locus-tag	class	description
CACET_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CACET_RS00010	COG0592	DNA-directed DNA polymerase activity
CACET_RS00015	COG2501	S4 domain
CACET_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CACET_RS00030	COG0187	DNA topoisomerase II activity
CACET_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CACET_RS00045	COG2172	sigma factor antagonist activity
CACET_RS00050	COG1191	sigma factor activity
CACET_RS00070	COG1827	regulation of RNA biosynthetic process
CACET_RS00075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CACET_RS00085	COG0157	Belongs to the NadC ModD family
CACET_RS00095	COG1615	UPF0182 protein
CACET_RS00105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CACET_RS00115	COG0590	tRNA wobble adenosine to inosine editing
CACET_RS00125	COG0425	Belongs to the sulfur carrier protein TusA family
CACET_RS00135	COG0668	transmembrane transport
CACET_RS00145	COG0360	Binds together with S18 to 16S ribosomal RNA
CACET_RS00155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CACET_RS00170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CACET_RS00205	COG1937	Protein conserved in bacteria
CACET_RS00215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CACET_RS00220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CACET_RS00225	COG0586	Pfam SNARE associated Golgi protein
CACET_RS00235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CACET_RS00240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CACET_RS00240	COG1648	precorrin-2 dehydrogenase activity
CACET_RS00245	COG0181	hydroxymethylbilane synthase activity
CACET_RS00255	COG0113	porphobilinogen synthase activity
CACET_RS00260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CACET_RS00265	COG1797	cobyrinic acid a,c-diamide synthase activity
CACET_RS00290	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CACET_RS00340	COG1982	Orn Lys Arg decarboxylase major
CACET_RS00345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CACET_RS00350	COG3870	Protein conserved in bacteria
CACET_RS00355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CACET_RS00360	COG1774	PSP1 C-terminal conserved region
CACET_RS00370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CACET_RS00375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CACET_RS00380	COG2002	toxin-antitoxin pair type II binding
CACET_RS00385	COG0617	tRNA 3'-terminal CCA addition
CACET_RS00390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CACET_RS00400	COG0700	Nucleoside recognition
CACET_RS00405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CACET_RS00405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CACET_RS00410	COG0084	hydrolase, TatD family'
CACET_RS00420	COG3583	domain protein
CACET_RS00420	COG3584	3D domain protein
CACET_RS00425	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CACET_RS00430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CACET_RS00440	COG0530	calcium, potassium:sodium antiporter activity
CACET_RS00465	COG0493	'glutamate synthase
CACET_RS00470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CACET_RS00475	COG2195	Cleaves the N-terminal amino acid of tripeptides
CACET_RS00480	COG1982	Orn Lys Arg decarboxylase major
CACET_RS00490	COG5337	Spore coat protein CotH
CACET_RS00495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CACET_RS00500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CACET_RS00505	COG2088	sporulation resulting in formation of a cellular spore
CACET_RS00510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CACET_RS00520	COG0193	aminoacyl-tRNA hydrolase activity
CACET_RS00530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CACET_RS00535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CACET_RS00540	COG2002	toxin-antitoxin pair type II binding
CACET_RS00545	COG2244	polysaccharide biosynthetic process
CACET_RS00550	COG3956	TIGRFAM MazG family protein
CACET_RS00560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CACET_RS00565	COG2385	sporulation resulting in formation of a cellular spore
CACET_RS00585	COG1098	S1 RNA binding domain
CACET_RS00590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CACET_RS00590	COG0248	Ppx GppA phosphatase
CACET_RS00595	COG2208	phosphoserine phosphatase activity
CACET_RS00625	COG0504	CTP synthase activity
CACET_RS00670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CACET_RS00675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CACET_RS00680	COG1045	serine acetyltransferase
CACET_RS00725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CACET_RS00730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CACET_RS00765	COG4584	PFAM Integrase catalytic
CACET_RS00765	COG2390	Transcriptional regulator
CACET_RS00785	COG0758	DNA mediated transformation
CACET_RS00800	COG1316	TRANSCRIPTIONal
CACET_RS00810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CACET_RS00825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CACET_RS00835	COG0463	Glycosyl transferase, family 2
CACET_RS00850	COG0463	Glycosyl transferase, family 2
CACET_RS00880	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CACET_RS00885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CACET_RS00890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CACET_RS00900	COG0131	Imidazoleglycerol-phosphate dehydratase
CACET_RS00905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CACET_RS00910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CACET_RS00915	COG0107	imidazoleglycerol-phosphate synthase activity
CACET_RS00920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CACET_RS00920	COG0140	phosphoribosyl-ATP diphosphatase activity
CACET_RS00925	COG0733	neurotransmitter:sodium symporter activity
CACET_RS00930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CACET_RS00935	COG1494	fructose-1,6-bisphosphatase
CACET_RS00940	COG1494	fructose-1,6-bisphosphatase
CACET_RS00945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CACET_RS00950	COG0254	rRNA binding
CACET_RS00955	COG1435	thymidine kinase activity
CACET_RS00965	COG3872	metal-dependent enzyme
CACET_RS00970	COG2890	protein-(glutamine-N5) methyltransferase activity
CACET_RS00975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CACET_RS00985	COG0428	transporter
CACET_RS00990	COG1716	ATPase activity
CACET_RS01000	COG0768	penicillin binding
CACET_RS01005	COG0009	L-threonylcarbamoyladenylate synthase
CACET_RS01015	COG0698	ribose 5-phosphate isomerase
CACET_RS01020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CACET_RS01030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CACET_RS01035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CACET_RS01050	COG0356	it plays a direct role in the translocation of protons across the membrane
CACET_RS01065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CACET_RS01070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CACET_RS01075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CACET_RS01080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CACET_RS01085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CACET_RS01090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CACET_RS01110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CACET_RS01115	COG2385	sporulation resulting in formation of a cellular spore
CACET_RS01125	COG1609	Transcriptional regulator
CACET_RS01130	COG1077	Cell shape determining protein MreB Mrl
CACET_RS01135	COG4786	Flagellar basal body rod
CACET_RS01150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CACET_RS01160	COG1082	Xylose isomerase domain protein TIM barrel
CACET_RS01165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CACET_RS01175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CACET_RS01180	COG0745	RESPONSE REGULATOR receiver
CACET_RS01185	COG5002	protein histidine kinase activity
CACET_RS01205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CACET_RS01220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CACET_RS01245	COG4786	Flagellar basal body rod
CACET_RS01245	COG1256	bacterial-type flagellum assembly
CACET_RS01260	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CACET_RS01265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CACET_RS01350	COG1516	flagellar protein fliS
CACET_RS01360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CACET_RS01370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CACET_RS01395	COG0248	Ppx GppA phosphatase
CACET_RS01400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CACET_RS01410	COG2972	Histidine kinase
CACET_RS01415	COG2207	Transcriptional regulator
CACET_RS01415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CACET_RS01420	COG0129	dihydroxy-acid dehydratase activity
CACET_RS01425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CACET_RS01430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS01430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CACET_RS01435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CACET_RS01435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS01455	COG0411	ABC transporter
CACET_RS01465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CACET_RS01495	COG2204	response regulator
CACET_RS01500	COG0786	glutamate:sodium symporter activity
CACET_RS01530	COG0653	protein targeting
CACET_RS01535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CACET_RS01540	COG0840	transmembrane signaling receptor activity
CACET_RS01555	COG2257	FlhB HrpN YscU SpaS Family
CACET_RS01575	COG2183	response to ionizing radiation
CACET_RS01580	COG1129	ABC transporter
CACET_RS01585	COG2201	protein-glutamate methylesterase activity
CACET_RS01590	COG1879	ABC-type sugar transport system periplasmic component
CACET_RS01595	COG1129	ABC transporter
CACET_RS01600	COG1172	Belongs to the binding-protein-dependent transport system permease family
CACET_RS01605	COG1063	alcohol dehydrogenase
CACET_RS01610	COG1070	Carbohydrate kinase
CACET_RS01620	COG0561	phosphatase activity
CACET_RS01635	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CACET_RS01645	COG0802	atpase or kinase
CACET_RS01650	COG1214	PFAM Peptidase M22, glycoprotease
CACET_RS01655	COG0456	acetyltransferase
CACET_RS01665	COG0577	efflux transmembrane transporter activity
CACET_RS01670	COG0577	efflux transmembrane transporter activity
CACET_RS01675	COG1136	(ABC) transporter
CACET_RS01680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CACET_RS01685	COG0488	(ABC) transporter
CACET_RS01690	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CACET_RS01700	COG2221	Nitrite and sulphite reductase 4Fe-4S
CACET_RS01730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CACET_RS01755	COG1811	Na channel or pump
CACET_RS01760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CACET_RS01765	COG0459	protein refolding
CACET_RS01790	COG0517	IMP dehydrogenase activity
CACET_RS01790	COG0516	GMP reductase activity
CACET_RS01795	COG0519	Catalyzes the synthesis of GMP from XMP
CACET_RS01795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CACET_RS01800	COG2252	PERMEase
CACET_RS01805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CACET_RS01810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CACET_RS01820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CACET_RS01825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CACET_RS01830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CACET_RS01835	COG0138	bifunctional purine biosynthesis protein purh
CACET_RS01840	COG0151	Belongs to the GarS family
CACET_RS01845	COG3852	Histidine kinase
CACET_RS01850	COG2204	response regulator
CACET_RS01855	COG2358	TRAP transporter, solute receptor (TAXI family
CACET_RS01870	COG0840	transmembrane signaling receptor activity
CACET_RS01880	COG1464	Belongs to the NlpA lipoprotein family
CACET_RS01885	COG2011	ABC-type metal ion transport system permease component
CACET_RS01890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CACET_RS01895	COG4496	protein, YerC YecD
CACET_RS01900	COG0527	aspartate kinase activity
CACET_RS01905	COG2086	electron transfer activity
CACET_RS01910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CACET_RS01920	COG3949	Membrane
CACET_RS01935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CACET_RS01970	COG4303	Ethanolamine ammonia lyase large subunit
CACET_RS01990	COG1454	alcohol dehydrogenase
CACET_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
CACET_RS02000	COG4812	Cobalamin adenosyltransferase
CACET_RS02005	COG4869	propanediol catabolic process
CACET_RS02020	COG4656	Part of a membrane complex involved in electron transport
CACET_RS02030	COG3192	ethanolamine utilization protein
CACET_RS02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CACET_RS02050	COG0437	4 iron, 4 sulfur cluster binding
CACET_RS02070	COG5012	cobalamin binding
CACET_RS02090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CACET_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
CACET_RS02110	COG1250	3-hydroxyacyl-CoA dehydrogenase
CACET_RS02120	COG0183	Belongs to the thiolase family
CACET_RS02125	COG3246	L-lysine catabolic process to acetate
CACET_RS02135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CACET_RS02145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CACET_RS02145	COG0512	Glutamine amidotransferase of anthranilate synthase
CACET_RS02150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CACET_RS02155	COG0134	indole-3-glycerol-phosphate synthase activity
CACET_RS02160	COG0135	phosphoribosylanthranilate isomerase activity
CACET_RS02165	COG0133	tryptophan synthase activity
CACET_RS02170	COG0159	tryptophan synthase activity
CACET_RS02175	COG0287	Prephenate dehydrogenase
CACET_RS02180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CACET_RS02185	COG1605	Chorismate mutase
CACET_RS02185	COG0077	Prephenate dehydratase
CACET_RS02190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CACET_RS02195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CACET_RS02200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CACET_RS02205	COG5002	protein histidine kinase activity
CACET_RS02215	COG0303	'Molybdopterin
CACET_RS02225	COG0210	DNA helicase
CACET_RS02230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CACET_RS02245	COG1592	Rubrerythrin
CACET_RS02255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CACET_RS02280	COG2247	cell wall binding repeat
CACET_RS02280	COG0860	N-Acetylmuramoyl-L-alanine amidase
CACET_RS02285	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CACET_RS02295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CACET_RS02300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CACET_RS02305	COG0622	Phosphoesterase
CACET_RS02350	COG0840	transmembrane signaling receptor activity
CACET_RS02360	COG0745	RESPONSE REGULATOR receiver
CACET_RS02365	COG5002	protein histidine kinase activity
CACET_RS02370	COG2226	methyltransferase
CACET_RS02380	COG0697	spore germination
CACET_RS02395	COG0475	glutathione-regulated potassium exporter activity
CACET_RS02400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CACET_RS02410	COG5002	protein histidine kinase activity
CACET_RS02415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CACET_RS02425	COG1126	abc transporter atp-binding protein
CACET_RS02430	COG1063	alcohol dehydrogenase
CACET_RS02435	COG0321	lipoyl(octanoyl) transferase activity
CACET_RS02440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CACET_RS02455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CACET_RS02460	COG0022	dehydrogenase e1 component
CACET_RS02465	COG3199	ATP-NAD kinase
CACET_RS02470	COG0508	dehydrogenase complex catalyzes the overall conversion of
CACET_RS02475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CACET_RS02485	COG1666	GTP binding
CACET_RS02490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CACET_RS02495	COG3459	Glycosyltransferase 36 associated
CACET_RS02510	COG1131	(ABC) transporter
CACET_RS02515	COG1725	Transcriptional regulator
CACET_RS02530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CACET_RS02545	COG2247	cell wall binding repeat
CACET_RS02545	COG0860	N-Acetylmuramoyl-L-alanine amidase
CACET_RS02555	COG0124	histidyl-tRNA synthetase
CACET_RS02570	COG1122	ATPase activity
CACET_RS02575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CACET_RS02580	COG0803	Belongs to the bacterial solute-binding protein 9 family
CACET_RS02585	COG1121	(ABC) transporter
CACET_RS02590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CACET_RS02595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CACET_RS02615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CACET_RS02620	COG0840	transmembrane signaling receptor activity
CACET_RS02625	COG0473	3-isopropylmalate dehydrogenase activity
CACET_RS02630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CACET_RS02635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CACET_RS02640	COG0835	chemotaxis
CACET_RS02645	COG0420	3'-5' exonuclease activity
CACET_RS02650	COG0419	ATPase involved in DNA repair
CACET_RS02665	COG0012	GTP binding
CACET_RS02670	COG1691	(AIR) carboxylase
CACET_RS02675	COG1606	tRNA processing
CACET_RS02680	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CACET_RS02695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CACET_RS02700	COG2011	ABC-type metal ion transport system permease component
CACET_RS02705	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CACET_RS02725	COG0674	pyruvate-flavodoxin oxidoreductase activity
CACET_RS02730	COG1013	pyruvate-flavodoxin oxidoreductase activity
CACET_RS02735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CACET_RS02745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CACET_RS02755	COG2210	Belongs to the sulfur carrier protein TusA family
CACET_RS02760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CACET_RS02765	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CACET_RS02770	COG5002	protein histidine kinase activity
CACET_RS02770	COG0784	Response regulator, receiver
CACET_RS02775	COG1609	Transcriptional regulator
CACET_RS02780	COG0544	peptidyl-prolyl cis-trans isomerase activity
CACET_RS02785	COG0740	serine-type endopeptidase activity
CACET_RS02790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CACET_RS02795	COG2059	Chromate
CACET_RS02800	COG2059	Chromate
CACET_RS02805	COG1067	ATP-dependent peptidase activity
CACET_RS02805	COG0470	DNA polymerase III
CACET_RS02810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CACET_RS02815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CACET_RS02820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CACET_RS02825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CACET_RS02835	COG0540	Belongs to the ATCase OTCase family
CACET_RS02865	COG5002	protein histidine kinase activity
CACET_RS02865	COG3850	Histidine kinase
CACET_RS02875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CACET_RS02890	COG1924	4 iron, 4 sulfur cluster binding
CACET_RS02925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CACET_RS02930	COG2226	methyltransferase
CACET_RS02955	COG0798	PFAM Bile acid sodium symporter
CACET_RS03000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CACET_RS03010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CACET_RS03015	COG1151	hydroxylamine reductase activity
CACET_RS03020	COG1940	carbohydrate kinase activity
CACET_RS03025	COG1058	Belongs to the CinA family
CACET_RS03025	COG1546	Belongs to the CinA family
CACET_RS03040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CACET_RS03080	COG4242	Belongs to the peptidase S51 family
CACET_RS03110	COG1376	ErfK ybiS ycfS ynhG family protein
CACET_RS03120	COG5002	protein histidine kinase activity
CACET_RS03125	COG0004	ammonium transporteR
CACET_RS03130	COG0347	Belongs to the P(II) protein family
CACET_RS03135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CACET_RS03140	COG1285	pathogenesis
CACET_RS03150	COG3292	Two component regulator propeller
CACET_RS03150	COG2205	protein histidine kinase activity
CACET_RS03150	COG0745	RESPONSE REGULATOR receiver
CACET_RS03160	COG1414	Transcriptional regulator
CACET_RS03165	COG0800	Aldolase
CACET_RS03170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CACET_RS03175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CACET_RS03185	COG1609	Transcriptional regulator
CACET_RS03190	COG0371	Dehydrogenase
CACET_RS03195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CACET_RS03200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS03205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CACET_RS03210	COG0129	dihydroxy-acid dehydratase activity
CACET_RS03215	COG4948	Mandelate Racemase Muconate Lactonizing
CACET_RS03245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CACET_RS03250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CACET_RS03255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CACET_RS03260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CACET_RS03285	COG2378	regulation of single-species biofilm formation
CACET_RS03325	COG3655	Transcriptional regulator
CACET_RS03335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CACET_RS03340	COG0745	RESPONSE REGULATOR receiver
CACET_RS03345	COG5002	protein histidine kinase activity
CACET_RS03355	COG0067	glutamate synthase
CACET_RS03355	COG0069	glutamate synthase activity
CACET_RS03355	COG0070	glutamate synthase
CACET_RS03365	COG1592	Rubrerythrin
CACET_RS03365	COG1773	rubredoxin
CACET_RS03370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CACET_RS03375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CACET_RS03380	COG1116	anion transmembrane transporter activity
CACET_RS03385	COG0840	transmembrane signaling receptor activity
CACET_RS03400	COG0133	tryptophan synthase activity
CACET_RS03405	COG2268	Band 7 protein
CACET_RS03415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CACET_RS03425	COG0745	RESPONSE REGULATOR receiver
CACET_RS03430	COG2770	Histidine kinase
CACET_RS03430	COG2205	protein histidine kinase activity
CACET_RS03440	COG4536	flavin adenine dinucleotide binding
CACET_RS03450	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CACET_RS03455	COG3639	organic phosphonate transmembrane transporter activity
CACET_RS03460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CACET_RS03475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CACET_RS03500	COG0527	aspartate kinase activity
CACET_RS03510	COG1073	alpha beta
CACET_RS03525	COG0561	phosphatase activity
CACET_RS03535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CACET_RS03545	COG2502	aspartate--ammonia ligase
CACET_RS03550	COG1217	gtp-binding protein TYPA
CACET_RS03555	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CACET_RS03570	COG3118	belongs to the thioredoxin family
CACET_RS03605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CACET_RS03610	COG1309	transcriptional regulator
CACET_RS03630	COG1924	4 iron, 4 sulfur cluster binding
CACET_RS03640	COG3872	metal-dependent enzyme
CACET_RS03645	COG0477	Major facilitator Superfamily
CACET_RS03670	COG0772	Belongs to the SEDS family
CACET_RS03675	COG2239	Acts as a magnesium transporter
CACET_RS03685	COG2959	enzyme of heme biosynthesis
CACET_RS03690	COG0179	Fumarylacetoacetate (FAA) hydrolase
CACET_RS03695	COG1509	lysine 2,3-aminomutase activity
CACET_RS03710	COG0166	Belongs to the GPI family
CACET_RS03715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CACET_RS03720	COG3275	phosphorelay sensor kinase activity
CACET_RS03740	COG2244	polysaccharide biosynthetic process
CACET_RS03760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CACET_RS03770	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CACET_RS03780	COG1129	ABC transporter
CACET_RS03795	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CACET_RS03805	COG0446	pyridine nucleotide-disulphide oxidoreductase
CACET_RS03820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CACET_RS03835	COG0525	valine-tRNA ligase activity
CACET_RS03840	COG0285	dihydrofolate synthase activity
CACET_RS03855	COG2323	membrane
CACET_RS03865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CACET_RS03885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CACET_RS03900	COG0500	methyltransferase
CACET_RS03905	COG0747	negative chemotaxis
CACET_RS03910	COG0601	transmembrane transport
CACET_RS03930	COG1283	sodium-dependent phosphate transmembrane transporter activity
CACET_RS03935	COG1268	BioY protein
CACET_RS03940	COG0726	polysaccharide deacetylase
CACET_RS03960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CACET_RS03965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CACET_RS03980	COG1132	(ABC) transporter
CACET_RS04000	COG4585	Histidine kinase
CACET_RS04010	COG1053	succinate dehydrogenase
CACET_RS04020	COG2350	Protein conserved in bacteria
CACET_RS04070	COG2197	response regulator
CACET_RS04105	COG2274	protein secretion by the type I secretion system
CACET_RS04140	COG2801	Transposase and inactivated derivatives
CACET_RS04150	COG0582	viral genome integration into host DNA
CACET_RS04160	COG4974	Belongs to the 'phage' integrase family
CACET_RS04165	COG3381	protein complex oligomerization
CACET_RS04170	COG0243	molybdopterin cofactor binding
CACET_RS04185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CACET_RS04190	COG0805	protein transport
CACET_RS04220	COG0393	Putative heavy-metal-binding
CACET_RS04225	COG1983	PspC domain protein
CACET_RS04255	COG1122	ATPase activity
CACET_RS04260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CACET_RS04270	COG2815	serine threonine protein kinase
CACET_RS04270	COG0515	serine threonine protein kinase
CACET_RS04295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CACET_RS04300	COG1120	ATPase activity
CACET_RS04325	COG1321	iron dependent repressor
CACET_RS04335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CACET_RS04340	COG1349	DNA-binding transcription factor activity
CACET_RS04345	COG3395	kinase activity
CACET_RS04355	COG2610	gluconate transmembrane transporter activity
CACET_RS04380	COG4585	Histidine kinase
CACET_RS04380	COG2203	Gaf domain
CACET_RS04385	COG2197	response regulator
CACET_RS04415	COG2094	Belongs to the DNA glycosylase MPG family
CACET_RS04420	COG0204	Acyl-transferase
CACET_RS04425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CACET_RS04435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CACET_RS04440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CACET_RS04445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CACET_RS04450	COG2171	N-acyltransferase activity
CACET_RS04455	COG0527	aspartate kinase activity
CACET_RS04460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CACET_RS04470	COG1943	Transposase
CACET_RS04480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CACET_RS04485	COG1151	hydroxylamine reductase activity
CACET_RS04490	COG0840	transmembrane signaling receptor activity
CACET_RS04495	COG0653	protein targeting
CACET_RS04505	COG3290	protein histidine kinase activity
CACET_RS04505	COG0840	transmembrane signaling receptor activity
CACET_RS04510	COG1418	mRNA catabolic process
CACET_RS04525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CACET_RS04530	COG0302	gtp cyclohydrolase
CACET_RS04535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CACET_RS04540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CACET_RS04545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CACET_RS04550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CACET_RS04560	COG0482	sulfurtransferase activity
CACET_RS04565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CACET_RS04565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CACET_RS04580	COG3546	catalase activity
CACET_RS04585	COG2339	peptidase activity
CACET_RS04605	COG0517	IMP dehydrogenase activity
CACET_RS04610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CACET_RS04615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CACET_RS04625	COG0697	spore germination
CACET_RS04630	COG0681	Belongs to the peptidase S26 family
CACET_RS04635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CACET_RS04640	COG1067	ATP-dependent peptidase activity
CACET_RS04645	COG0156	8-amino-7-oxononanoate synthase activity
CACET_RS04665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CACET_RS04675	COG2720	vancomycin resistance protein
CACET_RS04685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CACET_RS04695	COG2340	Cysteine-rich secretory protein family
CACET_RS04700	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CACET_RS04710	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CACET_RS04715	COG0406	alpha-ribazole phosphatase activity
CACET_RS04720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CACET_RS04725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CACET_RS04730	COG1120	ATPase activity
CACET_RS04735	COG1492	cobalamin metabolic process
CACET_RS04750	COG0735	belongs to the Fur family
CACET_RS04755	COG0561	phosphatase activity
CACET_RS04770	COG1307	EDD domain protein, DegV family
CACET_RS04790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CACET_RS04795	COG2171	N-acyltransferase activity
CACET_RS04815	COG1278	Cold shock
CACET_RS04820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CACET_RS04845	COG0440	acetolactate synthase activity
CACET_RS04850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CACET_RS04855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CACET_RS04860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CACET_RS04865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CACET_RS04870	COG0066	3-isopropylmalate dehydratase activity
CACET_RS04875	COG0473	3-isopropylmalate dehydrogenase activity
CACET_RS04880	COG0028	Belongs to the TPP enzyme family
CACET_RS04890	COG1959	2 iron, 2 sulfur cluster binding
CACET_RS04905	COG4399	Belongs to the UPF0754 family
CACET_RS04910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CACET_RS04925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CACET_RS04930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CACET_RS04935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CACET_RS04940	COG0569	domain protein
CACET_RS04945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CACET_RS04950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CACET_RS04955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CACET_RS04955	COG0072	phenylalanine-tRNA ligase activity
CACET_RS04965	COG0826	peptidase U32
CACET_RS04970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CACET_RS04975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CACET_RS04980	COG1472	Belongs to the glycosyl hydrolase 3 family
CACET_RS04990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CACET_RS04990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CACET_RS04990	COG1013	pyruvate-flavodoxin oxidoreductase activity
CACET_RS04990	COG0674	pyruvate-flavodoxin oxidoreductase activity
CACET_RS05005	COG3850	Histidine kinase
CACET_RS05005	COG2205	protein histidine kinase activity
CACET_RS05005	COG4999	Histidine kinase
CACET_RS05005	COG3437	response regulator, receiver
CACET_RS05015	COG1151	hydroxylamine reductase activity
CACET_RS05025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CACET_RS05030	COG3404	Formiminotransferase-cyclodeaminase
CACET_RS05035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CACET_RS05050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CACET_RS05080	COG0509	glycine decarboxylation via glycine cleavage system
CACET_RS05120	COG0321	lipoyl(octanoyl) transferase activity
CACET_RS05125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CACET_RS05135	COG0039	L-malate dehydrogenase activity
CACET_RS05140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CACET_RS05180	COG1518	maintenance of DNA repeat elements
CACET_RS05185	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CACET_RS05190	COG1193	negative regulation of DNA recombination
CACET_RS05195	COG1683	Conserved Protein
CACET_RS05200	COG0018	arginyl-trna synthetase
CACET_RS05235	COG3608	succinylglutamate desuccinylase aspartoacylase
CACET_RS05235	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CACET_RS05240	COG0280	phosphate acetyltransferase
CACET_RS05470	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CACET_RS05475	COG0587	DNA-directed DNA polymerase activity
CACET_RS05495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CACET_RS05505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS05505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CACET_RS05530	COG1802	Transcriptional regulator
CACET_RS05535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CACET_RS05545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CACET_RS05545	COG3608	succinylglutamate desuccinylase aspartoacylase
CACET_RS05560	COG2080	2 iron, 2 sulfur cluster binding
CACET_RS05560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CACET_RS05610	COG2721	sulfolactate sulfo-lyase activity
CACET_RS05615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CACET_RS05620	COG2084	Dehydrogenase
CACET_RS05625	COG4948	Mandelate Racemase Muconate Lactonizing
CACET_RS05630	COG3835	regulator
CACET_RS05635	COG2379	hydroxypyruvate reductase
CACET_RS05645	COG0436	Aminotransferase
CACET_RS05650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CACET_RS05655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CACET_RS05670	COG0488	(ABC) transporter
CACET_RS05680	COG0488	(ABC) transporter
CACET_RS05700	COG0037	tRNA processing
CACET_RS05720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CACET_RS05725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS05730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CACET_RS05730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS05740	COG1904	glucuronate isomerase
CACET_RS05745	COG1312	Catalyzes the dehydration of D-mannonate
CACET_RS05750	COG0246	Mannitol dehydrogenase
CACET_RS05755	COG1131	(ABC) transporter
CACET_RS05770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CACET_RS05805	COG0519	Catalyzes the synthesis of GMP from XMP
CACET_RS05810	COG0840	transmembrane signaling receptor activity
CACET_RS05815	COG0288	reversible hydration of carbon dioxide
CACET_RS05820	COG5002	protein histidine kinase activity
CACET_RS05825	COG0745	RESPONSE REGULATOR receiver
CACET_RS05830	COG2204	response regulator
CACET_RS05835	COG0569	domain protein
CACET_RS05850	COG0569	domain protein
CACET_RS05855	COG5002	protein histidine kinase activity
CACET_RS05860	COG2204	response regulator
CACET_RS05870	COG3048	D-serine ammonia-lyase activity
CACET_RS05880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CACET_RS05880	COG2199	diguanylate cyclase activity
CACET_RS05885	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CACET_RS05895	COG2323	membrane
CACET_RS05905	COG1396	sequence-specific DNA binding
CACET_RS05910	COG0745	RESPONSE REGULATOR receiver
CACET_RS05920	COG1136	(ABC) transporter
CACET_RS05935	COG1131	(ABC) transporter
CACET_RS05950	COG1725	Transcriptional regulator
CACET_RS05980	COG1454	alcohol dehydrogenase
CACET_RS05995	COG0697	spore germination
CACET_RS06015	COG1307	EDD domain protein, DegV family
CACET_RS06030	COG3118	belongs to the thioredoxin family
CACET_RS06050	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CACET_RS06080	COG0126	phosphoglycerate kinase activity
CACET_RS06085	COG0149	triose-phosphate isomerase activity
CACET_RS06090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CACET_RS06095	COG0148	phosphopyruvate hydratase activity
CACET_RS06100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CACET_RS06115	COG0557	exoribonuclease II activity
CACET_RS06125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CACET_RS06155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CACET_RS06180	COG1388	LysM domain
CACET_RS06180	COG3942	CHAP domain
CACET_RS06220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CACET_RS06225	COG0581	inorganic phosphate transmembrane transporter activity
CACET_RS06230	COG0573	inorganic phosphate transmembrane transporter activity
CACET_RS06235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CACET_RS06240	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CACET_RS06245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CACET_RS06260	COG0003	Pfam Anion-transporting ATPase
CACET_RS06270	COG0003	Pfam Anion-transporting ATPase
CACET_RS06275	COG1720	tRNA m6t6A37 methyltransferase activity
CACET_RS06280	COG3708	Transcriptional regulator
CACET_RS06280	COG2207	Transcriptional regulator
CACET_RS06285	COG0534	Mate efflux family protein
CACET_RS06300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CACET_RS06315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CACET_RS06325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CACET_RS06330	COG1129	ABC transporter
CACET_RS06335	COG1172	Belongs to the binding-protein-dependent transport system permease family
CACET_RS06380	COG1309	transcriptional regulator
CACET_RS06390	COG5012	cobalamin binding
CACET_RS06405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CACET_RS06420	COG0835	chemotaxis
CACET_RS06420	COG0784	Response regulator, receiver
CACET_RS06445	COG0840	transmembrane signaling receptor activity
CACET_RS06470	COG2358	TRAP transporter, solute receptor (TAXI family
CACET_RS06485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CACET_RS06490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CACET_RS06495	COG1984	allophanate hydrolase subunit 2
CACET_RS06510	COG0745	RESPONSE REGULATOR receiver
CACET_RS06535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CACET_RS06560	COG0471	metal ion transport
CACET_RS06565	COG0529	Catalyzes the synthesis of activated sulfate
CACET_RS06570	COG1053	succinate dehydrogenase
CACET_RS06580	COG0175	sulfate reduction
CACET_RS06595	COG0726	polysaccharide deacetylase
CACET_RS06600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CACET_RS06610	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CACET_RS06615	COG0156	8-amino-7-oxononanoate synthase activity
CACET_RS06620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CACET_RS06630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CACET_RS06650	COG1609	Transcriptional regulator
CACET_RS06655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CACET_RS06660	COG1744	ABC transporter substrate-binding protein PnrA-like
CACET_RS06665	COG3845	ABC transporter
CACET_RS06670	COG4603	Belongs to the binding-protein-dependent transport system permease family
CACET_RS06675	COG1079	Belongs to the binding-protein-dependent transport system permease family
CACET_RS06680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CACET_RS06695	COG0601	transmembrane transport
CACET_RS06710	COG1124	(ABC) transporter
CACET_RS06715	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CACET_RS06725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CACET_RS06730	COG1349	DNA-binding transcription factor activity
CACET_RS06740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CACET_RS06740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CACET_RS06740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CACET_RS06750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CACET_RS06765	COG3850	Histidine kinase
CACET_RS06765	COG5002	protein histidine kinase activity
CACET_RS06780	COG0069	glutamate synthase activity
CACET_RS06780	COG0070	glutamate synthase
CACET_RS06780	COG0067	glutamate synthase
CACET_RS06800	COG1119	ATPase activity
CACET_RS06810	COG1406	Chemotaxis phosphatase CheX
CACET_RS06820	COG0514	ATP-dependent DNA helicase (RecQ)
CACET_RS06830	COG1606	tRNA processing
CACET_RS06855	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CACET_RS06865	COG0347	Belongs to the P(II) protein family
CACET_RS06900	COG0725	ABC transporter, periplasmic molybdate-binding protein
CACET_RS06905	COG4149	molybdate abc transporter
CACET_RS06910	COG3842	ATPase activity
CACET_RS06915	COG0840	transmembrane signaling receptor activity
CACET_RS06935	COG1272	protein, Hemolysin III
CACET_RS06950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CACET_RS06955	COG0564	pseudouridine synthase activity
CACET_RS06975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CACET_RS06980	COG0303	'Molybdopterin
CACET_RS06985	COG0303	'Molybdopterin
CACET_RS06995	COG1796	DNA polymerase
CACET_RS06995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CACET_RS07005	COG2199	diguanylate cyclase activity
CACET_RS07020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CACET_RS07025	COG2235	arginine
CACET_RS07030	COG1132	(ABC) transporter
CACET_RS07035	COG1132	(ABC) transporter
CACET_RS07045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CACET_RS07050	COG1597	lipid kinase activity
CACET_RS07055	COG3706	GGDEF domain
CACET_RS07065	COG2986	histidine ammonia-lyase
CACET_RS07100	COG0583	DNA-binding transcription factor activity
CACET_RS07145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CACET_RS07145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CACET_RS07150	COG0237	dephospho-CoA kinase activity
CACET_RS07160	COG0747	negative chemotaxis
CACET_RS07170	COG4895	conserved protein (DUF2196)
CACET_RS07230	COG4895	conserved protein (DUF2196)
CACET_RS07240	COG2721	sulfolactate sulfo-lyase activity
CACET_RS07250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CACET_RS07270	COG1671	Belongs to the UPF0178 family
CACET_RS07350	COG1104	cysteine desulfurase activity
CACET_RS07355	COG0301	tRNA thio-modification
CACET_RS07360	COG0315	cyclic pyranopterin monophosphate synthase activity
CACET_RS07365	COG0521	Mo-molybdopterin cofactor biosynthetic process
CACET_RS07370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CACET_RS07380	COG1366	Belongs to the anti-sigma-factor antagonist family
CACET_RS07385	COG2172	sigma factor antagonist activity
CACET_RS07390	COG1191	sigma factor activity
CACET_RS07410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CACET_RS07460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CACET_RS07495	COG1396	sequence-specific DNA binding
CACET_RS07575	COG0582	viral genome integration into host DNA
CACET_RS07600	COG0740	serine-type endopeptidase activity
CACET_RS07715	COG0860	N-Acetylmuramoyl-L-alanine amidase
CACET_RS07830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CACET_RS07840	COG1739	Uncharacterized protein family UPF0029
CACET_RS07855	COG0730	response to heat
CACET_RS07860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CACET_RS07865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CACET_RS07870	COG0217	transcriptional regulatory protein
CACET_RS07880	COG0531	amino acid
CACET_RS07885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CACET_RS07890	COG2508	Transcriptional regulator
CACET_RS07895	COG1959	2 iron, 2 sulfur cluster binding
CACET_RS07900	COG1151	hydroxylamine reductase activity
CACET_RS07910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CACET_RS07915	COG1854	S-ribosylhomocysteine lyase activity
CACET_RS07920	COG0791	NLP P60 protein
CACET_RS07925	COG0741	lytic transglycosylase activity
CACET_RS07955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CACET_RS07955	COG4191	Histidine kinase
CACET_RS07960	COG4656	Part of a membrane complex involved in electron transport
CACET_RS07965	COG4658	electron transport chain
CACET_RS07970	COG4659	FMN binding
CACET_RS07975	COG4660	Part of a membrane complex involved in electron transport
CACET_RS07980	COG4657	Part of a membrane complex involved in electron transport
CACET_RS07985	COG2878	Part of a membrane complex involved in electron transport
CACET_RS07985	COG1245	4Fe-4S binding domain
CACET_RS08000	COG0424	maF-like protein
CACET_RS08005	COG2003	Belongs to the UPF0758 family
CACET_RS08010	COG1077	Cell shape determining protein MreB Mrl
CACET_RS08025	COG0768	penicillin binding
CACET_RS08030	COG0850	regulation of cytokinetic process
CACET_RS08035	COG2894	cell division
CACET_RS08040	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CACET_RS08045	COG1803	Methylglyoxal synthase
CACET_RS08055	COG1994	Peptidase M50
CACET_RS08075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CACET_RS08085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CACET_RS08090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CACET_RS08105	COG2070	2-Nitropropane dioxygenase
CACET_RS08115	COG1713	HD superfamily hydrolase involved in NAD metabolism
CACET_RS08120	COG1316	TRANSCRIPTIONal
CACET_RS08125	COG0530	calcium, potassium:sodium antiporter activity
CACET_RS08130	COG0799	negative regulation of ribosome biogenesis
CACET_RS08135	COG0495	leucyl-tRNA aminoacylation
CACET_RS08145	COG0251	oxidation-reduction process
CACET_RS08150	COG1760	l-serine dehydratase
CACET_RS08155	COG1760	l-serine dehydratase
CACET_RS08160	COG1686	Belongs to the peptidase S11 family
CACET_RS08170	COG0709	Synthesizes selenophosphate from selenide and ATP
CACET_RS08175	COG1115	amino acid carrier protein
CACET_RS08180	COG1921	L-seryl-tRNASec selenium transferase activity
CACET_RS08190	COG2323	membrane
CACET_RS08195	COG0038	chloride channel
CACET_RS08205	COG1304	FMN binding
CACET_RS08210	COG1882	Formate acetyltransferase
CACET_RS08215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CACET_RS08225	COG2972	Histidine kinase
CACET_RS08230	COG1454	alcohol dehydrogenase
CACET_RS08280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CACET_RS08290	COG3973	AAA domain
CACET_RS08310	COG0745	RESPONSE REGULATOR receiver
CACET_RS08315	COG2205	protein histidine kinase activity
CACET_RS08320	COG1136	(ABC) transporter
CACET_RS08325	COG0577	efflux transmembrane transporter activity
CACET_RS08345	COG1027	Aspartate ammonia-lyase
CACET_RS08350	COG1160	GTP binding
CACET_RS08355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CACET_RS08360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CACET_RS08370	COG0842	Transport permease protein
CACET_RS08375	COG1131	(ABC) transporter
CACET_RS08380	COG2155	Conserved Protein
CACET_RS08390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CACET_RS08395	COG0632	four-way junction helicase activity
CACET_RS08400	COG2255	four-way junction helicase activity
CACET_RS08410	COG2247	cell wall binding repeat
CACET_RS08410	COG2385	sporulation resulting in formation of a cellular spore
CACET_RS08425	COG1862	Preprotein translocase
CACET_RS08445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CACET_RS08450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CACET_RS08460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CACET_RS08460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CACET_RS08465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CACET_RS08470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CACET_RS08475	COG1490	D-aminoacyl-tRNA deacylase activity
CACET_RS08480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CACET_RS08485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CACET_RS08495	COG3266	domain, Protein
CACET_RS08495	COG2911	Protein conserved in bacteria
CACET_RS08495	COG1361	Conserved repeat domain
CACET_RS08500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CACET_RS08520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CACET_RS08525	COG3829	transcription factor binding
CACET_RS08530	COG3804	dihydrodipicolinate reductase
CACET_RS08540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CACET_RS08550	COG5012	cobalamin binding
CACET_RS08560	COG3457	Alanine racemase
CACET_RS08585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CACET_RS08610	COG2340	Cysteine-rich secretory protein family
CACET_RS08615	COG0438	transferase activity, transferring glycosyl groups
CACET_RS08630	COG1091	dTDP-4-dehydrorhamnose reductase activity
CACET_RS08655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CACET_RS08700	COG1959	2 iron, 2 sulfur cluster binding
CACET_RS08710	COG0822	iron-sulfur transferase activity
CACET_RS08715	COG0482	sulfurtransferase activity
CACET_RS08725	COG0628	permease
CACET_RS08730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CACET_RS08735	COG4472	Bacterial protein of unknown function (DUF965)
CACET_RS08745	COG0667	Aldo Keto reductase
CACET_RS08755	COG3906	Belongs to the UPF0473 family
CACET_RS08765	COG1489	DNA binding
CACET_RS08770	COG0735	belongs to the Fur family
CACET_RS08775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CACET_RS08790	COG3679	Belongs to the UPF0342 family
CACET_RS08810	COG0747	negative chemotaxis
CACET_RS08815	COG0601	transmembrane transport
CACET_RS08820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS08825	COG0444	Belongs to the ABC transporter superfamily
CACET_RS08830	COG1124	(ABC) transporter
CACET_RS08840	COG2197	response regulator
CACET_RS08845	COG4122	O-methyltransferase activity
CACET_RS08850	COG0826	peptidase U32
CACET_RS08855	COG0768	penicillin binding
CACET_RS08870	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CACET_RS08875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CACET_RS08880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CACET_RS08890	COG1459	type II secretion system
CACET_RS08960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CACET_RS08965	COG0006	proline dipeptidase activity
CACET_RS08970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CACET_RS08980	COG3854	ATPases associated with a variety of cellular activities
CACET_RS09020	COG1302	Protein conserved in bacteria
CACET_RS09025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CACET_RS09030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CACET_RS09035	COG1570	exodeoxyribonuclease VII activity
CACET_RS09040	COG1722	exodeoxyribonuclease VII activity
CACET_RS09050	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CACET_RS09060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CACET_RS09065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CACET_RS09070	COG1438	arginine binding
CACET_RS09075	COG0497	DNA recombination
CACET_RS09080	COG0750	zinc metalloprotease
CACET_RS09095	COG2137	regulation of response to DNA damage stimulus
CACET_RS09110	COG0463	Glycosyl transferase, family 2
CACET_RS09125	COG0494	nUDIX hydrolase
CACET_RS09130	COG1300	Membrane
CACET_RS09135	COG4974	Belongs to the 'phage' integrase family
CACET_RS09140	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CACET_RS09150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CACET_RS09160	COG1686	Belongs to the peptidase S11 family
CACET_RS09165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CACET_RS09165	COG0617	tRNA 3'-terminal CCA addition
CACET_RS09165	COG3620	sequence-specific DNA binding
CACET_RS09170	COG1994	Peptidase M50
CACET_RS09175	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CACET_RS09180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CACET_RS09185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CACET_RS09195	COG3874	Sporulation protein YtfJ
CACET_RS09205	COG1686	Belongs to the peptidase S11 family
CACET_RS09215	COG0445	tRNA wobble uridine modification
CACET_RS09225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CACET_RS09230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CACET_RS09245	COG1368	sulfuric ester hydrolase activity
CACET_RS09265	COG3681	Belongs to the UPF0597 family
CACET_RS09270	COG3829	transcription factor binding
CACET_RS09285	COG0187	DNA topoisomerase II activity
CACET_RS09290	COG4607	ABC-type enterochelin transport system periplasmic component
CACET_RS09295	COG4604	ABC transporter, ATP-binding protein
CACET_RS09300	COG4605	iron ion homeostasis
CACET_RS09305	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CACET_RS09310	COG1917	Cupin 2, conserved barrel domain protein
CACET_RS09310	COG4977	sequence-specific DNA binding
CACET_RS09315	COG0778	Nitroreductase
CACET_RS09320	COG0189	ligase activity
CACET_RS09335	COG3875	lactate racemase activity
CACET_RS09340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CACET_RS09365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CACET_RS09375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CACET_RS09380	COG0697	spore germination
CACET_RS09400	COG4974	Belongs to the 'phage' integrase family
CACET_RS09405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CACET_RS09410	COG0697	spore germination
CACET_RS09415	COG0531	amino acid
CACET_RS09425	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CACET_RS09440	COG1160	GTP binding
CACET_RS09445	COG0464	growth
CACET_RS09450	COG1923	regulation of RNA biosynthetic process
CACET_RS09455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CACET_RS09460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CACET_RS09465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CACET_RS09470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CACET_RS09475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CACET_RS09480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CACET_RS09490	COG0789	Transcriptional regulator
CACET_RS09510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CACET_RS09515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CACET_RS09515	COG0539	negative regulation of cytoplasmic translation
CACET_RS09520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CACET_RS09525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CACET_RS09530	COG0406	alpha-ribazole phosphatase activity
CACET_RS09545	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CACET_RS09560	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CACET_RS09570	COG1187	pseudouridine synthase activity
CACET_RS09575	COG0017	Asparaginyl-tRNA synthetase
CACET_RS09595	COG0613	PHP domain protein
CACET_RS09600	COG2359	stage V sporulation protein S
CACET_RS09605	COG1418	mRNA catabolic process
CACET_RS09615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CACET_RS09620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CACET_RS09625	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CACET_RS09630	COG1674	ftsk spoiiie
CACET_RS09635	COG0740	serine-type endopeptidase activity
CACET_RS09655	COG0612	Peptidase, M16
CACET_RS09665	COG1185	polyribonucleotide nucleotidyltransferase activity
CACET_RS09670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CACET_RS09675	COG0196	riboflavin kinase activity
CACET_RS09680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CACET_RS09690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CACET_RS09695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CACET_RS09705	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CACET_RS09710	COG0195	Participates in both transcription termination and antitermination
CACET_RS09715	COG0779	Required for maturation of 30S ribosomal subunits
CACET_RS09730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CACET_RS09735	COG0750	zinc metalloprotease
CACET_RS09740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CACET_RS09745	COG4589	Belongs to the CDS family
CACET_RS09750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CACET_RS09760	COG0233	cytoplasmic translational termination
CACET_RS09765	COG0528	UMP kinase activity
CACET_RS09770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CACET_RS09775	COG0052	Belongs to the universal ribosomal protein uS2 family
CACET_RS09800	COG1191	sigma factor activity
CACET_RS09805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CACET_RS09810	COG1776	CheC inhibitor of MCP methylation
CACET_RS09815	COG0835	chemotaxis
CACET_RS09820	COG2198	Histidine kinase
CACET_RS09820	COG0643	Histidine kinase
CACET_RS09825	COG2201	protein-glutamate methylesterase activity
CACET_RS09840	COG1419	protein localization to endoplasmic reticulum
CACET_RS09845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CACET_RS09850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CACET_RS09855	COG1684	flagellar biosynthetic protein fliR
CACET_RS09860	COG1987	bacterial-type flagellum assembly
CACET_RS09865	COG1338	Plays a role in the flagellum-specific transport system
CACET_RS09875	COG2201	protein-glutamate methylesterase activity
CACET_RS09880	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CACET_RS09880	COG1776	CheC inhibitor of MCP methylation
CACET_RS09885	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CACET_RS09895	COG1360	Flagellar Motor Protein
CACET_RS09920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CACET_RS09940	COG1157	protein secretion by the type III secretion system
CACET_RS09950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CACET_RS09955	COG1766	The M ring may be actively involved in energy transduction
CACET_RS09960	COG1677	Flagellar hook-basal body complex protein FliE
CACET_RS09965	COG1558	bacterial-type flagellum-dependent cell motility
CACET_RS09970	COG1815	bacterial-type flagellum-dependent cell motility
CACET_RS09980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CACET_RS09985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CACET_RS09990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CACET_RS09995	COG0758	DNA mediated transformation
CACET_RS10000	COG0606	chelatase, subunit chli
CACET_RS10005	COG0792	nuclease activity
CACET_RS10010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CACET_RS10020	COG0335	large ribosomal subunit rRNA binding
CACET_RS10025	COG0336	Belongs to the RNA methyltransferase TrmD family
CACET_RS10030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CACET_RS10035	COG1837	Belongs to the UPF0109 family
CACET_RS10040	COG0228	four-way junction DNA binding
CACET_RS10045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CACET_RS10050	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CACET_RS10055	COG0552	protein localization to endoplasmic reticulum
CACET_RS10060	COG1196	nuclear chromosome segregation
CACET_RS10070	COG0571	ribonuclease III activity
CACET_RS10075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CACET_RS10080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CACET_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
CACET_RS10090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CACET_RS10095	COG2070	2-Nitropropane dioxygenase
CACET_RS10100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CACET_RS10110	COG2030	dehydratase
CACET_RS10115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CACET_RS10120	COG1399	metal-binding, possibly nucleic acid-binding protein
CACET_RS10125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CACET_RS10130	COG1323	Belongs to the UPF0348 family
CACET_RS10135	COG3314	Sporulation integral membrane protein YlbJ
CACET_RS10145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CACET_RS10150	COG0742	ribosomal rna small subunit methyltransferase
CACET_RS10155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CACET_RS10160	COG1461	Dihydroxyacetone kinase
CACET_RS10165	COG1302	Protein conserved in bacteria
CACET_RS10170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CACET_RS10175	COG1564	THIamine pyrophosphokinase
CACET_RS10180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CACET_RS10185	COG1162	GTPase activity
CACET_RS10190	COG2815	serine threonine protein kinase
CACET_RS10190	COG0515	serine threonine protein kinase
CACET_RS10200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CACET_RS10205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CACET_RS10205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CACET_RS10210	COG2738	Putative neutral zinc metallopeptidase
CACET_RS10235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CACET_RS10240	COG0242	peptide deformylase activity
CACET_RS10245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CACET_RS10250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CACET_RS10255	COG1758	RNA polymerase activity
CACET_RS10260	COG0194	GDP metabolic process
CACET_RS10265	COG2052	Domain of unknown function (DUF370)
CACET_RS10270	COG1561	YicC-like family, N-terminal region
CACET_RS10275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CACET_RS10285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CACET_RS10290	COG0564	pseudouridine synthase activity
CACET_RS10295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CACET_RS10310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CACET_RS10315	COG3599	regulation of cell shape
CACET_RS10330	COG1799	cell septum assembly
CACET_RS10335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CACET_RS10360	COG2081	HI0933 family
CACET_RS10370	COG0840	transmembrane signaling receptor activity
CACET_RS10385	COG1968	undecaprenyl-diphosphatase activity
CACET_RS10390	COG5001	Diguanylate cyclase
CACET_RS10390	COG4251	negative regulation of phosphorylation
CACET_RS10390	COG3706	GGDEF domain
CACET_RS10390	COG2203	Gaf domain
CACET_RS10440	COG1484	DNA-dependent DNA replication
CACET_RS10470	COG1674	ftsk spoiiie
CACET_RS10470	COG0697	spore germination
CACET_RS10485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CACET_RS10500	COG0175	sulfate reduction
CACET_RS10510	COG1396	sequence-specific DNA binding
CACET_RS10530	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CACET_RS10535	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CACET_RS10540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CACET_RS10545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CACET_RS10550	COG1160	GTP binding
CACET_RS10590	COG5002	protein histidine kinase activity
CACET_RS10595	COG0745	RESPONSE REGULATOR receiver
CACET_RS10605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CACET_RS10610	COG1873	PFAM PRC-barrel domain
CACET_RS10615	COG1191	sigma factor activity
CACET_RS10620	COG1191	sigma factor activity
CACET_RS10635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CACET_RS10640	COG3856	small basic protein
CACET_RS10655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CACET_RS10660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CACET_RS10665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CACET_RS10670	COG0772	Belongs to the SEDS family
CACET_RS10675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CACET_RS10680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CACET_RS10685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CACET_RS10690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CACET_RS10695	COG0768	penicillin binding
CACET_RS10705	COG0275	rRNA processing
CACET_RS10710	COG2001	Belongs to the MraZ family
CACET_RS10715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CACET_RS10730	COG4869	propanediol catabolic process
CACET_RS10740	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CACET_RS10745	COG2096	Adenosyltransferase
CACET_RS10750	COG0494	nUDIX hydrolase
CACET_RS10760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CACET_RS10765	COG1333	cytochrome c biogenesis protein
CACET_RS10770	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CACET_RS10775	COG1231	oxidoreductase activity
CACET_RS10780	COG0352	thiamine-phosphate diphosphorylase activity
CACET_RS10790	COG0351	phosphomethylpyrimidine kinase
CACET_RS10795	COG3546	catalase activity
CACET_RS10820	COG1136	(ABC) transporter
CACET_RS10825	COG0577	efflux transmembrane transporter activity
CACET_RS10825	COG1136	(ABC) transporter
CACET_RS10845	COG1333	cytochrome c biogenesis protein
CACET_RS10850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CACET_RS10855	COG0693	protein deglycase activity
CACET_RS10855	COG0753	catalase activity
CACET_RS10860	COG0398	Pfam SNARE associated Golgi protein
CACET_RS10865	COG2200	EAL domain
CACET_RS10875	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CACET_RS10880	COG1518	maintenance of DNA repeat elements
CACET_RS10920	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CACET_RS10925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CACET_RS10930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CACET_RS10965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CACET_RS10970	COG5012	cobalamin binding
CACET_RS11000	COG0511	ligase activity, forming carbon-carbon bonds
CACET_RS11005	COG0439	Biotin carboxylase
CACET_RS11010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CACET_RS11015	COG0825	malonyl-CoA metabolic process
CACET_RS11030	COG5012	cobalamin binding
CACET_RS11065	COG5002	protein histidine kinase activity
CACET_RS11070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CACET_RS11075	COG0662	Cupin 2, conserved barrel domain protein
CACET_RS11085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CACET_RS11090	COG0746	molybdenum cofactor guanylyltransferase activity
CACET_RS11110	COG0640	Transcriptional regulator
CACET_RS11125	COG0328	RNA-DNA hybrid ribonuclease activity
CACET_RS11130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CACET_RS11145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CACET_RS11150	COG0358	DNA primase activity
CACET_RS11155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CACET_RS11170	COG1473	amidohydrolase
CACET_RS11185	COG2508	Transcriptional regulator
CACET_RS11195	COG0655	NAD(P)H dehydrogenase (quinone) activity
CACET_RS11230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CACET_RS11280	COG1595	DNA-templated transcription, initiation
CACET_RS11325	COG4584	PFAM Integrase catalytic
CACET_RS11325	COG2390	Transcriptional regulator
CACET_RS11330	COG1484	DNA-dependent DNA replication
CACET_RS11365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CACET_RS11370	COG0488	(ABC) transporter
CACET_RS11385	COG1695	Transcriptional regulator
CACET_RS11390	COG3976	FMN-binding domain protein
CACET_RS11390	COG1053	succinate dehydrogenase
CACET_RS11395	COG0745	RESPONSE REGULATOR receiver
CACET_RS11400	COG5002	protein histidine kinase activity
CACET_RS11405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CACET_RS11405	COG0574	Belongs to the PEP-utilizing enzyme family
CACET_RS11410	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CACET_RS11415	COG0517	IMP dehydrogenase activity
CACET_RS11420	COG0423	glycine-tRNA ligase activity
CACET_RS11425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CACET_RS11430	COG1381	Involved in DNA repair and RecF pathway recombination
CACET_RS11435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CACET_RS11440	COG0295	cytidine deaminase activity
CACET_RS11445	COG1470	cell adhesion involved in biofilm formation
CACET_RS11455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CACET_RS11460	COG1480	7TM receptor with intracellular HD hydrolase
CACET_RS11465	COG1702	phosphate starvation-inducible protein PhoH
CACET_RS11485	COG4864	UPF0365 protein
CACET_RS11490	COG1030	water channel activity
CACET_RS11500	COG1610	YqeY-like protein
CACET_RS11505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CACET_RS11510	COG0537	adenosine 5'-monophosphoramidase activity
CACET_RS11515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CACET_RS11520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CACET_RS11525	COG2264	protein methyltransferase activity
CACET_RS11530	COG0484	heat shock protein binding
CACET_RS11535	COG0443	Heat shock 70 kDa protein
CACET_RS11540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CACET_RS11545	COG1420	regulation of RNA biosynthetic process
CACET_RS11550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CACET_RS11555	COG0481	GTPase activity
CACET_RS11575	COG0268	Binds directly to 16S ribosomal RNA
CACET_RS11580	COG1466	dna polymerase III delta subunit
CACET_RS11585	COG2333	competence protein COMEC
CACET_RS11585	COG0658	competence protein
CACET_RS11625	COG1136	(ABC) transporter
CACET_RS11625	COG0577	efflux transmembrane transporter activity
CACET_RS11680	COG3290	protein histidine kinase activity
CACET_RS11695	COG1234	tRNA 3'-trailer cleavage
CACET_RS11715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CACET_RS11720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CACET_RS11725	COG0513	Belongs to the DEAD box helicase family
CACET_RS11735	COG0814	amino acid
CACET_RS11740	COG0697	spore germination
CACET_RS11755	COG0733	neurotransmitter:sodium symporter activity
CACET_RS11760	COG1136	(ABC) transporter
CACET_RS11760	COG0577	efflux transmembrane transporter activity
CACET_RS11770	COG1136	(ABC) transporter
CACET_RS11775	COG0778	Nitroreductase
CACET_RS11805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CACET_RS11810	COG0154	amidase activity
CACET_RS11815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CACET_RS11820	COG0017	Asparaginyl-tRNA synthetase
CACET_RS11830	COG0440	acetolactate synthase activity
CACET_RS11835	COG0028	Belongs to the TPP enzyme family
CACET_RS11855	COG0747	negative chemotaxis
CACET_RS11860	COG0747	negative chemotaxis
CACET_RS11865	COG4608	Belongs to the ABC transporter superfamily
CACET_RS11870	COG0444	Belongs to the ABC transporter superfamily
CACET_RS11875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS11890	COG1063	alcohol dehydrogenase
CACET_RS11895	COG2610	gluconate transmembrane transporter activity
CACET_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
CACET_RS11925	COG1132	(ABC) transporter
CACET_RS11930	COG1132	(ABC) transporter
CACET_RS11935	COG4608	Belongs to the ABC transporter superfamily
CACET_RS11940	COG0444	Belongs to the ABC transporter superfamily
CACET_RS11945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS11955	COG4166	transmembrane transport
CACET_RS11965	COG2310	stress, protein
CACET_RS11970	COG2310	stress, protein
CACET_RS11980	COG3853	Toxic anion resistance protein (TelA)
CACET_RS11990	COG1115	amino acid carrier protein
CACET_RS11995	COG2204	response regulator
CACET_RS12020	COG3842	ATPase activity
CACET_RS12025	COG0395	ABC-type sugar transport system, permease component
CACET_RS12030	COG1175	transmembrane transport
CACET_RS12055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CACET_RS12065	COG0626	cystathionine gamma-synthase activity
CACET_RS12070	COG0626	cystathionine gamma-synthase activity
CACET_RS12080	COG1070	Carbohydrate kinase
CACET_RS12085	COG1063	alcohol dehydrogenase
CACET_RS12100	COG1129	ABC transporter
CACET_RS12105	COG2207	Transcriptional regulator
CACET_RS12105	COG4753	response regulator
CACET_RS12110	COG2972	Histidine kinase
CACET_RS12120	COG1131	(ABC) transporter
CACET_RS12125	COG3559	Exporter of polyketide antibiotics
CACET_RS12130	COG0322	excinuclease ABC activity
CACET_RS12150	COG1595	DNA-templated transcription, initiation
CACET_RS12155	COG1408	metallophosphoesterase
CACET_RS12165	COG0281	malic enzyme
CACET_RS12170	COG4565	transcriptional regulatory protein
CACET_RS12175	COG3290	protein histidine kinase activity
CACET_RS12180	COG0431	NADPH-dependent FMN reductase
CACET_RS12180	COG3976	FMN-binding domain protein
CACET_RS12180	COG1053	succinate dehydrogenase
CACET_RS12185	COG0840	transmembrane signaling receptor activity
CACET_RS12195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CACET_RS12225	COG5002	protein histidine kinase activity
CACET_RS12230	COG0745	RESPONSE REGULATOR receiver
CACET_RS12240	COG1316	TRANSCRIPTIONal
CACET_RS12250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CACET_RS12255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CACET_RS12265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CACET_RS12280	COG3314	Sporulation integral membrane protein YlbJ
CACET_RS12290	COG2211	Major facilitator Superfamily
CACET_RS12295	COG5012	cobalamin binding
CACET_RS12310	COG1278	Cold shock
CACET_RS12315	COG2197	response regulator
CACET_RS12320	COG4585	Histidine kinase
CACET_RS12335	COG1131	(ABC) transporter
CACET_RS12345	COG1695	Transcriptional regulator
CACET_RS12355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CACET_RS12365	COG0398	Pfam SNARE associated Golgi protein
CACET_RS12385	COG5609	conserved protein (DUF2294)
CACET_RS12390	COG2223	nitrite transmembrane transporter activity
CACET_RS12400	COG0674	pyruvate-flavodoxin oxidoreductase activity
CACET_RS12430	COG0714	Associated with various cellular activities
CACET_RS12435	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CACET_RS12445	COG4120	Belongs to the binding-protein-dependent transport system permease family
CACET_RS12450	COG1116	anion transmembrane transporter activity
CACET_RS12460	COG1876	peptidase activity
CACET_RS12480	COG3858	chitin binding
CACET_RS12480	COG1388	LysM domain
CACET_RS12490	COG0534	Mate efflux family protein
CACET_RS12510	COG4555	ABC transporter
CACET_RS12525	COG3069	C4-dicarboxylate transmembrane transporter activity
CACET_RS12535	COG1649	PFAM Uncharacterised BCR, COG1649
CACET_RS12545	COG0697	spore germination
CACET_RS12575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CACET_RS12580	COG5002	protein histidine kinase activity
CACET_RS12595	COG2364	Membrane
CACET_RS12605	COG1032	radical SAM domain protein
CACET_RS12615	COG1695	Transcriptional regulator
CACET_RS12630	COG1120	ATPase activity
CACET_RS12635	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CACET_RS12640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CACET_RS12695	COG2378	regulation of single-species biofilm formation
CACET_RS12705	COG0310	cobalt ion transport
CACET_RS12715	COG1122	ATPase activity
CACET_RS12775	COG1151	hydroxylamine reductase activity
CACET_RS12780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CACET_RS12785	COG1357	PFAM Pentapeptide repeats (8 copies)
CACET_RS12800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CACET_RS12820	COG0789	Transcriptional regulator
CACET_RS12845	COG0789	Transcriptional regulator
CACET_RS12850	COG3173	Aminoglycoside phosphotransferase
CACET_RS12905	COG0596	Alpha beta hydrolase
CACET_RS12920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CACET_RS12930	COG0840	transmembrane signaling receptor activity
CACET_RS12930	COG5278	phosphoserine phosphatase activity
CACET_RS12935	COG0706	membrane insertase activity
CACET_RS12940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CACET_RS12960	COG0577	efflux transmembrane transporter activity
CACET_RS12965	COG1136	(ABC) transporter
CACET_RS12970	COG0642	Histidine kinase
CACET_RS12975	COG0745	RESPONSE REGULATOR receiver
CACET_RS12985	COG0789	Transcriptional regulator
CACET_RS13030	COG1131	(ABC) transporter
CACET_RS13040	COG3173	Aminoglycoside phosphotransferase
CACET_RS13050	COG1309	transcriptional regulator
CACET_RS13070	COG1476	TRANSCRIPTIONal
CACET_RS13090	COG5002	protein histidine kinase activity
CACET_RS13090	COG3850	Histidine kinase
CACET_RS13215	COG4974	Belongs to the 'phage' integrase family
CACET_RS13290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CACET_RS13295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CACET_RS13340	COG1196	nuclear chromosome segregation
CACET_RS13345	COG4895	conserved protein (DUF2196)
CACET_RS13505	COG1459	type II secretion system
CACET_RS13545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CACET_RS13555	COG2165	general secretion pathway protein
CACET_RS13595	COG1660	Displays ATPase and GTPase activities
CACET_RS13680	COG2226	methyltransferase
CACET_RS13690	COG1183	phosphatidylcholine synthase activity
CACET_RS13695	COG0191	fructose-bisphosphate aldolase activity
CACET_RS13705	COG2357	RelA SpoT domain protein
CACET_RS13715	COG1242	4 iron, 4 sulfur cluster binding
CACET_RS13730	COG3875	lactate racemase activity
CACET_RS13735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CACET_RS13750	COG2056	Na+-H+ antiporter family
CACET_RS13755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CACET_RS13760	COG0281	malic enzyme
CACET_RS13785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CACET_RS13800	COG2719	SpoVR family
CACET_RS13805	COG2718	Belongs to the UPF0229 family
CACET_RS13810	COG2766	serine protein kinase
CACET_RS13815	COG0840	transmembrane signaling receptor activity
CACET_RS13820	COG0835	chemotaxis
CACET_RS13830	COG2996	Protein conserved in bacteria
CACET_RS13850	COG1132	(ABC) transporter
CACET_RS13860	COG0745	RESPONSE REGULATOR receiver
CACET_RS13865	COG5002	protein histidine kinase activity
CACET_RS13885	COG3850	Histidine kinase
CACET_RS13885	COG2205	protein histidine kinase activity
CACET_RS13885	COG4999	Histidine kinase
CACET_RS13885	COG3437	response regulator, receiver
CACET_RS13895	COG1982	Orn Lys Arg decarboxylase major
CACET_RS13920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CACET_RS13925	COG0577	efflux transmembrane transporter activity
CACET_RS13930	COG1136	(ABC) transporter
CACET_RS13940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CACET_RS13955	COG1396	sequence-specific DNA binding
CACET_RS13960	COG0534	Mate efflux family protein
CACET_RS13965	COG3300	MHYT domain
CACET_RS13965	COG5001	Diguanylate cyclase
CACET_RS13975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CACET_RS13980	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CACET_RS13995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CACET_RS13995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CACET_RS14000	COG1132	(ABC) transporter
CACET_RS14005	COG1132	(ABC) transporter
CACET_RS14010	COG2226	methyltransferase
CACET_RS14010	COG1073	alpha beta
CACET_RS14025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS14030	COG0601	transmembrane transport
CACET_RS14035	COG0747	negative chemotaxis
CACET_RS14040	COG2226	methyltransferase
CACET_RS14050	COG0747	negative chemotaxis
CACET_RS14055	COG4608	Belongs to the ABC transporter superfamily
CACET_RS14060	COG0444	Belongs to the ABC transporter superfamily
CACET_RS14065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS14070	COG0601	transmembrane transport
CACET_RS14075	COG4608	Belongs to the ABC transporter superfamily
CACET_RS14080	COG0444	Belongs to the ABC transporter superfamily
CACET_RS14090	COG0601	transmembrane transport
CACET_RS14095	COG0747	negative chemotaxis
CACET_RS14110	COG4608	Belongs to the ABC transporter superfamily
CACET_RS14115	COG0444	Belongs to the ABC transporter superfamily
CACET_RS14120	COG0747	negative chemotaxis
CACET_RS14125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS14130	COG0601	transmembrane transport
CACET_RS14135	COG2379	hydroxypyruvate reductase
CACET_RS14155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CACET_RS14160	COG1459	type II secretion system
CACET_RS14165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CACET_RS14230	COG1132	(ABC) transporter
CACET_RS14235	COG1132	(ABC) transporter
CACET_RS14240	COG2207	Transcriptional regulator
CACET_RS14245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CACET_RS14255	COG0720	synthase
CACET_RS14275	COG0697	spore germination
CACET_RS14290	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CACET_RS14305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CACET_RS14310	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CACET_RS14315	COG1120	ATPase activity
CACET_RS14320	COG1131	(ABC) transporter
CACET_RS14345	COG1924	4 iron, 4 sulfur cluster binding
CACET_RS14380	COG2217	Heavy metal translocating P-type atpase
CACET_RS14410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CACET_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
CACET_RS14435	COG1393	Belongs to the ArsC family
CACET_RS14450	COG2414	aldehyde ferredoxin oxidoreductase
CACET_RS14455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CACET_RS14465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CACET_RS14465	COG2111	Na H antiporter
CACET_RS14470	COG1006	Multisubunit Na H antiporter MnhC subunit
CACET_RS14505	COG0584	glycerophosphoryl diester phosphodiesterase
CACET_RS14515	COG0395	ABC-type sugar transport system, permease component
CACET_RS14520	COG1175	transmembrane transport
CACET_RS14550	COG0534	Mate efflux family protein
CACET_RS14560	COG1131	(ABC) transporter
CACET_RS14565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CACET_RS14575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CACET_RS14585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CACET_RS14610	COG1454	alcohol dehydrogenase
CACET_RS14615	COG2508	Transcriptional regulator
CACET_RS14620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CACET_RS14635	COG1199	ATP-dependent helicase activity
CACET_RS14650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CACET_RS14665	COG4869	propanediol catabolic process
CACET_RS14670	COG1454	alcohol dehydrogenase
CACET_RS14670	COG1012	belongs to the aldehyde dehydrogenase family
CACET_RS14690	COG4656	Part of a membrane complex involved in electron transport
CACET_RS14715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CACET_RS14720	COG1882	Formate acetyltransferase
CACET_RS14750	COG1454	alcohol dehydrogenase
CACET_RS14755	COG3275	phosphorelay sensor kinase activity
CACET_RS14785	COG0531	amino acid
CACET_RS14790	COG0697	spore germination
CACET_RS14800	COG4948	Mandelate Racemase Muconate Lactonizing
CACET_RS14815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CACET_RS14835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CACET_RS14855	COG0789	Transcriptional regulator
CACET_RS14860	COG1408	metallophosphoesterase
CACET_RS14865	COG3620	sequence-specific DNA binding
CACET_RS14870	COG2207	Transcriptional regulator
CACET_RS14870	COG3708	Transcriptional regulator
CACET_RS14875	COG1162	GTPase activity
CACET_RS14890	COG1131	(ABC) transporter
CACET_RS14900	COG1595	DNA-templated transcription, initiation
CACET_RS14910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CACET_RS14915	COG1686	Belongs to the peptidase S11 family
CACET_RS14920	COG0288	reversible hydration of carbon dioxide
CACET_RS14925	COG3246	L-lysine catabolic process to acetate
CACET_RS14930	COG2186	Transcriptional regulator
CACET_RS14935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS14935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CACET_RS14945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CACET_RS14980	COG1132	(ABC) transporter
CACET_RS14985	COG1132	(ABC) transporter
CACET_RS15000	COG1272	protein, Hemolysin III
CACET_RS15020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CACET_RS15030	COG3022	response to hydroperoxide
CACET_RS15040	COG0840	transmembrane signaling receptor activity
CACET_RS15055	COG2239	Acts as a magnesium transporter
CACET_RS15065	COG2217	Heavy metal translocating P-type atpase
CACET_RS15070	COG0640	Transcriptional regulator
CACET_RS15085	COG2197	response regulator
CACET_RS15095	COG1131	(ABC) transporter
CACET_RS15110	COG3173	Aminoglycoside phosphotransferase
CACET_RS15135	COG1757	Na H antiporter
CACET_RS15145	COG0444	Belongs to the ABC transporter superfamily
CACET_RS15150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS15155	COG0601	transmembrane transport
CACET_RS15170	COG5002	protein histidine kinase activity
CACET_RS15170	COG0642	Histidine kinase
CACET_RS15175	COG1120	ATPase activity
CACET_RS15180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CACET_RS15210	COG2226	methyltransferase
CACET_RS15225	COG0390	transport system, permease component
CACET_RS15250	COG1116	anion transmembrane transporter activity
CACET_RS15260	COG1131	(ABC) transporter
CACET_RS15270	COG1073	alpha beta
CACET_RS15270	COG2226	methyltransferase
CACET_RS15275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CACET_RS15280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CACET_RS15295	COG0745	RESPONSE REGULATOR receiver
CACET_RS15300	COG2205	protein histidine kinase activity
CACET_RS15305	COG1136	(ABC) transporter
CACET_RS15310	COG0577	efflux transmembrane transporter activity
CACET_RS15325	COG1131	(ABC) transporter
CACET_RS15350	COG5002	protein histidine kinase activity
CACET_RS15355	COG0745	RESPONSE REGULATOR receiver
CACET_RS15360	COG0577	efflux transmembrane transporter activity
CACET_RS15365	COG1136	(ABC) transporter
CACET_RS15410	COG4824	toxin secretion phage lysis holin
CACET_RS15530	COG0740	serine-type endopeptidase activity
CACET_RS15565	COG1191	sigma factor activity
CACET_RS15630	COG2002	toxin-antitoxin pair type II binding
CACET_RS15695	COG4974	Belongs to the 'phage' integrase family
CACET_RS15710	COG3030	protein affecting phage T7 exclusion by the F plasmid
CACET_RS15715	COG0824	Thioesterase
CACET_RS15750	COG0205	6-phosphofructokinase activity
CACET_RS15760	COG0587	DNA-directed DNA polymerase activity
CACET_RS15780	COG0477	Major facilitator Superfamily
CACET_RS15790	COG2188	Transcriptional regulator
CACET_RS15795	COG5012	cobalamin binding
CACET_RS15800	COG5012	cobalamin binding
CACET_RS15810	COG5012	cobalamin binding
CACET_RS15820	COG5012	cobalamin binding
CACET_RS15835	COG3404	Formiminotransferase-cyclodeaminase
CACET_RS15860	COG1481	regulation of sporulation
CACET_RS15870	COG3033	Beta-eliminating lyase
CACET_RS15875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CACET_RS15880	COG1660	Displays ATPase and GTPase activities
CACET_RS15885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CACET_RS15900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CACET_RS15915	COG3383	formate dehydrogenase (NAD+) activity
CACET_RS15950	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CACET_RS15955	COG0322	excinuclease ABC activity
CACET_RS15965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CACET_RS15970	COG0556	nucleotide-excision repair
CACET_RS15975	COG0793	Belongs to the peptidase S41A family
CACET_RS15975	COG3409	Peptidoglycan-binding domain 1 protein
CACET_RS15980	COG0739	heme binding
CACET_RS15985	COG2177	Part of the ABC transporter FtsEX involved in
CACET_RS15990	COG2884	Cell division ATP-binding protein ftsE
CACET_RS15995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CACET_RS16000	COG2204	response regulator
CACET_RS16005	COG3852	Histidine kinase
CACET_RS16010	COG2217	Heavy metal translocating P-type atpase
CACET_RS16065	COG0411	ABC transporter
CACET_RS16085	COG1067	ATP-dependent peptidase activity
CACET_RS16090	COG1388	LysM domain
CACET_RS16090	COG1705	Flagellar rod assembly protein muramidase FlgJ
CACET_RS16095	COG3448	diguanylate cyclase activity
CACET_RS16095	COG4175	Glycine betaine
CACET_RS16120	COG3958	Transketolase
CACET_RS16125	COG3959	Transketolase, thiamine diphosphate binding domain
CACET_RS16130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CACET_RS16155	COG2337	Toxic component of a toxin-antitoxin (TA) module
CACET_RS16175	COG0736	holo-[acyl-carrier-protein] synthase activity
CACET_RS16190	COG0651	ATP synthesis coupled electron transport
CACET_RS16195	COG0651	ATP synthesis coupled electron transport
CACET_RS16200	COG0651	ATP synthesis coupled electron transport
CACET_RS16210	COG2111	Na H antiporter
CACET_RS16225	COG1320	monovalent cation:proton antiporter activity
CACET_RS16230	COG2212	antiporter activity
CACET_RS16235	COG1863	multisubunit Na H antiporter MnhE subunit
CACET_RS16250	COG0517	IMP dehydrogenase activity
CACET_RS16250	COG0516	GMP reductase activity
CACET_RS16255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CACET_RS16260	COG1074	ATP-dependent DNA helicase activity
CACET_RS16265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CACET_RS16280	COG1592	Rubrerythrin
CACET_RS16285	COG0688	phosphatidylethanolamine metabolic process
CACET_RS16290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CACET_RS16295	COG0167	dihydroorotate dehydrogenase activity
CACET_RS16300	COG0543	2 iron, 2 sulfur cluster binding
CACET_RS16315	COG0284	orotidine-5'-phosphate decarboxylase activity
CACET_RS16320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CACET_RS16330	COG0473	3-isopropylmalate dehydrogenase activity
CACET_RS16335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CACET_RS16350	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CACET_RS16355	COG2081	HI0933 family
CACET_RS16360	COG1522	sequence-specific DNA binding
CACET_RS16365	COG1522	sequence-specific DNA binding
CACET_RS16370	COG0535	radical SAM domain protein
CACET_RS16375	COG0535	radical SAM domain protein
CACET_RS16390	COG0726	polysaccharide deacetylase
CACET_RS16395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CACET_RS16400	COG0784	Response regulator, receiver
CACET_RS16400	COG2205	protein histidine kinase activity
CACET_RS16400	COG5002	protein histidine kinase activity
CACET_RS16405	COG5002	protein histidine kinase activity
CACET_RS16415	COG3290	protein histidine kinase activity
CACET_RS16425	COG1053	succinate dehydrogenase
CACET_RS16430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CACET_RS16440	COG1592	Rubrerythrin
CACET_RS16445	COG3103	Sh3 type 3 domain protein
CACET_RS16445	COG0366	Alpha amylase catalytic
CACET_RS16450	COG0058	SHG alpha-glucan phosphorylase activity
CACET_RS16455	COG0297	glycogen (starch) synthase activity
CACET_RS16460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CACET_RS16465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CACET_RS16470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CACET_RS16480	COG0697	spore germination
CACET_RS16495	COG0531	amino acid
CACET_RS16505	COG1595	DNA-templated transcription, initiation
CACET_RS16545	COG3829	transcription factor binding
CACET_RS16560	COG1194	a g-specific adenine glycosylase
CACET_RS16565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CACET_RS16575	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CACET_RS16585	COG2755	lipolytic protein G-D-S-L family
CACET_RS16590	COG1191	sigma factor activity
CACET_RS16620	COG0475	glutathione-regulated potassium exporter activity
CACET_RS16645	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CACET_RS16655	COG4608	Belongs to the ABC transporter superfamily
CACET_RS16660	COG0444	Belongs to the ABC transporter superfamily
CACET_RS16665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CACET_RS16670	COG0601	transmembrane transport
CACET_RS16675	COG0747	negative chemotaxis
CACET_RS16690	COG4191	Histidine kinase
CACET_RS16695	COG0784	Response regulator, receiver
CACET_RS16700	COG0786	glutamate:sodium symporter activity
CACET_RS16715	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CACET_RS16720	COG3051	citrate lyase alpha subunit
CACET_RS16730	COG3052	prosthetic group binding
CACET_RS16770	COG5012	cobalamin binding
CACET_RS16775	COG5598	trimethylamine methyltransferase
CACET_RS16780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CACET_RS16785	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
CACET_RS16790	COG5012	cobalamin binding
CACET_RS16800	COG0745	RESPONSE REGULATOR receiver
CACET_RS16810	COG2201	protein-glutamate methylesterase activity
CACET_RS16820	COG0840	transmembrane signaling receptor activity
CACET_RS16825	COG0835	chemotaxis
CACET_RS16830	COG2198	Histidine kinase
CACET_RS16830	COG0643	Histidine kinase
CACET_RS16840	COG3118	belongs to the thioredoxin family
CACET_RS16850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CACET_RS16875	COG0840	transmembrane signaling receptor activity
CACET_RS16890	COG1079	Belongs to the binding-protein-dependent transport system permease family
CACET_RS16895	COG4603	Belongs to the binding-protein-dependent transport system permease family
CACET_RS16900	COG3845	ABC transporter
CACET_RS16910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CACET_RS16915	COG0436	Aminotransferase
CACET_RS16920	COG0463	Glycosyl transferase, family 2
CACET_RS16920	COG0457	Tetratricopeptide repeat
CACET_RS16930	COG5001	Diguanylate cyclase
CACET_RS16935	COG3275	phosphorelay sensor kinase activity
CACET_RS16940	COG3279	Response regulator of the LytR AlgR family
CACET_RS16945	COG1966	Carbon starvation protein
CACET_RS16955	COG0589	response to stress
CACET_RS16965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CACET_RS16970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CACET_RS16975	COG1966	Carbon starvation protein
CACET_RS16995	COG0674	pyruvate-flavodoxin oxidoreductase activity
CACET_RS17010	COG3426	butyrate kinase activity
CACET_RS17015	COG0280	phosphate acetyltransferase
CACET_RS17020	COG3426	butyrate kinase activity
CACET_RS17025	COG3829	transcription factor binding
CACET_RS17025	COG3290	protein histidine kinase activity
CACET_RS17035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CACET_RS17045	COG0137	argininosuccinate synthase activity
CACET_RS17050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CACET_RS17050	COG5322	oxidoreductase activity
CACET_RS17130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CACET_RS17135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CACET_RS17135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CACET_RS17150	COG1971	Probably functions as a manganese efflux pump
CACET_RS17185	COG0640	Transcriptional regulator
CACET_RS17195	COG0426	domain, Protein
CACET_RS17210	COG2323	membrane
CACET_RS17220	COG1473	amidohydrolase
CACET_RS17225	COG1619	proteins homologs of microcin C7 resistance protein MccF
CACET_RS17230	COG0700	Nucleoside recognition
CACET_RS17235	COG2715	membrane protein required for spore maturation
CACET_RS17240	COG0019	diaminopimelate decarboxylase activity
CACET_RS17245	COG1968	undecaprenyl-diphosphatase activity
CACET_RS17250	COG0367	asparagine synthase
CACET_RS17255	COG1376	ErfK ybiS ycfS ynhG family protein
CACET_RS17300	COG0110	maltose O-acetyltransferase activity
CACET_RS17315	COG0110	maltose O-acetyltransferase activity
CACET_RS17365	COG0484	heat shock protein binding
CACET_RS17370	COG0798	PFAM Bile acid sodium symporter
CACET_RS17380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CACET_RS17410	COG1376	ErfK ybiS ycfS ynhG family protein
CACET_RS17425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CACET_RS17430	COG1151	hydroxylamine reductase activity
CACET_RS17435	COG2861	carbohydrate metabolic process
CACET_RS17445	COG0860	N-Acetylmuramoyl-L-alanine amidase
CACET_RS17455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CACET_RS17460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CACET_RS17470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CACET_RS17480	COG1122	ATPase activity
CACET_RS17485	COG0203	ribosomal protein L17
CACET_RS17490	COG0202	RNA polymerase activity
CACET_RS17495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CACET_RS17500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CACET_RS17505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CACET_RS17510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CACET_RS17515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CACET_RS17530	COG0563	adenylate kinase activity
CACET_RS17535	COG0201	protein transport
CACET_RS17540	COG0200	Binds to the 23S rRNA
CACET_RS17545	COG1841	ribosomal large subunit assembly
CACET_RS17550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CACET_RS17555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CACET_RS17560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CACET_RS17565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CACET_RS17570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CACET_RS17575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CACET_RS17580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CACET_RS17585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CACET_RS17590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CACET_RS17595	COG0255	Belongs to the universal ribosomal protein uL29 family
CACET_RS17600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CACET_RS17605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CACET_RS17610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CACET_RS17615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CACET_RS17620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CACET_RS17625	COG0089	rRNA binding
CACET_RS17630	COG0088	Forms part of the polypeptide exit tunnel
CACET_RS17635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CACET_RS17640	COG0051	transcription antitermination factor activity, RNA binding
CACET_RS17645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CACET_RS17650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CACET_RS17655	COG0049	tRNA binding
CACET_RS17660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CACET_RS17665	COG1358	cellular component organization or biogenesis
CACET_RS17670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CACET_RS17675	COG0085	RNA polymerase activity
CACET_RS17680	COG0222	ribosome binding
CACET_RS17685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CACET_RS17690	COG0081	regulation of translation
CACET_RS17695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CACET_RS17700	COG0250	Participates in transcription elongation, termination and antitermination
CACET_RS17710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CACET_RS17715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CACET_RS17725	COG3688	RNA-binding protein containing a PIN domain
CACET_RS17730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CACET_RS17745	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CACET_RS17750	COG0215	cysteine-tRNA ligase activity
CACET_RS17755	COG1045	serine acetyltransferase
CACET_RS17760	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CACET_RS17760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CACET_RS17765	COG4086	secreted protein
CACET_RS17770	COG0442	prolyl-tRNA aminoacylation
CACET_RS17775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CACET_RS17780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CACET_RS17785	COG4956	integral membrane protein (PIN domain superfamily)
CACET_RS17790	COG1329	Transcriptional regulator
CACET_RS17800	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CACET_RS17805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CACET_RS17810	COG0542	response to heat
CACET_RS17815	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CACET_RS17820	COG3880	PFAM UvrB UvrC protein
CACET_RS17830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CACET_RS17835	COG2032	superoxide dismutase activity
CACET_RS17845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CACET_RS17875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CACET_RS17885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CACET_RS17890	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CACET_RS17895	COG4684	Psort location CytoplasmicMembrane, score
CACET_RS17900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CACET_RS17900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CACET_RS17905	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CACET_RS17910	COG0511	ligase activity, forming carbon-carbon bonds
CACET_RS17910	COG5016	pyruvate
CACET_RS17920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CACET_RS17925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CACET_RS17930	COG0037	tRNA processing
CACET_RS17940	COG2304	oxidoreductase activity
CACET_RS17950	COG0116	Belongs to the methyltransferase superfamily
CACET_RS17975	COG0697	spore germination
CACET_RS17990	COG3191	aminopeptidase activity
CACET_RS18005	COG1181	Belongs to the D-alanine--D-alanine ligase family
CACET_RS18025	COG0531	amino acid
CACET_RS18030	COG0531	amino acid
CACET_RS18040	COG0697	spore germination
CACET_RS18060	COG1802	Transcriptional regulator
CACET_RS18065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CACET_RS18080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CACET_RS18085	COG4466	Protein conserved in bacteria
CACET_RS18090	COG2385	sporulation resulting in formation of a cellular spore
CACET_RS18095	COG1846	Transcriptional regulator
CACET_RS18105	COG1757	Na H antiporter
CACET_RS18110	COG3976	FMN-binding domain protein
CACET_RS18110	COG1053	succinate dehydrogenase
CACET_RS18115	COG0704	Plays a role in the regulation of phosphate uptake
CACET_RS18120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CACET_RS18125	COG0581	inorganic phosphate transmembrane transporter activity
CACET_RS18130	COG0573	inorganic phosphate transmembrane transporter activity
CACET_RS18135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CACET_RS18140	COG0840	transmembrane signaling receptor activity
CACET_RS18170	COG1533	DNA photolyase activity
CACET_RS18180	COG2323	membrane
CACET_RS18200	COG0083	homoserine kinase activity
CACET_RS18210	COG0460	homoserine dehydrogenase
CACET_RS18215	COG4492	Belongs to the UPF0735 family
CACET_RS18220	COG0733	neurotransmitter:sodium symporter activity
CACET_RS18245	COG0243	molybdopterin cofactor binding
CACET_RS18250	COG0277	FAD linked oxidase domain protein
CACET_RS18260	COG2086	electron transfer activity
CACET_RS18265	COG1346	cytolysis
CACET_RS18275	COG2186	Transcriptional regulator
CACET_RS18285	COG0165	Argininosuccinate lyase
CACET_RS18290	COG2033	superoxide reductase activity
CACET_RS18305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CACET_RS18305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CACET_RS18305	COG1013	pyruvate-flavodoxin oxidoreductase activity
CACET_RS18305	COG0674	pyruvate-flavodoxin oxidoreductase activity
CACET_RS18315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CACET_RS18320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CACET_RS18325	COG2873	o-acetylhomoserine
CACET_RS18330	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CACET_RS18350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CACET_RS18355	COG0723	plastoquinol--plastocyanin reductase activity
CACET_RS18355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CACET_RS18365	COG0352	thiamine-phosphate diphosphorylase activity
CACET_RS18370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CACET_RS18375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CACET_RS18380	COG2022	thiamine diphosphate biosynthetic process
CACET_RS18395	COG3830	Belongs to the UPF0237 family
CACET_RS18400	COG2848	UPF0210 protein
CACET_RS18405	COG0542	response to heat
CACET_RS18410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CACET_RS18415	COG2340	Cysteine-rich secretory protein family
CACET_RS18425	COG0463	Glycosyl transferase, family 2
CACET_RS18435	COG3437	response regulator, receiver
CACET_RS18445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CACET_RS18450	COG2205	protein histidine kinase activity
CACET_RS18450	COG0784	Response regulator, receiver
CACET_RS18450	COG5002	protein histidine kinase activity
CACET_RS18455	COG0488	(ABC) transporter
CACET_RS18460	COG2252	PERMEase
CACET_RS18470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CACET_RS18475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CACET_RS18480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CACET_RS18480	COG2199	diguanylate cyclase activity
CACET_RS18505	COG3426	butyrate kinase activity
CACET_RS18510	COG0583	DNA-binding transcription factor activity
CACET_RS18515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CACET_RS18525	COG2414	aldehyde ferredoxin oxidoreductase
CACET_RS18530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CACET_RS18535	COG1473	amidohydrolase
CACET_RS18540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CACET_RS18545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CACET_RS18550	COG0006	proline dipeptidase activity
CACET_RS18570	COG1122	ATPase activity
CACET_RS18580	COG1694	Mazg nucleotide pyrophosphohydrolase
CACET_RS18595	COG1116	anion transmembrane transporter activity
CACET_RS18610	COG0129	dihydroxy-acid dehydratase activity
CACET_RS18615	COG2223	nitrite transmembrane transporter activity
CACET_RS18620	COG0708	Exodeoxyribonuclease III
CACET_RS18635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CACET_RS18640	COG1187	pseudouridine synthase activity
CACET_RS18645	COG0326	Molecular chaperone. Has ATPase activity
CACET_RS18655	COG5002	protein histidine kinase activity
CACET_RS18665	COG2962	Rard protein
CACET_RS18670	COG2226	methyltransferase
CACET_RS18670	COG1073	alpha beta
CACET_RS18680	COG1595	DNA-templated transcription, initiation
CACET_RS18695	COG0840	transmembrane signaling receptor activity
CACET_RS18710	COG2721	sulfolactate sulfo-lyase activity
CACET_RS18715	COG2721	sulfolactate sulfo-lyase activity
CACET_RS18720	COG3290	protein histidine kinase activity
CACET_RS18720	COG3829	transcription factor binding
CACET_RS18725	COG0534	Mate efflux family protein
CACET_RS18735	COG0733	neurotransmitter:sodium symporter activity
CACET_RS18745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CACET_RS18750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CACET_RS18755	COG3842	ATPase activity
CACET_RS18760	COG1177	transmembrane transport
CACET_RS18780	COG2986	histidine ammonia-lyase
CACET_RS18785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CACET_RS18805	COG2986	histidine ammonia-lyase
CACET_RS18820	COG3829	transcription factor binding
CACET_RS18835	COG2508	Transcriptional regulator
CACET_RS18840	COG1757	Na H antiporter
CACET_RS18850	COG3279	Response regulator of the LytR AlgR family
CACET_RS18855	COG0745	RESPONSE REGULATOR receiver
CACET_RS18855	COG2972	Histidine kinase
CACET_RS18860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CACET_RS18885	COG1191	sigma factor activity
CACET_RS18895	COG0596	Alpha beta hydrolase
CACET_RS18910	COG2115	Belongs to the xylose isomerase family
CACET_RS18915	COG4214	carbohydrate transport
CACET_RS18925	COG4213	ABC transporter substrate-binding protein
CACET_RS18975	COG0577	efflux transmembrane transporter activity
CACET_RS18975	COG1136	(ABC) transporter
CACET_RS18995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CACET_RS19005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CACET_RS19010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CACET_RS19035	COG5002	protein histidine kinase activity
CACET_RS19040	COG0745	RESPONSE REGULATOR receiver
CACET_RS19050	COG1404	Belongs to the peptidase S8 family
CACET_RS19055	COG0739	heme binding
CACET_RS19085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CACET_RS19095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CACET_RS19100	COG0305	Participates in initiation and elongation during chromosome replication
CACET_RS19105	COG0359	binds to the 23S rRNA
CACET_RS19110	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CACET_RS19140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CACET_RS19145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CACET_RS19150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CACET_RS19165	COG3949	Membrane
CACET_RS19185	COG1104	cysteine desulfurase activity
CACET_RS19190	COG1475	DNA binding
CACET_RS19195	COG1192	Involved in chromosome partitioning
CACET_RS19205	COG1475	DNA binding
CACET_RS19210	COG0357	Ribosomal RNA small subunit methyltransferase G
CACET_RS19215	COG0445	tRNA wobble uridine modification
CACET_RS19220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CACET_RS19225	COG1847	R3H domain protein
CACET_RS19230	COG0706	membrane insertase activity
CACET_RS19235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CACET_RS19240	COG0594	ribonuclease P activity
CACET_RS19245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CACET_RS19285	COG0187	DNA topoisomerase II activity
CACET_RS19300	COG1361	Conserved repeat domain
CACET_RS19300	COG2911	Protein conserved in bacteria
CACET_RS19300	COG3266	domain, Protein
CACET_RS19310	COG1040	competence protein
CACET_RS19315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CACET_RS19325	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CACET_RS19340	COG3858	chitin binding
CACET_RS19345	COG3300	MHYT domain
CACET_RS19345	COG5001	Diguanylate cyclase
CACET_RS19365	COG3773	Cell wall hydrolase
CACET_RS19370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CACET_RS19375	COG1376	ErfK ybiS ycfS ynhG family protein
CACET_RS19455	COG2972	Histidine kinase
CACET_RS19480	COG0577	efflux transmembrane transporter activity
CACET_RS19480	COG1136	(ABC) transporter
CACET_RS19495	COG3568	Endonuclease Exonuclease Phosphatase
CACET_RS19510	COG0840	transmembrane signaling receptor activity
CACET_RS19515	COG2205	protein histidine kinase activity
CACET_RS19535	COG2207	Transcriptional regulator
CACET_RS19540	COG3693	PFAM glycoside hydrolase, family 10
CACET_RS19570	COG1305	Transglutaminase-like
CACET_RS19580	COG2165	general secretion pathway protein
CACET_RS19590	COG5001	Diguanylate cyclase
CACET_RS19590	COG3300	MHYT domain
CACET_RS19615	COG4585	Histidine kinase
CACET_RS19640	COG0840	transmembrane signaling receptor activity
CACET_RS19645	COG0726	polysaccharide deacetylase
CACET_RS19655	COG5002	protein histidine kinase activity
CACET_RS19665	COG0840	transmembrane signaling receptor activity
CACET_RS19670	COG5002	protein histidine kinase activity
CACET_RS19675	COG1309	transcriptional regulator