locus-tag	class	description
CURI_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CURI_RS00010	COG0592	DNA-directed DNA polymerase activity
CURI_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CURI_RS00030	COG0187	DNA topoisomerase II activity
CURI_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CURI_RS00040	COG1366	Belongs to the anti-sigma-factor antagonist family
CURI_RS00050	COG1191	sigma factor activity
CURI_RS00070	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CURI_RS00075	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CURI_RS00080	COG3639	organic phosphonate transmembrane transporter activity
CURI_RS00095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CURI_RS00105	COG0157	Belongs to the NadC ModD family
CURI_RS00135	COG0402	S-adenosylhomocysteine deaminase activity
CURI_RS00140	COG2252	PERMEase
CURI_RS00160	COG2801	Transposase and inactivated derivatives
CURI_RS00175	COG1686	Belongs to the peptidase S11 family
CURI_RS00235	COG3682	Transcriptional regulator
CURI_RS00265	COG0641	radical SAM
CURI_RS00270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CURI_RS00280	COG1131	(ABC) transporter
CURI_RS00305	COG0577	efflux transmembrane transporter activity
CURI_RS00305	COG1136	(ABC) transporter
CURI_RS00310	COG3279	Response regulator of the LytR AlgR family
CURI_RS00325	COG0527	aspartate kinase activity
CURI_RS00330	COG0460	homoserine dehydrogenase
CURI_RS00335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CURI_RS00345	COG4492	Belongs to the UPF0735 family
CURI_RS00350	COG0616	signal peptide processing
CURI_RS00355	COG1714	RDD family
CURI_RS00360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CURI_RS00365	COG0509	glycine decarboxylation via glycine cleavage system
CURI_RS00370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CURI_RS00375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CURI_RS00380	COG0321	lipoyl(octanoyl) transferase activity
CURI_RS00385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CURI_RS00395	COG0745	RESPONSE REGULATOR receiver
CURI_RS00400	COG5002	protein histidine kinase activity
CURI_RS00405	COG4978	Transcriptional regulator
CURI_RS00405	COG0789	Transcriptional regulator
CURI_RS00420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CURI_RS00435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CURI_RS00440	COG0785	Cytochrome C biogenesis protein
CURI_RS00450	COG5002	protein histidine kinase activity
CURI_RS00455	COG2207	Transcriptional regulator
CURI_RS00455	COG4753	response regulator
CURI_RS00470	COG0725	ABC transporter, periplasmic molybdate-binding protein
CURI_RS00475	COG4149	molybdate abc transporter
CURI_RS00485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CURI_RS00490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CURI_RS00495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CURI_RS00500	COG1592	Rubrerythrin
CURI_RS00510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CURI_RS00525	COG0281	malic enzyme
CURI_RS00535	COG1982	Orn Lys Arg decarboxylase major
CURI_RS00540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CURI_RS00545	COG3870	Protein conserved in bacteria
CURI_RS00550	COG1728	Protein conserved in bacteria
CURI_RS00555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CURI_RS00560	COG1774	PSP1 C-terminal conserved region
CURI_RS00565	COG2768	binding domain, Protein
CURI_RS00570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CURI_RS00575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CURI_RS00580	COG2002	toxin-antitoxin pair type II binding
CURI_RS00585	COG2715	membrane protein required for spore maturation
CURI_RS00590	COG0700	Nucleoside recognition
CURI_RS00595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CURI_RS00595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CURI_RS00600	COG0084	hydrolase, TatD family'
CURI_RS00610	COG3583	domain protein
CURI_RS00610	COG3584	3D domain protein
CURI_RS00620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CURI_RS00630	COG0640	Transcriptional regulator
CURI_RS00660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CURI_RS00670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CURI_RS00675	COG2217	Heavy metal translocating P-type atpase
CURI_RS00685	COG1937	Protein conserved in bacteria
CURI_RS00695	COG1982	Orn Lys Arg decarboxylase major
CURI_RS00700	COG0840	transmembrane signaling receptor activity
CURI_RS00715	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CURI_RS00720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CURI_RS00725	COG0010	Belongs to the arginase family
CURI_RS00735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CURI_RS00750	COG1802	Transcriptional regulator
CURI_RS00760	COG0697	spore germination
CURI_RS00765	COG0814	amino acid
CURI_RS00795	COG2959	enzyme of heme biosynthesis
CURI_RS00800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CURI_RS00815	COG1231	oxidoreductase activity
CURI_RS00840	COG3409	Peptidoglycan-binding domain 1 protein
CURI_RS00840	COG0793	Belongs to the peptidase S41A family
CURI_RS00845	COG2373	Large extracellular alpha-helical protein
CURI_RS00870	COG3693	PFAM glycoside hydrolase, family 10
CURI_RS00875	COG2201	protein-glutamate methylesterase activity
CURI_RS00890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CURI_RS00895	COG1494	fructose-1,6-bisphosphatase
CURI_RS00900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CURI_RS00905	COG0254	rRNA binding
CURI_RS00910	COG3872	metal-dependent enzyme
CURI_RS00915	COG2890	protein-(glutamine-N5) methyltransferase activity
CURI_RS00930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CURI_RS00945	COG0009	L-threonylcarbamoyladenylate synthase
CURI_RS00955	COG0698	ribose 5-phosphate isomerase
CURI_RS00960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CURI_RS00965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CURI_RS00965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CURI_RS00970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CURI_RS00975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CURI_RS00990	COG0356	it plays a direct role in the translocation of protons across the membrane
CURI_RS00995	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CURI_RS01000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CURI_RS01010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CURI_RS01015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CURI_RS01020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CURI_RS01025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CURI_RS01035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CURI_RS01040	COG2385	sporulation resulting in formation of a cellular spore
CURI_RS01050	COG1609	Transcriptional regulator
CURI_RS01055	COG1077	Cell shape determining protein MreB Mrl
CURI_RS01060	COG4786	Flagellar basal body rod
CURI_RS01060	COG4786	Flagellar basal body rod
CURI_RS01075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CURI_RS01090	COG3693	PFAM glycoside hydrolase, family 10
CURI_RS01100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CURI_RS01125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CURI_RS01160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CURI_RS01170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CURI_RS01175	COG1040	competence protein
CURI_RS01195	COG1256	bacterial-type flagellum assembly
CURI_RS01195	COG4786	Flagellar basal body rod
CURI_RS01220	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CURI_RS01225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CURI_RS01275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CURI_RS01280	COG1516	flagellar protein fliS
CURI_RS01300	COG0653	protein targeting
CURI_RS01305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CURI_RS01310	COG2183	response to ionizing radiation
CURI_RS01315	COG3852	Histidine kinase
CURI_RS01320	COG1228	amidohydrolase
CURI_RS01325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CURI_RS01330	COG0802	atpase or kinase
CURI_RS01340	COG0456	acetyltransferase
CURI_RS01350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CURI_RS01355	COG1136	(ABC) transporter
CURI_RS01370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CURI_RS01380	COG0488	(ABC) transporter
CURI_RS01385	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CURI_RS01390	COG0840	transmembrane signaling receptor activity
CURI_RS01395	COG0840	transmembrane signaling receptor activity
CURI_RS01400	COG0840	transmembrane signaling receptor activity
CURI_RS01410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CURI_RS01420	COG0745	RESPONSE REGULATOR receiver
CURI_RS01425	COG5002	protein histidine kinase activity
CURI_RS01430	COG1136	(ABC) transporter
CURI_RS01435	COG0577	efflux transmembrane transporter activity
CURI_RS01450	COG4120	Belongs to the binding-protein-dependent transport system permease family
CURI_RS01455	COG3842	ATPase activity
CURI_RS01460	COG1811	Na channel or pump
CURI_RS01475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CURI_RS01480	COG0459	protein refolding
CURI_RS01490	COG0138	bifunctional purine biosynthesis protein purh
CURI_RS01495	COG0840	transmembrane signaling receptor activity
CURI_RS01510	COG4496	protein, YerC YecD
CURI_RS01535	COG1309	transcriptional regulator
CURI_RS01540	COG0706	membrane insertase activity
CURI_RS01550	COG0210	DNA helicase
CURI_RS01555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CURI_RS01565	COG0154	amidase activity
CURI_RS01570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CURI_RS01575	COG0601	transmembrane transport
CURI_RS01580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CURI_RS01585	COG0444	Belongs to the ABC transporter superfamily
CURI_RS01590	COG4608	Belongs to the ABC transporter superfamily
CURI_RS01595	COG4166	transmembrane transport
CURI_RS01630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CURI_RS01670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CURI_RS01675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CURI_RS01690	COG0534	Mate efflux family protein
CURI_RS01705	COG0697	spore germination
CURI_RS01720	COG0740	serine-type endopeptidase activity
CURI_RS01725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CURI_RS01730	COG1388	LysM domain
CURI_RS01730	COG0791	NLP P60 protein
CURI_RS01735	COG2340	Cysteine-rich secretory protein family
CURI_RS01740	COG0534	Mate efflux family protein
CURI_RS01755	COG0803	Belongs to the bacterial solute-binding protein 9 family
CURI_RS01760	COG1121	(ABC) transporter
CURI_RS01765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CURI_RS01770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CURI_RS01815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CURI_RS01840	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CURI_RS01875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CURI_RS01895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CURI_RS01925	COG1131	(ABC) transporter
CURI_RS01930	COG0789	Transcriptional regulator
CURI_RS01940	COG0840	transmembrane signaling receptor activity
CURI_RS01940	COG2203	Gaf domain
CURI_RS01945	COG3481	metal-dependent phosphohydrolase, HD sub domain
CURI_RS01950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS01955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS01970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS01975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS01985	COG1132	(ABC) transporter
CURI_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CURI_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CURI_RS02000	COG1120	ATPase activity
CURI_RS02005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CURI_RS02010	COG0662	Cupin 2, conserved barrel domain protein
CURI_RS02010	COG2207	Transcriptional regulator
CURI_RS02020	COG2188	Transcriptional regulator
CURI_RS02025	COG2364	Membrane
CURI_RS02040	COG1132	(ABC) transporter
CURI_RS02045	COG0655	NAD(P)H dehydrogenase (quinone) activity
CURI_RS02050	COG2873	o-acetylhomoserine
CURI_RS02055	COG2199	diguanylate cyclase activity
CURI_RS02055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CURI_RS02060	COG1115	amino acid carrier protein
CURI_RS02100	COG0456	acetyltransferase
CURI_RS02110	COG1917	Cupin 2, conserved barrel domain protein
CURI_RS02110	COG2207	Transcriptional regulator
CURI_RS02115	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CURI_RS02120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CURI_RS02125	COG0778	Nitroreductase
CURI_RS02150	COG1924	4 iron, 4 sulfur cluster binding
CURI_RS02155	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CURI_RS02160	COG1509	lysine 2,3-aminomutase activity
CURI_RS02170	COG1475	DNA binding
CURI_RS02200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CURI_RS02220	COG1396	sequence-specific DNA binding
CURI_RS02255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS02280	COG0740	serine-type endopeptidase activity
CURI_RS02285	COG0488	(ABC) transporter
CURI_RS02295	COG0789	Transcriptional regulator
CURI_RS02310	COG0745	RESPONSE REGULATOR receiver
CURI_RS02315	COG5002	protein histidine kinase activity
CURI_RS02355	COG0745	RESPONSE REGULATOR receiver
CURI_RS02360	COG2205	protein histidine kinase activity
CURI_RS02365	COG1136	(ABC) transporter
CURI_RS02380	COG0277	FAD linked oxidase domain protein
CURI_RS02400	COG0583	DNA-binding transcription factor activity
CURI_RS02405	COG1136	(ABC) transporter
CURI_RS02415	COG0745	RESPONSE REGULATOR receiver
CURI_RS02420	COG2205	protein histidine kinase activity
CURI_RS02445	COG5002	protein histidine kinase activity
CURI_RS02460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS02470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CURI_RS02475	COG1120	ATPase activity
CURI_RS02485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CURI_RS02515	COG4716	Myosin-crossreactive antigen
CURI_RS02520	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CURI_RS02525	COG2957	Belongs to the agmatine deiminase family
CURI_RS02535	COG2720	vancomycin resistance protein
CURI_RS02540	COG1181	Belongs to the D-alanine--D-alanine ligase family
CURI_RS02555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CURI_RS02565	COG0860	N-Acetylmuramoyl-L-alanine amidase
CURI_RS02580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CURI_RS02605	COG2357	RelA SpoT domain protein
CURI_RS02610	COG1131	(ABC) transporter
CURI_RS02630	COG1131	(ABC) transporter
CURI_RS02645	COG0745	RESPONSE REGULATOR receiver
CURI_RS02650	COG2205	protein histidine kinase activity
CURI_RS02685	COG0726	polysaccharide deacetylase
CURI_RS02695	COG0784	Response regulator, receiver
CURI_RS02700	COG1115	amino acid carrier protein
CURI_RS02705	COG0069	glutamate synthase activity
CURI_RS02720	COG1595	DNA-templated transcription, initiation
CURI_RS02740	COG5002	protein histidine kinase activity
CURI_RS02745	COG0577	efflux transmembrane transporter activity
CURI_RS02745	COG1136	(ABC) transporter
CURI_RS02750	COG1595	DNA-templated transcription, initiation
CURI_RS02765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CURI_RS02775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CURI_RS02785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CURI_RS02790	COG0402	S-adenosylhomocysteine deaminase activity
CURI_RS02800	COG0617	tRNA 3'-terminal CCA addition
CURI_RS02800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CURI_RS02800	COG3620	sequence-specific DNA binding
CURI_RS02825	COG0534	Mate efflux family protein
CURI_RS02830	COG2770	Histidine kinase
CURI_RS02830	COG3437	response regulator, receiver
CURI_RS02835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CURI_RS02840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CURI_RS02845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CURI_RS02905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CURI_RS02910	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CURI_RS02915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CURI_RS02920	COG1741	Belongs to the pirin family
CURI_RS02945	COG1217	gtp-binding protein TYPA
CURI_RS02970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CURI_RS02980	COG0450	alkyl hydroperoxide reductase
CURI_RS02985	COG3842	ATPase activity
CURI_RS02995	COG0166	Belongs to the GPI family
CURI_RS03000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CURI_RS03010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CURI_RS03015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CURI_RS03020	COG0297	glycogen (starch) synthase activity
CURI_RS03025	COG0058	SHG alpha-glucan phosphorylase activity
CURI_RS03045	COG1053	succinate dehydrogenase
CURI_RS03045	COG0431	NADPH-dependent FMN reductase
CURI_RS03045	COG3976	FMN-binding domain protein
CURI_RS03050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CURI_RS03055	COG2323	membrane
CURI_RS03060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CURI_RS03085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CURI_RS03090	COG1924	4 iron, 4 sulfur cluster binding
CURI_RS03100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CURI_RS03150	COG1518	maintenance of DNA repeat elements
CURI_RS03155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CURI_RS03170	COG1307	EDD domain protein, DegV family
CURI_RS03190	COG1132	(ABC) transporter
CURI_RS03210	COG0671	phosphoesterase, PA-phosphatase related
CURI_RS03215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CURI_RS03220	COG0765	amino acid transport
CURI_RS03225	COG3263	regulation of cellular component size
CURI_RS03230	COG2217	Heavy metal translocating P-type atpase
CURI_RS03235	COG2234	aminopeptidase activity
CURI_RS03250	COG1151	hydroxylamine reductase activity
CURI_RS03260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CURI_RS03265	COG1116	anion transmembrane transporter activity
CURI_RS03295	COG0069	glutamate synthase activity
CURI_RS03355	COG3279	Response regulator of the LytR AlgR family
CURI_RS03385	COG4565	transcriptional regulatory protein
CURI_RS03395	COG3290	protein histidine kinase activity
CURI_RS03405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CURI_RS03415	COG0134	indole-3-glycerol-phosphate synthase activity
CURI_RS03425	COG0133	tryptophan synthase activity
CURI_RS03440	COG1132	(ABC) transporter
CURI_RS03445	COG1132	(ABC) transporter
CURI_RS03450	COG2070	2-Nitropropane dioxygenase
CURI_RS03460	COG0312	modulator of DNA gyrase
CURI_RS03465	COG0312	modulator of DNA gyrase
CURI_RS03470	COG2155	Conserved Protein
CURI_RS03485	COG1533	DNA photolyase activity
CURI_RS03495	COG0165	Argininosuccinate lyase
CURI_RS03510	COG0574	Belongs to the PEP-utilizing enzyme family
CURI_RS03510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CURI_RS03525	COG1695	Transcriptional regulator
CURI_RS03540	COG2011	ABC-type metal ion transport system permease component
CURI_RS03545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CURI_RS03560	COG0540	Belongs to the ATCase OTCase family
CURI_RS03565	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CURI_RS03575	COG0284	orotidine-5'-phosphate decarboxylase activity
CURI_RS03585	COG0167	dihydroorotate dehydrogenase activity
CURI_RS03600	COG2226	methyltransferase
CURI_RS03610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CURI_RS03625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CURI_RS03645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CURI_RS03665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CURI_RS03670	COG1459	type II secretion system
CURI_RS03685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CURI_RS03710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CURI_RS03715	COG3585	molybdate ion transport
CURI_RS03720	COG0840	transmembrane signaling receptor activity
CURI_RS03740	COG2244	polysaccharide biosynthetic process
CURI_RS03750	COG0457	Tetratricopeptide repeat
CURI_RS03750	COG0463	Glycosyl transferase, family 2
CURI_RS03760	COG0765	amino acid transport
CURI_RS03765	COG1126	abc transporter atp-binding protein
CURI_RS03775	COG0840	transmembrane signaling receptor activity
CURI_RS03810	COG0519	Catalyzes the synthesis of GMP from XMP
CURI_RS03820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CURI_RS03825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CURI_RS03825	COG0456	acetyltransferase
CURI_RS03850	COG0024	Methionine aminopeptidase
CURI_RS03860	COG0488	(ABC) transporter
CURI_RS03870	COG2364	Membrane
CURI_RS03880	COG0697	spore germination
CURI_RS03890	COG3800	Transcriptional regulator
CURI_RS03890	COG1396	sequence-specific DNA binding
CURI_RS03895	COG2378	regulation of single-species biofilm formation
CURI_RS03905	COG0662	Cupin 2, conserved barrel domain protein
CURI_RS03910	COG2323	membrane
CURI_RS03920	COG0745	RESPONSE REGULATOR receiver
CURI_RS03925	COG5002	protein histidine kinase activity
CURI_RS03930	COG1136	(ABC) transporter
CURI_RS03970	COG1132	(ABC) transporter
CURI_RS03975	COG3279	Response regulator of the LytR AlgR family
CURI_RS03985	COG4512	PFAM Accessory gene regulator B
CURI_RS03995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CURI_RS04005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CURI_RS04005	COG1181	Belongs to the D-alanine--D-alanine ligase family
CURI_RS04010	COG0784	Response regulator, receiver
CURI_RS04010	COG2205	protein histidine kinase activity
CURI_RS04015	COG1309	transcriptional regulator
CURI_RS04025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CURI_RS04050	COG1278	Cold shock
CURI_RS04060	COG3585	molybdate ion transport
CURI_RS04080	COG1136	(ABC) transporter
CURI_RS04095	COG1136	(ABC) transporter
CURI_RS04105	COG1331	Highly conserved protein containing a thioredoxin domain
CURI_RS04115	COG1511	domain protein
CURI_RS04120	COG0180	Tryptophanyl-tRNA synthetase
CURI_RS04130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CURI_RS04135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CURI_RS04140	COG0617	tRNA 3'-terminal CCA addition
CURI_RS04155	COG0525	valine-tRNA ligase activity
CURI_RS04170	COG0515	serine threonine protein kinase
CURI_RS04205	COG1283	sodium-dependent phosphate transmembrane transporter activity
CURI_RS04210	COG0688	phosphatidylethanolamine metabolic process
CURI_RS04215	COG0726	polysaccharide deacetylase
CURI_RS04225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CURI_RS04235	COG0402	S-adenosylhomocysteine deaminase activity
CURI_RS04245	COG0643	Histidine kinase
CURI_RS04245	COG2198	Histidine kinase
CURI_RS04250	COG0835	chemotaxis
CURI_RS04255	COG0840	transmembrane signaling receptor activity
CURI_RS04265	COG2201	protein-glutamate methylesterase activity
CURI_RS04275	COG2226	methyltransferase
CURI_RS04280	COG1278	Cold shock
CURI_RS04285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CURI_RS04310	COG4399	Belongs to the UPF0754 family
CURI_RS04320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CURI_RS04325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CURI_RS04330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CURI_RS04335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CURI_RS04340	COG0569	domain protein
CURI_RS04345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CURI_RS04350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CURI_RS04365	COG2323	membrane
CURI_RS04370	COG0826	peptidase U32
CURI_RS04375	COG1193	negative regulation of DNA recombination
CURI_RS04380	COG1683	Conserved Protein
CURI_RS04390	COG0018	arginyl-trna synthetase
CURI_RS04400	COG1595	DNA-templated transcription, initiation
CURI_RS04530	COG0640	Transcriptional regulator
CURI_RS04535	COG5658	integral membrane protein
CURI_RS04755	COG1924	4 iron, 4 sulfur cluster binding
CURI_RS04775	COG1104	cysteine desulfurase activity
CURI_RS04780	COG0301	tRNA thio-modification
CURI_RS04785	COG1704	LemA family
CURI_RS04795	COG0803	Belongs to the bacterial solute-binding protein 9 family
CURI_RS04800	COG1121	(ABC) transporter
CURI_RS04805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CURI_RS04810	COG1396	sequence-specific DNA binding
CURI_RS04815	COG3842	ATPase activity
CURI_RS04820	COG1176	ABC-type spermidine putrescine transport system, permease component I
CURI_RS04825	COG1177	transmembrane transport
CURI_RS04835	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CURI_RS04845	COG1983	PspC domain protein
CURI_RS04860	COG0768	penicillin binding
CURI_RS04875	COG1164	Oligoendopeptidase f
CURI_RS04880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CURI_RS04895	COG0564	pseudouridine synthase activity
CURI_RS04915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CURI_RS04940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CURI_RS04950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CURI_RS04955	COG1597	lipid kinase activity
CURI_RS04965	COG0835	chemotaxis
CURI_RS04970	COG1362	aminopeptidase activity
CURI_RS04975	COG0583	DNA-binding transcription factor activity
CURI_RS04995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CURI_RS04995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CURI_RS05000	COG0237	dephospho-CoA kinase activity
CURI_RS05015	COG0747	negative chemotaxis
CURI_RS05025	COG1028	Short-chain dehydrogenase reductase Sdr
CURI_RS05035	COG4656	Part of a membrane complex involved in electron transport
CURI_RS05040	COG4658	electron transport chain
CURI_RS05045	COG4659	FMN binding
CURI_RS05050	COG4660	Part of a membrane complex involved in electron transport
CURI_RS05055	COG4657	Part of a membrane complex involved in electron transport
CURI_RS05060	COG1245	4Fe-4S binding domain
CURI_RS05060	COG2878	Part of a membrane complex involved in electron transport
CURI_RS05075	COG0424	maF-like protein
CURI_RS05080	COG2003	Belongs to the UPF0758 family
CURI_RS05085	COG1077	Cell shape determining protein MreB Mrl
CURI_RS05090	COG1792	Involved in formation and maintenance of cell shape
CURI_RS05125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CURI_RS05130	COG1649	PFAM Uncharacterised BCR, COG1649
CURI_RS05145	COG4175	Glycine betaine
CURI_RS05145	COG0517	IMP dehydrogenase activity
CURI_RS05160	COG0628	permease
CURI_RS05170	COG0123	including yeast histone deacetylase and acetoin utilization protein
CURI_RS05185	COG2078	PFAM AMMECR1 domain protein
CURI_RS05185	COG3885	ferrous iron binding
CURI_RS05195	COG1396	sequence-specific DNA binding
CURI_RS05205	COG1366	Belongs to the anti-sigma-factor antagonist family
CURI_RS05210	COG2172	sigma factor antagonist activity
CURI_RS05215	COG1191	sigma factor activity
CURI_RS05225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CURI_RS05245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CURI_RS05255	COG1739	Uncharacterized protein family UPF0029
CURI_RS05260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CURI_RS05270	COG0730	response to heat
CURI_RS05275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CURI_RS05280	COG0217	transcriptional regulatory protein
CURI_RS05290	COG0534	Mate efflux family protein
CURI_RS05295	COG2268	Band 7 protein
CURI_RS05300	COG2878	Part of a membrane complex involved in electron transport
CURI_RS05300	COG1245	4Fe-4S binding domain
CURI_RS05305	COG3842	ATPase activity
CURI_RS05310	COG4208	sulfate ABC transporter
CURI_RS05330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CURI_RS05335	COG0632	four-way junction helicase activity
CURI_RS05340	COG2255	four-way junction helicase activity
CURI_RS05345	COG2247	cell wall binding repeat
CURI_RS05345	COG2385	sporulation resulting in formation of a cellular spore
CURI_RS05360	COG0343	queuine tRNA-ribosyltransferase activity
CURI_RS05365	COG1862	Preprotein translocase
CURI_RS05370	COG1242	4 iron, 4 sulfur cluster binding
CURI_RS05375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CURI_RS05380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CURI_RS05380	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CURI_RS05385	COG1187	pseudouridine synthase activity
CURI_RS05410	COG0517	IMP dehydrogenase activity
CURI_RS05420	COG0772	Belongs to the SEDS family
CURI_RS05425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CURI_RS05430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CURI_RS05435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CURI_RS05445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CURI_RS05450	COG0849	cell division
CURI_RS05455	COG2720	vancomycin resistance protein
CURI_RS05475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CURI_RS05475	COG2080	2 iron, 2 sulfur cluster binding
CURI_RS05505	COG0126	phosphoglycerate kinase activity
CURI_RS05510	COG0149	triose-phosphate isomerase activity
CURI_RS05515	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CURI_RS05520	COG0148	phosphopyruvate hydratase activity
CURI_RS05535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CURI_RS05540	COG1181	Belongs to the D-alanine--D-alanine ligase family
CURI_RS05545	COG0557	exoribonuclease II activity
CURI_RS05550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CURI_RS05615	COG1733	regulation of RNA biosynthetic process
CURI_RS05620	COG0346	lactoylglutathione lyase activity
CURI_RS05630	COG5002	protein histidine kinase activity
CURI_RS05635	COG0708	Exodeoxyribonuclease III
CURI_RS05645	COG3976	FMN-binding domain protein
CURI_RS05645	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CURI_RS05665	COG1272	protein, Hemolysin III
CURI_RS05675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CURI_RS05685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CURI_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
CURI_RS05705	COG2971	BadF BadG BcrA BcrD
CURI_RS05730	COG1671	Belongs to the UPF0178 family
CURI_RS05740	COG0747	negative chemotaxis
CURI_RS05745	COG0601	transmembrane transport
CURI_RS05755	COG0444	Belongs to the ABC transporter superfamily
CURI_RS05760	COG4608	Belongs to the ABC transporter superfamily
CURI_RS05780	COG1464	Belongs to the NlpA lipoprotein family
CURI_RS05785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CURI_RS05790	COG2011	ABC-type metal ion transport system permease component
CURI_RS05795	COG1464	Belongs to the NlpA lipoprotein family
CURI_RS05800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CURI_RS05810	COG1464	Belongs to the NlpA lipoprotein family
CURI_RS05815	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CURI_RS05820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CURI_RS05840	COG5012	cobalamin binding
CURI_RS05890	COG0352	thiamine-phosphate diphosphorylase activity
CURI_RS05900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CURI_RS05905	COG2022	thiamine diphosphate biosynthetic process
CURI_RS05920	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CURI_RS05925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CURI_RS05955	COG0612	Peptidase, M16
CURI_RS05960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CURI_RS05965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CURI_RS05970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CURI_RS05980	COG0019	diaminopimelate decarboxylase activity
CURI_RS05985	COG0493	'glutamate synthase
CURI_RS05990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CURI_RS05995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CURI_RS06010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CURI_RS06015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CURI_RS06020	COG2357	RelA SpoT domain protein
CURI_RS06030	COG1307	EDD domain protein, DegV family
CURI_RS06055	COG0482	sulfurtransferase activity
CURI_RS06060	COG1686	Belongs to the peptidase S11 family
CURI_RS06100	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CURI_RS06115	COG5002	protein histidine kinase activity
CURI_RS06120	COG1136	(ABC) transporter
CURI_RS06130	COG1595	DNA-templated transcription, initiation
CURI_RS06145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CURI_RS06150	COG0028	Belongs to the TPP enzyme family
CURI_RS06155	COG0440	acetolactate synthase activity
CURI_RS06160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CURI_RS06175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CURI_RS06180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CURI_RS06185	COG0077	Prephenate dehydratase
CURI_RS06185	COG1605	Chorismate mutase
CURI_RS06195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CURI_RS06200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CURI_RS06205	COG2094	Belongs to the DNA glycosylase MPG family
CURI_RS06215	COG0066	3-isopropylmalate dehydratase activity
CURI_RS06220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CURI_RS06225	COG0473	3-isopropylmalate dehydrogenase activity
CURI_RS06230	COG0583	DNA-binding transcription factor activity
CURI_RS06235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CURI_RS06240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CURI_RS06245	COG0129	dihydroxy-acid dehydratase activity
CURI_RS06250	COG0028	Belongs to the TPP enzyme family
CURI_RS06280	COG0484	heat shock protein binding
CURI_RS06290	COG0658	competence protein
CURI_RS06290	COG2333	competence protein COMEC
CURI_RS06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CURI_RS06305	COG0765	amino acid transport
CURI_RS06340	COG4869	propanediol catabolic process
CURI_RS06355	COG3706	GGDEF domain
CURI_RS06360	COG0488	(ABC) transporter
CURI_RS06400	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CURI_RS06440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CURI_RS06445	COG1459	type II secretion system
CURI_RS06455	COG1846	Transcriptional regulator
CURI_RS06475	COG0012	GTP binding
CURI_RS06480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CURI_RS06485	COG0573	inorganic phosphate transmembrane transporter activity
CURI_RS06490	COG0581	inorganic phosphate transmembrane transporter activity
CURI_RS06495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CURI_RS06500	COG0704	Plays a role in the regulation of phosphate uptake
CURI_RS06520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CURI_RS06525	COG0275	rRNA processing
CURI_RS06535	COG0768	penicillin binding
CURI_RS06540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CURI_RS06545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CURI_RS06550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CURI_RS06555	COG0772	Belongs to the SEDS family
CURI_RS06560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CURI_RS06565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CURI_RS06585	COG3856	small basic protein
CURI_RS06590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CURI_RS06600	COG1191	sigma factor activity
CURI_RS06610	COG1873	PFAM PRC-barrel domain
CURI_RS06615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CURI_RS06625	COG0745	RESPONSE REGULATOR receiver
CURI_RS06630	COG5002	protein histidine kinase activity
CURI_RS06645	COG0017	Asparaginyl-tRNA synthetase
CURI_RS06650	COG0653	protein targeting
CURI_RS06660	COG3858	chitin binding
CURI_RS06695	COG1959	2 iron, 2 sulfur cluster binding
CURI_RS06705	COG0822	iron-sulfur transferase activity
CURI_RS06710	COG0482	sulfurtransferase activity
CURI_RS06720	COG0628	permease
CURI_RS06725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CURI_RS06730	COG4472	Bacterial protein of unknown function (DUF965)
CURI_RS06740	COG0667	Aldo Keto reductase
CURI_RS06745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CURI_RS06750	COG3906	Belongs to the UPF0473 family
CURI_RS06755	COG0735	belongs to the Fur family
CURI_RS06760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CURI_RS06775	COG4122	O-methyltransferase activity
CURI_RS06780	COG0826	peptidase U32
CURI_RS06830	COG2140	Oxalate decarboxylase
CURI_RS06860	COG1191	sigma factor activity
CURI_RS06870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CURI_RS06875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CURI_RS06900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CURI_RS06910	COG3854	ATPases associated with a variety of cellular activities
CURI_RS06950	COG1302	Protein conserved in bacteria
CURI_RS06965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CURI_RS06970	COG1570	exodeoxyribonuclease VII activity
CURI_RS06975	COG1722	exodeoxyribonuclease VII activity
CURI_RS06985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CURI_RS06990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CURI_RS06995	COG1438	arginine binding
CURI_RS07000	COG0497	DNA recombination
CURI_RS07005	COG0750	zinc metalloprotease
CURI_RS07040	COG0463	Glycosyl transferase, family 2
CURI_RS07060	COG1300	Membrane
CURI_RS07065	COG4974	Belongs to the 'phage' integrase family
CURI_RS07075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CURI_RS07085	COG2267	carboxylic ester hydrolase activity
CURI_RS07095	COG1994	Peptidase M50
CURI_RS07100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CURI_RS07105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CURI_RS07115	COG3874	Sporulation protein YtfJ
CURI_RS07120	COG1686	Belongs to the peptidase S11 family
CURI_RS07130	COG0445	tRNA wobble uridine modification
CURI_RS07135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CURI_RS07185	COG1187	pseudouridine synthase activity
CURI_RS07195	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CURI_RS07200	COG1737	Transcriptional regulator
CURI_RS07210	COG2081	HI0933 family
CURI_RS07215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CURI_RS07220	COG0318	PFAM AMP-dependent synthetase and ligase
CURI_RS07220	COG0204	Acyl-transferase
CURI_RS07225	COG0539	negative regulation of cytoplasmic translation
CURI_RS07225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CURI_RS07230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CURI_RS07255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CURI_RS07265	COG0242	peptide deformylase activity
CURI_RS07270	COG0456	acetyltransferase
CURI_RS07280	COG1794	racemase activity, acting on amino acids and derivatives
CURI_RS07285	COG0237	dephospho-CoA kinase activity
CURI_RS07305	COG2207	Transcriptional regulator
CURI_RS07305	COG3708	Transcriptional regulator
CURI_RS07315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CURI_RS07455	COG2801	Transposase and inactivated derivatives
CURI_RS07525	COG3299	homolog of phage Mu protein gp47
CURI_RS07570	COG0604	alcohol dehydrogenase
CURI_RS07575	COG1733	regulation of RNA biosynthetic process
CURI_RS07590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CURI_RS07595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CURI_RS07600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CURI_RS07605	COG1923	regulation of RNA biosynthetic process
CURI_RS07610	COG0464	growth
CURI_RS07615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CURI_RS07625	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CURI_RS07630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CURI_RS07635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CURI_RS07645	COG0110	maltose O-acetyltransferase activity
CURI_RS07650	COG4974	Belongs to the 'phage' integrase family
CURI_RS07655	COG0791	NLP P60 protein
CURI_RS07660	COG2264	protein methyltransferase activity
CURI_RS07665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CURI_RS07670	COG1854	S-ribosylhomocysteine lyase activity
CURI_RS07675	COG1472	Belongs to the glycosyl hydrolase 3 family
CURI_RS07695	COG0613	PHP domain protein
CURI_RS07700	COG2359	stage V sporulation protein S
CURI_RS07710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CURI_RS07715	COG1546	Belongs to the CinA family
CURI_RS07715	COG1058	Belongs to the CinA family
CURI_RS07720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CURI_RS07725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CURI_RS07730	COG1674	ftsk spoiiie
CURI_RS07735	COG0740	serine-type endopeptidase activity
CURI_RS07740	COG1873	PFAM PRC-barrel domain
CURI_RS07745	COG0612	Peptidase, M16
CURI_RS07750	COG0726	polysaccharide deacetylase
CURI_RS07755	COG1185	polyribonucleotide nucleotidyltransferase activity
CURI_RS07765	COG0196	riboflavin kinase activity
CURI_RS07770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CURI_RS07775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CURI_RS07780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CURI_RS07785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CURI_RS07795	COG0195	Participates in both transcription termination and antitermination
CURI_RS07800	COG0779	Required for maturation of 30S ribosomal subunits
CURI_RS07810	COG1285	pathogenesis
CURI_RS07815	COG0463	Glycosyl transferase, family 2
CURI_RS07825	COG0750	zinc metalloprotease
CURI_RS07830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CURI_RS07835	COG4589	Belongs to the CDS family
CURI_RS07845	COG0233	cytoplasmic translational termination
CURI_RS07850	COG0528	UMP kinase activity
CURI_RS07855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CURI_RS07860	COG0052	Belongs to the universal ribosomal protein uS2 family
CURI_RS07880	COG1191	sigma factor activity
CURI_RS07885	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CURI_RS07890	COG1776	CheC inhibitor of MCP methylation
CURI_RS07895	COG0835	chemotaxis
CURI_RS07900	COG2198	Histidine kinase
CURI_RS07900	COG0643	Histidine kinase
CURI_RS07910	COG1419	protein localization to endoplasmic reticulum
CURI_RS07915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CURI_RS07920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CURI_RS07925	COG1684	flagellar biosynthetic protein fliR
CURI_RS07930	COG1987	bacterial-type flagellum assembly
CURI_RS07935	COG1338	Plays a role in the flagellum-specific transport system
CURI_RS07945	COG2201	protein-glutamate methylesterase activity
CURI_RS07950	COG1776	CheC inhibitor of MCP methylation
CURI_RS07950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CURI_RS07955	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CURI_RS07975	COG1582	Flagellar protein (FlbD)
CURI_RS07995	COG3144	bacterial-type flagellum assembly
CURI_RS08010	COG1157	protein secretion by the type III secretion system
CURI_RS08020	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CURI_RS08030	COG1677	Flagellar hook-basal body complex protein FliE
CURI_RS08035	COG1558	bacterial-type flagellum-dependent cell motility
CURI_RS08040	COG1815	bacterial-type flagellum-dependent cell motility
CURI_RS08045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CURI_RS08050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CURI_RS08055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CURI_RS08060	COG0758	DNA mediated transformation
CURI_RS08070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CURI_RS08075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CURI_RS08095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CURI_RS08100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CURI_RS08110	COG0336	Belongs to the RNA methyltransferase TrmD family
CURI_RS08115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CURI_RS08120	COG1837	Belongs to the UPF0109 family
CURI_RS08125	COG0228	four-way junction DNA binding
CURI_RS08130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CURI_RS08135	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CURI_RS08140	COG0552	protein localization to endoplasmic reticulum
CURI_RS08160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CURI_RS08165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CURI_RS08170	COG1028	Short-chain dehydrogenase reductase Sdr
CURI_RS08175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CURI_RS08185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CURI_RS08190	COG0416	fatty acid biosynthetic process
CURI_RS08200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CURI_RS08210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CURI_RS08290	COG1323	Belongs to the UPF0348 family
CURI_RS08295	COG1752	Esterase of the alpha-beta hydrolase superfamily
CURI_RS08300	COG3314	Sporulation integral membrane protein YlbJ
CURI_RS08310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CURI_RS08315	COG0742	ribosomal rna small subunit methyltransferase
CURI_RS08320	COG3383	formate dehydrogenase (NAD+) activity
CURI_RS08325	COG3383	formate dehydrogenase (NAD+) activity
CURI_RS08330	COG1763	Mo-molybdopterin cofactor biosynthetic process
CURI_RS08335	COG0303	'Molybdopterin
CURI_RS08340	COG3383	formate dehydrogenase (NAD+) activity
CURI_RS08350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CURI_RS08360	COG1461	Dihydroxyacetone kinase
CURI_RS08365	COG1302	Protein conserved in bacteria
CURI_RS08370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CURI_RS08375	COG1564	THIamine pyrophosphokinase
CURI_RS08385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CURI_RS08390	COG1162	GTPase activity
CURI_RS08395	COG2815	serine threonine protein kinase
CURI_RS08395	COG0515	serine threonine protein kinase
CURI_RS08400	COG0631	protein serine/threonine phosphatase activity
CURI_RS08405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CURI_RS08410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CURI_RS08410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CURI_RS08415	COG2738	Putative neutral zinc metallopeptidase
CURI_RS08425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CURI_RS08435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CURI_RS08440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CURI_RS08450	COG0194	GDP metabolic process
CURI_RS08460	COG1561	YicC-like family, N-terminal region
CURI_RS08465	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CURI_RS08470	COG2233	PERMEase
CURI_RS08475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CURI_RS08480	COG0564	pseudouridine synthase activity
CURI_RS08485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CURI_RS08500	COG3599	regulation of cell shape
CURI_RS08505	COG2302	S4 RNA-binding domain
CURI_RS08510	COG1799	cell septum assembly
CURI_RS08515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CURI_RS08530	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CURI_RS08535	COG4443	Transcriptional Coactivator p15 (PC4)
CURI_RS08540	COG2226	methyltransferase
CURI_RS08545	COG0675	Transposase, IS605 OrfB family
CURI_RS08560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CURI_RS08565	COG0581	inorganic phosphate transmembrane transporter activity
CURI_RS08570	COG0573	inorganic phosphate transmembrane transporter activity
CURI_RS08580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CURI_RS08585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CURI_RS08590	COG1160	GTP binding
CURI_RS08630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CURI_RS08650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CURI_RS08655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CURI_RS08660	COG0124	histidyl-tRNA synthetase
CURI_RS08665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CURI_RS08675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CURI_RS08680	COG1490	D-aminoacyl-tRNA deacylase activity
CURI_RS08685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CURI_RS08690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CURI_RS08705	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CURI_RS08705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CURI_RS08715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CURI_RS08720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CURI_RS08730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CURI_RS08740	COG0726	polysaccharide deacetylase
CURI_RS08760	COG0140	phosphoribosyl-ATP diphosphatase activity
CURI_RS08765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CURI_RS08770	COG0107	imidazoleglycerol-phosphate synthase activity
CURI_RS08775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CURI_RS08780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CURI_RS08785	COG0131	Imidazoleglycerol-phosphate dehydratase
CURI_RS08790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CURI_RS08795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CURI_RS08800	COG0124	histidyl-tRNA synthetase
CURI_RS08805	COG0561	phosphatase activity
CURI_RS08810	COG2137	regulation of response to DNA damage stimulus
CURI_RS08815	COG1362	aminopeptidase activity
CURI_RS08820	COG3906	Belongs to the UPF0473 family
CURI_RS08825	COG2195	Cleaves the N-terminal amino acid of tripeptides
CURI_RS08830	COG1982	Orn Lys Arg decarboxylase major
CURI_RS08850	COG1760	l-serine dehydratase
CURI_RS08865	COG0352	thiamine-phosphate diphosphorylase activity
CURI_RS08865	COG0351	phosphomethylpyrimidine kinase
CURI_RS08870	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CURI_RS08885	COG1846	Transcriptional regulator
CURI_RS08890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CURI_RS08910	COG1366	Belongs to the anti-sigma-factor antagonist family
CURI_RS08915	COG0840	transmembrane signaling receptor activity
CURI_RS08925	COG2873	o-acetylhomoserine
CURI_RS08930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CURI_RS08935	COG0835	chemotaxis
CURI_RS08935	COG0784	Response regulator, receiver
CURI_RS08950	COG1328	CTP reductase activity
CURI_RS08955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CURI_RS08960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CURI_RS08970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CURI_RS08980	COG0534	Mate efflux family protein
CURI_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
CURI_RS09005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CURI_RS09010	COG2384	SAM-dependent methyltransferase
CURI_RS09020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CURI_RS09025	COG0358	DNA primase activity
CURI_RS09030	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CURI_RS09035	COG0517	IMP dehydrogenase activity
CURI_RS09040	COG0423	glycine-tRNA ligase activity
CURI_RS09045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CURI_RS09050	COG1381	Involved in DNA repair and RecF pathway recombination
CURI_RS09055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CURI_RS09060	COG0295	cytidine deaminase activity
CURI_RS09065	COG1470	cell adhesion involved in biofilm formation
CURI_RS09075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CURI_RS09080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CURI_RS09085	COG1480	7TM receptor with intracellular HD hydrolase
CURI_RS09090	COG1702	phosphate starvation-inducible protein PhoH
CURI_RS09105	COG1610	YqeY-like protein
CURI_RS09110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CURI_RS09115	COG0537	adenosine 5'-monophosphoramidase activity
CURI_RS09120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CURI_RS09125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CURI_RS09130	COG2264	protein methyltransferase activity
CURI_RS09135	COG1132	(ABC) transporter
CURI_RS09145	COG0484	heat shock protein binding
CURI_RS09150	COG0443	Heat shock 70 kDa protein
CURI_RS09165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CURI_RS09170	COG0481	GTPase activity
CURI_RS09190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CURI_RS09195	COG0268	Binds directly to 16S ribosomal RNA
CURI_RS09200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CURI_RS09205	COG1466	dna polymerase III delta subunit
CURI_RS09210	COG0658	competence protein
CURI_RS09210	COG2333	competence protein COMEC
CURI_RS09215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CURI_RS09220	COG2703	oxygen carrier activity
CURI_RS09225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CURI_RS09240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CURI_RS09245	COG3655	Transcriptional regulator
CURI_RS09255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CURI_RS09260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CURI_RS09270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CURI_RS09275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CURI_RS09285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CURI_RS09315	COG1846	Transcriptional regulator
CURI_RS09325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CURI_RS09330	COG1619	proteins homologs of microcin C7 resistance protein MccF
CURI_RS09335	COG0697	spore germination
CURI_RS09370	COG1725	Transcriptional regulator
CURI_RS09375	COG1234	tRNA 3'-trailer cleavage
CURI_RS09405	COG1393	Belongs to the ArsC family
CURI_RS09410	COG1968	undecaprenyl-diphosphatase activity
CURI_RS09415	COG0288	reversible hydration of carbon dioxide
CURI_RS09435	COG1595	DNA-templated transcription, initiation
CURI_RS09450	COG1114	Component of the transport system for branched-chain amino acids
CURI_RS09460	COG1846	Transcriptional regulator
CURI_RS09470	COG0577	efflux transmembrane transporter activity
CURI_RS09475	COG1136	(ABC) transporter
CURI_RS09485	COG0745	RESPONSE REGULATOR receiver
CURI_RS09500	COG1476	TRANSCRIPTIONal
CURI_RS09530	COG0419	ATPase involved in DNA repair
CURI_RS09545	COG0420	3'-5' exonuclease activity
CURI_RS09555	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CURI_RS09570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS09580	COG1126	abc transporter atp-binding protein
CURI_RS09625	COG1120	ATPase activity
CURI_RS09630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CURI_RS09635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS09660	COG1846	Transcriptional regulator
CURI_RS09680	COG2205	protein histidine kinase activity
CURI_RS09685	COG0745	RESPONSE REGULATOR receiver
CURI_RS09705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CURI_RS09730	COG0402	S-adenosylhomocysteine deaminase activity
CURI_RS09735	COG2252	PERMEase
CURI_RS09740	COG3442	glutamine amidotransferase
CURI_RS09745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CURI_RS09750	COG3842	ATPase activity
CURI_RS09770	COG1175	transmembrane transport
CURI_RS09820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CURI_RS09825	COG0778	Nitroreductase
CURI_RS09830	COG0583	DNA-binding transcription factor activity
CURI_RS09870	COG1921	L-seryl-tRNASec selenium transferase activity
CURI_RS09875	COG0709	Synthesizes selenophosphate from selenide and ATP
CURI_RS09880	COG1555	photosystem II stabilization
CURI_RS09880	COG1596	polysaccharide export
CURI_RS09885	COG1686	Belongs to the peptidase S11 family
CURI_RS09890	COG0251	oxidation-reduction process
CURI_RS09895	COG0799	negative regulation of ribosome biogenesis
CURI_RS09900	COG1316	TRANSCRIPTIONal
CURI_RS09905	COG1713	HD superfamily hydrolase involved in NAD metabolism
CURI_RS09910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CURI_RS09920	COG1534	Rna-binding protein
CURI_RS09925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CURI_RS09935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CURI_RS09940	COG2868	ribosomal protein
CURI_RS09945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CURI_RS09950	COG1530	ribonuclease E activity
CURI_RS09970	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CURI_RS09975	COG2894	cell division
CURI_RS09980	COG0850	regulation of cytokinetic process
CURI_RS09985	COG0697	spore germination
CURI_RS09995	COG1136	(ABC) transporter
CURI_RS09995	COG0577	efflux transmembrane transporter activity
CURI_RS10030	COG1151	hydroxylamine reductase activity
CURI_RS10050	COG2195	Cleaves the N-terminal amino acid of tripeptides
CURI_RS10065	COG1686	Belongs to the peptidase S11 family
CURI_RS10070	COG0348	domain, Protein
CURI_RS10070	COG3901	Regulator of nitric oxide reductase transcription
CURI_RS10080	COG1686	Belongs to the peptidase S11 family
CURI_RS10095	COG1971	Probably functions as a manganese efflux pump
CURI_RS10115	COG0824	Thioesterase
CURI_RS10125	COG0205	6-phosphofructokinase activity
CURI_RS10135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CURI_RS10140	COG1481	regulation of sporulation
CURI_RS10150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CURI_RS10160	COG1796	DNA polymerase
CURI_RS10160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CURI_RS10175	COG0840	transmembrane signaling receptor activity
CURI_RS10180	COG0840	transmembrane signaling receptor activity
CURI_RS10185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CURI_RS10185	COG1013	pyruvate-flavodoxin oxidoreductase activity
CURI_RS10185	COG0674	pyruvate-flavodoxin oxidoreductase activity
CURI_RS10185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CURI_RS10190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CURI_RS10195	COG0322	excinuclease ABC activity
CURI_RS10225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CURI_RS10230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CURI_RS10240	COG2205	protein histidine kinase activity
CURI_RS10250	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CURI_RS10285	COG0556	nucleotide-excision repair
CURI_RS10300	COG3409	Peptidoglycan-binding domain 1 protein
CURI_RS10300	COG0793	Belongs to the peptidase S41A family
CURI_RS10305	COG0739	heme binding
CURI_RS10310	COG2177	Part of the ABC transporter FtsEX involved in
CURI_RS10315	COG2884	Cell division ATP-binding protein ftsE
CURI_RS10325	COG0745	RESPONSE REGULATOR receiver
CURI_RS10330	COG2205	protein histidine kinase activity
CURI_RS10360	COG5002	protein histidine kinase activity
CURI_RS10365	COG0745	RESPONSE REGULATOR receiver
CURI_RS10370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CURI_RS10375	COG1067	ATP-dependent peptidase activity
CURI_RS10385	COG3958	Transketolase
CURI_RS10390	COG3959	Transketolase, thiamine diphosphate binding domain
CURI_RS10395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CURI_RS10415	COG2337	Toxic component of a toxin-antitoxin (TA) module
CURI_RS10425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CURI_RS10435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CURI_RS10435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CURI_RS10445	COG0174	glutamine synthetase
CURI_RS10450	COG1785	Belongs to the alkaline phosphatase family
CURI_RS10510	COG0840	transmembrane signaling receptor activity
CURI_RS10515	COG0745	RESPONSE REGULATOR receiver
CURI_RS10515	COG2972	Histidine kinase
CURI_RS10520	COG0675	Transposase, IS605 OrfB family
CURI_RS10525	COG3279	Response regulator of the LytR AlgR family
CURI_RS10530	COG2972	Histidine kinase
CURI_RS10530	COG0745	RESPONSE REGULATOR receiver
CURI_RS10535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CURI_RS10540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CURI_RS10545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CURI_RS10550	COG0302	gtp cyclohydrolase
CURI_RS10560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CURI_RS10570	COG0512	Glutamine amidotransferase of anthranilate synthase
CURI_RS10585	COG1136	(ABC) transporter
CURI_RS10605	COG0534	Mate efflux family protein
CURI_RS10620	COG3655	Transcriptional regulator
CURI_RS10635	COG2814	Major facilitator Superfamily
CURI_RS10645	COG0495	leucyl-tRNA aminoacylation
CURI_RS10650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CURI_RS10660	COG1131	(ABC) transporter
CURI_RS10665	COG1725	Transcriptional regulator
CURI_RS10675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CURI_RS10675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CURI_RS10675	COG1013	pyruvate-flavodoxin oxidoreductase activity
CURI_RS10675	COG0674	pyruvate-flavodoxin oxidoreductase activity
CURI_RS10685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CURI_RS10690	COG0646	methionine synthase
CURI_RS10690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CURI_RS10695	COG1193	negative regulation of DNA recombination
CURI_RS10700	COG0583	DNA-binding transcription factor activity
CURI_RS10720	COG5002	protein histidine kinase activity
CURI_RS10725	COG0745	RESPONSE REGULATOR receiver
CURI_RS10730	COG0840	transmembrane signaling receptor activity
CURI_RS10745	COG2239	Acts as a magnesium transporter
CURI_RS10760	COG1388	LysM domain
CURI_RS10760	COG1705	Flagellar rod assembly protein muramidase FlgJ
CURI_RS10765	COG4124	Belongs to the glycosyl hydrolase 26 family
CURI_RS10765	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CURI_RS10770	COG0598	Magnesium transport protein CorA
CURI_RS10775	COG1464	Belongs to the NlpA lipoprotein family
CURI_RS10780	COG2011	ABC-type metal ion transport system permease component
CURI_RS10785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CURI_RS10790	COG2873	o-acetylhomoserine
CURI_RS10795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CURI_RS10805	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CURI_RS10810	COG0535	radical SAM domain protein
CURI_RS10810	COG1433	Dinitrogenase iron-molybdenum cofactor
CURI_RS10815	COG1433	Dinitrogenase iron-molybdenum cofactor
CURI_RS10815	COG0535	radical SAM domain protein
CURI_RS10855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CURI_RS10860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CURI_RS10875	COG1984	allophanate hydrolase subunit 2
CURI_RS10880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CURI_RS10890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CURI_RS10905	COG2199	diguanylate cyclase activity
CURI_RS10915	COG1253	flavin adenine dinucleotide binding
CURI_RS10920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CURI_RS10945	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CURI_RS10950	COG2339	peptidase activity
CURI_RS10955	COG1592	Rubrerythrin
CURI_RS10970	COG3546	catalase activity
CURI_RS10990	COG3409	Peptidoglycan-binding domain 1 protein
CURI_RS10990	COG5632	N-Acetylmuramoyl-L-alanine amidase
CURI_RS11090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CURI_RS11095	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CURI_RS11100	COG1321	iron dependent repressor
CURI_RS11115	COG0840	transmembrane signaling receptor activity
CURI_RS11135	COG0860	N-Acetylmuramoyl-L-alanine amidase
CURI_RS11145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CURI_RS11150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CURI_RS11155	COG0101	tRNA pseudouridine synthase activity
CURI_RS11160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CURI_RS11175	COG0203	ribosomal protein L17
CURI_RS11180	COG0202	RNA polymerase activity
CURI_RS11185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CURI_RS11190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CURI_RS11195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CURI_RS11200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CURI_RS11205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CURI_RS11215	COG0024	Methionine aminopeptidase
CURI_RS11220	COG0563	adenylate kinase activity
CURI_RS11225	COG0201	protein transport
CURI_RS11235	COG1841	ribosomal large subunit assembly
CURI_RS11240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CURI_RS11245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CURI_RS11250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CURI_RS11255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CURI_RS11265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CURI_RS11270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CURI_RS11280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CURI_RS11285	COG0255	Belongs to the universal ribosomal protein uL29 family
CURI_RS11290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CURI_RS11295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CURI_RS11300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CURI_RS11305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CURI_RS11310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CURI_RS11315	COG0089	rRNA binding
CURI_RS11320	COG0088	Forms part of the polypeptide exit tunnel
CURI_RS11325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CURI_RS11330	COG0051	transcription antitermination factor activity, RNA binding
CURI_RS11335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CURI_RS11340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CURI_RS11345	COG0049	tRNA binding
CURI_RS11350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CURI_RS11355	COG1358	cellular component organization or biogenesis
CURI_RS11360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CURI_RS11365	COG0085	RNA polymerase activity
CURI_RS11370	COG0222	ribosome binding
CURI_RS11375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CURI_RS11380	COG0081	regulation of translation
CURI_RS11390	COG0250	Participates in transcription elongation, termination and antitermination
CURI_RS11395	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CURI_RS11405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CURI_RS11425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CURI_RS11445	COG1045	serine acetyltransferase
CURI_RS11450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CURI_RS11455	COG4086	secreted protein
CURI_RS11460	COG0442	prolyl-tRNA aminoacylation
CURI_RS11470	COG3850	Histidine kinase
CURI_RS11470	COG5002	protein histidine kinase activity
CURI_RS11485	COG1131	(ABC) transporter
CURI_RS11490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CURI_RS11520	COG2824	Alkylphosphonate utilization operon protein PhnA
CURI_RS11535	COG0670	Belongs to the BI1 family
CURI_RS11545	COG0675	Transposase, IS605 OrfB family
CURI_RS11560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CURI_RS11565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CURI_RS11570	COG4956	integral membrane protein (PIN domain superfamily)
CURI_RS11575	COG1329	Transcriptional regulator
CURI_RS11590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CURI_RS11595	COG0542	response to heat
CURI_RS11600	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CURI_RS11605	COG3880	PFAM UvrB UvrC protein
CURI_RS11615	COG0436	Aminotransferase
CURI_RS11620	COG4894	glucomannan catabolic process
CURI_RS11630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CURI_RS11635	COG0505	Belongs to the CarA family
CURI_RS11650	COG1902	pentaerythritol trinitrate reductase activity
CURI_RS11655	COG1733	regulation of RNA biosynthetic process
CURI_RS11665	COG5002	protein histidine kinase activity
CURI_RS11670	COG0745	RESPONSE REGULATOR receiver
CURI_RS11685	COG0542	response to heat
CURI_RS11705	COG0693	protein deglycase activity
CURI_RS11715	COG1695	Transcriptional regulator
CURI_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
CURI_RS11760	COG1115	amino acid carrier protein
CURI_RS11765	COG1115	amino acid carrier protein
CURI_RS11800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CURI_RS11805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CURI_RS11815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CURI_RS11820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CURI_RS11835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CURI_RS11840	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CURI_RS11845	COG0037	tRNA processing
CURI_RS11850	COG0515	serine threonine protein kinase
CURI_RS11855	COG2304	oxidoreductase activity
CURI_RS11860	COG2208	phosphoserine phosphatase activity
CURI_RS11865	COG1098	S1 RNA binding domain
CURI_RS11885	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CURI_RS11890	COG0776	regulation of translation
CURI_RS11895	COG3956	TIGRFAM MazG family protein
CURI_RS11900	COG0728	peptidoglycan biosynthetic process
CURI_RS11905	COG2002	toxin-antitoxin pair type II binding
CURI_RS11910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CURI_RS11915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CURI_RS11920	COG0193	aminoacyl-tRNA hydrolase activity
CURI_RS11925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CURI_RS11930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CURI_RS11935	COG2088	sporulation resulting in formation of a cellular spore
CURI_RS11940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CURI_RS11945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CURI_RS11960	COG2080	2 iron, 2 sulfur cluster binding
CURI_RS11960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CURI_RS11975	COG0825	malonyl-CoA metabolic process
CURI_RS11980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CURI_RS11985	COG0439	Biotin carboxylase
CURI_RS11990	COG0511	ligase activity, forming carbon-carbon bonds
CURI_RS12025	COG2033	superoxide reductase activity
CURI_RS12035	COG1846	Transcriptional regulator
CURI_RS12040	COG0534	Mate efflux family protein
CURI_RS12055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CURI_RS12060	COG0622	Phosphoesterase
CURI_RS12095	COG3314	Sporulation integral membrane protein YlbJ
CURI_RS12100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CURI_RS12105	COG0488	(ABC) transporter
CURI_RS12110	COG5001	Diguanylate cyclase
CURI_RS12115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CURI_RS12130	COG2996	Protein conserved in bacteria
CURI_RS12160	COG0288	reversible hydration of carbon dioxide
CURI_RS12165	COG1592	Rubrerythrin
CURI_RS12165	COG1773	rubredoxin
CURI_RS12175	COG5278	phosphoserine phosphatase activity
CURI_RS12175	COG0840	transmembrane signaling receptor activity
CURI_RS12185	COG0840	transmembrane signaling receptor activity
CURI_RS12195	COG0395	ABC-type sugar transport system, permease component
CURI_RS12200	COG1175	transmembrane transport
CURI_RS12205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CURI_RS12210	COG1126	abc transporter atp-binding protein
CURI_RS12215	COG0765	amino acid transport
CURI_RS12220	COG0765	amino acid transport
CURI_RS12230	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CURI_RS12235	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CURI_RS12245	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CURI_RS12255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CURI_RS12255	COG0617	tRNA 3'-terminal CCA addition
CURI_RS12255	COG0517	IMP dehydrogenase activity
CURI_RS12260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CURI_RS12275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CURI_RS12280	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CURI_RS12290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CURI_RS12295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS12300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CURI_RS12305	COG1120	ATPase activity
CURI_RS12310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CURI_RS12320	COG0113	porphobilinogen synthase activity
CURI_RS12330	COG0181	hydroxymethylbilane synthase activity
CURI_RS12405	COG4974	Belongs to the 'phage' integrase family
CURI_RS12440	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CURI_RS12490	COG5002	protein histidine kinase activity
CURI_RS12495	COG0745	RESPONSE REGULATOR receiver
CURI_RS12515	COG2414	aldehyde ferredoxin oxidoreductase
CURI_RS12525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CURI_RS12530	COG0840	transmembrane signaling receptor activity
CURI_RS12540	COG0438	transferase activity, transferring glycosyl groups
CURI_RS12580	COG0772	Belongs to the SEDS family
CURI_RS12595	COG0175	sulfate reduction
CURI_RS12600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CURI_RS12605	COG1116	anion transmembrane transporter activity
CURI_RS12625	COG0529	Catalyzes the synthesis of activated sulfate
CURI_RS12630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CURI_RS12645	COG0840	transmembrane signaling receptor activity
CURI_RS12645	COG3290	protein histidine kinase activity
CURI_RS12650	COG0426	domain, Protein
CURI_RS12655	COG1410	methionine synthase
CURI_RS12655	COG0646	methionine synthase
CURI_RS12665	COG2201	protein-glutamate methylesterase activity
CURI_RS12675	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CURI_RS12700	COG0446	pyridine nucleotide-disulphide oxidoreductase
CURI_RS12710	COG0860	N-Acetylmuramoyl-L-alanine amidase
CURI_RS12715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CURI_RS12715	COG0646	methionine synthase
CURI_RS12720	COG0564	pseudouridine synthase activity
CURI_RS12725	COG1120	ATPase activity
CURI_RS12730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CURI_RS12735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CURI_RS12745	COG0037	tRNA processing
CURI_RS12755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CURI_RS12760	COG0156	8-amino-7-oxononanoate synthase activity
CURI_RS12775	COG1067	ATP-dependent peptidase activity
CURI_RS12815	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CURI_RS12825	COG1126	abc transporter atp-binding protein
CURI_RS12870	COG0726	polysaccharide deacetylase
CURI_RS12870	COG1649	PFAM Uncharacterised BCR, COG1649
CURI_RS12895	COG1136	(ABC) transporter
CURI_RS12900	COG2205	protein histidine kinase activity
CURI_RS12915	COG1595	DNA-templated transcription, initiation
CURI_RS12920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CURI_RS12925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CURI_RS12945	COG0840	transmembrane signaling receptor activity
CURI_RS12950	COG1309	transcriptional regulator
CURI_RS12985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CURI_RS12985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CURI_RS12990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CURI_RS13005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CURI_RS13010	COG0602	queuosine metabolic process
CURI_RS13015	COG0720	synthase
CURI_RS13020	COG1924	4 iron, 4 sulfur cluster binding
CURI_RS13035	COG0116	Belongs to the methyltransferase superfamily
CURI_RS13040	COG5002	protein histidine kinase activity
CURI_RS13045	COG0745	RESPONSE REGULATOR receiver
CURI_RS13055	COG1131	(ABC) transporter
CURI_RS13065	COG0513	Belongs to the DEAD box helicase family
CURI_RS13075	COG0840	transmembrane signaling receptor activity
CURI_RS13095	COG1131	(ABC) transporter
CURI_RS13100	COG2197	response regulator
CURI_RS13105	COG4585	Histidine kinase
CURI_RS13115	COG1473	amidohydrolase
CURI_RS13120	COG5002	protein histidine kinase activity
CURI_RS13130	COG4208	sulfate ABC transporter
CURI_RS13135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CURI_RS13140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CURI_RS13145	COG4977	sequence-specific DNA binding
CURI_RS13155	COG5002	protein histidine kinase activity
CURI_RS13160	COG0514	ATP-dependent DNA helicase (RecQ)
CURI_RS13185	COG0398	Pfam SNARE associated Golgi protein
CURI_RS13195	COG0398	Pfam SNARE associated Golgi protein
CURI_RS13205	COG2897	thiosulfate sulfurtransferase activity
CURI_RS13210	COG1979	alcohol dehydrogenase
CURI_RS13215	COG1113	amino acid transport
CURI_RS13220	COG5002	protein histidine kinase activity
CURI_RS13235	COG1396	sequence-specific DNA binding
CURI_RS13250	COG0697	spore germination
CURI_RS13280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CURI_RS13285	COG2364	Membrane
CURI_RS13300	COG0488	(ABC) transporter
CURI_RS13340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CURI_RS13350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CURI_RS13350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CURI_RS13375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CURI_RS13405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CURI_RS13415	COG0737	Belongs to the 5'-nucleotidase family
CURI_RS13430	COG1063	alcohol dehydrogenase
CURI_RS13455	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CURI_RS13470	COG1191	sigma factor activity
CURI_RS13485	COG0488	(ABC) transporter
CURI_RS13490	COG0577	efflux transmembrane transporter activity
CURI_RS13495	COG1136	(ABC) transporter
CURI_RS13500	COG2205	protein histidine kinase activity
CURI_RS13505	COG0745	RESPONSE REGULATOR receiver
CURI_RS13510	COG0586	Pfam SNARE associated Golgi protein
CURI_RS13530	COG2205	protein histidine kinase activity
CURI_RS13545	COG0745	RESPONSE REGULATOR receiver
CURI_RS13590	COG0436	Aminotransferase
CURI_RS13595	COG1522	sequence-specific DNA binding
CURI_RS13600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CURI_RS13610	COG0785	Cytochrome C biogenesis protein
CURI_RS13615	COG2205	protein histidine kinase activity
CURI_RS13620	COG0745	RESPONSE REGULATOR receiver
CURI_RS13635	COG0583	DNA-binding transcription factor activity
CURI_RS13640	COG0534	Mate efflux family protein
CURI_RS13645	COG0840	transmembrane signaling receptor activity
CURI_RS13665	COG5002	protein histidine kinase activity
CURI_RS13680	COG2832	Protein of unknown function (DUF454)
CURI_RS13690	COG1846	Transcriptional regulator
CURI_RS13705	COG3292	Two component regulator propeller
CURI_RS13705	COG2205	protein histidine kinase activity
CURI_RS13705	COG0745	RESPONSE REGULATOR receiver
CURI_RS13710	COG0745	RESPONSE REGULATOR receiver
CURI_RS13760	COG1131	(ABC) transporter
CURI_RS13775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CURI_RS13780	COG1733	regulation of RNA biosynthetic process
CURI_RS13790	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CURI_RS13810	COG0697	spore germination
CURI_RS13830	COG3655	Transcriptional regulator
CURI_RS13850	COG2207	Transcriptional regulator
CURI_RS13865	COG0778	Nitroreductase
CURI_RS13870	COG1242	4 iron, 4 sulfur cluster binding
CURI_RS13890	COG0840	transmembrane signaling receptor activity
CURI_RS13910	COG0860	N-Acetylmuramoyl-L-alanine amidase
CURI_RS13920	COG5002	protein histidine kinase activity
CURI_RS13945	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CURI_RS13955	COG2814	Major facilitator Superfamily
CURI_RS14000	COG0124	histidyl-tRNA synthetase
CURI_RS14005	COG3973	AAA domain
CURI_RS14015	COG0038	chloride channel
CURI_RS14020	COG0322	excinuclease ABC activity
CURI_RS14025	COG1335	isochorismatase
CURI_RS14035	COG0583	DNA-binding transcription factor activity
CURI_RS14050	COG1595	DNA-templated transcription, initiation
CURI_RS14055	COG4975	Glucose uptake
CURI_RS14085	COG4268	DNA restriction-modification system
CURI_RS14090	COG1401	restriction endodeoxyribonuclease activity
CURI_RS14110	COG1396	sequence-specific DNA binding
CURI_RS14130	COG0732	type I restriction modification DNA specificity domain
CURI_RS14135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CURI_RS14140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CURI_RS14145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CURI_RS14170	COG5002	protein histidine kinase activity
CURI_RS14185	COG1404	Belongs to the peptidase S8 family
CURI_RS14195	COG0534	Mate efflux family protein
CURI_RS14210	COG0739	heme binding
CURI_RS14260	COG0305	Participates in initiation and elongation during chromosome replication
CURI_RS14270	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CURI_RS14285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CURI_RS14290	COG0629	single-stranded DNA binding
CURI_RS14295	COG0360	Binds together with S18 to 16S ribosomal RNA
CURI_RS14305	COG0668	transmembrane transport
CURI_RS14325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CURI_RS14335	COG3949	Membrane
CURI_RS14340	COG1396	sequence-specific DNA binding
CURI_RS14450	COG0538	isocitrate dehydrogenase activity
CURI_RS14490	COG1104	cysteine desulfurase activity
CURI_RS14500	COG3608	succinylglutamate desuccinylase aspartoacylase
CURI_RS14500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CURI_RS14505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CURI_RS14515	COG1546	Belongs to the CinA family
CURI_RS14515	COG1058	Belongs to the CinA family
CURI_RS14520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CURI_RS14555	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CURI_RS14560	COG0163	prenyltransferase activity
CURI_RS14565	COG1335	isochorismatase
CURI_RS14575	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CURI_RS14580	COG3835	regulator
CURI_RS14585	COG3404	Formiminotransferase-cyclodeaminase
CURI_RS14605	COG2116	formate transmembrane transporter activity
CURI_RS14610	COG0840	transmembrane signaling receptor activity
CURI_RS14645	COG0303	'Molybdopterin
CURI_RS14655	COG0303	'Molybdopterin
CURI_RS14675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CURI_RS14685	COG0521	Mo-molybdopterin cofactor biosynthetic process
CURI_RS14695	COG3383	formate dehydrogenase (NAD+) activity
CURI_RS14700	COG3383	formate dehydrogenase (NAD+) activity
CURI_RS14725	COG0384	phenazine biosynthesis protein PhzF
CURI_RS14730	COG1475	DNA binding
CURI_RS14740	COG0357	Ribosomal RNA small subunit methyltransferase G
CURI_RS14755	COG1309	transcriptional regulator
CURI_RS14760	COG0071	Belongs to the small heat shock protein (HSP20) family
CURI_RS14775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CURI_RS14785	COG1847	R3H domain protein
CURI_RS14790	COG0706	membrane insertase activity
CURI_RS14795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CURI_RS14800	COG0594	ribonuclease P activity
CURI_RS14805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CURI_RS14810	COG1368	sulfuric ester hydrolase activity
CURI_RS14825	COG0592	DNA-directed DNA polymerase activity
CURI_RS14835	COG2207	Transcriptional regulator
CURI_RS14865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CURI_RS14885	COG0860	N-Acetylmuramoyl-L-alanine amidase
CURI_RS14900	COG1115	amino acid carrier protein
CURI_RS14920	COG0726	polysaccharide deacetylase
CURI_RS14930	COG2165	general secretion pathway protein
CURI_RS14935	COG3290	protein histidine kinase activity
CURI_RS14970	COG0768	penicillin binding
CURI_RS14980	COG3800	Transcriptional regulator
CURI_RS14980	COG1396	sequence-specific DNA binding
CURI_RS15040	COG0860	N-Acetylmuramoyl-L-alanine amidase
CURI_RS15045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CURI_RS15050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CURI_RS15055	COG1131	(ABC) transporter
CURI_RS15070	COG0860	N-Acetylmuramoyl-L-alanine amidase
CURI_RS15075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CURI_RS15085	COG0671	phosphoesterase, PA-phosphatase related
CURI_RS15100	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CURI_RS15105	COG1376	ErfK ybiS ycfS ynhG family protein
CURI_RS15110	COG1376	ErfK ybiS ycfS ynhG family protein
CURI_RS15140	COG1595	DNA-templated transcription, initiation