locus-tag	class	description
CBC4_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CBC4_RS00010	COG0594	ribonuclease P activity
CBC4_RS00015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CBC4_RS00025	COG1847	R3H domain protein
CBC4_RS00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CBC4_RS00035	COG0445	tRNA wobble uridine modification
CBC4_RS00040	COG0357	Ribosomal RNA small subunit methyltransferase G
CBC4_RS00050	COG1192	Involved in chromosome partitioning
CBC4_RS00055	COG1475	DNA binding
CBC4_RS00080	COG0360	Binds together with S18 to 16S ribosomal RNA
CBC4_RS00085	COG0629	single-stranded DNA binding
CBC4_RS00090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CBC4_RS00105	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CBC4_RS00110	COG0359	binds to the 23S rRNA
CBC4_RS00115	COG0470	DNA polymerase III
CBC4_RS00115	COG1067	ATP-dependent peptidase activity
CBC4_RS00120	COG0305	Participates in initiation and elongation during chromosome replication
CBC4_RS00125	COG0071	Belongs to the small heat shock protein (HSP20) family
CBC4_RS00135	COG1307	EDD domain protein, DegV family
CBC4_RS00145	COG0460	homoserine dehydrogenase
CBC4_RS00155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CBC4_RS00155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CBC4_RS00165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CBC4_RS00170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CBC4_RS00175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CBC4_RS00180	COG0492	ferredoxin-NADP+ reductase activity
CBC4_RS00185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CBC4_RS00200	COG2081	HI0933 family
CBC4_RS00260	COG1846	Transcriptional regulator
CBC4_RS00265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBC4_RS00270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBC4_RS00280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CBC4_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
CBC4_RS00290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBC4_RS00295	COG0511	ligase activity, forming carbon-carbon bonds
CBC4_RS00300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBC4_RS00305	COG0439	Biotin carboxylase
CBC4_RS00310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CBC4_RS00315	COG0825	malonyl-CoA metabolic process
CBC4_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBC4_RS00325	COG0765	amino acid transport
CBC4_RS00330	COG1126	abc transporter atp-binding protein
CBC4_RS00350	COG1058	Belongs to the CinA family
CBC4_RS00350	COG1546	Belongs to the CinA family
CBC4_RS00360	COG1404	Belongs to the peptidase S8 family
CBC4_RS00385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CBC4_RS00395	COG0653	protein targeting
CBC4_RS00405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CBC4_RS00410	COG5002	protein histidine kinase activity
CBC4_RS00410	COG3850	Histidine kinase
CBC4_RS00420	COG0745	RESPONSE REGULATOR receiver
CBC4_RS00425	COG0367	asparagine synthase
CBC4_RS00440	COG0840	transmembrane signaling receptor activity
CBC4_RS00445	COG2824	Alkylphosphonate utilization operon protein PhnA
CBC4_RS00455	COG3842	ATPase activity
CBC4_RS00485	COG0058	SHG alpha-glucan phosphorylase activity
CBC4_RS00520	COG0577	efflux transmembrane transporter activity
CBC4_RS00520	COG1136	(ABC) transporter
CBC4_RS00525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CBC4_RS00545	COG1266	CAAX protease self-immunity
CBC4_RS00550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBC4_RS00570	COG3835	regulator
CBC4_RS00575	COG2610	gluconate transmembrane transporter activity
CBC4_RS00585	COG1929	Belongs to the glycerate kinase type-1 family
CBC4_RS00600	COG3546	catalase activity
CBC4_RS00660	COG0513	Belongs to the DEAD box helicase family
CBC4_RS00665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CBC4_RS00670	COG0840	transmembrane signaling receptor activity
CBC4_RS00680	COG3949	Membrane
CBC4_RS00695	COG1242	4 iron, 4 sulfur cluster binding
CBC4_RS00700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CBC4_RS00705	COG0671	phosphoesterase, PA-phosphatase related
CBC4_RS00730	COG1121	(ABC) transporter
CBC4_RS00735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBC4_RS00740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CBC4_RS00745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBC4_RS00750	COG2088	sporulation resulting in formation of a cellular spore
CBC4_RS00755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CBC4_RS00765	COG0745	RESPONSE REGULATOR receiver
CBC4_RS00770	COG5002	protein histidine kinase activity
CBC4_RS00770	COG3850	Histidine kinase
CBC4_RS00775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBC4_RS00780	COG0193	aminoacyl-tRNA hydrolase activity
CBC4_RS00785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CBC4_RS00790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CBC4_RS00795	COG2002	toxin-antitoxin pair type II binding
CBC4_RS00800	COG2244	polysaccharide biosynthetic process
CBC4_RS00805	COG3956	TIGRFAM MazG family protein
CBC4_RS00815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CBC4_RS00835	COG1098	S1 RNA binding domain
CBC4_RS00880	COG2208	phosphoserine phosphatase activity
CBC4_RS00895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBC4_RS00905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CBC4_RS00910	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CBC4_RS00915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CBC4_RS00920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CBC4_RS00925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CBC4_RS00940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CBC4_RS00975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBC4_RS00980	COG1592	Rubrerythrin
CBC4_RS00995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CBC4_RS01020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CBC4_RS01025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CBC4_RS01040	COG1328	CTP reductase activity
CBC4_RS01055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBC4_RS01060	COG2211	Major facilitator Superfamily
CBC4_RS01070	COG3191	aminopeptidase activity
CBC4_RS01075	COG1592	Rubrerythrin
CBC4_RS01075	COG1773	rubredoxin
CBC4_RS01090	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CBC4_RS01095	COG0542	response to heat
CBC4_RS01100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CBC4_RS01105	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CBC4_RS01115	COG4956	integral membrane protein (PIN domain superfamily)
CBC4_RS01120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CBC4_RS01125	COG0215	cysteine-tRNA ligase activity
CBC4_RS01140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBC4_RS01160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CBC4_RS01175	COG0250	Participates in transcription elongation, termination and antitermination
CBC4_RS01180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CBC4_RS01185	COG0081	regulation of translation
CBC4_RS01195	COG0222	ribosome binding
CBC4_RS01200	COG0085	RNA polymerase activity
CBC4_RS01205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CBC4_RS01210	COG1358	cellular component organization or biogenesis
CBC4_RS01215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CBC4_RS01220	COG0049	tRNA binding
CBC4_RS01225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBC4_RS01230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CBC4_RS01235	COG0051	transcription antitermination factor activity, RNA binding
CBC4_RS01240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CBC4_RS01245	COG0088	Forms part of the polypeptide exit tunnel
CBC4_RS01250	COG0089	rRNA binding
CBC4_RS01255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CBC4_RS01260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CBC4_RS01265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CBC4_RS01270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CBC4_RS01275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CBC4_RS01280	COG0255	Belongs to the universal ribosomal protein uL29 family
CBC4_RS01285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CBC4_RS01290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CBC4_RS01295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CBC4_RS01300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CBC4_RS01305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CBC4_RS01310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CBC4_RS01315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CBC4_RS01320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CBC4_RS01325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CBC4_RS01330	COG1841	ribosomal large subunit assembly
CBC4_RS01335	COG0200	Binds to the 23S rRNA
CBC4_RS01340	COG0201	protein transport
CBC4_RS01345	COG0563	adenylate kinase activity
CBC4_RS01360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CBC4_RS01365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CBC4_RS01370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CBC4_RS01375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CBC4_RS01380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBC4_RS01385	COG0202	RNA polymerase activity
CBC4_RS01390	COG0203	ribosomal protein L17
CBC4_RS01395	COG1122	ATPase activity
CBC4_RS01400	COG1122	ATPase activity
CBC4_RS01405	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CBC4_RS01415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CBC4_RS01420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CBC4_RS01435	COG0704	Plays a role in the regulation of phosphate uptake
CBC4_RS01440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBC4_RS01455	COG3118	belongs to the thioredoxin family
CBC4_RS01460	COG0492	ferredoxin-NADP+ reductase activity
CBC4_RS01465	COG3773	Cell wall hydrolase
CBC4_RS01465	COG3409	Peptidoglycan-binding domain 1 protein
CBC4_RS01475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CBC4_RS01485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CBC4_RS01490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBC4_RS01500	COG1695	Transcriptional regulator
CBC4_RS01515	COG0745	RESPONSE REGULATOR receiver
CBC4_RS01520	COG5002	protein histidine kinase activity
CBC4_RS01535	COG0659	secondary active sulfate transmembrane transporter activity
CBC4_RS01540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CBC4_RS01545	COG0789	Transcriptional regulator
CBC4_RS01580	COG1131	(ABC) transporter
CBC4_RS01615	COG4591	ABC-type transport system involved in lipoprotein release permease component
CBC4_RS01615	COG1136	(ABC) transporter
CBC4_RS01620	COG0577	efflux transmembrane transporter activity
CBC4_RS01630	COG3850	Histidine kinase
CBC4_RS01630	COG5002	protein histidine kinase activity
CBC4_RS01635	COG1131	(ABC) transporter
CBC4_RS01665	COG1971	Probably functions as a manganese efflux pump
CBC4_RS01670	COG0840	transmembrane signaling receptor activity
CBC4_RS01675	COG0840	transmembrane signaling receptor activity
CBC4_RS01690	COG2217	Heavy metal translocating P-type atpase
CBC4_RS01695	COG1473	amidohydrolase
CBC4_RS01715	COG5002	protein histidine kinase activity
CBC4_RS01720	COG0586	Pfam SNARE associated Golgi protein
CBC4_RS01730	COG2707	UPF0756 membrane protein
CBC4_RS01735	COG0772	Belongs to the SEDS family
CBC4_RS01740	COG1695	Transcriptional regulator
CBC4_RS01745	COG2873	o-acetylhomoserine
CBC4_RS01750	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CBC4_RS01760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBC4_RS01765	COG3069	C4-dicarboxylate transmembrane transporter activity
CBC4_RS01775	COG2207	Transcriptional regulator
CBC4_RS01785	COG1882	Formate acetyltransferase
CBC4_RS01790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CBC4_RS01800	COG2339	peptidase activity
CBC4_RS01820	COG3842	ATPase activity
CBC4_RS01825	COG1176	ABC-type spermidine putrescine transport system, permease component I
CBC4_RS01830	COG1177	transmembrane transport
CBC4_RS01840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CBC4_RS01845	COG1609	Transcriptional regulator
CBC4_RS01860	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CBC4_RS01865	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CBC4_RS01875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBC4_RS01890	COG0017	Asparaginyl-tRNA synthetase
CBC4_RS01900	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CBC4_RS01905	COG1074	ATP-dependent DNA helicase activity
CBC4_RS01910	COG3481	metal-dependent phosphohydrolase, HD sub domain
CBC4_RS02000	COG0297	glycogen (starch) synthase activity
CBC4_RS02005	COG0058	SHG alpha-glucan phosphorylase activity
CBC4_RS02020	COG1141	Ferredoxin
CBC4_RS02040	COG3829	transcription factor binding
CBC4_RS02060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CBC4_RS02075	COG0420	3'-5' exonuclease activity
CBC4_RS02080	COG0419	ATPase involved in DNA repair
CBC4_RS02095	COG0840	transmembrane signaling receptor activity
CBC4_RS02100	COG1760	l-serine dehydratase
CBC4_RS02105	COG1760	l-serine dehydratase
CBC4_RS02115	COG3275	phosphorelay sensor kinase activity
CBC4_RS02120	COG3279	Response regulator of the LytR AlgR family
CBC4_RS02125	COG1966	Carbon starvation protein
CBC4_RS02140	COG0736	holo-[acyl-carrier-protein] synthase activity
CBC4_RS02145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CBC4_RS02145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CBC4_RS02155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CBC4_RS02170	COG3959	Transketolase, thiamine diphosphate binding domain
CBC4_RS02175	COG3958	Transketolase
CBC4_RS02180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBC4_RS02185	COG2884	Cell division ATP-binding protein ftsE
CBC4_RS02190	COG2177	Part of the ABC transporter FtsEX involved in
CBC4_RS02195	COG3409	Peptidoglycan-binding domain 1 protein
CBC4_RS02195	COG0793	Belongs to the peptidase S41A family
CBC4_RS02205	COG0556	nucleotide-excision repair
CBC4_RS02225	COG0768	penicillin binding
CBC4_RS02235	COG0322	excinuclease ABC activity
CBC4_RS02240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CBC4_RS02245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CBC4_RS02250	COG1660	Displays ATPase and GTPase activities
CBC4_RS02255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CBC4_RS02260	COG1481	regulation of sporulation
CBC4_RS02265	COG4109	DRTGG domain
CBC4_RS02270	COG2502	aspartate--ammonia ligase
CBC4_RS02275	COG0745	RESPONSE REGULATOR receiver
CBC4_RS02280	COG5002	protein histidine kinase activity
CBC4_RS02295	COG2271	Major facilitator Superfamily
CBC4_RS02310	COG0205	6-phosphofructokinase activity
CBC4_RS02315	COG0469	pyruvate kinase activity
CBC4_RS02325	COG2207	Transcriptional regulator
CBC4_RS02345	COG1131	(ABC) transporter
CBC4_RS02370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBC4_RS02375	COG0135	phosphoribosylanthranilate isomerase activity
CBC4_RS02380	COG1522	sequence-specific DNA binding
CBC4_RS02380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBC4_RS02385	COG1114	Component of the transport system for branched-chain amino acids
CBC4_RS02395	COG0710	3-dehydroquinate dehydratase activity
CBC4_RS02400	COG0456	acetyltransferase
CBC4_RS02400	COG1214	PFAM Peptidase M22, glycoprotease
CBC4_RS02405	COG0745	RESPONSE REGULATOR receiver
CBC4_RS02410	COG2205	protein histidine kinase activity
CBC4_RS02415	COG1136	(ABC) transporter
CBC4_RS02420	COG0577	efflux transmembrane transporter activity
CBC4_RS02435	COG2271	Major facilitator Superfamily
CBC4_RS02450	COG5002	protein histidine kinase activity
CBC4_RS02455	COG0745	RESPONSE REGULATOR receiver
CBC4_RS02470	COG3428	Bacterial PH domain
CBC4_RS02475	COG0745	RESPONSE REGULATOR receiver
CBC4_RS02480	COG5002	protein histidine kinase activity
CBC4_RS02490	COG0076	glutamate decarboxylase activity
CBC4_RS02515	COG1960	acyl-CoA dehydrogenase activity
CBC4_RS02520	COG0726	polysaccharide deacetylase
CBC4_RS02525	COG0310	cobalt ion transport
CBC4_RS02535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CBC4_RS02540	COG1122	ATPase activity
CBC4_RS02545	COG0840	transmembrane signaling receptor activity
CBC4_RS02550	COG0733	neurotransmitter:sodium symporter activity
CBC4_RS02565	COG1696	Membrane protein involved in D-alanine export
CBC4_RS02575	COG3773	Cell wall hydrolase
CBC4_RS02585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBC4_RS02590	COG3973	AAA domain
CBC4_RS02605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CBC4_RS02615	COG1362	aminopeptidase activity
CBC4_RS02650	COG0019	diaminopimelate decarboxylase activity
CBC4_RS02655	COG3459	Glycosyltransferase 36 associated
CBC4_RS02665	COG0561	phosphatase activity
CBC4_RS02670	COG0561	phosphatase activity
CBC4_RS02675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CBC4_RS02690	COG2199	diguanylate cyclase activity
CBC4_RS02690	COG2203	Gaf domain
CBC4_RS02710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CBC4_RS02725	COG2357	RelA SpoT domain protein
CBC4_RS02730	COG0495	leucyl-tRNA aminoacylation
CBC4_RS02735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CBC4_RS02735	COG0539	negative regulation of cytoplasmic translation
CBC4_RS02750	COG0484	heat shock protein binding
CBC4_RS02770	COG0191	fructose-bisphosphate aldolase activity
CBC4_RS02780	COG2323	membrane
CBC4_RS02785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBC4_RS02795	COG1183	phosphatidylcholine synthase activity
CBC4_RS02800	COG0517	IMP dehydrogenase activity
CBC4_RS02805	COG1597	lipid kinase activity
CBC4_RS02830	COG1045	serine acetyltransferase
CBC4_RS02835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CBC4_RS02840	COG2937	Belongs to the GPAT DAPAT family
CBC4_RS02845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBC4_RS02860	COG1363	Peptidase, m42
CBC4_RS02865	COG2720	vancomycin resistance protein
CBC4_RS02870	COG0561	phosphatase activity
CBC4_RS02880	COG1307	EDD domain protein, DegV family
CBC4_RS02885	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CBC4_RS02890	COG2390	Transcriptional regulator
CBC4_RS02895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CBC4_RS02900	COG1744	ABC transporter substrate-binding protein PnrA-like
CBC4_RS02905	COG3845	ABC transporter
CBC4_RS02910	COG4603	Belongs to the binding-protein-dependent transport system permease family
CBC4_RS02915	COG1079	Belongs to the binding-protein-dependent transport system permease family
CBC4_RS02920	COG0126	phosphoglycerate kinase activity
CBC4_RS02925	COG0149	triose-phosphate isomerase activity
CBC4_RS02930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CBC4_RS02935	COG0148	phosphopyruvate hydratase activity
CBC4_RS02940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CBC4_RS02950	COG0557	exoribonuclease II activity
CBC4_RS02955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CBC4_RS02965	COG2801	Transposase and inactivated derivatives
CBC4_RS02980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CBC4_RS02990	COG0745	RESPONSE REGULATOR receiver
CBC4_RS03020	COG2205	protein histidine kinase activity
CBC4_RS03025	COG1187	pseudouridine synthase activity
CBC4_RS03030	COG4106	trans-aconitate 2-methyltransferase activity
CBC4_RS03035	COG2267	carboxylic ester hydrolase activity
CBC4_RS03040	COG0156	8-amino-7-oxononanoate synthase activity
CBC4_RS03045	COG2132	Multicopper oxidase
CBC4_RS03055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CBC4_RS03060	COG3859	Proton-coupled thiamine transporter YuaJ
CBC4_RS03075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBC4_RS03105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBC4_RS03120	COG4988	ABC transporter
CBC4_RS03125	COG1132	(ABC) transporter
CBC4_RS03140	COG0443	Heat shock 70 kDa protein
CBC4_RS03150	COG0484	heat shock protein binding
CBC4_RS03155	COG1522	sequence-specific DNA binding
CBC4_RS03160	COG0436	Aminotransferase
CBC4_RS03195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CBC4_RS03200	COG0281	malic enzyme
CBC4_RS03205	COG1301	dicarboxylic acid transport
CBC4_RS03210	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CBC4_RS03215	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CBC4_RS03215	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CBC4_RS03220	COG1027	Aspartate ammonia-lyase
CBC4_RS03245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CBC4_RS03255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CBC4_RS03290	COG0363	glucosamine-6-phosphate deaminase activity
CBC4_RS03300	COG2188	Transcriptional regulator
CBC4_RS03305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CBC4_RS03315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CBC4_RS03345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CBC4_RS03380	COG1342	Belongs to the UPF0251 family
CBC4_RS03390	COG3773	Cell wall hydrolase
CBC4_RS03400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CBC4_RS03405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CBC4_RS03415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CBC4_RS03420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CBC4_RS03445	COG2022	thiamine diphosphate biosynthetic process
CBC4_RS03475	COG0392	lysyltransferase activity
CBC4_RS03475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CBC4_RS03480	COG3481	metal-dependent phosphohydrolase, HD sub domain
CBC4_RS03485	COG4536	flavin adenine dinucleotide binding
CBC4_RS03490	COG4536	flavin adenine dinucleotide binding
CBC4_RS03495	COG1388	LysM domain
CBC4_RS03495	COG3858	chitin binding
CBC4_RS03505	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CBC4_RS03510	COG0745	RESPONSE REGULATOR receiver
CBC4_RS03515	COG5002	protein histidine kinase activity
CBC4_RS03520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBC4_RS03525	COG1295	ribonuclease BN
CBC4_RS03550	COG1979	alcohol dehydrogenase
CBC4_RS03570	COG1136	(ABC) transporter
CBC4_RS03585	COG3944	biosynthesis protein
CBC4_RS03590	COG0489	protein tyrosine kinase activity
CBC4_RS03595	COG4464	protein tyrosine phosphatase activity
CBC4_RS03600	COG3475	LICD family
CBC4_RS03605	COG3475	LICD family
CBC4_RS03615	COG1063	alcohol dehydrogenase
CBC4_RS03650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CBC4_RS03670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CBC4_RS03685	COG0840	transmembrane signaling receptor activity
CBC4_RS03745	COG0840	transmembrane signaling receptor activity
CBC4_RS03750	COG1971	Probably functions as a manganese efflux pump
CBC4_RS03770	COG1164	Oligoendopeptidase f
CBC4_RS03780	COG0705	Rhomboid family
CBC4_RS03780	COG0457	Tetratricopeptide repeat
CBC4_RS03790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBC4_RS03815	COG3442	glutamine amidotransferase
CBC4_RS03820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CBC4_RS03835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBC4_RS03840	COG4656	Part of a membrane complex involved in electron transport
CBC4_RS03845	COG4658	electron transport chain
CBC4_RS03850	COG4659	FMN binding
CBC4_RS03855	COG4660	Part of a membrane complex involved in electron transport
CBC4_RS03860	COG4657	Part of a membrane complex involved in electron transport
CBC4_RS03865	COG2878	Part of a membrane complex involved in electron transport
CBC4_RS03865	COG1245	4Fe-4S binding domain
CBC4_RS03875	COG2239	Acts as a magnesium transporter
CBC4_RS03880	COG0840	transmembrane signaling receptor activity
CBC4_RS03890	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CBC4_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
CBC4_RS03900	COG0800	Aldolase
CBC4_RS03905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBC4_RS03910	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CBC4_RS03920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CBC4_RS03925	COG3715	PTS system
CBC4_RS03940	COG1609	Transcriptional regulator
CBC4_RS03950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CBC4_RS03950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CBC4_RS03955	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CBC4_RS03955	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBC4_RS03960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CBC4_RS03960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBC4_RS03965	COG3715	PTS system
CBC4_RS03970	COG3716	PTS system mannose fructose sorbose family IID component
CBC4_RS03975	COG1482	cell wall glycoprotein biosynthetic process
CBC4_RS04005	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CBC4_RS04010	COG2814	Major facilitator Superfamily
CBC4_RS04020	COG2186	Transcriptional regulator
CBC4_RS04025	COG1620	l-lactate permease
CBC4_RS04030	COG2086	electron transfer activity
CBC4_RS04035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBC4_RS04040	COG0277	FAD linked oxidase domain protein
CBC4_RS04050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CBC4_RS04055	COG0671	phosphoesterase, PA-phosphatase related
CBC4_RS04065	COG1376	ErfK ybiS ycfS ynhG family protein
CBC4_RS04070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBC4_RS04110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CBC4_RS04130	COG1473	amidohydrolase
CBC4_RS04140	COG2244	polysaccharide biosynthetic process
CBC4_RS04145	COG2244	polysaccharide biosynthetic process
CBC4_RS04150	COG1301	dicarboxylic acid transport
CBC4_RS04180	COG1269	ATP hydrolysis coupled proton transport
CBC4_RS04185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBC4_RS04190	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CBC4_RS04205	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CBC4_RS04210	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CBC4_RS04215	COG1394	ATPase activity, coupled to movement of substances
CBC4_RS04220	COG0242	peptide deformylase activity
CBC4_RS04235	COG0426	domain, Protein
CBC4_RS04245	COG1494	fructose-1,6-bisphosphatase
CBC4_RS04250	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CBC4_RS04255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CBC4_RS04260	COG0598	Magnesium transport protein CorA
CBC4_RS04265	COG1362	aminopeptidase activity
CBC4_RS04275	COG0613	PHP domain protein
CBC4_RS04315	COG1846	Transcriptional regulator
CBC4_RS04325	COG1266	CAAX protease self-immunity
CBC4_RS04335	COG1349	DNA-binding transcription factor activity
CBC4_RS04340	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CBC4_RS04350	COG3775	system Galactitol-specific IIC component
CBC4_RS04360	COG3647	Membrane
CBC4_RS04365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBC4_RS04365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBC4_RS04370	COG0237	dephospho-CoA kinase activity
CBC4_RS04375	COG0741	lytic transglycosylase activity
CBC4_RS04385	COG4492	Belongs to the UPF0735 family
CBC4_RS04410	COG0424	maF-like protein
CBC4_RS04415	COG2003	Belongs to the UPF0758 family
CBC4_RS04420	COG1077	Cell shape determining protein MreB Mrl
CBC4_RS04435	COG0768	penicillin binding
CBC4_RS04440	COG0850	regulation of cytokinetic process
CBC4_RS04445	COG2894	cell division
CBC4_RS04450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CBC4_RS04455	COG0772	Belongs to the SEDS family
CBC4_RS04460	COG1803	Methylglyoxal synthase
CBC4_RS04475	COG3344	reverse transcriptase
CBC4_RS04485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBC4_RS04515	COG0612	Peptidase, M16
CBC4_RS04535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CBC4_RS04540	COG1116	anion transmembrane transporter activity
CBC4_RS04550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CBC4_RS04555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CBC4_RS04575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CBC4_RS04585	COG1105	Belongs to the carbohydrate kinase PfkB family
CBC4_RS04615	COG0628	permease
CBC4_RS04620	COG2094	Belongs to the DNA glycosylase MPG family
CBC4_RS04650	COG2171	N-acyltransferase activity
CBC4_RS04655	COG0436	Aminotransferase
CBC4_RS04665	COG0601	transmembrane transport
CBC4_RS04670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBC4_RS04675	COG0444	Belongs to the ABC transporter superfamily
CBC4_RS04680	COG4608	Belongs to the ABC transporter superfamily
CBC4_RS04690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CBC4_RS04695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CBC4_RS04700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CBC4_RS04710	COG2226	methyltransferase
CBC4_RS04715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CBC4_RS04775	COG3716	PTS system mannose fructose sorbose family IID component
CBC4_RS04780	COG3715	PTS system
CBC4_RS04810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBC4_RS04820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CBC4_RS04825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CBC4_RS04830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBC4_RS04835	COG0569	domain protein
CBC4_RS04840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBC4_RS04845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CBC4_RS04940	COG2032	superoxide dismutase activity
CBC4_RS04945	COG0826	peptidase U32
CBC4_RS04950	COG1193	negative regulation of DNA recombination
CBC4_RS04955	COG1683	Conserved Protein
CBC4_RS04960	COG1131	(ABC) transporter
CBC4_RS04980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CBC4_RS04985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBC4_RS04995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CBC4_RS05020	COG1083	cytidylyl-transferase
CBC4_RS05025	COG2089	acid synthase
CBC4_RS05030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBC4_RS05040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBC4_RS05045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBC4_RS05050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CBC4_RS05075	COG0438	transferase activity, transferring glycosyl groups
CBC4_RS05085	COG1215	transferase activity, transferring glycosyl groups
CBC4_RS05095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CBC4_RS05100	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CBC4_RS05110	COG0438	transferase activity, transferring glycosyl groups
CBC4_RS05115	COG0778	Nitroreductase
CBC4_RS05125	COG0827	DNA restriction-modification system
CBC4_RS05135	COG2172	sigma factor antagonist activity
CBC4_RS05165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBC4_RS05175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBC4_RS05180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CBC4_RS05185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CBC4_RS05200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBC4_RS05210	COG1739	Uncharacterized protein family UPF0029
CBC4_RS05215	COG0217	transcriptional regulatory protein
CBC4_RS05250	COG2610	gluconate transmembrane transporter activity
CBC4_RS05260	COG1132	(ABC) transporter
CBC4_RS05275	COG3314	Sporulation integral membrane protein YlbJ
CBC4_RS05310	COG2255	four-way junction helicase activity
CBC4_RS05345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBC4_RS05350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBC4_RS05355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBC4_RS05355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBC4_RS05360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBC4_RS05365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CBC4_RS05370	COG1490	D-aminoacyl-tRNA deacylase activity
CBC4_RS05375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBC4_RS05380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBC4_RS05385	COG0124	histidyl-tRNA synthetase
CBC4_RS05390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CBC4_RS05395	COG1937	Protein conserved in bacteria
CBC4_RS05405	COG2966	Psort location CytoplasmicMembrane, score
CBC4_RS05410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CBC4_RS05420	COG3906	Belongs to the UPF0473 family
CBC4_RS05440	COG2190	(PTS) system
CBC4_RS05440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CBC4_RS05440	COG1263	PTS System
CBC4_RS05455	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CBC4_RS05460	COG2201	protein-glutamate methylesterase activity
CBC4_RS05465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CBC4_RS05470	COG0643	Histidine kinase
CBC4_RS05470	COG2198	Histidine kinase
CBC4_RS05475	COG1776	CheC inhibitor of MCP methylation
CBC4_RS05480	COG2201	protein-glutamate methylesterase activity
CBC4_RS05485	COG0835	chemotaxis
CBC4_RS05490	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBC4_RS05495	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBC4_RS05495	COG1776	CheC inhibitor of MCP methylation
CBC4_RS05510	COG1256	bacterial-type flagellum assembly
CBC4_RS05510	COG4786	Flagellar basal body rod
CBC4_RS05515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBC4_RS05520	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CBC4_RS05525	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CBC4_RS05540	COG1516	flagellar protein fliS
CBC4_RS05545	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CBC4_RS05560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBC4_RS05575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBC4_RS05580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBC4_RS05590	COG2089	acid synthase
CBC4_RS05615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBC4_RS05625	COG1213	nucleotidyl transferase
CBC4_RS05640	COG0697	spore germination
CBC4_RS05645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBC4_RS05650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBC4_RS05655	COG1815	bacterial-type flagellum-dependent cell motility
CBC4_RS05660	COG1558	bacterial-type flagellum-dependent cell motility
CBC4_RS05665	COG1677	Flagellar hook-basal body complex protein FliE
CBC4_RS05670	COG1766	The M ring may be actively involved in energy transduction
CBC4_RS05675	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBC4_RS05685	COG1157	protein secretion by the type III secretion system
CBC4_RS05700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CBC4_RS05715	COG1582	Flagellar protein (FlbD)
CBC4_RS05725	COG1360	Flagellar Motor Protein
CBC4_RS05730	COG1580	Controls the rotational direction of flagella during chemotaxis
CBC4_RS05740	COG1338	Plays a role in the flagellum-specific transport system
CBC4_RS05750	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CBC4_RS05755	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CBC4_RS05760	COG1419	protein localization to endoplasmic reticulum
CBC4_RS05765	COG0455	bacterial-type flagellum organization
CBC4_RS05775	COG1191	sigma factor activity
CBC4_RS05790	COG4786	Flagellar basal body rod
CBC4_RS05805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CBC4_RS05815	COG1067	ATP-dependent peptidase activity
CBC4_RS05820	COG0012	GTP binding
CBC4_RS05825	COG0275	rRNA processing
CBC4_RS05835	COG0768	penicillin binding
CBC4_RS05845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CBC4_RS05850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBC4_RS05855	COG0772	Belongs to the SEDS family
CBC4_RS05875	COG3879	Bacterial protein of unknown function (DUF881)
CBC4_RS05880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CBC4_RS05885	COG1799	cell septum assembly
CBC4_RS05895	COG2302	S4 RNA-binding domain
CBC4_RS05900	COG3599	regulation of cell shape
CBC4_RS05915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBC4_RS05920	COG0564	pseudouridine synthase activity
CBC4_RS05925	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CBC4_RS05940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CBC4_RS06000	COG3935	DnaD domain protein
CBC4_RS06005	COG1484	DNA-dependent DNA replication
CBC4_RS06060	COG1783	phage Terminase large subunit
CBC4_RS06070	COG2369	cell adhesion
CBC4_RS06170	COG2333	competence protein COMEC
CBC4_RS06170	COG0658	competence protein
CBC4_RS06175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CBC4_RS06180	COG1459	type II secretion system
CBC4_RS06230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CBC4_RS06240	COG3854	ATPases associated with a variety of cellular activities
CBC4_RS06280	COG1302	Protein conserved in bacteria
CBC4_RS06285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBC4_RS06290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CBC4_RS06295	COG1570	exodeoxyribonuclease VII activity
CBC4_RS06300	COG1722	exodeoxyribonuclease VII activity
CBC4_RS06310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CBC4_RS06315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CBC4_RS06320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CBC4_RS06325	COG1438	arginine binding
CBC4_RS06330	COG0497	DNA recombination
CBC4_RS06335	COG0750	zinc metalloprotease
CBC4_RS06340	COG0745	RESPONSE REGULATOR receiver
CBC4_RS06370	COG0494	nUDIX hydrolase
CBC4_RS06375	COG1300	Membrane
CBC4_RS06385	COG4974	Belongs to the 'phage' integrase family
CBC4_RS06390	COG1686	Belongs to the peptidase S11 family
CBC4_RS06405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CBC4_RS06410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CBC4_RS06415	COG3874	Sporulation protein YtfJ
CBC4_RS06425	COG1686	Belongs to the peptidase S11 family
CBC4_RS06435	COG1940	carbohydrate kinase activity
CBC4_RS06460	COG0561	phosphatase activity
CBC4_RS06545	COG3328	transposase activity
CBC4_RS06550	COG3119	arylsulfatase activity
CBC4_RS06555	COG4974	Belongs to the 'phage' integrase family
CBC4_RS06565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CBC4_RS06570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CBC4_RS06575	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CBC4_RS06580	COG1923	regulation of RNA biosynthetic process
CBC4_RS06585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CBC4_RS06590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBC4_RS06595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CBC4_RS06600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBC4_RS06610	COG0494	nUDIX hydrolase
CBC4_RS06615	COG1061	Type III restriction enzyme res subunit
CBC4_RS06650	COG2205	protein histidine kinase activity
CBC4_RS06665	COG1136	(ABC) transporter
CBC4_RS06675	COG4185	zeta toxin
CBC4_RS06710	COG0577	efflux transmembrane transporter activity
CBC4_RS06715	COG1136	(ABC) transporter
CBC4_RS06720	COG1131	(ABC) transporter
CBC4_RS06730	COG0318	PFAM AMP-dependent synthetase and ligase
CBC4_RS06740	COG1268	BioY protein
CBC4_RS06750	COG0531	amino acid
CBC4_RS06755	COG0596	Alpha beta hydrolase
CBC4_RS06760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CBC4_RS06775	COG3328	transposase activity
CBC4_RS06800	COG1132	(ABC) transporter
CBC4_RS06805	COG1132	(ABC) transporter
CBC4_RS06805	COG2375	cellular response to nickel ion
CBC4_RS06810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBC4_RS06810	COG2207	Transcriptional regulator
CBC4_RS06825	COG0786	glutamate:sodium symporter activity
CBC4_RS06855	COG0539	negative regulation of cytoplasmic translation
CBC4_RS06855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CBC4_RS06860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CBC4_RS06865	COG2081	HI0933 family
CBC4_RS06870	COG1737	Transcriptional regulator
CBC4_RS06875	COG1187	pseudouridine synthase activity
CBC4_RS06880	COG0116	Belongs to the methyltransferase superfamily
CBC4_RS06900	COG0840	transmembrane signaling receptor activity
CBC4_RS06905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBC4_RS06910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBC4_RS06915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBC4_RS06925	COG1492	cobalamin metabolic process
CBC4_RS06935	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CBC4_RS06940	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CBC4_RS06945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CBC4_RS06950	COG0406	alpha-ribazole phosphatase activity
CBC4_RS07010	COG0488	(ABC) transporter
CBC4_RS07020	COG0628	permease
CBC4_RS07030	COG1846	Transcriptional regulator
CBC4_RS07035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CBC4_RS07050	COG3290	protein histidine kinase activity
CBC4_RS07055	COG4512	PFAM Accessory gene regulator B
CBC4_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
CBC4_RS07115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBC4_RS07125	COG1418	mRNA catabolic process
CBC4_RS07130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CBC4_RS07135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBC4_RS07140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBC4_RS07145	COG1674	ftsk spoiiie
CBC4_RS07150	COG0740	serine-type endopeptidase activity
CBC4_RS07155	COG0527	aspartate kinase activity
CBC4_RS07165	COG1185	polyribonucleotide nucleotidyltransferase activity
CBC4_RS07170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CBC4_RS07175	COG0196	riboflavin kinase activity
CBC4_RS07180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CBC4_RS07190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CBC4_RS07195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CBC4_RS07200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CBC4_RS07205	COG0195	Participates in both transcription termination and antitermination
CBC4_RS07210	COG0779	Required for maturation of 30S ribosomal subunits
CBC4_RS07220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CBC4_RS07225	COG0750	zinc metalloprotease
CBC4_RS07230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CBC4_RS07235	COG4589	Belongs to the CDS family
CBC4_RS07245	COG0233	cytoplasmic translational termination
CBC4_RS07250	COG0528	UMP kinase activity
CBC4_RS07255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CBC4_RS07260	COG0052	Belongs to the universal ribosomal protein uS2 family
CBC4_RS07265	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CBC4_RS07270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CBC4_RS07275	COG0758	DNA mediated transformation
CBC4_RS07280	COG0606	chelatase, subunit chli
CBC4_RS07285	COG0792	nuclease activity
CBC4_RS07290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBC4_RS07300	COG0335	large ribosomal subunit rRNA binding
CBC4_RS07305	COG0336	Belongs to the RNA methyltransferase TrmD family
CBC4_RS07310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CBC4_RS07315	COG1837	Belongs to the UPF0109 family
CBC4_RS07320	COG0228	four-way junction DNA binding
CBC4_RS07325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CBC4_RS07330	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CBC4_RS07335	COG0552	protein localization to endoplasmic reticulum
CBC4_RS07345	COG0366	Alpha amylase catalytic
CBC4_RS07345	COG3103	Sh3 type 3 domain protein
CBC4_RS07350	COG2359	stage V sporulation protein S
CBC4_RS07360	COG0571	ribonuclease III activity
CBC4_RS07365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBC4_RS07370	COG0416	fatty acid biosynthetic process
CBC4_RS07375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CBC4_RS07385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CBC4_RS07390	COG0280	phosphate acetyltransferase
CBC4_RS07395	COG1323	Belongs to the UPF0348 family
CBC4_RS07410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CBC4_RS07415	COG0742	ribosomal rna small subunit methyltransferase
CBC4_RS07420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CBC4_RS07425	COG1461	Dihydroxyacetone kinase
CBC4_RS07430	COG1302	Protein conserved in bacteria
CBC4_RS07435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CBC4_RS07445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CBC4_RS07450	COG1162	GTPase activity
CBC4_RS07455	COG2815	serine threonine protein kinase
CBC4_RS07455	COG0515	serine threonine protein kinase
CBC4_RS07460	COG0631	protein serine/threonine phosphatase activity
CBC4_RS07465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CBC4_RS07470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBC4_RS07470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CBC4_RS07475	COG2738	Putative neutral zinc metallopeptidase
CBC4_RS07480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CBC4_RS07485	COG0242	peptide deformylase activity
CBC4_RS07490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CBC4_RS07495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CBC4_RS07500	COG1758	RNA polymerase activity
CBC4_RS07510	COG2052	Domain of unknown function (DUF370)
CBC4_RS07515	COG1561	YicC-like family, N-terminal region
CBC4_RS07520	COG2252	PERMEase
CBC4_RS07530	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBC4_RS07535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CBC4_RS07540	COG1160	GTP binding
CBC4_RS07550	COG0704	Plays a role in the regulation of phosphate uptake
CBC4_RS07555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CBC4_RS07560	COG0581	inorganic phosphate transmembrane transporter activity
CBC4_RS07565	COG0573	inorganic phosphate transmembrane transporter activity
CBC4_RS07575	COG5002	protein histidine kinase activity
CBC4_RS07580	COG0745	RESPONSE REGULATOR receiver
CBC4_RS07585	COG1496	oxidoreductase activity
CBC4_RS07590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CBC4_RS07595	COG1873	PFAM PRC-barrel domain
CBC4_RS07610	COG1191	sigma factor activity
CBC4_RS07615	COG1191	sigma factor activity
CBC4_RS07625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CBC4_RS07650	COG0572	uridine kinase
CBC4_RS07655	COG0826	peptidase U32
CBC4_RS07660	COG4122	O-methyltransferase activity
CBC4_RS07665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CBC4_RS07670	COG1217	gtp-binding protein TYPA
CBC4_RS07675	COG3679	Belongs to the UPF0342 family
CBC4_RS07680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CBC4_RS07685	COG0735	belongs to the Fur family
CBC4_RS07695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CBC4_RS07700	COG4472	Bacterial protein of unknown function (DUF965)
CBC4_RS07705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBC4_RS07710	COG0482	sulfurtransferase activity
CBC4_RS07715	COG0822	iron-sulfur transferase activity
CBC4_RS07725	COG1959	2 iron, 2 sulfur cluster binding
CBC4_RS07745	COG0488	(ABC) transporter
CBC4_RS07775	COG3655	Transcriptional regulator
CBC4_RS07810	COG3764	Sortase (surface protein transpeptidase)
CBC4_RS07840	COG0697	spore germination
CBC4_RS07850	COG0514	ATP-dependent DNA helicase (RecQ)
CBC4_RS07855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBC4_RS07870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBC4_RS07880	COG1321	iron dependent repressor
CBC4_RS07890	COG3344	reverse transcriptase
CBC4_RS07895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CBC4_RS07905	COG0534	Mate efflux family protein
CBC4_RS07915	COG5002	protein histidine kinase activity
CBC4_RS07920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBC4_RS07920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBC4_RS07935	COG2608	mercury ion transmembrane transporter activity
CBC4_RS07940	COG2217	Heavy metal translocating P-type atpase
CBC4_RS07945	COG1937	Protein conserved in bacteria
CBC4_RS07950	COG0612	Peptidase, M16
CBC4_RS07960	COG1024	Enoyl-CoA hydratase
CBC4_RS07965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBC4_RS07970	COG2086	electron transfer activity
CBC4_RS07975	COG1960	acyl-CoA dehydrogenase activity
CBC4_RS07980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CBC4_RS07985	COG0187	DNA topoisomerase II activity
CBC4_RS08005	COG0813	purine-nucleoside phosphorylase activity
CBC4_RS08010	COG5278	phosphoserine phosphatase activity
CBC4_RS08010	COG0840	transmembrane signaling receptor activity
CBC4_RS08020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CBC4_RS08025	COG0840	transmembrane signaling receptor activity
CBC4_RS08060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CBC4_RS08065	COG3842	ATPase activity
CBC4_RS08085	COG0835	chemotaxis
CBC4_RS08085	COG0784	Response regulator, receiver
CBC4_RS08095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBC4_RS08100	COG0840	transmembrane signaling receptor activity
CBC4_RS08110	COG0840	transmembrane signaling receptor activity
CBC4_RS08115	COG1073	alpha beta
CBC4_RS08125	COG0583	DNA-binding transcription factor activity
CBC4_RS08145	COG1051	belongs to the nudix hydrolase family
CBC4_RS08150	COG0840	transmembrane signaling receptor activity
CBC4_RS08155	COG0534	Mate efflux family protein
CBC4_RS08160	COG3300	MHYT domain
CBC4_RS08160	COG5001	Diguanylate cyclase
CBC4_RS08170	COG1028	Short-chain dehydrogenase reductase Sdr
CBC4_RS08190	COG0733	neurotransmitter:sodium symporter activity
CBC4_RS08205	COG0840	transmembrane signaling receptor activity
CBC4_RS08215	COG1704	LemA family
CBC4_RS08220	COG4086	secreted protein
CBC4_RS08235	COG0833	amino acid
CBC4_RS08250	COG0840	transmembrane signaling receptor activity
CBC4_RS08280	COG1477	protein flavinylation
CBC4_RS08300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CBC4_RS08405	COG3716	PTS system mannose fructose sorbose family IID component
CBC4_RS08410	COG3715	PTS system
CBC4_RS08415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CBC4_RS08420	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CBC4_RS08435	COG2207	Transcriptional regulator
CBC4_RS08475	COG0662	Cupin 2, conserved barrel domain protein
CBC4_RS08500	COG1668	transmembrane transport
CBC4_RS08505	COG4152	abc transporter atp-binding protein
CBC4_RS08550	COG2814	Major facilitator Superfamily
CBC4_RS08565	COG4869	propanediol catabolic process
CBC4_RS08570	COG1454	alcohol dehydrogenase
CBC4_RS08570	COG1012	belongs to the aldehyde dehydrogenase family
CBC4_RS08580	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CBC4_RS08605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CBC4_RS08610	COG1882	Formate acetyltransferase
CBC4_RS08615	COG1454	alcohol dehydrogenase
CBC4_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
CBC4_RS08620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CBC4_RS08640	COG0789	Transcriptional regulator
CBC4_RS08655	COG1331	Highly conserved protein containing a thioredoxin domain
CBC4_RS08665	COG0534	Mate efflux family protein
CBC4_RS08670	COG1309	transcriptional regulator
CBC4_RS08705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBC4_RS08715	COG2252	PERMEase
CBC4_RS08725	COG0138	bifunctional purine biosynthesis protein purh
CBC4_RS08730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CBC4_RS08735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CBC4_RS08740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CBC4_RS08745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CBC4_RS08750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CBC4_RS08755	COG1115	amino acid carrier protein
CBC4_RS08760	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CBC4_RS08765	COG4684	Psort location CytoplasmicMembrane, score
CBC4_RS08770	COG1114	Component of the transport system for branched-chain amino acids
CBC4_RS08775	COG1918	ferrous iron import across plasma membrane
CBC4_RS08775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBC4_RS08805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBC4_RS08855	COG0697	spore germination
CBC4_RS08860	COG1396	sequence-specific DNA binding
CBC4_RS08870	COG0456	acetyltransferase
CBC4_RS08870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CBC4_RS08875	COG1619	proteins homologs of microcin C7 resistance protein MccF
CBC4_RS08880	COG2205	protein histidine kinase activity
CBC4_RS08890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CBC4_RS08940	COG0840	transmembrane signaling receptor activity
CBC4_RS08955	COG3328	transposase activity
CBC4_RS08975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CBC4_RS08990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CBC4_RS08995	COG0358	DNA primase activity
CBC4_RS09005	COG0517	IMP dehydrogenase activity
CBC4_RS09015	COG1381	Involved in DNA repair and RecF pathway recombination
CBC4_RS09020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CBC4_RS09025	COG0295	cytidine deaminase activity
CBC4_RS09030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CBC4_RS09035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CBC4_RS09040	COG1480	7TM receptor with intracellular HD hydrolase
CBC4_RS09055	COG1610	YqeY-like protein
CBC4_RS09060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CBC4_RS09065	COG0537	adenosine 5'-monophosphoramidase activity
CBC4_RS09070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBC4_RS09075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CBC4_RS09080	COG2264	protein methyltransferase activity
CBC4_RS09085	COG0484	heat shock protein binding
CBC4_RS09090	COG0443	Heat shock 70 kDa protein
CBC4_RS09095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CBC4_RS09100	COG1420	regulation of RNA biosynthetic process
CBC4_RS09105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBC4_RS09110	COG0481	GTPase activity
CBC4_RS09130	COG0268	Binds directly to 16S ribosomal RNA
CBC4_RS09135	COG1466	dna polymerase III delta subunit
CBC4_RS09140	COG2333	competence protein COMEC
CBC4_RS09140	COG0658	competence protein
CBC4_RS09155	COG1555	photosystem II stabilization
CBC4_RS09155	COG1596	polysaccharide export
CBC4_RS09160	COG1686	Belongs to the peptidase S11 family
CBC4_RS09165	COG0564	pseudouridine synthase activity
CBC4_RS09175	COG1713	HD superfamily hydrolase involved in NAD metabolism
CBC4_RS09180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CBC4_RS09185	COG1534	Rna-binding protein
CBC4_RS09190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBC4_RS09200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CBC4_RS09210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CBC4_RS09215	COG1530	ribonuclease E activity
CBC4_RS09235	COG1994	Peptidase M50
CBC4_RS09240	COG0739	heme binding
CBC4_RS09250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CBC4_RS09260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CBC4_RS09265	COG0719	Fe-S assembly protein
CBC4_RS09270	COG1136	(ABC) transporter
CBC4_RS09280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CBC4_RS09285	COG0840	transmembrane signaling receptor activity
CBC4_RS09295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBC4_RS09315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBC4_RS09315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CBC4_RS09320	COG1728	Protein conserved in bacteria
CBC4_RS09335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CBC4_RS09345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CBC4_RS09355	COG1522	sequence-specific DNA binding
CBC4_RS09360	COG2155	Conserved Protein
CBC4_RS09370	COG1757	Na H antiporter
CBC4_RS09375	COG0165	Argininosuccinate lyase
CBC4_RS09380	COG0137	argininosuccinate synthase activity
CBC4_RS09385	COG1126	abc transporter atp-binding protein
CBC4_RS09390	COG0765	amino acid transport
CBC4_RS09395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBC4_RS09400	COG0473	3-isopropylmalate dehydrogenase activity
CBC4_RS09405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CBC4_RS09425	COG0658	competence protein
CBC4_RS09425	COG2333	competence protein COMEC
CBC4_RS09430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CBC4_RS09465	COG1968	undecaprenyl-diphosphatase activity
CBC4_RS09480	COG1609	Transcriptional regulator
CBC4_RS09490	COG1879	ABC-type sugar transport system periplasmic component
CBC4_RS09495	COG1172	Belongs to the binding-protein-dependent transport system permease family
CBC4_RS09500	COG1129	ABC transporter
CBC4_RS09505	COG1869	D-ribose catabolic process
CBC4_RS09525	COG0393	Putative heavy-metal-binding
CBC4_RS09545	COG3830	Belongs to the UPF0237 family
CBC4_RS09555	COG0840	transmembrane signaling receptor activity
CBC4_RS09560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CBC4_RS09565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBC4_RS09580	COG2996	Protein conserved in bacteria
CBC4_RS09590	COG3328	transposase activity
CBC4_RS09605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBC4_RS09610	COG1464	Belongs to the NlpA lipoprotein family
CBC4_RS09615	COG2011	ABC-type metal ion transport system permease component
CBC4_RS09620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CBC4_RS09625	COG0527	aspartate kinase activity
CBC4_RS09630	COG0024	Methionine aminopeptidase
CBC4_RS09645	COG0697	spore germination
CBC4_RS09650	COG2233	PERMEase
CBC4_RS09660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CBC4_RS09670	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CBC4_RS09675	COG0673	inositol 2-dehydrogenase activity
CBC4_RS09685	COG0673	inositol 2-dehydrogenase activity
CBC4_RS09695	COG3718	enzyme involved in inositol metabolism
CBC4_RS09700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBC4_RS09715	COG1349	DNA-binding transcription factor activity
CBC4_RS09730	COG0737	Belongs to the 5'-nucleotidase family
CBC4_RS09730	COG4085	toxin activity
CBC4_RS09730	COG1525	nuclease
CBC4_RS09745	COG0840	transmembrane signaling receptor activity
CBC4_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
CBC4_RS09765	COG0542	response to heat
CBC4_RS09785	COG5002	protein histidine kinase activity
CBC4_RS09790	COG4667	esterase of the alpha-beta hydrolase superfamily
CBC4_RS09810	COG0534	Mate efflux family protein
CBC4_RS09825	COG0697	spore germination
CBC4_RS09830	COG0372	Belongs to the citrate synthase family
CBC4_RS09835	COG0569	domain protein
CBC4_RS09835	COG0475	glutathione-regulated potassium exporter activity
CBC4_RS09840	COG0439	Biotin carboxylase
CBC4_RS09845	COG0511	ligase activity, forming carbon-carbon bonds
CBC4_RS09850	COG1914	H( )-stimulated, divalent metal cation uptake system
CBC4_RS09855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CBC4_RS09860	COG1984	allophanate hydrolase subunit 2
CBC4_RS09865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CBC4_RS09870	COG0039	L-malate dehydrogenase activity
CBC4_RS09880	COG0105	UTP biosynthetic process
CBC4_RS09890	COG0646	methionine synthase
CBC4_RS09890	COG1410	methionine synthase
CBC4_RS09895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CBC4_RS09900	COG1131	(ABC) transporter
CBC4_RS09915	COG1131	(ABC) transporter
CBC4_RS09920	COG1725	Transcriptional regulator
CBC4_RS09925	COG1752	Esterase of the alpha-beta hydrolase superfamily
CBC4_RS09930	COG0351	phosphomethylpyrimidine kinase
CBC4_RS09935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CBC4_RS09940	COG0352	thiamine-phosphate diphosphorylase activity
CBC4_RS09980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBC4_RS09985	COG0113	porphobilinogen synthase activity
CBC4_RS09995	COG0181	hydroxymethylbilane synthase activity
CBC4_RS10000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CBC4_RS10000	COG1648	precorrin-2 dehydrogenase activity
CBC4_RS10005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CBC4_RS10015	COG2056	Na+-H+ antiporter family
CBC4_RS10055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CBC4_RS10065	COG2070	2-Nitropropane dioxygenase
CBC4_RS10080	COG0488	(ABC) transporter
CBC4_RS10085	COG0745	RESPONSE REGULATOR receiver
CBC4_RS10090	COG5002	protein histidine kinase activity
CBC4_RS10090	COG3850	Histidine kinase
CBC4_RS10095	COG1136	(ABC) transporter
CBC4_RS10125	COG0436	Aminotransferase
CBC4_RS10130	COG0534	Mate efflux family protein
CBC4_RS10145	COG3344	reverse transcriptase
CBC4_RS10170	COG1105	Belongs to the carbohydrate kinase PfkB family
CBC4_RS10185	COG2222	sugar isomerase
CBC4_RS10190	COG2188	Transcriptional regulator
CBC4_RS10200	COG0641	radical SAM
CBC4_RS10215	COG3119	arylsulfatase activity
CBC4_RS10220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CBC4_RS10230	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CBC4_RS10235	COG2188	Transcriptional regulator
CBC4_RS10250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CBC4_RS10265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBC4_RS10310	COG0419	ATPase involved in DNA repair
CBC4_RS10345	COG0210	DNA helicase
CBC4_RS10355	COG2610	gluconate transmembrane transporter activity
CBC4_RS10360	COG2610	gluconate transmembrane transporter activity
CBC4_RS10375	COG3711	transcriptional antiterminator
CBC4_RS10380	COG1263	PTS System
CBC4_RS10380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CBC4_RS10380	COG2190	(PTS) system
CBC4_RS10385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBC4_RS10390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBC4_RS10400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CBC4_RS10405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBC4_RS10410	COG4708	membrane
CBC4_RS10415	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CBC4_RS10465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CBC4_RS10465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CBC4_RS10470	COG0741	lytic transglycosylase activity
CBC4_RS10495	COG2333	competence protein COMEC
CBC4_RS10495	COG0658	competence protein
CBC4_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
CBC4_RS10515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CBC4_RS10520	COG1994	Peptidase M50
CBC4_RS10530	COG4632	Exopolysaccharide biosynthesis protein
CBC4_RS10530	COG5434	Belongs to the glycosyl hydrolase 28 family
CBC4_RS10540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CBC4_RS10545	COG0735	belongs to the Fur family
CBC4_RS10570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CBC4_RS10575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CBC4_RS10580	COG1067	ATP-dependent peptidase activity
CBC4_RS10580	COG0470	DNA polymerase III
CBC4_RS10585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CBC4_RS10590	COG0740	serine-type endopeptidase activity
CBC4_RS10595	COG0544	peptidyl-prolyl cis-trans isomerase activity
CBC4_RS10610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBC4_RS10615	COG0505	Belongs to the CarA family
CBC4_RS10620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CBC4_RS10625	COG1882	Formate acetyltransferase
CBC4_RS10645	COG0167	dihydroorotate dehydrogenase activity
CBC4_RS10650	COG0543	2 iron, 2 sulfur cluster binding
CBC4_RS10655	COG0284	orotidine-5'-phosphate decarboxylase activity
CBC4_RS10665	COG0540	Belongs to the ATCase OTCase family
CBC4_RS10680	COG1131	(ABC) transporter
CBC4_RS10710	COG3290	protein histidine kinase activity
CBC4_RS10720	COG4670	ketone body catabolic process
CBC4_RS10725	COG3290	protein histidine kinase activity
CBC4_RS10725	COG3829	transcription factor binding
CBC4_RS10730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBC4_RS10735	COG1301	dicarboxylic acid transport
CBC4_RS10850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CBC4_RS10870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CBC4_RS10885	COG1447	Phosphotransferase system cellobiose-specific component IIA
CBC4_RS10900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CBC4_RS10910	COG4166	transmembrane transport
CBC4_RS10920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CBC4_RS10925	COG0154	amidase activity
CBC4_RS10955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CBC4_RS10965	COG4496	protein, YerC YecD
CBC4_RS10970	COG1187	pseudouridine synthase activity
CBC4_RS10980	COG1523	belongs to the glycosyl hydrolase 13 family
CBC4_RS10985	COG1671	Belongs to the UPF0178 family
CBC4_RS10995	COG0166	Belongs to the GPI family
CBC4_RS11000	COG0726	polysaccharide deacetylase
CBC4_RS11035	COG3279	Response regulator of the LytR AlgR family
CBC4_RS11050	COG0519	Catalyzes the synthesis of GMP from XMP
CBC4_RS11055	COG0516	GMP reductase activity
CBC4_RS11055	COG0517	IMP dehydrogenase activity
CBC4_RS11060	COG0037	tRNA processing
CBC4_RS11065	COG0459	protein refolding
CBC4_RS11070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CBC4_RS11085	COG0493	'glutamate synthase
CBC4_RS11105	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBC4_RS11110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBC4_RS11115	COG2086	electron transfer activity
CBC4_RS11120	COG1960	acyl-CoA dehydrogenase activity
CBC4_RS11125	COG1024	Enoyl-CoA hydratase
CBC4_RS11130	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CBC4_RS11135	COG0488	(ABC) transporter
CBC4_RS11140	COG3328	transposase activity
CBC4_RS11145	COG0747	negative chemotaxis
CBC4_RS11150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CBC4_RS11160	COG0492	ferredoxin-NADP+ reductase activity
CBC4_RS11185	COG2059	Chromate
CBC4_RS11195	COG0840	transmembrane signaling receptor activity
CBC4_RS11210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CBC4_RS11215	COG0802	atpase or kinase
CBC4_RS11220	COG1214	PFAM Peptidase M22, glycoprotease
CBC4_RS11225	COG0456	acetyltransferase
CBC4_RS11230	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CBC4_RS11235	COG2183	response to ionizing radiation
CBC4_RS11245	COG2234	aminopeptidase activity
CBC4_RS11260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CBC4_RS11265	COG0653	protein targeting
CBC4_RS11275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CBC4_RS11280	COG1040	competence protein
CBC4_RS11290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CBC4_RS11295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CBC4_RS11320	COG0037	tRNA processing
CBC4_RS11335	COG1609	Transcriptional regulator
CBC4_RS11345	COG2385	sporulation resulting in formation of a cellular spore
CBC4_RS11360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CBC4_RS11365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CBC4_RS11370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CBC4_RS11375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CBC4_RS11380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBC4_RS11385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CBC4_RS11390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBC4_RS11395	COG0356	it plays a direct role in the translocation of protons across the membrane
CBC4_RS11405	COG0183	Belongs to the thiolase family
CBC4_RS11410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBC4_RS11415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBC4_RS11425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CBC4_RS11430	COG0698	ribose 5-phosphate isomerase
CBC4_RS11435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CBC4_RS11440	COG0009	L-threonylcarbamoyladenylate synthase
CBC4_RS11445	COG0428	transporter
CBC4_RS11455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CBC4_RS11465	COG3872	metal-dependent enzyme
CBC4_RS11470	COG1435	thymidine kinase activity
CBC4_RS11475	COG0254	rRNA binding
CBC4_RS11480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CBC4_RS11490	COG0504	CTP synthase activity
CBC4_RS11500	COG0482	sulfurtransferase activity
CBC4_RS11505	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBC4_RS11510	COG2959	enzyme of heme biosynthesis
CBC4_RS11525	COG0814	amino acid
CBC4_RS11530	COG0697	spore germination
CBC4_RS11540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CBC4_RS11545	COG0791	NLP P60 protein
CBC4_RS11545	COG1388	LysM domain
CBC4_RS11550	COG4466	Protein conserved in bacteria
CBC4_RS11585	COG2099	Precorrin-6x reductase
CBC4_RS11615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CBC4_RS11615	COG1648	precorrin-2 dehydrogenase activity
CBC4_RS11620	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CBC4_RS11660	COG0840	transmembrane signaling receptor activity
CBC4_RS11675	COG1151	hydroxylamine reductase activity
CBC4_RS11680	COG0840	transmembrane signaling receptor activity
CBC4_RS11690	COG3942	CHAP domain
CBC4_RS11690	COG1388	LysM domain
CBC4_RS11720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBC4_RS11725	COG0662	Cupin 2, conserved barrel domain protein
CBC4_RS11725	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CBC4_RS11730	COG0183	Belongs to the thiolase family
CBC4_RS11735	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBC4_RS11745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CBC4_RS11750	COG0840	transmembrane signaling receptor activity
CBC4_RS11760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CBC4_RS11770	COG0446	pyridine nucleotide-disulphide oxidoreductase
CBC4_RS11780	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CBC4_RS11790	COG0006	proline dipeptidase activity
CBC4_RS11795	COG2045	Belongs to the ComB family
CBC4_RS11820	COG0077	Prephenate dehydratase
CBC4_RS11820	COG1605	Chorismate mutase
CBC4_RS11825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CBC4_RS11830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CBC4_RS11835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CBC4_RS11840	COG0287	Prephenate dehydrogenase
CBC4_RS11845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CBC4_RS11855	COG1174	glycine betaine transport
CBC4_RS11860	COG1125	glycine betaine transport
CBC4_RS11860	COG0517	IMP dehydrogenase activity
CBC4_RS11870	COG1924	4 iron, 4 sulfur cluster binding
CBC4_RS11885	COG3344	reverse transcriptase
CBC4_RS11910	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CBC4_RS11920	COG2323	membrane
CBC4_RS11930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CBC4_RS11945	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBC4_RS11950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBC4_RS11970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CBC4_RS11985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CBC4_RS11985	COG0517	IMP dehydrogenase activity
CBC4_RS11995	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CBC4_RS12000	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBC4_RS12015	COG2310	stress, protein
CBC4_RS12020	COG2310	stress, protein
CBC4_RS12025	COG2310	stress, protein
CBC4_RS12035	COG1151	hydroxylamine reductase activity
CBC4_RS12040	COG2252	PERMEase
CBC4_RS12060	COG3853	Toxic anion resistance protein (TelA)
CBC4_RS12070	COG1285	pathogenesis
CBC4_RS12095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CBC4_RS12105	COG3584	3D domain protein
CBC4_RS12105	COG3583	domain protein
CBC4_RS12110	COG0084	hydrolase, TatD family'
CBC4_RS12120	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CBC4_RS12130	COG2376	Dihydroxyacetone kinase
CBC4_RS12135	COG4399	Belongs to the UPF0754 family
CBC4_RS12140	COG0726	polysaccharide deacetylase
CBC4_RS12155	COG0745	RESPONSE REGULATOR receiver
CBC4_RS12160	COG5002	protein histidine kinase activity
CBC4_RS12170	COG0726	polysaccharide deacetylase
CBC4_RS12175	COG1573	uracil-dna glycosylase
CBC4_RS12180	COG0534	Mate efflux family protein
CBC4_RS12185	COG0083	homoserine kinase activity
CBC4_RS12195	COG0700	Nucleoside recognition
CBC4_RS12200	COG2715	membrane protein required for spore maturation
CBC4_RS12205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CBC4_RS12210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBC4_RS12210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBC4_RS12230	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBC4_RS12240	COG5002	protein histidine kinase activity
CBC4_RS12260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CBC4_RS12265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CBC4_RS12275	COG4193	domain, Protein
CBC4_RS12285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CBC4_RS12295	COG0534	Mate efflux family protein
CBC4_RS12300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CBC4_RS12305	COG1733	regulation of RNA biosynthetic process
CBC4_RS12320	COG1115	amino acid carrier protein
CBC4_RS12350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CBC4_RS12355	COG0617	tRNA 3'-terminal CCA addition
CBC4_RS12360	COG2002	toxin-antitoxin pair type II binding
CBC4_RS12365	COG3103	Sh3 type 3 domain protein
CBC4_RS12365	COG1388	LysM domain
CBC4_RS12365	COG0791	NLP P60 protein
CBC4_RS12370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CBC4_RS12375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CBC4_RS12385	COG1346	cytolysis
CBC4_RS12400	COG1774	PSP1 C-terminal conserved region
CBC4_RS12410	COG3870	Protein conserved in bacteria
CBC4_RS12415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CBC4_RS12420	COG1982	Orn Lys Arg decarboxylase major
CBC4_RS12435	COG1376	ErfK ybiS ycfS ynhG family protein
CBC4_RS12455	COG1619	proteins homologs of microcin C7 resistance protein MccF
CBC4_RS12460	COG0733	neurotransmitter:sodium symporter activity
CBC4_RS12465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CBC4_RS12490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CBC4_RS12540	COG1131	(ABC) transporter
CBC4_RS12545	COG1725	Transcriptional regulator
CBC4_RS12555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CBC4_RS12580	COG1363	Peptidase, m42
CBC4_RS12585	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBC4_RS12590	COG0668	transmembrane transport
CBC4_RS12615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBC4_RS12625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CBC4_RS12645	COG2816	NAD+ diphosphatase activity
CBC4_RS12650	COG1489	DNA binding
CBC4_RS12720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CBC4_RS12725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CBC4_RS12730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CBC4_RS12750	COG0590	tRNA wobble adenosine to inosine editing
CBC4_RS12765	COG0688	phosphatidylethanolamine metabolic process
CBC4_RS12770	COG1234	tRNA 3'-trailer cleavage
CBC4_RS12800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CBC4_RS12820	COG1615	UPF0182 protein
CBC4_RS12825	COG1827	regulation of RNA biosynthetic process
CBC4_RS12860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CBC4_RS12865	COG0187	DNA topoisomerase II activity
CBC4_RS12875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBC4_RS12880	COG2501	S4 domain
CBC4_RS12885	COG0592	DNA-directed DNA polymerase activity
CBC4_RS12890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CBC4_RS12905	COG1847	R3H domain protein
CBC4_RS12910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CBC4_RS12930	COG1192	Involved in chromosome partitioning
CBC4_RS12965	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CBC4_RS13000	COG0460	homoserine dehydrogenase
CBC4_RS13125	COG0439	Biotin carboxylase
CBC4_RS13140	COG0825	malonyl-CoA metabolic process
CBC4_RS13365	COG1136	(ABC) transporter
CBC4_RS14025	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CBC4_RS14110	COG2081	HI0933 family
CBC4_RS14430	COG0445	tRNA wobble uridine modification
CBC4_RS14485	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CBC4_RS14705	COG1546	Belongs to the CinA family
CBC4_RS14705	COG1058	Belongs to the CinA family
CBC4_RS14855	COG0445	tRNA wobble uridine modification
CBC4_RS14860	COG0445	tRNA wobble uridine modification
CBC4_RS15025	COG2081	HI0933 family
CBC4_RS15130	COG3209	COG3209 Rhs family protein
CBC4_RS15140	COG1388	LysM domain
CBC4_RS15140	COG1705	Flagellar rod assembly protein muramidase FlgJ
CBC4_RS15150	COG0577	efflux transmembrane transporter activity
CBC4_RS15150	COG1136	(ABC) transporter
CBC4_RS15165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner