0778	Nitroreductase
JMW49_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS09915	COG0463	Glycosyl transferase, family 2
JMW49_RS09915	COG0457	Tetratricopeptide repeat
JMW49_RS09965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JMW49_RS09970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JMW49_RS09980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JMW49_RS09980	COG0493	'glutamate synthase
JMW49_RS10000	COG2946	Replication initiation factor
JMW49_RS10055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JMW49_RS10070	COG0544	peptidyl-prolyl cis-trans isomerase activity
JMW49_RS10075	COG0740	serine-type endopeptidase activity
JMW49_RS10080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JMW49_RS10085	COG2059	Chromate
JMW49_RS10095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JMW49_RS10100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JMW49_RS10105	COG2814	Major facilitator Superfamily
JMW49_RS10120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JMW49_RS10125	COG1459	type II secretion system
JMW49_RS10150	COG3012	SEC-C Motif Domain Protein
JMW49_RS10150	COG1405	negative regulation of cell septum assembly
JMW49_RS10165	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
JMW49_RS10175	COG0166	Belongs to the GPI family
JMW49_RS10180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JMW49_RS10195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JMW49_RS10205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS10205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS10210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS10210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS10215	COG3715	PTS system
JMW49_RS10220	COG3716	PTS system mannose fructose sorbose family IID component
JMW49_RS10225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JMW49_RS10250	COG1285	pathogenesis
JMW49_RS10255	COG1164	Oligoendopeptidase f
JMW49_RS10260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JMW49_RS10265	COG0745	RESPONSE REGULATOR receiver
JMW49_RS10280	COG0573	inorganic phosphate transmembrane transporter activity
JMW49_RS10285	COG0581	inorganic phosphate transmembrane transporter activity
JMW49_RS10290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JMW49_RS10295	COG0704	Plays a role in the regulation of phosphate uptake
JMW49_RS10310	COG0726	polysaccharide deacetylase
JMW49_RS10315	COG0525	valine-tRNA ligase activity
JMW49_RS10320	COG3279	Response regulator of the LytR AlgR family
JMW49_RS10330	COG0285	dihydrofolate synthase activity
JMW49_RS10355	COG0726	polysaccharide deacetylase
JMW49_RS10360	COG4656	Part of a membrane complex involved in electron transport
JMW49_RS10375	COG5275	peptidyl-tyrosine sulfation
JMW49_RS10375	COG0252	asparaginase activity
JMW49_RS10390	COG0252	asparaginase activity
JMW49_RS10390	COG5275	peptidyl-tyrosine sulfation
JMW49_RS10395	COG0252	asparaginase activity
JMW49_RS10395	COG5275	peptidyl-tyrosine sulfation
JMW49_RS10420	COG2226	methyltransferase
JMW49_RS10430	COG3829	transcription factor binding
JMW49_RS10435	COG3681	Belongs to the UPF0597 family
JMW49_RS10440	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JMW49_RS10450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JMW49_RS10460	COG2171	N-acyltransferase activity
JMW49_RS10465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JMW49_RS10470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JMW49_RS10475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JMW49_RS10480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JMW49_RS10485	COG1760	l-serine dehydratase
JMW49_RS10490	COG1473	amidohydrolase
JMW49_RS10500	COG2226	methyltransferase
JMW49_RS10505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JMW49_RS10515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JMW49_RS10520	COG1732	Glycine betaine
JMW49_RS10555	COG0534	Mate efflux family protein
JMW49_RS10565	COG0778	Nitroreductase
JMW49_RS10575	COG0706	membrane insertase activity
JMW49_RS10580	COG0745	RESPONSE REGULATOR receiver
JMW49_RS10585	COG2770	Histidine kinase
JMW49_RS10585	COG2205	protein histidine kinase activity
JMW49_RS10610	COG0789	Transcriptional regulator
JMW49_RS10620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JMW49_RS10645	COG0577	efflux transmembrane transporter activity
JMW49_RS10650	COG1136	(ABC) transporter
JMW49_RS10655	COG2247	cell wall binding repeat
JMW49_RS10655	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS10675	COG0789	Transcriptional regulator
JMW49_RS10680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JMW49_RS10690	COG0251	oxidation-reduction process
JMW49_RS10695	COG3829	transcription factor binding
JMW49_RS10710	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JMW49_RS10715	COG0402	S-adenosylhomocysteine deaminase activity
JMW49_RS10725	COG0167	dihydroorotate dehydrogenase activity
JMW49_RS10735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JMW49_RS10740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JMW49_RS10745	COG2390	Transcriptional regulator
JMW49_RS10755	COG0126	phosphoglycerate kinase activity
JMW49_RS10760	COG0149	triose-phosphate isomerase activity
JMW49_RS10765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JMW49_RS10770	COG0148	phosphopyruvate hydratase activity
JMW49_RS10800	COG1881	PFAM PEBP family protein
JMW49_RS10815	COG0557	exoribonuclease II activity
JMW49_RS10845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JMW49_RS10900	COG0693	protein deglycase activity
JMW49_RS10920	COG3711	transcriptional antiterminator
JMW49_RS10925	COG2190	(PTS) system
JMW49_RS10925	COG1263	PTS System
JMW49_RS10925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS10930	COG2723	6-phospho-beta-galactosidase activity
JMW49_RS10935	COG1840	ABC-type Fe3 transport system, periplasmic component
JMW49_RS10945	COG3842	ATPase activity
JMW49_RS10950	COG1178	ABC-type Fe3 transport system permease component
JMW49_RS10955	COG0191	fructose-bisphosphate aldolase activity
JMW49_RS10960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS10960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS10960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS10965	COG3711	transcriptional antiterminator
JMW49_RS10970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS10970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS10970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS10980	COG3711	transcriptional antiterminator
JMW49_RS10985	COG2190	(PTS) system
JMW49_RS10985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS10985	COG1263	PTS System
JMW49_RS10990	COG2723	6-phospho-beta-galactosidase activity
JMW49_RS11000	COG0640	Transcriptional regulator
JMW49_RS11010	COG1695	Transcriptional regulator
JMW49_RS11015	COG2223	nitrite transmembrane transporter activity
JMW49_RS11025	COG3620	sequence-specific DNA binding
JMW49_RS11030	COG1819	glycosyl
JMW49_RS11055	COG1136	(ABC) transporter
JMW49_RS11065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS11065	COG2190	(PTS) system
JMW49_RS11065	COG1263	PTS System
JMW49_RS11070	COG2723	6-phospho-beta-galactosidase activity
JMW49_RS11075	COG0778	Nitroreductase
JMW49_RS11080	COG1959	2 iron, 2 sulfur cluster binding
JMW49_RS11100	COG0205	6-phosphofructokinase activity
JMW49_RS11105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JMW49_RS11110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JMW49_RS11115	COG3711	transcriptional antiterminator
JMW49_RS11115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS11120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JMW49_RS11125	COG1454	alcohol dehydrogenase
JMW49_RS11130	COG0561	phosphatase activity
JMW49_RS11135	COG2190	(PTS) system
JMW49_RS11140	COG0745	RESPONSE REGULATOR receiver
JMW49_RS11155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JMW49_RS11170	COG1136	(ABC) transporter
JMW49_RS11175	COG1132	(ABC) transporter
JMW49_RS11185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMW49_RS11190	COG1263	PTS System
JMW49_RS11190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS11195	COG1288	antiporter activity
JMW49_RS11205	COG3711	transcriptional antiterminator
JMW49_RS11210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS11210	COG1263	PTS System
JMW49_RS11210	COG2190	(PTS) system
JMW49_RS11215	COG2723	6-phospho-beta-galactosidase activity
JMW49_RS11220	COG2723	6-phospho-beta-galactosidase activity
JMW49_RS11230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JMW49_RS11240	COG0366	Alpha amylase catalytic
JMW49_RS11245	COG2188	Transcriptional regulator
JMW49_RS11250	COG1263	PTS System
JMW49_RS11250	COG2190	(PTS) system
JMW49_RS11250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS11255	COG3394	polysaccharide catabolic process
JMW49_RS11275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS11275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS11275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS11280	COG0191	fructose-bisphosphate aldolase activity
JMW49_RS11285	COG0366	Alpha amylase catalytic
JMW49_RS11315	COG3716	PTS system mannose fructose sorbose family IID component
JMW49_RS11320	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS11320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS11330	COG1940	carbohydrate kinase activity
JMW49_RS11335	COG1070	Carbohydrate kinase
JMW49_RS11355	COG1263	PTS System
JMW49_RS11355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS11370	COG2190	(PTS) system
JMW49_RS11380	COG1136	(ABC) transporter
JMW49_RS11395	COG0642	Histidine kinase
JMW49_RS11400	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JMW49_RS11415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS11425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JMW49_RS11430	COG2971	BadF BadG BcrA BcrD
JMW49_RS11445	COG1737	Transcriptional regulator
JMW49_RS11460	COG2267	carboxylic ester hydrolase activity
JMW49_RS11480	COG0542	response to heat
JMW49_RS11500	COG0384	phenazine biosynthesis protein PhzF
JMW49_RS11510	COG3118	belongs to the thioredoxin family
JMW49_RS11515	COG0492	ferredoxin-NADP+ reductase activity
JMW49_RS11525	COG5002	protein histidine kinase activity
JMW49_RS11545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JMW49_RS11565	COG4975	Glucose uptake
JMW49_RS11570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS11570	COG3711	transcriptional antiterminator
JMW49_RS11575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS11575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS11575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS11580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS11585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS11590	COG0383	alpha-mannosidase activity
JMW49_RS11595	COG1733	regulation of RNA biosynthetic process
JMW49_RS11600	COG0785	Cytochrome C biogenesis protein
JMW49_RS11605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JMW49_RS11615	COG1376	ErfK ybiS ycfS ynhG family protein
JMW49_RS11620	COG1454	alcohol dehydrogenase
JMW49_RS11645	COG0179	Fumarylacetoacetate (FAA) hydrolase
JMW49_RS11650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JMW49_RS11660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JMW49_RS11665	COG1120	ATPase activity
JMW49_RS11675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JMW49_RS11680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JMW49_RS11700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JMW49_RS11715	COG0745	RESPONSE REGULATOR receiver
JMW49_RS11720	COG2205	protein histidine kinase activity
JMW49_RS11725	COG1968	undecaprenyl-diphosphatase activity
JMW49_RS11730	COG1136	(ABC) transporter
JMW49_RS11735	COG0577	efflux transmembrane transporter activity
JMW49_RS11765	COG1203	CRISPR-associated helicase, Cas3
JMW49_RS11780	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JMW49_RS11800	COG1268	BioY protein
JMW49_RS11810	COG0318	PFAM AMP-dependent synthetase and ligase
JMW49_RS11820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JMW49_RS11830	COG1012	belongs to the aldehyde dehydrogenase family
JMW49_RS11830	COG1454	alcohol dehydrogenase
JMW49_RS11835	COG5001	Diguanylate cyclase
JMW49_RS11835	COG3300	MHYT domain
JMW49_RS11860	COG1269	ATP hydrolysis coupled proton transport
JMW49_RS11865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JMW49_RS11870	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
JMW49_RS11885	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
JMW49_RS11890	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
JMW49_RS11895	COG1394	ATPase activity, coupled to movement of substances
JMW49_RS11900	COG1840	ABC-type Fe3 transport system, periplasmic component
JMW49_RS11905	COG3842	ATPase activity
JMW49_RS11910	COG1178	ABC-type Fe3 transport system permease component
JMW49_RS11915	COG2188	Transcriptional regulator
JMW49_RS11925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS11925	COG1263	PTS System
JMW49_RS11930	COG0366	Alpha amylase catalytic
JMW49_RS11935	COG2188	Transcriptional regulator
JMW49_RS11945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JMW49_RS11950	COG1486	melibiose metabolic process
JMW49_RS11955	COG3394	polysaccharide catabolic process
JMW49_RS11960	COG1447	Phosphotransferase system cellobiose-specific component IIA
JMW49_RS11975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JMW49_RS11980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JMW49_RS11985	COG1120	ATPase activity
JMW49_RS12025	COG0312	modulator of DNA gyrase
JMW49_RS12030	COG0312	modulator of DNA gyrase
JMW49_RS12040	COG2267	carboxylic ester hydrolase activity
JMW49_RS12045	COG3290	protein histidine kinase activity
JMW49_RS12045	COG3829	transcription factor binding
JMW49_RS12065	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JMW49_RS12070	COG1253	flavin adenine dinucleotide binding
JMW49_RS12075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JMW49_RS12085	COG0673	inositol 2-dehydrogenase activity
JMW49_RS12095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JMW49_RS12100	COG1696	Membrane protein involved in D-alanine export
JMW49_RS12105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JMW49_RS12110	COG1349	DNA-binding transcription factor activity
JMW49_RS12115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JMW49_RS12115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JMW49_RS12120	COG1664	Polymer-forming cytoskeletal
JMW49_RS12130	COG0789	Transcriptional regulator
JMW49_RS12135	COG1592	Rubrerythrin
JMW49_RS12145	COG0604	alcohol dehydrogenase
JMW49_RS12160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JMW49_RS12175	COG3949	Membrane
JMW49_RS12180	COG1473	amidohydrolase
JMW49_RS12185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JMW49_RS12190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JMW49_RS12200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JMW49_RS12215	COG0697	spore germination
JMW49_RS12220	COG0436	Aminotransferase
JMW49_RS12255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JMW49_RS12265	COG1132	(ABC) transporter
JMW49_RS12285	COG2084	Dehydrogenase
JMW49_RS12290	COG2610	gluconate transmembrane transporter activity
JMW49_RS12325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JMW49_RS12330	COG0632	four-way junction helicase activity
JMW49_RS12335	COG2255	four-way junction helicase activity
JMW49_RS12340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JMW49_RS12350	COG0343	queuine tRNA-ribosyltransferase activity
JMW49_RS12370	COG2247	cell wall binding repeat
JMW49_RS12370	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12395	COG0653	protein targeting
JMW49_RS12410	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12410	COG2247	cell wall binding repeat
JMW49_RS12415	COG2246	polysaccharide biosynthetic process
JMW49_RS12425	COG2247	cell wall binding repeat
JMW49_RS12425	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12435	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JMW49_RS12445	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12445	COG2247	cell wall binding repeat
JMW49_RS12450	COG0728	peptidoglycan biosynthetic process
JMW49_RS12455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JMW49_RS12475	COG1216	Glycosyl transferase, family 2
JMW49_RS12480	COG1215	transferase activity, transferring glycosyl groups
JMW49_RS12480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JMW49_RS12485	COG1215	transferase activity, transferring glycosyl groups
JMW49_RS12495	COG1215	transferase activity, transferring glycosyl groups
JMW49_RS12500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JMW49_RS12505	COG0438	transferase activity, transferring glycosyl groups
JMW49_RS12515	COG0791	NLP P60 protein
JMW49_RS12520	COG1649	PFAM Uncharacterised BCR, COG1649
JMW49_RS12525	COG1316	TRANSCRIPTIONal
JMW49_RS12530	COG1316	TRANSCRIPTIONal
JMW49_RS12535	COG0561	phosphatase activity
JMW49_RS12545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JMW49_RS12550	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS12620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JMW49_RS12620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JMW49_RS12625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JMW49_RS12630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JMW49_RS12635	COG1490	D-aminoacyl-tRNA deacylase activity
JMW49_RS12640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JMW49_RS12645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JMW49_RS12650	COG0124	histidyl-tRNA synthetase
JMW49_RS12655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JMW49_RS12665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JMW49_RS12670	COG0583	DNA-binding transcription factor activity
JMW49_RS12675	COG2247	cell wall binding repeat
JMW49_RS12675	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12685	COG1757	Na H antiporter
JMW49_RS12690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JMW49_RS12720	COG1937	Protein conserved in bacteria
JMW49_RS12740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JMW49_RS12745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JMW49_RS12760	COG0745	RESPONSE REGULATOR receiver
JMW49_RS12765	COG0642	Histidine kinase
JMW49_RS12765	COG5002	protein histidine kinase activity
JMW49_RS12770	COG3069	C4-dicarboxylate transmembrane transporter activity
JMW49_RS12775	COG0726	polysaccharide deacetylase
JMW49_RS12795	COG4509	Sortase family
JMW49_RS12820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JMW49_RS12825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JMW49_RS12830	COG1376	ErfK ybiS ycfS ynhG family protein
JMW49_RS12840	COG0583	DNA-binding transcription factor activity
JMW49_RS12860	COG2271	Major facilitator Superfamily
JMW49_RS12870	COG0402	S-adenosylhomocysteine deaminase activity
JMW49_RS12875	COG2252	PERMEase
JMW49_RS12910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JMW49_RS12915	COG2502	aspartate--ammonia ligase
JMW49_RS12930	COG1388	LysM domain
JMW49_RS12930	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS12965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMW49_RS13015	COG4869	propanediol catabolic process
JMW49_RS13025	COG2340	Cysteine-rich secretory protein family
JMW49_RS13030	COG2610	gluconate transmembrane transporter activity
JMW49_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
JMW49_RS13045	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JMW49_RS13050	COG0183	Belongs to the thiolase family
JMW49_RS13055	COG0583	DNA-binding transcription factor activity
JMW49_RS13060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JMW49_RS13075	COG0444	Belongs to the ABC transporter superfamily
JMW49_RS13080	COG4608	Belongs to the ABC transporter superfamily
JMW49_RS13085	COG0025	NhaP-type Na H and K H
JMW49_RS13090	COG3711	transcriptional antiterminator
JMW49_RS13095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS13095	COG1263	PTS System
JMW49_RS13095	COG2190	(PTS) system
JMW49_RS13105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JMW49_RS13110	COG5001	Diguanylate cyclase
JMW49_RS13110	COG3300	MHYT domain
JMW49_RS13115	COG0012	GTP binding
JMW49_RS13125	COG0612	Peptidase, M16
JMW49_RS13130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JMW49_RS13135	COG0275	rRNA processing
JMW49_RS13145	COG0768	penicillin binding
JMW49_RS13150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JMW49_RS13155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JMW49_RS13160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JMW49_RS13165	COG0772	Belongs to the SEDS family
JMW49_RS13170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JMW49_RS13190	COG3856	small basic protein
JMW49_RS13195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JMW49_RS13210	COG1191	sigma factor activity
JMW49_RS13215	COG1191	sigma factor activity
JMW49_RS13220	COG1873	PFAM PRC-barrel domain
JMW49_RS13225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JMW49_RS13235	COG0745	RESPONSE REGULATOR receiver
JMW49_RS13240	COG5002	protein histidine kinase activity
JMW49_RS13265	COG1160	GTP binding
JMW49_RS13270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JMW49_RS13275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JMW49_RS13295	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JMW49_RS13305	COG3830	Belongs to the UPF0237 family
JMW49_RS13325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JMW49_RS13330	COG1799	cell septum assembly
JMW49_RS13340	COG2302	S4 RNA-binding domain
JMW49_RS13350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JMW49_RS13355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JMW49_RS13370	COG1307	EDD domain protein, DegV family
JMW49_RS13375	COG0006	proline dipeptidase activity
JMW49_RS13380	COG0531	amino acid
JMW49_RS13385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JMW49_RS13410	COG3275	phosphorelay sensor kinase activity
JMW49_RS13415	COG3279	Response regulator of the LytR AlgR family
JMW49_RS13420	COG1966	Carbon starvation protein
JMW49_RS13425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JMW49_RS13435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JMW49_RS13440	COG0564	pseudouridine synthase activity
JMW49_RS13445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JMW49_RS13455	COG0488	(ABC) transporter
JMW49_RS13460	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JMW49_RS13470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JMW49_RS13475	COG1561	YicC-like family, N-terminal region
JMW49_RS13480	COG0194	GDP metabolic process
JMW49_RS13485	COG1758	RNA polymerase activity
JMW49_RS13490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JMW49_RS13495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JMW49_RS13500	COG0242	peptide deformylase activity
JMW49_RS13505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JMW49_RS13515	COG2738	Putative neutral zinc metallopeptidase
JMW49_RS13520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JMW49_RS13520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JMW49_RS13525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JMW49_RS13535	COG0515	serine threonine protein kinase
JMW49_RS13535	COG2815	serine threonine protein kinase
JMW49_RS13540	COG1028	Short-chain dehydrogenase reductase Sdr
JMW49_RS13545	COG1162	GTPase activity
JMW49_RS13550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JMW49_RS13555	COG1564	THIamine pyrophosphokinase
JMW49_RS13575	COG5002	protein histidine kinase activity
JMW49_RS13580	COG0383	alpha-mannosidase activity
JMW49_RS13585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS13590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS13590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS13590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS13595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS13595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS13595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS13600	COG3711	transcriptional antiterminator
JMW49_RS13600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS13605	COG0789	Transcriptional regulator
JMW49_RS13620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JMW49_RS13625	COG1302	Protein conserved in bacteria
JMW49_RS13630	COG1461	Dihydroxyacetone kinase
JMW49_RS13635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JMW49_RS13640	COG0742	ribosomal rna small subunit methyltransferase
JMW49_RS13665	COG0395	ABC-type sugar transport system, permease component
JMW49_RS13685	COG4124	Belongs to the glycosyl hydrolase 26 family
JMW49_RS13685	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JMW49_RS13710	COG1823	symporter activity
JMW49_RS13715	COG0446	pyridine nucleotide-disulphide oxidoreductase
JMW49_RS13720	COG1234	tRNA 3'-trailer cleavage
JMW49_RS13730	COG0737	Belongs to the 5'-nucleotidase family
JMW49_RS13735	COG0745	RESPONSE REGULATOR receiver
JMW49_RS13745	COG1136	(ABC) transporter
JMW49_RS13745	COG0577	efflux transmembrane transporter activity
JMW49_RS13790	COG1309	transcriptional regulator
JMW49_RS13795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JMW49_RS13800	COG2137	regulation of response to DNA damage stimulus
JMW49_RS13805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JMW49_RS13810	COG1713	HD superfamily hydrolase involved in NAD metabolism
JMW49_RS13815	COG0799	negative regulation of ribosome biogenesis
JMW49_RS13820	COG0495	leucyl-tRNA aminoacylation
JMW49_RS13860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JMW49_RS13865	COG0251	oxidation-reduction process
JMW49_RS13870	COG2190	(PTS) system
JMW49_RS13870	COG1263	PTS System
JMW49_RS13870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS13875	COG3711	transcriptional antiterminator
JMW49_RS13880	COG1263	PTS System
JMW49_RS13880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JMW49_RS13900	COG2814	Major facilitator Superfamily
JMW49_RS13905	COG1309	transcriptional regulator
JMW49_RS13910	COG1876	peptidase activity
JMW49_RS13915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JMW49_RS13920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMW49_RS13925	COG0561	phosphatase activity
JMW49_RS13930	COG0165	Argininosuccinate lyase
JMW49_RS13940	COG1686	Belongs to the peptidase S11 family
JMW49_RS13965	COG5002	protein histidine kinase activity
JMW49_RS13970	COG1482	cell wall glycoprotein biosynthetic process
JMW49_RS13975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMW49_RS13980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS13980	COG3711	transcriptional antiterminator
JMW49_RS13990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS13995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS14000	COG0006	proline dipeptidase activity
JMW49_RS14005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JMW49_RS14010	COG1396	sequence-specific DNA binding
JMW49_RS14030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JMW49_RS14035	COG3584	3D domain protein
JMW49_RS14035	COG1388	LysM domain
JMW49_RS14045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JMW49_RS14050	COG2333	competence protein COMEC
JMW49_RS14050	COG0658	competence protein
JMW49_RS14065	COG2333	competence protein COMEC
JMW49_RS14065	COG0658	competence protein
JMW49_RS14075	COG0268	Binds directly to 16S ribosomal RNA
JMW49_RS14100	COG0481	GTPase activity
JMW49_RS14105	COG0617	tRNA 3'-terminal CCA addition
JMW49_RS14110	COG0531	amino acid
JMW49_RS14115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JMW49_RS14120	COG1420	regulation of RNA biosynthetic process
JMW49_RS14125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JMW49_RS14130	COG0443	Heat shock 70 kDa protein
JMW49_RS14135	COG0484	heat shock protein binding
JMW49_RS14145	COG0477	Major facilitator Superfamily
JMW49_RS14150	COG2508	Transcriptional regulator
JMW49_RS14155	COG3842	ATPase activity
JMW49_RS14190	COG2264	protein methyltransferase activity
JMW49_RS14195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JMW49_RS14200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JMW49_RS14205	COG0537	adenosine 5'-monophosphoramidase activity
JMW49_RS14210	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JMW49_RS14215	COG1610	YqeY-like protein
JMW49_RS14220	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
JMW49_RS14225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JMW49_RS14240	COG1702	phosphate starvation-inducible protein PhoH
JMW49_RS14245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JMW49_RS14250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JMW49_RS14255	COG0295	cytidine deaminase activity
JMW49_RS14260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JMW49_RS14265	COG2239	Acts as a magnesium transporter
JMW49_RS14275	COG1381	Involved in DNA repair and RecF pathway recombination
JMW49_RS14285	COG0752	glycyl-tRNA synthetase alpha subunit
JMW49_RS14290	COG0751	glycine-tRNA ligase activity
JMW49_RS14300	COG1414	Transcriptional regulator
JMW49_RS14310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JMW49_RS14310	COG0674	pyruvate-flavodoxin oxidoreductase activity
JMW49_RS14330	COG0280	phosphate acetyltransferase
JMW49_RS14335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS14340	COG2223	nitrite transmembrane transporter activity
JMW49_RS14345	COG1115	amino acid carrier protein
JMW49_RS14355	COG1288	antiporter activity
JMW49_RS14365	COG2207	Transcriptional regulator
JMW49_RS14375	COG3732	PTS system glucitol sorbitol-specific
JMW49_RS14380	COG3711	transcriptional antiterminator
JMW49_RS14380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS14400	COG0517	IMP dehydrogenase activity
JMW49_RS14405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JMW49_RS14410	COG0574	Belongs to the PEP-utilizing enzyme family
JMW49_RS14410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JMW49_RS14440	COG0551	DNA topoisomerase type I activity
JMW49_RS14440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JMW49_RS14450	COG1388	LysM domain
JMW49_RS14450	COG3103	Sh3 type 3 domain protein
JMW49_RS14450	COG0791	NLP P60 protein
JMW49_RS14455	COG3546	catalase activity
JMW49_RS14470	COG0037	tRNA processing
JMW49_RS14490	COG2176	DNA-directed DNA polymerase activity
JMW49_RS14495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JMW49_RS14500	COG0072	phenylalanine-tRNA ligase activity
JMW49_RS14500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JMW49_RS14560	COG2203	Gaf domain
JMW49_RS14560	COG2199	diguanylate cyclase activity
JMW49_RS14565	COG2199	diguanylate cyclase activity
JMW49_RS14590	COG3426	butyrate kinase activity
JMW49_RS14595	COG2364	Membrane
JMW49_RS14605	COG0628	permease
JMW49_RS14620	COG1966	Carbon starvation protein
JMW49_RS14625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JMW49_RS14635	COG0157	Belongs to the NadC ModD family
JMW49_RS14675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JMW49_RS14680	COG1116	anion transmembrane transporter activity
JMW49_RS14695	COG0561	phosphatase activity
JMW49_RS14715	COG3118	belongs to the thioredoxin family
JMW49_RS14745	COG0006	proline dipeptidase activity
JMW49_RS14755	COG0583	DNA-binding transcription factor activity
JMW49_RS14760	COG0490	domain, Protein
JMW49_RS14760	COG0490	domain, Protein
JMW49_RS14760	COG2985	domain, Protein
JMW49_RS14760	COG2985	domain, Protein
JMW49_RS14765	COG0427	acetyl-CoA hydrolase
JMW49_RS14770	COG1012	belongs to the aldehyde dehydrogenase family
JMW49_RS14785	COG0427	acetyl-CoA hydrolase
JMW49_RS14790	COG1454	alcohol dehydrogenase
JMW49_RS14800	COG3853	Toxic anion resistance protein (TelA)
JMW49_RS14805	COG0516	GMP reductase activity
JMW49_RS14805	COG0517	IMP dehydrogenase activity
JMW49_RS14815	COG3711	transcriptional antiterminator
JMW49_RS14820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS14825	COG0246	Mannitol dehydrogenase
JMW49_RS14830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JMW49_RS14835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JMW49_RS14840	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JMW49_RS14840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JMW49_RS14850	COG3414	Phosphotransferase system galactitol-specific IIB component
JMW49_RS14855	COG3775	system Galactitol-specific IIC component
JMW49_RS14860	COG1063	alcohol dehydrogenase
JMW49_RS14870	COG3959	Transketolase, thiamine diphosphate binding domain
JMW49_RS14875	COG3958	Transketolase
JMW49_RS14880	COG0698	ribose 5-phosphate isomerase
JMW49_RS14885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JMW49_RS14890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JMW49_RS14940	COG3620	sequence-specific DNA binding
JMW49_RS14990	COG5002	protein histidine kinase activity
JMW49_RS15000	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JMW49_RS15005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JMW49_RS15025	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JMW49_RS15025	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JMW49_RS15030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS15030	COG2213	PTS system mannitol-specific
JMW49_RS15035	COG3414	Phosphotransferase system galactitol-specific IIB component
JMW49_RS15040	COG3775	system Galactitol-specific IIC component
JMW49_RS15045	COG1063	alcohol dehydrogenase
JMW49_RS15050	COG0235	Class ii aldolase
JMW49_RS15055	COG0235	Class ii aldolase
JMW49_RS15060	COG1115	amino acid carrier protein
JMW49_RS15080	COG2365	Tyrosine phosphatase family
JMW49_RS15085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS15085	COG3711	transcriptional antiterminator
JMW49_RS15090	COG1105	Belongs to the carbohydrate kinase PfkB family
JMW49_RS15095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JMW49_RS15095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS15095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JMW49_RS15105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JMW49_RS15105	COG0723	plastoquinol--plastocyanin reductase activity
JMW49_RS15120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JMW49_RS15125	COG3104	oligopeptide transport
JMW49_RS15130	COG0006	proline dipeptidase activity
JMW49_RS15135	COG3104	oligopeptide transport
JMW49_RS15140	COG0662	Cupin 2, conserved barrel domain protein
JMW49_RS15170	COG1509	lysine 2,3-aminomutase activity
JMW49_RS15185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JMW49_RS15195	COG1404	Belongs to the peptidase S8 family
JMW49_RS15210	COG0017	Asparaginyl-tRNA synthetase
JMW49_RS15215	COG3706	GGDEF domain
JMW49_RS15215	COG4251	negative regulation of phosphorylation
JMW49_RS15215	COG5001	Diguanylate cyclase
JMW49_RS15215	COG2203	Gaf domain
JMW49_RS15230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JMW49_RS15235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JMW49_RS15240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JMW49_RS15300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JMW49_RS15310	COG0710	3-dehydroquinate dehydratase activity
JMW49_RS15330	COG0288	reversible hydration of carbon dioxide
JMW49_RS15345	COG1132	(ABC) transporter
JMW49_RS15350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JMW49_RS15365	COG1012	belongs to the aldehyde dehydrogenase family
JMW49_RS15370	COG0628	permease
JMW49_RS15375	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JMW49_RS15380	COG1309	transcriptional regulator
JMW49_RS15395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JMW49_RS15405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JMW49_RS15405	COG0674	pyruvate-flavodoxin oxidoreductase activity
JMW49_RS15425	COG1528	Iron-storage protein
JMW49_RS15445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JMW49_RS15465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JMW49_RS15470	COG1554	hydrolase, family 65, central catalytic
JMW49_RS15475	COG1705	Flagellar rod assembly protein muramidase FlgJ
JMW49_RS15500	COG0596	Alpha beta hydrolase
JMW49_RS15505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JMW49_RS15510	COG0243	molybdopterin cofactor binding
JMW49_RS15515	COG0437	4 iron, 4 sulfur cluster binding
JMW49_RS15520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JMW49_RS15545	COG1126	abc transporter atp-binding protein
JMW49_RS15550	COG1301	dicarboxylic acid transport
JMW49_RS15570	COG1151	hydroxylamine reductase activity
JMW49_RS15580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JMW49_RS15580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JMW49_RS15595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JMW49_RS15635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JMW49_RS15640	COG1160	GTP binding
JMW49_RS15650	COG1363	Peptidase, m42
JMW49_RS15670	COG2720	vancomycin resistance protein
JMW49_RS15685	COG1193	negative regulation of DNA recombination
JMW49_RS15705	COG1686	Belongs to the peptidase S11 family
JMW49_RS15710	COG0052	Belongs to the universal ribosomal protein uS2 family
JMW49_RS15715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JMW49_RS15720	COG0528	UMP kinase activity
JMW49_RS15725	COG0233	cytoplasmic translational termination
JMW49_RS15740	COG4589	Belongs to the CDS family
JMW49_RS15795	COG1518	maintenance of DNA repeat elements
JMW49_RS15800	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JMW49_RS15810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JMW49_RS15815	COG0750	zinc metalloprotease
JMW49_RS15820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JMW49_RS15840	COG1247	-acetyltransferase
JMW49_RS15885	COG0492	ferredoxin-NADP+ reductase activity
JMW49_RS15890	COG1217	gtp-binding protein TYPA
JMW49_RS15905	COG2217	Heavy metal translocating P-type atpase
JMW49_RS15910	COG0745	RESPONSE REGULATOR receiver
JMW49_RS15915	COG5002	protein histidine kinase activity
JMW49_RS15925	COG1349	DNA-binding transcription factor activity
JMW49_RS15930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JMW49_RS15940	COG0534	Mate efflux family protein
JMW49_RS15945	COG2252	PERMEase
JMW49_RS15955	COG1131	(ABC) transporter
JMW49_RS15990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JMW49_RS15990	COG2080	2 iron, 2 sulfur cluster binding
JMW49_RS16000	COG4708	membrane
JMW49_RS16015	COG1401	restriction endodeoxyribonuclease activity
JMW49_RS16025	COG3829	transcription factor binding
JMW49_RS16050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JMW49_RS16075	COG0402	S-adenosylhomocysteine deaminase activity
JMW49_RS16095	COG0402	S-adenosylhomocysteine deaminase activity
JMW49_RS16100	COG0167	dihydroorotate dehydrogenase activity
JMW49_RS16110	COG2233	PERMEase
JMW49_RS16120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JMW49_RS16120	COG2080	2 iron, 2 sulfur cluster binding
JMW49_RS16130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JMW49_RS16145	COG0488	(ABC) transporter
JMW49_RS16155	COG0582	viral genome integration into host DNA
JMW49_RS16185	COG1597	lipid kinase activity
JMW49_RS16190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JMW49_RS16215	COG0527	aspartate kinase activity
JMW49_RS16220	COG0019	diaminopimelate decarboxylase activity
JMW49_RS16230	COG0628	permease
JMW49_RS16235	COG1187	pseudouridine synthase activity
JMW49_RS16240	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JMW49_RS16245	COG1737	Transcriptional regulator
JMW49_RS16265	COG3655	Transcriptional regulator
JMW49_RS16280	COG1309	transcriptional regulator
JMW49_RS16290	COG0456	acetyltransferase
JMW49_RS16300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JMW49_RS16305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JMW49_RS16310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JMW49_RS16315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JMW49_RS16325	COG1794	racemase activity, acting on amino acids and derivatives
JMW49_RS16350	COG1725	Transcriptional regulator
JMW49_RS16370	COG2814	Major facilitator Superfamily
JMW49_RS16375	COG2207	Transcriptional regulator
JMW49_RS16405	COG0129	dihydroxy-acid dehydratase activity
JMW49_RS16420	COG1404	Belongs to the peptidase S8 family
JMW49_RS16435	COG0789	Transcriptional regulator
JMW49_RS16440	COG1321	iron dependent repressor
JMW49_RS16445	COG2207	Transcriptional regulator
JMW49_RS16450	COG0730	response to heat
JMW49_RS16570	COG2247	cell wall binding repeat
JMW49_RS16570	COG0860	N-Acetylmuramoyl-L-alanine amidase
JMW49_RS16575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JMW49_RS16585	COG0494	nUDIX hydrolase
JMW49_RS16590	COG0384	phenazine biosynthesis protein PhzF
JMW49_RS16595	COG1733	regulation of RNA biosynthetic process
JMW49_RS16620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JMW49_RS16625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JMW49_RS16630	COG1116	anion transmembrane transporter activity
JMW49_RS16635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JMW49_RS16640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JMW49_RS16645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JMW49_RS16650	COG1923	regulation of RNA biosynthetic process
JMW49_RS16655	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JMW49_RS16660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JMW49_RS16675	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
JMW49_RS16680	COG1811	Na channel or pump
JMW49_RS16710	COG2264	protein methyltransferase activity
JMW49_RS16720	COG0577	efflux transmembrane transporter activity
JMW49_RS16720	COG1136	(ABC) transporter
JMW49_RS16725	COG5002	protein histidine kinase activity
JMW49_RS16730	COG0745	RESPONSE REGULATOR receiver
JMW49_RS16740	COG0745	RESPONSE REGULATOR receiver
JMW49_RS16745	COG2205	protein histidine kinase activity
JMW49_RS16750	COG0577	efflux transmembrane transporter activity
JMW49_RS16750	COG1136	(ABC) transporter
JMW49_RS16770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JMW49_RS16775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JMW49_RS16780	COG2205	protein histidine kinase activity
JMW49_RS16790	COG1136	(ABC) transporter
JMW49_RS16800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JMW49_RS16820	COG0511	ligase activity, forming carbon-carbon bonds
JMW49_RS16825	COG0439	Biotin carboxylase
JMW49_RS16830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JMW49_RS16835	COG0825	malonyl-CoA metabolic process
JMW49_RS16840	COG2359	stage V sporulation protein S
JMW49_RS16855	COG4974	Belongs to the 'phage' integrase family
JMW49_RS16860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JMW49_RS16880	COG1116	anion transmembrane transporter activity
JMW49_RS16900	COG4766	ethanolamine catabolic process
JMW49_RS16905	COG3192	ethanolamine utilization protein
JMW49_RS16915	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
JMW49_RS16925	COG4869	propanediol catabolic process
JMW49_RS16940	COG1454	alcohol dehydrogenase
JMW49_RS16940	COG1012	belongs to the aldehyde dehydrogenase family
JMW49_RS16955	COG4302	ethanolamine ammonia-lyase activity
JMW49_RS16960	COG4303	Ethanolamine ammonia lyase large subunit
JMW49_RS16965	COG4819	ethanolamine utilization protein
JMW49_RS17005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JMW49_RS17015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JMW49_RS17050	COG2131	deaminase
JMW49_RS17080	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
JMW49_RS17085	COG2226	methyltransferase
JMW49_RS17090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JMW49_RS17110	COG5002	protein histidine kinase activity
JMW49_RS17110	COG5001	Diguanylate cyclase
JMW49_RS17120	COG0287	Prephenate dehydrogenase
JMW49_RS17130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JMW49_RS17135	COG0077	Prephenate dehydratase
JMW49_RS17135	COG1605	Chorismate mutase
JMW49_RS17140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JMW49_RS17145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JMW49_RS17150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JMW49_RS17155	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JMW49_RS17160	COG0598	Magnesium transport protein CorA
JMW49_RS17170	COG2205	protein histidine kinase activity
JMW49_RS17175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JMW49_RS17180	COG1846	Transcriptional regulator
JMW49_RS17185	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JMW49_RS17200	COG3022	response to hydroperoxide
JMW49_RS17205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JMW49_RS17220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JMW49_RS17225	COG0204	Acyl-transferase
JMW49_RS17230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JMW49_RS17235	COG2081	HI0933 family
JMW49_RS17240	COG0406	alpha-ribazole phosphatase activity
JMW49_RS17270	COG2814	Major facilitator Superfamily
JMW49_RS17280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JMW49_RS17285	COG1621	beta-fructofuranosidase activity
JMW49_RS17295	COG1609	Transcriptional regulator
JMW49_RS17305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JMW49_RS17320	COG0583	DNA-binding transcription factor activity
JMW49_RS17325	COG0446	pyridine nucleotide-disulphide oxidoreductase
JMW49_RS17350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JMW49_RS17365	COG2323	membrane
JMW49_RS17375	COG0789	Transcriptional regulator
JMW49_RS17385	COG0137	argininosuccinate synthase activity
JMW49_RS17395	COG5002	protein histidine kinase activity
JMW49_RS17395	COG3850	Histidine kinase
JMW49_RS17410	COG0116	Belongs to the methyltransferase superfamily
JMW49_RS17415	COG1606	tRNA processing
JMW49_RS17425	COG1393	Belongs to the ArsC family
JMW49_RS17435	COG0765	amino acid transport
JMW49_RS17440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JMW49_RS17485	COG0494	nUDIX hydrolase
JMW49_RS17495	COG3326	Membrane
JMW49_RS17530	COG0242	peptide deformylase activity
JMW49_RS17555	COG1309	transcriptional regulator
JMW49_RS17570	COG1924	4 iron, 4 sulfur cluster binding
JMW49_RS17575	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
JMW49_RS17605	COG0786	glutamate:sodium symporter activity
JMW49_RS17640	COG2204	response regulator
JMW49_RS17645	COG5002	protein histidine kinase activity
JMW49_RS17650	COG2610	gluconate transmembrane transporter activity
JMW49_RS17655	COG1917	Cupin 2, conserved barrel domain protein
JMW49_RS17655	COG1396	sequence-specific DNA binding
JMW49_RS17660	COG1011	Hydrolase
JMW49_RS17670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JMW49_RS17675	COG5012	cobalamin binding
JMW49_RS17730	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
JMW49_RS17735	COG2207	Transcriptional regulator
JMW49_RS17740	COG1283	sodium-dependent phosphate transmembrane transporter activity
JMW49_RS17815	COG0315	cyclic pyranopterin monophosphate synthase activity
JMW49_RS17825	COG0521	Mo-molybdopterin cofactor biosynthetic process
JMW49_RS17830	COG0393	Putative heavy-metal-binding
JMW49_RS17865	COG2022	thiamine diphosphate biosynthetic process
JMW49_RS17885	COG0514	ATP-dependent DNA helicase (RecQ)
JMW49_RS17915	COG1115	amino acid carrier protein
JMW49_RS17945	COG3118	belongs to the thioredoxin family
JMW49_RS17950	COG5002	protein histidine kinase activity