locus-tag	class	description
T259_RS00005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T259_RS00035	COG0398	Pfam SNARE associated Golgi protein
T259_RS00040	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
T259_RS00050	COG3850	Histidine kinase
T259_RS00050	COG5002	protein histidine kinase activity
T259_RS00055	COG0745	RESPONSE REGULATOR receiver
T259_RS00065	COG0671	phosphoesterase, PA-phosphatase related
T259_RS00095	COG0006	proline dipeptidase activity
T259_RS00100	COG0531	amino acid
T259_RS00105	COG1396	sequence-specific DNA binding
T259_RS00105	COG3800	Transcriptional regulator
T259_RS00110	COG0037	tRNA processing
T259_RS00135	COG5002	protein histidine kinase activity
T259_RS00150	COG3706	GGDEF domain
T259_RS00195	COG2801	Transposase and inactivated derivatives
T259_RS00200	COG1346	cytolysis
T259_RS00210	COG0577	efflux transmembrane transporter activity
T259_RS00215	COG1136	(ABC) transporter
T259_RS00220	COG1968	undecaprenyl-diphosphatase activity
T259_RS00225	COG2205	protein histidine kinase activity
T259_RS00230	COG0745	RESPONSE REGULATOR receiver
T259_RS00250	COG1132	(ABC) transporter
T259_RS00255	COG1120	ATPase activity
T259_RS00260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS00265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS00270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T259_RS00275	COG2207	Transcriptional regulator
T259_RS00275	COG1609	Transcriptional regulator
T259_RS00280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T259_RS00295	COG1120	ATPase activity
T259_RS00300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS00315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
T259_RS00320	COG2246	polysaccharide biosynthetic process
T259_RS00325	COG0463	Glycosyl transferase, family 2
T259_RS00330	COG2205	protein histidine kinase activity
T259_RS00330	COG2770	Histidine kinase
T259_RS00335	COG0745	RESPONSE REGULATOR receiver
T259_RS00345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T259_RS00355	COG0129	dihydroxy-acid dehydratase activity
T259_RS00360	COG2190	(PTS) system
T259_RS00360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS00360	COG1263	PTS System
T259_RS00370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS00370	COG1263	PTS System
T259_RS00375	COG1737	Transcriptional regulator
T259_RS00380	COG2910	NAD(P)H-binding
T259_RS00390	COG1959	2 iron, 2 sulfur cluster binding
T259_RS00400	COG1278	Cold shock
T259_RS00415	COG1263	PTS System
T259_RS00415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS00415	COG2190	(PTS) system
T259_RS00420	COG1486	melibiose metabolic process
T259_RS00425	COG1263	PTS System
T259_RS00425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS00430	COG0577	efflux transmembrane transporter activity
T259_RS00435	COG1136	(ABC) transporter
T259_RS00440	COG5002	protein histidine kinase activity
T259_RS00445	COG0745	RESPONSE REGULATOR receiver
T259_RS00450	COG2190	(PTS) system
T259_RS00465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS00465	COG1263	PTS System
T259_RS00470	COG1486	melibiose metabolic process
T259_RS00485	COG2205	protein histidine kinase activity
T259_RS00495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
T259_RS00500	COG0785	Cytochrome C biogenesis protein
T259_RS00520	COG2323	membrane
T259_RS00530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T259_RS00560	COG2176	DNA-directed DNA polymerase activity
T259_RS00590	COG0833	amino acid
T259_RS00600	COG0596	Alpha beta hydrolase
T259_RS00610	COG1136	(ABC) transporter
T259_RS00615	COG2205	protein histidine kinase activity
T259_RS00620	COG0745	RESPONSE REGULATOR receiver
T259_RS00625	COG0662	Cupin 2, conserved barrel domain protein
T259_RS00640	COG0076	glutamate decarboxylase activity
T259_RS00660	COG2226	methyltransferase
T259_RS00680	COG0557	exoribonuclease II activity
T259_RS00710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
T259_RS00720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
T259_RS00730	COG1079	Belongs to the binding-protein-dependent transport system permease family
T259_RS00735	COG4603	Belongs to the binding-protein-dependent transport system permease family
T259_RS00740	COG3845	ABC transporter
T259_RS00745	COG1744	ABC transporter substrate-binding protein PnrA-like
T259_RS00750	COG1307	EDD domain protein, DegV family
T259_RS00755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
T259_RS00760	COG1533	DNA photolyase activity
T259_RS00765	COG2720	vancomycin resistance protein
T259_RS00770	COG2720	vancomycin resistance protein
T259_RS00775	COG1363	Peptidase, m42
T259_RS00780	COG1073	alpha beta
T259_RS00790	COG0281	malic enzyme
T259_RS00795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
T259_RS00805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
T259_RS00810	COG1045	serine acetyltransferase
T259_RS00815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T259_RS00840	COG1597	lipid kinase activity
T259_RS00845	COG0517	IMP dehydrogenase activity
T259_RS00850	COG1183	phosphatidylcholine synthase activity
T259_RS00860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
T259_RS00865	COG2323	membrane
T259_RS00875	COG0191	fructose-bisphosphate aldolase activity
T259_RS00895	COG0484	heat shock protein binding
T259_RS00910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
T259_RS00925	COG2357	RelA SpoT domain protein
T259_RS00935	COG0446	pyridine nucleotide-disulphide oxidoreductase
T259_RS00960	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
T259_RS00965	COG2183	response to ionizing radiation
T259_RS01005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
T259_RS01040	COG0037	tRNA processing
T259_RS01055	COG1609	Transcriptional regulator
T259_RS01065	COG2385	sporulation resulting in formation of a cellular spore
T259_RS01115	COG0356	it plays a direct role in the translocation of protons across the membrane
T259_RS01125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
T259_RS01130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T259_RS01150	COG0698	ribose 5-phosphate isomerase
T259_RS01155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
T259_RS01160	COG0009	L-threonylcarbamoyladenylate synthase
T259_RS01185	COG3872	metal-dependent enzyme
T259_RS01190	COG1435	thymidine kinase activity
T259_RS01200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
T259_RS01210	COG0504	CTP synthase activity
T259_RS01230	COG2959	enzyme of heme biosynthesis
T259_RS01235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
T259_RS01250	COG0531	amino acid
T259_RS01255	COG0697	spore germination
T259_RS01265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
T259_RS01270	COG0189	ligase activity
T259_RS01270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
T259_RS01275	COG4242	Belongs to the peptidase S51 family
T259_RS01290	COG4466	Protein conserved in bacteria
T259_RS01325	COG3642	lipopolysaccharide core region biosynthetic process
T259_RS01335	COG1653	transport
T259_RS01345	COG1691	(AIR) carboxylase
T259_RS01350	COG1606	tRNA processing
T259_RS01355	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
T259_RS01360	COG0662	Cupin 2, conserved barrel domain protein
T259_RS01360	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
T259_RS01375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
T259_RS01380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
T259_RS01405	COG1328	CTP reductase activity
T259_RS01410	COG1285	pathogenesis
T259_RS01415	COG3706	GGDEF domain
T259_RS01430	COG1141	Ferredoxin
T259_RS01440	COG0577	efflux transmembrane transporter activity
T259_RS01445	COG1136	(ABC) transporter
T259_RS01480	COG3584	3D domain protein
T259_RS01480	COG3583	domain protein
T259_RS01485	COG0084	hydrolase, TatD family'
T259_RS01490	COG4399	Belongs to the UPF0754 family
T259_RS01495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T259_RS01495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T259_RS01505	COG1573	uracil-dna glycosylase
T259_RS01510	COG0534	Mate efflux family protein
T259_RS01515	COG1136	(ABC) transporter
T259_RS01515	COG0577	efflux transmembrane transporter activity
T259_RS01535	COG0700	Nucleoside recognition
T259_RS01540	COG2715	membrane protein required for spore maturation
T259_RS01550	COG0726	polysaccharide deacetylase
T259_RS01575	COG2002	toxin-antitoxin pair type II binding
T259_RS01580	COG0791	NLP P60 protein
T259_RS01585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
T259_RS01590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
T259_RS01605	COG1774	PSP1 C-terminal conserved region
T259_RS01610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
T259_RS01615	COG3870	Protein conserved in bacteria
T259_RS01625	COG1982	Orn Lys Arg decarboxylase major
T259_RS01650	COG1619	proteins homologs of microcin C7 resistance protein MccF
T259_RS01680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
T259_RS01785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T259_RS01795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
T259_RS01820	COG1489	DNA binding
T259_RS01845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
T259_RS01860	COG0626	cystathionine gamma-synthase activity
T259_RS01940	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
T259_RS01945	COG1827	regulation of RNA biosynthetic process
T259_RS01980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
T259_RS01985	COG0187	DNA topoisomerase II activity
T259_RS02005	COG0592	DNA-directed DNA polymerase activity
T259_RS02035	COG1847	R3H domain protein
T259_RS02055	COG1475	DNA binding
T259_RS02060	COG1192	Involved in chromosome partitioning
T259_RS02065	COG1475	DNA binding
T259_RS02085	COG0628	permease
T259_RS02100	COG0668	transmembrane transport
T259_RS02110	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
T259_RS02140	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
T259_RS02150	COG1067	ATP-dependent peptidase activity
T259_RS02150	COG0470	DNA polymerase III
T259_RS02155	COG0305	Participates in initiation and elongation during chromosome replication
T259_RS02160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T259_RS02190	COG2081	HI0933 family
T259_RS02270	COG0739	heme binding
T259_RS02290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T259_RS02300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
T259_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
T259_RS02310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T259_RS02315	COG0511	ligase activity, forming carbon-carbon bonds
T259_RS02320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
T259_RS02325	COG0439	Biotin carboxylase
T259_RS02335	COG0825	malonyl-CoA metabolic process
T259_RS02345	COG0583	DNA-binding transcription factor activity
T259_RS02350	COG1404	Belongs to the peptidase S8 family
T259_RS02355	COG0583	DNA-binding transcription factor activity
T259_RS02370	COG0613	PHP domain protein
T259_RS02375	COG0438	transferase activity, transferring glycosyl groups
T259_RS02385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
T259_RS02395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
T259_RS02405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
T259_RS02410	COG1328	CTP reductase activity
T259_RS02420	COG0024	Methionine aminopeptidase
T259_RS02430	COG1309	transcriptional regulator
T259_RS02440	COG2814	Major facilitator Superfamily
T259_RS02455	COG0653	protein targeting
T259_RS02465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
T259_RS02490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
T259_RS02500	COG3800	Transcriptional regulator
T259_RS02500	COG1396	sequence-specific DNA binding
T259_RS02505	COG0840	transmembrane signaling receptor activity
T259_RS02515	COG3949	Membrane
T259_RS02525	COG1242	4 iron, 4 sulfur cluster binding
T259_RS02540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T259_RS02565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
T259_RS02585	COG0745	RESPONSE REGULATOR receiver
T259_RS02590	COG5002	protein histidine kinase activity
T259_RS02595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T259_RS02605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
T259_RS02615	COG2002	toxin-antitoxin pair type II binding
T259_RS02620	COG2244	polysaccharide biosynthetic process
T259_RS02625	COG3956	TIGRFAM MazG family protein
T259_RS02635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
T259_RS02655	COG1098	S1 RNA binding domain
T259_RS02695	COG2208	phosphoserine phosphatase activity
T259_RS02705	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
T259_RS02710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T259_RS02725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
T259_RS02745	COG0423	glycine-tRNA ligase activity
T259_RS02785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
T259_RS02800	COG3880	PFAM UvrB UvrC protein
T259_RS02805	COG3869	Catalyzes the specific phosphorylation of arginine residues in
T259_RS02810	COG0542	response to heat
T259_RS02815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
T259_RS02830	COG4956	integral membrane protein (PIN domain superfamily)
T259_RS02845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
T259_RS02865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T259_RS02940	COG1358	cellular component organization or biogenesis
T259_RS03095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
T259_RS03125	COG1122	ATPase activity
T259_RS03135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
T259_RS03140	COG0101	tRNA pseudouridine synthase activity
T259_RS03155	COG1283	sodium-dependent phosphate transmembrane transporter activity
T259_RS03160	COG0860	N-Acetylmuramoyl-L-alanine amidase
T259_RS03165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
T259_RS03165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
T259_RS03180	COG3290	protein histidine kinase activity
T259_RS03180	COG3829	transcription factor binding
T259_RS03185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
T259_RS03200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
T259_RS03205	COG3118	belongs to the thioredoxin family
T259_RS03210	COG0492	ferredoxin-NADP+ reductase activity
T259_RS03220	COG3773	Cell wall hydrolase
T259_RS03225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
T259_RS03235	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
T259_RS03240	COG3426	butyrate kinase activity
T259_RS03245	COG0280	phosphate acetyltransferase
T259_RS03265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
T259_RS03265	COG0674	pyruvate-flavodoxin oxidoreductase activity
T259_RS03290	COG1063	alcohol dehydrogenase
T259_RS03305	COG3732	PTS system glucitol sorbitol-specific
T259_RS03315	COG1028	Short-chain dehydrogenase reductase Sdr
T259_RS03320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T259_RS03325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
T259_RS03330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T259_RS03335	COG2032	superoxide dismutase activity
T259_RS03370	COG1295	ribonuclease BN
T259_RS03385	COG0736	holo-[acyl-carrier-protein] synthase activity
T259_RS03390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
T259_RS03390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
T259_RS03400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
T259_RS03415	COG3959	Transketolase, thiamine diphosphate binding domain
T259_RS03420	COG3958	Transketolase
T259_RS03435	COG2884	Cell division ATP-binding protein ftsE
T259_RS03440	COG2177	Part of the ABC transporter FtsEX involved in
T259_RS03445	COG3409	Peptidoglycan-binding domain 1 protein
T259_RS03445	COG0793	Belongs to the peptidase S41A family
T259_RS03450	COG0750	zinc metalloprotease
T259_RS03465	COG1716	ATPase activity
T259_RS03475	COG0768	penicillin binding
T259_RS03485	COG1988	membrane-bound metal-dependent
T259_RS03510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
T259_RS03530	COG0469	pyruvate kinase activity
T259_RS03550	COG0741	lytic transglycosylase activity
T259_RS03560	COG0745	RESPONSE REGULATOR receiver
T259_RS03565	COG2205	protein histidine kinase activity
T259_RS03570	COG0577	efflux transmembrane transporter activity
T259_RS03570	COG1136	(ABC) transporter
T259_RS03595	COG1959	2 iron, 2 sulfur cluster binding
T259_RS03610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T259_RS03615	COG2207	Transcriptional regulator
T259_RS03615	COG3708	Transcriptional regulator
T259_RS03625	COG0295	cytidine deaminase activity
T259_RS03645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T259_RS03670	COG5566	PFAM Mor transcription activator
T259_RS03695	COG1486	melibiose metabolic process
T259_RS03700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
T259_RS03705	COG3933	PFAM sigma-54 factor interaction domain-containing protein
T259_RS03705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
T259_RS03715	COG1447	Phosphotransferase system cellobiose-specific component IIA
T259_RS03720	COG2971	BadF BadG BcrA BcrD
T259_RS03740	COG1131	(ABC) transporter
T259_RS03760	COG0659	secondary active sulfate transmembrane transporter activity
T259_RS03765	COG1595	DNA-templated transcription, initiation
T259_RS03775	COG1131	(ABC) transporter
T259_RS03785	COG2827	Endonuclease containing a URI domain
T259_RS03795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T259_RS03800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T259_RS03805	COG3973	AAA domain
T259_RS03815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
T259_RS03820	COG1362	aminopeptidase activity
T259_RS03835	COG3459	Glycosyltransferase 36 associated
T259_RS03845	COG2033	superoxide reductase activity
T259_RS03860	COG0561	phosphatase activity
T259_RS03865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
T259_RS03900	COG0456	acetyltransferase
T259_RS03905	COG1214	PFAM Peptidase M22, glycoprotease
T259_RS03910	COG0802	atpase or kinase
T259_RS03915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
T259_RS03940	COG0446	pyridine nucleotide-disulphide oxidoreductase
T259_RS03955	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
T259_RS03965	COG1966	Carbon starvation protein
T259_RS03970	COG3275	phosphorelay sensor kinase activity
T259_RS03975	COG3279	Response regulator of the LytR AlgR family
T259_RS03980	COG0488	(ABC) transporter
T259_RS04010	COG0398	Pfam SNARE associated Golgi protein
T259_RS04030	COG0037	tRNA processing
T259_RS04035	COG0517	IMP dehydrogenase activity
T259_RS04035	COG0516	GMP reductase activity
T259_RS04045	COG1114	Component of the transport system for branched-chain amino acids
T259_RS04050	COG0318	PFAM AMP-dependent synthetase and ligase
T259_RS04075	COG1960	acyl-CoA dehydrogenase activity
T259_RS04080	COG2086	electron transfer activity
T259_RS04085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
T259_RS04100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
T259_RS04110	COG1309	transcriptional regulator
T259_RS04125	COG1671	Belongs to the UPF0178 family
T259_RS04140	COG0741	lytic transglycosylase activity
T259_RS04145	COG1187	pseudouridine synthase activity
T259_RS04150	COG4496	protein, YerC YecD
T259_RS04205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
T259_RS04210	COG0622	Phosphoesterase
T259_RS04285	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
T259_RS04295	COG1924	4 iron, 4 sulfur cluster binding
T259_RS04320	COG0543	2 iron, 2 sulfur cluster binding
T259_RS04325	COG0167	dihydroorotate dehydrogenase activity
T259_RS04340	COG1082	Xylose isomerase domain protein TIM barrel
T259_RS04360	COG0470	DNA polymerase III
T259_RS04360	COG1067	ATP-dependent peptidase activity
T259_RS04365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
T259_RS04370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
T259_RS04395	COG2378	regulation of single-species biofilm formation
T259_RS04410	COG0735	belongs to the Fur family
T259_RS04440	COG1592	Rubrerythrin
T259_RS04440	COG1773	rubredoxin
T259_RS04445	COG0840	transmembrane signaling receptor activity
T259_RS04450	COG0584	glycerophosphoryl diester phosphodiesterase
T259_RS04470	COG0038	chloride channel
T259_RS04485	COG2252	PERMEase
T259_RS04500	COG1024	Enoyl-CoA hydratase
T259_RS04505	COG1250	3-hydroxyacyl-CoA dehydrogenase
T259_RS04510	COG0183	Belongs to the thiolase family
T259_RS04515	COG1960	acyl-CoA dehydrogenase activity
T259_RS04520	COG2086	electron transfer activity
T259_RS04525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
T259_RS04535	COG1924	4 iron, 4 sulfur cluster binding
T259_RS04565	COG0714	Associated with various cellular activities
T259_RS04580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
T259_RS04585	COG1396	sequence-specific DNA binding
T259_RS04600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
T259_RS04605	COG3123	guanosine phosphorylase activity
T259_RS04630	COG0612	Peptidase, M16
T259_RS04650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
T259_RS04655	COG1116	anion transmembrane transporter activity
T259_RS04665	COG2801	Transposase and inactivated derivatives
T259_RS04675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
T259_RS04680	COG1136	(ABC) transporter
T259_RS04685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T259_RS04715	COG0726	polysaccharide deacetylase
T259_RS04730	COG2171	N-acyltransferase activity
T259_RS04735	COG0436	Aminotransferase
T259_RS04740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
T259_RS04750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
T259_RS04760	COG0601	transmembrane transport
T259_RS04765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T259_RS04770	COG0444	Belongs to the ABC transporter superfamily
T259_RS04775	COG4608	Belongs to the ABC transporter superfamily
T259_RS04785	COG2226	methyltransferase
T259_RS04820	COG1131	(ABC) transporter
T259_RS04845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
T259_RS04860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
T259_RS04865	COG0569	domain protein
T259_RS04870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T259_RS04895	COG0463	Glycosyl transferase, family 2
T259_RS04915	COG0826	peptidase U32
T259_RS04925	COG1683	Conserved Protein
T259_RS04935	COG0280	phosphate acetyltransferase
T259_RS04945	COG1982	Orn Lys Arg decarboxylase major
T259_RS04950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
T259_RS04955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T259_RS04965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
T259_RS04970	COG4193	domain, Protein
T259_RS04990	COG1086	Polysaccharide biosynthesis protein
T259_RS05030	COG0438	transferase activity, transferring glycosyl groups
T259_RS05050	COG0438	transferase activity, transferring glycosyl groups
T259_RS05060	COG0728	peptidoglycan biosynthetic process
T259_RS05075	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
T259_RS05100	COG2172	sigma factor antagonist activity
T259_RS05115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T259_RS05135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
T259_RS05140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
T259_RS05145	COG1773	rubredoxin
T259_RS05160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T259_RS05170	COG1739	Uncharacterized protein family UPF0029
T259_RS05195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
T259_RS05205	COG1862	Preprotein translocase
T259_RS05225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
T259_RS05230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
T259_RS05230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
T259_RS05245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
T259_RS05255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
T259_RS05260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
T259_RS05345	COG1484	DNA-dependent DNA replication
T259_RS05495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T259_RS05495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T259_RS05500	COG0237	dephospho-CoA kinase activity
T259_RS05555	COG1077	Cell shape determining protein MreB Mrl
T259_RS05570	COG0768	penicillin binding
T259_RS05575	COG0850	regulation of cytokinetic process
T259_RS05580	COG2894	cell division
T259_RS05590	COG0772	Belongs to the SEDS family
T259_RS05595	COG0739	heme binding
T259_RS05640	COG1534	Rna-binding protein
T259_RS05650	COG1713	HD superfamily hydrolase involved in NAD metabolism
T259_RS05655	COG1316	TRANSCRIPTIONal
T259_RS05660	COG0251	oxidation-reduction process
T259_RS05665	COG0564	pseudouridine synthase activity
T259_RS05670	COG1686	Belongs to the peptidase S11 family
T259_RS05680	COG0709	Synthesizes selenophosphate from selenide and ATP
T259_RS05750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
T259_RS05770	COG0484	heat shock protein binding
T259_RS05780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
T259_RS05785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T259_RS05790	COG0537	adenosine 5'-monophosphoramidase activity
T259_RS05800	COG1610	YqeY-like protein
T259_RS05815	COG1480	7TM receptor with intracellular HD hydrolase
T259_RS05840	COG1381	Involved in DNA repair and RecF pathway recombination
T259_RS05845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
T259_RS05850	COG0517	IMP dehydrogenase activity
T259_RS05855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
T259_RS05855	COG0574	Belongs to the PEP-utilizing enzyme family
T259_RS05870	COG0358	DNA primase activity
T259_RS05875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T259_RS05890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
T259_RS05930	COG2801	Transposase and inactivated derivatives
T259_RS05940	COG0584	glycerophosphoryl diester phosphodiesterase
T259_RS05960	COG3773	Cell wall hydrolase
T259_RS05965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T259_RS05980	COG1725	Transcriptional regulator
T259_RS06000	COG1550	Protein conserved in bacteria
T259_RS06005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
T259_RS06025	COG1253	flavin adenine dinucleotide binding
T259_RS06030	COG1956	GAF domain-containing protein
T259_RS06035	COG4187	Peptidase family M20/M25/M40
T259_RS06055	COG3973	AAA domain
T259_RS06060	COG1115	amino acid carrier protein
T259_RS06065	COG2252	PERMEase
T259_RS06090	COG1120	ATPase activity
T259_RS06095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS06110	COG3608	succinylglutamate desuccinylase aspartoacylase
T259_RS06110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
T259_RS06120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
T259_RS06125	COG3829	transcription factor binding
T259_RS06135	COG2233	PERMEase
T259_RS06145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
T259_RS06150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
T259_RS06150	COG0493	'glutamate synthase
T259_RS06155	COG0402	S-adenosylhomocysteine deaminase activity
T259_RS06160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T259_RS06170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
T259_RS06180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
T259_RS06190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
T259_RS06200	COG0151	Belongs to the GarS family
T259_RS06215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
T259_RS06220	COG2195	Cleaves the N-terminal amino acid of tripeptides
T259_RS06235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
T259_RS06235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
T259_RS06245	COG0730	response to heat
T259_RS06250	COG1368	sulfuric ester hydrolase activity
T259_RS06280	COG1309	transcriptional regulator
T259_RS06285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T259_RS06295	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
T259_RS06315	COG0488	(ABC) transporter
T259_RS06360	COG0475	glutathione-regulated potassium exporter activity
T259_RS06370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T259_RS06380	COG2080	2 iron, 2 sulfur cluster binding
T259_RS06385	COG2068	MobA-Related Protein
T259_RS06395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
T259_RS06405	COG3716	PTS system mannose fructose sorbose family IID component
T259_RS06410	COG3715	PTS system
T259_RS06435	COG1960	acyl-CoA dehydrogenase activity
T259_RS06440	COG0426	domain, Protein
T259_RS06440	COG1773	rubredoxin
T259_RS06445	COG0534	Mate efflux family protein
T259_RS06450	COG0735	belongs to the Fur family
T259_RS06460	COG3842	ATPase activity
T259_RS06465	COG0719	Fe-S assembly protein
T259_RS06470	COG0534	Mate efflux family protein
T259_RS06475	COG1263	PTS System
T259_RS06475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS06485	COG3711	transcriptional antiterminator
T259_RS06490	COG2188	Transcriptional regulator
T259_RS06495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
T259_RS06500	COG0363	glucosamine-6-phosphate deaminase activity
T259_RS06515	COG0735	belongs to the Fur family
T259_RS06525	COG0840	transmembrane signaling receptor activity
T259_RS06535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
T259_RS06565	COG0493	'glutamate synthase
T259_RS06575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
T259_RS06590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T259_RS06595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T259_RS06615	COG1388	LysM domain
T259_RS06615	COG3584	3D domain protein
T259_RS06620	COG2066	Belongs to the glutaminase family
T259_RS06625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
T259_RS06635	COG0840	transmembrane signaling receptor activity
T259_RS06635	COG3290	protein histidine kinase activity
T259_RS06650	COG0513	Belongs to the DEAD box helicase family
T259_RS06665	COG0697	spore germination
T259_RS06670	COG0814	amino acid
T259_RS06685	COG0840	transmembrane signaling receptor activity
T259_RS06695	COG0840	transmembrane signaling receptor activity
T259_RS06710	COG1725	Transcriptional regulator
T259_RS06715	COG1131	(ABC) transporter
T259_RS06725	COG0393	Putative heavy-metal-binding
T259_RS06730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T259_RS06745	COG2207	Transcriptional regulator
T259_RS06760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
T259_RS06795	COG0187	DNA topoisomerase II activity
T259_RS06800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
T259_RS06805	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
T259_RS06840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
T259_RS06840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
T259_RS06845	COG5002	protein histidine kinase activity
T259_RS06880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
T259_RS06885	COG3711	transcriptional antiterminator
T259_RS06890	COG2190	(PTS) system
T259_RS06890	COG1263	PTS System
T259_RS06890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS06910	COG2201	protein-glutamate methylesterase activity
T259_RS06915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
T259_RS06920	COG0643	Histidine kinase
T259_RS06920	COG2198	Histidine kinase
T259_RS06925	COG1776	CheC inhibitor of MCP methylation
T259_RS06930	COG2201	protein-glutamate methylesterase activity
T259_RS06935	COG0835	chemotaxis
T259_RS06940	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
T259_RS06945	COG1776	CheC inhibitor of MCP methylation
T259_RS06945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
T259_RS06960	COG1256	bacterial-type flagellum assembly
T259_RS06960	COG4786	Flagellar basal body rod
T259_RS06990	COG1516	flagellar protein fliS
T259_RS06995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
T259_RS07005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
T259_RS07010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
T259_RS07030	COG0463	Glycosyl transferase, family 2
T259_RS07030	COG0457	Tetratricopeptide repeat
T259_RS07035	COG1086	Polysaccharide biosynthesis protein
T259_RS07040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
T259_RS07045	COG1181	Belongs to the D-alanine--D-alanine ligase family
T259_RS07055	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
T259_RS07060	COG2089	acid synthase
T259_RS07110	COG1216	Glycosyl transferase, family 2
T259_RS07115	COG1215	transferase activity, transferring glycosyl groups
T259_RS07125	COG0463	Glycosyl transferase, family 2
T259_RS07145	COG3980	spore coat polysaccharide biosynthesis protein
T259_RS07155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
T259_RS07160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
T259_RS07165	COG0840	transmembrane signaling receptor activity
T259_RS07185	COG1316	TRANSCRIPTIONal
T259_RS07190	COG3944	biosynthesis protein
T259_RS07195	COG4464	protein tyrosine phosphatase activity
T259_RS07200	COG0489	protein tyrosine kinase activity
T259_RS07210	COG0562	UDP-galactopyranose mutase
T259_RS07230	COG1083	cytidylyl-transferase
T259_RS07235	COG2089	acid synthase
T259_RS07260	COG4129	membrane
T259_RS07265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
T259_RS07295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
T259_RS07300	COG1815	bacterial-type flagellum-dependent cell motility
T259_RS07305	COG1558	bacterial-type flagellum-dependent cell motility
T259_RS07310	COG1677	Flagellar hook-basal body complex protein FliE
T259_RS07315	COG1766	The M ring may be actively involved in energy transduction
T259_RS07320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
T259_RS07330	COG1157	protein secretion by the type III secretion system
T259_RS07345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
T259_RS07355	COG4786	Flagellar basal body rod
T259_RS07360	COG1582	Flagellar protein (FlbD)
T259_RS07385	COG1338	Plays a role in the flagellum-specific transport system
T259_RS07395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
T259_RS07400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
T259_RS07405	COG1419	protein localization to endoplasmic reticulum
T259_RS07410	COG0455	bacterial-type flagellum organization
T259_RS07420	COG1191	sigma factor activity
T259_RS07435	COG4786	Flagellar basal body rod
T259_RS07455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T259_RS07485	COG1269	ATP hydrolysis coupled proton transport
T259_RS07490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
T259_RS07540	COG0426	domain, Protein
T259_RS07555	COG1494	fructose-1,6-bisphosphatase
T259_RS07560	COG0463	Glycosyl transferase, family 2
T259_RS07580	COG0398	Pfam SNARE associated Golgi protein
T259_RS07585	COG0398	Pfam SNARE associated Golgi protein
T259_RS07595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
T259_RS07600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
T259_RS07605	COG0598	Magnesium transport protein CorA
T259_RS07610	COG1362	aminopeptidase activity
T259_RS07625	COG0039	L-malate dehydrogenase activity
T259_RS07630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
T259_RS07640	COG0561	phosphatase activity
T259_RS07645	COG1937	Protein conserved in bacteria
T259_RS07655	COG2966	Psort location CytoplasmicMembrane, score
T259_RS07710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T259_RS07725	COG0574	Belongs to the PEP-utilizing enzyme family
T259_RS07725	COG3848	Pyruvate phosphate dikinase
T259_RS07735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
T259_RS07750	COG1115	amino acid carrier protein
T259_RS07755	COG1115	amino acid carrier protein
T259_RS07780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
T259_RS07785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
T259_RS07790	COG1959	2 iron, 2 sulfur cluster binding
T259_RS07800	COG0822	iron-sulfur transferase activity
T259_RS07810	COG0628	permease
T259_RS07835	COG0735	belongs to the Fur family
T259_RS07840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
T259_RS07845	COG1217	gtp-binding protein TYPA
T259_RS07850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
T259_RS07855	COG4122	O-methyltransferase activity
T259_RS07860	COG0826	peptidase U32
T259_RS07870	COG0768	penicillin binding
T259_RS07915	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
T259_RS07955	COG1215	transferase activity, transferring glycosyl groups
T259_RS07960	COG0849	cell division
T259_RS07965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
T259_RS07975	COG1191	sigma factor activity
T259_RS07980	COG1191	sigma factor activity
T259_RS07985	COG1873	PFAM PRC-barrel domain
T259_RS07995	COG1496	oxidoreductase activity
T259_RS08000	COG0745	RESPONSE REGULATOR receiver
T259_RS08010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
T259_RS08015	COG0573	inorganic phosphate transmembrane transporter activity
T259_RS08020	COG0581	inorganic phosphate transmembrane transporter activity
T259_RS08025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
T259_RS08030	COG0704	Plays a role in the regulation of phosphate uptake
T259_RS08050	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
T259_RS08060	COG1561	YicC-like family, N-terminal region
T259_RS08070	COG0194	GDP metabolic process
T259_RS08080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
T259_RS08085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
T259_RS08090	COG0242	peptide deformylase activity
T259_RS08100	COG2738	Putative neutral zinc metallopeptidase
T259_RS08105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T259_RS08105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T259_RS08115	COG0631	protein serine/threonine phosphatase activity
T259_RS08130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
T259_RS08155	COG1302	Protein conserved in bacteria
T259_RS08160	COG1461	Dihydroxyacetone kinase
T259_RS08165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
T259_RS08170	COG0742	ribosomal rna small subunit methyltransferase
T259_RS08195	COG3829	transcription factor binding
T259_RS08195	COG3290	protein histidine kinase activity
T259_RS08200	COG4656	Part of a membrane complex involved in electron transport
T259_RS08205	COG0252	asparaginase activity
T259_RS08205	COG5275	peptidyl-tyrosine sulfation
T259_RS08230	COG4656	Part of a membrane complex involved in electron transport
T259_RS08235	COG5275	peptidyl-tyrosine sulfation
T259_RS08235	COG0252	asparaginase activity
T259_RS08240	COG4656	Part of a membrane complex involved in electron transport
T259_RS08250	COG0252	asparaginase activity
T259_RS08250	COG5275	peptidyl-tyrosine sulfation
T259_RS08260	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
T259_RS08265	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
T259_RS08270	COG5275	peptidyl-tyrosine sulfation
T259_RS08270	COG0252	asparaginase activity
T259_RS08275	COG5275	peptidyl-tyrosine sulfation
T259_RS08275	COG0252	asparaginase activity
T259_RS08300	COG0531	amino acid
T259_RS08335	COG0252	asparaginase activity
T259_RS08335	COG5275	peptidyl-tyrosine sulfation
T259_RS08345	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
T259_RS08350	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
T259_RS08360	COG0280	phosphate acetyltransferase
T259_RS08370	COG1399	metal-binding, possibly nucleic acid-binding protein
T259_RS08375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
T259_RS08385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T259_RS08410	COG0552	protein localization to endoplasmic reticulum
T259_RS08420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
T259_RS08430	COG1837	Belongs to the UPF0109 family
T259_RS08450	COG0681	Belongs to the peptidase S26 family
T259_RS08455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T259_RS08475	COG0758	DNA mediated transformation
T259_RS08480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
T259_RS08520	COG4589	Belongs to the CDS family
T259_RS08545	COG0750	zinc metalloprotease
T259_RS08550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
T259_RS08565	COG0195	Participates in both transcription termination and antitermination
T259_RS08570	COG2740	Nucleic-acid-binding protein implicated in transcription termination
T259_RS08575	COG1358	cellular component organization or biogenesis
T259_RS08590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
T259_RS08600	COG0196	riboflavin kinase activity
T259_RS08615	COG0612	Peptidase, M16
T259_RS08625	COG0527	aspartate kinase activity
T259_RS08630	COG0740	serine-type endopeptidase activity
T259_RS08635	COG1674	ftsk spoiiie
T259_RS08645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
T259_RS08660	COG2359	stage V sporulation protein S
T259_RS08665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
T259_RS08675	COG2076	Multidrug Resistance protein
T259_RS08680	COG0436	Aminotransferase
T259_RS08685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
T259_RS08690	COG2155	Conserved Protein
T259_RS08700	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
T259_RS09025	COG3617	BRO family, N-terminal domain
T259_RS09060	COG0305	Participates in initiation and elongation during chromosome replication
T259_RS09070	COG1191	sigma factor activity
T259_RS09130	COG0863	Belongs to the N(4) N(6)-methyltransferase family
T259_RS09185	COG5484	DNA packaging
T259_RS09190	COG1783	phage Terminase large subunit
T259_RS09350	COG2801	Transposase and inactivated derivatives
T259_RS09400	COG1484	DNA-dependent DNA replication
T259_RS09420	COG0745	RESPONSE REGULATOR receiver
T259_RS09425	COG5002	protein histidine kinase activity
T259_RS09425	COG3850	Histidine kinase
T259_RS09480	COG0242	peptide deformylase activity
T259_RS09500	COG2226	methyltransferase
T259_RS09810	COG0745	RESPONSE REGULATOR receiver
T259_RS09815	COG2205	protein histidine kinase activity
T259_RS09840	COG1132	(ABC) transporter
T259_RS09845	COG1132	(ABC) transporter
T259_RS09850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
T259_RS09885	COG2856	Zn peptidase
T259_RS09890	COG1396	sequence-specific DNA binding
T259_RS09900	COG3561	AntA/AntB antirepressor
T259_RS09920	COG3723	Recombinational DNA repair protein, rece pathway
T259_RS09955	COG2002	toxin-antitoxin pair type II binding
T259_RS10025	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
T259_RS10050	COG5492	domain, Protein
T259_RS10075	COG3728	DNA packaging
T259_RS10075	COG5484	DNA packaging
T259_RS10275	COG3617	BRO family, N-terminal domain
T259_RS10310	COG0305	Participates in initiation and elongation during chromosome replication
T259_RS10320	COG1191	sigma factor activity
T259_RS10375	COG0863	Belongs to the N(4) N(6)-methyltransferase family
T259_RS10430	COG5484	DNA packaging
T259_RS10435	COG1783	phage Terminase large subunit
T259_RS10595	COG2801	Transposase and inactivated derivatives
T259_RS10705	COG3104	oligopeptide transport
T259_RS10710	COG0006	proline dipeptidase activity
T259_RS10730	COG1268	BioY protein
T259_RS10750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
T259_RS10795	COG0531	amino acid
T259_RS10805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
T259_RS10815	COG2205	protein histidine kinase activity
T259_RS10825	COG1846	Transcriptional regulator
T259_RS10830	COG2153	protein acetylation
T259_RS10835	COG4555	ABC transporter
T259_RS10840	COG1668	transmembrane transport
T259_RS10845	COG1028	Short-chain dehydrogenase reductase Sdr
T259_RS10850	COG1929	Belongs to the glycerate kinase type-1 family
T259_RS10865	COG2195	Cleaves the N-terminal amino acid of tripeptides
T259_RS10870	COG1297	OPT oligopeptide transporter protein
T259_RS10890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
T259_RS10895	COG1360	Flagellar Motor Protein
T259_RS10910	COG0489	protein tyrosine kinase activity
T259_RS10915	COG2894	cell division
T259_RS10940	COG1063	alcohol dehydrogenase
T259_RS10945	COG5599	Phosphatase
T259_RS10975	COG0456	acetyltransferase
T259_RS10980	COG1349	DNA-binding transcription factor activity
T259_RS10985	COG3395	kinase activity
T259_RS10995	COG2610	gluconate transmembrane transporter activity
T259_RS11000	COG0346	lactoylglutathione lyase activity
T259_RS11015	COG0840	transmembrane signaling receptor activity
T259_RS11050	COG1960	acyl-CoA dehydrogenase activity
T259_RS11055	COG2086	electron transfer activity
T259_RS11060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
T259_RS11075	COG0531	amino acid
T259_RS11085	COG2233	PERMEase
T259_RS11100	COG1396	sequence-specific DNA binding
T259_RS11120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T259_RS11125	COG0384	phenazine biosynthesis protein PhzF
T259_RS11135	COG1522	sequence-specific DNA binding
T259_RS11200	COG3708	Transcriptional regulator
T259_RS11200	COG2207	Transcriptional regulator
T259_RS11205	COG2226	methyltransferase
T259_RS11210	COG3104	oligopeptide transport
T259_RS11225	COG0110	maltose O-acetyltransferase activity
T259_RS11240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
T259_RS11250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
T259_RS11255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T259_RS11270	COG3711	transcriptional antiterminator
T259_RS11270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T259_RS11280	COG1136	(ABC) transporter
T259_RS11285	COG0577	efflux transmembrane transporter activity
T259_RS11290	COG0577	efflux transmembrane transporter activity
T259_RS11295	COG4555	ABC transporter
T259_RS11310	COG0745	RESPONSE REGULATOR receiver
T259_RS11315	COG2205	protein histidine kinase activity
T259_RS11330	COG1063	alcohol dehydrogenase
T259_RS11340	COG3655	Transcriptional regulator
T259_RS11355	COG3764	Sortase (surface protein transpeptidase)
T259_RS11370	COG3878	Protein conserved in bacteria
T259_RS11390	COG2186	Transcriptional regulator
T259_RS11395	COG2807	transmembrane transport
T259_RS11400	COG0534	Mate efflux family protein
T259_RS11410	COG0789	Transcriptional regulator
T259_RS11440	COG1454	alcohol dehydrogenase
T259_RS11440	COG1012	belongs to the aldehyde dehydrogenase family
T259_RS11445	COG1882	Formate acetyltransferase
T259_RS11450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
T259_RS11480	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
T259_RS11495	COG1012	belongs to the aldehyde dehydrogenase family
T259_RS11495	COG1454	alcohol dehydrogenase
T259_RS11500	COG4869	propanediol catabolic process
T259_RS11525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
T259_RS11565	COG1216	Glycosyl transferase, family 2
T259_RS11570	COG1215	transferase activity, transferring glycosyl groups
T259_RS11575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
T259_RS11615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T259_RS11640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
T259_RS11645	COG0402	S-adenosylhomocysteine deaminase activity
T259_RS11705	COG1045	serine acetyltransferase
T259_RS11740	COG4716	Myosin-crossreactive antigen
T259_RS11745	COG0714	Associated with various cellular activities
T259_RS11750	COG1653	transport
T259_RS11755	COG2304	oxidoreductase activity
T259_RS11775	COG0733	neurotransmitter:sodium symporter activity
T259_RS11790	COG2801	Transposase and inactivated derivatives
T259_RS11800	COG0006	proline dipeptidase activity
T259_RS11810	COG3104	oligopeptide transport
T259_RS11895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
T259_RS11900	COG3875	lactate racemase activity
T259_RS11905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T259_RS11910	COG0765	amino acid transport
T259_RS11915	COG1126	abc transporter atp-binding protein
T259_RS11920	COG0436	Aminotransferase
T259_RS11925	COG0697	spore germination
T259_RS11930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T259_RS11935	COG2340	Cysteine-rich secretory protein family
T259_RS11945	COG3829	transcription factor binding
T259_RS11955	COG3706	GGDEF domain
T259_RS11965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
T259_RS11970	COG0673	inositol 2-dehydrogenase activity
T259_RS11980	COG3457	Alanine racemase
T259_RS11990	COG0840	transmembrane signaling receptor activity
T259_RS12035	COG1105	Belongs to the carbohydrate kinase PfkB family
T259_RS12040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T259_RS12040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T259_RS12040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T259_RS12045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T259_RS12045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T259_RS12045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T259_RS12050	COG2188	Transcriptional regulator
T259_RS12055	COG0366	Alpha amylase catalytic
T259_RS12060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS12060	COG1263	PTS System
T259_RS12065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
T259_RS12075	COG3263	regulation of cellular component size
T259_RS12110	COG0814	amino acid
T259_RS12115	COG0697	spore germination
T259_RS12125	COG3457	Alanine racemase
T259_RS12135	COG4172	Belongs to the ABC transporter superfamily
T259_RS12140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
T259_RS12155	COG0745	RESPONSE REGULATOR receiver
T259_RS12160	COG5002	protein histidine kinase activity
T259_RS12180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
T259_RS12190	COG4545	Glutaredoxin-related protein
T259_RS12195	COG0251	oxidation-reduction process
T259_RS12200	COG4545	Glutaredoxin-related protein
T259_RS12230	COG4978	Transcriptional regulator
T259_RS12230	COG0789	Transcriptional regulator
T259_RS12240	COG1132	(ABC) transporter
T259_RS12245	COG2267	carboxylic ester hydrolase activity
T259_RS12255	COG0577	efflux transmembrane transporter activity
T259_RS12260	COG1136	(ABC) transporter
T259_RS12295	COG0521	Mo-molybdopterin cofactor biosynthetic process
T259_RS12300	COG0303	'Molybdopterin
T259_RS12305	COG1910	domain protein
T259_RS12315	COG0315	cyclic pyranopterin monophosphate synthase activity
T259_RS12330	COG2414	aldehyde ferredoxin oxidoreductase
T259_RS12345	COG0456	acetyltransferase
T259_RS12360	COG1132	(ABC) transporter
T259_RS12390	COG5002	protein histidine kinase activity
T259_RS12405	COG5002	protein histidine kinase activity
T259_RS12425	COG0840	transmembrane signaling receptor activity
T259_RS12435	COG0076	glutamate decarboxylase activity
T259_RS12475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
T259_RS12480	COG1459	type II secretion system
T259_RS12505	COG0515	serine threonine protein kinase
T259_RS12545	COG2165	general secretion pathway protein
T259_RS12605	COG3854	ATPases associated with a variety of cellular activities
T259_RS12675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
T259_RS12680	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
T259_RS12690	COG1438	arginine binding
T259_RS12695	COG0497	DNA recombination
T259_RS12700	COG2873	o-acetylhomoserine
T259_RS12705	COG0460	homoserine dehydrogenase
T259_RS12710	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
T259_RS12715	COG0750	zinc metalloprotease
T259_RS12720	COG0745	RESPONSE REGULATOR receiver
T259_RS12725	COG4974	Belongs to the 'phage' integrase family
T259_RS12805	COG4974	Belongs to the 'phage' integrase family
T259_RS12810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
T259_RS12815	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
T259_RS12835	COG1686	Belongs to the peptidase S11 family
T259_RS12845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
T259_RS12855	COG3874	Sporulation protein YtfJ
T259_RS12865	COG1686	Belongs to the peptidase S11 family
T259_RS12870	COG0628	permease
T259_RS12880	COG0589	response to stress
T259_RS12880	COG0475	glutathione-regulated potassium exporter activity
T259_RS12900	COG0488	(ABC) transporter
T259_RS12940	COG0309	Hydrogenase expression formation protein (HypE)
T259_RS12960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
T259_RS12970	COG0393	Putative heavy-metal-binding
T259_RS12985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T259_RS12990	COG0475	glutathione-regulated potassium exporter activity
T259_RS12990	COG0569	domain protein
T259_RS13000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T259_RS13010	COG4232	protein-disulfide reductase activity
T259_RS13015	COG0840	transmembrane signaling receptor activity
T259_RS13025	COG1215	transferase activity, transferring glycosyl groups
T259_RS13040	COG1187	pseudouridine synthase activity
T259_RS13045	COG1737	Transcriptional regulator
T259_RS13055	COG2081	HI0933 family
T259_RS13070	COG0539	negative regulation of cytoplasmic translation
T259_RS13070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
T259_RS13085	COG0436	Aminotransferase
T259_RS13095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T259_RS13125	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
T259_RS13140	COG4974	Belongs to the 'phage' integrase family
T259_RS13160	COG3314	Sporulation integral membrane protein YlbJ
T259_RS13170	COG2201	protein-glutamate methylesterase activity
T259_RS13185	COG1528	Iron-storage protein
T259_RS13190	COG1705	Flagellar rod assembly protein muramidase FlgJ
T259_RS13210	COG2996	Protein conserved in bacteria
T259_RS13220	COG0835	chemotaxis
T259_RS13220	COG0784	Response regulator, receiver
T259_RS13230	COG0488	(ABC) transporter
T259_RS13245	COG2340	Cysteine-rich secretory protein family
T259_RS13250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T259_RS13275	COG3104	oligopeptide transport
T259_RS13280	COG1105	Belongs to the carbohydrate kinase PfkB family
T259_RS13290	COG1309	transcriptional regulator
T259_RS13295	COG2814	Major facilitator Superfamily
T259_RS13300	COG0071	Belongs to the small heat shock protein (HSP20) family
T259_RS13310	COG4086	secreted protein
T259_RS13315	COG1199	ATP-dependent helicase activity
T259_RS13315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
T259_RS13325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T259_RS13350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T259_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
T259_RS13380	COG0840	transmembrane signaling receptor activity
T259_RS13385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
T259_RS13425	COG5492	domain, Protein
T259_RS13445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
T259_RS13445	COG0493	'glutamate synthase
T259_RS13465	COG0460	homoserine dehydrogenase
T259_RS13470	COG0527	aspartate kinase activity
T259_RS13485	COG1174	glycine betaine transport
T259_RS13490	COG0517	IMP dehydrogenase activity
T259_RS13490	COG1125	glycine betaine transport
T259_RS13495	COG0095	Lipoate-protein ligase
T259_RS13500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T259_RS13505	COG0508	dehydrogenase complex catalyzes the overall conversion of
T259_RS13515	COG0022	dehydrogenase e1 component
T259_RS13520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
T259_RS13545	COG1410	methionine synthase
T259_RS13545	COG0646	methionine synthase
T259_RS13555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
T259_RS13580	COG1349	DNA-binding transcription factor activity
T259_RS13585	COG0561	phosphatase activity
T259_RS13590	COG2707	UPF0756 membrane protein
T259_RS13640	COG1263	PTS System
T259_RS13640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS13640	COG2190	(PTS) system
T259_RS13645	COG0366	Alpha amylase catalytic
T259_RS13650	COG1940	carbohydrate kinase activity
T259_RS13655	COG1609	Transcriptional regulator
T259_RS13660	COG1132	(ABC) transporter
T259_RS13665	COG1132	(ABC) transporter
T259_RS13665	COG2375	cellular response to nickel ion
T259_RS13670	COG2207	Transcriptional regulator
T259_RS13670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T259_RS13685	COG2801	Transposase and inactivated derivatives
T259_RS13735	COG2235	arginine
T259_RS13760	COG1131	(ABC) transporter
T259_RS13765	COG2391	methyltransferase activity
T259_RS13770	COG0446	pyridine nucleotide-disulphide oxidoreductase
T259_RS13780	COG0583	DNA-binding transcription factor activity
T259_RS13785	COG2391	methyltransferase activity
T259_RS13795	COG2391	methyltransferase activity
T259_RS13825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
T259_RS13835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
T259_RS13850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T259_RS13865	COG5278	phosphoserine phosphatase activity
T259_RS13865	COG0840	transmembrane signaling receptor activity
T259_RS13880	COG0602	queuosine metabolic process
T259_RS13885	COG0720	synthase
T259_RS13890	COG1924	4 iron, 4 sulfur cluster binding
T259_RS13900	COG0697	spore germination
T259_RS13905	COG2378	regulation of single-species biofilm formation
T259_RS13930	COG1131	(ABC) transporter
T259_RS13935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T259_RS13955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T259_RS13960	COG1408	metallophosphoesterase
T259_RS13965	COG1639	'signal transduction protein
T259_RS13975	COG1132	(ABC) transporter
T259_RS13980	COG1132	(ABC) transporter
T259_RS13980	COG2375	cellular response to nickel ion
T259_RS13985	COG2207	Transcriptional regulator
T259_RS13985	COG1917	Cupin 2, conserved barrel domain protein
T259_RS14005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
T259_RS14010	COG3620	sequence-specific DNA binding
T259_RS14015	COG5564	TIM-barrel signal transduction protein
T259_RS14025	COG5564	TIM-barrel signal transduction protein
T259_RS14030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
T259_RS14045	COG1733	regulation of RNA biosynthetic process
T259_RS14070	COG0840	transmembrane signaling receptor activity
T259_RS14100	COG2186	Transcriptional regulator
T259_RS14115	COG0395	ABC-type sugar transport system, permease component
T259_RS14125	COG3842	ATPase activity
T259_RS14135	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
T259_RS14140	COG0667	Aldo Keto reductase
T259_RS14145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
T259_RS14155	COG0723	plastoquinol--plastocyanin reductase activity
T259_RS14155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T259_RS14165	COG0446	pyridine nucleotide-disulphide oxidoreductase
T259_RS14165	COG1902	pentaerythritol trinitrate reductase activity
T259_RS14175	COG1464	Belongs to the NlpA lipoprotein family
T259_RS14180	COG2011	ABC-type metal ion transport system permease component
T259_RS14185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T259_RS14190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
T259_RS14195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
T259_RS14200	COG5012	cobalamin binding
T259_RS14210	COG0523	cobalamin synthesis protein
T259_RS14220	COG1757	Na H antiporter
T259_RS14225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
T259_RS14235	COG1752	Esterase of the alpha-beta hydrolase superfamily
T259_RS14245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
T259_RS14250	COG4149	molybdate abc transporter
T259_RS14255	COG0725	ABC transporter, periplasmic molybdate-binding protein
T259_RS14265	COG0116	Belongs to the methyltransferase superfamily
T259_RS14270	COG0708	Exodeoxyribonuclease III
T259_RS14275	COG2233	PERMEase
T259_RS14280	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
T259_RS14285	COG0564	pseudouridine synthase activity
T259_RS14290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
T259_RS14295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
T259_RS14305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
T259_RS14305	COG1605	Chorismate mutase
T259_RS14310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
T259_RS14320	COG3599	regulation of cell shape
T259_RS14340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
T259_RS14350	COG3856	small basic protein
T259_RS14365	COG0772	Belongs to the SEDS family
T259_RS14370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T259_RS14375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T259_RS14385	COG0768	penicillin binding
T259_RS14400	COG2001	Belongs to the MraZ family
T259_RS14405	COG0012	GTP binding
T259_RS14410	COG1272	protein, Hemolysin III
T259_RS14430	COG0157	Belongs to the NadC ModD family
T259_RS14470	COG1067	ATP-dependent peptidase activity
T259_RS14495	COG2244	polysaccharide biosynthetic process
T259_RS14505	COG0860	N-Acetylmuramoyl-L-alanine amidase
T259_RS14510	COG1473	amidohydrolase
T259_RS14515	COG0849	cell division
T259_RS14525	COG0210	DNA helicase
T259_RS14660	COG4626	Terminase
T259_RS14660	COG1802	Transcriptional regulator
T259_RS14790	COG4974	Belongs to the 'phage' integrase family
T259_RS14805	COG0765	amino acid transport
T259_RS14810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T259_RS14815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
T259_RS14820	COG1288	antiporter activity
T259_RS14830	COG1979	alcohol dehydrogenase
T259_RS14840	COG0494	nUDIX hydrolase
T259_RS14845	COG1686	Belongs to the peptidase S11 family
T259_RS14860	COG2801	Transposase and inactivated derivatives
T259_RS14865	COG1126	abc transporter atp-binding protein
T259_RS14875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
T259_RS14890	COG0577	efflux transmembrane transporter activity
T259_RS14895	COG1136	(ABC) transporter
T259_RS14900	COG2205	protein histidine kinase activity
T259_RS14905	COG0745	RESPONSE REGULATOR receiver
T259_RS14915	COG0577	efflux transmembrane transporter activity
T259_RS14920	COG1136	(ABC) transporter
T259_RS14925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T259_RS14930	COG0351	phosphomethylpyrimidine kinase
T259_RS14940	COG2195	Cleaves the N-terminal amino acid of tripeptides
T259_RS14945	COG1278	Cold shock
T259_RS14975	COG1131	(ABC) transporter
T259_RS14980	COG2197	response regulator
T259_RS14985	COG4585	Histidine kinase
T259_RS15000	COG1234	tRNA 3'-trailer cleavage
T259_RS15020	COG0735	belongs to the Fur family
T259_RS15025	COG1116	anion transmembrane transporter activity
T259_RS15040	COG3706	GGDEF domain
T259_RS15055	COG0803	Belongs to the bacterial solute-binding protein 9 family
T259_RS15060	COG1121	(ABC) transporter
T259_RS15065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T259_RS15075	COG4608	Belongs to the ABC transporter superfamily
T259_RS15080	COG0444	Belongs to the ABC transporter superfamily
T259_RS15085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T259_RS15090	COG0601	transmembrane transport
T259_RS15100	COG5278	phosphoserine phosphatase activity
T259_RS15100	COG0840	transmembrane signaling receptor activity
T259_RS15140	COG2207	Transcriptional regulator
T259_RS15140	COG3708	Transcriptional regulator
T259_RS15150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS15150	COG1263	PTS System
T259_RS15160	COG1737	Transcriptional regulator
T259_RS15175	COG1120	ATPase activity
T259_RS15180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS15185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T259_RS15195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T259_RS15205	COG1132	(ABC) transporter
T259_RS15215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
T259_RS15225	COG1151	hydroxylamine reductase activity
T259_RS15250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
T259_RS15255	COG1263	PTS System
T259_RS15255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS15255	COG2190	(PTS) system
T259_RS15260	COG2247	cell wall binding repeat
T259_RS15260	COG2385	sporulation resulting in formation of a cellular spore
T259_RS15275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T259_RS15300	COG0569	domain protein
T259_RS15310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
T259_RS15350	COG1132	(ABC) transporter
T259_RS15355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T259_RS15360	COG2608	mercury ion transmembrane transporter activity
T259_RS15365	COG2217	Heavy metal translocating P-type atpase
T259_RS15370	COG1937	Protein conserved in bacteria
T259_RS15395	COG1215	transferase activity, transferring glycosyl groups
T259_RS15400	COG5298	Protein conserved in bacteria
T259_RS15410	COG1115	amino acid carrier protein
T259_RS15415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
T259_RS15420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
T259_RS15445	COG0590	tRNA wobble adenosine to inosine editing
T259_RS15450	COG2080	2 iron, 2 sulfur cluster binding
T259_RS15455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
T259_RS15460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T259_RS15515	COG2323	membrane
T259_RS15520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
T259_RS15530	COG2376	Dihydroxyacetone kinase
T259_RS15535	COG1349	DNA-binding transcription factor activity
T259_RS15545	COG0235	Class ii aldolase
T259_RS15550	COG1879	ABC-type sugar transport system periplasmic component
T259_RS15560	COG1172	Belongs to the binding-protein-dependent transport system permease family
T259_RS15565	COG1129	ABC transporter
T259_RS15575	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
T259_RS15620	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
T259_RS15625	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
T259_RS15645	COG1012	belongs to the aldehyde dehydrogenase family
T259_RS15680	COG1115	amino acid carrier protein
T259_RS15700	COG1131	(ABC) transporter
T259_RS15710	COG1309	transcriptional regulator
T259_RS15745	COG0756	dUTP diphosphatase activity
T259_RS15765	COG4632	Exopolysaccharide biosynthesis protein
T259_RS15765	COG5434	Belongs to the glycosyl hydrolase 28 family
T259_RS15770	COG3546	catalase activity
T259_RS15790	COG0601	transmembrane transport
T259_RS15795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T259_RS15800	COG1136	(ABC) transporter
T259_RS15810	COG0577	efflux transmembrane transporter activity
T259_RS15810	COG1136	(ABC) transporter
T259_RS15825	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
T259_RS15840	COG0840	transmembrane signaling receptor activity
T259_RS15845	COG1760	l-serine dehydratase
T259_RS15855	COG5001	Diguanylate cyclase
T259_RS15855	COG3300	MHYT domain
T259_RS15885	COG1131	(ABC) transporter
T259_RS15895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
T259_RS15910	COG1940	carbohydrate kinase activity
T259_RS15970	COG3290	protein histidine kinase activity
T259_RS15990	COG1606	tRNA processing
T259_RS16015	COG1959	2 iron, 2 sulfur cluster binding
T259_RS16040	COG0561	phosphatase activity
T259_RS16050	COG3404	Formiminotransferase-cyclodeaminase
T259_RS16055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
T259_RS16065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T259_RS16070	COG0697	spore germination
T259_RS16080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T259_RS16085	COG4120	Belongs to the binding-protein-dependent transport system permease family
T259_RS16100	COG0824	Thioesterase
T259_RS16105	COG0539	negative regulation of cytoplasmic translation
T259_RS16105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
T259_RS16125	COG3842	ATPase activity
T259_RS16160	COG0628	permease
T259_RS16170	COG2897	thiosulfate sulfurtransferase activity
T259_RS16200	COG1054	Belongs to the UPF0176 family
T259_RS16205	COG1335	isochorismatase
T259_RS16220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
T259_RS16240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
T259_RS16250	COG2239	Acts as a magnesium transporter
T259_RS16265	COG5002	protein histidine kinase activity
T259_RS16285	COG0110	maltose O-acetyltransferase activity
T259_RS16290	COG2431	L-lysine efflux transmembrane transporter activity
T259_RS16305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T259_RS16315	COG3842	ATPase activity
T259_RS16320	COG1176	ABC-type spermidine putrescine transport system, permease component I
T259_RS16330	COG4134	Bacterial extracellular solute-binding protein
T259_RS16345	COG0534	Mate efflux family protein
T259_RS16350	COG1846	Transcriptional regulator
T259_RS16355	COG1115	amino acid carrier protein
T259_RS16360	COG1115	amino acid carrier protein
T259_RS16365	COG1012	belongs to the aldehyde dehydrogenase family
T259_RS16370	COG0617	tRNA 3'-terminal CCA addition
T259_RS16380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
T259_RS16400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T259_RS16405	COG2186	Transcriptional regulator
T259_RS16425	COG1473	amidohydrolase
T259_RS16430	COG1464	Belongs to the NlpA lipoprotein family
T259_RS16435	COG1464	Belongs to the NlpA lipoprotein family
T259_RS16440	COG2011	ABC-type metal ion transport system permease component
T259_RS16445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T259_RS16455	COG3979	chitinase
T259_RS16490	COG2239	Acts as a magnesium transporter
T259_RS16495	COG0436	Aminotransferase
T259_RS16510	COG2271	Major facilitator Superfamily
T259_RS16520	COG0446	pyridine nucleotide-disulphide oxidoreductase
T259_RS16530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
T259_RS16545	COG0488	(ABC) transporter
T259_RS16565	COG4129	membrane
T259_RS16570	COG1331	Highly conserved protein containing a thioredoxin domain
T259_RS16595	COG3279	Response regulator of the LytR AlgR family
T259_RS16605	COG1132	(ABC) transporter
T259_RS16610	COG2207	Transcriptional regulator
T259_RS16615	COG4607	ABC-type enterochelin transport system periplasmic component
T259_RS16620	COG4604	ABC transporter, ATP-binding protein
T259_RS16625	COG4605	iron ion homeostasis
T259_RS16630	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS16645	COG5002	protein histidine kinase activity
T259_RS16650	COG0745	RESPONSE REGULATOR receiver
T259_RS16670	COG2124	cytochrome p450
T259_RS16680	COG5002	protein histidine kinase activity
T259_RS16695	COG1876	peptidase activity
T259_RS16715	COG1918	ferrous iron import across plasma membrane
T259_RS16715	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
T259_RS16725	COG0456	acetyltransferase
T259_RS16730	COG0583	DNA-binding transcription factor activity
T259_RS16775	COG0017	Asparaginyl-tRNA synthetase
T259_RS16785	COG0789	Transcriptional regulator
T259_RS16785	COG4978	Transcriptional regulator
T259_RS16790	COG1846	Transcriptional regulator
T259_RS16800	COG0436	Aminotransferase
T259_RS16825	COG0277	FAD linked oxidase domain protein
T259_RS16830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
T259_RS16835	COG2086	electron transfer activity
T259_RS16840	COG3875	lactate racemase activity
T259_RS16845	COG1620	l-lactate permease
T259_RS16855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T259_RS16860	COG0602	queuosine metabolic process
T259_RS16880	COG0745	RESPONSE REGULATOR receiver
T259_RS16885	COG0622	Phosphoesterase
T259_RS16890	COG1773	rubredoxin
T259_RS16890	COG1592	Rubrerythrin
T259_RS16895	COG0514	ATP-dependent DNA helicase (RecQ)
T259_RS16925	COG1876	peptidase activity
T259_RS16935	COG5002	protein histidine kinase activity
T259_RS16970	COG0656	L-ascorbic acid biosynthetic process
T259_RS16985	COG0454	-acetyltransferase
T259_RS16990	COG2207	Transcriptional regulator
T259_RS16990	COG0662	Cupin 2, conserved barrel domain protein
T259_RS17000	COG2376	Dihydroxyacetone kinase
T259_RS17010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS17015	COG1120	ATPase activity
T259_RS17020	COG2205	protein histidine kinase activity
T259_RS17025	COG0745	RESPONSE REGULATOR receiver
T259_RS17070	COG2116	formate transmembrane transporter activity
T259_RS17080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
T259_RS17120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
T259_RS17120	COG1648	precorrin-2 dehydrogenase activity
T259_RS17180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
T259_RS17180	COG0456	acetyltransferase
T259_RS17190	COG0778	Nitroreductase
T259_RS17195	COG0454	-acetyltransferase
T259_RS17235	COG0113	porphobilinogen synthase activity
T259_RS17255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
T259_RS17255	COG1648	precorrin-2 dehydrogenase activity
T259_RS17275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
T259_RS17300	COG0789	Transcriptional regulator
T259_RS17315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
T259_RS17320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T259_RS17330	COG1268	BioY protein
T259_RS17335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
T259_RS17340	COG5002	protein histidine kinase activity
T259_RS17350	COG0577	efflux transmembrane transporter activity
T259_RS17350	COG1136	(ABC) transporter
T259_RS17360	COG2801	Transposase and inactivated derivatives
T259_RS17380	COG1376	ErfK ybiS ycfS ynhG family protein
T259_RS17450	COG2207	Transcriptional regulator
T259_RS17450	COG3708	Transcriptional regulator
T259_RS17470	COG0778	Nitroreductase
T259_RS17475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T259_RS17490	COG1733	regulation of RNA biosynthetic process
T259_RS17520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T259_RS17525	COG2378	regulation of single-species biofilm formation
T259_RS17530	COG2378	regulation of single-species biofilm formation
T259_RS17540	COG0519	Catalyzes the synthesis of GMP from XMP
T259_RS17545	COG0583	DNA-binding transcription factor activity
T259_RS17555	COG1611	Belongs to the LOG family
T259_RS17560	COG2140	Oxalate decarboxylase
T259_RS17570	COG0778	Nitroreductase
T259_RS17575	COG1733	regulation of RNA biosynthetic process
T259_RS17590	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
T259_RS17590	COG0456	acetyltransferase
T259_RS17595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T259_RS17630	COG2267	carboxylic ester hydrolase activity
T259_RS17650	COG1131	(ABC) transporter
T259_RS17675	COG1595	DNA-templated transcription, initiation
T259_RS17690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
T259_RS17695	COG0789	Transcriptional regulator
T259_RS17700	COG0071	Belongs to the small heat shock protein (HSP20) family
T259_RS17705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
T259_RS17705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
T259_RS17715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
T259_RS17720	COG0720	synthase
T259_RS17760	COG2720	vancomycin resistance protein
T259_RS17765	COG0406	alpha-ribazole phosphatase activity
T259_RS17770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
T259_RS17775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
T259_RS17790	COG1114	Component of the transport system for branched-chain amino acids
T259_RS17795	COG1228	amidohydrolase
T259_RS17810	COG0346	lactoylglutathione lyase activity
T259_RS17815	COG4974	Belongs to the 'phage' integrase family
T259_RS17825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T259_RS17845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
T259_RS17860	COG1120	ATPase activity
T259_RS17865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS17870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS17875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T259_RS17885	COG3850	Histidine kinase
T259_RS17885	COG5002	protein histidine kinase activity
T259_RS17905	COG1136	(ABC) transporter
T259_RS17920	COG2205	protein histidine kinase activity
T259_RS17925	COG2207	Transcriptional regulator
T259_RS17925	COG3708	Transcriptional regulator
T259_RS17940	COG0745	RESPONSE REGULATOR receiver
T259_RS17950	COG1131	(ABC) transporter
T259_RS17965	COG0352	thiamine-phosphate diphosphorylase activity
T259_RS17965	COG0351	phosphomethylpyrimidine kinase
T259_RS17995	COG1131	(ABC) transporter
T259_RS18060	COG1396	sequence-specific DNA binding
T259_RS18090	COG1733	regulation of RNA biosynthetic process
T259_RS18105	COG2226	methyltransferase
T259_RS18110	COG0626	cystathionine gamma-synthase activity
T259_RS18115	COG1854	S-ribosylhomocysteine lyase activity
T259_RS18120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T259_RS18140	COG0488	(ABC) transporter
T259_RS18160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T259_RS18175	COG1476	TRANSCRIPTIONal
T259_RS18180	COG0697	spore germination
T259_RS18195	COG0789	Transcriptional regulator
T259_RS18200	COG4185	zeta toxin
T259_RS18210	COG0095	Lipoate-protein ligase
T259_RS18215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T259_RS18220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
T259_RS18225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
T259_RS18250	COG0840	transmembrane signaling receptor activity
T259_RS18260	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
T259_RS18265	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
T259_RS18270	COG1120	ATPase activity
T259_RS18275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS18280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T259_RS18310	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
T259_RS18360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
T259_RS18365	COG2112	serine threonine protein kinase
T259_RS18385	COG4120	Belongs to the binding-protein-dependent transport system permease family
T259_RS18415	COG0786	glutamate:sodium symporter activity
T259_RS18440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T259_RS18445	COG0613	PHP domain protein
T259_RS18450	COG1263	PTS System
T259_RS18450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T259_RS18450	COG2190	(PTS) system
T259_RS18455	COG3711	transcriptional antiterminator
T259_RS18465	COG0494	nUDIX hydrolase
T259_RS18475	COG2949	membrane
T259_RS18490	COG0583	DNA-binding transcription factor activity
T259_RS18500	COG2814	Major facilitator Superfamily
T259_RS18515	COG0513	Belongs to the DEAD box helicase family
T259_RS18530	COG1193	negative regulation of DNA recombination
T259_RS18535	COG0346	lactoylglutathione lyase activity
T259_RS18545	COG1396	sequence-specific DNA binding
T259_RS18550	COG2207	Transcriptional regulator
T259_RS18555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T259_RS18575	COG1132	(ABC) transporter
T259_RS18585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
T259_RS18590	COG0772	Belongs to the SEDS family
T259_RS18600	COG0784	Response regulator, receiver
T259_RS18620	COG3279	Response regulator of the LytR AlgR family
T259_RS18625	COG5002	protein histidine kinase activity
T259_RS18635	COG1876	peptidase activity
T259_RS18655	COG0740	serine-type endopeptidase activity
T259_RS18670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
T259_RS18680	COG1368	sulfuric ester hydrolase activity
T259_RS18695	COG1307	EDD domain protein, DegV family
T259_RS18715	COG1136	(ABC) transporter
T259_RS18735	COG1132	(ABC) transporter
T259_RS18775	COG3279	Response regulator of the LytR AlgR family
T259_RS18790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T259_RS18790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T259_RS18795	COG1357	PFAM Pentapeptide repeats (8 copies)
T259_RS18820	COG3409	Peptidoglycan-binding domain 1 protein
T259_RS18845	COG1301	dicarboxylic acid transport
T259_RS18860	COG1695	Transcriptional regulator
T259_RS18865	COG1177	transmembrane transport
T259_RS18875	COG3842	ATPase activity
T259_RS18880	COG0840	transmembrane signaling receptor activity
T259_RS18890	COG1131	(ABC) transporter
T259_RS18895	COG1725	Transcriptional regulator
T259_RS18900	COG0653	protein targeting
T259_RS18920	COG0488	(ABC) transporter
T259_RS18935	COG1966	Carbon starvation protein
T259_RS18945	COG1073	alpha beta
T259_RS18975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T259_RS18990	COG0006	proline dipeptidase activity
T259_RS19010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T259_RS19010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T259_RS19020	COG2337	Toxic component of a toxin-antitoxin (TA) module
T259_RS19025	COG2059	Chromate
T259_RS19030	COG2059	Chromate
T259_RS19040	COG2333	competence protein COMEC
T259_RS19040	COG0658	competence protein
T259_RS19050	COG0531	amino acid
T259_RS19055	COG0531	amino acid
T259_RS19065	COG1522	sequence-specific DNA binding
T259_RS19075	COG0531	amino acid
T259_RS19105	COG2703	oxygen carrier activity
T259_RS19135	COG1199	ATP-dependent helicase activity
T259_RS19140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
T259_RS19145	COG2204	response regulator
T259_RS19150	COG0840	transmembrane signaling receptor activity
T259_RS19160	COG0745	RESPONSE REGULATOR receiver
T259_RS19165	COG2267	carboxylic ester hydrolase activity
T259_RS19175	COG2205	protein histidine kinase activity
T259_RS19175	COG0784	Response regulator, receiver
T259_RS19180	COG1028	Short-chain dehydrogenase reductase Sdr
T259_RS19185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
T259_RS19215	COG1994	Peptidase M50
T259_RS19230	COG1131	(ABC) transporter
T259_RS19270	COG2801	Transposase and inactivated derivatives
T259_RS19280	COG5434	Belongs to the glycosyl hydrolase 28 family
T259_RS19280	COG4632	Exopolysaccharide biosynthesis protein
T259_RS19285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
T259_RS19315	COG2217	Heavy metal translocating P-type atpase
T259_RS19320	COG0640	Transcriptional regulator
T259_RS19325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T259_RS19335	COG0419	ATPase involved in DNA repair
T259_RS19340	COG0420	3'-5' exonuclease activity
T259_RS19350	COG3655	Transcriptional regulator
T259_RS19355	COG2226	methyltransferase
T259_RS19375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
T259_RS19390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T259_RS19440	COG0351	phosphomethylpyrimidine kinase
T259_RS19440	COG0352	thiamine-phosphate diphosphorylase activity
T259_RS19455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
T259_RS19460	COG2226	methyltransferase
T259_RS19465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T259_RS19470	COG0765	amino acid transport
T259_RS19505	COG1752	Esterase of the alpha-beta hydrolase superfamily
T259_RS19515	COG0840	transmembrane signaling receptor activity
T259_RS19515	COG3290	protein histidine kinase activity
T259_RS19540	COG0375	protein maturation
T259_RS19595	COG2155	Conserved Protein
T259_RS19600	COG1757	Na H antiporter
T259_RS19605	COG1126	abc transporter atp-binding protein
T259_RS19610	COG0473	3-isopropylmalate dehydrogenase activity
T259_RS19620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
T259_RS19630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
T259_RS19665	COG1968	undecaprenyl-diphosphatase activity
T259_RS19675	COG1482	cell wall glycoprotein biosynthetic process
T259_RS19680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T259_RS19685	COG3442	glutamine amidotransferase
T259_RS19740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T259_RS19745	COG0840	transmembrane signaling receptor activity
T259_RS19755	COG0457	Tetratricopeptide repeat
T259_RS19755	COG0705	Rhomboid family
T259_RS19780	COG0629	single-stranded DNA binding
T259_RS19800	COG0531	amino acid
T259_RS19820	COG0573	inorganic phosphate transmembrane transporter activity
T259_RS19825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
T259_RS19840	COG2385	sporulation resulting in formation of a cellular spore
T259_RS19840	COG2247	cell wall binding repeat
T259_RS19865	COG1477	protein flavinylation
T259_RS19885	COG1245	4Fe-4S binding domain
T259_RS19885	COG2878	Part of a membrane complex involved in electron transport
T259_RS19890	COG4657	Part of a membrane complex involved in electron transport
T259_RS19895	COG4660	Part of a membrane complex involved in electron transport
T259_RS19900	COG4659	FMN binding
T259_RS19905	COG4658	electron transport chain
T259_RS19910	COG4656	Part of a membrane complex involved in electron transport
T259_RS19915	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
T259_RS19920	COG5002	protein histidine kinase activity
T259_RS21425	COG1215	transferase activity, transferring glycosyl groups
T259_RS21430	COG1396	sequence-specific DNA binding
T259_RS21455	COG0305	Participates in initiation and elongation during chromosome replication
T259_RS21465	COG1396	sequence-specific DNA binding