locus-tag	class	description
C4E25_RS00010	COG0741	lytic transglycosylase activity
C4E25_RS00010	COG0791	NLP P60 protein
C4E25_RS00070	COG0405	Gamma-glutamyltransferase
C4E25_RS00085	COG0493	'glutamate synthase
C4E25_RS00085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E25_RS00095	COG1136	(ABC) transporter
C4E25_RS00100	COG0577	efflux transmembrane transporter activity
C4E25_RS00140	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4E25_RS00145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4E25_RS00150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E25_RS00155	COG0131	Imidazoleglycerol-phosphate dehydratase
C4E25_RS00160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4E25_RS00165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4E25_RS00170	COG0107	imidazoleglycerol-phosphate synthase activity
C4E25_RS00175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4E25_RS00175	COG0140	phosphoribosyl-ATP diphosphatase activity
C4E25_RS00180	COG0531	amino acid
C4E25_RS00195	COG1595	DNA-templated transcription, initiation
C4E25_RS00210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4E25_RS00225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4E25_RS00230	COG0028	Belongs to the TPP enzyme family
C4E25_RS00235	COG3546	catalase activity
C4E25_RS00240	COG1331	Highly conserved protein containing a thioredoxin domain
C4E25_RS00250	COG2267	carboxylic ester hydrolase activity
C4E25_RS00255	COG1136	(ABC) transporter
C4E25_RS00275	COG1388	LysM domain
C4E25_RS00275	COG3584	3D domain protein
C4E25_RS00285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E25_RS00290	COG1295	ribonuclease BN
C4E25_RS00295	COG5002	protein histidine kinase activity
C4E25_RS00300	COG0460	homoserine dehydrogenase
C4E25_RS00310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4E25_RS00315	COG0596	Alpha beta hydrolase
C4E25_RS00330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E25_RS00340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4E25_RS00345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4E25_RS00350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4E25_RS00355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4E25_RS00360	COG1045	serine acetyltransferase
C4E25_RS00370	COG0024	Methionine aminopeptidase
C4E25_RS00385	COG0351	phosphomethylpyrimidine kinase
C4E25_RS00390	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C4E25_RS00395	COG0352	thiamine-phosphate diphosphorylase activity
C4E25_RS00400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS00420	COG1725	Transcriptional regulator
C4E25_RS00425	COG1131	(ABC) transporter
C4E25_RS00450	COG0402	S-adenosylhomocysteine deaminase activity
C4E25_RS00460	COG4555	ABC transporter
C4E25_RS00465	COG1668	transmembrane transport
C4E25_RS00475	COG1725	Transcriptional regulator
C4E25_RS00480	COG1131	(ABC) transporter
C4E25_RS00495	COG0668	transmembrane transport
C4E25_RS00505	COG0426	domain, Protein
C4E25_RS00525	COG0367	asparagine synthase
C4E25_RS00530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4E25_RS00545	COG2310	stress, protein
C4E25_RS00560	COG3853	Toxic anion resistance protein (TelA)
C4E25_RS00590	COG5505	Protein of unknown function (DUF819)
C4E25_RS00600	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E25_RS00615	COG4607	ABC-type enterochelin transport system periplasmic component
C4E25_RS00620	COG2203	Gaf domain
C4E25_RS00620	COG5001	Diguanylate cyclase
C4E25_RS00620	COG4251	negative regulation of phosphorylation
C4E25_RS00620	COG3706	GGDEF domain
C4E25_RS00635	COG0095	Lipoate-protein ligase
C4E25_RS00640	COG1757	Na H antiporter
C4E25_RS00650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4E25_RS00655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4E25_RS00660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E25_RS00665	COG3123	guanosine phosphorylase activity
C4E25_RS00705	COG1396	sequence-specific DNA binding
C4E25_RS00730	COG1131	(ABC) transporter
C4E25_RS00740	COG0745	RESPONSE REGULATOR receiver
C4E25_RS00745	COG2205	protein histidine kinase activity
C4E25_RS00760	COG1733	regulation of RNA biosynthetic process
C4E25_RS00765	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C4E25_RS00825	COG0745	RESPONSE REGULATOR receiver
C4E25_RS00830	COG5002	protein histidine kinase activity
C4E25_RS00835	COG3118	belongs to the thioredoxin family
C4E25_RS00865	COG1115	amino acid carrier protein
C4E25_RS00880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4E25_RS00880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4E25_RS00895	COG0514	ATP-dependent DNA helicase (RecQ)
C4E25_RS00900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4E25_RS00915	COG2022	thiamine diphosphate biosynthetic process
C4E25_RS00930	COG1288	antiporter activity
C4E25_RS00950	COG0393	Putative heavy-metal-binding
C4E25_RS00955	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4E25_RS00965	COG0315	cyclic pyranopterin monophosphate synthase activity
C4E25_RS01050	COG2207	Transcriptional regulator
C4E25_RS01055	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C4E25_RS01115	COG5012	cobalamin binding
C4E25_RS01120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4E25_RS01130	COG1011	Hydrolase
C4E25_RS01135	COG1396	sequence-specific DNA binding
C4E25_RS01135	COG1917	Cupin 2, conserved barrel domain protein
C4E25_RS01140	COG2610	gluconate transmembrane transporter activity
C4E25_RS01145	COG5002	protein histidine kinase activity
C4E25_RS01150	COG2204	response regulator
C4E25_RS01185	COG0786	glutamate:sodium symporter activity
C4E25_RS01220	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C4E25_RS01225	COG1924	4 iron, 4 sulfur cluster binding
C4E25_RS01240	COG1309	transcriptional regulator
C4E25_RS01265	COG0242	peptide deformylase activity
C4E25_RS01300	COG3326	Membrane
C4E25_RS01315	COG0494	nUDIX hydrolase
C4E25_RS01365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E25_RS01370	COG0765	amino acid transport
C4E25_RS01380	COG1393	Belongs to the ArsC family
C4E25_RS01390	COG1606	tRNA processing
C4E25_RS01395	COG0116	Belongs to the methyltransferase superfamily
C4E25_RS01410	COG3850	Histidine kinase
C4E25_RS01410	COG5002	protein histidine kinase activity
C4E25_RS01420	COG0137	argininosuccinate synthase activity
C4E25_RS01430	COG0789	Transcriptional regulator
C4E25_RS01440	COG2323	membrane
C4E25_RS01480	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4E25_RS01485	COG0583	DNA-binding transcription factor activity
C4E25_RS01500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E25_RS01510	COG1609	Transcriptional regulator
C4E25_RS01520	COG1621	beta-fructofuranosidase activity
C4E25_RS01525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E25_RS01535	COG2814	Major facilitator Superfamily
C4E25_RS01565	COG0406	alpha-ribazole phosphatase activity
C4E25_RS01570	COG2081	HI0933 family
C4E25_RS01575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4E25_RS01580	COG0204	Acyl-transferase
C4E25_RS01585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4E25_RS01600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4E25_RS01605	COG3022	response to hydroperoxide
C4E25_RS01620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C4E25_RS01625	COG1846	Transcriptional regulator
C4E25_RS01630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E25_RS01635	COG2205	protein histidine kinase activity
C4E25_RS01645	COG0598	Magnesium transport protein CorA
C4E25_RS01655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4E25_RS01660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4E25_RS01665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4E25_RS01670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4E25_RS01675	COG0077	Prephenate dehydratase
C4E25_RS01675	COG1605	Chorismate mutase
C4E25_RS01680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4E25_RS01690	COG0287	Prephenate dehydrogenase
C4E25_RS01700	COG5001	Diguanylate cyclase
C4E25_RS01700	COG5002	protein histidine kinase activity
C4E25_RS01720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4E25_RS01725	COG2226	methyltransferase
C4E25_RS01730	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C4E25_RS01760	COG2131	deaminase
C4E25_RS01815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E25_RS01820	COG0582	viral genome integration into host DNA
C4E25_RS01825	COG1192	Involved in chromosome partitioning
C4E25_RS01830	COG1475	DNA binding
C4E25_RS01865	COG1484	DNA-dependent DNA replication
C4E25_RS01985	COG0358	DNA primase activity
C4E25_RS02030	COG1388	LysM domain
C4E25_RS02030	COG0791	NLP P60 protein
C4E25_RS02070	COG2003	Belongs to the UPF0758 family
C4E25_RS02080	COG0488	(ABC) transporter
C4E25_RS02085	COG4509	Sortase family
C4E25_RS02125	COG0596	Alpha beta hydrolase
C4E25_RS02170	COG0358	DNA primase activity
C4E25_RS02285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E25_RS02285	COG0551	DNA topoisomerase type I activity
C4E25_RS02305	COG3843	relaxase mobilization nuclease domain protein
C4E25_RS02325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4E25_RS02335	COG3843	relaxase mobilization nuclease domain protein
C4E25_RS02345	COG2315	Protein conserved in bacteria
C4E25_RS02360	COG3328	transposase activity
C4E25_RS02375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4E25_RS02380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4E25_RS02455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E25_RS02500	COG4819	ethanolamine utilization protein
C4E25_RS02505	COG4303	Ethanolamine ammonia lyase large subunit
C4E25_RS02510	COG4302	ethanolamine ammonia-lyase activity
C4E25_RS02525	COG1454	alcohol dehydrogenase
C4E25_RS02525	COG1012	belongs to the aldehyde dehydrogenase family
C4E25_RS02540	COG4869	propanediol catabolic process
C4E25_RS02550	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C4E25_RS02560	COG3192	ethanolamine utilization protein
C4E25_RS02565	COG4766	ethanolamine catabolic process
C4E25_RS02585	COG1116	anion transmembrane transporter activity
C4E25_RS02605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4E25_RS02610	COG4974	Belongs to the 'phage' integrase family
C4E25_RS02625	COG2359	stage V sporulation protein S
C4E25_RS02630	COG0825	malonyl-CoA metabolic process
C4E25_RS02635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4E25_RS02640	COG0439	Biotin carboxylase
C4E25_RS02645	COG0511	ligase activity, forming carbon-carbon bonds
C4E25_RS02665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4E25_RS02675	COG1136	(ABC) transporter
C4E25_RS02685	COG2205	protein histidine kinase activity
C4E25_RS02690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E25_RS02695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E25_RS02715	COG1136	(ABC) transporter
C4E25_RS02715	COG0577	efflux transmembrane transporter activity
C4E25_RS02720	COG2205	protein histidine kinase activity
C4E25_RS02725	COG0745	RESPONSE REGULATOR receiver
C4E25_RS02735	COG0745	RESPONSE REGULATOR receiver
C4E25_RS02740	COG5002	protein histidine kinase activity
C4E25_RS02745	COG1136	(ABC) transporter
C4E25_RS02745	COG0577	efflux transmembrane transporter activity
C4E25_RS02755	COG2264	protein methyltransferase activity
C4E25_RS02785	COG1811	Na channel or pump
C4E25_RS02790	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C4E25_RS02805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E25_RS02810	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C4E25_RS02815	COG1923	regulation of RNA biosynthetic process
C4E25_RS02820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4E25_RS02825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4E25_RS02830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4E25_RS02835	COG1116	anion transmembrane transporter activity
C4E25_RS02840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4E25_RS02845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E25_RS02865	COG1733	regulation of RNA biosynthetic process
C4E25_RS02870	COG0384	phenazine biosynthesis protein PhzF
C4E25_RS02875	COG0494	nUDIX hydrolase
C4E25_RS02890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E25_RS02895	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS02895	COG2247	cell wall binding repeat
C4E25_RS03045	COG0730	response to heat
C4E25_RS03050	COG2207	Transcriptional regulator
C4E25_RS03055	COG1321	iron dependent repressor
C4E25_RS03060	COG0789	Transcriptional regulator
C4E25_RS03075	COG1404	Belongs to the peptidase S8 family
C4E25_RS03090	COG0129	dihydroxy-acid dehydratase activity
C4E25_RS03120	COG2207	Transcriptional regulator
C4E25_RS03125	COG2814	Major facilitator Superfamily
C4E25_RS03145	COG1725	Transcriptional regulator
C4E25_RS03170	COG1794	racemase activity, acting on amino acids and derivatives
C4E25_RS03180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4E25_RS03185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4E25_RS03190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4E25_RS03195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4E25_RS03205	COG0456	acetyltransferase
C4E25_RS03215	COG1309	transcriptional regulator
C4E25_RS03235	COG3655	Transcriptional regulator
C4E25_RS03260	COG1737	Transcriptional regulator
C4E25_RS03265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C4E25_RS03270	COG1187	pseudouridine synthase activity
C4E25_RS03275	COG0628	permease
C4E25_RS03285	COG0019	diaminopimelate decarboxylase activity
C4E25_RS03290	COG0527	aspartate kinase activity
C4E25_RS03320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4E25_RS03325	COG1597	lipid kinase activity
C4E25_RS03355	COG0582	viral genome integration into host DNA
C4E25_RS03365	COG0488	(ABC) transporter
C4E25_RS03380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4E25_RS03390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E25_RS03390	COG2080	2 iron, 2 sulfur cluster binding
C4E25_RS03400	COG2233	PERMEase
C4E25_RS03415	COG0167	dihydroorotate dehydrogenase activity
C4E25_RS03420	COG0402	S-adenosylhomocysteine deaminase activity
C4E25_RS03440	COG0402	S-adenosylhomocysteine deaminase activity
C4E25_RS03465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E25_RS03490	COG3829	transcription factor binding
C4E25_RS03500	COG1401	restriction endodeoxyribonuclease activity
C4E25_RS03515	COG4708	membrane
C4E25_RS03525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E25_RS03525	COG2080	2 iron, 2 sulfur cluster binding
C4E25_RS03560	COG1131	(ABC) transporter
C4E25_RS03570	COG2252	PERMEase
C4E25_RS03575	COG0534	Mate efflux family protein
C4E25_RS03585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E25_RS03590	COG1349	DNA-binding transcription factor activity
C4E25_RS03600	COG5002	protein histidine kinase activity
C4E25_RS03605	COG0745	RESPONSE REGULATOR receiver
C4E25_RS03610	COG2217	Heavy metal translocating P-type atpase
C4E25_RS03625	COG1217	gtp-binding protein TYPA
C4E25_RS03630	COG0492	ferredoxin-NADP+ reductase activity
C4E25_RS03670	COG1247	-acetyltransferase
C4E25_RS03695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4E25_RS03700	COG0750	zinc metalloprotease
C4E25_RS03705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4E25_RS03715	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4E25_RS03720	COG1518	maintenance of DNA repeat elements
C4E25_RS03780	COG4589	Belongs to the CDS family
C4E25_RS03795	COG0233	cytoplasmic translational termination
C4E25_RS03800	COG0528	UMP kinase activity
C4E25_RS03805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4E25_RS03810	COG0052	Belongs to the universal ribosomal protein uS2 family
C4E25_RS03815	COG1686	Belongs to the peptidase S11 family
C4E25_RS03835	COG1193	negative regulation of DNA recombination
C4E25_RS03850	COG2720	vancomycin resistance protein
C4E25_RS03870	COG1363	Peptidase, m42
C4E25_RS03880	COG1160	GTP binding
C4E25_RS03885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4E25_RS03925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4E25_RS03940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4E25_RS03940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4E25_RS03950	COG1151	hydroxylamine reductase activity
C4E25_RS03970	COG1301	dicarboxylic acid transport
C4E25_RS03975	COG1126	abc transporter atp-binding protein
C4E25_RS04000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E25_RS04005	COG0437	4 iron, 4 sulfur cluster binding
C4E25_RS04010	COG0243	molybdopterin cofactor binding
C4E25_RS04015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4E25_RS04020	COG0596	Alpha beta hydrolase
C4E25_RS04045	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4E25_RS04050	COG1554	hydrolase, family 65, central catalytic
C4E25_RS04055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E25_RS04080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E25_RS04100	COG1528	Iron-storage protein
C4E25_RS04120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4E25_RS04120	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4E25_RS04130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E25_RS04145	COG1309	transcriptional regulator
C4E25_RS04150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4E25_RS04155	COG0628	permease
C4E25_RS04160	COG1012	belongs to the aldehyde dehydrogenase family
C4E25_RS04175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4E25_RS04180	COG1132	(ABC) transporter
C4E25_RS04200	COG0288	reversible hydration of carbon dioxide
C4E25_RS04220	COG0710	3-dehydroquinate dehydratase activity
C4E25_RS04230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E25_RS04290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4E25_RS04295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E25_RS04300	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4E25_RS04315	COG4251	negative regulation of phosphorylation
C4E25_RS04315	COG5001	Diguanylate cyclase
C4E25_RS04315	COG3706	GGDEF domain
C4E25_RS04315	COG2203	Gaf domain
C4E25_RS04320	COG0017	Asparaginyl-tRNA synthetase
C4E25_RS04335	COG1404	Belongs to the peptidase S8 family
C4E25_RS04345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E25_RS04360	COG1509	lysine 2,3-aminomutase activity
C4E25_RS04390	COG0662	Cupin 2, conserved barrel domain protein
C4E25_RS04395	COG3104	oligopeptide transport
C4E25_RS04400	COG0006	proline dipeptidase activity
C4E25_RS04405	COG3104	oligopeptide transport
C4E25_RS04410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E25_RS04425	COG0723	plastoquinol--plastocyanin reductase activity
C4E25_RS04425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4E25_RS04435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS04435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS04435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS04440	COG1105	Belongs to the carbohydrate kinase PfkB family
C4E25_RS04445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS04445	COG3711	transcriptional antiterminator
C4E25_RS04450	COG2365	Tyrosine phosphatase family
C4E25_RS04470	COG1115	amino acid carrier protein
C4E25_RS04475	COG0235	Class ii aldolase
C4E25_RS04480	COG0235	Class ii aldolase
C4E25_RS04485	COG1063	alcohol dehydrogenase
C4E25_RS04490	COG3775	system Galactitol-specific IIC component
C4E25_RS04495	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E25_RS04500	COG2213	PTS system mannitol-specific
C4E25_RS04500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS04505	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E25_RS04505	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E25_RS04525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS04530	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4E25_RS04540	COG5002	protein histidine kinase activity
C4E25_RS04600	COG3620	sequence-specific DNA binding
C4E25_RS04650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E25_RS04655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E25_RS04660	COG0698	ribose 5-phosphate isomerase
C4E25_RS04665	COG3958	Transketolase
C4E25_RS04670	COG3959	Transketolase, thiamine diphosphate binding domain
C4E25_RS04680	COG1063	alcohol dehydrogenase
C4E25_RS04685	COG3775	system Galactitol-specific IIC component
C4E25_RS04690	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E25_RS04700	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E25_RS04700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E25_RS04705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E25_RS04710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4E25_RS04715	COG0246	Mannitol dehydrogenase
C4E25_RS04720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS04725	COG3711	transcriptional antiterminator
C4E25_RS04735	COG0516	GMP reductase activity
C4E25_RS04735	COG0517	IMP dehydrogenase activity
C4E25_RS04740	COG3853	Toxic anion resistance protein (TelA)
C4E25_RS04750	COG1454	alcohol dehydrogenase
C4E25_RS04755	COG0427	acetyl-CoA hydrolase
C4E25_RS04770	COG1012	belongs to the aldehyde dehydrogenase family
C4E25_RS04775	COG0427	acetyl-CoA hydrolase
C4E25_RS04780	COG2985	domain, Protein
C4E25_RS04780	COG2985	domain, Protein
C4E25_RS04780	COG0490	domain, Protein
C4E25_RS04780	COG0490	domain, Protein
C4E25_RS04785	COG0583	DNA-binding transcription factor activity
C4E25_RS04795	COG0006	proline dipeptidase activity
C4E25_RS04825	COG3118	belongs to the thioredoxin family
C4E25_RS04845	COG0561	phosphatase activity
C4E25_RS04860	COG1116	anion transmembrane transporter activity
C4E25_RS04870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E25_RS04910	COG0157	Belongs to the NadC ModD family
C4E25_RS04920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4E25_RS04925	COG1966	Carbon starvation protein
C4E25_RS04940	COG0628	permease
C4E25_RS04950	COG2364	Membrane
C4E25_RS04955	COG3426	butyrate kinase activity
C4E25_RS04980	COG2199	diguanylate cyclase activity
C4E25_RS04985	COG2199	diguanylate cyclase activity
C4E25_RS04985	COG2203	Gaf domain
C4E25_RS05045	COG0072	phenylalanine-tRNA ligase activity
C4E25_RS05045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E25_RS05055	COG2176	DNA-directed DNA polymerase activity
C4E25_RS05075	COG0037	tRNA processing
C4E25_RS05090	COG3546	catalase activity
C4E25_RS05095	COG0791	NLP P60 protein
C4E25_RS05095	COG1388	LysM domain
C4E25_RS05095	COG3103	Sh3 type 3 domain protein
C4E25_RS05105	COG0551	DNA topoisomerase type I activity
C4E25_RS05105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E25_RS05135	COG0574	Belongs to the PEP-utilizing enzyme family
C4E25_RS05135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4E25_RS05140	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4E25_RS05145	COG0517	IMP dehydrogenase activity
C4E25_RS05165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS05165	COG3711	transcriptional antiterminator
C4E25_RS05180	COG2207	Transcriptional regulator
C4E25_RS05190	COG1288	antiporter activity
C4E25_RS05200	COG1115	amino acid carrier protein
C4E25_RS05205	COG2223	nitrite transmembrane transporter activity
C4E25_RS05210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS05215	COG0280	phosphate acetyltransferase
C4E25_RS05235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4E25_RS05235	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4E25_RS05245	COG1414	Transcriptional regulator
C4E25_RS05255	COG0751	glycine-tRNA ligase activity
C4E25_RS05260	COG0752	glycyl-tRNA synthetase alpha subunit
C4E25_RS05270	COG1381	Involved in DNA repair and RecF pathway recombination
C4E25_RS05280	COG2239	Acts as a magnesium transporter
C4E25_RS05285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4E25_RS05290	COG0295	cytidine deaminase activity
C4E25_RS05295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4E25_RS05300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4E25_RS05305	COG1702	phosphate starvation-inducible protein PhoH
C4E25_RS05320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4E25_RS05325	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4E25_RS05330	COG1610	YqeY-like protein
C4E25_RS05335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4E25_RS05340	COG0537	adenosine 5'-monophosphoramidase activity
C4E25_RS05345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E25_RS05350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4E25_RS05355	COG2264	protein methyltransferase activity
C4E25_RS05400	COG1674	ftsk spoiiie
C4E25_RS05410	COG2946	Replication initiation factor
C4E25_RS05440	COG0741	lytic transglycosylase activity
C4E25_RS05440	COG0791	NLP P60 protein
C4E25_RS05500	COG3842	ATPase activity
C4E25_RS05505	COG2508	Transcriptional regulator
C4E25_RS05510	COG0477	Major facilitator Superfamily
C4E25_RS05525	COG0484	heat shock protein binding
C4E25_RS05530	COG0443	Heat shock 70 kDa protein
C4E25_RS05535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4E25_RS05540	COG1420	regulation of RNA biosynthetic process
C4E25_RS05545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4E25_RS05550	COG0531	amino acid
C4E25_RS05555	COG0617	tRNA 3'-terminal CCA addition
C4E25_RS05560	COG0481	GTPase activity
C4E25_RS05585	COG0268	Binds directly to 16S ribosomal RNA
C4E25_RS05595	COG2333	competence protein COMEC
C4E25_RS05595	COG0658	competence protein
C4E25_RS05610	COG0658	competence protein
C4E25_RS05610	COG2333	competence protein COMEC
C4E25_RS05615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4E25_RS05620	COG3584	3D domain protein
C4E25_RS05620	COG1388	LysM domain
C4E25_RS05625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4E25_RS05645	COG1396	sequence-specific DNA binding
C4E25_RS05650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E25_RS05655	COG0006	proline dipeptidase activity
C4E25_RS05660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS05665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS05675	COG3711	transcriptional antiterminator
C4E25_RS05675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS05680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E25_RS05685	COG1482	cell wall glycoprotein biosynthetic process
C4E25_RS05690	COG5002	protein histidine kinase activity
C4E25_RS05715	COG1686	Belongs to the peptidase S11 family
C4E25_RS05725	COG0165	Argininosuccinate lyase
C4E25_RS05730	COG0561	phosphatase activity
C4E25_RS05735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E25_RS05740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E25_RS05745	COG1876	peptidase activity
C4E25_RS05750	COG1309	transcriptional regulator
C4E25_RS05755	COG2814	Major facilitator Superfamily
C4E25_RS05775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS05775	COG1263	PTS System
C4E25_RS05780	COG3711	transcriptional antiterminator
C4E25_RS05785	COG2190	(PTS) system
C4E25_RS05785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS05785	COG1263	PTS System
C4E25_RS05790	COG0251	oxidation-reduction process
C4E25_RS05795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4E25_RS05835	COG0495	leucyl-tRNA aminoacylation
C4E25_RS05840	COG0799	negative regulation of ribosome biogenesis
C4E25_RS05845	COG1713	HD superfamily hydrolase involved in NAD metabolism
C4E25_RS05850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4E25_RS05855	COG2137	regulation of response to DNA damage stimulus
C4E25_RS05860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4E25_RS05865	COG1309	transcriptional regulator
C4E25_RS05915	COG1136	(ABC) transporter
C4E25_RS05915	COG0577	efflux transmembrane transporter activity
C4E25_RS05925	COG0745	RESPONSE REGULATOR receiver
C4E25_RS05930	COG0737	Belongs to the 5'-nucleotidase family
C4E25_RS05940	COG1234	tRNA 3'-trailer cleavage
C4E25_RS05945	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4E25_RS05975	COG4124	Belongs to the glycosyl hydrolase 26 family
C4E25_RS05975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C4E25_RS05995	COG0395	ABC-type sugar transport system, permease component
C4E25_RS06020	COG0742	ribosomal rna small subunit methyltransferase
C4E25_RS06025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4E25_RS06030	COG1461	Dihydroxyacetone kinase
C4E25_RS06035	COG1302	Protein conserved in bacteria
C4E25_RS06040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4E25_RS06055	COG0789	Transcriptional regulator
C4E25_RS06060	COG3711	transcriptional antiterminator
C4E25_RS06060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS06065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS06065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS06065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS06070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS06070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS06070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS06075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS06080	COG0383	alpha-mannosidase activity
C4E25_RS06085	COG5002	protein histidine kinase activity
C4E25_RS06105	COG1564	THIamine pyrophosphokinase
C4E25_RS06110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E25_RS06115	COG1162	GTPase activity
C4E25_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
C4E25_RS06125	COG0515	serine threonine protein kinase
C4E25_RS06125	COG2815	serine threonine protein kinase
C4E25_RS06135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4E25_RS06140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4E25_RS06140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4E25_RS06145	COG2738	Putative neutral zinc metallopeptidase
C4E25_RS06155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4E25_RS06160	COG0242	peptide deformylase activity
C4E25_RS06165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4E25_RS06170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4E25_RS06175	COG1758	RNA polymerase activity
C4E25_RS06180	COG0194	GDP metabolic process
C4E25_RS06185	COG1561	YicC-like family, N-terminal region
C4E25_RS06190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4E25_RS06200	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C4E25_RS06205	COG0488	(ABC) transporter
C4E25_RS06215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4E25_RS06220	COG0564	pseudouridine synthase activity
C4E25_RS06225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4E25_RS06235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4E25_RS06240	COG1966	Carbon starvation protein
C4E25_RS06245	COG3279	Response regulator of the LytR AlgR family
C4E25_RS06250	COG3275	phosphorelay sensor kinase activity
C4E25_RS06275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4E25_RS06280	COG0531	amino acid
C4E25_RS06285	COG0006	proline dipeptidase activity
C4E25_RS06290	COG1307	EDD domain protein, DegV family
C4E25_RS06305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E25_RS06310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4E25_RS06320	COG2302	S4 RNA-binding domain
C4E25_RS06330	COG1799	cell septum assembly
C4E25_RS06335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4E25_RS06355	COG3830	Belongs to the UPF0237 family
C4E25_RS06365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C4E25_RS06380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4E25_RS06385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4E25_RS06390	COG1160	GTP binding
C4E25_RS06415	COG5002	protein histidine kinase activity
C4E25_RS06420	COG0745	RESPONSE REGULATOR receiver
C4E25_RS06430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4E25_RS06435	COG1873	PFAM PRC-barrel domain
C4E25_RS06440	COG1191	sigma factor activity
C4E25_RS06445	COG1191	sigma factor activity
C4E25_RS06460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4E25_RS06465	COG3856	small basic protein
C4E25_RS06485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E25_RS06490	COG0772	Belongs to the SEDS family
C4E25_RS06495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4E25_RS06500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4E25_RS06505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4E25_RS06510	COG0768	penicillin binding
C4E25_RS06520	COG0275	rRNA processing
C4E25_RS06525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4E25_RS06530	COG0612	Peptidase, M16
C4E25_RS06540	COG0012	GTP binding
C4E25_RS06545	COG3300	MHYT domain
C4E25_RS06545	COG5001	Diguanylate cyclase
C4E25_RS06550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4E25_RS06560	COG2190	(PTS) system
C4E25_RS06570	COG3711	transcriptional antiterminator
C4E25_RS06575	COG0025	NhaP-type Na H and K H
C4E25_RS06580	COG4608	Belongs to the ABC transporter superfamily
C4E25_RS06585	COG0444	Belongs to the ABC transporter superfamily
C4E25_RS06595	COG0601	transmembrane transport
C4E25_RS06600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E25_RS06605	COG0583	DNA-binding transcription factor activity
C4E25_RS06610	COG0183	Belongs to the thiolase family
C4E25_RS06615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4E25_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
C4E25_RS06630	COG2610	gluconate transmembrane transporter activity
C4E25_RS06635	COG2340	Cysteine-rich secretory protein family
C4E25_RS06645	COG4869	propanediol catabolic process
C4E25_RS06680	COG2081	HI0933 family
C4E25_RS06685	COG0671	phosphoesterase, PA-phosphatase related
C4E25_RS06695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E25_RS06730	COG1388	LysM domain
C4E25_RS06730	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS06755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E25_RS06795	COG2252	PERMEase
C4E25_RS06800	COG0402	S-adenosylhomocysteine deaminase activity
C4E25_RS06810	COG2271	Major facilitator Superfamily
C4E25_RS06830	COG0583	DNA-binding transcription factor activity
C4E25_RS06840	COG1376	ErfK ybiS ycfS ynhG family protein
C4E25_RS06845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4E25_RS06850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4E25_RS06875	COG4509	Sortase family
C4E25_RS06895	COG0726	polysaccharide deacetylase
C4E25_RS06900	COG3069	C4-dicarboxylate transmembrane transporter activity
C4E25_RS06905	COG5002	protein histidine kinase activity
C4E25_RS06905	COG0642	Histidine kinase
C4E25_RS06910	COG0745	RESPONSE REGULATOR receiver
C4E25_RS06925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E25_RS06930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4E25_RS06950	COG1937	Protein conserved in bacteria
C4E25_RS06985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E25_RS06990	COG1757	Na H antiporter
C4E25_RS07000	COG2247	cell wall binding repeat
C4E25_RS07000	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS07005	COG0583	DNA-binding transcription factor activity
C4E25_RS07010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4E25_RS07020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4E25_RS07025	COG0124	histidyl-tRNA synthetase
C4E25_RS07030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4E25_RS07035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4E25_RS07040	COG1490	D-aminoacyl-tRNA deacylase activity
C4E25_RS07050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4E25_RS07055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4E25_RS07055	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4E25_RS07100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS07125	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS07130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4E25_RS07140	COG0561	phosphatase activity
C4E25_RS07145	COG1316	TRANSCRIPTIONal
C4E25_RS07150	COG1316	TRANSCRIPTIONal
C4E25_RS07155	COG1649	PFAM Uncharacterised BCR, COG1649
C4E25_RS07160	COG0791	NLP P60 protein
C4E25_RS07170	COG0438	transferase activity, transferring glycosyl groups
C4E25_RS07175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C4E25_RS07180	COG1215	transferase activity, transferring glycosyl groups
C4E25_RS07190	COG1215	transferase activity, transferring glycosyl groups
C4E25_RS07195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4E25_RS07195	COG1215	transferase activity, transferring glycosyl groups
C4E25_RS07200	COG1216	Glycosyl transferase, family 2
C4E25_RS07220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E25_RS07225	COG0728	peptidoglycan biosynthetic process
C4E25_RS07230	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS07230	COG2247	cell wall binding repeat
C4E25_RS07235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4E25_RS07240	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS07255	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS07255	COG2247	cell wall binding repeat
C4E25_RS07265	COG2246	polysaccharide biosynthetic process
C4E25_RS07270	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS07270	COG2247	cell wall binding repeat
C4E25_RS07285	COG0653	protein targeting
C4E25_RS07310	COG2247	cell wall binding repeat
C4E25_RS07310	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS07330	COG0343	queuine tRNA-ribosyltransferase activity
C4E25_RS07340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4E25_RS07345	COG2255	four-way junction helicase activity
C4E25_RS07350	COG0632	four-way junction helicase activity
C4E25_RS07355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4E25_RS07395	COG2610	gluconate transmembrane transporter activity
C4E25_RS07400	COG2084	Dehydrogenase
C4E25_RS07420	COG1132	(ABC) transporter
C4E25_RS07465	COG0436	Aminotransferase
C4E25_RS07470	COG0697	spore germination
C4E25_RS07485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4E25_RS07500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4E25_RS07505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4E25_RS07510	COG1473	amidohydrolase
C4E25_RS07515	COG3949	Membrane
C4E25_RS07530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4E25_RS07545	COG0604	alcohol dehydrogenase
C4E25_RS07555	COG1592	Rubrerythrin
C4E25_RS07560	COG0789	Transcriptional regulator
C4E25_RS07570	COG1664	Polymer-forming cytoskeletal
C4E25_RS07575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E25_RS07575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4E25_RS07580	COG1349	DNA-binding transcription factor activity
C4E25_RS07585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4E25_RS07590	COG1696	Membrane protein involved in D-alanine export
C4E25_RS07595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4E25_RS07605	COG0673	inositol 2-dehydrogenase activity
C4E25_RS07615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E25_RS07620	COG1253	flavin adenine dinucleotide binding
C4E25_RS07625	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4E25_RS07645	COG3290	protein histidine kinase activity
C4E25_RS07645	COG3829	transcription factor binding
C4E25_RS07650	COG2267	carboxylic ester hydrolase activity
C4E25_RS07660	COG0312	modulator of DNA gyrase
C4E25_RS07665	COG0312	modulator of DNA gyrase
C4E25_RS07705	COG1120	ATPase activity
C4E25_RS07710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E25_RS07715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E25_RS07730	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E25_RS07735	COG3394	polysaccharide catabolic process
C4E25_RS07740	COG1486	melibiose metabolic process
C4E25_RS07745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS07755	COG2188	Transcriptional regulator
C4E25_RS07760	COG0366	Alpha amylase catalytic
C4E25_RS07765	COG1263	PTS System
C4E25_RS07765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS07775	COG2188	Transcriptional regulator
C4E25_RS07780	COG1178	ABC-type Fe3 transport system permease component
C4E25_RS07785	COG3842	ATPase activity
C4E25_RS07790	COG1840	ABC-type Fe3 transport system, periplasmic component
C4E25_RS07795	COG1394	ATPase activity, coupled to movement of substances
C4E25_RS07800	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C4E25_RS07805	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C4E25_RS07820	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C4E25_RS07825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4E25_RS07830	COG1269	ATP hydrolysis coupled proton transport
C4E25_RS07855	COG3300	MHYT domain
C4E25_RS07855	COG5001	Diguanylate cyclase
C4E25_RS07860	COG1454	alcohol dehydrogenase
C4E25_RS07860	COG1012	belongs to the aldehyde dehydrogenase family
C4E25_RS07870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4E25_RS07880	COG0318	PFAM AMP-dependent synthetase and ligase
C4E25_RS07890	COG1268	BioY protein
C4E25_RS07905	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4E25_RS07920	COG1203	CRISPR-associated helicase, Cas3
C4E25_RS07950	COG0577	efflux transmembrane transporter activity
C4E25_RS07955	COG1136	(ABC) transporter
C4E25_RS07960	COG1968	undecaprenyl-diphosphatase activity
C4E25_RS07965	COG2205	protein histidine kinase activity
C4E25_RS07970	COG0745	RESPONSE REGULATOR receiver
C4E25_RS07985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E25_RS08010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E25_RS08015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E25_RS08025	COG1120	ATPase activity
C4E25_RS08030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E25_RS08040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E25_RS08045	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4E25_RS08070	COG1454	alcohol dehydrogenase
C4E25_RS08075	COG1376	ErfK ybiS ycfS ynhG family protein
C4E25_RS08085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E25_RS08090	COG0785	Cytochrome C biogenesis protein
C4E25_RS08095	COG1733	regulation of RNA biosynthetic process
C4E25_RS08100	COG0383	alpha-mannosidase activity
C4E25_RS08105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS08115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS08120	COG3711	transcriptional antiterminator
C4E25_RS08125	COG4975	Glucose uptake
C4E25_RS08145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4E25_RS08170	COG5002	protein histidine kinase activity
C4E25_RS08180	COG0492	ferredoxin-NADP+ reductase activity
C4E25_RS08185	COG3118	belongs to the thioredoxin family
C4E25_RS08195	COG0384	phenazine biosynthesis protein PhzF
C4E25_RS08215	COG0542	response to heat
C4E25_RS08235	COG2267	carboxylic ester hydrolase activity
C4E25_RS08250	COG1737	Transcriptional regulator
C4E25_RS08270	COG2971	BadF BadG BcrA BcrD
C4E25_RS08275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4E25_RS08285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS08300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4E25_RS08310	COG0642	Histidine kinase
C4E25_RS08325	COG1136	(ABC) transporter
C4E25_RS08335	COG2190	(PTS) system
C4E25_RS08350	COG1263	PTS System
C4E25_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08370	COG1070	Carbohydrate kinase
C4E25_RS08375	COG1940	carbohydrate kinase activity
C4E25_RS08385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS08390	COG3716	PTS system mannose fructose sorbose family IID component
C4E25_RS08415	COG0366	Alpha amylase catalytic
C4E25_RS08420	COG0191	fructose-bisphosphate aldolase activity
C4E25_RS08425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS08425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08450	COG3394	polysaccharide catabolic process
C4E25_RS08455	COG1263	PTS System
C4E25_RS08455	COG2190	(PTS) system
C4E25_RS08455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08460	COG2188	Transcriptional regulator
C4E25_RS08465	COG0366	Alpha amylase catalytic
C4E25_RS08475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4E25_RS08485	COG2723	6-phospho-beta-galactosidase activity
C4E25_RS08490	COG2723	6-phospho-beta-galactosidase activity
C4E25_RS08495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08495	COG2190	(PTS) system
C4E25_RS08495	COG1263	PTS System
C4E25_RS08500	COG3711	transcriptional antiterminator
C4E25_RS08510	COG1288	antiporter activity
C4E25_RS08515	COG2190	(PTS) system
C4E25_RS08515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08515	COG1263	PTS System
C4E25_RS08520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E25_RS08530	COG1132	(ABC) transporter
C4E25_RS08535	COG1136	(ABC) transporter
C4E25_RS08560	COG0745	RESPONSE REGULATOR receiver
C4E25_RS08565	COG2190	(PTS) system
C4E25_RS08570	COG0561	phosphatase activity
C4E25_RS08575	COG1454	alcohol dehydrogenase
C4E25_RS08580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E25_RS08585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS08585	COG3711	transcriptional antiterminator
C4E25_RS08590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E25_RS08595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E25_RS08600	COG0205	6-phosphofructokinase activity
C4E25_RS08625	COG1959	2 iron, 2 sulfur cluster binding
C4E25_RS08635	COG2723	6-phospho-beta-galactosidase activity
C4E25_RS08640	COG1263	PTS System
C4E25_RS08640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08640	COG2190	(PTS) system
C4E25_RS08650	COG1136	(ABC) transporter
C4E25_RS08675	COG1819	glycosyl
C4E25_RS08680	COG3620	sequence-specific DNA binding
C4E25_RS08690	COG2223	nitrite transmembrane transporter activity
C4E25_RS08695	COG1695	Transcriptional regulator
C4E25_RS08705	COG0640	Transcriptional regulator
C4E25_RS08715	COG2723	6-phospho-beta-galactosidase activity
C4E25_RS08720	COG2190	(PTS) system
C4E25_RS08720	COG1263	PTS System
C4E25_RS08720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08725	COG3711	transcriptional antiterminator
C4E25_RS08735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS08735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS08740	COG3711	transcriptional antiterminator
C4E25_RS08750	COG0191	fructose-bisphosphate aldolase activity
C4E25_RS08755	COG1178	ABC-type Fe3 transport system permease component
C4E25_RS08760	COG3842	ATPase activity
C4E25_RS08770	COG1840	ABC-type Fe3 transport system, periplasmic component
C4E25_RS08775	COG2723	6-phospho-beta-galactosidase activity
C4E25_RS08780	COG2190	(PTS) system
C4E25_RS08780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS08780	COG1263	PTS System
C4E25_RS08785	COG3711	transcriptional antiterminator
C4E25_RS08810	COG0693	protein deglycase activity
C4E25_RS08865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4E25_RS08895	COG0557	exoribonuclease II activity
C4E25_RS08910	COG1881	PFAM PEBP family protein
C4E25_RS08940	COG0148	phosphopyruvate hydratase activity
C4E25_RS08945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4E25_RS08950	COG0149	triose-phosphate isomerase activity
C4E25_RS08955	COG0126	phosphoglycerate kinase activity
C4E25_RS08965	COG2390	Transcriptional regulator
C4E25_RS08970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4E25_RS08975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E25_RS08985	COG0167	dihydroorotate dehydrogenase activity
C4E25_RS08995	COG0402	S-adenosylhomocysteine deaminase activity
C4E25_RS09000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4E25_RS09015	COG3829	transcription factor binding
C4E25_RS09020	COG0251	oxidation-reduction process
C4E25_RS09035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4E25_RS09040	COG0789	Transcriptional regulator
C4E25_RS09065	COG2247	cell wall binding repeat
C4E25_RS09065	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS09070	COG1136	(ABC) transporter
C4E25_RS09075	COG0577	efflux transmembrane transporter activity
C4E25_RS09100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4E25_RS09110	COG0789	Transcriptional regulator
C4E25_RS09135	COG2205	protein histidine kinase activity
C4E25_RS09135	COG2770	Histidine kinase
C4E25_RS09140	COG0745	RESPONSE REGULATOR receiver
C4E25_RS09145	COG0706	membrane insertase activity
C4E25_RS09155	COG0778	Nitroreductase
C4E25_RS09165	COG0534	Mate efflux family protein
C4E25_RS09200	COG1732	Glycine betaine
C4E25_RS09205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4E25_RS09215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4E25_RS09230	COG1473	amidohydrolase
C4E25_RS09235	COG1760	l-serine dehydratase
C4E25_RS09240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E25_RS09245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4E25_RS09250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E25_RS09255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4E25_RS09260	COG2171	N-acyltransferase activity
C4E25_RS09270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4E25_RS09280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4E25_RS09285	COG3681	Belongs to the UPF0597 family
C4E25_RS09295	COG3829	transcription factor binding
C4E25_RS09300	COG2226	methyltransferase
C4E25_RS09325	COG5275	peptidyl-tyrosine sulfation
C4E25_RS09325	COG0252	asparaginase activity
C4E25_RS09330	COG0252	asparaginase activity
C4E25_RS09330	COG5275	peptidyl-tyrosine sulfation
C4E25_RS09345	COG5275	peptidyl-tyrosine sulfation
C4E25_RS09345	COG0252	asparaginase activity
C4E25_RS09365	COG4656	Part of a membrane complex involved in electron transport
C4E25_RS09375	COG0726	polysaccharide deacetylase
C4E25_RS09400	COG0285	dihydrofolate synthase activity
C4E25_RS09410	COG3279	Response regulator of the LytR AlgR family
C4E25_RS09415	COG0525	valine-tRNA ligase activity
C4E25_RS09425	COG0726	polysaccharide deacetylase
C4E25_RS09440	COG0704	Plays a role in the regulation of phosphate uptake
C4E25_RS09445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4E25_RS09450	COG0581	inorganic phosphate transmembrane transporter activity
C4E25_RS09455	COG0573	inorganic phosphate transmembrane transporter activity
C4E25_RS09475	COG0745	RESPONSE REGULATOR receiver
C4E25_RS09480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4E25_RS09485	COG1164	Oligoendopeptidase f
C4E25_RS09490	COG1285	pathogenesis
C4E25_RS09515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4E25_RS09520	COG3716	PTS system mannose fructose sorbose family IID component
C4E25_RS09525	COG3715	PTS system
C4E25_RS09530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS09530	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS09535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS09535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS09545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4E25_RS09560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4E25_RS09565	COG0166	Belongs to the GPI family
C4E25_RS09575	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4E25_RS09590	COG3012	SEC-C Motif Domain Protein
C4E25_RS09590	COG1405	negative regulation of cell septum assembly
C4E25_RS09615	COG1459	type II secretion system
C4E25_RS09620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4E25_RS09635	COG2814	Major facilitator Superfamily
C4E25_RS09640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4E25_RS09645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4E25_RS09655	COG2059	Chromate
C4E25_RS09660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4E25_RS09665	COG0740	serine-type endopeptidase activity
C4E25_RS09670	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4E25_RS09685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4E25_RS09740	COG2946	Replication initiation factor
C4E25_RS09760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E25_RS09760	COG0493	'glutamate synthase
C4E25_RS09770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E25_RS09780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4E25_RS09840	COG0457	Tetratricopeptide repeat
C4E25_RS09840	COG0463	Glycosyl transferase, family 2
C4E25_RS09855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS09865	COG0778	Nitroreductase
C4E25_RS09870	COG1733	regulation of RNA biosynthetic process
C4E25_RS09885	COG0488	(ABC) transporter
C4E25_RS09890	COG0745	RESPONSE REGULATOR receiver
C4E25_RS09910	COG4555	ABC transporter
C4E25_RS09915	COG2199	diguanylate cyclase activity
C4E25_RS09960	COG0205	6-phosphofructokinase activity
C4E25_RS09970	COG1481	regulation of sporulation
C4E25_RS09985	COG1660	Displays ATPase and GTPase activities
C4E25_RS09995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4E25_RS10000	COG2116	formate transmembrane transporter activity
C4E25_RS10005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4E25_RS10035	COG0322	excinuclease ABC activity
C4E25_RS10045	COG0556	nucleotide-excision repair
C4E25_RS10055	COG1653	transport
C4E25_RS10065	COG1175	transmembrane transport
C4E25_RS10070	COG3842	ATPase activity
C4E25_RS10090	COG1648	precorrin-2 dehydrogenase activity
C4E25_RS10090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4E25_RS10095	COG0113	porphobilinogen synthase activity
C4E25_RS10105	COG0181	hydroxymethylbilane synthase activity
C4E25_RS10145	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4E25_RS10160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E25_RS10170	COG1797	cobyrinic acid a,c-diamide synthase activity
C4E25_RS10175	COG1492	cobalamin metabolic process
C4E25_RS10185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4E25_RS10195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4E25_RS10215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E25_RS10230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS10235	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E25_RS10240	COG1363	Peptidase, m42
C4E25_RS10245	COG3711	transcriptional antiterminator
C4E25_RS10250	COG0191	fructose-bisphosphate aldolase activity
C4E25_RS10255	COG2222	sugar isomerase
C4E25_RS10260	COG0673	inositol 2-dehydrogenase activity
C4E25_RS10270	COG2188	Transcriptional regulator
C4E25_RS10280	COG3409	Peptidoglycan-binding domain 1 protein
C4E25_RS10280	COG0793	Belongs to the peptidase S41A family
C4E25_RS10285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4E25_RS10295	COG3949	Membrane
C4E25_RS10300	COG3958	Transketolase
C4E25_RS10305	COG3959	Transketolase, thiamine diphosphate binding domain
C4E25_RS10310	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4E25_RS10330	COG0516	GMP reductase activity
C4E25_RS10330	COG0517	IMP dehydrogenase activity
C4E25_RS10335	COG0736	holo-[acyl-carrier-protein] synthase activity
C4E25_RS10340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4E25_RS10345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4E25_RS10350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4E25_RS10355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4E25_RS10360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4E25_RS10365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4E25_RS10370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4E25_RS10400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4E25_RS10400	COG3608	succinylglutamate desuccinylase aspartoacylase
C4E25_RS10405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4E25_RS10410	COG0698	ribose 5-phosphate isomerase
C4E25_RS10415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4E25_RS10420	COG0009	L-threonylcarbamoyladenylate synthase
C4E25_RS10430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4E25_RS10435	COG2890	protein-(glutamine-N5) methyltransferase activity
C4E25_RS10440	COG3872	metal-dependent enzyme
C4E25_RS10445	COG0254	rRNA binding
C4E25_RS10450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4E25_RS10455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4E25_RS10465	COG2208	phosphoserine phosphatase activity
C4E25_RS10470	COG0248	Ppx GppA phosphatase
C4E25_RS10490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4E25_RS10500	COG3956	TIGRFAM MazG family protein
C4E25_RS10505	COG2244	polysaccharide biosynthetic process
C4E25_RS10510	COG2002	toxin-antitoxin pair type II binding
C4E25_RS10515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E25_RS10520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4E25_RS10525	COG0193	aminoacyl-tRNA hydrolase activity
C4E25_RS10575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4E25_RS10590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4E25_RS10595	COG2088	sporulation resulting in formation of a cellular spore
C4E25_RS10600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4E25_RS10605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4E25_RS10615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4E25_RS10620	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E25_RS10630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4E25_RS10635	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C4E25_RS10650	COG3842	ATPase activity
C4E25_RS10655	COG0613	PHP domain protein
C4E25_RS10665	COG0084	hydrolase, TatD family'
C4E25_RS10670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E25_RS10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E25_RS10675	COG0700	Nucleoside recognition
C4E25_RS10685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4E25_RS10690	COG1522	sequence-specific DNA binding
C4E25_RS10695	COG0617	tRNA 3'-terminal CCA addition
C4E25_RS10700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4E25_RS10705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4E25_RS10710	COG1774	PSP1 C-terminal conserved region
C4E25_RS10715	COG0470	DNA polymerase III
C4E25_RS10725	COG1982	Orn Lys Arg decarboxylase major
C4E25_RS10730	COG2155	Conserved Protein
C4E25_RS10755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4E25_RS10760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4E25_RS10770	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4E25_RS10780	COG3191	aminopeptidase activity
C4E25_RS10790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E25_RS10795	COG0037	tRNA processing
C4E25_RS10805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4E25_RS10820	COG1802	Transcriptional regulator
C4E25_RS10825	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4E25_RS10855	COG0653	protein targeting
C4E25_RS10880	COG2223	nitrite transmembrane transporter activity
C4E25_RS10885	COG0626	cystathionine gamma-synthase activity
C4E25_RS10915	COG4978	Transcriptional regulator
C4E25_RS10915	COG0789	Transcriptional regulator
C4E25_RS10925	COG0577	efflux transmembrane transporter activity
C4E25_RS10925	COG1136	(ABC) transporter
C4E25_RS10930	COG2205	protein histidine kinase activity
C4E25_RS10940	COG1695	Transcriptional regulator
C4E25_RS10955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4E25_RS10965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4E25_RS10975	COG0284	orotidine-5'-phosphate decarboxylase activity
C4E25_RS10995	COG1410	methionine synthase
C4E25_RS10995	COG0646	methionine synthase
C4E25_RS11005	COG1854	S-ribosylhomocysteine lyase activity
C4E25_RS11020	COG1876	peptidase activity
C4E25_RS11025	COG0037	tRNA processing
C4E25_RS11030	COG1408	metallophosphoesterase
C4E25_RS11045	COG1141	Ferredoxin
C4E25_RS11050	COG3964	amidohydrolase
C4E25_RS11060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4E25_RS11070	COG0346	lactoylglutathione lyase activity
C4E25_RS11075	COG0534	Mate efflux family protein
C4E25_RS11090	COG4978	Transcriptional regulator
C4E25_RS11090	COG0789	Transcriptional regulator
C4E25_RS11095	COG3263	regulation of cellular component size
C4E25_RS11100	COG5504	Zn-dependent protease
C4E25_RS11110	COG0519	Catalyzes the synthesis of GMP from XMP
C4E25_RS11120	COG1357	PFAM Pentapeptide repeats (8 copies)
C4E25_RS11125	COG2824	Alkylphosphonate utilization operon protein PhnA
C4E25_RS11130	COG0577	efflux transmembrane transporter activity
C4E25_RS11130	COG1136	(ABC) transporter
C4E25_RS11140	COG5002	protein histidine kinase activity
C4E25_RS11140	COG5001	Diguanylate cyclase
C4E25_RS11140	COG3447	MASE1 domain protein
C4E25_RS11150	COG1473	amidohydrolase
C4E25_RS11165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E25_RS11170	COG0517	IMP dehydrogenase activity
C4E25_RS11170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4E25_RS11190	COG1335	isochorismatase
C4E25_RS11220	COG0583	DNA-binding transcription factor activity
C4E25_RS11225	COG1522	sequence-specific DNA binding
C4E25_RS11225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E25_RS11240	COG3964	amidohydrolase
C4E25_RS11250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS11255	COG2188	Transcriptional regulator
C4E25_RS11260	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E25_RS11265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS11270	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4E25_RS11275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS11280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4E25_RS11295	COG1484	DNA-dependent DNA replication
C4E25_RS11320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4E25_RS11330	COG0305	Participates in initiation and elongation during chromosome replication
C4E25_RS11335	COG0359	binds to the 23S rRNA
C4E25_RS11340	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C4E25_RS11355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4E25_RS11360	COG0629	single-stranded DNA binding
C4E25_RS11365	COG0360	Binds together with S18 to 16S ribosomal RNA
C4E25_RS11370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS11385	COG0425	Belongs to the sulfur carrier protein TusA family
C4E25_RS11400	COG1104	cysteine desulfurase activity
C4E25_RS11405	COG1475	DNA binding
C4E25_RS11410	COG1192	Involved in chromosome partitioning
C4E25_RS11420	COG0357	Ribosomal RNA small subunit methyltransferase G
C4E25_RS11425	COG0445	tRNA wobble uridine modification
C4E25_RS11430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4E25_RS11435	COG1847	R3H domain protein
C4E25_RS11440	COG0706	membrane insertase activity
C4E25_RS11445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4E25_RS11450	COG0594	ribonuclease P activity
C4E25_RS11455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4E25_RS11460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4E25_RS11465	COG0592	DNA-directed DNA polymerase activity
C4E25_RS11475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4E25_RS11480	COG0187	DNA topoisomerase II activity
C4E25_RS11485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4E25_RS11500	COG1366	Belongs to the anti-sigma-factor antagonist family
C4E25_RS11510	COG1191	sigma factor activity
C4E25_RS11560	COG1827	regulation of RNA biosynthetic process
C4E25_RS11565	COG0668	transmembrane transport
C4E25_RS11570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4E25_RS11575	COG0590	tRNA wobble adenosine to inosine editing
C4E25_RS11590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4E25_RS11595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4E25_RS11600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4E25_RS11610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E25_RS11850	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C4E25_RS11855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4E25_RS11860	COG4463	regulation of RNA biosynthetic process
C4E25_RS11865	COG3880	PFAM UvrB UvrC protein
C4E25_RS11870	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C4E25_RS11875	COG0542	response to heat
C4E25_RS11880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4E25_RS11885	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C4E25_RS11890	COG4956	integral membrane protein (PIN domain superfamily)
C4E25_RS11910	COG3507	Belongs to the glycosyl hydrolase 43 family
C4E25_RS11920	COG2205	protein histidine kinase activity
C4E25_RS11935	COG2390	Transcriptional regulator
C4E25_RS11940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4E25_RS11945	COG0022	dehydrogenase e1 component
C4E25_RS11950	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4E25_RS11955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E25_RS11960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E25_RS11960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E25_RS11970	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E25_RS11975	COG3775	system Galactitol-specific IIC component
C4E25_RS11990	COG0095	Lipoate-protein ligase
C4E25_RS11995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4E25_RS12000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4E25_RS12005	COG0442	prolyl-tRNA aminoacylation
C4E25_RS12010	COG0442	prolyl-tRNA aminoacylation
C4E25_RS12015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4E25_RS12025	COG0215	cysteine-tRNA ligase activity
C4E25_RS12040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4E25_RS12045	COG3688	RNA-binding protein containing a PIN domain
C4E25_RS12055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4E25_RS12060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4E25_RS12070	COG0250	Participates in transcription elongation, termination and antitermination
C4E25_RS12075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4E25_RS12080	COG0081	regulation of translation
C4E25_RS12085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4E25_RS12090	COG0222	ribosome binding
C4E25_RS12100	COG0085	RNA polymerase activity
C4E25_RS12105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4E25_RS12110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4E25_RS12115	COG0049	tRNA binding
C4E25_RS12120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4E25_RS12125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4E25_RS12130	COG0051	transcription antitermination factor activity, RNA binding
C4E25_RS12135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4E25_RS12140	COG0088	Forms part of the polypeptide exit tunnel
C4E25_RS12145	COG0089	rRNA binding
C4E25_RS12150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4E25_RS12155	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4E25_RS12160	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4E25_RS12165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4E25_RS12170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4E25_RS12175	COG0255	Belongs to the universal ribosomal protein uL29 family
C4E25_RS12180	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4E25_RS12185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4E25_RS12190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4E25_RS12195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4E25_RS12200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4E25_RS12205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4E25_RS12210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4E25_RS12215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4E25_RS12220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4E25_RS12225	COG1841	ribosomal large subunit assembly
C4E25_RS12230	COG0200	Binds to the 23S rRNA
C4E25_RS12240	COG0563	adenylate kinase activity
C4E25_RS12245	COG0024	Methionine aminopeptidase
C4E25_RS12255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4E25_RS12260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4E25_RS12265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4E25_RS12270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4E25_RS12275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4E25_RS12280	COG0202	RNA polymerase activity
C4E25_RS12285	COG0203	ribosomal protein L17
C4E25_RS12290	COG1122	ATPase activity
C4E25_RS12295	COG1122	ATPase activity
C4E25_RS12300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4E25_RS12305	COG0101	tRNA pseudouridine synthase activity
C4E25_RS12310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4E25_RS12315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4E25_RS12320	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS12565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C4E25_RS12580	COG0280	phosphate acetyltransferase
C4E25_RS12615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E25_RS12620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4E25_RS12625	COG2897	thiosulfate sulfurtransferase activity
C4E25_RS12635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4E25_RS12640	COG2385	sporulation resulting in formation of a cellular spore
C4E25_RS12650	COG1609	Transcriptional regulator
C4E25_RS12655	COG1077	Cell shape determining protein MreB Mrl
C4E25_RS12660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4E25_RS12670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4E25_RS12675	COG3949	Membrane
C4E25_RS12680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4E25_RS12685	COG1040	competence protein
C4E25_RS12690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E25_RS12690	COG3711	transcriptional antiterminator
C4E25_RS12695	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E25_RS12700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS12705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS12715	COG1446	asparaginase
C4E25_RS12720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E25_RS12730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4E25_RS12735	COG0653	protein targeting
C4E25_RS12740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4E25_RS12745	COG2183	response to ionizing radiation
C4E25_RS12750	COG1228	amidohydrolase
C4E25_RS12765	COG0802	atpase or kinase
C4E25_RS12770	COG1214	PFAM Peptidase M22, glycoprotease
C4E25_RS12775	COG0456	acetyltransferase
C4E25_RS12780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4E25_RS12785	COG1882	Formate acetyltransferase
C4E25_RS12795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E25_RS12830	COG0534	Mate efflux family protein
C4E25_RS12835	COG0488	(ABC) transporter
C4E25_RS12840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C4E25_RS12850	COG2221	Nitrite and sulphite reductase 4Fe-4S
C4E25_RS12860	COG1151	hydroxylamine reductase activity
C4E25_RS12875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4E25_RS12920	COG0540	Belongs to the ATCase OTCase family
C4E25_RS12925	COG0543	2 iron, 2 sulfur cluster binding
C4E25_RS12930	COG0167	dihydroorotate dehydrogenase activity
C4E25_RS12935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4E25_RS12945	COG0583	DNA-binding transcription factor activity
C4E25_RS12960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4E25_RS12965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4E25_RS12970	COG0459	protein refolding
C4E25_RS12975	COG1691	(AIR) carboxylase
C4E25_RS12980	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C4E25_RS12985	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C4E25_RS12990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4E25_RS12990	COG0519	Catalyzes the synthesis of GMP from XMP
C4E25_RS13055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4E25_RS13060	COG2771	luxR family
C4E25_RS13060	COG2200	EAL domain
C4E25_RS13075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS13080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E25_RS13090	COG1011	Hydrolase
C4E25_RS13105	COG0778	Nitroreductase
C4E25_RS13110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4E25_RS13115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4E25_RS13120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4E25_RS13125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4E25_RS13130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4E25_RS13135	COG0138	bifunctional purine biosynthesis protein purh
C4E25_RS13140	COG0151	Belongs to the GarS family
C4E25_RS13145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4E25_RS13155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4E25_RS13165	COG1088	dTDP-glucose 4,6-dehydratase activity
C4E25_RS13170	COG0741	lytic transglycosylase activity
C4E25_RS13205	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C4E25_RS13210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4E25_RS13225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4E25_RS13235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C4E25_RS13245	COG1215	transferase activity, transferring glycosyl groups
C4E25_RS13295	COG1454	alcohol dehydrogenase
C4E25_RS13300	COG1533	DNA photolyase activity
C4E25_RS13315	COG1733	regulation of RNA biosynthetic process
C4E25_RS13330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E25_RS13335	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E25_RS13335	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E25_RS13340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E25_RS13340	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E25_RS13365	COG3716	PTS system mannose fructose sorbose family IID component
C4E25_RS13375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E25_RS13395	COG1131	(ABC) transporter
C4E25_RS13415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4E25_RS13425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E25_RS13430	COG1879	ABC-type sugar transport system periplasmic component
C4E25_RS13435	COG1129	ABC transporter
C4E25_RS13440	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E25_RS13445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E25_RS13455	COG1473	amidohydrolase
C4E25_RS13500	COG2217	Heavy metal translocating P-type atpase
C4E25_RS13520	COG0586	Pfam SNARE associated Golgi protein
C4E25_RS13540	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C4E25_RS13550	COG1122	ATPase activity
C4E25_RS13555	COG0210	DNA helicase
C4E25_RS13560	COG1362	aminopeptidase activity
C4E25_RS13570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4E25_RS13585	COG1012	belongs to the aldehyde dehydrogenase family
C4E25_RS13585	COG1454	alcohol dehydrogenase
C4E25_RS13595	COG1136	(ABC) transporter
C4E25_RS13630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4E25_RS13635	COG2357	RelA SpoT domain protein
C4E25_RS13655	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C4E25_RS13680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS13680	COG1263	PTS System
C4E25_RS13680	COG2190	(PTS) system
C4E25_RS13685	COG2723	6-phospho-beta-galactosidase activity
C4E25_RS13690	COG3711	transcriptional antiterminator
C4E25_RS13695	COG0367	asparagine synthase
C4E25_RS13710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4E25_RS13735	COG1960	acyl-CoA dehydrogenase activity
C4E25_RS13740	COG2086	electron transfer activity
C4E25_RS13745	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E25_RS13750	COG3829	transcription factor binding
C4E25_RS13755	COG0191	fructose-bisphosphate aldolase activity
C4E25_RS13765	COG1187	pseudouridine synthase activity
C4E25_RS13830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E25_RS13835	COG0745	RESPONSE REGULATOR receiver
C4E25_RS13850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E25_RS13870	COG3254	rhamnose metabolic process
C4E25_RS13890	COG0626	cystathionine gamma-synthase activity
C4E25_RS13900	COG3829	transcription factor binding
C4E25_RS13905	COG3804	dihydrodipicolinate reductase
C4E25_RS13915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4E25_RS13925	COG5012	cobalamin binding
C4E25_RS13935	COG3457	Alanine racemase
C4E25_RS13940	COG1757	Na H antiporter
C4E25_RS13955	COG1051	belongs to the nudix hydrolase family
C4E25_RS13970	COG3973	AAA domain
C4E25_RS13980	COG1136	(ABC) transporter
C4E25_RS13990	COG5002	protein histidine kinase activity
C4E25_RS13995	COG0745	RESPONSE REGULATOR receiver
C4E25_RS14015	COG1131	(ABC) transporter
C4E25_RS14095	COG1595	DNA-templated transcription, initiation
C4E25_RS14180	COG0768	penicillin binding
C4E25_RS14205	COG1131	(ABC) transporter
C4E25_RS14220	COG0745	RESPONSE REGULATOR receiver
C4E25_RS14225	COG5002	protein histidine kinase activity
C4E25_RS14230	COG1136	(ABC) transporter
C4E25_RS14230	COG0577	efflux transmembrane transporter activity
C4E25_RS14235	COG1136	(ABC) transporter
C4E25_RS14240	COG5002	protein histidine kinase activity
C4E25_RS14245	COG0745	RESPONSE REGULATOR receiver
C4E25_RS14250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4E25_RS14265	COG1063	alcohol dehydrogenase
C4E25_RS14275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS14285	COG3716	PTS system mannose fructose sorbose family IID component
C4E25_RS14295	COG5002	protein histidine kinase activity
C4E25_RS14305	COG1686	Belongs to the peptidase S11 family
C4E25_RS14310	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E25_RS14310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E25_RS14330	COG2205	protein histidine kinase activity
C4E25_RS14355	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E25_RS14360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4E25_RS14380	COG2378	regulation of single-species biofilm formation
C4E25_RS14390	COG2201	protein-glutamate methylesterase activity
C4E25_RS14395	COG1776	CheC inhibitor of MCP methylation
C4E25_RS14400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4E25_RS14405	COG0835	chemotaxis
C4E25_RS14415	COG0840	transmembrane signaling receptor activity
C4E25_RS14420	COG2198	Histidine kinase
C4E25_RS14420	COG0643	Histidine kinase
C4E25_RS14425	COG0835	chemotaxis
C4E25_RS14435	COG2201	protein-glutamate methylesterase activity
C4E25_RS14485	COG2339	peptidase activity
C4E25_RS14490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4E25_RS14490	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C4E25_RS14495	COG0681	Belongs to the peptidase S26 family
C4E25_RS14510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4E25_RS14515	COG2066	Belongs to the glutaminase family
C4E25_RS14525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C4E25_RS14545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4E25_RS14550	COG1067	ATP-dependent peptidase activity
C4E25_RS14555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4E25_RS14560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4E25_RS14570	COG1744	ABC transporter substrate-binding protein PnrA-like
C4E25_RS14605	COG4399	Belongs to the UPF0754 family
C4E25_RS14605	COG4399	Belongs to the UPF0754 family
C4E25_RS14610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4E25_RS14655	COG1309	transcriptional regulator
C4E25_RS14660	COG3848	Pyruvate phosphate dikinase
C4E25_RS14660	COG0574	Belongs to the PEP-utilizing enzyme family
C4E25_RS14670	COG5001	Diguanylate cyclase
C4E25_RS14670	COG1716	ATPase activity
C4E25_RS14675	COG2199	diguanylate cyclase activity
C4E25_RS14720	COG3969	phosphoadenosine phosphosulfate
C4E25_RS14725	COG1475	DNA binding
C4E25_RS14740	COG3546	catalase activity
C4E25_RS14750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4E25_RS14765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C4E25_RS14765	COG0456	acetyltransferase
C4E25_RS14800	COG0789	Transcriptional regulator
C4E25_RS14800	COG4978	Transcriptional regulator
C4E25_RS14845	COG0305	Participates in initiation and elongation during chromosome replication
C4E25_RS14865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4E25_RS14925	COG1131	(ABC) transporter
C4E25_RS14935	COG1802	Transcriptional regulator
C4E25_RS14940	COG4946	Tricorn protease homolog
C4E25_RS14940	COG1506	peptidase
C4E25_RS14940	COG0823	Involved in the tonB-independent uptake of proteins
C4E25_RS14945	COG4946	Tricorn protease homolog
C4E25_RS14945	COG0823	Involved in the tonB-independent uptake of proteins
C4E25_RS14945	COG1506	peptidase
C4E25_RS14955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS14975	COG0038	chloride channel
C4E25_RS15060	COG0745	RESPONSE REGULATOR receiver
C4E25_RS15065	COG0745	RESPONSE REGULATOR receiver
C4E25_RS15065	COG2205	protein histidine kinase activity
C4E25_RS15065	COG3292	Two component regulator propeller
C4E25_RS15100	COG1595	DNA-templated transcription, initiation
C4E25_RS15110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4E25_RS15115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4E25_RS15120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4E25_RS15170	COG0789	Transcriptional regulator
C4E25_RS15190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4E25_RS15195	COG0569	domain protein
C4E25_RS15200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4E25_RS15205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4E25_RS15210	COG0072	phenylalanine-tRNA ligase activity
C4E25_RS15210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E25_RS15235	COG0826	peptidase U32
C4E25_RS15245	COG1051	belongs to the nudix hydrolase family
C4E25_RS15255	COG3706	GGDEF domain
C4E25_RS15260	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E25_RS15265	COG1193	negative regulation of DNA recombination
C4E25_RS15270	COG1683	Conserved Protein
C4E25_RS15275	COG0018	arginyl-trna synthetase
C4E25_RS15300	COG0583	DNA-binding transcription factor activity
C4E25_RS15305	COG0110	maltose O-acetyltransferase activity
C4E25_RS15310	COG0280	phosphate acetyltransferase
C4E25_RS15315	COG1151	hydroxylamine reductase activity
C4E25_RS15325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C4E25_RS15330	COG3404	Formiminotransferase-cyclodeaminase
C4E25_RS15335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4E25_RS15345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4E25_RS15345	COG0646	methionine synthase
C4E25_RS15350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E25_RS15380	COG0509	glycine decarboxylation via glycine cleavage system
C4E25_RS15400	COG0095	Lipoate-protein ligase
C4E25_RS15420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E25_RS15435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4E25_RS15435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E25_RS15445	COG3192	ethanolamine utilization protein
C4E25_RS15450	COG1349	DNA-binding transcription factor activity
C4E25_RS15460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4E25_RS15465	COG1360	Flagellar Motor Protein
C4E25_RS15485	COG0210	DNA helicase
C4E25_RS15490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E25_RS15495	COG0765	amino acid transport
C4E25_RS15500	COG1126	abc transporter atp-binding protein
C4E25_RS15510	COG0301	tRNA thio-modification
C4E25_RS15520	COG0778	Nitroreductase
C4E25_RS15525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E25_RS15535	COG0530	calcium, potassium:sodium antiporter activity
C4E25_RS15540	COG0513	Belongs to the DEAD box helicase family
C4E25_RS15560	COG3732	PTS system glucitol sorbitol-specific
C4E25_RS15575	COG1028	Short-chain dehydrogenase reductase Sdr
C4E25_RS15580	COG0243	molybdopterin cofactor binding
C4E25_RS15585	COG1366	Belongs to the anti-sigma-factor antagonist family
C4E25_RS15590	COG2172	sigma factor antagonist activity
C4E25_RS15595	COG1191	sigma factor activity
C4E25_RS15605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4E25_RS15630	COG1473	amidohydrolase
C4E25_RS15640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4E25_RS15650	COG0750	zinc metalloprotease
C4E25_RS15655	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS15660	COG0488	(ABC) transporter
C4E25_RS15675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4E25_RS15690	COG1739	Uncharacterized protein family UPF0029
C4E25_RS15700	COG0730	response to heat
C4E25_RS15705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4E25_RS15710	COG0217	transcriptional regulatory protein
C4E25_RS15715	COG1024	Enoyl-CoA hydratase
C4E25_RS15720	COG2610	gluconate transmembrane transporter activity
C4E25_RS15735	COG2086	electron transfer activity
C4E25_RS15740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E25_RS15785	COG2186	Transcriptional regulator
C4E25_RS15790	COG2814	Major facilitator Superfamily
C4E25_RS15795	COG1263	PTS System
C4E25_RS15795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E25_RS15795	COG2190	(PTS) system
C4E25_RS15800	COG2723	6-phospho-beta-galactosidase activity
C4E25_RS15810	COG0745	RESPONSE REGULATOR receiver
C4E25_RS15815	COG5002	protein histidine kinase activity
C4E25_RS15835	COG1592	Rubrerythrin
C4E25_RS15845	COG2033	superoxide reductase activity
C4E25_RS15850	COG0069	glutamate synthase activity
C4E25_RS15895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4E25_RS15905	COG0473	3-isopropylmalate dehydrogenase activity
C4E25_RS15910	COG1846	Transcriptional regulator
C4E25_RS15935	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4E25_RS15940	COG0138	bifunctional purine biosynthesis protein purh
C4E25_RS16015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4E25_RS16030	COG0601	transmembrane transport
C4E25_RS16035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E25_RS16045	COG0444	Belongs to the ABC transporter superfamily
C4E25_RS16050	COG4608	Belongs to the ABC transporter superfamily
C4E25_RS16055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E25_RS16055	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E25_RS16070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E25_RS16080	COG1486	melibiose metabolic process
C4E25_RS16090	COG1073	alpha beta
C4E25_RS16100	COG1910	domain protein
C4E25_RS16105	COG0725	ABC transporter, periplasmic molybdate-binding protein
C4E25_RS16110	COG4149	molybdate abc transporter
C4E25_RS16115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4E25_RS16120	COG0110	maltose O-acetyltransferase activity
C4E25_RS16135	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4E25_RS16140	COG2984	ABC transporter substrate binding protein
C4E25_RS16150	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4E25_RS16155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4E25_RS16155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4E25_RS16170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4E25_RS16175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4E25_RS16180	COG0297	glycogen (starch) synthase activity
C4E25_RS16185	COG0058	SHG alpha-glucan phosphorylase activity
C4E25_RS16195	COG1802	Transcriptional regulator
C4E25_RS16200	COG1982	Orn Lys Arg decarboxylase major
C4E25_RS16205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C4E25_RS16210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4E25_RS16215	COG0010	Belongs to the arginase family
C4E25_RS16250	COG4868	Belongs to the UPF0371 family
C4E25_RS16255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4E25_RS16265	COG1174	glycine betaine transport
C4E25_RS16270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4E25_RS16300	COG0534	Mate efflux family protein
C4E25_RS16305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4E25_RS16305	COG0539	negative regulation of cytoplasmic translation
C4E25_RS16310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E25_RS16320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4E25_RS16325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4E25_RS16330	COG0066	3-isopropylmalate dehydratase activity
C4E25_RS16335	COG0473	3-isopropylmalate dehydrogenase activity
C4E25_RS16350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4E25_RS16365	COG3447	MASE1 domain protein
C4E25_RS16365	COG5001	Diguanylate cyclase
C4E25_RS16365	COG5002	protein histidine kinase activity
C4E25_RS16390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4E25_RS16395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E25_RS16405	COG0281	malic enzyme
C4E25_RS16420	COG0745	RESPONSE REGULATOR receiver
C4E25_RS16425	COG5002	protein histidine kinase activity
C4E25_RS16430	COG0577	efflux transmembrane transporter activity
C4E25_RS16430	COG1136	(ABC) transporter
C4E25_RS16450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4E25_RS16455	COG0363	glucosamine-6-phosphate deaminase activity
C4E25_RS16475	COG5001	Diguanylate cyclase
C4E25_RS16485	COG4978	Transcriptional regulator
C4E25_RS16485	COG0789	Transcriptional regulator
C4E25_RS16495	COG1132	(ABC) transporter
C4E25_RS16515	COG2364	Membrane
C4E25_RS16530	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4E25_RS16535	COG1177	transmembrane transport
C4E25_RS16540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4E25_RS16550	COG5298	Protein conserved in bacteria
C4E25_RS16555	COG1215	transferase activity, transferring glycosyl groups
C4E25_RS16570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4E25_RS16600	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS16605	COG2247	cell wall binding repeat
C4E25_RS16605	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E25_RS16615	COG1074	ATP-dependent DNA helicase activity
C4E25_RS16625	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C4E25_RS16630	COG1074	ATP-dependent DNA helicase activity
C4E25_RS16635	COG0420	3'-5' exonuclease activity
C4E25_RS16645	COG4536	flavin adenine dinucleotide binding
C4E25_RS16655	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E25_RS16665	COG0622	Phosphoesterase
C4E25_RS16670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4E25_RS16675	COG1131	(ABC) transporter
C4E25_RS16695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4E25_RS16700	COG1960	acyl-CoA dehydrogenase activity
C4E25_RS16705	COG2086	electron transfer activity
C4E25_RS16710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E25_RS16725	COG0183	Belongs to the thiolase family
C4E25_RS16730	COG0564	pseudouridine synthase activity
C4E25_RS16740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4E25_RS16795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E25_RS16800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS16805	COG4224	UPF0291 protein
C4E25_RS16810	COG1362	aminopeptidase activity
C4E25_RS16815	COG2188	Transcriptional regulator
C4E25_RS16835	COG3715	PTS system
C4E25_RS16840	COG3716	PTS system mannose fructose sorbose family IID component
C4E25_RS16845	COG0583	DNA-binding transcription factor activity
C4E25_RS16865	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E25_RS16870	COG1132	(ABC) transporter
C4E25_RS16880	COG1473	amidohydrolase
C4E25_RS16895	COG3279	Response regulator of the LytR AlgR family
C4E25_RS16910	COG1882	Formate acetyltransferase
C4E25_RS16915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E25_RS16920	COG1396	sequence-specific DNA binding
C4E25_RS16945	COG2207	Transcriptional regulator
C4E25_RS16945	COG3708	Transcriptional regulator
C4E25_RS16980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4E25_RS16980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4E25_RS16985	COG0237	dephospho-CoA kinase activity
C4E25_RS17010	COG0346	lactoylglutathione lyase activity
C4E25_RS17015	COG0791	NLP P60 protein
C4E25_RS17025	COG4656	Part of a membrane complex involved in electron transport
C4E25_RS17030	COG4658	electron transport chain
C4E25_RS17035	COG4659	FMN binding
C4E25_RS17040	COG4660	Part of a membrane complex involved in electron transport
C4E25_RS17045	COG4657	Part of a membrane complex involved in electron transport
C4E25_RS17050	COG1245	4Fe-4S binding domain
C4E25_RS17050	COG2878	Part of a membrane complex involved in electron transport
C4E25_RS17055	COG0424	maF-like protein
C4E25_RS17060	COG2003	Belongs to the UPF0758 family
C4E25_RS17065	COG1077	Cell shape determining protein MreB Mrl
C4E25_RS17085	COG0850	regulation of cytokinetic process
C4E25_RS17090	COG2894	cell division
C4E25_RS17095	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4E25_RS17100	COG0772	Belongs to the SEDS family
C4E25_RS17105	COG1803	Methylglyoxal synthase
C4E25_RS17110	COG1695	Transcriptional regulator
C4E25_RS17125	COG0426	domain, Protein
C4E25_RS17140	COG1530	ribonuclease E activity
C4E25_RS17145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4E25_RS17155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4E25_RS17160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4E25_RS17170	COG0460	homoserine dehydrogenase
C4E25_RS17180	COG3314	Sporulation integral membrane protein YlbJ
C4E25_RS17185	COG2186	Transcriptional regulator
C4E25_RS17190	COG3875	lactate racemase activity
C4E25_RS17195	COG2086	electron transfer activity
C4E25_RS17200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E25_RS17205	COG0277	FAD linked oxidase domain protein
C4E25_RS17210	COG1323	Belongs to the UPF0348 family
C4E25_RS17215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4E25_RS17225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4E25_RS17235	COG0416	fatty acid biosynthetic process
C4E25_RS17240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4E25_RS17250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4E25_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
C4E25_RS17260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4E25_RS17265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4E25_RS17270	COG3706	GGDEF domain
C4E25_RS17285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4E25_RS17305	COG3854	ATPases associated with a variety of cellular activities
C4E25_RS17345	COG1302	Protein conserved in bacteria
C4E25_RS17350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4E25_RS17355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4E25_RS17360	COG1570	exodeoxyribonuclease VII activity
C4E25_RS17365	COG1722	exodeoxyribonuclease VII activity
C4E25_RS17375	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C4E25_RS17380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4E25_RS17385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4E25_RS17390	COG0497	DNA recombination
C4E25_RS17400	COG0456	acetyltransferase
C4E25_RS17405	COG0456	acetyltransferase
C4E25_RS17410	COG0750	zinc metalloprotease
C4E25_RS17445	COG0494	nUDIX hydrolase
C4E25_RS17455	COG4974	Belongs to the 'phage' integrase family
C4E25_RS17460	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C4E25_RS17475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4E25_RS17480	COG4122	O-methyltransferase activity
C4E25_RS17485	COG0826	peptidase U32
C4E25_RS17490	COG0768	penicillin binding
C4E25_RS17605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4E25_RS17615	COG0571	ribonuclease III activity
C4E25_RS17625	COG1196	nuclear chromosome segregation
C4E25_RS17630	COG0552	protein localization to endoplasmic reticulum
C4E25_RS17640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4E25_RS17645	COG0228	four-way junction DNA binding
C4E25_RS17655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4E25_RS17660	COG0336	Belongs to the RNA methyltransferase TrmD family
C4E25_RS17665	COG0335	large ribosomal subunit rRNA binding
C4E25_RS17675	COG1114	Component of the transport system for branched-chain amino acids
C4E25_RS17690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4E25_RS17720	COG1131	(ABC) transporter
C4E25_RS17725	COG2197	response regulator
C4E25_RS17730	COG4585	Histidine kinase
C4E25_RS17735	COG0792	nuclease activity
C4E25_RS17740	COG0606	chelatase, subunit chli
C4E25_RS17745	COG0758	DNA mediated transformation
C4E25_RS17750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E25_RS17760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4E25_RS17770	COG1959	2 iron, 2 sulfur cluster binding
C4E25_RS17780	COG0822	iron-sulfur transferase activity
C4E25_RS17785	COG0482	sulfurtransferase activity
C4E25_RS17790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4E25_RS17795	COG4472	Bacterial protein of unknown function (DUF965)
C4E25_RS17805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4E25_RS17810	COG3906	Belongs to the UPF0473 family
C4E25_RS17815	COG0735	belongs to the Fur family
C4E25_RS17825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C4E25_RS17835	COG1686	Belongs to the peptidase S11 family
C4E25_RS17845	COG2207	Transcriptional regulator
C4E25_RS17845	COG1917	Cupin 2, conserved barrel domain protein
C4E25_RS17850	COG1994	Peptidase M50
C4E25_RS17860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4E25_RS17915	COG0779	Required for maturation of 30S ribosomal subunits
C4E25_RS17920	COG0195	Participates in both transcription termination and antitermination
C4E25_RS17925	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C4E25_RS17935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4E25_RS17945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4E25_RS17950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4E25_RS17955	COG0196	riboflavin kinase activity
C4E25_RS17965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4E25_RS17970	COG1307	EDD domain protein, DegV family
C4E25_RS17975	COG1185	polyribonucleotide nucleotidyltransferase activity
C4E25_RS17980	COG0726	polysaccharide deacetylase
C4E25_RS17985	COG0612	Peptidase, M16
C4E25_RS17990	COG1873	PFAM PRC-barrel domain
C4E25_RS17995	COG0527	aspartate kinase activity
C4E25_RS18000	COG0740	serine-type endopeptidase activity
C4E25_RS18010	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4E25_RS18015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E25_RS18025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4E25_RS18030	COG1418	mRNA catabolic process
C4E25_RS18070	COG1968	undecaprenyl-diphosphatase activity
C4E25_RS18080	COG0114	fumarate hydratase activity
C4E25_RS18090	COG0436	Aminotransferase
C4E25_RS18100	COG0708	Exodeoxyribonuclease III
C4E25_RS18115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E25_RS18140	COG1131	(ABC) transporter
C4E25_RS18170	COG1278	Cold shock
C4E25_RS18180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E25_RS18260	COG3299	homolog of phage Mu protein gp47
C4E25_RS18265	COG3778	Protein conserved in bacteria
C4E25_RS18295	COG1396	sequence-specific DNA binding
C4E25_RS18310	COG1396	sequence-specific DNA binding
C4E25_RS18315	COG2814	Major facilitator Superfamily
C4E25_RS18325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4E25_RS18330	COG0471	metal ion transport
C4E25_RS18330	COG3273	potassium ion transport
C4E25_RS18335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4E25_RS18340	COG1914	H( )-stimulated, divalent metal cation uptake system
C4E25_RS18345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4E25_RS18350	COG1984	allophanate hydrolase subunit 2
C4E25_RS18355	COG1396	sequence-specific DNA binding
C4E25_RS18360	COG4948	Mandelate Racemase Muconate Lactonizing
C4E25_RS18410	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4E25_RS18425	COG0584	glycerophosphoryl diester phosphodiesterase
C4E25_RS18470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS18480	COG1058	Belongs to the CinA family
C4E25_RS18480	COG1546	Belongs to the CinA family
C4E25_RS18495	COG3829	transcription factor binding
C4E25_RS18505	COG1242	4 iron, 4 sulfur cluster binding
C4E25_RS18530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4E25_RS18540	COG2203	Gaf domain
C4E25_RS18540	COG2199	diguanylate cyclase activity
C4E25_RS18550	COG0789	Transcriptional regulator
C4E25_RS18550	COG4978	Transcriptional regulator
C4E25_RS18560	COG1285	pathogenesis
C4E25_RS18575	COG0726	polysaccharide deacetylase
C4E25_RS18605	COG2720	vancomycin resistance protein
C4E25_RS18610	COG3829	transcription factor binding
C4E25_RS18625	COG1346	cytolysis
C4E25_RS18630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E25_RS18640	COG2340	Cysteine-rich secretory protein family
C4E25_RS18645	COG0726	polysaccharide deacetylase
C4E25_RS18650	COG0512	Glutamine amidotransferase of anthranilate synthase
C4E25_RS18655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4E25_RS18660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4E25_RS18670	COG0302	gtp cyclohydrolase
C4E25_RS18675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4E25_RS18680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4E25_RS18685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4E25_RS18690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4E25_RS18695	COG0358	DNA primase activity
C4E25_RS18700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4E25_RS18705	COG2384	SAM-dependent methyltransferase
C4E25_RS18710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4E25_RS18715	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4E25_RS18735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E25_RS18745	COG0745	RESPONSE REGULATOR receiver
C4E25_RS18750	COG5002	protein histidine kinase activity
C4E25_RS18750	COG3850	Histidine kinase
C4E25_RS18755	COG0577	efflux transmembrane transporter activity
C4E25_RS18755	COG1136	(ABC) transporter
C4E25_RS18785	COG1132	(ABC) transporter
C4E25_RS18790	COG1132	(ABC) transporter
C4E25_RS18795	COG1773	rubredoxin
C4E25_RS18795	COG1592	Rubrerythrin
C4E25_RS18800	COG0412	Dienelactone hydrolase
C4E25_RS18840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E25_RS18875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4E25_RS18880	COG2011	ABC-type metal ion transport system permease component
C4E25_RS18885	COG1464	Belongs to the NlpA lipoprotein family
C4E25_RS18890	COG5002	protein histidine kinase activity
C4E25_RS18895	COG2094	Belongs to the DNA glycosylase MPG family
C4E25_RS18900	COG1396	sequence-specific DNA binding
C4E25_RS18905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4E25_RS18910	COG4086	secreted protein
C4E25_RS18930	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4E25_RS18935	COG1121	(ABC) transporter
C4E25_RS18940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4E25_RS18945	COG0523	cobalamin synthesis protein
C4E25_RS18950	COG0701	Predicted permease
C4E25_RS18965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4E25_RS18975	COG1131	(ABC) transporter
C4E25_RS18985	COG0534	Mate efflux family protein
C4E25_RS19000	COG3901	Regulator of nitric oxide reductase transcription
C4E25_RS19000	COG0348	domain, Protein
C4E25_RS19025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4E25_RS19030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4E25_RS19040	COG5001	Diguanylate cyclase
C4E25_RS19045	COG4978	Transcriptional regulator
C4E25_RS19045	COG0789	Transcriptional regulator
C4E25_RS19050	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C4E25_RS19070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4E25_RS19075	COG0726	polysaccharide deacetylase
C4E25_RS19085	COG1592	Rubrerythrin
C4E25_RS19085	COG1773	rubredoxin
C4E25_RS19090	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E25_RS19095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4E25_RS19105	COG1136	(ABC) transporter
C4E25_RS19105	COG0577	efflux transmembrane transporter activity
C4E25_RS19115	COG2205	protein histidine kinase activity
C4E25_RS19120	COG0745	RESPONSE REGULATOR receiver
C4E25_RS19125	COG1136	(ABC) transporter
C4E25_RS19130	COG0577	efflux transmembrane transporter activity
C4E25_RS19150	COG1674	ftsk spoiiie
C4E25_RS19160	COG2946	Replication initiation factor