locus-tag	class	description
C4E26_RS00005	COG0791	NLP P60 protein
C4E26_RS00005	COG0741	lytic transglycosylase activity
C4E26_RS00065	COG0405	Gamma-glutamyltransferase
C4E26_RS00080	COG0493	'glutamate synthase
C4E26_RS00080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E26_RS00090	COG1136	(ABC) transporter
C4E26_RS00095	COG0577	efflux transmembrane transporter activity
C4E26_RS00135	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4E26_RS00140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4E26_RS00145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E26_RS00150	COG0131	Imidazoleglycerol-phosphate dehydratase
C4E26_RS00155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4E26_RS00160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4E26_RS00165	COG0107	imidazoleglycerol-phosphate synthase activity
C4E26_RS00170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4E26_RS00170	COG0140	phosphoribosyl-ATP diphosphatase activity
C4E26_RS00175	COG0531	amino acid
C4E26_RS00190	COG1595	DNA-templated transcription, initiation
C4E26_RS00205	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4E26_RS00220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4E26_RS00225	COG0028	Belongs to the TPP enzyme family
C4E26_RS00230	COG3546	catalase activity
C4E26_RS00235	COG1331	Highly conserved protein containing a thioredoxin domain
C4E26_RS00245	COG2267	carboxylic ester hydrolase activity
C4E26_RS00250	COG1136	(ABC) transporter
C4E26_RS00270	COG1388	LysM domain
C4E26_RS00270	COG3584	3D domain protein
C4E26_RS00280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E26_RS00285	COG1295	ribonuclease BN
C4E26_RS00290	COG5002	protein histidine kinase activity
C4E26_RS00295	COG0460	homoserine dehydrogenase
C4E26_RS00305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4E26_RS00310	COG0596	Alpha beta hydrolase
C4E26_RS00325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E26_RS00335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4E26_RS00340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4E26_RS00345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4E26_RS00350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4E26_RS00355	COG1045	serine acetyltransferase
C4E26_RS00365	COG0024	Methionine aminopeptidase
C4E26_RS00380	COG0351	phosphomethylpyrimidine kinase
C4E26_RS00385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C4E26_RS00390	COG0352	thiamine-phosphate diphosphorylase activity
C4E26_RS00395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS00415	COG1725	Transcriptional regulator
C4E26_RS00420	COG1131	(ABC) transporter
C4E26_RS00445	COG0402	S-adenosylhomocysteine deaminase activity
C4E26_RS00455	COG4555	ABC transporter
C4E26_RS00460	COG1668	transmembrane transport
C4E26_RS00465	COG3300	MHYT domain
C4E26_RS00465	COG5001	Diguanylate cyclase
C4E26_RS00470	COG1725	Transcriptional regulator
C4E26_RS00475	COG1131	(ABC) transporter
C4E26_RS00490	COG0668	transmembrane transport
C4E26_RS00500	COG0426	domain, Protein
C4E26_RS00520	COG0367	asparagine synthase
C4E26_RS00525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4E26_RS00540	COG2310	stress, protein
C4E26_RS00555	COG3853	Toxic anion resistance protein (TelA)
C4E26_RS00585	COG5505	Protein of unknown function (DUF819)
C4E26_RS00595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E26_RS00600	COG4605	iron ion homeostasis
C4E26_RS00605	COG4604	ABC transporter, ATP-binding protein
C4E26_RS00610	COG4607	ABC-type enterochelin transport system periplasmic component
C4E26_RS00615	COG5001	Diguanylate cyclase
C4E26_RS00615	COG4251	negative regulation of phosphorylation
C4E26_RS00615	COG3706	GGDEF domain
C4E26_RS00615	COG2203	Gaf domain
C4E26_RS00630	COG0095	Lipoate-protein ligase
C4E26_RS00635	COG1757	Na H antiporter
C4E26_RS00645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4E26_RS00650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4E26_RS00655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E26_RS00660	COG3123	guanosine phosphorylase activity
C4E26_RS00700	COG1396	sequence-specific DNA binding
C4E26_RS00710	COG0584	glycerophosphoryl diester phosphodiesterase
C4E26_RS00725	COG1131	(ABC) transporter
C4E26_RS00735	COG0745	RESPONSE REGULATOR receiver
C4E26_RS00740	COG2205	protein histidine kinase activity
C4E26_RS00755	COG1733	regulation of RNA biosynthetic process
C4E26_RS00760	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C4E26_RS00785	COG1309	transcriptional regulator
C4E26_RS00820	COG0745	RESPONSE REGULATOR receiver
C4E26_RS00825	COG5002	protein histidine kinase activity
C4E26_RS00830	COG3118	belongs to the thioredoxin family
C4E26_RS00860	COG1115	amino acid carrier protein
C4E26_RS00875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4E26_RS00875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4E26_RS00890	COG0514	ATP-dependent DNA helicase (RecQ)
C4E26_RS00895	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4E26_RS00910	COG2022	thiamine diphosphate biosynthetic process
C4E26_RS00925	COG1288	antiporter activity
C4E26_RS00945	COG0393	Putative heavy-metal-binding
C4E26_RS00950	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4E26_RS00960	COG0315	cyclic pyranopterin monophosphate synthase activity
C4E26_RS01040	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4E26_RS01045	COG2207	Transcriptional regulator
C4E26_RS01050	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C4E26_RS01110	COG5012	cobalamin binding
C4E26_RS01115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4E26_RS01125	COG1011	Hydrolase
C4E26_RS01130	COG1917	Cupin 2, conserved barrel domain protein
C4E26_RS01130	COG1396	sequence-specific DNA binding
C4E26_RS01135	COG2610	gluconate transmembrane transporter activity
C4E26_RS01140	COG5002	protein histidine kinase activity
C4E26_RS01145	COG2204	response regulator
C4E26_RS01180	COG0786	glutamate:sodium symporter activity
C4E26_RS01215	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C4E26_RS01220	COG1924	4 iron, 4 sulfur cluster binding
C4E26_RS01260	COG0242	peptide deformylase activity
C4E26_RS01295	COG3326	Membrane
C4E26_RS01310	COG0494	nUDIX hydrolase
C4E26_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E26_RS01365	COG0765	amino acid transport
C4E26_RS01375	COG1393	Belongs to the ArsC family
C4E26_RS01385	COG1606	tRNA processing
C4E26_RS01390	COG0116	Belongs to the methyltransferase superfamily
C4E26_RS01405	COG5002	protein histidine kinase activity
C4E26_RS01405	COG3850	Histidine kinase
C4E26_RS01415	COG0137	argininosuccinate synthase activity
C4E26_RS01425	COG0789	Transcriptional regulator
C4E26_RS01435	COG2323	membrane
C4E26_RS01450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4E26_RS01475	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4E26_RS01480	COG0583	DNA-binding transcription factor activity
C4E26_RS01495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E26_RS01505	COG1609	Transcriptional regulator
C4E26_RS01515	COG1621	beta-fructofuranosidase activity
C4E26_RS01520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E26_RS01530	COG2814	Major facilitator Superfamily
C4E26_RS01560	COG0406	alpha-ribazole phosphatase activity
C4E26_RS01565	COG2081	HI0933 family
C4E26_RS01570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4E26_RS01575	COG0204	Acyl-transferase
C4E26_RS01580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4E26_RS01595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4E26_RS01600	COG3022	response to hydroperoxide
C4E26_RS01615	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C4E26_RS01620	COG1846	Transcriptional regulator
C4E26_RS01625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E26_RS01630	COG2205	protein histidine kinase activity
C4E26_RS01640	COG0598	Magnesium transport protein CorA
C4E26_RS01650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4E26_RS01655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4E26_RS01660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4E26_RS01665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4E26_RS01670	COG1605	Chorismate mutase
C4E26_RS01670	COG0077	Prephenate dehydratase
C4E26_RS01675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4E26_RS01685	COG0287	Prephenate dehydrogenase
C4E26_RS01695	COG5002	protein histidine kinase activity
C4E26_RS01695	COG5001	Diguanylate cyclase
C4E26_RS01715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4E26_RS01720	COG2226	methyltransferase
C4E26_RS01725	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C4E26_RS01755	COG2131	deaminase
C4E26_RS01810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E26_RS01815	COG0582	viral genome integration into host DNA
C4E26_RS01820	COG1192	Involved in chromosome partitioning
C4E26_RS01825	COG1475	DNA binding
C4E26_RS01860	COG1484	DNA-dependent DNA replication
C4E26_RS01980	COG0358	DNA primase activity
C4E26_RS02025	COG1388	LysM domain
C4E26_RS02025	COG0791	NLP P60 protein
C4E26_RS02065	COG2003	Belongs to the UPF0758 family
C4E26_RS02075	COG0488	(ABC) transporter
C4E26_RS02080	COG4509	Sortase family
C4E26_RS02120	COG0596	Alpha beta hydrolase
C4E26_RS02165	COG0358	DNA primase activity
C4E26_RS02280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E26_RS02280	COG0551	DNA topoisomerase type I activity
C4E26_RS02300	COG3843	relaxase mobilization nuclease domain protein
C4E26_RS02330	COG3843	relaxase mobilization nuclease domain protein
C4E26_RS02340	COG2315	Protein conserved in bacteria
C4E26_RS02355	COG3328	transposase activity
C4E26_RS02370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4E26_RS02375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4E26_RS02450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E26_RS02495	COG4819	ethanolamine utilization protein
C4E26_RS02500	COG4303	Ethanolamine ammonia lyase large subunit
C4E26_RS02505	COG4302	ethanolamine ammonia-lyase activity
C4E26_RS02520	COG1454	alcohol dehydrogenase
C4E26_RS02520	COG1012	belongs to the aldehyde dehydrogenase family
C4E26_RS02535	COG4869	propanediol catabolic process
C4E26_RS02545	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C4E26_RS02555	COG3192	ethanolamine utilization protein
C4E26_RS02560	COG4766	ethanolamine catabolic process
C4E26_RS02580	COG1116	anion transmembrane transporter activity
C4E26_RS02600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4E26_RS02605	COG4974	Belongs to the 'phage' integrase family
C4E26_RS02620	COG2359	stage V sporulation protein S
C4E26_RS02625	COG0825	malonyl-CoA metabolic process
C4E26_RS02630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4E26_RS02635	COG0439	Biotin carboxylase
C4E26_RS02640	COG0511	ligase activity, forming carbon-carbon bonds
C4E26_RS02660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4E26_RS02670	COG1136	(ABC) transporter
C4E26_RS02680	COG2205	protein histidine kinase activity
C4E26_RS02685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E26_RS02690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E26_RS02710	COG1136	(ABC) transporter
C4E26_RS02710	COG0577	efflux transmembrane transporter activity
C4E26_RS02715	COG2205	protein histidine kinase activity
C4E26_RS02720	COG0745	RESPONSE REGULATOR receiver
C4E26_RS02730	COG0745	RESPONSE REGULATOR receiver
C4E26_RS02735	COG5002	protein histidine kinase activity
C4E26_RS02740	COG1136	(ABC) transporter
C4E26_RS02740	COG0577	efflux transmembrane transporter activity
C4E26_RS02750	COG2264	protein methyltransferase activity
C4E26_RS02780	COG1811	Na channel or pump
C4E26_RS02785	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C4E26_RS02800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E26_RS02805	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C4E26_RS02810	COG1923	regulation of RNA biosynthetic process
C4E26_RS02815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4E26_RS02820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4E26_RS02825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4E26_RS02830	COG1116	anion transmembrane transporter activity
C4E26_RS02835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4E26_RS02840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E26_RS02860	COG1733	regulation of RNA biosynthetic process
C4E26_RS02865	COG0384	phenazine biosynthesis protein PhzF
C4E26_RS02870	COG0494	nUDIX hydrolase
C4E26_RS02885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E26_RS02890	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS02890	COG2247	cell wall binding repeat
C4E26_RS03040	COG0730	response to heat
C4E26_RS03045	COG2207	Transcriptional regulator
C4E26_RS03050	COG1321	iron dependent repressor
C4E26_RS03055	COG0789	Transcriptional regulator
C4E26_RS03070	COG1404	Belongs to the peptidase S8 family
C4E26_RS03085	COG0129	dihydroxy-acid dehydratase activity
C4E26_RS03115	COG2207	Transcriptional regulator
C4E26_RS03120	COG2814	Major facilitator Superfamily
C4E26_RS03140	COG1725	Transcriptional regulator
C4E26_RS03165	COG1794	racemase activity, acting on amino acids and derivatives
C4E26_RS03175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4E26_RS03180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4E26_RS03185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4E26_RS03190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4E26_RS03200	COG0456	acetyltransferase
C4E26_RS03210	COG1309	transcriptional regulator
C4E26_RS03230	COG3655	Transcriptional regulator
C4E26_RS03255	COG1737	Transcriptional regulator
C4E26_RS03260	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C4E26_RS03265	COG1187	pseudouridine synthase activity
C4E26_RS03270	COG0628	permease
C4E26_RS03280	COG0019	diaminopimelate decarboxylase activity
C4E26_RS03285	COG0527	aspartate kinase activity
C4E26_RS03315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4E26_RS03320	COG1597	lipid kinase activity
C4E26_RS03350	COG0582	viral genome integration into host DNA
C4E26_RS03360	COG0488	(ABC) transporter
C4E26_RS03375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4E26_RS03385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E26_RS03385	COG2080	2 iron, 2 sulfur cluster binding
C4E26_RS03395	COG2233	PERMEase
C4E26_RS03410	COG0167	dihydroorotate dehydrogenase activity
C4E26_RS03415	COG0402	S-adenosylhomocysteine deaminase activity
C4E26_RS03435	COG0402	S-adenosylhomocysteine deaminase activity
C4E26_RS03460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E26_RS03485	COG3829	transcription factor binding
C4E26_RS03495	COG1401	restriction endodeoxyribonuclease activity
C4E26_RS03510	COG4708	membrane
C4E26_RS03520	COG2080	2 iron, 2 sulfur cluster binding
C4E26_RS03520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E26_RS03555	COG1131	(ABC) transporter
C4E26_RS03565	COG2252	PERMEase
C4E26_RS03570	COG0534	Mate efflux family protein
C4E26_RS03580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E26_RS03585	COG1349	DNA-binding transcription factor activity
C4E26_RS03595	COG5002	protein histidine kinase activity
C4E26_RS03600	COG0745	RESPONSE REGULATOR receiver
C4E26_RS03605	COG2217	Heavy metal translocating P-type atpase
C4E26_RS03620	COG1217	gtp-binding protein TYPA
C4E26_RS03625	COG0492	ferredoxin-NADP+ reductase activity
C4E26_RS03665	COG1247	-acetyltransferase
C4E26_RS03690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4E26_RS03695	COG0750	zinc metalloprotease
C4E26_RS03700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4E26_RS03710	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4E26_RS03715	COG1518	maintenance of DNA repeat elements
C4E26_RS03775	COG4589	Belongs to the CDS family
C4E26_RS03790	COG0233	cytoplasmic translational termination
C4E26_RS03795	COG0528	UMP kinase activity
C4E26_RS03800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4E26_RS03805	COG0052	Belongs to the universal ribosomal protein uS2 family
C4E26_RS03810	COG1686	Belongs to the peptidase S11 family
C4E26_RS03830	COG1193	negative regulation of DNA recombination
C4E26_RS03845	COG2720	vancomycin resistance protein
C4E26_RS03865	COG1363	Peptidase, m42
C4E26_RS03875	COG1160	GTP binding
C4E26_RS03880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4E26_RS03920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4E26_RS03935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4E26_RS03935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4E26_RS03945	COG1151	hydroxylamine reductase activity
C4E26_RS03965	COG1301	dicarboxylic acid transport
C4E26_RS03970	COG1126	abc transporter atp-binding protein
C4E26_RS03995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E26_RS04000	COG0437	4 iron, 4 sulfur cluster binding
C4E26_RS04005	COG0243	molybdopterin cofactor binding
C4E26_RS04010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4E26_RS04015	COG0596	Alpha beta hydrolase
C4E26_RS04040	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4E26_RS04045	COG1554	hydrolase, family 65, central catalytic
C4E26_RS04050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E26_RS04075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E26_RS04095	COG1528	Iron-storage protein
C4E26_RS04115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4E26_RS04115	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4E26_RS04125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E26_RS04140	COG1309	transcriptional regulator
C4E26_RS04145	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4E26_RS04150	COG0628	permease
C4E26_RS04155	COG1012	belongs to the aldehyde dehydrogenase family
C4E26_RS04170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4E26_RS04175	COG1132	(ABC) transporter
C4E26_RS04195	COG0288	reversible hydration of carbon dioxide
C4E26_RS04215	COG0710	3-dehydroquinate dehydratase activity
C4E26_RS04225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E26_RS04285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4E26_RS04290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E26_RS04295	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C4E26_RS04315	COG0017	Asparaginyl-tRNA synthetase
C4E26_RS04330	COG1404	Belongs to the peptidase S8 family
C4E26_RS04340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E26_RS04355	COG1509	lysine 2,3-aminomutase activity
C4E26_RS04385	COG0662	Cupin 2, conserved barrel domain protein
C4E26_RS04390	COG3104	oligopeptide transport
C4E26_RS04395	COG0006	proline dipeptidase activity
C4E26_RS04405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E26_RS04420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4E26_RS04420	COG0723	plastoquinol--plastocyanin reductase activity
C4E26_RS04430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS04430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS04430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS04435	COG1105	Belongs to the carbohydrate kinase PfkB family
C4E26_RS04440	COG3711	transcriptional antiterminator
C4E26_RS04440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS04445	COG2365	Tyrosine phosphatase family
C4E26_RS04465	COG1115	amino acid carrier protein
C4E26_RS04470	COG0235	Class ii aldolase
C4E26_RS04475	COG0235	Class ii aldolase
C4E26_RS04480	COG1063	alcohol dehydrogenase
C4E26_RS04485	COG3775	system Galactitol-specific IIC component
C4E26_RS04490	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E26_RS04495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS04495	COG2213	PTS system mannitol-specific
C4E26_RS04500	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E26_RS04500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E26_RS04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS04525	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4E26_RS04535	COG5002	protein histidine kinase activity
C4E26_RS04595	COG3620	sequence-specific DNA binding
C4E26_RS04645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E26_RS04650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E26_RS04655	COG0698	ribose 5-phosphate isomerase
C4E26_RS04660	COG3958	Transketolase
C4E26_RS04665	COG3959	Transketolase, thiamine diphosphate binding domain
C4E26_RS04675	COG1063	alcohol dehydrogenase
C4E26_RS04680	COG3775	system Galactitol-specific IIC component
C4E26_RS04685	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E26_RS04695	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E26_RS04695	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E26_RS04700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E26_RS04705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4E26_RS04710	COG0246	Mannitol dehydrogenase
C4E26_RS04715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS04720	COG3711	transcriptional antiterminator
C4E26_RS04730	COG0517	IMP dehydrogenase activity
C4E26_RS04730	COG0516	GMP reductase activity
C4E26_RS04735	COG3853	Toxic anion resistance protein (TelA)
C4E26_RS04745	COG1454	alcohol dehydrogenase
C4E26_RS04750	COG0427	acetyl-CoA hydrolase
C4E26_RS04765	COG1012	belongs to the aldehyde dehydrogenase family
C4E26_RS04770	COG0427	acetyl-CoA hydrolase
C4E26_RS04775	COG2985	domain, Protein
C4E26_RS04775	COG0490	domain, Protein
C4E26_RS04775	COG2985	domain, Protein
C4E26_RS04775	COG0490	domain, Protein
C4E26_RS04780	COG0583	DNA-binding transcription factor activity
C4E26_RS04790	COG0006	proline dipeptidase activity
C4E26_RS04820	COG3118	belongs to the thioredoxin family
C4E26_RS04840	COG0561	phosphatase activity
C4E26_RS04855	COG1116	anion transmembrane transporter activity
C4E26_RS04865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E26_RS04905	COG0157	Belongs to the NadC ModD family
C4E26_RS04915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4E26_RS04920	COG1966	Carbon starvation protein
C4E26_RS04935	COG0628	permease
C4E26_RS04945	COG2364	Membrane
C4E26_RS04950	COG3426	butyrate kinase activity
C4E26_RS04975	COG2199	diguanylate cyclase activity
C4E26_RS04980	COG2199	diguanylate cyclase activity
C4E26_RS04980	COG2203	Gaf domain
C4E26_RS05040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E26_RS05040	COG0072	phenylalanine-tRNA ligase activity
C4E26_RS05045	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4E26_RS05050	COG2176	DNA-directed DNA polymerase activity
C4E26_RS05070	COG0037	tRNA processing
C4E26_RS05085	COG3546	catalase activity
C4E26_RS05090	COG1388	LysM domain
C4E26_RS05090	COG3103	Sh3 type 3 domain protein
C4E26_RS05090	COG0791	NLP P60 protein
C4E26_RS05100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E26_RS05100	COG0551	DNA topoisomerase type I activity
C4E26_RS05130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4E26_RS05130	COG0574	Belongs to the PEP-utilizing enzyme family
C4E26_RS05135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4E26_RS05140	COG0517	IMP dehydrogenase activity
C4E26_RS05160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS05160	COG3711	transcriptional antiterminator
C4E26_RS05165	COG3732	PTS system glucitol sorbitol-specific
C4E26_RS05175	COG2207	Transcriptional regulator
C4E26_RS05185	COG1288	antiporter activity
C4E26_RS05195	COG1115	amino acid carrier protein
C4E26_RS05200	COG2223	nitrite transmembrane transporter activity
C4E26_RS05205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS05210	COG0280	phosphate acetyltransferase
C4E26_RS05230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4E26_RS05230	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4E26_RS05240	COG1414	Transcriptional regulator
C4E26_RS05250	COG0751	glycine-tRNA ligase activity
C4E26_RS05255	COG0752	glycyl-tRNA synthetase alpha subunit
C4E26_RS05265	COG1381	Involved in DNA repair and RecF pathway recombination
C4E26_RS05275	COG2239	Acts as a magnesium transporter
C4E26_RS05280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4E26_RS05285	COG0295	cytidine deaminase activity
C4E26_RS05290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4E26_RS05295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4E26_RS05300	COG1702	phosphate starvation-inducible protein PhoH
C4E26_RS05315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4E26_RS05320	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4E26_RS05325	COG1610	YqeY-like protein
C4E26_RS05330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4E26_RS05335	COG0537	adenosine 5'-monophosphoramidase activity
C4E26_RS05340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E26_RS05345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4E26_RS05350	COG2264	protein methyltransferase activity
C4E26_RS05395	COG1674	ftsk spoiiie
C4E26_RS05405	COG2946	Replication initiation factor
C4E26_RS05435	COG0741	lytic transglycosylase activity
C4E26_RS05435	COG0791	NLP P60 protein
C4E26_RS05495	COG3842	ATPase activity
C4E26_RS05500	COG2508	Transcriptional regulator
C4E26_RS05505	COG0477	Major facilitator Superfamily
C4E26_RS05520	COG0484	heat shock protein binding
C4E26_RS05525	COG0443	Heat shock 70 kDa protein
C4E26_RS05530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4E26_RS05535	COG1420	regulation of RNA biosynthetic process
C4E26_RS05540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4E26_RS05545	COG0531	amino acid
C4E26_RS05550	COG0617	tRNA 3'-terminal CCA addition
C4E26_RS05555	COG0481	GTPase activity
C4E26_RS05580	COG0268	Binds directly to 16S ribosomal RNA
C4E26_RS05590	COG0658	competence protein
C4E26_RS05590	COG2333	competence protein COMEC
C4E26_RS05605	COG2333	competence protein COMEC
C4E26_RS05605	COG0658	competence protein
C4E26_RS05610	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4E26_RS05615	COG3584	3D domain protein
C4E26_RS05615	COG1388	LysM domain
C4E26_RS05620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4E26_RS05640	COG1396	sequence-specific DNA binding
C4E26_RS05645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E26_RS05650	COG0006	proline dipeptidase activity
C4E26_RS05655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS05660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS05670	COG3711	transcriptional antiterminator
C4E26_RS05670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS05675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E26_RS05680	COG1482	cell wall glycoprotein biosynthetic process
C4E26_RS05685	COG5002	protein histidine kinase activity
C4E26_RS05710	COG1686	Belongs to the peptidase S11 family
C4E26_RS05720	COG0165	Argininosuccinate lyase
C4E26_RS05725	COG0561	phosphatase activity
C4E26_RS05730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E26_RS05735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E26_RS05740	COG1876	peptidase activity
C4E26_RS05745	COG1309	transcriptional regulator
C4E26_RS05750	COG2814	Major facilitator Superfamily
C4E26_RS05770	COG1263	PTS System
C4E26_RS05770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS05775	COG3711	transcriptional antiterminator
C4E26_RS05780	COG1263	PTS System
C4E26_RS05780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS05780	COG2190	(PTS) system
C4E26_RS05785	COG0251	oxidation-reduction process
C4E26_RS05790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4E26_RS05830	COG0495	leucyl-tRNA aminoacylation
C4E26_RS05835	COG0799	negative regulation of ribosome biogenesis
C4E26_RS05840	COG1713	HD superfamily hydrolase involved in NAD metabolism
C4E26_RS05845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4E26_RS05850	COG2137	regulation of response to DNA damage stimulus
C4E26_RS05855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4E26_RS05860	COG1309	transcriptional regulator
C4E26_RS05910	COG0577	efflux transmembrane transporter activity
C4E26_RS05910	COG1136	(ABC) transporter
C4E26_RS05920	COG0745	RESPONSE REGULATOR receiver
C4E26_RS05925	COG0737	Belongs to the 5'-nucleotidase family
C4E26_RS05935	COG1234	tRNA 3'-trailer cleavage
C4E26_RS05940	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4E26_RS05945	COG1823	symporter activity
C4E26_RS05970	COG4124	Belongs to the glycosyl hydrolase 26 family
C4E26_RS05970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C4E26_RS05990	COG0395	ABC-type sugar transport system, permease component
C4E26_RS06015	COG0742	ribosomal rna small subunit methyltransferase
C4E26_RS06020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4E26_RS06025	COG1461	Dihydroxyacetone kinase
C4E26_RS06030	COG1302	Protein conserved in bacteria
C4E26_RS06035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4E26_RS06050	COG0789	Transcriptional regulator
C4E26_RS06055	COG3711	transcriptional antiterminator
C4E26_RS06055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS06060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS06060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS06060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS06065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS06065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS06065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS06070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS06075	COG0383	alpha-mannosidase activity
C4E26_RS06080	COG5002	protein histidine kinase activity
C4E26_RS06100	COG1564	THIamine pyrophosphokinase
C4E26_RS06105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E26_RS06110	COG1162	GTPase activity
C4E26_RS06115	COG1028	Short-chain dehydrogenase reductase Sdr
C4E26_RS06120	COG2815	serine threonine protein kinase
C4E26_RS06120	COG0515	serine threonine protein kinase
C4E26_RS06130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4E26_RS06135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4E26_RS06135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4E26_RS06140	COG2738	Putative neutral zinc metallopeptidase
C4E26_RS06150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4E26_RS06155	COG0242	peptide deformylase activity
C4E26_RS06160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4E26_RS06165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4E26_RS06170	COG1758	RNA polymerase activity
C4E26_RS06175	COG0194	GDP metabolic process
C4E26_RS06180	COG1561	YicC-like family, N-terminal region
C4E26_RS06185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4E26_RS06195	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C4E26_RS06200	COG0488	(ABC) transporter
C4E26_RS06210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4E26_RS06215	COG0564	pseudouridine synthase activity
C4E26_RS06220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4E26_RS06230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4E26_RS06235	COG1966	Carbon starvation protein
C4E26_RS06240	COG3279	Response regulator of the LytR AlgR family
C4E26_RS06245	COG3275	phosphorelay sensor kinase activity
C4E26_RS06270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4E26_RS06275	COG0531	amino acid
C4E26_RS06280	COG0006	proline dipeptidase activity
C4E26_RS06285	COG1307	EDD domain protein, DegV family
C4E26_RS06300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E26_RS06305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4E26_RS06315	COG2302	S4 RNA-binding domain
C4E26_RS06325	COG1799	cell septum assembly
C4E26_RS06330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4E26_RS06350	COG3830	Belongs to the UPF0237 family
C4E26_RS06360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C4E26_RS06375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4E26_RS06380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4E26_RS06385	COG1160	GTP binding
C4E26_RS06410	COG5002	protein histidine kinase activity
C4E26_RS06415	COG0745	RESPONSE REGULATOR receiver
C4E26_RS06425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4E26_RS06430	COG1873	PFAM PRC-barrel domain
C4E26_RS06435	COG1191	sigma factor activity
C4E26_RS06440	COG1191	sigma factor activity
C4E26_RS06460	COG3856	small basic protein
C4E26_RS06480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E26_RS06485	COG0772	Belongs to the SEDS family
C4E26_RS06490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4E26_RS06495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4E26_RS06500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4E26_RS06505	COG0768	penicillin binding
C4E26_RS06515	COG0275	rRNA processing
C4E26_RS06520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4E26_RS06525	COG0612	Peptidase, M16
C4E26_RS06535	COG0012	GTP binding
C4E26_RS06540	COG5001	Diguanylate cyclase
C4E26_RS06540	COG3300	MHYT domain
C4E26_RS06545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4E26_RS06555	COG2190	(PTS) system
C4E26_RS06555	COG1263	PTS System
C4E26_RS06555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS06560	COG3711	transcriptional antiterminator
C4E26_RS06565	COG0025	NhaP-type Na H and K H
C4E26_RS06570	COG4608	Belongs to the ABC transporter superfamily
C4E26_RS06575	COG0444	Belongs to the ABC transporter superfamily
C4E26_RS06585	COG0601	transmembrane transport
C4E26_RS06590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E26_RS06595	COG0583	DNA-binding transcription factor activity
C4E26_RS06600	COG0183	Belongs to the thiolase family
C4E26_RS06605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4E26_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
C4E26_RS06620	COG2610	gluconate transmembrane transporter activity
C4E26_RS06625	COG2340	Cysteine-rich secretory protein family
C4E26_RS06635	COG4869	propanediol catabolic process
C4E26_RS06670	COG2081	HI0933 family
C4E26_RS06675	COG0671	phosphoesterase, PA-phosphatase related
C4E26_RS06685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E26_RS06720	COG1388	LysM domain
C4E26_RS06720	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS06740	COG2502	aspartate--ammonia ligase
C4E26_RS06745	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E26_RS06785	COG2252	PERMEase
C4E26_RS06790	COG0402	S-adenosylhomocysteine deaminase activity
C4E26_RS06800	COG2271	Major facilitator Superfamily
C4E26_RS06820	COG0583	DNA-binding transcription factor activity
C4E26_RS06830	COG1376	ErfK ybiS ycfS ynhG family protein
C4E26_RS06835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4E26_RS06840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4E26_RS06865	COG4509	Sortase family
C4E26_RS06885	COG0726	polysaccharide deacetylase
C4E26_RS06890	COG3069	C4-dicarboxylate transmembrane transporter activity
C4E26_RS06895	COG0642	Histidine kinase
C4E26_RS06895	COG5002	protein histidine kinase activity
C4E26_RS06900	COG0745	RESPONSE REGULATOR receiver
C4E26_RS06915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E26_RS06920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4E26_RS06940	COG1937	Protein conserved in bacteria
C4E26_RS06975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E26_RS06980	COG1757	Na H antiporter
C4E26_RS06990	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS06990	COG2247	cell wall binding repeat
C4E26_RS06995	COG0583	DNA-binding transcription factor activity
C4E26_RS07000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4E26_RS07010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4E26_RS07015	COG0124	histidyl-tRNA synthetase
C4E26_RS07020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4E26_RS07025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4E26_RS07030	COG1490	D-aminoacyl-tRNA deacylase activity
C4E26_RS07035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4E26_RS07040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4E26_RS07045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4E26_RS07045	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4E26_RS07090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS07115	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS07120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4E26_RS07130	COG0561	phosphatase activity
C4E26_RS07135	COG1316	TRANSCRIPTIONal
C4E26_RS07140	COG1316	TRANSCRIPTIONal
C4E26_RS07145	COG1649	PFAM Uncharacterised BCR, COG1649
C4E26_RS07150	COG0791	NLP P60 protein
C4E26_RS07160	COG0438	transferase activity, transferring glycosyl groups
C4E26_RS07165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C4E26_RS07170	COG1215	transferase activity, transferring glycosyl groups
C4E26_RS07180	COG1215	transferase activity, transferring glycosyl groups
C4E26_RS07185	COG1215	transferase activity, transferring glycosyl groups
C4E26_RS07185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C4E26_RS07190	COG1216	Glycosyl transferase, family 2
C4E26_RS07210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E26_RS07215	COG0728	peptidoglycan biosynthetic process
C4E26_RS07220	COG2247	cell wall binding repeat
C4E26_RS07220	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS07225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4E26_RS07230	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS07245	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS07245	COG2247	cell wall binding repeat
C4E26_RS07255	COG2246	polysaccharide biosynthetic process
C4E26_RS07260	COG2247	cell wall binding repeat
C4E26_RS07260	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS07275	COG0653	protein targeting
C4E26_RS07300	COG2247	cell wall binding repeat
C4E26_RS07300	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS07320	COG0343	queuine tRNA-ribosyltransferase activity
C4E26_RS07330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4E26_RS07335	COG2255	four-way junction helicase activity
C4E26_RS07340	COG0632	four-way junction helicase activity
C4E26_RS07345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4E26_RS07385	COG2610	gluconate transmembrane transporter activity
C4E26_RS07390	COG2084	Dehydrogenase
C4E26_RS07410	COG1132	(ABC) transporter
C4E26_RS07455	COG0436	Aminotransferase
C4E26_RS07460	COG0697	spore germination
C4E26_RS07475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4E26_RS07490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4E26_RS07495	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4E26_RS07500	COG1473	amidohydrolase
C4E26_RS07505	COG3949	Membrane
C4E26_RS07520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4E26_RS07535	COG0604	alcohol dehydrogenase
C4E26_RS07545	COG1592	Rubrerythrin
C4E26_RS07550	COG0789	Transcriptional regulator
C4E26_RS07560	COG1664	Polymer-forming cytoskeletal
C4E26_RS07565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4E26_RS07565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E26_RS07570	COG1349	DNA-binding transcription factor activity
C4E26_RS07575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4E26_RS07580	COG1696	Membrane protein involved in D-alanine export
C4E26_RS07585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4E26_RS07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E26_RS07610	COG1253	flavin adenine dinucleotide binding
C4E26_RS07615	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4E26_RS07635	COG3829	transcription factor binding
C4E26_RS07635	COG3290	protein histidine kinase activity
C4E26_RS07640	COG2267	carboxylic ester hydrolase activity
C4E26_RS07650	COG0312	modulator of DNA gyrase
C4E26_RS07655	COG0312	modulator of DNA gyrase
C4E26_RS07695	COG1120	ATPase activity
C4E26_RS07700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E26_RS07705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E26_RS07720	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E26_RS07725	COG3394	polysaccharide catabolic process
C4E26_RS07730	COG1486	melibiose metabolic process
C4E26_RS07735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS07745	COG2188	Transcriptional regulator
C4E26_RS07750	COG0366	Alpha amylase catalytic
C4E26_RS07755	COG1263	PTS System
C4E26_RS07755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS07765	COG2188	Transcriptional regulator
C4E26_RS07770	COG1178	ABC-type Fe3 transport system permease component
C4E26_RS07775	COG3842	ATPase activity
C4E26_RS07780	COG1840	ABC-type Fe3 transport system, periplasmic component
C4E26_RS07785	COG1394	ATPase activity, coupled to movement of substances
C4E26_RS07790	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C4E26_RS07795	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C4E26_RS07810	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C4E26_RS07815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4E26_RS07820	COG1269	ATP hydrolysis coupled proton transport
C4E26_RS07845	COG5001	Diguanylate cyclase
C4E26_RS07845	COG3300	MHYT domain
C4E26_RS07850	COG1012	belongs to the aldehyde dehydrogenase family
C4E26_RS07850	COG1454	alcohol dehydrogenase
C4E26_RS07860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4E26_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
C4E26_RS07880	COG1268	BioY protein
C4E26_RS07895	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4E26_RS07910	COG1203	CRISPR-associated helicase, Cas3
C4E26_RS07940	COG0577	efflux transmembrane transporter activity
C4E26_RS07945	COG1136	(ABC) transporter
C4E26_RS07950	COG1968	undecaprenyl-diphosphatase activity
C4E26_RS07955	COG2205	protein histidine kinase activity
C4E26_RS07960	COG0745	RESPONSE REGULATOR receiver
C4E26_RS07975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E26_RS08000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E26_RS08005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E26_RS08015	COG1120	ATPase activity
C4E26_RS08020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E26_RS08030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E26_RS08035	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4E26_RS08060	COG1454	alcohol dehydrogenase
C4E26_RS08065	COG1376	ErfK ybiS ycfS ynhG family protein
C4E26_RS08075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E26_RS08080	COG0785	Cytochrome C biogenesis protein
C4E26_RS08085	COG1733	regulation of RNA biosynthetic process
C4E26_RS08090	COG0383	alpha-mannosidase activity
C4E26_RS08095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS08105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08110	COG3711	transcriptional antiterminator
C4E26_RS08110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS08115	COG4975	Glucose uptake
C4E26_RS08135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4E26_RS08160	COG5002	protein histidine kinase activity
C4E26_RS08170	COG0492	ferredoxin-NADP+ reductase activity
C4E26_RS08175	COG3118	belongs to the thioredoxin family
C4E26_RS08185	COG0384	phenazine biosynthesis protein PhzF
C4E26_RS08205	COG0542	response to heat
C4E26_RS08225	COG2267	carboxylic ester hydrolase activity
C4E26_RS08240	COG1737	Transcriptional regulator
C4E26_RS08260	COG2971	BadF BadG BcrA BcrD
C4E26_RS08265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4E26_RS08275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS08290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4E26_RS08300	COG0642	Histidine kinase
C4E26_RS08315	COG1136	(ABC) transporter
C4E26_RS08325	COG2190	(PTS) system
C4E26_RS08340	COG1263	PTS System
C4E26_RS08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08360	COG1070	Carbohydrate kinase
C4E26_RS08365	COG1940	carbohydrate kinase activity
C4E26_RS08375	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS08375	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08380	COG3716	PTS system mannose fructose sorbose family IID component
C4E26_RS08405	COG0366	Alpha amylase catalytic
C4E26_RS08410	COG0191	fructose-bisphosphate aldolase activity
C4E26_RS08415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS08415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08440	COG3394	polysaccharide catabolic process
C4E26_RS08445	COG2190	(PTS) system
C4E26_RS08445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08445	COG1263	PTS System
C4E26_RS08450	COG2188	Transcriptional regulator
C4E26_RS08455	COG0366	Alpha amylase catalytic
C4E26_RS08465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4E26_RS08475	COG2723	6-phospho-beta-galactosidase activity
C4E26_RS08480	COG2723	6-phospho-beta-galactosidase activity
C4E26_RS08485	COG2190	(PTS) system
C4E26_RS08485	COG1263	PTS System
C4E26_RS08485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08490	COG3711	transcriptional antiterminator
C4E26_RS08500	COG1288	antiporter activity
C4E26_RS08505	COG2190	(PTS) system
C4E26_RS08505	COG1263	PTS System
C4E26_RS08505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E26_RS08520	COG1132	(ABC) transporter
C4E26_RS08525	COG1136	(ABC) transporter
C4E26_RS08540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4E26_RS08550	COG0745	RESPONSE REGULATOR receiver
C4E26_RS08555	COG2190	(PTS) system
C4E26_RS08560	COG0561	phosphatase activity
C4E26_RS08565	COG1454	alcohol dehydrogenase
C4E26_RS08570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E26_RS08575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS08575	COG3711	transcriptional antiterminator
C4E26_RS08580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E26_RS08585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E26_RS08590	COG0205	6-phosphofructokinase activity
C4E26_RS08615	COG1959	2 iron, 2 sulfur cluster binding
C4E26_RS08620	COG0778	Nitroreductase
C4E26_RS08625	COG2723	6-phospho-beta-galactosidase activity
C4E26_RS08630	COG2190	(PTS) system
C4E26_RS08630	COG1263	PTS System
C4E26_RS08630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08640	COG1136	(ABC) transporter
C4E26_RS08665	COG1819	glycosyl
C4E26_RS08670	COG3620	sequence-specific DNA binding
C4E26_RS08680	COG2223	nitrite transmembrane transporter activity
C4E26_RS08685	COG1695	Transcriptional regulator
C4E26_RS08695	COG0640	Transcriptional regulator
C4E26_RS08705	COG2723	6-phospho-beta-galactosidase activity
C4E26_RS08710	COG1263	PTS System
C4E26_RS08710	COG2190	(PTS) system
C4E26_RS08710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08715	COG3711	transcriptional antiterminator
C4E26_RS08725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS08725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08730	COG3711	transcriptional antiterminator
C4E26_RS08735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS08735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS08740	COG0191	fructose-bisphosphate aldolase activity
C4E26_RS08745	COG1178	ABC-type Fe3 transport system permease component
C4E26_RS08750	COG3842	ATPase activity
C4E26_RS08760	COG1840	ABC-type Fe3 transport system, periplasmic component
C4E26_RS08765	COG2723	6-phospho-beta-galactosidase activity
C4E26_RS08770	COG1263	PTS System
C4E26_RS08770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS08770	COG2190	(PTS) system
C4E26_RS08775	COG3711	transcriptional antiterminator
C4E26_RS08800	COG0693	protein deglycase activity
C4E26_RS08855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4E26_RS08885	COG0557	exoribonuclease II activity
C4E26_RS08900	COG1881	PFAM PEBP family protein
C4E26_RS08930	COG0148	phosphopyruvate hydratase activity
C4E26_RS08935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4E26_RS08940	COG0149	triose-phosphate isomerase activity
C4E26_RS08945	COG0126	phosphoglycerate kinase activity
C4E26_RS08955	COG2390	Transcriptional regulator
C4E26_RS08960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4E26_RS08965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E26_RS08975	COG0167	dihydroorotate dehydrogenase activity
C4E26_RS08985	COG0402	S-adenosylhomocysteine deaminase activity
C4E26_RS08990	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4E26_RS09005	COG3829	transcription factor binding
C4E26_RS09010	COG0251	oxidation-reduction process
C4E26_RS09025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4E26_RS09030	COG0789	Transcriptional regulator
C4E26_RS09055	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS09055	COG2247	cell wall binding repeat
C4E26_RS09060	COG1136	(ABC) transporter
C4E26_RS09065	COG0577	efflux transmembrane transporter activity
C4E26_RS09090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4E26_RS09100	COG0789	Transcriptional regulator
C4E26_RS09125	COG2205	protein histidine kinase activity
C4E26_RS09125	COG2770	Histidine kinase
C4E26_RS09130	COG0745	RESPONSE REGULATOR receiver
C4E26_RS09135	COG0706	membrane insertase activity
C4E26_RS09145	COG0778	Nitroreductase
C4E26_RS09155	COG0534	Mate efflux family protein
C4E26_RS09190	COG1732	Glycine betaine
C4E26_RS09195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4E26_RS09205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4E26_RS09210	COG2226	methyltransferase
C4E26_RS09220	COG1473	amidohydrolase
C4E26_RS09225	COG1760	l-serine dehydratase
C4E26_RS09230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E26_RS09235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4E26_RS09240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E26_RS09245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4E26_RS09250	COG2171	N-acyltransferase activity
C4E26_RS09260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4E26_RS09270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4E26_RS09275	COG3681	Belongs to the UPF0597 family
C4E26_RS09285	COG3829	transcription factor binding
C4E26_RS09290	COG2226	methyltransferase
C4E26_RS09315	COG0252	asparaginase activity
C4E26_RS09315	COG5275	peptidyl-tyrosine sulfation
C4E26_RS09320	COG5275	peptidyl-tyrosine sulfation
C4E26_RS09320	COG0252	asparaginase activity
C4E26_RS09335	COG0252	asparaginase activity
C4E26_RS09335	COG5275	peptidyl-tyrosine sulfation
C4E26_RS09355	COG4656	Part of a membrane complex involved in electron transport
C4E26_RS09365	COG0726	polysaccharide deacetylase
C4E26_RS09390	COG0285	dihydrofolate synthase activity
C4E26_RS09400	COG3279	Response regulator of the LytR AlgR family
C4E26_RS09405	COG0525	valine-tRNA ligase activity
C4E26_RS09415	COG0726	polysaccharide deacetylase
C4E26_RS09430	COG0704	Plays a role in the regulation of phosphate uptake
C4E26_RS09435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4E26_RS09440	COG0581	inorganic phosphate transmembrane transporter activity
C4E26_RS09445	COG0573	inorganic phosphate transmembrane transporter activity
C4E26_RS09465	COG0745	RESPONSE REGULATOR receiver
C4E26_RS09470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4E26_RS09475	COG1164	Oligoendopeptidase f
C4E26_RS09480	COG1285	pathogenesis
C4E26_RS09505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4E26_RS09510	COG3716	PTS system mannose fructose sorbose family IID component
C4E26_RS09515	COG3715	PTS system
C4E26_RS09520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS09520	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS09525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS09525	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS09535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4E26_RS09550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4E26_RS09555	COG0166	Belongs to the GPI family
C4E26_RS09565	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4E26_RS09580	COG3012	SEC-C Motif Domain Protein
C4E26_RS09580	COG1405	negative regulation of cell septum assembly
C4E26_RS09605	COG1459	type II secretion system
C4E26_RS09610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4E26_RS09625	COG2814	Major facilitator Superfamily
C4E26_RS09630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4E26_RS09635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4E26_RS09645	COG2059	Chromate
C4E26_RS09650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4E26_RS09655	COG0740	serine-type endopeptidase activity
C4E26_RS09660	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4E26_RS09675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4E26_RS09730	COG2946	Replication initiation factor
C4E26_RS09750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E26_RS09750	COG0493	'glutamate synthase
C4E26_RS09760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E26_RS09770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4E26_RS09830	COG0463	Glycosyl transferase, family 2
C4E26_RS09830	COG0457	Tetratricopeptide repeat
C4E26_RS09845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS09855	COG0778	Nitroreductase
C4E26_RS09860	COG1733	regulation of RNA biosynthetic process
C4E26_RS09875	COG0488	(ABC) transporter
C4E26_RS09880	COG0745	RESPONSE REGULATOR receiver
C4E26_RS09900	COG4555	ABC transporter
C4E26_RS09905	COG2199	diguanylate cyclase activity
C4E26_RS09950	COG0205	6-phosphofructokinase activity
C4E26_RS09960	COG1481	regulation of sporulation
C4E26_RS09975	COG1660	Displays ATPase and GTPase activities
C4E26_RS09985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4E26_RS09990	COG2116	formate transmembrane transporter activity
C4E26_RS09995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4E26_RS10025	COG0322	excinuclease ABC activity
C4E26_RS10035	COG0556	nucleotide-excision repair
C4E26_RS10045	COG1653	transport
C4E26_RS10055	COG1175	transmembrane transport
C4E26_RS10060	COG3842	ATPase activity
C4E26_RS10080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4E26_RS10080	COG1648	precorrin-2 dehydrogenase activity
C4E26_RS10085	COG0113	porphobilinogen synthase activity
C4E26_RS10095	COG0181	hydroxymethylbilane synthase activity
C4E26_RS10135	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4E26_RS10150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4E26_RS10160	COG1797	cobyrinic acid a,c-diamide synthase activity
C4E26_RS10165	COG1492	cobalamin metabolic process
C4E26_RS10175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4E26_RS10185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4E26_RS10205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E26_RS10220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS10225	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E26_RS10230	COG1363	Peptidase, m42
C4E26_RS10235	COG3711	transcriptional antiterminator
C4E26_RS10240	COG0191	fructose-bisphosphate aldolase activity
C4E26_RS10245	COG2222	sugar isomerase
C4E26_RS10250	COG0673	inositol 2-dehydrogenase activity
C4E26_RS10260	COG2188	Transcriptional regulator
C4E26_RS10270	COG0793	Belongs to the peptidase S41A family
C4E26_RS10270	COG3409	Peptidoglycan-binding domain 1 protein
C4E26_RS10275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4E26_RS10285	COG3949	Membrane
C4E26_RS10290	COG3958	Transketolase
C4E26_RS10295	COG3959	Transketolase, thiamine diphosphate binding domain
C4E26_RS10300	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4E26_RS10320	COG0516	GMP reductase activity
C4E26_RS10320	COG0517	IMP dehydrogenase activity
C4E26_RS10325	COG0736	holo-[acyl-carrier-protein] synthase activity
C4E26_RS10330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4E26_RS10335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4E26_RS10340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4E26_RS10345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4E26_RS10350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4E26_RS10355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4E26_RS10360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4E26_RS10390	COG3608	succinylglutamate desuccinylase aspartoacylase
C4E26_RS10390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4E26_RS10395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4E26_RS10400	COG0698	ribose 5-phosphate isomerase
C4E26_RS10405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4E26_RS10410	COG0009	L-threonylcarbamoyladenylate synthase
C4E26_RS10420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4E26_RS10425	COG2890	protein-(glutamine-N5) methyltransferase activity
C4E26_RS10430	COG3872	metal-dependent enzyme
C4E26_RS10435	COG0254	rRNA binding
C4E26_RS10440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4E26_RS10445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4E26_RS10455	COG2208	phosphoserine phosphatase activity
C4E26_RS10460	COG0248	Ppx GppA phosphatase
C4E26_RS10480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4E26_RS10490	COG3956	TIGRFAM MazG family protein
C4E26_RS10495	COG2244	polysaccharide biosynthetic process
C4E26_RS10500	COG2002	toxin-antitoxin pair type II binding
C4E26_RS10505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E26_RS10510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4E26_RS10515	COG0193	aminoacyl-tRNA hydrolase activity
C4E26_RS10565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4E26_RS10580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4E26_RS10585	COG2088	sporulation resulting in formation of a cellular spore
C4E26_RS10590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4E26_RS10595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4E26_RS10605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4E26_RS10610	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E26_RS10620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4E26_RS10625	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C4E26_RS10640	COG3842	ATPase activity
C4E26_RS10645	COG0613	PHP domain protein
C4E26_RS10655	COG0084	hydrolase, TatD family'
C4E26_RS10660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E26_RS10660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E26_RS10665	COG0700	Nucleoside recognition
C4E26_RS10675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4E26_RS10680	COG1522	sequence-specific DNA binding
C4E26_RS10685	COG0617	tRNA 3'-terminal CCA addition
C4E26_RS10690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4E26_RS10695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4E26_RS10700	COG1774	PSP1 C-terminal conserved region
C4E26_RS10705	COG0470	DNA polymerase III
C4E26_RS10715	COG1982	Orn Lys Arg decarboxylase major
C4E26_RS10720	COG2155	Conserved Protein
C4E26_RS10745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4E26_RS10750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4E26_RS10760	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4E26_RS10770	COG3191	aminopeptidase activity
C4E26_RS10780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E26_RS10785	COG0037	tRNA processing
C4E26_RS10795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4E26_RS10810	COG1802	Transcriptional regulator
C4E26_RS10815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4E26_RS10845	COG0653	protein targeting
C4E26_RS10870	COG2223	nitrite transmembrane transporter activity
C4E26_RS10875	COG0626	cystathionine gamma-synthase activity
C4E26_RS10900	COG0564	pseudouridine synthase activity
C4E26_RS10905	COG0789	Transcriptional regulator
C4E26_RS10905	COG4978	Transcriptional regulator
C4E26_RS10915	COG0577	efflux transmembrane transporter activity
C4E26_RS10915	COG1136	(ABC) transporter
C4E26_RS10920	COG2205	protein histidine kinase activity
C4E26_RS10930	COG1695	Transcriptional regulator
C4E26_RS10945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4E26_RS10955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4E26_RS10965	COG0284	orotidine-5'-phosphate decarboxylase activity
C4E26_RS10985	COG0646	methionine synthase
C4E26_RS10985	COG1410	methionine synthase
C4E26_RS10995	COG1854	S-ribosylhomocysteine lyase activity
C4E26_RS11010	COG1876	peptidase activity
C4E26_RS11015	COG0037	tRNA processing
C4E26_RS11020	COG1408	metallophosphoesterase
C4E26_RS11035	COG1141	Ferredoxin
C4E26_RS11040	COG3964	amidohydrolase
C4E26_RS11050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4E26_RS11060	COG0346	lactoylglutathione lyase activity
C4E26_RS11065	COG0534	Mate efflux family protein
C4E26_RS11080	COG4978	Transcriptional regulator
C4E26_RS11080	COG0789	Transcriptional regulator
C4E26_RS11085	COG3263	regulation of cellular component size
C4E26_RS11090	COG5504	Zn-dependent protease
C4E26_RS11100	COG0519	Catalyzes the synthesis of GMP from XMP
C4E26_RS11110	COG1357	PFAM Pentapeptide repeats (8 copies)
C4E26_RS11115	COG2824	Alkylphosphonate utilization operon protein PhnA
C4E26_RS11120	COG1136	(ABC) transporter
C4E26_RS11120	COG0577	efflux transmembrane transporter activity
C4E26_RS11130	COG5001	Diguanylate cyclase
C4E26_RS11130	COG5002	protein histidine kinase activity
C4E26_RS11130	COG3447	MASE1 domain protein
C4E26_RS11140	COG1473	amidohydrolase
C4E26_RS11155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E26_RS11160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4E26_RS11160	COG0517	IMP dehydrogenase activity
C4E26_RS11180	COG1335	isochorismatase
C4E26_RS11210	COG0583	DNA-binding transcription factor activity
C4E26_RS11215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E26_RS11215	COG1522	sequence-specific DNA binding
C4E26_RS11230	COG3964	amidohydrolase
C4E26_RS11240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS11245	COG2188	Transcriptional regulator
C4E26_RS11250	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E26_RS11255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS11260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4E26_RS11265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS11270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4E26_RS11285	COG1484	DNA-dependent DNA replication
C4E26_RS11310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4E26_RS11320	COG0305	Participates in initiation and elongation during chromosome replication
C4E26_RS11325	COG0359	binds to the 23S rRNA
C4E26_RS11330	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C4E26_RS11345	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4E26_RS11350	COG0629	single-stranded DNA binding
C4E26_RS11355	COG0360	Binds together with S18 to 16S ribosomal RNA
C4E26_RS11360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS11375	COG0425	Belongs to the sulfur carrier protein TusA family
C4E26_RS11390	COG1104	cysteine desulfurase activity
C4E26_RS11395	COG1475	DNA binding
C4E26_RS11400	COG1192	Involved in chromosome partitioning
C4E26_RS11405	COG1475	DNA binding
C4E26_RS11410	COG0357	Ribosomal RNA small subunit methyltransferase G
C4E26_RS11415	COG0445	tRNA wobble uridine modification
C4E26_RS11420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4E26_RS11425	COG1847	R3H domain protein
C4E26_RS11430	COG0706	membrane insertase activity
C4E26_RS11435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4E26_RS11440	COG0594	ribonuclease P activity
C4E26_RS11445	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4E26_RS11450	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4E26_RS11455	COG0592	DNA-directed DNA polymerase activity
C4E26_RS11465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4E26_RS11470	COG0187	DNA topoisomerase II activity
C4E26_RS11475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4E26_RS11490	COG1366	Belongs to the anti-sigma-factor antagonist family
C4E26_RS11500	COG1191	sigma factor activity
C4E26_RS11550	COG1827	regulation of RNA biosynthetic process
C4E26_RS11555	COG0668	transmembrane transport
C4E26_RS11560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4E26_RS11565	COG0590	tRNA wobble adenosine to inosine editing
C4E26_RS11580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4E26_RS11585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4E26_RS11590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4E26_RS11600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E26_RS11840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C4E26_RS11845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4E26_RS11850	COG4463	regulation of RNA biosynthetic process
C4E26_RS11855	COG3880	PFAM UvrB UvrC protein
C4E26_RS11860	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C4E26_RS11865	COG0542	response to heat
C4E26_RS11870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4E26_RS11875	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C4E26_RS11880	COG4956	integral membrane protein (PIN domain superfamily)
C4E26_RS11900	COG3507	Belongs to the glycosyl hydrolase 43 family
C4E26_RS11910	COG2205	protein histidine kinase activity
C4E26_RS11915	COG0745	RESPONSE REGULATOR receiver
C4E26_RS11925	COG2390	Transcriptional regulator
C4E26_RS11930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4E26_RS11935	COG0022	dehydrogenase e1 component
C4E26_RS11940	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4E26_RS11945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E26_RS11950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E26_RS11950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E26_RS11960	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E26_RS11965	COG3775	system Galactitol-specific IIC component
C4E26_RS11980	COG0095	Lipoate-protein ligase
C4E26_RS11985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4E26_RS11990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4E26_RS11995	COG0442	prolyl-tRNA aminoacylation
C4E26_RS12000	COG0442	prolyl-tRNA aminoacylation
C4E26_RS12005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4E26_RS12015	COG0215	cysteine-tRNA ligase activity
C4E26_RS12030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4E26_RS12035	COG3688	RNA-binding protein containing a PIN domain
C4E26_RS12045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4E26_RS12050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4E26_RS12060	COG0250	Participates in transcription elongation, termination and antitermination
C4E26_RS12065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4E26_RS12070	COG0081	regulation of translation
C4E26_RS12075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4E26_RS12080	COG0222	ribosome binding
C4E26_RS12090	COG0085	RNA polymerase activity
C4E26_RS12095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4E26_RS12100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4E26_RS12105	COG0049	tRNA binding
C4E26_RS12110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4E26_RS12115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4E26_RS12120	COG0051	transcription antitermination factor activity, RNA binding
C4E26_RS12125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4E26_RS12130	COG0088	Forms part of the polypeptide exit tunnel
C4E26_RS12135	COG0089	rRNA binding
C4E26_RS12140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4E26_RS12145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4E26_RS12150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4E26_RS12155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4E26_RS12160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4E26_RS12165	COG0255	Belongs to the universal ribosomal protein uL29 family
C4E26_RS12170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4E26_RS12175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4E26_RS12180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4E26_RS12185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4E26_RS12190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4E26_RS12195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4E26_RS12200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4E26_RS12205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4E26_RS12210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4E26_RS12215	COG1841	ribosomal large subunit assembly
C4E26_RS12220	COG0200	Binds to the 23S rRNA
C4E26_RS12230	COG0563	adenylate kinase activity
C4E26_RS12235	COG0024	Methionine aminopeptidase
C4E26_RS12245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4E26_RS12250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4E26_RS12255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4E26_RS12260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4E26_RS12265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4E26_RS12270	COG0202	RNA polymerase activity
C4E26_RS12275	COG0203	ribosomal protein L17
C4E26_RS12280	COG1122	ATPase activity
C4E26_RS12285	COG1122	ATPase activity
C4E26_RS12290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C4E26_RS12295	COG0101	tRNA pseudouridine synthase activity
C4E26_RS12300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4E26_RS12305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4E26_RS12310	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS12555	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C4E26_RS12570	COG0280	phosphate acetyltransferase
C4E26_RS12605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4E26_RS12610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4E26_RS12615	COG2897	thiosulfate sulfurtransferase activity
C4E26_RS12625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4E26_RS12630	COG2385	sporulation resulting in formation of a cellular spore
C4E26_RS12640	COG1609	Transcriptional regulator
C4E26_RS12645	COG1077	Cell shape determining protein MreB Mrl
C4E26_RS12650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4E26_RS12660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4E26_RS12665	COG3949	Membrane
C4E26_RS12670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4E26_RS12675	COG1040	competence protein
C4E26_RS12680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E26_RS12680	COG3711	transcriptional antiterminator
C4E26_RS12685	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E26_RS12690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS12695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS12705	COG1446	asparaginase
C4E26_RS12710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E26_RS12720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4E26_RS12725	COG0653	protein targeting
C4E26_RS12730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4E26_RS12735	COG2183	response to ionizing radiation
C4E26_RS12740	COG1228	amidohydrolase
C4E26_RS12755	COG0802	atpase or kinase
C4E26_RS12760	COG1214	PFAM Peptidase M22, glycoprotease
C4E26_RS12765	COG0456	acetyltransferase
C4E26_RS12770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4E26_RS12775	COG1882	Formate acetyltransferase
C4E26_RS12785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E26_RS12820	COG0534	Mate efflux family protein
C4E26_RS12825	COG0488	(ABC) transporter
C4E26_RS12830	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C4E26_RS12840	COG2221	Nitrite and sulphite reductase 4Fe-4S
C4E26_RS12850	COG1151	hydroxylamine reductase activity
C4E26_RS12910	COG0540	Belongs to the ATCase OTCase family
C4E26_RS12915	COG0543	2 iron, 2 sulfur cluster binding
C4E26_RS12920	COG0167	dihydroorotate dehydrogenase activity
C4E26_RS12925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4E26_RS12935	COG0583	DNA-binding transcription factor activity
C4E26_RS12950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4E26_RS12955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4E26_RS12960	COG0459	protein refolding
C4E26_RS12965	COG1691	(AIR) carboxylase
C4E26_RS12970	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C4E26_RS12975	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C4E26_RS12980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4E26_RS12980	COG0519	Catalyzes the synthesis of GMP from XMP
C4E26_RS13045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4E26_RS13050	COG2771	luxR family
C4E26_RS13050	COG2200	EAL domain
C4E26_RS13065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS13070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E26_RS13080	COG1011	Hydrolase
C4E26_RS13095	COG0778	Nitroreductase
C4E26_RS13100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4E26_RS13105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4E26_RS13110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4E26_RS13120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4E26_RS13125	COG0138	bifunctional purine biosynthesis protein purh
C4E26_RS13130	COG0151	Belongs to the GarS family
C4E26_RS13135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4E26_RS13145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4E26_RS13155	COG1088	dTDP-glucose 4,6-dehydratase activity
C4E26_RS13160	COG0741	lytic transglycosylase activity
C4E26_RS13195	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C4E26_RS13200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4E26_RS13215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4E26_RS13225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C4E26_RS13235	COG1215	transferase activity, transferring glycosyl groups
C4E26_RS13285	COG1454	alcohol dehydrogenase
C4E26_RS13290	COG1533	DNA photolyase activity
C4E26_RS13305	COG1733	regulation of RNA biosynthetic process
C4E26_RS13320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E26_RS13325	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E26_RS13325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E26_RS13330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E26_RS13330	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E26_RS13355	COG3716	PTS system mannose fructose sorbose family IID component
C4E26_RS13365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E26_RS13385	COG1131	(ABC) transporter
C4E26_RS13405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4E26_RS13415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E26_RS13420	COG1879	ABC-type sugar transport system periplasmic component
C4E26_RS13425	COG1129	ABC transporter
C4E26_RS13430	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E26_RS13435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E26_RS13445	COG1473	amidohydrolase
C4E26_RS13490	COG2217	Heavy metal translocating P-type atpase
C4E26_RS13510	COG0586	Pfam SNARE associated Golgi protein
C4E26_RS13530	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C4E26_RS13540	COG1122	ATPase activity
C4E26_RS13545	COG0210	DNA helicase
C4E26_RS13550	COG1362	aminopeptidase activity
C4E26_RS13560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4E26_RS13575	COG1454	alcohol dehydrogenase
C4E26_RS13575	COG1012	belongs to the aldehyde dehydrogenase family
C4E26_RS13585	COG1136	(ABC) transporter
C4E26_RS13620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4E26_RS13625	COG2357	RelA SpoT domain protein
C4E26_RS13645	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C4E26_RS13670	COG1263	PTS System
C4E26_RS13670	COG2190	(PTS) system
C4E26_RS13670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS13675	COG2723	6-phospho-beta-galactosidase activity
C4E26_RS13680	COG3711	transcriptional antiterminator
C4E26_RS13685	COG0367	asparagine synthase
C4E26_RS13700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4E26_RS13725	COG1960	acyl-CoA dehydrogenase activity
C4E26_RS13730	COG2086	electron transfer activity
C4E26_RS13735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E26_RS13740	COG3829	transcription factor binding
C4E26_RS13745	COG0191	fructose-bisphosphate aldolase activity
C4E26_RS13755	COG1187	pseudouridine synthase activity
C4E26_RS13820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E26_RS13825	COG0745	RESPONSE REGULATOR receiver
C4E26_RS13840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E26_RS13860	COG3254	rhamnose metabolic process
C4E26_RS13880	COG0626	cystathionine gamma-synthase activity
C4E26_RS13890	COG3829	transcription factor binding
C4E26_RS13895	COG3804	dihydrodipicolinate reductase
C4E26_RS13905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4E26_RS13915	COG5012	cobalamin binding
C4E26_RS13925	COG3457	Alanine racemase
C4E26_RS13930	COG1757	Na H antiporter
C4E26_RS13945	COG1051	belongs to the nudix hydrolase family
C4E26_RS13960	COG3973	AAA domain
C4E26_RS13970	COG1136	(ABC) transporter
C4E26_RS13980	COG5002	protein histidine kinase activity
C4E26_RS13985	COG0745	RESPONSE REGULATOR receiver
C4E26_RS14005	COG1131	(ABC) transporter
C4E26_RS14085	COG1595	DNA-templated transcription, initiation
C4E26_RS14170	COG0768	penicillin binding
C4E26_RS14195	COG1131	(ABC) transporter
C4E26_RS14210	COG0745	RESPONSE REGULATOR receiver
C4E26_RS14215	COG5002	protein histidine kinase activity
C4E26_RS14220	COG0577	efflux transmembrane transporter activity
C4E26_RS14220	COG1136	(ABC) transporter
C4E26_RS14225	COG1136	(ABC) transporter
C4E26_RS14230	COG5002	protein histidine kinase activity
C4E26_RS14235	COG0745	RESPONSE REGULATOR receiver
C4E26_RS14240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4E26_RS14255	COG1063	alcohol dehydrogenase
C4E26_RS14265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS14275	COG3716	PTS system mannose fructose sorbose family IID component
C4E26_RS14285	COG5002	protein histidine kinase activity
C4E26_RS14295	COG1686	Belongs to the peptidase S11 family
C4E26_RS14300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E26_RS14300	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E26_RS14320	COG2205	protein histidine kinase activity
C4E26_RS14345	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E26_RS14350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4E26_RS14370	COG2378	regulation of single-species biofilm formation
C4E26_RS14380	COG2201	protein-glutamate methylesterase activity
C4E26_RS14385	COG1776	CheC inhibitor of MCP methylation
C4E26_RS14390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4E26_RS14395	COG0835	chemotaxis
C4E26_RS14405	COG0840	transmembrane signaling receptor activity
C4E26_RS14410	COG2198	Histidine kinase
C4E26_RS14410	COG0643	Histidine kinase
C4E26_RS14415	COG0835	chemotaxis
C4E26_RS14425	COG2201	protein-glutamate methylesterase activity
C4E26_RS14475	COG2339	peptidase activity
C4E26_RS14480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4E26_RS14480	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C4E26_RS14485	COG0681	Belongs to the peptidase S26 family
C4E26_RS14500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4E26_RS14505	COG2066	Belongs to the glutaminase family
C4E26_RS14515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C4E26_RS14535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4E26_RS14540	COG1067	ATP-dependent peptidase activity
C4E26_RS14545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4E26_RS14550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4E26_RS14560	COG1744	ABC transporter substrate-binding protein PnrA-like
C4E26_RS14595	COG4399	Belongs to the UPF0754 family
C4E26_RS14595	COG4399	Belongs to the UPF0754 family
C4E26_RS14600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4E26_RS14645	COG1309	transcriptional regulator
C4E26_RS14660	COG5001	Diguanylate cyclase
C4E26_RS14660	COG1716	ATPase activity
C4E26_RS14665	COG2199	diguanylate cyclase activity
C4E26_RS14710	COG3969	phosphoadenosine phosphosulfate
C4E26_RS14715	COG1475	DNA binding
C4E26_RS14730	COG3546	catalase activity
C4E26_RS14740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4E26_RS14755	COG0456	acetyltransferase
C4E26_RS14755	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C4E26_RS14790	COG0789	Transcriptional regulator
C4E26_RS14790	COG4978	Transcriptional regulator
C4E26_RS14835	COG0305	Participates in initiation and elongation during chromosome replication
C4E26_RS14855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4E26_RS14915	COG1131	(ABC) transporter
C4E26_RS14925	COG1802	Transcriptional regulator
C4E26_RS14930	COG4946	Tricorn protease homolog
C4E26_RS14930	COG1506	peptidase
C4E26_RS14930	COG0823	Involved in the tonB-independent uptake of proteins
C4E26_RS14935	COG4946	Tricorn protease homolog
C4E26_RS14935	COG1506	peptidase
C4E26_RS14935	COG0823	Involved in the tonB-independent uptake of proteins
C4E26_RS14945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS14965	COG0038	chloride channel
C4E26_RS15050	COG0745	RESPONSE REGULATOR receiver
C4E26_RS15055	COG2205	protein histidine kinase activity
C4E26_RS15055	COG0745	RESPONSE REGULATOR receiver
C4E26_RS15055	COG3292	Two component regulator propeller
C4E26_RS15090	COG1595	DNA-templated transcription, initiation
C4E26_RS15100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4E26_RS15105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4E26_RS15110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4E26_RS15160	COG0789	Transcriptional regulator
C4E26_RS15180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4E26_RS15185	COG0569	domain protein
C4E26_RS15190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4E26_RS15195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4E26_RS15200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E26_RS15200	COG0072	phenylalanine-tRNA ligase activity
C4E26_RS15225	COG0826	peptidase U32
C4E26_RS15235	COG1051	belongs to the nudix hydrolase family
C4E26_RS15245	COG3706	GGDEF domain
C4E26_RS15250	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E26_RS15255	COG1193	negative regulation of DNA recombination
C4E26_RS15260	COG1683	Conserved Protein
C4E26_RS15265	COG0018	arginyl-trna synthetase
C4E26_RS15290	COG0583	DNA-binding transcription factor activity
C4E26_RS15295	COG0110	maltose O-acetyltransferase activity
C4E26_RS15300	COG0280	phosphate acetyltransferase
C4E26_RS15305	COG1151	hydroxylamine reductase activity
C4E26_RS15315	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C4E26_RS15320	COG3404	Formiminotransferase-cyclodeaminase
C4E26_RS15325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4E26_RS15335	COG0646	methionine synthase
C4E26_RS15335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4E26_RS15340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E26_RS15370	COG0509	glycine decarboxylation via glycine cleavage system
C4E26_RS15390	COG0095	Lipoate-protein ligase
C4E26_RS15410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E26_RS15425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4E26_RS15425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E26_RS15435	COG3192	ethanolamine utilization protein
C4E26_RS15440	COG1349	DNA-binding transcription factor activity
C4E26_RS15450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4E26_RS15455	COG1360	Flagellar Motor Protein
C4E26_RS15475	COG0210	DNA helicase
C4E26_RS15480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E26_RS15485	COG0765	amino acid transport
C4E26_RS15490	COG1126	abc transporter atp-binding protein
C4E26_RS15500	COG0301	tRNA thio-modification
C4E26_RS15510	COG0778	Nitroreductase
C4E26_RS15515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E26_RS15525	COG0530	calcium, potassium:sodium antiporter activity
C4E26_RS15530	COG0513	Belongs to the DEAD box helicase family
C4E26_RS15550	COG3732	PTS system glucitol sorbitol-specific
C4E26_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
C4E26_RS15570	COG0243	molybdopterin cofactor binding
C4E26_RS15575	COG1366	Belongs to the anti-sigma-factor antagonist family
C4E26_RS15580	COG2172	sigma factor antagonist activity
C4E26_RS15585	COG1191	sigma factor activity
C4E26_RS15595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4E26_RS15620	COG1473	amidohydrolase
C4E26_RS15630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4E26_RS15640	COG0750	zinc metalloprotease
C4E26_RS15650	COG0488	(ABC) transporter
C4E26_RS15665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4E26_RS15680	COG1739	Uncharacterized protein family UPF0029
C4E26_RS15690	COG0730	response to heat
C4E26_RS15695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4E26_RS15700	COG0217	transcriptional regulatory protein
C4E26_RS15705	COG1024	Enoyl-CoA hydratase
C4E26_RS15710	COG2610	gluconate transmembrane transporter activity
C4E26_RS15725	COG2086	electron transfer activity
C4E26_RS15730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E26_RS15775	COG2186	Transcriptional regulator
C4E26_RS15780	COG2814	Major facilitator Superfamily
C4E26_RS15785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E26_RS15785	COG2190	(PTS) system
C4E26_RS15785	COG1263	PTS System
C4E26_RS15790	COG2723	6-phospho-beta-galactosidase activity
C4E26_RS15800	COG0745	RESPONSE REGULATOR receiver
C4E26_RS15805	COG5002	protein histidine kinase activity
C4E26_RS15825	COG1592	Rubrerythrin
C4E26_RS15835	COG2033	superoxide reductase activity
C4E26_RS15840	COG0069	glutamate synthase activity
C4E26_RS15885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4E26_RS15895	COG0473	3-isopropylmalate dehydrogenase activity
C4E26_RS15900	COG1846	Transcriptional regulator
C4E26_RS15925	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4E26_RS15930	COG0138	bifunctional purine biosynthesis protein purh
C4E26_RS15940	COG0438	transferase activity, transferring glycosyl groups
C4E26_RS15940	COG0297	glycogen (starch) synthase activity
C4E26_RS16005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4E26_RS16020	COG0601	transmembrane transport
C4E26_RS16025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E26_RS16035	COG0444	Belongs to the ABC transporter superfamily
C4E26_RS16040	COG4608	Belongs to the ABC transporter superfamily
C4E26_RS16045	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C4E26_RS16045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E26_RS16060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E26_RS16070	COG1486	melibiose metabolic process
C4E26_RS16080	COG1073	alpha beta
C4E26_RS16090	COG1910	domain protein
C4E26_RS16095	COG0725	ABC transporter, periplasmic molybdate-binding protein
C4E26_RS16100	COG4149	molybdate abc transporter
C4E26_RS16105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4E26_RS16110	COG0110	maltose O-acetyltransferase activity
C4E26_RS16125	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4E26_RS16130	COG2984	ABC transporter substrate binding protein
C4E26_RS16140	COG4120	Belongs to the binding-protein-dependent transport system permease family
C4E26_RS16145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4E26_RS16145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4E26_RS16160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4E26_RS16165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4E26_RS16170	COG0297	glycogen (starch) synthase activity
C4E26_RS16175	COG0058	SHG alpha-glucan phosphorylase activity
C4E26_RS16185	COG1802	Transcriptional regulator
C4E26_RS16190	COG1982	Orn Lys Arg decarboxylase major
C4E26_RS16195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C4E26_RS16200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4E26_RS16205	COG0010	Belongs to the arginase family
C4E26_RS16240	COG4868	Belongs to the UPF0371 family
C4E26_RS16245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4E26_RS16255	COG1174	glycine betaine transport
C4E26_RS16260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4E26_RS16290	COG0534	Mate efflux family protein
C4E26_RS16295	COG0539	negative regulation of cytoplasmic translation
C4E26_RS16295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4E26_RS16300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E26_RS16310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4E26_RS16315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4E26_RS16320	COG0066	3-isopropylmalate dehydratase activity
C4E26_RS16325	COG0473	3-isopropylmalate dehydrogenase activity
C4E26_RS16340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4E26_RS16355	COG5001	Diguanylate cyclase
C4E26_RS16355	COG3447	MASE1 domain protein
C4E26_RS16355	COG5002	protein histidine kinase activity
C4E26_RS16380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4E26_RS16385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E26_RS16395	COG0281	malic enzyme
C4E26_RS16410	COG0745	RESPONSE REGULATOR receiver
C4E26_RS16415	COG5002	protein histidine kinase activity
C4E26_RS16420	COG0577	efflux transmembrane transporter activity
C4E26_RS16420	COG1136	(ABC) transporter
C4E26_RS16440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4E26_RS16445	COG0363	glucosamine-6-phosphate deaminase activity
C4E26_RS16460	COG5002	protein histidine kinase activity
C4E26_RS16465	COG5001	Diguanylate cyclase
C4E26_RS16475	COG4978	Transcriptional regulator
C4E26_RS16475	COG0789	Transcriptional regulator
C4E26_RS16485	COG1132	(ABC) transporter
C4E26_RS16505	COG2364	Membrane
C4E26_RS16515	COG3842	ATPase activity
C4E26_RS16520	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4E26_RS16525	COG1177	transmembrane transport
C4E26_RS16530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4E26_RS16540	COG5298	Protein conserved in bacteria
C4E26_RS16545	COG1215	transferase activity, transferring glycosyl groups
C4E26_RS16560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4E26_RS16590	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS16595	COG2247	cell wall binding repeat
C4E26_RS16595	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E26_RS16605	COG1074	ATP-dependent DNA helicase activity
C4E26_RS16615	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C4E26_RS16620	COG1074	ATP-dependent DNA helicase activity
C4E26_RS16625	COG0420	3'-5' exonuclease activity
C4E26_RS16630	COG0419	ATPase involved in DNA repair
C4E26_RS16635	COG4536	flavin adenine dinucleotide binding
C4E26_RS16645	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E26_RS16655	COG0622	Phosphoesterase
C4E26_RS16660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4E26_RS16665	COG1131	(ABC) transporter
C4E26_RS16685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4E26_RS16690	COG1960	acyl-CoA dehydrogenase activity
C4E26_RS16695	COG2086	electron transfer activity
C4E26_RS16700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E26_RS16715	COG0183	Belongs to the thiolase family
C4E26_RS16720	COG0564	pseudouridine synthase activity
C4E26_RS16730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4E26_RS16785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C4E26_RS16790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS16795	COG4224	UPF0291 protein
C4E26_RS16800	COG1362	aminopeptidase activity
C4E26_RS16805	COG2188	Transcriptional regulator
C4E26_RS16825	COG3715	PTS system
C4E26_RS16830	COG3716	PTS system mannose fructose sorbose family IID component
C4E26_RS16835	COG0583	DNA-binding transcription factor activity
C4E26_RS16855	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E26_RS16860	COG1132	(ABC) transporter
C4E26_RS16870	COG1473	amidohydrolase
C4E26_RS16885	COG3279	Response regulator of the LytR AlgR family
C4E26_RS16900	COG1882	Formate acetyltransferase
C4E26_RS16905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E26_RS16910	COG1396	sequence-specific DNA binding
C4E26_RS16935	COG2207	Transcriptional regulator
C4E26_RS16935	COG3708	Transcriptional regulator
C4E26_RS16970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4E26_RS16970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4E26_RS16975	COG0237	dephospho-CoA kinase activity
C4E26_RS17000	COG0346	lactoylglutathione lyase activity
C4E26_RS17005	COG0791	NLP P60 protein
C4E26_RS17015	COG4656	Part of a membrane complex involved in electron transport
C4E26_RS17020	COG4658	electron transport chain
C4E26_RS17025	COG4659	FMN binding
C4E26_RS17030	COG4660	Part of a membrane complex involved in electron transport
C4E26_RS17035	COG4657	Part of a membrane complex involved in electron transport
C4E26_RS17040	COG2878	Part of a membrane complex involved in electron transport
C4E26_RS17040	COG1245	4Fe-4S binding domain
C4E26_RS17045	COG0424	maF-like protein
C4E26_RS17050	COG2003	Belongs to the UPF0758 family
C4E26_RS17055	COG1077	Cell shape determining protein MreB Mrl
C4E26_RS17075	COG0850	regulation of cytokinetic process
C4E26_RS17080	COG2894	cell division
C4E26_RS17085	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4E26_RS17090	COG0772	Belongs to the SEDS family
C4E26_RS17095	COG1803	Methylglyoxal synthase
C4E26_RS17100	COG1695	Transcriptional regulator
C4E26_RS17115	COG0426	domain, Protein
C4E26_RS17130	COG1530	ribonuclease E activity
C4E26_RS17135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4E26_RS17145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4E26_RS17150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4E26_RS17160	COG0460	homoserine dehydrogenase
C4E26_RS17175	COG2186	Transcriptional regulator
C4E26_RS17180	COG3875	lactate racemase activity
C4E26_RS17185	COG2086	electron transfer activity
C4E26_RS17190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E26_RS17195	COG0277	FAD linked oxidase domain protein
C4E26_RS17200	COG1323	Belongs to the UPF0348 family
C4E26_RS17205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4E26_RS17215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4E26_RS17225	COG0416	fatty acid biosynthetic process
C4E26_RS17230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4E26_RS17240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4E26_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
C4E26_RS17250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4E26_RS17255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4E26_RS17260	COG3706	GGDEF domain
C4E26_RS17275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4E26_RS17290	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C4E26_RS17295	COG3854	ATPases associated with a variety of cellular activities
C4E26_RS17335	COG1302	Protein conserved in bacteria
C4E26_RS17340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4E26_RS17345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4E26_RS17350	COG1570	exodeoxyribonuclease VII activity
C4E26_RS17355	COG1722	exodeoxyribonuclease VII activity
C4E26_RS17365	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C4E26_RS17370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4E26_RS17375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4E26_RS17380	COG0497	DNA recombination
C4E26_RS17390	COG0456	acetyltransferase
C4E26_RS17395	COG0456	acetyltransferase
C4E26_RS17400	COG0750	zinc metalloprotease
C4E26_RS17435	COG0494	nUDIX hydrolase
C4E26_RS17445	COG4974	Belongs to the 'phage' integrase family
C4E26_RS17450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C4E26_RS17465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4E26_RS17470	COG4122	O-methyltransferase activity
C4E26_RS17475	COG0826	peptidase U32
C4E26_RS17480	COG0768	penicillin binding
C4E26_RS17595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4E26_RS17605	COG0571	ribonuclease III activity
C4E26_RS17615	COG1196	nuclear chromosome segregation
C4E26_RS17620	COG0552	protein localization to endoplasmic reticulum
C4E26_RS17630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4E26_RS17635	COG0228	four-way junction DNA binding
C4E26_RS17645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4E26_RS17650	COG0336	Belongs to the RNA methyltransferase TrmD family
C4E26_RS17655	COG0335	large ribosomal subunit rRNA binding
C4E26_RS17680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4E26_RS17710	COG1131	(ABC) transporter
C4E26_RS17715	COG2197	response regulator
C4E26_RS17720	COG4585	Histidine kinase
C4E26_RS17725	COG0792	nuclease activity
C4E26_RS17730	COG0606	chelatase, subunit chli
C4E26_RS17735	COG0758	DNA mediated transformation
C4E26_RS17740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E26_RS17750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4E26_RS17760	COG1959	2 iron, 2 sulfur cluster binding
C4E26_RS17770	COG0822	iron-sulfur transferase activity
C4E26_RS17775	COG0482	sulfurtransferase activity
C4E26_RS17780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4E26_RS17785	COG4472	Bacterial protein of unknown function (DUF965)
C4E26_RS17795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4E26_RS17800	COG3906	Belongs to the UPF0473 family
C4E26_RS17805	COG0735	belongs to the Fur family
C4E26_RS17815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C4E26_RS17825	COG1686	Belongs to the peptidase S11 family
C4E26_RS17835	COG1917	Cupin 2, conserved barrel domain protein
C4E26_RS17835	COG2207	Transcriptional regulator
C4E26_RS17840	COG1994	Peptidase M50
C4E26_RS17850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4E26_RS17905	COG0779	Required for maturation of 30S ribosomal subunits
C4E26_RS17910	COG0195	Participates in both transcription termination and antitermination
C4E26_RS17915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C4E26_RS17925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4E26_RS17935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4E26_RS17940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4E26_RS17945	COG0196	riboflavin kinase activity
C4E26_RS17955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4E26_RS17960	COG1307	EDD domain protein, DegV family
C4E26_RS17965	COG1185	polyribonucleotide nucleotidyltransferase activity
C4E26_RS17970	COG0726	polysaccharide deacetylase
C4E26_RS17975	COG0612	Peptidase, M16
C4E26_RS17980	COG1873	PFAM PRC-barrel domain
C4E26_RS17985	COG0527	aspartate kinase activity
C4E26_RS17990	COG0740	serine-type endopeptidase activity
C4E26_RS18000	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4E26_RS18005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4E26_RS18015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4E26_RS18020	COG1418	mRNA catabolic process
C4E26_RS18025	COG5001	Diguanylate cyclase
C4E26_RS18060	COG1968	undecaprenyl-diphosphatase activity
C4E26_RS18070	COG0114	fumarate hydratase activity
C4E26_RS18080	COG0436	Aminotransferase
C4E26_RS18090	COG0708	Exodeoxyribonuclease III
C4E26_RS18105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4E26_RS18130	COG1131	(ABC) transporter
C4E26_RS18160	COG1278	Cold shock
C4E26_RS18170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E26_RS18250	COG3299	homolog of phage Mu protein gp47
C4E26_RS18255	COG3778	Protein conserved in bacteria
C4E26_RS18285	COG1396	sequence-specific DNA binding
C4E26_RS18300	COG1396	sequence-specific DNA binding
C4E26_RS18305	COG2814	Major facilitator Superfamily
C4E26_RS18315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4E26_RS18320	COG0471	metal ion transport
C4E26_RS18320	COG3273	potassium ion transport
C4E26_RS18325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4E26_RS18330	COG1914	H( )-stimulated, divalent metal cation uptake system
C4E26_RS18335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4E26_RS18340	COG1984	allophanate hydrolase subunit 2
C4E26_RS18345	COG1396	sequence-specific DNA binding
C4E26_RS18350	COG4948	Mandelate Racemase Muconate Lactonizing
C4E26_RS18400	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4E26_RS18415	COG0584	glycerophosphoryl diester phosphodiesterase
C4E26_RS18460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS18465	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4E26_RS18470	COG1546	Belongs to the CinA family
C4E26_RS18470	COG1058	Belongs to the CinA family
C4E26_RS18485	COG3829	transcription factor binding
C4E26_RS18495	COG1242	4 iron, 4 sulfur cluster binding
C4E26_RS18520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4E26_RS18525	COG3447	MASE1 domain protein
C4E26_RS18525	COG5001	Diguanylate cyclase
C4E26_RS18525	COG5002	protein histidine kinase activity
C4E26_RS18530	COG2199	diguanylate cyclase activity
C4E26_RS18530	COG2203	Gaf domain
C4E26_RS18540	COG4978	Transcriptional regulator
C4E26_RS18540	COG0789	Transcriptional regulator
C4E26_RS18550	COG1285	pathogenesis
C4E26_RS18565	COG0726	polysaccharide deacetylase
C4E26_RS18580	COG0450	alkyl hydroperoxide reductase
C4E26_RS18595	COG2720	vancomycin resistance protein
C4E26_RS18600	COG3829	transcription factor binding
C4E26_RS18615	COG1346	cytolysis
C4E26_RS18620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4E26_RS18630	COG2340	Cysteine-rich secretory protein family
C4E26_RS18635	COG0726	polysaccharide deacetylase
C4E26_RS18640	COG0512	Glutamine amidotransferase of anthranilate synthase
C4E26_RS18645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4E26_RS18650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4E26_RS18660	COG0302	gtp cyclohydrolase
C4E26_RS18665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4E26_RS18670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4E26_RS18675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4E26_RS18680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4E26_RS18685	COG0358	DNA primase activity
C4E26_RS18690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4E26_RS18695	COG2384	SAM-dependent methyltransferase
C4E26_RS18700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4E26_RS18705	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4E26_RS18725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E26_RS18735	COG0745	RESPONSE REGULATOR receiver
C4E26_RS18740	COG3850	Histidine kinase
C4E26_RS18740	COG5002	protein histidine kinase activity
C4E26_RS18745	COG1136	(ABC) transporter
C4E26_RS18745	COG0577	efflux transmembrane transporter activity
C4E26_RS18775	COG1132	(ABC) transporter
C4E26_RS18780	COG1132	(ABC) transporter
C4E26_RS18785	COG1592	Rubrerythrin
C4E26_RS18785	COG1773	rubredoxin
C4E26_RS18790	COG0412	Dienelactone hydrolase
C4E26_RS18830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E26_RS18865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4E26_RS18870	COG2011	ABC-type metal ion transport system permease component
C4E26_RS18875	COG1464	Belongs to the NlpA lipoprotein family
C4E26_RS18880	COG5002	protein histidine kinase activity
C4E26_RS18885	COG2094	Belongs to the DNA glycosylase MPG family
C4E26_RS18890	COG1396	sequence-specific DNA binding
C4E26_RS18895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4E26_RS18900	COG4086	secreted protein
C4E26_RS18920	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4E26_RS18925	COG1121	(ABC) transporter
C4E26_RS18930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4E26_RS18935	COG0523	cobalamin synthesis protein
C4E26_RS18940	COG0701	Predicted permease
C4E26_RS18955	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4E26_RS18965	COG1131	(ABC) transporter
C4E26_RS18975	COG0534	Mate efflux family protein
C4E26_RS18990	COG3901	Regulator of nitric oxide reductase transcription
C4E26_RS18990	COG0348	domain, Protein
C4E26_RS19015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4E26_RS19020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4E26_RS19030	COG5001	Diguanylate cyclase
C4E26_RS19035	COG0789	Transcriptional regulator
C4E26_RS19035	COG4978	Transcriptional regulator
C4E26_RS19040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C4E26_RS19060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4E26_RS19065	COG0726	polysaccharide deacetylase
C4E26_RS19075	COG1773	rubredoxin
C4E26_RS19075	COG1592	Rubrerythrin
C4E26_RS19080	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E26_RS19085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4E26_RS19090	COG0577	efflux transmembrane transporter activity
C4E26_RS19095	COG0577	efflux transmembrane transporter activity
C4E26_RS19095	COG1136	(ABC) transporter
C4E26_RS19105	COG2205	protein histidine kinase activity
C4E26_RS19110	COG0745	RESPONSE REGULATOR receiver
C4E26_RS19115	COG1136	(ABC) transporter
C4E26_RS19120	COG0577	efflux transmembrane transporter activity
C4E26_RS19140	COG1674	ftsk spoiiie
C4E26_RS19150	COG2946	Replication initiation factor