locus-tag class description GNZ07_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GNZ07_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNZ07_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNZ07_RS00070 ENOG4108Z3G 3H domain protein GNZ07_RS00140 ENOG4108RDQ ABC transporter GNZ07_RS00185 ENOG4105C28 cystathionine GNZ07_RS00190 ENOG4108Z6B deaminase GNZ07_RS00205 ENOG4105C6E dna polymerase iii GNZ07_RS00235 ENOG4105E09 nadh pyrophosphatase GNZ07_RS00255 ENOG4105CUZ uba thif-type nad fad binding protein GNZ07_RS00265 ENOG4105D9U N-acetyltransferase GNZ07_RS00380 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GNZ07_RS00400 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GNZ07_RS00410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GNZ07_RS00435 ENOG4105CXN decarboxylase GNZ07_RS00445 ENOG4105X0R protein from nitrogen regulatory protein P-II GNZ07_RS00450 ENOG4107XK4 dna polymerase iii subunits gamma and tau GNZ07_RS00455 ENOG4105MA4 psp1 domain protein GNZ07_RS00470 ENOG41060K3 Methyltransferase GNZ07_RS00475 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GNZ07_RS00480 ENOG4107SN7 NLP P60 protein GNZ07_RS00485 ENOG4105KRN Transcriptional regulator, abrb family GNZ07_RS00505 ENOG4107BJW polysaccharide deacetylase GNZ07_RS00515 ENOG4108JIC nucleoside recognition domain protein GNZ07_RS00525 ENOG4105UQX Mate efflux family protein GNZ07_RS00530 ENOG4108UN4 phage SPO1 DNA polymerase-related protein GNZ07_RS00540 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GNZ07_RS00545 ENOG4108UH6 UPF0754 membrane protein GNZ07_RS00550 ENOG4105F8V Hydrolase, tatD family GNZ07_RS00555 ENOG41069ER domain protein GNZ07_RS00590 ENOG4105C19 ABC transporter GNZ07_RS00595 ENOG4107RBB ABC transporter, permease GNZ07_RS00605 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein GNZ07_RS00615 ENOG4105BZU Histidine kinase GNZ07_RS00620 ENOG4105KT7 mgtC SapB transporter GNZ07_RS00625 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GNZ07_RS00645 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein GNZ07_RS00650 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GNZ07_RS00665 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GNZ07_RS00670 ENOG4105C8M UPF0272 protein GNZ07_RS00680 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase GNZ07_RS00695 ENOG4108TJN glycosyl transferase group 1 GNZ07_RS00700 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) GNZ07_RS00720 ENOG4108TJN glycosyl transferase group 1 GNZ07_RS00730 ENOG4105XFA sporulation peptidase YabG GNZ07_RS00735 ENOG4105W42 Veg protein GNZ07_RS00745 ENOG4105DDG Cyanophycinase GNZ07_RS00770 ENOG4108Q8B Spore germination protein GNZ07_RS00780 ENOG4108ZXQ stage ii sporulation protein r GNZ07_RS00785 ENOG4108QBV Monogalactosyldiacylglycerol synthase GNZ07_RS00790 ENOG4105MSI germination protein ypeb GNZ07_RS00810 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GNZ07_RS00820 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GNZ07_RS00835 ENOG4105CBJ Metal-dependent enzyme GNZ07_RS00860 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GNZ07_RS00865 ENOG4107WAU Protein tyrosine phosphatase GNZ07_RS00870 ENOG4108YZG isomerase GNZ07_RS00890 ENOG4105ESV Glycosyl transferase, family 4 GNZ07_RS00895 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GNZ07_RS00905 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GNZ07_RS00950 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GNZ07_RS00965 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GNZ07_RS00975 ENOG4108ZDA Sporulation protein YyaC GNZ07_RS00980 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GNZ07_RS01015 ENOG4105C7H Helicase, RecD TraA family GNZ07_RS01055 ENOG4108SAX Membrane GNZ07_RS01080 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GNZ07_RS01100 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GNZ07_RS01115 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GNZ07_RS01135 ENOG4105D2N Aldolase GNZ07_RS01145 ENOG4105H67 Protein of unknown function (DUF421) GNZ07_RS01150 ENOG4105C22 threonyL-tRNA synthetase GNZ07_RS01155 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GNZ07_RS01160 ENOG41080XP Cbs domain GNZ07_RS01165 ENOG4105CBD Diacylglycerol kinase GNZ07_RS01185 ENOG4105C6T cysteine synthase GNZ07_RS01190 ENOG4105D7W serine acetyltransferase GNZ07_RS01195 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GNZ07_RS01205 ENOG4105CSM endonuclease III GNZ07_RS01210 ENOG4105C6K Malic enzyme GNZ07_RS01225 ENOG4105DER m42 family GNZ07_RS01230 ENOG41073R8 VanW family GNZ07_RS01235 ENOG41073R8 VanW family GNZ07_RS01240 ENOG4105F6S Spore photoproduct lyase GNZ07_RS01245 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GNZ07_RS01250 ENOG4105EPR degv family GNZ07_RS01255 ENOG4105DIH basic membrane GNZ07_RS01260 ENOG4108JQ9 ABC transporter GNZ07_RS01265 ENOG4105UIB (ABC) transporter GNZ07_RS01280 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNZ07_RS01320 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GNZ07_RS01345 ENOG4105CK1 PTS System GNZ07_RS01350 ENOG4105F8D glycoside hydrolase family 4 GNZ07_RS01360 ENOG4105VCP PTS System GNZ07_RS01380 ENOG41063TF transcriptional regulator (AraC GNZ07_RS01390 ENOG4105I03 Flagellin GNZ07_RS01400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNZ07_RS01420 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GNZ07_RS01430 ENOG4108IQI permease GNZ07_RS01455 ENOG4105NAE bifunctional deaminase-reductase domain protein GNZ07_RS01460 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GNZ07_RS01490 ENOG4105CZ3 stage V sporulation protein ad GNZ07_RS01495 ENOG41090VF Stage v sporulation protein ac GNZ07_RS01500 ENOG4108QG2 Membrane GNZ07_RS01520 ENOG4107QIV Cytochrome c biogenesis protein GNZ07_RS01535 ENOG4105EB3 Histidine kinase GNZ07_RS01545 ENOG4105F8D glycoside hydrolase family 4 GNZ07_RS01550 ENOG4105CI1 PTS System GNZ07_RS01555 ENOG4105HX0 Transcriptional regulator GNZ07_RS01565 ENOG4105C5Y PTS System GNZ07_RS01575 ENOG4105EWM Histidine kinase GNZ07_RS01580 ENOG4105C19 ABC transporter GNZ07_RS01590 ENOG4105CI1 PTS System GNZ07_RS01595 ENOG4105F8D glycoside hydrolase family 4 GNZ07_RS01610 ENOG4105VEQ Cold shock protein GNZ07_RS01620 ENOG4108Z40 Transcriptional regulator GNZ07_RS01625 ENOG4107ZXU DSBA oxidoreductase GNZ07_RS01630 ENOG4108RYK Nad-dependent epimerase dehydratase GNZ07_RS01635 ENOG4108Q3X Transcriptional regulator GNZ07_RS01640 ENOG4105CI1 PTS System GNZ07_RS01650 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane GNZ07_RS01655 ENOG4105C01 Dihydroxy-acid dehydratase GNZ07_RS01665 ENOG4105D7K pfkb domain protein GNZ07_RS01680 ENOG4105F3H Histidine kinase GNZ07_RS01685 ENOG4105CKK Glycosyl transferase, family 2 GNZ07_RS01695 ENOG4105EDW glycosyl transferase, family 39 GNZ07_RS01700 ENOG4105E7U AraC family transcriptional regulator GNZ07_RS01710 ENOG4105EHG Permease protein GNZ07_RS01715 ENOG4105E0A ABC, transporter GNZ07_RS01730 ENOG4108V5C ABC transporter GNZ07_RS01735 ENOG4105T16 Transcriptional regulator (AraC family) GNZ07_RS01740 ENOG4108V5C ABC transporter GNZ07_RS01745 ENOG4105DQ5 transport system permease protein GNZ07_RS01750 ENOG4105EHG Permease protein GNZ07_RS01755 ENOG4105E0A ABC, transporter GNZ07_RS01760 ENOG4105BZ1 (ABC) transporter GNZ07_RS01815 ENOG41067MG lrgb family GNZ07_RS01870 ENOG4105BZU Histidine kinase GNZ07_RS01890 ENOG4105BZU Histidine kinase GNZ07_RS01895 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GNZ07_RS01900 ENOG4105CFF transcriptional regulator GNZ07_RS01905 ENOG4105E5D amino acid GNZ07_RS01910 ENOG4105DC7 peptidase M24 GNZ07_RS01950 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNZ07_RS01955 ENOG4105BZU Histidine kinase GNZ07_RS01975 ENOG4105BZU Histidine kinase GNZ07_RS02000 ENOG4105C9B Cysteine desulfurase GNZ07_RS02005 ENOG4105HMI Membrane GNZ07_RS02025 ENOG4107RUZ Sss sodium solute transporter superfamily GNZ07_RS02030 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GNZ07_RS02035 ENOG4105D6A Electron transport complex GNZ07_RS02040 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit GNZ07_RS02045 ENOG4105DZB Electron transport complex GNZ07_RS02050 ENOG4105DGN Electron transport complex GNZ07_RS02055 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit GNZ07_RS02075 ENOG4105CJ2 (LipO)protein GNZ07_RS02110 ENOG4105CVA phosphate GNZ07_RS02115 ENOG4105C8U phosphate abc transporter GNZ07_RS02125 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GNZ07_RS02135 ENOG4107QTZ amino acid GNZ07_RS02155 ENOG4108UUM single-stranded DNA-binding protein GNZ07_RS02175 ENOG4105CPI Metal Dependent Phosphohydrolase GNZ07_RS02180 ENOG4107ZXI Rhomboid family GNZ07_RS02190 ENOG4105IU0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GNZ07_RS02230 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GNZ07_RS02235 ENOG4105F1K Glutamine amidotransferase GNZ07_RS02240 ENOG4105DMS mur ligase GNZ07_RS02245 ENOG4105DG6 mannose-6-phosphate isomerase GNZ07_RS02255 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GNZ07_RS02290 ENOG4105E8R UPF0173 metal-dependent hydrolase GNZ07_RS02300 ENOG4107SDT Homocitrate synthase GNZ07_RS02305 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GNZ07_RS02310 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GNZ07_RS02315 ENOG4105CDA abc transporter atp-binding protein GNZ07_RS02320 ENOG4107S6Z Na H antiporter GNZ07_RS02325 ENOG4105WG9 Conserved Protein GNZ07_RS02365 ENOG4108IG5 Transcriptional regulator GNZ07_RS02380 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GNZ07_RS02400 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS02430 ENOG4105E5Q amino acid AbC transporter GNZ07_RS02435 ENOG4105E89 ABC transporter GNZ07_RS02440 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNZ07_RS02445 ENOG4105D58 Diguanylate phosphodiesterase GNZ07_RS02460 ENOG4105DWF phosphomethylpyrimidine kinase GNZ07_RS02470 ENOG4105CP9 extracellular ligand-binding receptor GNZ07_RS02475 ENOG4105C32 Amino acid ABC transporter (Permease) GNZ07_RS02480 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GNZ07_RS02485 ENOG4105C0Z ABC transporter GNZ07_RS02490 ENOG4108IV0 ABC, transporter GNZ07_RS02520 ENOG4105HA9 of methanol dehydrogenase type GNZ07_RS02540 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNZ07_RS02545 ENOG4105VMP Transcriptional regulator GNZ07_RS02560 ENOG4105EYH Exonuclease GNZ07_RS02585 ENOG4105C59 p-type ATPase GNZ07_RS02615 ENOG4108IAB Phoh family GNZ07_RS02620 ENOG4108HQ0 Exopolysaccharide biosynthesis protein GNZ07_RS02660 ENOG4105CJ1 ABC, transporter GNZ07_RS02675 ENOG4108Z4T Peptidase M50 GNZ07_RS02705 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GNZ07_RS02710 ENOG4105CHR reductase GNZ07_RS02725 ENOG4105E5G Alpha beta hydrolase fold GNZ07_RS02730 ENOG4105XJC Two component transcriptional regulator (Winged helix family GNZ07_RS02735 ENOG4105CPI Metal Dependent Phosphohydrolase GNZ07_RS02740 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS02745 ENOG410812K response regulator receiver protein GNZ07_RS02750 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GNZ07_RS02755 ENOG4105DVT helicase GNZ07_RS02785 ENOG410828M hemerythrin-like, metal-binding protein GNZ07_RS02835 ENOG4105BZ1 (ABC) transporter GNZ07_RS02850 ENOG4105C19 ABC transporter GNZ07_RS02865 ENOG4105C0X amino acid GNZ07_RS02870 ENOG4108VVK transcriptional Regulator, AsnC GNZ07_RS02880 ENOG4105D5Q Arginine ornithine antiporter GNZ07_RS02885 ENOG4105D5Q Arginine ornithine antiporter GNZ07_RS02895 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GNZ07_RS02905 ENOG4105CAH Chromate GNZ07_RS02910 ENOG4105FGV Chromate GNZ07_RS02915 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GNZ07_RS02925 ENOG4108DWA Nad synthetase GNZ07_RS02940 ENOG4107RAQ aminopeptidase GNZ07_RS02980 ENOG4105D22 carbon starvation protein GNZ07_RS02995 ENOG4105C5H ABC transporter GNZ07_RS03000 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GNZ07_RS03015 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GNZ07_RS03020 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GNZ07_RS03025 ENOG4105CZV ABC transporter GNZ07_RS03050 ENOG4105D38 putrescine abc transporter GNZ07_RS03060 ENOG4107QJT sodium dicarboxylate symporter GNZ07_RS03105 ENOG4105DDN Pentapeptide repeat-containing protein GNZ07_RS03110 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GNZ07_RS03130 ENOG4105DY9 regulatoR GNZ07_RS03185 ENOG4105BZ1 (ABC) transporter GNZ07_RS03205 ENOG4105C19 ABC transporter GNZ07_RS03225 ENOG4105EPR degv family GNZ07_RS03235 ENOG4105E0M Sulfatase GNZ07_RS03245 ENOG4105D9N nucleoside GNZ07_RS03275 ENOG41086D8 Transcriptional regulator GNZ07_RS03295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS03300 ENOG4105C08 Histidine kinase GNZ07_RS03305 ENOG4108VXD carboxy-peptidase GNZ07_RS03315 ENOG4105BZU Histidine kinase GNZ07_RS03330 ENOG4105BZU Histidine kinase GNZ07_RS03335 ENOG4105CNI cell division protein FtsW GNZ07_RS03340 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GNZ07_RS03350 ENOG4105BZ1 (ABC) transporter GNZ07_RS03360 ENOG41062JF Transcriptional regulator GNZ07_RS03370 ENOG4108Z7R Chaperone CsaA GNZ07_RS03375 ENOG4105CF7 AraC family transcriptional regulator GNZ07_RS03380 ENOG4108IMY Transcriptional regulator GNZ07_RS03405 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GNZ07_RS03410 ENOG4108UYE Lactoylglutathione lyase GNZ07_RS03415 ENOG4105C98 muts2 protein GNZ07_RS03435 ENOG4105WD1 Membrane GNZ07_RS03455 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNZ07_RS03465 ENOG4105C1J atp-dependent rna helicase GNZ07_RS03510 ENOG4108UB4 uncharacterized protein ygjQ GNZ07_RS03515 ENOG4108F3G Type I restriction-modification system, R subunit GNZ07_RS03520 ENOG4105M6F mutator MutT protein GNZ07_RS03540 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GNZ07_RS03550 ENOG4105CID antiterminator GNZ07_RS03555 ENOG4105C5Y PTS System GNZ07_RS03560 ENOG4105DB7 PHP domain protein GNZ07_RS03565 ENOG4105IJJ transcriptional regulator, crp fnr family GNZ07_RS03570 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center GNZ07_RS03575 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GNZ07_RS03610 ENOG4105C7J ABC transporter, permease GNZ07_RS03615 ENOG4108JJB ABC transporter GNZ07_RS03660 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GNZ07_RS03690 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GNZ07_RS03710 ENOG4105DQ5 transport system permease protein GNZ07_RS03715 ENOG4105EHG Permease protein GNZ07_RS03720 ENOG4105E0A ABC, transporter GNZ07_RS03730 ENOG4105D0B Nitrogenase protein alpha chain GNZ07_RS03740 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS03765 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GNZ07_RS03770 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GNZ07_RS03780 ENOG4105DF9 Lipoate-protein, ligase GNZ07_RS03800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS03805 ENOG4105BZU Histidine kinase GNZ07_RS03810 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GNZ07_RS03830 ENOG4108DMH HTH_ARAC GNZ07_RS03850 ENOG4105VZ8 Transcriptional regulator GNZ07_RS03870 ENOG4105W1Y Transcriptional regulator GNZ07_RS03895 ENOG4105EEM helicase GNZ07_RS03910 ENOG41086D8 Transcriptional regulator GNZ07_RS03930 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GNZ07_RS03935 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS03945 ENOG4105C5H ABC transporter GNZ07_RS03970 ENOG4105C28 cystathionine GNZ07_RS03975 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNZ07_RS03985 ENOG4108I0C methyltransferase GNZ07_RS03995 ENOG41086D8 Transcriptional regulator GNZ07_RS04020 ENOG4108IMY Transcriptional regulator GNZ07_RS04105 ENOG4105D6J arsenicaL-resistance protein GNZ07_RS04200 ENOG4105DWF phosphomethylpyrimidine kinase GNZ07_RS04215 ENOG4105CJ1 ABC, transporter GNZ07_RS04225 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNZ07_RS04240 ENOG41086D8 Transcriptional regulator GNZ07_RS04260 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GNZ07_RS04275 ENOG4105BZU Histidine kinase GNZ07_RS04285 ENOG4108MES Periplasmic binding protein GNZ07_RS04290 ENOG4105DQ5 transport system permease protein GNZ07_RS04295 ENOG4108IHU transport system permease protein GNZ07_RS04300 ENOG4105E0A ABC, transporter GNZ07_RS04315 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GNZ07_RS04320 ENOG4105KHC sulfurtransferase GNZ07_RS04400 ENOG4105CI2 imidazolone-5-propionate hydrolase GNZ07_RS04410 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS04420 ENOG4105CE1 Ferrous iron transport protein b GNZ07_RS04425 ENOG4105CE1 Ferrous iron transport protein b GNZ07_RS04430 ENOG4105CVJ phosphoglycerate mutase GNZ07_RS04435 ENOG41073R8 VanW family GNZ07_RS04470 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GNZ07_RS04475 ENOG4105EEI dihydropteroate synthase GNZ07_RS04485 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GNZ07_RS04490 ENOG4107Y70 Heat shock protein GNZ07_RS04495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNZ07_RS04500 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GNZ07_RS04515 ENOG4105JVQ RNA Polymerase GNZ07_RS04540 ENOG4105CJ1 ABC, transporter GNZ07_RS04545 ENOG41067QW Transcriptional regulator GNZ07_RS04560 ENOG4107S9D Alpha beta hydrolase GNZ07_RS04590 ENOG4105RHY Pfam:UPF0157 GNZ07_RS04610 ENOG4105KVH Transcriptional regulator GNZ07_RS04615 ENOG4108TVJ Nitroreductase GNZ07_RS04630 ENOG4108URH decarboxylase GNZ07_RS04645 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GNZ07_RS04655 ENOG4105D29 Helix-turn-helix type 11 domain protein GNZ07_RS04675 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GNZ07_RS04680 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNZ07_RS04685 ENOG4105HFT AraC family transcriptional regulator GNZ07_RS04690 ENOG4108TVJ Nitroreductase GNZ07_RS04705 ENOG4105CID antiterminator GNZ07_RS04710 ENOG4105C5Y PTS System GNZ07_RS04715 ENOG4105CS2 ec 3.2.1.21 GNZ07_RS04725 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GNZ07_RS04775 ENOG4105T2N Domain of unknown function (DUF2382) GNZ07_RS04780 ENOG4108MTT Glutamate-rich protein grpB GNZ07_RS04785 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GNZ07_RS04820 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GNZ07_RS04830 ENOG4105BZU Histidine kinase GNZ07_RS04835 ENOG4105CM2 brancheD-chain amino acid aminotransferase GNZ07_RS04840 ENOG4107ZYJ bioY protein GNZ07_RS04855 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GNZ07_RS04870 ENOG4107TXC Transcriptional regulator GNZ07_RS04880 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GNZ07_RS04885 ENOG4105CIH Imidazole acetol-phosphate transaminase GNZ07_RS04890 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GNZ07_RS04925 ENOG4105D52 delta-aminolevulinic acid dehydratase GNZ07_RS04930 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GNZ07_RS04935 ENOG41081F0 Precorrin-8x methylmutase GNZ07_RS04960 ENOG4105VEV -acetyltransferase GNZ07_RS04970 ENOG4107Y03 Nitroreductase GNZ07_RS05005 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase GNZ07_RS05045 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GNZ07_RS05050 ENOG4105CIA precorrin-4 C(11)-methyltransferase GNZ07_RS05055 ENOG4108P62 biosynthesis protein (CbiG) GNZ07_RS05060 ENOG4105E4R Precorrin-3B C17-methyltransferase GNZ07_RS05065 ENOG4108JTQ reductase GNZ07_RS05075 ENOG4107PPM cobalt chelatase GNZ07_RS05080 ENOG4105JZC GHMP kinase GNZ07_RS05085 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GNZ07_RS05095 ENOG4107V9H nitrite transporter GNZ07_RS05100 ENOG4105D5B Sulfite reductase, subunit A GNZ07_RS05105 ENOG4107SHJ sulfite reductase subunit b GNZ07_RS05110 ENOG410810Y Sulfite reductase GNZ07_RS05140 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNZ07_RS05150 ENOG4105E0A ABC, transporter GNZ07_RS05155 ENOG4105EHG Permease protein GNZ07_RS05160 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GNZ07_RS05170 ENOG4105PAD Hydrolase GNZ07_RS05190 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GNZ07_RS05215 ENOG4105CMT Dihydroxyacetone kinase GNZ07_RS05225 ENOG4105FTV AraC Family Transcriptional Regulator GNZ07_RS05230 ENOG4108HYG acetyltransferase GNZ07_RS05280 ENOG4105BZU Histidine kinase GNZ07_RS05290 ENOG4108UZE carboxy-peptidase GNZ07_RS05320 ENOG4105C9U ATP-dependent DNA helicase RecQ GNZ07_RS05325 ENOG4105KY8 Rubrerythrin GNZ07_RS05330 ENOG4108RE9 Phosphodiesterase GNZ07_RS05335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS05355 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GNZ07_RS05375 ENOG4105QUH Domain of unknown function (DUF2088) GNZ07_RS05380 ENOG4105BZJ Electron transfer flavoprotein GNZ07_RS05385 ENOG4105C10 Electron transfer flavoprotein GNZ07_RS05390 ENOG4105CQB FAD linked oxidase domain protein GNZ07_RS05410 ENOG4105CHM Aminotransferase GNZ07_RS05420 ENOG4108INS Transcriptional regulator GNZ07_RS05425 ENOG4108Z5V transcriptional regulator, merr family GNZ07_RS05435 ENOG4105C5S asparaginyl-tRNA synthetase GNZ07_RS05465 ENOG4105PAD Hydrolase GNZ07_RS05480 ENOG4107V2S Transcriptional regulator GNZ07_RS05485 ENOG4105EPI acetyltransferase, (GNAT) family GNZ07_RS05495 ENOG4105CE1 Ferrous iron transport protein b GNZ07_RS05515 ENOG4108VXD carboxy-peptidase GNZ07_RS05530 ENOG4105BZU Histidine kinase GNZ07_RS05535 ENOG4107E6A Cytochrome p-450 GNZ07_RS05550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS05555 ENOG4105BZU Histidine kinase GNZ07_RS05565 ENOG4105E7U AraC family transcriptional regulator GNZ07_RS05570 ENOG4105DHS permease protein GNZ07_RS05575 ENOG4105CM4 permease protein GNZ07_RS05580 ENOG4108IPW abc transporter atp-binding protein GNZ07_RS05595 ENOG4105BZ1 (ABC) transporter GNZ07_RS05600 ENOG4105BZ1 (ABC) transporter GNZ07_RS05610 ENOG4105DY9 regulatoR GNZ07_RS05640 ENOG4105C7Z Conserved Protein GNZ07_RS05645 ENOG4108QEG Membrane GNZ07_RS05675 ENOG4105C5H ABC transporter GNZ07_RS05710 ENOG4105CXY transporter GNZ07_RS05725 ENOG4105CJW magnesium transporter GNZ07_RS05735 ENOG4105CE1 Ferrous iron transport protein b GNZ07_RS05755 ENOG4108NNZ chitinase GNZ07_RS05765 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GNZ07_RS05770 ENOG4108UMI ABC transporter, permease GNZ07_RS05775 ENOG4105D01 (LipO)protein GNZ07_RS05800 ENOG4105JXH GntR family transcriptional regulator GNZ07_RS05825 ENOG4105CY0 Metallo-Beta-Lactamase GNZ07_RS05835 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GNZ07_RS05840 ENOG4105C26 Dehydrogenase GNZ07_RS05855 ENOG4108U05 Transcriptional regulator GNZ07_RS05860 ENOG4105C3S Mate efflux family protein GNZ07_RS05875 ENOG4105VNH ABC transporter solute-binding protein GNZ07_RS05885 ENOG4105F38 ABC transporter, permease GNZ07_RS05915 ENOG4105DWU Membrane GNZ07_RS05920 ENOG4108UW5 maltose o-acetyltransferase GNZ07_RS05940 ENOG4105BZU Histidine kinase GNZ07_RS05950 ENOG4105CJW magnesium transporter GNZ07_RS05960 ENOG4108JQ1 Dehydrogenase GNZ07_RS05970 ENOG4105CNW domain protein GNZ07_RS05980 ENOG4105C94 Transporter GNZ07_RS05995 ENOG4108RWI nicotinamidase GNZ07_RS06000 ENOG4105C72 UPF0176 protein GNZ07_RS06030 ENOG4107RM6 sulfurtransferase GNZ07_RS06040 ENOG4105C02 permease GNZ07_RS06075 ENOG4107RCV ABC transporter, permease GNZ07_RS06095 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GNZ07_RS06100 ENOG41082UD thioesterase Superfamily protein GNZ07_RS06115 ENOG4105C7J ABC transporter, permease GNZ07_RS06120 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GNZ07_RS06130 ENOG4105CEB Aspartate aminotransferase GNZ07_RS06135 ENOG4108IPJ Membrane GNZ07_RS06140 ENOG4105DD7 kinase (PfkB family GNZ07_RS06150 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GNZ07_RS06155 ENOG410908R Methenyltetrahydrofolate cyclohydrolase GNZ07_RS06165 ENOG4105DQF Hydrolase GNZ07_RS06195 ENOG4105C6T cysteine synthase GNZ07_RS06200 ENOG4105E5Q amino acid AbC transporter GNZ07_RS06205 ENOG4105EAB amino acid AbC transporter GNZ07_RS06250 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GNZ07_RS06295 ENOG4105DKQ ROK family GNZ07_RS06310 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GNZ07_RS06320 ENOG4105DVE abc transporter atp-binding protein GNZ07_RS06350 ENOG4105BZU Histidine kinase GNZ07_RS06360 ENOG4105EJQ L-serine dehydratase GNZ07_RS06380 ENOG4108U5J '-nucleotidase GNZ07_RS06385 ENOG4105C42 Type I secretion membrane fusion protein (HlyD GNZ07_RS06405 ENOG4108IGT Dipeptidase GNZ07_RS06415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GNZ07_RS06425 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GNZ07_RS06430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNZ07_RS06455 ENOG4105WEF catalase GNZ07_RS06460 ENOG4108HQ0 Exopolysaccharide biosynthesis protein GNZ07_RS06510 ENOG4108IG5 Transcriptional regulator GNZ07_RS06550 ENOG41067QW Transcriptional regulator GNZ07_RS06575 ENOG4105C26 Dehydrogenase GNZ07_RS06590 ENOG4105EZ5 reductase GNZ07_RS06640 ENOG4108KU3 Integrase GNZ07_RS06740 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain GNZ07_RS06745 ENOG4106GRJ chromatin binding GNZ07_RS06775 ENOG41061CV Terminase small subunit GNZ07_RS06840 ENOG4105PQS phage protein GNZ07_RS06845 ENOG4105FR7 XkdM protein, phage-like element PBSX GNZ07_RS06885 ENOG41066EA baseplate J family protein GNZ07_RS06960 ENOG4105FB2 class II Aldolase GNZ07_RS06965 ENOG4105E98 transcriptional regulator DeoR family GNZ07_RS06980 ENOG4108QY0 Membrane GNZ07_RS07040 ENOG4105C7W Xanthine dehydrogenase GNZ07_RS07045 ENOG4108HR6 Dehydrogenase GNZ07_RS07050 ENOG4108UTP (2Fe-2S)-binding domain protein GNZ07_RS07055 ENOG4107Y2X deaminase GNZ07_RS07060 ENOG4105C9U ATP-dependent DNA helicase RecQ GNZ07_RS07080 ENOG4105CN5 Metallo-Beta-Lactamase GNZ07_RS07085 ENOG4105BZG amino acid carrier protein GNZ07_RS07095 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GNZ07_RS07100 ENOG4107R8N Glycosyl transferase, family 2 GNZ07_RS07130 ENOG4105C59 p-type ATPase GNZ07_RS07140 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GNZ07_RS07145 ENOG4105BZ1 (ABC) transporter GNZ07_RS07165 ENOG4105BZU Histidine kinase GNZ07_RS07275 ENOG4105C1A potassium transporter peripheral membrane GNZ07_RS07280 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GNZ07_RS07285 ENOG4105C4R Atp-dependent dna helicase GNZ07_RS07285 ENOG4105C4R Atp-dependent dna helicase GNZ07_RS07295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNZ07_RS07310 ENOG4105JFG SpoIID LytB domain protein GNZ07_RS07320 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GNZ07_RS07335 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit GNZ07_RS07345 ENOG4107SJS nitrite reductase, (NAD(P)H) GNZ07_RS07350 ENOG4105EFQ Two component transcriptional regulator (Winged helix family GNZ07_RS07360 ENOG4107WD8 ABC transporter, permease GNZ07_RS07375 ENOG4105BZ1 (ABC) transporter GNZ07_RS07380 ENOG4105BZ1 (ABC) transporter GNZ07_RS07385 ENOG4105VXR cytoplasmic protein GNZ07_RS07390 ENOG4108W3Y Transcriptional regulator, Crp Fnr family GNZ07_RS07405 ENOG4105EHG Permease protein GNZ07_RS07410 ENOG4105E0A ABC, transporter GNZ07_RS07420 ENOG4105WCA Ferredoxin GNZ07_RS07425 ENOG4106KNT transcriptional regulator GNZ07_RS07475 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS07490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNZ07_RS07495 ENOG4108RZA ABC transporter GNZ07_RS07500 ENOG4108JQ7 (ABC) transporter GNZ07_RS07510 ENOG4105FAV ABC, transporter GNZ07_RS07515 ENOG4105FDK ABC transporter GNZ07_RS07520 ENOG4105DSE periplasmic solute binding protein GNZ07_RS07535 ENOG4105BZU Histidine kinase GNZ07_RS07550 ENOG4105D7T ABC transporter GNZ07_RS07555 ENOG4105G5W regulator Fur family GNZ07_RS07570 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GNZ07_RS07575 ENOG4107R7I amino acid GNZ07_RS07580 ENOG4105KWG Pfam:DUF1696 GNZ07_RS07585 ENOG4105BZU Histidine kinase GNZ07_RS07590 ENOG4105WH1 Two component transcriptional regulator luxr family GNZ07_RS07595 ENOG4105CJ1 ABC, transporter GNZ07_RS07625 ENOG4105VEQ Cold shock protein GNZ07_RS07630 ENOG4105CIN aminoacyl-histidine dipeptidase GNZ07_RS07645 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GNZ07_RS07695 ENOG4105C87 Aminotransferase class I and II GNZ07_RS07700 ENOG4105EAB amino acid AbC transporter GNZ07_RS07705 ENOG4105E5Q amino acid AbC transporter GNZ07_RS07720 ENOG4105DZ1 carboxypeptidase GNZ07_RS07735 ENOG4107QW4 alcohol dehydrogenase GNZ07_RS07745 ENOG4105CSX c4-dicarboxylate anaerobic carrier GNZ07_RS07750 ENOG4105DAP Nicotinate phosphoribosyltransferase GNZ07_RS07755 ENOG4105CT1 (ABC) transporter GNZ07_RS07760 ENOG4105E5Q amino acid AbC transporter GNZ07_RS07780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GNZ07_RS07785 ENOG4105CH2 amidohydrolase GNZ07_RS07790 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNZ07_RS07795 ENOG4105C34 Pseudouridine synthase GNZ07_RS07825 ENOG4105DAN ATP-dependent protease GNZ07_RS07860 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GNZ07_RS07880 ENOG4108UT2 hemolysin iii GNZ07_RS07885 ENOG4105C3G gtp-binding protein GNZ07_RS07890 ENOG4108V6E Cell division protein mraZ GNZ07_RS07905 ENOG4105CJN penicillin-binding protein GNZ07_RS07915 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GNZ07_RS07920 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GNZ07_RS07925 ENOG4105CNI cell division protein FtsW GNZ07_RS07940 ENOG4105K67 small basic protein GNZ07_RS07950 ENOG4105DFA alanine racemase domain protein GNZ07_RS07960 ENOG4108VIA integral membrane protein GNZ07_RS07970 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GNZ07_RS07975 ENOG4105D49 3-dehydroquinate synthase GNZ07_RS07980 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GNZ07_RS07985 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GNZ07_RS07990 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GNZ07_RS08000 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GNZ07_RS08005 ENOG4105C34 Pseudouridine synthase GNZ07_RS08010 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GNZ07_RS08020 ENOG4105CGK Exodeoxyribonuclease III GNZ07_RS08025 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GNZ07_RS08035 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GNZ07_RS08040 ENOG4105E0C molybdate abc transporter GNZ07_RS08045 ENOG4108IJ6 ABC transporter GNZ07_RS08065 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GNZ07_RS08070 ENOG4105DFD Na H antiporter GNZ07_RS08080 ENOG4105CKI cobalamin synthesis protein GNZ07_RS08090 ENOG4108Q52 Methyltransferase cognate corrinoid protein GNZ07_RS08095 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GNZ07_RS08105 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GNZ07_RS08110 ENOG4108UMI ABC transporter, permease GNZ07_RS08115 ENOG4105D01 (LipO)protein GNZ07_RS08125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GNZ07_RS08130 ENOG4105CU9 asparagine synthetase A GNZ07_RS08140 ENOG4105C9U ATP-dependent DNA helicase RecQ GNZ07_RS08145 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GNZ07_RS08150 ENOG4105CPC Aldo Keto reductase GNZ07_RS08155 ENOG4108ZQX ybak prolyl-trna synthetase GNZ07_RS08165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GNZ07_RS08175 ENOG4105DRS transport system, permease GNZ07_RS08190 ENOG4105JXH GntR family transcriptional regulator GNZ07_RS08205 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GNZ07_RS08215 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS08230 ENOG4105KVH Transcriptional regulator GNZ07_RS08240 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GNZ07_RS08250 ENOG4105EQN UPF0261 protein GNZ07_RS08290 ENOG4108HU6 Metal dependent phosphohydrolase GNZ07_RS08300 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GNZ07_RS08325 ENOG4105WH1 Two component transcriptional regulator luxr family GNZ07_RS08335 ENOG4105D29 Helix-turn-helix type 11 domain protein GNZ07_RS08345 ENOG4105CIZ coA-substrate-specific enzyme activase GNZ07_RS08350 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GNZ07_RS08355 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GNZ07_RS08390 ENOG4107RHR regulatoR GNZ07_RS08400 ENOG4108RVA ribokinase GNZ07_RS08415 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GNZ07_RS08425 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GNZ07_RS08455 ENOG4105CUC YeeE YedE family protein GNZ07_RS08465 ENOG41066VF YeeE YedE family protein GNZ07_RS08470 ENOG4105DUM transcriptional regulator, lysR family GNZ07_RS08480 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GNZ07_RS08485 ENOG4105CUC YeeE YedE family protein GNZ07_RS08490 ENOG4105DA5 (ABC) transporter GNZ07_RS08515 ENOG4105CEU Arginine dihydrolase GNZ07_RS08525 ENOG4108UT2 hemolysin iii GNZ07_RS08545 ENOG4105EKQ RNA-directed DNA polymerase GNZ07_RS08575 ENOG410874W AraC family transcriptional regulator GNZ07_RS08580 ENOG4105BZ1 (ABC) transporter GNZ07_RS08585 ENOG4105BZ1 (ABC) transporter GNZ07_RS08590 ENOG4105FKQ transcriptional regulator GNZ07_RS08595 ENOG4105E2R ROK family GNZ07_RS08605 ENOG4105CI1 PTS System GNZ07_RS08620 ENOG4105EGD dinuclear metal center protein, YbgI family GNZ07_RS08655 ENOG410667J hydrolase GNZ07_RS08660 ENOG4105E98 transcriptional regulator DeoR family GNZ07_RS08680 ENOG4105SYT Methylenetetrahydrofolate reductase GNZ07_RS08690 ENOG4105C3R Methionine synthase GNZ07_RS08720 ENOG4107RUY (E1 component), alpha subunit GNZ07_RS08730 ENOG4106Z86 ATP-nad acox kinase GNZ07_RS08735 ENOG4105C7S Dehydrogenase GNZ07_RS08745 ENOG4105DF9 Lipoate-protein, ligase GNZ07_RS08760 ENOG4107QID Threonine synthase GNZ07_RS08770 ENOG4105CFH Aspartokinase GNZ07_RS08775 ENOG4105D6E homoserine dehydrogenase GNZ07_RS08795 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein GNZ07_RS08800 ENOG4105BZ8 glutamate synthase GNZ07_RS08815 ENOG4108J53 cell adhesion domain-containing protein GNZ07_RS08855 ENOG4108JUA Transcriptional regulator GNZ07_RS08870 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GNZ07_RS08875 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GNZ07_RS08895 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS08915 ENOG4108R96 Methyltransferase, YaeB family GNZ07_RS08925 ENOG4108J59 Extracellular solute-binding protein, family 5 GNZ07_RS08930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GNZ07_RS08935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNZ07_RS08945 ENOG4105DVT helicase GNZ07_RS08950 ENOG4105PTM secreted protein GNZ07_RS08965 ENOG4105DE4 1-phosphofructokinase GNZ07_RS08970 ENOG4105DUX Transporter GNZ07_RS08995 ENOG4105DD7 kinase (PfkB family GNZ07_RS09000 ENOG4105K4I Scp-like extracellular GNZ07_RS09010 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GNZ07_RS09015 ENOG4105C5H ABC transporter GNZ07_RS09020 ENOG410810Y Sulfite reductase GNZ07_RS09025 ENOG4107R88 Chemotaxis protein (CheV) GNZ07_RS09035 ENOG4105QNR S1 RNA binding domain protein GNZ07_RS09040 ENOG4105C1J atp-dependent rna helicase GNZ07_RS09055 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GNZ07_RS09060 ENOG41090A1 ferritin GNZ07_RS09065 ENOG4107YTP response regulator receiver protein GNZ07_RS09075 ENOG4105DWD nucleoside recognition domain protein GNZ07_RS09095 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNZ07_RS09110 ENOG4105CXI aluminum resistance protein GNZ07_RS09140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNZ07_RS09150 ENOG4105CHM Aminotransferase GNZ07_RS09165 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GNZ07_RS09180 ENOG4105CBX hi0933 family GNZ07_RS09185 ENOG4105D82 Glutamate dehydrogenase GNZ07_RS09190 ENOG4106G6Q Transcriptional regulator GNZ07_RS09195 ENOG4105FE9 pseudouridine synthase GNZ07_RS09220 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS09225 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GNZ07_RS09265 ENOG4108115 UPF0145 protein GNZ07_RS09275 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD GNZ07_RS09295 ENOG4105C45 hydrogenase expression formation protein (HypE) GNZ07_RS09300 ENOG4105CQS hydrogenase expression formation protein HypD GNZ07_RS09305 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF GNZ07_RS09325 ENOG4105DPX Hydrogenase, large subunit GNZ07_RS09330 ENOG4105E3S small subunit GNZ07_RS09375 ENOG4105C5H ABC transporter GNZ07_RS09380 ENOG4107QHI -hydrogenase GNZ07_RS09385 ENOG4107QIZ NADH dehydrogenase GNZ07_RS09390 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit GNZ07_RS09410 ENOG4105DZ1 carboxypeptidase GNZ07_RS09420 ENOG4105KBJ sporulation protein ytfj GNZ07_RS09430 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GNZ07_RS09440 ENOG4105DZ1 carboxypeptidase GNZ07_RS09460 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GNZ07_RS09465 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GNZ07_RS09470 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNZ07_RS09485 ENOG4107SC7 Inner membrane transporter yjeM GNZ07_RS09560 ENOG4107QQR Sporulation GNZ07_RS09565 ENOG4105S1Z Stage IV sporulation protein B GNZ07_RS09575 ENOG4105D6E homoserine dehydrogenase GNZ07_RS09585 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GNZ07_RS09600 ENOG4105DX0 Hemolysin A GNZ07_RS09605 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GNZ07_RS09660 ENOG4105KQ4 Stage iii sporulation protein ad GNZ07_RS09665 ENOG4108CQH stage III sporulation protein AC GNZ07_RS09675 ENOG4105CD2 stage iii sporulation protein aa GNZ07_RS09735 ENOG4108VAU general secretion pathway protein G GNZ07_RS09740 ENOG4105D7Q type ii secretion system GNZ07_RS09745 ENOG4107QHF type ii secretion system protein e GNZ07_RS09780 ENOG4105CVK Glutamate decarboxylase GNZ07_RS09790 ENOG4105EC8 Methyl-accepting chemotaxis GNZ07_RS09810 ENOG4105BZU Histidine kinase GNZ07_RS09825 ENOG4105BZU Histidine kinase GNZ07_RS09845 ENOG4105CJ1 ABC, transporter GNZ07_RS09850 ENOG4105BZ1 (ABC) transporter GNZ07_RS09880 ENOG4105WE2 aldehyde ferredoxin oxidoreductase GNZ07_RS09895 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GNZ07_RS09905 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GNZ07_RS09910 ENOG4105CVM Molybdenum cofactor synthesis domain protein GNZ07_RS09915 ENOG4108RIR Molybdenum cofactor biosynthesis protein GNZ07_RS09935 ENOG4105UQX Mate efflux family protein GNZ07_RS09955 ENOG4107WD8 ABC transporter, permease GNZ07_RS09965 ENOG4107S9D Alpha beta hydrolase GNZ07_RS09970 ENOG4105BZ1 (ABC) transporter GNZ07_RS09980 ENOG41090E6 transcriptional regulator MERR family GNZ07_RS10020 ENOG4105BZU Histidine kinase GNZ07_RS10025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS10035 ENOG4108W7F transporter, permease GNZ07_RS10040 ENOG4108JJB ABC transporter GNZ07_RS10050 ENOG4106M28 alanine racemase domain protein GNZ07_RS10055 ENOG4108B31 Spore germination protein GNZ07_RS10060 ENOG4105E1K spore germination protein GNZ07_RS10100 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GNZ07_RS10110 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GNZ07_RS10115 ENOG4105C5Y PTS System GNZ07_RS10120 ENOG4105CG3 alpha amylase, catalytic region GNZ07_RS10125 ENOG4107414 GntR family transcriptional regulator GNZ07_RS10130 ENOG4105DM4 PTS System GNZ07_RS10135 ENOG4105DM4 PTS System GNZ07_RS10140 ENOG4106VEM tagatose-6-phosphate kinase GNZ07_RS10145 ENOG4105D2N Aldolase GNZ07_RS10155 ENOG4105G7B Protein of unknown function (DUF2992) GNZ07_RS10175 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS10180 ENOG4106M28 alanine racemase domain protein GNZ07_RS10190 ENOG4105D9R oxidoreductase GNZ07_RS10195 ENOG4107QV3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GNZ07_RS10205 ENOG4105BZU Histidine kinase GNZ07_RS10215 ENOG4108JUB Transcriptional regulator GNZ07_RS10220 ENOG4105C1J atp-dependent rna helicase GNZ07_RS10225 ENOG4105K4I Scp-like extracellular GNZ07_RS10235 ENOG4105SX7 Transporter GNZ07_RS10245 ENOG4105CDA abc transporter atp-binding protein GNZ07_RS10250 ENOG4105E5Q amino acid AbC transporter GNZ07_RS10255 ENOG4108HW3 (ABC) transporter GNZ07_RS10265 ENOG4105C5R Aminotransferase GNZ07_RS10305 ENOG4105DUX Transporter GNZ07_RS10310 ENOG4105DUX Transporter GNZ07_RS10315 ENOG4105DC7 peptidase M24 GNZ07_RS10330 ENOG4105C8J )-transporter GNZ07_RS10365 ENOG4105CCI Myosin-Cross-Reactive Antigen GNZ07_RS10385 ENOG4108N3W hemolysin secretion protein GNZ07_RS10410 ENOG4105D7W serine acetyltransferase GNZ07_RS10425 ENOG4107V9E glucose-1-phosphate thymidylyltransferase GNZ07_RS10470 ENOG4105DZC cytosine deaminase GNZ07_RS10475 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GNZ07_RS10510 ENOG4105DZR Type I site-specific deoxyribonuclease GNZ07_RS10515 ENOG4105F0V Cell wall hydrolase GNZ07_RS10535 ENOG4105C1B dTDP-glucose 4-6-dehydratase GNZ07_RS10545 ENOG4107S6X Glycosyl transferase, family 2 GNZ07_RS10585 ENOG4105KNY Microcompartments protein GNZ07_RS10590 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) GNZ07_RS10595 ENOG4105C0A alcohol dehydrogenase GNZ07_RS10600 ENOG4105KNY Microcompartments protein GNZ07_RS10605 ENOG4105NDK ethanolamine utilization protein GNZ07_RS10620 ENOG4107YMV ethanolamine utilization protein GNZ07_RS10630 ENOG4105KTW ethanolamine utilization protein GNZ07_RS10635 ENOG4105M3W utilization protein GNZ07_RS10640 ENOG4105F1A Pyruvate formate-lyase GNZ07_RS10645 ENOG4105C6N Formate acetyltransferase GNZ07_RS10650 ENOG4105C0A alcohol dehydrogenase GNZ07_RS10655 ENOG4105KNY Microcompartments protein GNZ07_RS10660 ENOG4105KNY Microcompartments protein GNZ07_RS10675 ENOG4107TXC Transcriptional regulator GNZ07_RS10690 ENOG4105DJ2 Major Facilitator Superfamily GNZ07_RS10695 ENOG41073TP transcriptional regulator GNZ07_RS10710 ENOG4108XI2 Domain of unknown function (DUF1963) GNZ07_RS10740 ENOG4105CJZ response regulator GNZ07_RS10755 ENOG4108IUW ABC transporter GNZ07_RS10770 ENOG4105VMP Transcriptional regulator GNZ07_RS10780 ENOG4105CPQ Dehydrogenase GNZ07_RS10800 ENOG4105C19 ABC transporter GNZ07_RS10825 ENOG4106ETB IIa component GNZ07_RS10830 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GNZ07_RS10845 ENOG4108UW5 maltose o-acetyltransferase GNZ07_RS10855 ENOG4105DUX Transporter GNZ07_RS10860 ENOG4108D32 Methyltransferase GNZ07_RS10865 ENOG41086D8 Transcriptional regulator GNZ07_RS10900 ENOG4105W1Y Transcriptional regulator GNZ07_RS10910 ENOG4108IMY Transcriptional regulator GNZ07_RS10925 ENOG4107R7I amino acid GNZ07_RS10935 ENOG4105CIZ coA-substrate-specific enzyme activase GNZ07_RS10945 ENOG4105C10 Electron transfer flavoprotein GNZ07_RS10950 ENOG4105BZJ Electron transfer flavoprotein GNZ07_RS10955 ENOG4105C1G acyl-Coa dehydrogenase GNZ07_RS10960 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GNZ07_RS10965 ENOG4105CMH dehydratase GNZ07_RS10990 ENOG4105FKZ Methyl-accepting chemotaxis GNZ07_RS11000 ENOG4107QHE Choloylglycine hydrolase GNZ07_RS11010 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GNZ07_RS11015 ENOG4105C6Z Gluconate GNZ07_RS11025 ENOG4105G63 Type III effector Hrp-dependent GNZ07_RS11030 ENOG4105E98 transcriptional regulator DeoR family GNZ07_RS11050 ENOG4108IG5 Transcriptional regulator GNZ07_RS11065 ENOG41090FM Phosphatase GNZ07_RS11075 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit GNZ07_RS11085 ENOG4107RSS Hydrogenase accessory protein HypB GNZ07_RS11100 ENOG4105D1F ATP-binding protein GNZ07_RS11115 ENOG4105ER2 Ompa motb domain protein GNZ07_RS11120 ENOG4105E14 MotA TolQ exbB proton channel GNZ07_RS11125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNZ07_RS11140 ENOG4105EPD Oligopeptide transporter, Opt family GNZ07_RS11145 ENOG4105CIN aminoacyl-histidine dipeptidase GNZ07_RS11155 ENOG4105BZW Glycerate kinase GNZ07_RS11160 ENOG4105E1F short-chain dehydrogenase reductase GNZ07_RS11165 ENOG4108SDH ABC, transporter GNZ07_RS11170 ENOG4108IUW ABC transporter GNZ07_RS11175 ENOG4107YB6 acetyltransferase, (GNAT) family GNZ07_RS11180 ENOG4108U05 Transcriptional regulator GNZ07_RS11205 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GNZ07_RS11215 ENOG4105E5D amino acid GNZ07_RS11220 ENOG4108UVJ appr-1-p processing domain protein GNZ07_RS11275 ENOG4105VKD bioY protein GNZ07_RS11285 ENOG4105DC7 peptidase M24 GNZ07_RS11290 ENOG4105DUX Transporter GNZ07_RS11370 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GNZ07_RS11375 ENOG4105BZ1 (ABC) transporter GNZ07_RS11380 ENOG4105BZ1 (ABC) transporter GNZ07_RS11410 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNZ07_RS11430 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GNZ07_RS11450 ENOG4105EKQ RNA-directed DNA polymerase GNZ07_RS11510 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GNZ07_RS11535 ENOG41062D9 Histidine kinase GNZ07_RS11540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS11565 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GNZ07_RS11575 ENOG4105WG9 Conserved Protein GNZ07_RS11585 ENOG4105CHM Aminotransferase GNZ07_RS11590 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GNZ07_RS11600 ENOG4106YN8 Prenyltransferase GNZ07_RS11605 ENOG4105MCT stage V sporulation protein S GNZ07_RS11615 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GNZ07_RS11620 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GNZ07_RS11630 ENOG4105CNU cell division protein FtsK GNZ07_RS11635 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GNZ07_RS11650 ENOG4105C1V Peptidase, M16 GNZ07_RS11665 ENOG4105DTN riboflavin biosynthesis protein ribF GNZ07_RS11675 ENOG4105SFS phosphoesterase RecJ domain protein GNZ07_RS11690 ENOG4105VHM ribosomal protein GNZ07_RS11695 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GNZ07_RS11700 ENOG4105CHV Transcription elongation factor NusA GNZ07_RS11710 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GNZ07_RS11715 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GNZ07_RS11720 ENOG4105DZP Membrane-associated zinc metalloprotease GNZ07_RS11740 ENOG4105KNE Phosphatidate cytidylyltransferase GNZ07_RS11745 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GNZ07_RS11775 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GNZ07_RS11780 ENOG4105C79 DNA protecting protein DprA GNZ07_RS11785 ENOG4105C0P Mg chelatase subunit ChlI GNZ07_RS11800 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GNZ07_RS11825 ENOG4105VB6 UPF0109 protein GNZ07_RS11845 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GNZ07_RS11865 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GNZ07_RS11870 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GNZ07_RS11880 ENOG41067VY 50S ribosomal protein L32 GNZ07_RS11885 ENOG4105KNH Nucleic acid-binding protein GNZ07_RS11895 ENOG4108IJ2 phosphate acetyltransferase GNZ07_RS11915 ENOG41088D5 d-proline reductase GNZ07_RS11935 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS11955 ENOG4105E5D amino acid GNZ07_RS11965 ENOG4105CTU Proline racemase GNZ07_RS11975 ENOG41088D5 d-proline reductase GNZ07_RS11990 ENOG41088D5 d-proline reductase GNZ07_RS12000 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GNZ07_RS12005 ENOG41088D5 d-proline reductase GNZ07_RS12010 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GNZ07_RS12025 ENOG41088D5 d-proline reductase GNZ07_RS12030 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GNZ07_RS12035 ENOG4108JUB Transcriptional regulator GNZ07_RS12060 ENOG4106H78 methyltransferase GNZ07_RS12065 ENOG4105CB5 ATP-dependent DNA helicase recG GNZ07_RS12070 ENOG4105DP4 dak2 domain fusion protein ylov GNZ07_RS12075 ENOG4108ZAA Alkaline-shock protein GNZ07_RS12100 ENOG4105DJV ribulose-phosphate 3-epimerase GNZ07_RS12110 ENOG4105D9P serine threonine protein kinase GNZ07_RS12115 ENOG4108ZF3 Phosphatase GNZ07_RS12125 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GNZ07_RS12135 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GNZ07_RS12140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GNZ07_RS12145 ENOG4105C25 Primosomal protein n' GNZ07_RS12150 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GNZ07_RS12160 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GNZ07_RS12170 ENOG4105DSJ YicC domain protein GNZ07_RS12175 ENOG4105HDK L-asparaginase GNZ07_RS12180 ENOG4105VMP Transcriptional regulator GNZ07_RS12195 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GNZ07_RS12210 ENOG4108UTW Plays a role in the regulation of phosphate uptake GNZ07_RS12215 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GNZ07_RS12220 ENOG4105E2Z phosphate ABC transporter (Permease GNZ07_RS12225 ENOG4105C8U phosphate abc transporter GNZ07_RS12230 ENOG4105CVA phosphate GNZ07_RS12235 ENOG4105BZU Histidine kinase GNZ07_RS12240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS12245 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GNZ07_RS12255 ENOG4108BIK prc-barrel domain-containing protein GNZ07_RS12260 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNZ07_RS12265 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNZ07_RS12270 ENOG4105FFI sigma-e processing peptidase spoiiga GNZ07_RS12275 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GNZ07_RS12280 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GNZ07_RS12295 ENOG4105CZX twitching motility protein GNZ07_RS12305 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNZ07_RS12330 ENOG4105T2N Domain of unknown function (DUF2382) GNZ07_RS12375 ENOG4105CJN penicillin-binding protein GNZ07_RS12385 ENOG4105CFP Peptidase U32 GNZ07_RS12395 ENOG4105HHA aminodeoxychorismate lyase GNZ07_RS12400 ENOG4105CI3 gtp-binding protein typa GNZ07_RS12405 ENOG4105CN5 Metallo-Beta-Lactamase GNZ07_RS12410 ENOG4105I3K Ferric uptake regulator, Fur family GNZ07_RS12435 ENOG4105C02 permease GNZ07_RS12445 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) GNZ07_RS12460 ENOG4105D1H recombination factor protein RarA GNZ07_RS12465 ENOG4107RVV histidinol phosphate phosphatase, hisj family GNZ07_RS12490 ENOG4105BZG amino acid carrier protein GNZ07_RS12495 ENOG4105BZG amino acid carrier protein GNZ07_RS12510 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GNZ07_RS12520 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GNZ07_RS12535 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GNZ07_RS12590 ENOG4105DWK Membrane GNZ07_RS12600 ENOG4105VPX protein, conserved in bacteria GNZ07_RS12615 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GNZ07_RS12620 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GNZ07_RS12630 ENOG4105DB7 PHP domain protein GNZ07_RS12635 ENOG4105DFM M18 family aminopeptidase GNZ07_RS12640 ENOG4105D7N magnesium and cobalt transport protein CorA GNZ07_RS12645 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GNZ07_RS12650 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GNZ07_RS12660 ENOG4108N5C SNARE associated Golgi protein-related protein GNZ07_RS12665 ENOG4108N5C SNARE associated Golgi protein-related protein GNZ07_RS12685 ENOG4105CKK Glycosyl transferase, family 2 GNZ07_RS12690 ENOG4105KHC sulfurtransferase GNZ07_RS12695 ENOG4105CBT Fructose-1,6-bisphosphatase GNZ07_RS12710 ENOG4105CNW domain protein GNZ07_RS12810 ENOG4105CGA flagellar basal-body rod protein FlgG GNZ07_RS12815 ENOG4105CGA flagellar basal-body rod protein FlgG GNZ07_RS12825 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNZ07_RS12840 ENOG4105FZW flagellar biosynthesis regulator FlhF GNZ07_RS12845 ENOG4105D7B Flagellar biosynthesis protein flha GNZ07_RS12850 ENOG4105D00 flagellar biosynthetic protein flhB GNZ07_RS12860 ENOG4105CN7 Flagellar biosynthetic protein FliP GNZ07_RS12875 ENOG4106VK6 Flagellar motor protein GNZ07_RS12880 ENOG4107R0U MotA TolQ exbB proton channel GNZ07_RS12885 ENOG41068WV flagellar FlbD family protein GNZ07_RS12890 ENOG4108JQA flagellar GNZ07_RS12900 ENOG410822I Flagellar hook capping protein GNZ07_RS12925 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GNZ07_RS12930 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GNZ07_RS12935 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GNZ07_RS12940 ENOG4108ZC9 flagellar basal-body rod protein flgc GNZ07_RS12945 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GNZ07_RS12950 ENOG4105I03 Flagellin GNZ07_RS12980 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GNZ07_RS12985 ENOG4108V3A UPF0421 protein GNZ07_RS13010 ENOG4105D2T synthase GNZ07_RS13015 ENOG4105F0R Cytidylyltransferase GNZ07_RS13025 ENOG41066S7 Glycosyltransferase family 52 GNZ07_RS13035 ENOG4105D5D udp-galactopyranose mutase GNZ07_RS13040 ENOG4105D3Q Sugar transferase GNZ07_RS13045 ENOG4107YJ4 chain length determinant protein GNZ07_RS13050 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GNZ07_RS13055 ENOG4105HTX biosynthesis protein GNZ07_RS13080 ENOG4105FKZ Methyl-accepting chemotaxis GNZ07_RS13085 ENOG4105I03 Flagellin GNZ07_RS13115 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GNZ07_RS13120 ENOG4108IAJ Nad-dependent epimerase dehydratase GNZ07_RS13125 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family GNZ07_RS13140 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GNZ07_RS13145 ENOG4105D2T synthase GNZ07_RS13155 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase GNZ07_RS13160 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GNZ07_RS13170 ENOG41090QV Protein of unknown function DUF115 GNZ07_RS13175 ENOG4105I03 Flagellin GNZ07_RS13185 ENOG4107RT6 flagellar hook-associated GNZ07_RS13190 ENOG4105MQ3 flagellar protein FliS GNZ07_RS13220 ENOG4105E1Q flagellar hook-associated protein GNZ07_RS13235 ENOG4105DD5 Flagellar motor switch protein GNZ07_RS13240 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GNZ07_RS13245 ENOG4108V3W Chemotaxis protein, CheW GNZ07_RS13250 ENOG4107YTP response regulator receiver protein GNZ07_RS13260 ENOG4105CBS Chea signal transduction histidine kinase GNZ07_RS13265 ENOG4105BZU Histidine kinase GNZ07_RS13270 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GNZ07_RS13280 ENOG4108V3W Chemotaxis protein, CheW GNZ07_RS13290 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane GNZ07_RS13330 ENOG4105BZU Histidine kinase GNZ07_RS13335 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GNZ07_RS13365 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GNZ07_RS13370 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNZ07_RS13375 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNZ07_RS13385 ENOG4105CKD glutathione-regulated potassium-efflux system protein GNZ07_RS13410 ENOG4105CMR udp-glucose 4-epimerase GNZ07_RS13415 ENOG4108Z29 Flavodoxin GNZ07_RS13425 ENOG41075H3 AraC family transcriptional regulator GNZ07_RS13430 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GNZ07_RS13440 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GNZ07_RS13460 ENOG4105DVE abc transporter atp-binding protein GNZ07_RS13465 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GNZ07_RS13500 ENOG4105E1K spore germination protein GNZ07_RS13515 ENOG4105C1J atp-dependent rna helicase GNZ07_RS13530 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS13550 ENOG41069ER domain protein GNZ07_RS13555 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GNZ07_RS13565 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GNZ07_RS13570 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GNZ07_RS13585 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GNZ07_RS13590 ENOG4107SJI Dehydrogenase GNZ07_RS13595 ENOG4105BZ8 glutamate synthase GNZ07_RS13615 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GNZ07_RS13620 ENOG41081HM 2'-5' rna ligase GNZ07_RS13630 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS13635 ENOG4105CS2 ec 3.2.1.21 GNZ07_RS13645 ENOG4105I3K Ferric uptake regulator, Fur family GNZ07_RS13665 ENOG4105CE4 GlcNAc 6-P deacetylase GNZ07_RS13675 ENOG4105CID antiterminator GNZ07_RS13680 ENOG4105C5Y PTS System GNZ07_RS13690 ENOG4107R73 Mate efflux family protein GNZ07_RS13695 ENOG4105DIW FeS assembly protein SUFB GNZ07_RS13700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GNZ07_RS13710 ENOG4105I3K Ferric uptake regulator, Fur family GNZ07_RS13720 ENOG4105CNW domain protein GNZ07_RS13725 ENOG4105C1G acyl-Coa dehydrogenase GNZ07_RS13730 ENOG4105DQ6 Transposase GNZ07_RS13745 ENOG4105ETZ PTS System GNZ07_RS13750 ENOG4105F3R pts system mannose fructose sorbose family iid GNZ07_RS13760 ENOG4107QP7 CoA-transferase subunit A GNZ07_RS13775 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase GNZ07_RS13780 ENOG4108XHQ (2Fe-2S)-binding domain protein GNZ07_RS13790 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GNZ07_RS13795 ENOG4105CS2 ec 3.2.1.21 GNZ07_RS13800 ENOG4105CS2 ec 3.2.1.21 GNZ07_RS13805 ENOG4107RWR Sodium hydrogen exchanger GNZ07_RS13845 ENOG4105C5H ABC transporter GNZ07_RS13900 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GNZ07_RS13910 ENOG4105BZ1 (ABC) transporter GNZ07_RS13915 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GNZ07_RS13925 ENOG4105E0M Sulfatase GNZ07_RS13930 ENOG4105EJ9 Membrane GNZ07_RS13940 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GNZ07_RS13945 ENOG4108R6K riboflavin synthase, subunit alpha GNZ07_RS13950 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GNZ07_RS13955 ENOG4105CIN aminoacyl-histidine dipeptidase GNZ07_RS13960 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GNZ07_RS13965 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GNZ07_RS13975 ENOG4105C12 Phosphoribosylglycinamide synthetase GNZ07_RS13985 ENOG4108V3E phosphoribosylglycinamide formyltransferase GNZ07_RS14005 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GNZ07_RS14015 ENOG4107S4Y M20 DapE family protein YgeY GNZ07_RS14020 ENOG4107UUR Chlorohydrolase aminohydrolase GNZ07_RS14025 ENOG4105BZ8 glutamate synthase GNZ07_RS14030 ENOG4105IW6 Carbamoyltransferase GNZ07_RS14040 ENOG4105C2W permease GNZ07_RS14045 ENOG4107RCH Diaminopropionate ammonia-lyase GNZ07_RS14050 ENOG4108JUB Transcriptional regulator GNZ07_RS14055 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC GNZ07_RS14060 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GNZ07_RS14065 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GNZ07_RS14080 ENOG4105EHG Permease protein GNZ07_RS14085 ENOG4105E0A ABC, transporter GNZ07_RS14110 ENOG4105C7N Xanthine uracil vitamin C permease GNZ07_RS14115 ENOG4105BZG amino acid carrier protein GNZ07_RS14120 ENOG4105EEM helicase GNZ07_RS14140 ENOG4108ZGC gaf domain protein GNZ07_RS14145 ENOG4105C37 (CBS) domain GNZ07_RS14185 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GNZ07_RS14190 ENOG4105NBU tryptophan transport protein GNZ07_RS14200 ENOG4107V6Q Cyclic nucleotide-binding domain GNZ07_RS14225 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GNZ07_RS14255 ENOG4105EGD dinuclear metal center protein, YbgI family GNZ07_RS14270 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNZ07_RS14275 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GNZ07_RS14280 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GNZ07_RS14290 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GNZ07_RS14300 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GNZ07_RS14305 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GNZ07_RS14330 ENOG4105CTJ Metal Dependent Phosphohydrolase GNZ07_RS14345 ENOG4105KTH gatB Yqey GNZ07_RS14355 ENOG4107YU2 histidine triad (hIT) protein GNZ07_RS14360 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GNZ07_RS14365 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GNZ07_RS14375 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GNZ07_RS14385 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GNZ07_RS14390 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GNZ07_RS14395 ENOG4105CSA Coproporphyrinogen iii oxidase GNZ07_RS14415 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GNZ07_RS14455 ENOG4105EM7 Selenocysteine-specific translation elongation factor GNZ07_RS14475 ENOG4105DZ1 carboxypeptidase GNZ07_RS14480 ENOG4108YBP pseudouridine synthase GNZ07_RS14485 ENOG4105KME endoribonuclease L-psp GNZ07_RS14490 ENOG4108KGH TRANSCRIPTIONal GNZ07_RS14495 ENOG4108WF2 Metal Dependent Phosphohydrolase GNZ07_RS14505 ENOG410812S Rna-binding protein GNZ07_RS14530 ENOG4105C03 ribonuclease GNZ07_RS14550 ENOG4105DR5 peptidase GNZ07_RS14555 ENOG4105CNI cell division protein FtsW GNZ07_RS14565 ENOG4107QMS site-determining protein GNZ07_RS14570 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GNZ07_RS14575 ENOG4107RF6 penicillin-binding protein GNZ07_RS14590 ENOG4105DFF Rod shape-determining protein mreb GNZ07_RS14645 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GNZ07_RS14650 ENOG4105C2M dna polymerase I GNZ07_RS14655 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GNZ07_RS14835 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GNZ07_RS14875 ENOG4105D4P Coproporphyrinogen iii oxidase GNZ07_RS14880 ENOG4105C5X domain protein GNZ07_RS14890 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GNZ07_RS14905 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GNZ07_RS14910 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GNZ07_RS14930 ENOG4105VIE preprotein translocase, subunit YajC GNZ07_RS14965 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GNZ07_RS14990 ENOG4105VCQ rubredoxin GNZ07_RS14995 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GNZ07_RS15000 ENOG4108UGV hypoxanthine phosphoribosyltransferase GNZ07_RS15020 ENOG4105CZ3 stage V sporulation protein ad GNZ07_RS15025 ENOG41090VF Stage v sporulation protein ac GNZ07_RS15030 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNZ07_RS15035 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GNZ07_RS15040 ENOG41082AN stage II sporulation protein GNZ07_RS15065 ENOG4105D3Q Sugar transferase GNZ07_RS15075 ENOG4105CJR Integral membrane protein (MviN GNZ07_RS15085 ENOG4105CPK Glycosyl transferase (Group 1 GNZ07_RS15100 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GNZ07_RS15105 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GNZ07_RS15140 ENOG4107QQG Dehydrogenase GNZ07_RS15165 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GNZ07_RS15180 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GNZ07_RS15185 ENOG4105CXN decarboxylase GNZ07_RS15195 ENOG4107RE7 phosphate butyryltransferase GNZ07_RS15205 ENOG4105EWC Purine nucleoside phosphorylase GNZ07_RS15215 ENOG4105CFP Peptidase U32 GNZ07_RS15250 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GNZ07_RS15260 ENOG4108RWN rrna methyltransferase GNZ07_RS15265 ENOG4107ZYR domain protein GNZ07_RS15270 ENOG4105CZN Potassium uptake protein GNZ07_RS15285 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GNZ07_RS15310 ENOG4105DA5 (ABC) transporter GNZ07_RS15345 ENOG4108D32 Methyltransferase GNZ07_RS15355 ENOG4108JQ7 (ABC) transporter GNZ07_RS15365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNZ07_RS15370 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GNZ07_RS15375 ENOG4107QSI ABC, transporter GNZ07_RS15380 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GNZ07_RS15385 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GNZ07_RS15390 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GNZ07_RS15395 ENOG4105CHM Aminotransferase GNZ07_RS15440 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GNZ07_RS15445 ENOG41080E2 ribosomal-protein-alanine acetyltransferase GNZ07_RS15450 ENOG4105C19 ABC transporter GNZ07_RS15460 ENOG4105D2X ABC transporter substrate-binding protein GNZ07_RS15475 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GNZ07_RS15495 ENOG4108J6I peptidase, M16 GNZ07_RS15520 ENOG4105NBK UPF0345 protein GNZ07_RS15525 ENOG4105II7 pyrroline-5-carboxylate reductase GNZ07_RS15530 ENOG4105C6N Formate acetyltransferase GNZ07_RS15535 ENOG4105F1A Pyruvate formate-lyase GNZ07_RS15540 ENOG4105WBV Transcriptional regulator GNZ07_RS15560 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) GNZ07_RS15590 ENOG4105CIZ coA-substrate-specific enzyme activase GNZ07_RS15600 ENOG4105C10 Electron transfer flavoprotein GNZ07_RS15605 ENOG4105BZJ Electron transfer flavoprotein GNZ07_RS15610 ENOG4105C1G acyl-Coa dehydrogenase GNZ07_RS15615 ENOG4105CHU acetyl-coa acetyltransferase GNZ07_RS15620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GNZ07_RS15625 ENOG4105E39 Enoyl-CoA hydratase GNZ07_RS15640 ENOG4105C7N Xanthine uracil vitamin C permease GNZ07_RS15645 ENOG4105EQI Metal Dependent Phosphohydrolase GNZ07_RS15670 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GNZ07_RS15675 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS15680 ENOG4105KY8 Rubrerythrin GNZ07_RS15700 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GNZ07_RS15710 ENOG4105G5W regulator Fur family GNZ07_RS15725 ENOG4105D29 Helix-turn-helix type 11 domain protein GNZ07_RS15750 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GNZ07_RS15755 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GNZ07_RS15760 ENOG4108IUQ atp-dependent protease GNZ07_RS15780 ENOG4107TRN Xylose isomerase domain protein TIM barrel GNZ07_RS15795 ENOG4107W93 Dihydroorotate dehydrogenase GNZ07_RS15800 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GNZ07_RS15825 ENOG4105CIZ coA-substrate-specific enzyme activase GNZ07_RS15835 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GNZ07_RS15840 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GNZ07_RS15860 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GNZ07_RS16025 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GNZ07_RS16040 ENOG4105DEF Extracellular solute-binding protein, family 5 GNZ07_RS16075 ENOG4105C4R Atp-dependent dna helicase GNZ07_RS16080 ENOG4105KGF protein, YerC YecD GNZ07_RS16090 ENOG4105E4C Lytic transglycosylase catalytic GNZ07_RS16105 ENOG4107XJU UPF0178 protein GNZ07_RS16130 ENOG4105C5I Dehydrogenase GNZ07_RS16145 ENOG4105C10 Electron transfer flavoprotein GNZ07_RS16150 ENOG4105BZJ Electron transfer flavoprotein GNZ07_RS16155 ENOG4105C1G acyl-Coa dehydrogenase GNZ07_RS16180 ENOG4105CEY Amp-dependent synthetase and ligase GNZ07_RS16195 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GNZ07_RS16200 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GNZ07_RS16240 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein GNZ07_RS16250 ENOG4105C5H ABC transporter GNZ07_RS16255 ENOG4105DY9 regulatoR GNZ07_RS16260 ENOG4108HRK Histidine kinase GNZ07_RS16275 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GNZ07_RS16310 ENOG4105DSE periplasmic solute binding protein GNZ07_RS16315 ENOG4105DHT Metal Dependent Phosphohydrolase GNZ07_RS16320 ENOG4105K8N protein family UPF0079, ATPase GNZ07_RS16325 ENOG41072GX Peptidase M22 Glycoprotease GNZ07_RS16330 ENOG410801F ribosomal-protein-alanine acetyltransferase GNZ07_RS16365 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GNZ07_RS16370 ENOG410667J hydrolase GNZ07_RS16375 ENOG4105C31 Tryptophanyl-tRNA synthetase GNZ07_RS16380 ENOG4105MAX Superoxide reductase GNZ07_RS16435 ENOG4105CJ1 ABC, transporter GNZ07_RS16460 ENOG4105BZ1 (ABC) transporter GNZ07_RS16465 ENOG4105E2V Glycosyltransferase 36 GNZ07_RS16480 ENOG4105DFM M18 family aminopeptidase GNZ07_RS16495 ENOG4105EEM helicase GNZ07_RS16500 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GNZ07_RS16505 ENOG4107QSE Dipeptidase GNZ07_RS16515 ENOG4105VC4 domain protein GNZ07_RS16525 ENOG4105DA5 (ABC) transporter GNZ07_RS16535 ENOG4105JVQ RNA Polymerase GNZ07_RS16540 ENOG4105CHH sulfate transporter GNZ07_RS16560 ENOG4105CJ1 ABC, transporter GNZ07_RS16580 ENOG4105RD7 BadF BadG BcrA BcrD GNZ07_RS16585 ENOG4105VCP PTS System GNZ07_RS16595 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GNZ07_RS16600 ENOG4105CK1 PTS System GNZ07_RS16605 ENOG4105F8D glycoside hydrolase family 4 GNZ07_RS16615 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNZ07_RS16630 ENOG4105X5K response regulator receiver protein GNZ07_RS16635 ENOG4105KVH Transcriptional regulator GNZ07_RS16660 ENOG4105VUF Transcriptional regulator GNZ07_RS16665 ENOG4107ZT6 cytidine deaminase GNZ07_RS16675 ENOG4105UEI Transcriptional Regulator AraC Family GNZ07_RS16680 ENOG4105NAE bifunctional deaminase-reductase domain protein GNZ07_RS16695 ENOG41062ES Transcriptional regulator GNZ07_RS16700 ENOG4108Z1Z gCN5-related N-acetyltransferase GNZ07_RS16705 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GNZ07_RS16720 ENOG4105CA9 Pyruvate kinase GNZ07_RS16730 ENOG4105C0B DNA polymerase III (alpha subunit) GNZ07_RS16740 ENOG4105CHW UPF0052 protein GNZ07_RS16765 ENOG4107K5X Membrane-bound metal-dependent hydrolase GNZ07_RS16775 ENOG4105CJN penicillin-binding protein GNZ07_RS16785 ENOG4105TV9 FHA Domain-Containing protein GNZ07_RS16790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GNZ07_RS16800 ENOG4105DZP Membrane-associated zinc metalloprotease GNZ07_RS16810 ENOG4105CRP Part of the ABC transporter FtsEX involved in GNZ07_RS16815 ENOG4105CAK Cell division ATP-binding protein ftsE GNZ07_RS16820 ENOG4108JYZ YitT family GNZ07_RS16835 ENOG4108HHA Transketolase GNZ07_RS16850 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GNZ07_RS16860 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GNZ07_RS16865 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GNZ07_RS16880 ENOG4107U9T Pfam:Ribonuclease_BN GNZ07_RS16905 ENOG4108Z6Z Transcriptional regulator GNZ07_RS16915 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GNZ07_RS16920 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GNZ07_RS16925 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GNZ07_RS16930 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GNZ07_RS16935 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GNZ07_RS16940 ENOG4105VI0 Pts system, glucitol sorbitol-specific GNZ07_RS16945 ENOG4105DZY Pts system, glucitol sorbitol-specific GNZ07_RS16950 ENOG410787A Pts system, glucitol sorbitol-specific GNZ07_RS16960 ENOG4107WTH Galactitol-1-phosphate dehydrogenase GNZ07_RS16965 ENOG4105DKT Transcriptional regulator GNZ07_RS16985 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GNZ07_RS17000 ENOG4105CKM Branched-chain carboxylic acid kinase GNZ07_RS17005 ENOG4107RE7 phosphate butyryltransferase GNZ07_RS17010 ENOG4105CKM Branched-chain carboxylic acid kinase GNZ07_RS17015 ENOG4105DZ0 fad dependent oxidoreductase GNZ07_RS17025 ENOG4105C8B TIGR00159 family GNZ07_RS17030 ENOG4105F0V Cell wall hydrolase GNZ07_RS17035 ENOG4105C3M thioredoxin reductase GNZ07_RS17040 ENOG4105K63 Thioredoxin GNZ07_RS17045 ENOG4105DYB Isoaspartyl dipeptidase GNZ07_RS17060 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GNZ07_RS17065 ENOG4108JUB Transcriptional regulator GNZ07_RS17080 ENOG4107GFK fumarate GNZ07_RS17085 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNZ07_RS17105 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GNZ07_RS17110 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GNZ07_RS17115 ENOG4108JJB ABC transporter GNZ07_RS17120 ENOG4108JJB ABC transporter GNZ07_RS17150 ENOG41067V7 50S ribosomal protein L36 GNZ07_RS17175 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GNZ07_RS17250 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GNZ07_RS17305 ENOG4105XPM ribosomal protein GNZ07_RS17325 ENOG4108VZM 50s ribosomal protein L10 GNZ07_RS17340 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GNZ07_RS17370 ENOG4105QIV RNA polymerase GNZ07_RS17380 ENOG4105C2N RNA methyltransferase TrmH family group 3 GNZ07_RS17385 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) GNZ07_RS17390 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) GNZ07_RS17400 ENOG4105C7B Threonine dehydratase GNZ07_RS17405 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GNZ07_RS17415 ENOG4105CTP PilT protein domain protein GNZ07_RS17430 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GNZ07_RS17440 ENOG41066A3 ATP guanido phosphotransferase GNZ07_RS17445 ENOG4108Z0C Uvrb UvrC protein GNZ07_RS17460 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GNZ07_RS17520 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GNZ07_RS17540 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GNZ07_RS17555 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GNZ07_RS17560 ENOG4108UGV hypoxanthine phosphoribosyltransferase GNZ07_RS17565 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GNZ07_RS17610 ENOG41060GV RNA binding s1 domain protein GNZ07_RS17630 ENOG41082I2 s4 domain protein GNZ07_RS17640 ENOG4108IY2 MazG family GNZ07_RS17645 ENOG4105CKP Polysaccharide Biosynthesis Protein GNZ07_RS17650 ENOG4108M14 stage v sporulation protein t GNZ07_RS17660 ENOG4108JA2 transcriptioN-repair coupling factor GNZ07_RS17670 ENOG4105C0H protease GNZ07_RS17675 ENOG4105BZU Histidine kinase GNZ07_RS17680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNZ07_RS17685 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GNZ07_RS17700 ENOG4105DFT pur operon repressor GNZ07_RS17725 ENOG4107VXZ Hydrolase GNZ07_RS17740 ENOG4105N5T Radical SAM Protein GNZ07_RS17750 ENOG4108K88 Membrane GNZ07_RS17760 ENOG4105C8Q Methyl-accepting chemotaxis GNZ07_RS17775 ENOG4107ZE5 PPIases accelerate the folding of proteins GNZ07_RS17785 ENOG4105CFQ glutamine synthetase GNZ07_RS17800 ENOG4105Q2H domain protein GNZ07_RS17810 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GNZ07_RS17825 ENOG4105EQ0 Major Facilitator superfamily GNZ07_RS17835 ENOG4108JGH Tetr family transcriptional regulator GNZ07_RS17840 ENOG4105HFT AraC family transcriptional regulator GNZ07_RS17845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GNZ07_RS17850 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase GNZ07_RS17855 ENOG4105G0K glycine radical enzyme YjjI family GNZ07_RS17860 ENOG41076CZ activating enzyme GNZ07_RS17870 ENOG4107QW8 radical SAM domain protein GNZ07_RS17880 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GNZ07_RS17890 ENOG4105CG5 Glycosyl transferase (Group 1 GNZ07_RS17895 ENOG4105DB7 PHP domain protein GNZ07_RS17910 ENOG4105DUM transcriptional regulator, lysR family GNZ07_RS17915 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin GNZ07_RS17930 ENOG4108FRU Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GNZ07_RS17940 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GNZ07_RS17955 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GNZ07_RS17960 ENOG4105CHR reductase GNZ07_RS17965 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GNZ07_RS17970 ENOG4105EA8 2-Nitropropane dioxygenase GNZ07_RS17995 ENOG4105DR5 peptidase GNZ07_RS18075 ENOG4105CBX hi0933 family GNZ07_RS18110 ENOG4105CDU Replicative dna helicase GNZ07_RS18115 ENOG4108IUQ atp-dependent protease GNZ07_RS18125 ENOG4105BZR domain protein GNZ07_RS18145 ENOG4108UUM single-stranded DNA-binding protein GNZ07_RS18155 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GNZ07_RS18165 ENOG4105D8X mechanosensitive ion channel GNZ07_RS18175 ENOG4105C9B Cysteine desulfurase GNZ07_RS18180 ENOG4108REF Sporulation integral membrane protein ytvi GNZ07_RS18185 ENOG4108ZDA Sporulation protein YyaC GNZ07_RS18200 ENOG4105FA0 parb-like partition protein GNZ07_RS18205 ENOG4107QJE Chromosome Partitioning Protein GNZ07_RS18210 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) GNZ07_RS18235 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins