locus-tag	class	description
CWR56_RS00010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWR56_RS00020	COG0250	Participates in transcription elongation, termination and antitermination
CWR56_RS00025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWR56_RS00030	COG0081	regulation of translation
CWR56_RS00035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWR56_RS00040	COG0222	ribosome binding
CWR56_RS00050	COG0085	RNA polymerase activity
CWR56_RS00055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWR56_RS00060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWR56_RS00065	COG0049	tRNA binding
CWR56_RS00070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWR56_RS00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWR56_RS00080	COG0051	transcription antitermination factor activity, RNA binding
CWR56_RS00085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWR56_RS00090	COG0088	Forms part of the polypeptide exit tunnel
CWR56_RS00095	COG0089	rRNA binding
CWR56_RS00100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWR56_RS00105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWR56_RS00110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWR56_RS00115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWR56_RS00120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWR56_RS00125	COG0255	Belongs to the universal ribosomal protein uL29 family
CWR56_RS00130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWR56_RS00135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWR56_RS00140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWR56_RS00145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWR56_RS00150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWR56_RS00155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWR56_RS00160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWR56_RS00165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWR56_RS00170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWR56_RS00175	COG1841	ribosomal large subunit assembly
CWR56_RS00180	COG0200	Binds to the 23S rRNA
CWR56_RS00190	COG0563	adenylate kinase activity
CWR56_RS00195	COG0024	Methionine aminopeptidase
CWR56_RS00205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWR56_RS00210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWR56_RS00215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWR56_RS00220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CWR56_RS00225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWR56_RS00230	COG0202	RNA polymerase activity
CWR56_RS00235	COG0203	ribosomal protein L17
CWR56_RS00240	COG1122	ATPase activity
CWR56_RS00245	COG1122	ATPase activity
CWR56_RS00250	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWR56_RS00255	COG0101	tRNA pseudouridine synthase activity
CWR56_RS00260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWR56_RS00265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWR56_RS00270	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS00515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CWR56_RS00530	COG0280	phosphate acetyltransferase
CWR56_RS00565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWR56_RS00570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWR56_RS00575	COG2897	thiosulfate sulfurtransferase activity
CWR56_RS00585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWR56_RS00590	COG2385	sporulation resulting in formation of a cellular spore
CWR56_RS00600	COG1609	Transcriptional regulator
CWR56_RS00605	COG1077	Cell shape determining protein MreB Mrl
CWR56_RS00610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWR56_RS00620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWR56_RS00625	COG3949	Membrane
CWR56_RS00630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWR56_RS00635	COG1040	competence protein
CWR56_RS00640	COG3711	transcriptional antiterminator
CWR56_RS00640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS00645	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWR56_RS00650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS00655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS00665	COG1446	asparaginase
CWR56_RS00670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR56_RS00680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWR56_RS00685	COG0653	protein targeting
CWR56_RS00695	COG2183	response to ionizing radiation
CWR56_RS00700	COG1228	amidohydrolase
CWR56_RS00715	COG0802	atpase or kinase
CWR56_RS00720	COG1214	PFAM Peptidase M22, glycoprotease
CWR56_RS00725	COG0456	acetyltransferase
CWR56_RS00730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWR56_RS00735	COG1882	Formate acetyltransferase
CWR56_RS00745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CWR56_RS00765	COG1136	(ABC) transporter
CWR56_RS00780	COG0745	RESPONSE REGULATOR receiver
CWR56_RS00785	COG5002	protein histidine kinase activity
CWR56_RS00790	COG0577	efflux transmembrane transporter activity
CWR56_RS00790	COG1136	(ABC) transporter
CWR56_RS00810	COG1473	amidohydrolase
CWR56_RS00830	COG0534	Mate efflux family protein
CWR56_RS00835	COG0488	(ABC) transporter
CWR56_RS00840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CWR56_RS00850	COG2221	Nitrite and sulphite reductase 4Fe-4S
CWR56_RS00860	COG1151	hydroxylamine reductase activity
CWR56_RS00875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CWR56_RS00915	COG0540	Belongs to the ATCase OTCase family
CWR56_RS00920	COG0543	2 iron, 2 sulfur cluster binding
CWR56_RS00925	COG0167	dihydroorotate dehydrogenase activity
CWR56_RS00930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CWR56_RS00940	COG0583	DNA-binding transcription factor activity
CWR56_RS00955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWR56_RS00960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWR56_RS00965	COG0459	protein refolding
CWR56_RS00970	COG1691	(AIR) carboxylase
CWR56_RS00975	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CWR56_RS00980	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CWR56_RS00985	COG0519	Catalyzes the synthesis of GMP from XMP
CWR56_RS00985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWR56_RS01015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWR56_RS01020	COG2200	EAL domain
CWR56_RS01020	COG2771	luxR family
CWR56_RS01035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS01040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS01050	COG1011	Hydrolase
CWR56_RS01075	COG0778	Nitroreductase
CWR56_RS01080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWR56_RS01085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWR56_RS01090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CWR56_RS01095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWR56_RS01100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CWR56_RS01105	COG0138	bifunctional purine biosynthesis protein purh
CWR56_RS01110	COG0151	Belongs to the GarS family
CWR56_RS01115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWR56_RS01125	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CWR56_RS01140	COG0741	lytic transglycosylase activity
CWR56_RS01175	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CWR56_RS01180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CWR56_RS01195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CWR56_RS01205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWR56_RS01215	COG0463	Glycosyl transferase, family 2
CWR56_RS01250	COG4786	Flagellar basal body rod
CWR56_RS01260	COG1677	Flagellar hook-basal body complex protein FliE
CWR56_RS01265	COG1766	The M ring may be actively involved in energy transduction
CWR56_RS01270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWR56_RS01280	COG1157	protein secretion by the type III secretion system
CWR56_RS01295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CWR56_RS01300	COG4786	Flagellar basal body rod
CWR56_RS01315	COG1360	Flagellar Motor Protein
CWR56_RS01330	COG1338	Plays a role in the flagellum-specific transport system
CWR56_RS01340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWR56_RS01345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWR56_RS01350	COG1419	protein localization to endoplasmic reticulum
CWR56_RS01360	COG1191	sigma factor activity
CWR56_RS01375	COG4786	Flagellar basal body rod
CWR56_RS01390	COG1776	CheC inhibitor of MCP methylation
CWR56_RS01390	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWR56_RS01405	COG1454	alcohol dehydrogenase
CWR56_RS01410	COG1533	DNA photolyase activity
CWR56_RS01425	COG1733	regulation of RNA biosynthetic process
CWR56_RS01445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWR56_RS01450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWR56_RS01450	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CWR56_RS01455	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CWR56_RS01455	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWR56_RS01480	COG3716	PTS system mannose fructose sorbose family IID component
CWR56_RS01490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR56_RS01500	COG3620	sequence-specific DNA binding
CWR56_RS01510	COG1131	(ABC) transporter
CWR56_RS01530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWR56_RS01535	COG1609	Transcriptional regulator
CWR56_RS01540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWR56_RS01545	COG1879	ABC-type sugar transport system periplasmic component
CWR56_RS01550	COG1129	ABC transporter
CWR56_RS01555	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWR56_RS01560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR56_RS01570	COG1473	amidohydrolase
CWR56_RS01615	COG2217	Heavy metal translocating P-type atpase
CWR56_RS01635	COG0586	Pfam SNARE associated Golgi protein
CWR56_RS01670	COG2205	protein histidine kinase activity
CWR56_RS01675	COG0745	RESPONSE REGULATOR receiver
CWR56_RS01710	COG1122	ATPase activity
CWR56_RS01715	COG0210	DNA helicase
CWR56_RS01720	COG1362	aminopeptidase activity
CWR56_RS01730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWR56_RS01745	COG1012	belongs to the aldehyde dehydrogenase family
CWR56_RS01745	COG1454	alcohol dehydrogenase
CWR56_RS01755	COG1136	(ABC) transporter
CWR56_RS01765	COG3290	protein histidine kinase activity
CWR56_RS01795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWR56_RS01800	COG2357	RelA SpoT domain protein
CWR56_RS01820	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CWR56_RS01845	COG1263	PTS System
CWR56_RS01845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS01845	COG2190	(PTS) system
CWR56_RS01850	COG2723	6-phospho-beta-galactosidase activity
CWR56_RS01855	COG3711	transcriptional antiterminator
CWR56_RS01865	COG0367	asparagine synthase
CWR56_RS01880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWR56_RS01905	COG1960	acyl-CoA dehydrogenase activity
CWR56_RS01910	COG2086	electron transfer activity
CWR56_RS01915	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWR56_RS01920	COG3829	transcription factor binding
CWR56_RS01925	COG0191	fructose-bisphosphate aldolase activity
CWR56_RS01935	COG1187	pseudouridine synthase activity
CWR56_RS01950	COG0210	DNA helicase
CWR56_RS01960	COG2946	Replication initiation factor
CWR56_RS01975	COG1002	Type II restriction enzyme, methylase subunits
CWR56_RS02030	COG3829	transcription factor binding
CWR56_RS02035	COG3804	dihydrodipicolinate reductase
CWR56_RS02045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWR56_RS02055	COG5012	cobalamin binding
CWR56_RS02065	COG3457	Alanine racemase
CWR56_RS02070	COG1757	Na H antiporter
CWR56_RS02090	COG3973	AAA domain
CWR56_RS02100	COG1136	(ABC) transporter
CWR56_RS02110	COG5002	protein histidine kinase activity
CWR56_RS02115	COG0745	RESPONSE REGULATOR receiver
CWR56_RS02120	COG1309	transcriptional regulator
CWR56_RS02135	COG1737	Transcriptional regulator
CWR56_RS02145	COG0561	phosphatase activity
CWR56_RS02150	COG0366	Alpha amylase catalytic
CWR56_RS02155	COG2190	(PTS) system
CWR56_RS02155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS02155	COG1263	PTS System
CWR56_RS02170	COG0655	NAD(P)H dehydrogenase (quinone) activity
CWR56_RS02200	COG1131	(ABC) transporter
CWR56_RS02220	COG5002	protein histidine kinase activity
CWR56_RS02225	COG1136	(ABC) transporter
CWR56_RS02225	COG0577	efflux transmembrane transporter activity
CWR56_RS02230	COG1136	(ABC) transporter
CWR56_RS02245	COG0745	RESPONSE REGULATOR receiver
CWR56_RS02250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWR56_RS02265	COG1063	alcohol dehydrogenase
CWR56_RS02275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS02285	COG3716	PTS system mannose fructose sorbose family IID component
CWR56_RS02305	COG3279	Response regulator of the LytR AlgR family
CWR56_RS02320	COG0535	radical SAM domain protein
CWR56_RS02325	COG0641	radical SAM
CWR56_RS02345	COG1136	(ABC) transporter
CWR56_RS02355	COG1686	Belongs to the peptidase S11 family
CWR56_RS02360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWR56_RS02360	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CWR56_RS02380	COG2205	protein histidine kinase activity
CWR56_RS02405	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWR56_RS02410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CWR56_RS02435	COG2378	regulation of single-species biofilm formation
CWR56_RS02445	COG2201	protein-glutamate methylesterase activity
CWR56_RS02450	COG1776	CheC inhibitor of MCP methylation
CWR56_RS02455	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CWR56_RS02460	COG0835	chemotaxis
CWR56_RS02470	COG0840	transmembrane signaling receptor activity
CWR56_RS02475	COG2198	Histidine kinase
CWR56_RS02475	COG0643	Histidine kinase
CWR56_RS02480	COG0835	chemotaxis
CWR56_RS02490	COG2201	protein-glutamate methylesterase activity
CWR56_RS02540	COG2339	peptidase activity
CWR56_RS02545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWR56_RS02545	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CWR56_RS02550	COG0681	Belongs to the peptidase S26 family
CWR56_RS02565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWR56_RS02570	COG2066	Belongs to the glutaminase family
CWR56_RS02580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CWR56_RS02600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWR56_RS02605	COG1067	ATP-dependent peptidase activity
CWR56_RS02610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWR56_RS02615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CWR56_RS02625	COG1744	ABC transporter substrate-binding protein PnrA-like
CWR56_RS02650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWR56_RS02690	COG1309	transcriptional regulator
CWR56_RS02695	COG3848	Pyruvate phosphate dikinase
CWR56_RS02695	COG0574	Belongs to the PEP-utilizing enzyme family
CWR56_RS02710	COG3706	GGDEF domain
CWR56_RS02770	COG3969	phosphoadenosine phosphosulfate
CWR56_RS02775	COG1475	DNA binding
CWR56_RS02790	COG3546	catalase activity
CWR56_RS02805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWR56_RS02830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CWR56_RS02870	COG3279	Response regulator of the LytR AlgR family
CWR56_RS02875	COG0577	efflux transmembrane transporter activity
CWR56_RS02880	COG1136	(ABC) transporter
CWR56_RS02900	COG4978	Transcriptional regulator
CWR56_RS02900	COG0789	Transcriptional regulator
CWR56_RS02945	COG0305	Participates in initiation and elongation during chromosome replication
CWR56_RS02965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWR56_RS02970	COG0534	Mate efflux family protein
CWR56_RS02980	COG4335	DNA alkylation repair
CWR56_RS03035	COG0745	RESPONSE REGULATOR receiver
CWR56_RS03040	COG2205	protein histidine kinase activity
CWR56_RS03045	COG1131	(ABC) transporter
CWR56_RS03060	COG1802	Transcriptional regulator
CWR56_RS03065	COG1506	peptidase
CWR56_RS03065	COG0823	Involved in the tonB-independent uptake of proteins
CWR56_RS03065	COG4946	Tricorn protease homolog
CWR56_RS03070	COG1506	peptidase
CWR56_RS03070	COG0823	Involved in the tonB-independent uptake of proteins
CWR56_RS03070	COG4946	Tricorn protease homolog
CWR56_RS03090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS03110	COG0038	chloride channel
CWR56_RS03190	COG2205	protein histidine kinase activity
CWR56_RS03225	COG1595	DNA-templated transcription, initiation
CWR56_RS03240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CWR56_RS03260	COG2814	Major facilitator Superfamily
CWR56_RS03265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWR56_RS03270	COG1609	Transcriptional regulator
CWR56_RS03285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWR56_RS03290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWR56_RS03325	COG0789	Transcriptional regulator
CWR56_RS03345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWR56_RS03350	COG0569	domain protein
CWR56_RS03355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWR56_RS03360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWR56_RS03365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR56_RS03365	COG0072	phenylalanine-tRNA ligase activity
CWR56_RS03380	COG0826	peptidase U32
CWR56_RS03390	COG1051	belongs to the nudix hydrolase family
CWR56_RS03400	COG3706	GGDEF domain
CWR56_RS03405	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWR56_RS03410	COG1193	negative regulation of DNA recombination
CWR56_RS03415	COG1683	Conserved Protein
CWR56_RS03420	COG0018	arginyl-trna synthetase
CWR56_RS03435	COG1032	radical SAM domain protein
CWR56_RS03450	COG0583	DNA-binding transcription factor activity
CWR56_RS03460	COG0280	phosphate acetyltransferase
CWR56_RS03465	COG1151	hydroxylamine reductase activity
CWR56_RS03475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CWR56_RS03480	COG3404	Formiminotransferase-cyclodeaminase
CWR56_RS03485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWR56_RS03495	COG0646	methionine synthase
CWR56_RS03495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CWR56_RS03500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR56_RS03530	COG0509	glycine decarboxylation via glycine cleavage system
CWR56_RS03550	COG0095	Lipoate-protein ligase
CWR56_RS03570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWR56_RS03585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CWR56_RS03585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR56_RS03595	COG3192	ethanolamine utilization protein
CWR56_RS03600	COG1349	DNA-binding transcription factor activity
CWR56_RS03610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CWR56_RS03615	COG1360	Flagellar Motor Protein
CWR56_RS03635	COG0210	DNA helicase
CWR56_RS03640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR56_RS03645	COG0765	amino acid transport
CWR56_RS03650	COG1126	abc transporter atp-binding protein
CWR56_RS03660	COG0301	tRNA thio-modification
CWR56_RS03670	COG0778	Nitroreductase
CWR56_RS03675	COG5001	Diguanylate cyclase
CWR56_RS03675	COG3300	MHYT domain
CWR56_RS03680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CWR56_RS03690	COG0530	calcium, potassium:sodium antiporter activity
CWR56_RS03695	COG0513	Belongs to the DEAD box helicase family
CWR56_RS03715	COG3732	PTS system glucitol sorbitol-specific
CWR56_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
CWR56_RS03735	COG0243	molybdopterin cofactor binding
CWR56_RS03740	COG1366	Belongs to the anti-sigma-factor antagonist family
CWR56_RS03745	COG2172	sigma factor antagonist activity
CWR56_RS03750	COG1191	sigma factor activity
CWR56_RS03760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWR56_RS03785	COG1473	amidohydrolase
CWR56_RS03795	COG2226	methyltransferase
CWR56_RS03810	COG0295	cytidine deaminase activity
CWR56_RS03815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWR56_RS03825	COG0750	zinc metalloprotease
CWR56_RS03830	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS03835	COG0488	(ABC) transporter
CWR56_RS03850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWR56_RS03865	COG1739	Uncharacterized protein family UPF0029
CWR56_RS03875	COG0730	response to heat
CWR56_RS03880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CWR56_RS03885	COG0217	transcriptional regulatory protein
CWR56_RS03895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWR56_RS03910	COG1024	Enoyl-CoA hydratase
CWR56_RS03915	COG2610	gluconate transmembrane transporter activity
CWR56_RS03930	COG2086	electron transfer activity
CWR56_RS03935	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWR56_RS03965	COG3300	MHYT domain
CWR56_RS03965	COG5001	Diguanylate cyclase
CWR56_RS03980	COG2186	Transcriptional regulator
CWR56_RS03985	COG2814	Major facilitator Superfamily
CWR56_RS03990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS03990	COG2190	(PTS) system
CWR56_RS03990	COG1263	PTS System
CWR56_RS04005	COG2723	6-phospho-beta-galactosidase activity
CWR56_RS04015	COG0745	RESPONSE REGULATOR receiver
CWR56_RS04020	COG2205	protein histidine kinase activity
CWR56_RS04040	COG1592	Rubrerythrin
CWR56_RS04050	COG2033	superoxide reductase activity
CWR56_RS04055	COG0069	glutamate synthase activity
CWR56_RS04075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWR56_RS04085	COG0473	3-isopropylmalate dehydrogenase activity
CWR56_RS04090	COG1846	Transcriptional regulator
CWR56_RS04115	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR56_RS04120	COG0138	bifunctional purine biosynthesis protein purh
CWR56_RS04130	COG0297	glycogen (starch) synthase activity
CWR56_RS04130	COG0438	transferase activity, transferring glycosyl groups
CWR56_RS04140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWR56_RS04145	COG3620	sequence-specific DNA binding
CWR56_RS04175	COG1473	amidohydrolase
CWR56_RS04180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CWR56_RS04195	COG0601	transmembrane transport
CWR56_RS04200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR56_RS04210	COG0444	Belongs to the ABC transporter superfamily
CWR56_RS04215	COG4608	Belongs to the ABC transporter superfamily
CWR56_RS04220	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CWR56_RS04220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWR56_RS04235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS04245	COG1486	melibiose metabolic process
CWR56_RS04255	COG1073	alpha beta
CWR56_RS04265	COG1910	domain protein
CWR56_RS04270	COG0725	ABC transporter, periplasmic molybdate-binding protein
CWR56_RS04275	COG4149	molybdate abc transporter
CWR56_RS04280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CWR56_RS04285	COG0110	maltose O-acetyltransferase activity
CWR56_RS04295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWR56_RS04300	COG4120	Belongs to the binding-protein-dependent transport system permease family
CWR56_RS04305	COG2984	ABC transporter substrate binding protein
CWR56_RS04315	COG4120	Belongs to the binding-protein-dependent transport system permease family
CWR56_RS04320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWR56_RS04320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CWR56_RS04335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CWR56_RS04340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CWR56_RS04345	COG0297	glycogen (starch) synthase activity
CWR56_RS04350	COG0058	SHG alpha-glucan phosphorylase activity
CWR56_RS04360	COG1802	Transcriptional regulator
CWR56_RS04365	COG1982	Orn Lys Arg decarboxylase major
CWR56_RS04370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWR56_RS04375	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWR56_RS04380	COG0010	Belongs to the arginase family
CWR56_RS04415	COG4868	Belongs to the UPF0371 family
CWR56_RS04420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWR56_RS04430	COG1174	glycine betaine transport
CWR56_RS04435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWR56_RS04465	COG0534	Mate efflux family protein
CWR56_RS04470	COG0539	negative regulation of cytoplasmic translation
CWR56_RS04470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWR56_RS04475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWR56_RS04485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWR56_RS04490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWR56_RS04495	COG0066	3-isopropylmalate dehydratase activity
CWR56_RS04500	COG0473	3-isopropylmalate dehydrogenase activity
CWR56_RS04515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWR56_RS04530	COG5001	Diguanylate cyclase
CWR56_RS04530	COG5002	protein histidine kinase activity
CWR56_RS04530	COG3447	MASE1 domain protein
CWR56_RS04555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CWR56_RS04560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CWR56_RS04570	COG0281	malic enzyme
CWR56_RS04595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWR56_RS04600	COG0363	glucosamine-6-phosphate deaminase activity
CWR56_RS04615	COG5002	protein histidine kinase activity
CWR56_RS04620	COG5001	Diguanylate cyclase
CWR56_RS04630	COG4978	Transcriptional regulator
CWR56_RS04630	COG0789	Transcriptional regulator
CWR56_RS04640	COG1132	(ABC) transporter
CWR56_RS04660	COG2364	Membrane
CWR56_RS04670	COG3842	ATPase activity
CWR56_RS04675	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWR56_RS04680	COG1177	transmembrane transport
CWR56_RS04685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CWR56_RS04695	COG5298	Protein conserved in bacteria
CWR56_RS04700	COG1215	transferase activity, transferring glycosyl groups
CWR56_RS04715	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWR56_RS04745	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS04750	COG2247	cell wall binding repeat
CWR56_RS04750	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS04760	COG0210	DNA helicase
CWR56_RS04770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CWR56_RS04775	COG1074	ATP-dependent DNA helicase activity
CWR56_RS04780	COG0420	3'-5' exonuclease activity
CWR56_RS04785	COG0419	ATPase involved in DNA repair
CWR56_RS04790	COG4536	flavin adenine dinucleotide binding
CWR56_RS04800	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWR56_RS04810	COG0622	Phosphoesterase
CWR56_RS04815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWR56_RS04820	COG1131	(ABC) transporter
CWR56_RS04840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CWR56_RS04845	COG1960	acyl-CoA dehydrogenase activity
CWR56_RS04850	COG2086	electron transfer activity
CWR56_RS04855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWR56_RS04870	COG0183	Belongs to the thiolase family
CWR56_RS04875	COG0564	pseudouridine synthase activity
CWR56_RS04885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWR56_RS04940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWR56_RS04945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS04950	COG4224	UPF0291 protein
CWR56_RS04955	COG1362	aminopeptidase activity
CWR56_RS04960	COG2188	Transcriptional regulator
CWR56_RS04980	COG3715	PTS system
CWR56_RS04985	COG3716	PTS system mannose fructose sorbose family IID component
CWR56_RS04990	COG0583	DNA-binding transcription factor activity
CWR56_RS05010	COG3414	Phosphotransferase system galactitol-specific IIB component
CWR56_RS05015	COG1132	(ABC) transporter
CWR56_RS05025	COG1473	amidohydrolase
CWR56_RS05040	COG3279	Response regulator of the LytR AlgR family
CWR56_RS05055	COG1882	Formate acetyltransferase
CWR56_RS05060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CWR56_RS05065	COG1396	sequence-specific DNA binding
CWR56_RS05090	COG3708	Transcriptional regulator
CWR56_RS05090	COG2207	Transcriptional regulator
CWR56_RS05110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWR56_RS05110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWR56_RS05115	COG0237	dephospho-CoA kinase activity
CWR56_RS05140	COG0346	lactoylglutathione lyase activity
CWR56_RS05145	COG0791	NLP P60 protein
CWR56_RS05155	COG4656	Part of a membrane complex involved in electron transport
CWR56_RS05160	COG4658	electron transport chain
CWR56_RS05165	COG4659	FMN binding
CWR56_RS05170	COG4660	Part of a membrane complex involved in electron transport
CWR56_RS05175	COG4657	Part of a membrane complex involved in electron transport
CWR56_RS05180	COG2878	Part of a membrane complex involved in electron transport
CWR56_RS05180	COG1245	4Fe-4S binding domain
CWR56_RS05185	COG0424	maF-like protein
CWR56_RS05190	COG2003	Belongs to the UPF0758 family
CWR56_RS05195	COG1077	Cell shape determining protein MreB Mrl
CWR56_RS05215	COG0850	regulation of cytokinetic process
CWR56_RS05220	COG2894	cell division
CWR56_RS05225	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CWR56_RS05230	COG0772	Belongs to the SEDS family
CWR56_RS05235	COG1803	Methylglyoxal synthase
CWR56_RS05240	COG1695	Transcriptional regulator
CWR56_RS05255	COG0426	domain, Protein
CWR56_RS05275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWR56_RS05285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWR56_RS05290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWR56_RS05300	COG0460	homoserine dehydrogenase
CWR56_RS05310	COG3314	Sporulation integral membrane protein YlbJ
CWR56_RS05315	COG2186	Transcriptional regulator
CWR56_RS05320	COG3875	lactate racemase activity
CWR56_RS05325	COG2086	electron transfer activity
CWR56_RS05330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWR56_RS05335	COG0277	FAD linked oxidase domain protein
CWR56_RS05340	COG1323	Belongs to the UPF0348 family
CWR56_RS05345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWR56_RS05355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWR56_RS05365	COG0416	fatty acid biosynthetic process
CWR56_RS05370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWR56_RS05380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWR56_RS05385	COG1028	Short-chain dehydrogenase reductase Sdr
CWR56_RS05390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWR56_RS05395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWR56_RS05400	COG3706	GGDEF domain
CWR56_RS05415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CWR56_RS05430	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CWR56_RS05435	COG3854	ATPases associated with a variety of cellular activities
CWR56_RS05475	COG1302	Protein conserved in bacteria
CWR56_RS05480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWR56_RS05485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWR56_RS05490	COG1570	exodeoxyribonuclease VII activity
CWR56_RS05505	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CWR56_RS05510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWR56_RS05515	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CWR56_RS05520	COG0497	DNA recombination
CWR56_RS05530	COG0456	acetyltransferase
CWR56_RS05535	COG0456	acetyltransferase
CWR56_RS05540	COG0750	zinc metalloprotease
CWR56_RS05560	COG0463	Glycosyl transferase, family 2
CWR56_RS05575	COG0494	nUDIX hydrolase
CWR56_RS05585	COG4974	Belongs to the 'phage' integrase family
CWR56_RS05590	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CWR56_RS05595	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CWR56_RS05605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWR56_RS05610	COG4122	O-methyltransferase activity
CWR56_RS05615	COG0826	peptidase U32
CWR56_RS05620	COG0768	penicillin binding
CWR56_RS05755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWR56_RS05765	COG0571	ribonuclease III activity
CWR56_RS05775	COG1196	nuclear chromosome segregation
CWR56_RS05780	COG0552	protein localization to endoplasmic reticulum
CWR56_RS05790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWR56_RS05795	COG0228	four-way junction DNA binding
CWR56_RS05805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWR56_RS05810	COG0336	Belongs to the RNA methyltransferase TrmD family
CWR56_RS05815	COG0335	large ribosomal subunit rRNA binding
CWR56_RS05825	COG1114	Component of the transport system for branched-chain amino acids
CWR56_RS05840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWR56_RS05870	COG1131	(ABC) transporter
CWR56_RS05875	COG2197	response regulator
CWR56_RS05880	COG4585	Histidine kinase
CWR56_RS05885	COG0792	nuclease activity
CWR56_RS05890	COG0606	chelatase, subunit chli
CWR56_RS05895	COG0758	DNA mediated transformation
CWR56_RS05900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWR56_RS05910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWR56_RS05920	COG1959	2 iron, 2 sulfur cluster binding
CWR56_RS05930	COG0822	iron-sulfur transferase activity
CWR56_RS05935	COG0482	sulfurtransferase activity
CWR56_RS05940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWR56_RS05945	COG4472	Bacterial protein of unknown function (DUF965)
CWR56_RS05955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWR56_RS05960	COG3906	Belongs to the UPF0473 family
CWR56_RS05965	COG0735	belongs to the Fur family
CWR56_RS05975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWR56_RS05985	COG1686	Belongs to the peptidase S11 family
CWR56_RS05995	COG2207	Transcriptional regulator
CWR56_RS05995	COG1917	Cupin 2, conserved barrel domain protein
CWR56_RS06000	COG1994	Peptidase M50
CWR56_RS06010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWR56_RS06065	COG0779	Required for maturation of 30S ribosomal subunits
CWR56_RS06070	COG0195	Participates in both transcription termination and antitermination
CWR56_RS06075	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CWR56_RS06085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWR56_RS06095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CWR56_RS06100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWR56_RS06105	COG0196	riboflavin kinase activity
CWR56_RS06115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWR56_RS06120	COG1307	EDD domain protein, DegV family
CWR56_RS06125	COG1185	polyribonucleotide nucleotidyltransferase activity
CWR56_RS06130	COG0726	polysaccharide deacetylase
CWR56_RS06135	COG0612	Peptidase, M16
CWR56_RS06140	COG1873	PFAM PRC-barrel domain
CWR56_RS06145	COG0527	aspartate kinase activity
CWR56_RS06150	COG0740	serine-type endopeptidase activity
CWR56_RS06160	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CWR56_RS06165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWR56_RS06175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CWR56_RS06180	COG1418	mRNA catabolic process
CWR56_RS06185	COG5001	Diguanylate cyclase
CWR56_RS06200	COG1968	undecaprenyl-diphosphatase activity
CWR56_RS06210	COG0114	fumarate hydratase activity
CWR56_RS06220	COG0436	Aminotransferase
CWR56_RS06230	COG0708	Exodeoxyribonuclease III
CWR56_RS06245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWR56_RS06270	COG1131	(ABC) transporter
CWR56_RS06300	COG1278	Cold shock
CWR56_RS06310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWR56_RS06390	COG3299	homolog of phage Mu protein gp47
CWR56_RS06395	COG3778	Protein conserved in bacteria
CWR56_RS06440	COG1396	sequence-specific DNA binding
CWR56_RS06445	COG2814	Major facilitator Superfamily
CWR56_RS06455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWR56_RS06460	COG0471	metal ion transport
CWR56_RS06460	COG3273	potassium ion transport
CWR56_RS06465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CWR56_RS06470	COG1914	H( )-stimulated, divalent metal cation uptake system
CWR56_RS06475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWR56_RS06480	COG1984	allophanate hydrolase subunit 2
CWR56_RS06485	COG1396	sequence-specific DNA binding
CWR56_RS06490	COG4948	Mandelate Racemase Muconate Lactonizing
CWR56_RS06535	COG1473	amidohydrolase
CWR56_RS06540	COG1619	proteins homologs of microcin C7 resistance protein MccF
CWR56_RS06555	COG0584	glycerophosphoryl diester phosphodiesterase
CWR56_RS06575	COG0488	(ABC) transporter
CWR56_RS06585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS06590	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWR56_RS06595	COG1546	Belongs to the CinA family
CWR56_RS06595	COG1058	Belongs to the CinA family
CWR56_RS06610	COG3829	transcription factor binding
CWR56_RS06620	COG1242	4 iron, 4 sulfur cluster binding
CWR56_RS06665	COG3447	MASE1 domain protein
CWR56_RS06665	COG5001	Diguanylate cyclase
CWR56_RS06665	COG5002	protein histidine kinase activity
CWR56_RS06670	COG2203	Gaf domain
CWR56_RS06670	COG2199	diguanylate cyclase activity
CWR56_RS06680	COG0789	Transcriptional regulator
CWR56_RS06680	COG4978	Transcriptional regulator
CWR56_RS06695	COG1285	pathogenesis
CWR56_RS06700	COG1335	isochorismatase
CWR56_RS06720	COG0726	polysaccharide deacetylase
CWR56_RS06735	COG0450	alkyl hydroperoxide reductase
CWR56_RS06750	COG2720	vancomycin resistance protein
CWR56_RS06755	COG3829	transcription factor binding
CWR56_RS06770	COG1346	cytolysis
CWR56_RS06775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR56_RS06785	COG2340	Cysteine-rich secretory protein family
CWR56_RS06790	COG0726	polysaccharide deacetylase
CWR56_RS06795	COG0512	Glutamine amidotransferase of anthranilate synthase
CWR56_RS06800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWR56_RS06805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWR56_RS06815	COG0302	gtp cyclohydrolase
CWR56_RS06820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWR56_RS06825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWR56_RS06830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWR56_RS06835	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CWR56_RS06840	COG0358	DNA primase activity
CWR56_RS06845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWR56_RS06850	COG2384	SAM-dependent methyltransferase
CWR56_RS06855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWR56_RS06860	COG0655	NAD(P)H dehydrogenase (quinone) activity
CWR56_RS06880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS06895	COG3850	Histidine kinase
CWR56_RS06895	COG5002	protein histidine kinase activity
CWR56_RS06900	COG1136	(ABC) transporter
CWR56_RS06900	COG0577	efflux transmembrane transporter activity
CWR56_RS06930	COG1132	(ABC) transporter
CWR56_RS06935	COG1132	(ABC) transporter
CWR56_RS06940	COG1592	Rubrerythrin
CWR56_RS06940	COG1773	rubredoxin
CWR56_RS06945	COG0412	Dienelactone hydrolase
CWR56_RS06980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR56_RS07015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWR56_RS07020	COG2011	ABC-type metal ion transport system permease component
CWR56_RS07030	COG5002	protein histidine kinase activity
CWR56_RS07035	COG2094	Belongs to the DNA glycosylase MPG family
CWR56_RS07040	COG1396	sequence-specific DNA binding
CWR56_RS07045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWR56_RS07050	COG4086	secreted protein
CWR56_RS07085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWR56_RS07095	COG1131	(ABC) transporter
CWR56_RS07105	COG0534	Mate efflux family protein
CWR56_RS07120	COG3901	Regulator of nitric oxide reductase transcription
CWR56_RS07120	COG0348	domain, Protein
CWR56_RS07150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWR56_RS07155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWR56_RS07165	COG5001	Diguanylate cyclase
CWR56_RS07175	COG0789	Transcriptional regulator
CWR56_RS07175	COG4978	Transcriptional regulator
CWR56_RS07180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWR56_RS07200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CWR56_RS07205	COG0726	polysaccharide deacetylase
CWR56_RS07215	COG1773	rubredoxin
CWR56_RS07215	COG1592	Rubrerythrin
CWR56_RS07220	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWR56_RS07225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CWR56_RS07230	COG0577	efflux transmembrane transporter activity
CWR56_RS07235	COG1136	(ABC) transporter
CWR56_RS07235	COG0577	efflux transmembrane transporter activity
CWR56_RS07245	COG2205	protein histidine kinase activity
CWR56_RS07250	COG0745	RESPONSE REGULATOR receiver
CWR56_RS07255	COG1136	(ABC) transporter
CWR56_RS07260	COG0577	efflux transmembrane transporter activity
CWR56_RS07265	COG0405	Gamma-glutamyltransferase
CWR56_RS07280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWR56_RS07280	COG0493	'glutamate synthase
CWR56_RS07290	COG1136	(ABC) transporter
CWR56_RS07295	COG0577	efflux transmembrane transporter activity
CWR56_RS07335	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CWR56_RS07340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWR56_RS07345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWR56_RS07350	COG0131	Imidazoleglycerol-phosphate dehydratase
CWR56_RS07355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWR56_RS07360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWR56_RS07365	COG0107	imidazoleglycerol-phosphate synthase activity
CWR56_RS07370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CWR56_RS07370	COG0140	phosphoribosyl-ATP diphosphatase activity
CWR56_RS07375	COG0531	amino acid
CWR56_RS07390	COG1595	DNA-templated transcription, initiation
CWR56_RS07405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CWR56_RS07420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWR56_RS07425	COG0028	Belongs to the TPP enzyme family
CWR56_RS07430	COG3546	catalase activity
CWR56_RS07435	COG1331	Highly conserved protein containing a thioredoxin domain
CWR56_RS07445	COG2267	carboxylic ester hydrolase activity
CWR56_RS07460	COG1388	LysM domain
CWR56_RS07460	COG3584	3D domain protein
CWR56_RS07470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWR56_RS07475	COG1295	ribonuclease BN
CWR56_RS07480	COG5002	protein histidine kinase activity
CWR56_RS07485	COG0460	homoserine dehydrogenase
CWR56_RS07495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWR56_RS07500	COG2267	carboxylic ester hydrolase activity
CWR56_RS07505	COG5566	PFAM Mor transcription activator
CWR56_RS07515	COG2971	BadF BadG BcrA BcrD
CWR56_RS07525	COG1129	ABC transporter
CWR56_RS07530	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWR56_RS07540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR56_RS07550	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CWR56_RS07555	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CWR56_RS07560	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CWR56_RS07565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWR56_RS07570	COG1045	serine acetyltransferase
CWR56_RS07575	COG1141	Ferredoxin
CWR56_RS07595	COG0351	phosphomethylpyrimidine kinase
CWR56_RS07600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CWR56_RS07605	COG0352	thiamine-phosphate diphosphorylase activity
CWR56_RS07610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS07630	COG1725	Transcriptional regulator
CWR56_RS07660	COG0402	S-adenosylhomocysteine deaminase activity
CWR56_RS07670	COG4555	ABC transporter
CWR56_RS07675	COG1668	transmembrane transport
CWR56_RS07680	COG3300	MHYT domain
CWR56_RS07680	COG5001	Diguanylate cyclase
CWR56_RS07685	COG1725	Transcriptional regulator
CWR56_RS07690	COG1131	(ABC) transporter
CWR56_RS07705	COG0668	transmembrane transport
CWR56_RS07715	COG0426	domain, Protein
CWR56_RS07730	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWR56_RS07735	COG1876	peptidase activity
CWR56_RS07760	COG0367	asparagine synthase
CWR56_RS07765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWR56_RS07790	COG2310	stress, protein
CWR56_RS07805	COG3853	Toxic anion resistance protein (TelA)
CWR56_RS07835	COG5505	Protein of unknown function (DUF819)
CWR56_RS07845	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR56_RS07850	COG4605	iron ion homeostasis
CWR56_RS07855	COG4604	ABC transporter, ATP-binding protein
CWR56_RS07865	COG4251	negative regulation of phosphorylation
CWR56_RS07865	COG5001	Diguanylate cyclase
CWR56_RS07865	COG3706	GGDEF domain
CWR56_RS07865	COG2203	Gaf domain
CWR56_RS07880	COG0095	Lipoate-protein ligase
CWR56_RS07885	COG1757	Na H antiporter
CWR56_RS07900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWR56_RS07905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWR56_RS07910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWR56_RS07915	COG3123	guanosine phosphorylase activity
CWR56_RS07920	COG0402	S-adenosylhomocysteine deaminase activity
CWR56_RS07935	COG1396	sequence-specific DNA binding
CWR56_RS07945	COG0584	glycerophosphoryl diester phosphodiesterase
CWR56_RS07965	COG1131	(ABC) transporter
CWR56_RS07975	COG0745	RESPONSE REGULATOR receiver
CWR56_RS07980	COG2205	protein histidine kinase activity
CWR56_RS08000	COG1733	regulation of RNA biosynthetic process
CWR56_RS08005	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CWR56_RS08035	COG1309	transcriptional regulator
CWR56_RS08070	COG0745	RESPONSE REGULATOR receiver
CWR56_RS08075	COG5002	protein histidine kinase activity
CWR56_RS08080	COG3118	belongs to the thioredoxin family
CWR56_RS08110	COG1115	amino acid carrier protein
CWR56_RS08120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWR56_RS08120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWR56_RS08135	COG0514	ATP-dependent DNA helicase (RecQ)
CWR56_RS08140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CWR56_RS08155	COG2022	thiamine diphosphate biosynthetic process
CWR56_RS08160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWR56_RS08170	COG1288	antiporter activity
CWR56_RS08190	COG0393	Putative heavy-metal-binding
CWR56_RS08195	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWR56_RS08205	COG0315	cyclic pyranopterin monophosphate synthase activity
CWR56_RS08280	COG1283	sodium-dependent phosphate transmembrane transporter activity
CWR56_RS08305	COG5012	cobalamin binding
CWR56_RS08310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWR56_RS08320	COG1011	Hydrolase
CWR56_RS08325	COG1917	Cupin 2, conserved barrel domain protein
CWR56_RS08325	COG1396	sequence-specific DNA binding
CWR56_RS08330	COG2610	gluconate transmembrane transporter activity
CWR56_RS08335	COG5002	protein histidine kinase activity
CWR56_RS08340	COG2204	response regulator
CWR56_RS08380	COG0786	glutamate:sodium symporter activity
CWR56_RS08395	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CWR56_RS08400	COG1924	4 iron, 4 sulfur cluster binding
CWR56_RS08405	COG2247	cell wall binding repeat
CWR56_RS08405	COG2385	sporulation resulting in formation of a cellular spore
CWR56_RS08415	COG1309	transcriptional regulator
CWR56_RS08440	COG0242	peptide deformylase activity
CWR56_RS08475	COG3326	Membrane
CWR56_RS08490	COG0494	nUDIX hydrolase
CWR56_RS08540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR56_RS08545	COG0765	amino acid transport
CWR56_RS08555	COG1393	Belongs to the ArsC family
CWR56_RS08565	COG1606	tRNA processing
CWR56_RS08570	COG0116	Belongs to the methyltransferase superfamily
CWR56_RS08585	COG5002	protein histidine kinase activity
CWR56_RS08585	COG3850	Histidine kinase
CWR56_RS08595	COG0137	argininosuccinate synthase activity
CWR56_RS08605	COG0789	Transcriptional regulator
CWR56_RS08615	COG2323	membrane
CWR56_RS08630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWR56_RS08655	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWR56_RS08660	COG0583	DNA-binding transcription factor activity
CWR56_RS08675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR56_RS08690	COG1609	Transcriptional regulator
CWR56_RS08700	COG1621	beta-fructofuranosidase activity
CWR56_RS08705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWR56_RS08720	COG2814	Major facilitator Superfamily
CWR56_RS08750	COG0406	alpha-ribazole phosphatase activity
CWR56_RS08755	COG2081	HI0933 family
CWR56_RS08760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CWR56_RS08765	COG0204	Acyl-transferase
CWR56_RS08770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWR56_RS08785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CWR56_RS08790	COG3022	response to hydroperoxide
CWR56_RS08805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CWR56_RS08810	COG1846	Transcriptional regulator
CWR56_RS08815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWR56_RS08820	COG2205	protein histidine kinase activity
CWR56_RS08830	COG0598	Magnesium transport protein CorA
CWR56_RS08840	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CWR56_RS08845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWR56_RS08850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWR56_RS08855	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWR56_RS08860	COG1605	Chorismate mutase
CWR56_RS08860	COG0077	Prephenate dehydratase
CWR56_RS08865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWR56_RS08875	COG0287	Prephenate dehydrogenase
CWR56_RS08885	COG3706	GGDEF domain
CWR56_RS08920	COG2207	Transcriptional regulator
CWR56_RS08920	COG3708	Transcriptional regulator
CWR56_RS08960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWR56_RS08965	COG2226	methyltransferase
CWR56_RS08970	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CWR56_RS09000	COG2131	deaminase
CWR56_RS09030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR56_RS09080	COG4303	Ethanolamine ammonia lyase large subunit
CWR56_RS09085	COG4302	ethanolamine ammonia-lyase activity
CWR56_RS09100	COG1012	belongs to the aldehyde dehydrogenase family
CWR56_RS09100	COG1454	alcohol dehydrogenase
CWR56_RS09115	COG4869	propanediol catabolic process
CWR56_RS09125	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CWR56_RS09135	COG3192	ethanolamine utilization protein
CWR56_RS09140	COG4766	ethanolamine catabolic process
CWR56_RS09150	COG1473	amidohydrolase
CWR56_RS09155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CWR56_RS09160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWR56_RS09165	COG1116	anion transmembrane transporter activity
CWR56_RS09185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWR56_RS09190	COG4974	Belongs to the 'phage' integrase family
CWR56_RS09205	COG2359	stage V sporulation protein S
CWR56_RS09210	COG0825	malonyl-CoA metabolic process
CWR56_RS09215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CWR56_RS09220	COG0439	Biotin carboxylase
CWR56_RS09225	COG0511	ligase activity, forming carbon-carbon bonds
CWR56_RS09245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWR56_RS09270	COG1136	(ABC) transporter
CWR56_RS09280	COG2205	protein histidine kinase activity
CWR56_RS09285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR56_RS09290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWR56_RS09310	COG1136	(ABC) transporter
CWR56_RS09315	COG2205	protein histidine kinase activity
CWR56_RS09320	COG0745	RESPONSE REGULATOR receiver
CWR56_RS09330	COG0745	RESPONSE REGULATOR receiver
CWR56_RS09335	COG5002	protein histidine kinase activity
CWR56_RS09340	COG1136	(ABC) transporter
CWR56_RS09340	COG0577	efflux transmembrane transporter activity
CWR56_RS09375	COG1811	Na channel or pump
CWR56_RS09380	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CWR56_RS09395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR56_RS09400	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CWR56_RS09405	COG1923	regulation of RNA biosynthetic process
CWR56_RS09410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWR56_RS09415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWR56_RS09420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CWR56_RS09425	COG1116	anion transmembrane transporter activity
CWR56_RS09430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWR56_RS09435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR56_RS09450	COG1733	regulation of RNA biosynthetic process
CWR56_RS09460	COG0494	nUDIX hydrolase
CWR56_RS09470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWR56_RS09475	COG2247	cell wall binding repeat
CWR56_RS09475	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS09530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWR56_RS09550	COG0730	response to heat
CWR56_RS09555	COG2207	Transcriptional regulator
CWR56_RS09570	COG0596	Alpha beta hydrolase
CWR56_RS09575	COG1309	transcriptional regulator
CWR56_RS09590	COG1404	Belongs to the peptidase S8 family
CWR56_RS09610	COG0129	dihydroxy-acid dehydratase activity
CWR56_RS09640	COG2207	Transcriptional regulator
CWR56_RS09645	COG2814	Major facilitator Superfamily
CWR56_RS09665	COG1725	Transcriptional regulator
CWR56_RS09690	COG1794	racemase activity, acting on amino acids and derivatives
CWR56_RS09700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWR56_RS09705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWR56_RS09710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWR56_RS09715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CWR56_RS09770	COG1309	transcriptional regulator
CWR56_RS09795	COG3655	Transcriptional regulator
CWR56_RS09810	COG1737	Transcriptional regulator
CWR56_RS09815	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CWR56_RS09820	COG1187	pseudouridine synthase activity
CWR56_RS09825	COG0628	permease
CWR56_RS09835	COG0019	diaminopimelate decarboxylase activity
CWR56_RS09840	COG0527	aspartate kinase activity
CWR56_RS09870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWR56_RS09875	COG1597	lipid kinase activity
CWR56_RS09905	COG0582	viral genome integration into host DNA
CWR56_RS09915	COG0488	(ABC) transporter
CWR56_RS09930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWR56_RS09940	COG2080	2 iron, 2 sulfur cluster binding
CWR56_RS09940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWR56_RS09950	COG2233	PERMEase
CWR56_RS09965	COG0167	dihydroorotate dehydrogenase activity
CWR56_RS09970	COG0402	S-adenosylhomocysteine deaminase activity
CWR56_RS09990	COG0402	S-adenosylhomocysteine deaminase activity
CWR56_RS10015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWR56_RS10040	COG3829	transcription factor binding
CWR56_RS10050	COG1401	restriction endodeoxyribonuclease activity
CWR56_RS10065	COG4708	membrane
CWR56_RS10075	COG2080	2 iron, 2 sulfur cluster binding
CWR56_RS10075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWR56_RS10110	COG1131	(ABC) transporter
CWR56_RS10120	COG2252	PERMEase
CWR56_RS10125	COG0534	Mate efflux family protein
CWR56_RS10135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWR56_RS10140	COG1349	DNA-binding transcription factor activity
CWR56_RS10150	COG5002	protein histidine kinase activity
CWR56_RS10155	COG0745	RESPONSE REGULATOR receiver
CWR56_RS10160	COG2217	Heavy metal translocating P-type atpase
CWR56_RS10175	COG1217	gtp-binding protein TYPA
CWR56_RS10180	COG0492	ferredoxin-NADP+ reductase activity
CWR56_RS10220	COG1247	-acetyltransferase
CWR56_RS10245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWR56_RS10250	COG0750	zinc metalloprotease
CWR56_RS10255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWR56_RS10280	COG4589	Belongs to the CDS family
CWR56_RS10295	COG0233	cytoplasmic translational termination
CWR56_RS10300	COG0528	UMP kinase activity
CWR56_RS10305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWR56_RS10310	COG0052	Belongs to the universal ribosomal protein uS2 family
CWR56_RS10315	COG1686	Belongs to the peptidase S11 family
CWR56_RS10330	COG1971	Probably functions as a manganese efflux pump
CWR56_RS10335	COG1193	negative regulation of DNA recombination
CWR56_RS10350	COG2720	vancomycin resistance protein
CWR56_RS10370	COG1363	Peptidase, m42
CWR56_RS10380	COG1160	GTP binding
CWR56_RS10385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWR56_RS10435	COG0039	L-malate dehydrogenase activity
CWR56_RS10445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWR56_RS10445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWR56_RS10455	COG1151	hydroxylamine reductase activity
CWR56_RS10475	COG1301	dicarboxylic acid transport
CWR56_RS10480	COG1126	abc transporter atp-binding protein
CWR56_RS10505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR56_RS10510	COG0437	4 iron, 4 sulfur cluster binding
CWR56_RS10520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWR56_RS10525	COG0596	Alpha beta hydrolase
CWR56_RS10535	COG0513	Belongs to the DEAD box helicase family
CWR56_RS10555	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWR56_RS10560	COG1554	hydrolase, family 65, central catalytic
CWR56_RS10565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR56_RS10575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWR56_RS10585	COG2385	sporulation resulting in formation of a cellular spore
CWR56_RS10585	COG2247	cell wall binding repeat
CWR56_RS10595	COG1528	Iron-storage protein
CWR56_RS10615	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWR56_RS10615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CWR56_RS10625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWR56_RS10640	COG1309	transcriptional regulator
CWR56_RS10650	COG0628	permease
CWR56_RS10655	COG1012	belongs to the aldehyde dehydrogenase family
CWR56_RS10670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWR56_RS10695	COG0288	reversible hydration of carbon dioxide
CWR56_RS10715	COG0710	3-dehydroquinate dehydratase activity
CWR56_RS10775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWR56_RS10835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWR56_RS10840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR56_RS10845	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CWR56_RS10860	COG5001	Diguanylate cyclase
CWR56_RS10860	COG4251	negative regulation of phosphorylation
CWR56_RS10860	COG3706	GGDEF domain
CWR56_RS10860	COG2203	Gaf domain
CWR56_RS10865	COG0017	Asparaginyl-tRNA synthetase
CWR56_RS10875	COG1404	Belongs to the peptidase S8 family
CWR56_RS10880	COG1404	Belongs to the peptidase S8 family
CWR56_RS10890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWR56_RS10985	COG3708	Transcriptional regulator
CWR56_RS10985	COG2207	Transcriptional regulator
CWR56_RS10995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWR56_RS11000	COG1720	tRNA m6t6A37 methyltransferase activity
CWR56_RS11030	COG2814	Major facilitator Superfamily
CWR56_RS11035	COG0574	Belongs to the PEP-utilizing enzyme family
CWR56_RS11035	COG3848	Pyruvate phosphate dikinase
CWR56_RS11040	COG1309	transcriptional regulator
CWR56_RS11050	COG0791	NLP P60 protein
CWR56_RS11050	COG0741	lytic transglycosylase activity
CWR56_RS11105	COG2946	Replication initiation factor
CWR56_RS11110	COG1674	ftsk spoiiie
CWR56_RS11170	COG1509	lysine 2,3-aminomutase activity
CWR56_RS11175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS11180	COG1794	racemase activity, acting on amino acids and derivatives
CWR56_RS11200	COG0662	Cupin 2, conserved barrel domain protein
CWR56_RS11205	COG3104	oligopeptide transport
CWR56_RS11210	COG0006	proline dipeptidase activity
CWR56_RS11215	COG3104	oligopeptide transport
CWR56_RS11220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWR56_RS11235	COG0723	plastoquinol--plastocyanin reductase activity
CWR56_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR56_RS11240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS11240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS11240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS11245	COG1105	Belongs to the carbohydrate kinase PfkB family
CWR56_RS11250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS11250	COG3711	transcriptional antiterminator
CWR56_RS11255	COG2365	Tyrosine phosphatase family
CWR56_RS11275	COG1115	amino acid carrier protein
CWR56_RS11280	COG0235	Class ii aldolase
CWR56_RS11285	COG0235	Class ii aldolase
CWR56_RS11290	COG1063	alcohol dehydrogenase
CWR56_RS11295	COG3775	system Galactitol-specific IIC component
CWR56_RS11300	COG3414	Phosphotransferase system galactitol-specific IIB component
CWR56_RS11305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS11305	COG2213	PTS system mannitol-specific
CWR56_RS11310	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CWR56_RS11310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWR56_RS11330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS11335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWR56_RS11345	COG5002	protein histidine kinase activity
CWR56_RS11405	COG3617	BRO family, N-terminal domain
CWR56_RS11470	COG3620	sequence-specific DNA binding
CWR56_RS11495	COG3842	ATPase activity
CWR56_RS11515	COG2205	protein histidine kinase activity
CWR56_RS11520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWR56_RS11525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWR56_RS11530	COG0698	ribose 5-phosphate isomerase
CWR56_RS11535	COG3958	Transketolase
CWR56_RS11540	COG3959	Transketolase, thiamine diphosphate binding domain
CWR56_RS11555	COG3775	system Galactitol-specific IIC component
CWR56_RS11560	COG3414	Phosphotransferase system galactitol-specific IIB component
CWR56_RS11570	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CWR56_RS11570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWR56_RS11575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWR56_RS11580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWR56_RS11585	COG0246	Mannitol dehydrogenase
CWR56_RS11590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS11595	COG3711	transcriptional antiterminator
CWR56_RS11605	COG0517	IMP dehydrogenase activity
CWR56_RS11605	COG0516	GMP reductase activity
CWR56_RS11610	COG3853	Toxic anion resistance protein (TelA)
CWR56_RS11620	COG1454	alcohol dehydrogenase
CWR56_RS11625	COG0427	acetyl-CoA hydrolase
CWR56_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
CWR56_RS11645	COG0427	acetyl-CoA hydrolase
CWR56_RS11650	COG2985	domain, Protein
CWR56_RS11650	COG0490	domain, Protein
CWR56_RS11650	COG0490	domain, Protein
CWR56_RS11650	COG2985	domain, Protein
CWR56_RS11655	COG0583	DNA-binding transcription factor activity
CWR56_RS11665	COG0006	proline dipeptidase activity
CWR56_RS11695	COG3118	belongs to the thioredoxin family
CWR56_RS11715	COG0561	phosphatase activity
CWR56_RS11730	COG1116	anion transmembrane transporter activity
CWR56_RS11740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR56_RS11780	COG0157	Belongs to the NadC ModD family
CWR56_RS11790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CWR56_RS11795	COG1966	Carbon starvation protein
CWR56_RS11810	COG0628	permease
CWR56_RS11820	COG2364	Membrane
CWR56_RS11910	COG0791	NLP P60 protein
CWR56_RS11910	COG0741	lytic transglycosylase activity
CWR56_RS11960	COG2946	Replication initiation factor
CWR56_RS11970	COG1674	ftsk spoiiie
CWR56_RS11975	COG3620	sequence-specific DNA binding
CWR56_RS12000	COG3426	butyrate kinase activity
CWR56_RS12025	COG2199	diguanylate cyclase activity
CWR56_RS12030	COG2203	Gaf domain
CWR56_RS12030	COG2199	diguanylate cyclase activity
CWR56_RS12075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR56_RS12075	COG0072	phenylalanine-tRNA ligase activity
CWR56_RS12080	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CWR56_RS12085	COG2176	DNA-directed DNA polymerase activity
CWR56_RS12105	COG0037	tRNA processing
CWR56_RS12120	COG3546	catalase activity
CWR56_RS12125	COG1388	LysM domain
CWR56_RS12125	COG3103	Sh3 type 3 domain protein
CWR56_RS12125	COG0791	NLP P60 protein
CWR56_RS12135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWR56_RS12135	COG0551	DNA topoisomerase type I activity
CWR56_RS12165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWR56_RS12165	COG0574	Belongs to the PEP-utilizing enzyme family
CWR56_RS12170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CWR56_RS12175	COG0517	IMP dehydrogenase activity
CWR56_RS12195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS12195	COG3711	transcriptional antiterminator
CWR56_RS12200	COG3732	PTS system glucitol sorbitol-specific
CWR56_RS12210	COG2207	Transcriptional regulator
CWR56_RS12225	COG1115	amino acid carrier protein
CWR56_RS12230	COG2223	nitrite transmembrane transporter activity
CWR56_RS12235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS12240	COG0280	phosphate acetyltransferase
CWR56_RS12260	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWR56_RS12260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CWR56_RS12270	COG1414	Transcriptional regulator
CWR56_RS12280	COG0751	glycine-tRNA ligase activity
CWR56_RS12285	COG0752	glycyl-tRNA synthetase alpha subunit
CWR56_RS12295	COG1381	Involved in DNA repair and RecF pathway recombination
CWR56_RS12305	COG2239	Acts as a magnesium transporter
CWR56_RS12310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWR56_RS12315	COG0295	cytidine deaminase activity
CWR56_RS12320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CWR56_RS12325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWR56_RS12330	COG1702	phosphate starvation-inducible protein PhoH
CWR56_RS12350	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CWR56_RS12355	COG1610	YqeY-like protein
CWR56_RS12360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CWR56_RS12365	COG0537	adenosine 5'-monophosphoramidase activity
CWR56_RS12370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWR56_RS12375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWR56_RS12380	COG2264	protein methyltransferase activity
CWR56_RS12410	COG3842	ATPase activity
CWR56_RS12415	COG2508	Transcriptional regulator
CWR56_RS12420	COG0477	Major facilitator Superfamily
CWR56_RS12435	COG0484	heat shock protein binding
CWR56_RS12440	COG0443	Heat shock 70 kDa protein
CWR56_RS12445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWR56_RS12450	COG1420	regulation of RNA biosynthetic process
CWR56_RS12455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWR56_RS12460	COG0531	amino acid
CWR56_RS12465	COG0617	tRNA 3'-terminal CCA addition
CWR56_RS12470	COG0481	GTPase activity
CWR56_RS12500	COG0268	Binds directly to 16S ribosomal RNA
CWR56_RS12510	COG2333	competence protein COMEC
CWR56_RS12510	COG0658	competence protein
CWR56_RS12530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CWR56_RS12535	COG1388	LysM domain
CWR56_RS12535	COG3584	3D domain protein
CWR56_RS12540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWR56_RS12555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWR56_RS12560	COG0006	proline dipeptidase activity
CWR56_RS12565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS12570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS12580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS12580	COG3711	transcriptional antiterminator
CWR56_RS12585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR56_RS12590	COG1482	cell wall glycoprotein biosynthetic process
CWR56_RS12595	COG5002	protein histidine kinase activity
CWR56_RS12615	COG1555	photosystem II stabilization
CWR56_RS12620	COG1686	Belongs to the peptidase S11 family
CWR56_RS12630	COG0165	Argininosuccinate lyase
CWR56_RS12635	COG0561	phosphatase activity
CWR56_RS12640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWR56_RS12645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWR56_RS12650	COG1876	peptidase activity
CWR56_RS12655	COG1309	transcriptional regulator
CWR56_RS12660	COG2814	Major facilitator Superfamily
CWR56_RS12670	COG4977	sequence-specific DNA binding
CWR56_RS12680	COG1263	PTS System
CWR56_RS12680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS12685	COG3711	transcriptional antiterminator
CWR56_RS12690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS12690	COG1263	PTS System
CWR56_RS12690	COG2190	(PTS) system
CWR56_RS12695	COG0251	oxidation-reduction process
CWR56_RS12700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWR56_RS12745	COG0495	leucyl-tRNA aminoacylation
CWR56_RS12750	COG0799	negative regulation of ribosome biogenesis
CWR56_RS12755	COG1713	HD superfamily hydrolase involved in NAD metabolism
CWR56_RS12760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWR56_RS12765	COG2137	regulation of response to DNA damage stimulus
CWR56_RS12770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CWR56_RS12775	COG1309	transcriptional regulator
CWR56_RS12800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CWR56_RS12810	COG0577	efflux transmembrane transporter activity
CWR56_RS12810	COG1136	(ABC) transporter
CWR56_RS12820	COG0745	RESPONSE REGULATOR receiver
CWR56_RS12825	COG0737	Belongs to the 5'-nucleotidase family
CWR56_RS12835	COG1234	tRNA 3'-trailer cleavage
CWR56_RS12840	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWR56_RS12845	COG1823	symporter activity
CWR56_RS12870	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CWR56_RS12870	COG4124	Belongs to the glycosyl hydrolase 26 family
CWR56_RS12880	COG0395	ABC-type sugar transport system, permease component
CWR56_RS12900	COG4821	SIS domain
CWR56_RS12930	COG0742	ribosomal rna small subunit methyltransferase
CWR56_RS12935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CWR56_RS12940	COG1461	Dihydroxyacetone kinase
CWR56_RS12945	COG1302	Protein conserved in bacteria
CWR56_RS12950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWR56_RS12965	COG0789	Transcriptional regulator
CWR56_RS12970	COG3711	transcriptional antiterminator
CWR56_RS12970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS12975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS12975	COG3711	transcriptional antiterminator
CWR56_RS12980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS12985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS12990	COG0383	alpha-mannosidase activity
CWR56_RS13015	COG1564	THIamine pyrophosphokinase
CWR56_RS13020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWR56_RS13025	COG1162	GTPase activity
CWR56_RS13030	COG1028	Short-chain dehydrogenase reductase Sdr
CWR56_RS13035	COG0515	serine threonine protein kinase
CWR56_RS13035	COG2815	serine threonine protein kinase
CWR56_RS13045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWR56_RS13050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWR56_RS13050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWR56_RS13055	COG2738	Putative neutral zinc metallopeptidase
CWR56_RS13065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWR56_RS13070	COG0242	peptide deformylase activity
CWR56_RS13075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWR56_RS13080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWR56_RS13085	COG1758	RNA polymerase activity
CWR56_RS13090	COG0194	GDP metabolic process
CWR56_RS13095	COG1561	YicC-like family, N-terminal region
CWR56_RS13100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWR56_RS13110	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CWR56_RS13115	COG0488	(ABC) transporter
CWR56_RS13125	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CWR56_RS13130	COG0564	pseudouridine synthase activity
CWR56_RS13135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWR56_RS13145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CWR56_RS13150	COG1966	Carbon starvation protein
CWR56_RS13155	COG3279	Response regulator of the LytR AlgR family
CWR56_RS13160	COG3275	phosphorelay sensor kinase activity
CWR56_RS13195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWR56_RS13200	COG0531	amino acid
CWR56_RS13205	COG0006	proline dipeptidase activity
CWR56_RS13210	COG1307	EDD domain protein, DegV family
CWR56_RS13225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR56_RS13230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CWR56_RS13240	COG2302	S4 RNA-binding domain
CWR56_RS13250	COG1799	cell septum assembly
CWR56_RS13255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWR56_RS13275	COG3830	Belongs to the UPF0237 family
CWR56_RS13285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CWR56_RS13295	COG0531	amino acid
CWR56_RS13300	COG0006	proline dipeptidase activity
CWR56_RS13310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWR56_RS13315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CWR56_RS13320	COG1160	GTP binding
CWR56_RS13345	COG5002	protein histidine kinase activity
CWR56_RS13350	COG0745	RESPONSE REGULATOR receiver
CWR56_RS13360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWR56_RS13365	COG1873	PFAM PRC-barrel domain
CWR56_RS13370	COG1191	sigma factor activity
CWR56_RS13375	COG1191	sigma factor activity
CWR56_RS13390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWR56_RS13395	COG3856	small basic protein
CWR56_RS13415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWR56_RS13420	COG0772	Belongs to the SEDS family
CWR56_RS13425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWR56_RS13430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWR56_RS13435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWR56_RS13440	COG0768	penicillin binding
CWR56_RS13450	COG0275	rRNA processing
CWR56_RS13455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWR56_RS13460	COG0612	Peptidase, M16
CWR56_RS13470	COG0012	GTP binding
CWR56_RS13480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWR56_RS13490	COG1263	PTS System
CWR56_RS13490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS13490	COG2190	(PTS) system
CWR56_RS13495	COG3711	transcriptional antiterminator
CWR56_RS13500	COG0025	NhaP-type Na H and K H
CWR56_RS13505	COG4608	Belongs to the ABC transporter superfamily
CWR56_RS13510	COG0444	Belongs to the ABC transporter superfamily
CWR56_RS13520	COG0601	transmembrane transport
CWR56_RS13525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR56_RS13530	COG0583	DNA-binding transcription factor activity
CWR56_RS13535	COG0183	Belongs to the thiolase family
CWR56_RS13540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CWR56_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
CWR56_RS13555	COG2610	gluconate transmembrane transporter activity
CWR56_RS13560	COG2340	Cysteine-rich secretory protein family
CWR56_RS13575	COG4869	propanediol catabolic process
CWR56_RS13610	COG2081	HI0933 family
CWR56_RS13615	COG0671	phosphoesterase, PA-phosphatase related
CWR56_RS13625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWR56_RS13640	COG2502	aspartate--ammonia ligase
CWR56_RS13645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWR56_RS13650	COG1473	amidohydrolase
CWR56_RS13660	COG3366	ferrous iron transmembrane transporter activity
CWR56_RS13685	COG2252	PERMEase
CWR56_RS13690	COG0402	S-adenosylhomocysteine deaminase activity
CWR56_RS13700	COG2271	Major facilitator Superfamily
CWR56_RS13720	COG0583	DNA-binding transcription factor activity
CWR56_RS13730	COG1376	ErfK ybiS ycfS ynhG family protein
CWR56_RS13735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWR56_RS13740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWR56_RS13765	COG4509	Sortase family
CWR56_RS13785	COG0726	polysaccharide deacetylase
CWR56_RS13790	COG3069	C4-dicarboxylate transmembrane transporter activity
CWR56_RS13795	COG0642	Histidine kinase
CWR56_RS13795	COG5002	protein histidine kinase activity
CWR56_RS13800	COG0745	RESPONSE REGULATOR receiver
CWR56_RS13815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWR56_RS13820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWR56_RS13840	COG1937	Protein conserved in bacteria
CWR56_RS13855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWR56_RS13860	COG1757	Na H antiporter
CWR56_RS13870	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS13870	COG2247	cell wall binding repeat
CWR56_RS13875	COG0583	DNA-binding transcription factor activity
CWR56_RS13880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWR56_RS13890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWR56_RS13895	COG0124	histidyl-tRNA synthetase
CWR56_RS13900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWR56_RS13905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWR56_RS13910	COG1490	D-aminoacyl-tRNA deacylase activity
CWR56_RS13915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWR56_RS13920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWR56_RS13925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWR56_RS13925	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CWR56_RS13965	COG5001	Diguanylate cyclase
CWR56_RS13970	COG3706	GGDEF domain
CWR56_RS13980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS14005	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS14010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWR56_RS14020	COG0561	phosphatase activity
CWR56_RS14025	COG1316	TRANSCRIPTIONal
CWR56_RS14030	COG1316	TRANSCRIPTIONal
CWR56_RS14035	COG1649	PFAM Uncharacterised BCR, COG1649
CWR56_RS14050	COG0438	transferase activity, transferring glycosyl groups
CWR56_RS14055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CWR56_RS14060	COG1215	transferase activity, transferring glycosyl groups
CWR56_RS14070	COG1215	transferase activity, transferring glycosyl groups
CWR56_RS14075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWR56_RS14075	COG1215	transferase activity, transferring glycosyl groups
CWR56_RS14080	COG1216	Glycosyl transferase, family 2
CWR56_RS14100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWR56_RS14105	COG0728	peptidoglycan biosynthetic process
CWR56_RS14110	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS14110	COG2247	cell wall binding repeat
CWR56_RS14115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWR56_RS14120	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS14135	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS14135	COG2247	cell wall binding repeat
CWR56_RS14145	COG2246	polysaccharide biosynthetic process
CWR56_RS14150	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS14150	COG2247	cell wall binding repeat
CWR56_RS14165	COG0653	protein targeting
CWR56_RS14200	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS14200	COG2247	cell wall binding repeat
CWR56_RS14220	COG0343	queuine tRNA-ribosyltransferase activity
CWR56_RS14230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CWR56_RS14235	COG2255	four-way junction helicase activity
CWR56_RS14240	COG0632	four-way junction helicase activity
CWR56_RS14245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CWR56_RS14270	COG2610	gluconate transmembrane transporter activity
CWR56_RS14275	COG2084	Dehydrogenase
CWR56_RS14295	COG1132	(ABC) transporter
CWR56_RS14315	COG0700	Nucleoside recognition
CWR56_RS14320	COG3366	ferrous iron transmembrane transporter activity
CWR56_RS14325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR56_RS14355	COG0436	Aminotransferase
CWR56_RS14360	COG0697	spore germination
CWR56_RS14375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWR56_RS14390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWR56_RS14395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CWR56_RS14400	COG1473	amidohydrolase
CWR56_RS14405	COG3949	Membrane
CWR56_RS14420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWR56_RS14435	COG0604	alcohol dehydrogenase
CWR56_RS14445	COG1592	Rubrerythrin
CWR56_RS14480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR56_RS14480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CWR56_RS14485	COG1349	DNA-binding transcription factor activity
CWR56_RS14490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWR56_RS14495	COG1696	Membrane protein involved in D-alanine export
CWR56_RS14500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWR56_RS14510	COG0673	inositol 2-dehydrogenase activity
CWR56_RS14520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR56_RS14525	COG1253	flavin adenine dinucleotide binding
CWR56_RS14530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CWR56_RS14550	COG3829	transcription factor binding
CWR56_RS14550	COG3290	protein histidine kinase activity
CWR56_RS14555	COG2267	carboxylic ester hydrolase activity
CWR56_RS14565	COG0312	modulator of DNA gyrase
CWR56_RS14570	COG0312	modulator of DNA gyrase
CWR56_RS14595	COG2721	sulfolactate sulfo-lyase activity
CWR56_RS14610	COG1120	ATPase activity
CWR56_RS14615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR56_RS14620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR56_RS14635	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWR56_RS14640	COG3394	polysaccharide catabolic process
CWR56_RS14645	COG1486	melibiose metabolic process
CWR56_RS14650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS14660	COG2188	Transcriptional regulator
CWR56_RS14665	COG0534	Mate efflux family protein
CWR56_RS14670	COG2199	diguanylate cyclase activity
CWR56_RS14675	COG1178	ABC-type Fe3 transport system permease component
CWR56_RS14680	COG3842	ATPase activity
CWR56_RS14685	COG1840	ABC-type Fe3 transport system, periplasmic component
CWR56_RS14690	COG1394	ATPase activity, coupled to movement of substances
CWR56_RS14695	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CWR56_RS14700	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CWR56_RS14715	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CWR56_RS14720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWR56_RS14725	COG1269	ATP hydrolysis coupled proton transport
CWR56_RS14750	COG3300	MHYT domain
CWR56_RS14750	COG5001	Diguanylate cyclase
CWR56_RS14755	COG1012	belongs to the aldehyde dehydrogenase family
CWR56_RS14755	COG1454	alcohol dehydrogenase
CWR56_RS14765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWR56_RS14775	COG0318	PFAM AMP-dependent synthetase and ligase
CWR56_RS14780	COG0183	Belongs to the thiolase family
CWR56_RS14785	COG1268	BioY protein
CWR56_RS14800	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CWR56_RS14815	COG1203	CRISPR-associated helicase, Cas3
CWR56_RS14845	COG0577	efflux transmembrane transporter activity
CWR56_RS14850	COG1136	(ABC) transporter
CWR56_RS14855	COG1968	undecaprenyl-diphosphatase activity
CWR56_RS14860	COG2205	protein histidine kinase activity
CWR56_RS14865	COG0745	RESPONSE REGULATOR receiver
CWR56_RS14880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR56_RS14895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWR56_RS14900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWR56_RS14910	COG1120	ATPase activity
CWR56_RS14915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR56_RS14930	COG2205	protein histidine kinase activity
CWR56_RS14935	COG0745	RESPONSE REGULATOR receiver
CWR56_RS14940	COG0577	efflux transmembrane transporter activity
CWR56_RS14945	COG1136	(ABC) transporter
CWR56_RS14960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR56_RS14965	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR56_RS14990	COG1454	alcohol dehydrogenase
CWR56_RS14995	COG1376	ErfK ybiS ycfS ynhG family protein
CWR56_RS15005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR56_RS15010	COG0785	Cytochrome C biogenesis protein
CWR56_RS15015	COG1733	regulation of RNA biosynthetic process
CWR56_RS15020	COG0383	alpha-mannosidase activity
CWR56_RS15025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15040	COG3711	transcriptional antiterminator
CWR56_RS15045	COG4975	Glucose uptake
CWR56_RS15080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWR56_RS15095	COG0517	IMP dehydrogenase activity
CWR56_RS15095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CWR56_RS15100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWR56_RS15105	COG1263	PTS System
CWR56_RS15105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15110	COG3711	transcriptional antiterminator
CWR56_RS15115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWR56_RS15120	COG3118	belongs to the thioredoxin family
CWR56_RS15130	COG0384	phenazine biosynthesis protein PhzF
CWR56_RS15150	COG0542	response to heat
CWR56_RS15160	COG2267	carboxylic ester hydrolase activity
CWR56_RS15175	COG1737	Transcriptional regulator
CWR56_RS15180	COG2971	BadF BadG BcrA BcrD
CWR56_RS15185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CWR56_RS15195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS15210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CWR56_RS15220	COG0642	Histidine kinase
CWR56_RS15235	COG1136	(ABC) transporter
CWR56_RS15245	COG2190	(PTS) system
CWR56_RS15260	COG1263	PTS System
CWR56_RS15260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15275	COG2115	Belongs to the xylose isomerase family
CWR56_RS15280	COG1070	Carbohydrate kinase
CWR56_RS15295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15300	COG3716	PTS system mannose fructose sorbose family IID component
CWR56_RS15330	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CWR56_RS15355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CWR56_RS15360	COG0191	fructose-bisphosphate aldolase activity
CWR56_RS15365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15380	COG2723	6-phospho-beta-galactosidase activity
CWR56_RS15390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS15400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15400	COG2213	PTS system mannitol-specific
CWR56_RS15405	COG1929	Belongs to the glycerate kinase type-1 family
CWR56_RS15410	COG0383	alpha-mannosidase activity
CWR56_RS15415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15425	COG3394	polysaccharide catabolic process
CWR56_RS15430	COG2190	(PTS) system
CWR56_RS15430	COG1263	PTS System
CWR56_RS15430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15435	COG2188	Transcriptional regulator
CWR56_RS15440	COG0366	Alpha amylase catalytic
CWR56_RS15450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CWR56_RS15465	COG2723	6-phospho-beta-galactosidase activity
CWR56_RS15470	COG2190	(PTS) system
CWR56_RS15470	COG1263	PTS System
CWR56_RS15470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15475	COG3711	transcriptional antiterminator
CWR56_RS15485	COG1288	antiporter activity
CWR56_RS15490	COG1263	PTS System
CWR56_RS15490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR56_RS15505	COG0561	phosphatase activity
CWR56_RS15510	COG1454	alcohol dehydrogenase
CWR56_RS15515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWR56_RS15520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15520	COG3711	transcriptional antiterminator
CWR56_RS15525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR56_RS15530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWR56_RS15535	COG0205	6-phosphofructokinase activity
CWR56_RS15545	COG1473	amidohydrolase
CWR56_RS15550	COG1473	amidohydrolase
CWR56_RS15560	COG2723	6-phospho-beta-galactosidase activity
CWR56_RS15565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15565	COG1263	PTS System
CWR56_RS15565	COG2190	(PTS) system
CWR56_RS15580	COG1819	glycosyl
CWR56_RS15585	COG3620	sequence-specific DNA binding
CWR56_RS15600	COG0640	Transcriptional regulator
CWR56_RS15610	COG2723	6-phospho-beta-galactosidase activity
CWR56_RS15615	COG2190	(PTS) system
CWR56_RS15615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15615	COG1263	PTS System
CWR56_RS15620	COG3711	transcriptional antiterminator
CWR56_RS15625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS15625	COG1263	PTS System
CWR56_RS15630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR56_RS15640	COG2723	6-phospho-beta-galactosidase activity
CWR56_RS15650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15655	COG3711	transcriptional antiterminator
CWR56_RS15660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS15660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR56_RS15665	COG0191	fructose-bisphosphate aldolase activity
CWR56_RS15685	COG0693	protein deglycase activity
CWR56_RS15700	COG4509	Sortase family
CWR56_RS15705	COG1136	(ABC) transporter
CWR56_RS15745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWR56_RS15780	COG0305	Participates in initiation and elongation during chromosome replication
CWR56_RS15800	COG3620	sequence-specific DNA binding
CWR56_RS15820	COG0582	viral genome integration into host DNA
CWR56_RS15845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CWR56_RS15870	COG1131	(ABC) transporter
CWR56_RS15880	COG0557	exoribonuclease II activity
CWR56_RS15895	COG1881	PFAM PEBP family protein
CWR56_RS15915	COG0148	phosphopyruvate hydratase activity
CWR56_RS15920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CWR56_RS15925	COG0149	triose-phosphate isomerase activity
CWR56_RS15930	COG0126	phosphoglycerate kinase activity
CWR56_RS15940	COG2390	Transcriptional regulator
CWR56_RS15945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CWR56_RS15950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWR56_RS15960	COG0167	dihydroorotate dehydrogenase activity
CWR56_RS15970	COG0402	S-adenosylhomocysteine deaminase activity
CWR56_RS15975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CWR56_RS15995	COG3829	transcription factor binding
CWR56_RS16000	COG0251	oxidation-reduction process
CWR56_RS16015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWR56_RS16020	COG0789	Transcriptional regulator
CWR56_RS16030	COG2247	cell wall binding repeat
CWR56_RS16030	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR56_RS16040	COG2207	Transcriptional regulator
CWR56_RS16045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWR56_RS16055	COG0789	Transcriptional regulator
CWR56_RS16080	COG2205	protein histidine kinase activity
CWR56_RS16080	COG2770	Histidine kinase
CWR56_RS16085	COG0745	RESPONSE REGULATOR receiver
CWR56_RS16090	COG0706	membrane insertase activity
CWR56_RS16100	COG0778	Nitroreductase
CWR56_RS16110	COG0534	Mate efflux family protein
CWR56_RS16135	COG2226	methyltransferase
CWR56_RS16155	COG1732	Glycine betaine
CWR56_RS16160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWR56_RS16170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWR56_RS16175	COG2226	methyltransferase
CWR56_RS16185	COG1473	amidohydrolase
CWR56_RS16190	COG1760	l-serine dehydratase
CWR56_RS16200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWR56_RS16205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR56_RS16210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWR56_RS16215	COG2171	N-acyltransferase activity
CWR56_RS16225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWR56_RS16235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CWR56_RS16240	COG3681	Belongs to the UPF0597 family
CWR56_RS16250	COG3829	transcription factor binding
CWR56_RS16255	COG2226	methyltransferase
CWR56_RS16280	COG0252	asparaginase activity
CWR56_RS16280	COG5275	peptidyl-tyrosine sulfation
CWR56_RS16285	COG0252	asparaginase activity
CWR56_RS16285	COG5275	peptidyl-tyrosine sulfation
CWR56_RS16300	COG5275	peptidyl-tyrosine sulfation
CWR56_RS16300	COG0252	asparaginase activity
CWR56_RS16320	COG4656	Part of a membrane complex involved in electron transport
CWR56_RS16330	COG0726	polysaccharide deacetylase
CWR56_RS16355	COG0285	dihydrofolate synthase activity
CWR56_RS16365	COG3279	Response regulator of the LytR AlgR family
CWR56_RS16370	COG0525	valine-tRNA ligase activity
CWR56_RS16380	COG0726	polysaccharide deacetylase
CWR56_RS16395	COG0704	Plays a role in the regulation of phosphate uptake
CWR56_RS16400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWR56_RS16405	COG0581	inorganic phosphate transmembrane transporter activity
CWR56_RS16410	COG0573	inorganic phosphate transmembrane transporter activity
CWR56_RS16430	COG0745	RESPONSE REGULATOR receiver
CWR56_RS16435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWR56_RS16440	COG1164	Oligoendopeptidase f
CWR56_RS16445	COG1285	pathogenesis
CWR56_RS16470	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CWR56_RS16475	COG3716	PTS system mannose fructose sorbose family IID component
CWR56_RS16480	COG3715	PTS system
CWR56_RS16485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS16485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS16490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR56_RS16490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR56_RS16500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWR56_RS16515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWR56_RS16520	COG0166	Belongs to the GPI family
CWR56_RS16530	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CWR56_RS16545	COG1405	negative regulation of cell septum assembly
CWR56_RS16545	COG3012	SEC-C Motif Domain Protein
CWR56_RS16570	COG1459	type II secretion system
CWR56_RS16575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWR56_RS16590	COG2814	Major facilitator Superfamily
CWR56_RS16595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CWR56_RS16600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CWR56_RS16610	COG2059	Chromate
CWR56_RS16615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWR56_RS16620	COG0740	serine-type endopeptidase activity
CWR56_RS16625	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWR56_RS16640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWR56_RS16660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWR56_RS16660	COG0493	'glutamate synthase
CWR56_RS16670	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWR56_RS16680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CWR56_RS16715	COG1131	(ABC) transporter
CWR56_RS16745	COG3279	Response regulator of the LytR AlgR family
CWR56_RS16775	COG0457	Tetratricopeptide repeat
CWR56_RS16775	COG0463	Glycosyl transferase, family 2
CWR56_RS16790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS16800	COG0778	Nitroreductase
CWR56_RS16805	COG1733	regulation of RNA biosynthetic process
CWR56_RS16810	COG0693	protein deglycase activity
CWR56_RS16815	COG1522	sequence-specific DNA binding
CWR56_RS16820	COG0488	(ABC) transporter
CWR56_RS16825	COG0745	RESPONSE REGULATOR receiver
CWR56_RS16845	COG4555	ABC transporter
CWR56_RS16850	COG5001	Diguanylate cyclase
CWR56_RS16900	COG0205	6-phosphofructokinase activity
CWR56_RS16910	COG1481	regulation of sporulation
CWR56_RS16925	COG1660	Displays ATPase and GTPase activities
CWR56_RS16935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWR56_RS16940	COG2116	formate transmembrane transporter activity
CWR56_RS16945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWR56_RS16975	COG0322	excinuclease ABC activity
CWR56_RS16985	COG0556	nucleotide-excision repair
CWR56_RS16995	COG1653	transport
CWR56_RS17005	COG1175	transmembrane transport
CWR56_RS17010	COG3842	ATPase activity
CWR56_RS17030	COG1648	precorrin-2 dehydrogenase activity
CWR56_RS17030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWR56_RS17035	COG0113	porphobilinogen synthase activity
CWR56_RS17045	COG0181	hydroxymethylbilane synthase activity
CWR56_RS17055	COG2099	Precorrin-6x reductase
CWR56_RS17085	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CWR56_RS17100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWR56_RS17110	COG1797	cobyrinic acid a,c-diamide synthase activity
CWR56_RS17115	COG1492	cobalamin metabolic process
CWR56_RS17120	COG0406	alpha-ribazole phosphatase activity
CWR56_RS17125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CWR56_RS17130	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CWR56_RS17135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CWR56_RS17155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWR56_RS17170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS17175	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWR56_RS17180	COG1363	Peptidase, m42
CWR56_RS17185	COG3711	transcriptional antiterminator
CWR56_RS17190	COG0191	fructose-bisphosphate aldolase activity
CWR56_RS17195	COG2222	sugar isomerase
CWR56_RS17210	COG2188	Transcriptional regulator
CWR56_RS17220	COG0793	Belongs to the peptidase S41A family
CWR56_RS17220	COG3409	Peptidoglycan-binding domain 1 protein
CWR56_RS17225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWR56_RS17235	COG3949	Membrane
CWR56_RS17240	COG3958	Transketolase
CWR56_RS17245	COG3959	Transketolase, thiamine diphosphate binding domain
CWR56_RS17250	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWR56_RS17270	COG0516	GMP reductase activity
CWR56_RS17270	COG0517	IMP dehydrogenase activity
CWR56_RS17275	COG0736	holo-[acyl-carrier-protein] synthase activity
CWR56_RS17280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWR56_RS17285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWR56_RS17290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWR56_RS17295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWR56_RS17300	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWR56_RS17305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWR56_RS17310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWR56_RS17340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CWR56_RS17340	COG3608	succinylglutamate desuccinylase aspartoacylase
CWR56_RS17345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWR56_RS17350	COG0698	ribose 5-phosphate isomerase
CWR56_RS17360	COG0009	L-threonylcarbamoyladenylate synthase
CWR56_RS17370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWR56_RS17375	COG2890	protein-(glutamine-N5) methyltransferase activity
CWR56_RS17380	COG3872	metal-dependent enzyme
CWR56_RS17385	COG0254	rRNA binding
CWR56_RS17390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CWR56_RS17395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWR56_RS17405	COG2208	phosphoserine phosphatase activity
CWR56_RS17410	COG0248	Ppx GppA phosphatase
CWR56_RS17430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CWR56_RS17440	COG3956	TIGRFAM MazG family protein
CWR56_RS17445	COG2244	polysaccharide biosynthetic process
CWR56_RS17450	COG2002	toxin-antitoxin pair type II binding
CWR56_RS17455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWR56_RS17460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWR56_RS17465	COG0193	aminoacyl-tRNA hydrolase activity
CWR56_RS17515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWR56_RS17530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWR56_RS17535	COG2088	sporulation resulting in formation of a cellular spore
CWR56_RS17540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWR56_RS17545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWR56_RS17555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWR56_RS17560	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWR56_RS17570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWR56_RS17575	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CWR56_RS17580	COG1840	ABC-type Fe3 transport system, periplasmic component
CWR56_RS17590	COG1840	ABC-type Fe3 transport system, periplasmic component
CWR56_RS17600	COG3842	ATPase activity
CWR56_RS17605	COG0613	PHP domain protein
CWR56_RS17610	COG3454	Phosphonate metabolism
CWR56_RS17615	COG4778	phosphonate C-P lyase system protein PhnL
CWR56_RS17620	COG4107	phosphonate C-P lyase system protein PhnK
CWR56_RS17625	COG3627	carbon phosphorus lyase activity
CWR56_RS17645	COG0084	hydrolase, TatD family'
CWR56_RS17650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR56_RS17650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR56_RS17655	COG0700	Nucleoside recognition
CWR56_RS17665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CWR56_RS17670	COG1522	sequence-specific DNA binding
CWR56_RS17675	COG0617	tRNA 3'-terminal CCA addition
CWR56_RS17680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CWR56_RS17685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWR56_RS17690	COG1774	PSP1 C-terminal conserved region
CWR56_RS17695	COG0470	DNA polymerase III
CWR56_RS17700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWR56_RS17705	COG1982	Orn Lys Arg decarboxylase major
CWR56_RS17710	COG2155	Conserved Protein
CWR56_RS17735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWR56_RS17740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWR56_RS17750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CWR56_RS17760	COG3191	aminopeptidase activity
CWR56_RS17770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWR56_RS17775	COG0037	tRNA processing
CWR56_RS17785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWR56_RS17800	COG1802	Transcriptional regulator
CWR56_RS17805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWR56_RS17835	COG0653	protein targeting
CWR56_RS17860	COG2271	Major facilitator Superfamily
CWR56_RS17865	COG0626	cystathionine gamma-synthase activity
CWR56_RS17890	COG0564	pseudouridine synthase activity
CWR56_RS17895	COG0789	Transcriptional regulator
CWR56_RS17895	COG4978	Transcriptional regulator
CWR56_RS17905	COG0577	efflux transmembrane transporter activity
CWR56_RS17905	COG1136	(ABC) transporter
CWR56_RS17910	COG5002	protein histidine kinase activity
CWR56_RS17930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWR56_RS17940	COG0284	orotidine-5'-phosphate decarboxylase activity
CWR56_RS17960	COG1410	methionine synthase
CWR56_RS17960	COG0646	methionine synthase
CWR56_RS17970	COG1854	S-ribosylhomocysteine lyase activity
CWR56_RS17985	COG1876	peptidase activity
CWR56_RS17990	COG0037	tRNA processing
CWR56_RS17995	COG1408	metallophosphoesterase
CWR56_RS18010	COG1141	Ferredoxin
CWR56_RS18015	COG3964	amidohydrolase
CWR56_RS18025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CWR56_RS18035	COG0346	lactoylglutathione lyase activity
CWR56_RS18040	COG0534	Mate efflux family protein
CWR56_RS18055	COG4978	Transcriptional regulator
CWR56_RS18055	COG0789	Transcriptional regulator
CWR56_RS18065	COG5504	Zn-dependent protease
CWR56_RS18075	COG0519	Catalyzes the synthesis of GMP from XMP
CWR56_RS18085	COG1357	PFAM Pentapeptide repeats (8 copies)
CWR56_RS18090	COG2824	Alkylphosphonate utilization operon protein PhnA
CWR56_RS18095	COG1136	(ABC) transporter
CWR56_RS18095	COG0577	efflux transmembrane transporter activity
CWR56_RS18105	COG5002	protein histidine kinase activity
CWR56_RS18105	COG3447	MASE1 domain protein
CWR56_RS18105	COG5001	Diguanylate cyclase
CWR56_RS18110	COG0352	thiamine-phosphate diphosphorylase activity
CWR56_RS18115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR56_RS18120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CWR56_RS18120	COG0517	IMP dehydrogenase activity
CWR56_RS18150	COG0789	Transcriptional regulator
CWR56_RS18180	COG0583	DNA-binding transcription factor activity
CWR56_RS18185	COG1522	sequence-specific DNA binding
CWR56_RS18185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWR56_RS18200	COG3964	amidohydrolase
CWR56_RS18210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS18215	COG2188	Transcriptional regulator
CWR56_RS18220	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWR56_RS18225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS18250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CWR56_RS18255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR56_RS18260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CWR56_RS18275	COG1484	DNA-dependent DNA replication
CWR56_RS18300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWR56_RS18310	COG0305	Participates in initiation and elongation during chromosome replication
CWR56_RS18315	COG0359	binds to the 23S rRNA
CWR56_RS18320	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CWR56_RS18335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWR56_RS18340	COG0629	single-stranded DNA binding
CWR56_RS18345	COG0360	Binds together with S18 to 16S ribosomal RNA
CWR56_RS18350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR56_RS18365	COG0425	Belongs to the sulfur carrier protein TusA family
CWR56_RS18380	COG1104	cysteine desulfurase activity
CWR56_RS18385	COG1475	DNA binding
CWR56_RS18390	COG1192	Involved in chromosome partitioning
CWR56_RS18395	COG1475	DNA binding
CWR56_RS18400	COG0357	Ribosomal RNA small subunit methyltransferase G
CWR56_RS18405	COG0445	tRNA wobble uridine modification
CWR56_RS18410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWR56_RS18415	COG1847	R3H domain protein
CWR56_RS18420	COG0706	membrane insertase activity
CWR56_RS18425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWR56_RS18430	COG0594	ribonuclease P activity
CWR56_RS18435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWR56_RS18440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWR56_RS18445	COG0592	DNA-directed DNA polymerase activity
CWR56_RS18455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWR56_RS18460	COG0187	DNA topoisomerase II activity
CWR56_RS18465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWR56_RS18480	COG1366	Belongs to the anti-sigma-factor antagonist family
CWR56_RS18490	COG1191	sigma factor activity
CWR56_RS18540	COG1827	regulation of RNA biosynthetic process
CWR56_RS18545	COG0668	transmembrane transport
CWR56_RS18550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWR56_RS18555	COG0590	tRNA wobble adenosine to inosine editing
CWR56_RS18570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CWR56_RS18575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CWR56_RS18580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWR56_RS18590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWR56_RS18830	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CWR56_RS18835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWR56_RS18840	COG4463	regulation of RNA biosynthetic process
CWR56_RS18845	COG3880	PFAM UvrB UvrC protein
CWR56_RS18850	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CWR56_RS18855	COG0542	response to heat
CWR56_RS18860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CWR56_RS18865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CWR56_RS18870	COG4956	integral membrane protein (PIN domain superfamily)
CWR56_RS18890	COG3507	Belongs to the glycosyl hydrolase 43 family
CWR56_RS18900	COG2390	Transcriptional regulator
CWR56_RS18905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CWR56_RS18910	COG0022	dehydrogenase e1 component
CWR56_RS18915	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWR56_RS18920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR56_RS18925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CWR56_RS18925	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CWR56_RS18935	COG3414	Phosphotransferase system galactitol-specific IIB component
CWR56_RS18940	COG3775	system Galactitol-specific IIC component
CWR56_RS18955	COG0095	Lipoate-protein ligase
CWR56_RS18960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWR56_RS18965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWR56_RS18970	COG0442	prolyl-tRNA aminoacylation
CWR56_RS18975	COG0442	prolyl-tRNA aminoacylation
CWR56_RS18980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWR56_RS18990	COG0215	cysteine-tRNA ligase activity
CWR56_RS19005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWR56_RS19010	COG3688	RNA-binding protein containing a PIN domain
CWR56_RS19020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis