locus-tag	class	description
DRB99_RS00015	COG0730	response to heat
DRB99_RS00020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DRB99_RS00025	COG0659	secondary active sulfate transmembrane transporter activity
DRB99_RS00035	COG0004	ammonium transporteR
DRB99_RS00040	COG0347	Belongs to the P(II) protein family
DRB99_RS00045	COG1115	amino acid carrier protein
DRB99_RS00050	COG0617	tRNA 3'-terminal CCA addition
DRB99_RS00055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DRB99_RS00060	COG1360	Flagellar Motor Protein
DRB99_RS00070	COG0513	Belongs to the DEAD box helicase family
DRB99_RS00080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DRB99_RS00085	COG3590	peptidase
DRB99_RS00100	COG0582	viral genome integration into host DNA
DRB99_RS00155	COG2207	Transcriptional regulator
DRB99_RS00160	COG3250	beta-galactosidase activity
DRB99_RS00165	COG2211	Major facilitator Superfamily
DRB99_RS00230	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DRB99_RS00240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DRB99_RS00245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS00250	COG3715	PTS system
DRB99_RS00255	COG3716	PTS system mannose fructose sorbose family IID component
DRB99_RS00280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DRB99_RS00290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DRB99_RS00305	COG1492	cobalamin metabolic process
DRB99_RS00310	COG3620	sequence-specific DNA binding
DRB99_RS00325	COG1609	Transcriptional regulator
DRB99_RS00330	COG1621	beta-fructofuranosidase activity
DRB99_RS00335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DRB99_RS00370	COG0860	N-Acetylmuramoyl-L-alanine amidase
DRB99_RS00380	COG4536	flavin adenine dinucleotide binding
DRB99_RS00385	COG0590	tRNA wobble adenosine to inosine editing
DRB99_RS00395	COG5566	PFAM Mor transcription activator
DRB99_RS00405	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DRB99_RS00420	COG1595	DNA-templated transcription, initiation
DRB99_RS00430	COG3328	transposase activity
DRB99_RS00465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DRB99_RS00470	COG1454	alcohol dehydrogenase
DRB99_RS00480	COG0252	asparaginase activity
DRB99_RS00485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DRB99_RS00490	COG0765	amino acid transport
DRB99_RS00495	COG1126	abc transporter atp-binding protein
DRB99_RS00500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DRB99_RS00510	COG0179	Fumarylacetoacetate (FAA) hydrolase
DRB99_RS00515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DRB99_RS00520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DRB99_RS00530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DRB99_RS00565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DRB99_RS00570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DRB99_RS00585	COG0601	transmembrane transport
DRB99_RS00590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DRB99_RS00595	COG0444	Belongs to the ABC transporter superfamily
DRB99_RS00600	COG4608	Belongs to the ABC transporter superfamily
DRB99_RS00610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DRB99_RS00615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DRB99_RS00620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DRB99_RS00625	COG3711	transcriptional antiterminator
DRB99_RS00630	COG1263	PTS System
DRB99_RS00630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS00630	COG2190	(PTS) system
DRB99_RS00635	COG2190	(PTS) system
DRB99_RS00660	COG0297	glycogen (starch) synthase activity
DRB99_RS00675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DRB99_RS00680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DRB99_RS00720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DRB99_RS00775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DRB99_RS00795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DRB99_RS00810	COG1476	TRANSCRIPTIONal
DRB99_RS00830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DRB99_RS00835	COG2378	regulation of single-species biofilm formation
DRB99_RS00865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DRB99_RS00870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DRB99_RS00875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DRB99_RS00890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DRB99_RS00895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DRB99_RS00900	COG2002	toxin-antitoxin pair type II binding
DRB99_RS00910	COG1199	ATP-dependent helicase activity
DRB99_RS00935	COG1696	Membrane protein involved in D-alanine export
DRB99_RS00940	COG1295	ribonuclease BN
DRB99_RS00955	COG0736	holo-[acyl-carrier-protein] synthase activity
DRB99_RS00960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DRB99_RS00960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DRB99_RS00975	COG2337	Toxic component of a toxin-antitoxin (TA) module
DRB99_RS00980	COG3959	Transketolase, thiamine diphosphate binding domain
DRB99_RS00985	COG3958	Transketolase
DRB99_RS00990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DRB99_RS00995	COG2884	Cell division ATP-binding protein ftsE
DRB99_RS01000	COG2177	Part of the ABC transporter FtsEX involved in
DRB99_RS01005	COG0793	Belongs to the peptidase S41A family
DRB99_RS01005	COG3409	Peptidoglycan-binding domain 1 protein
DRB99_RS01015	COG0556	nucleotide-excision repair
DRB99_RS01035	COG0768	penicillin binding
DRB99_RS01040	COG0322	excinuclease ABC activity
DRB99_RS01045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DRB99_RS01050	COG1660	Displays ATPase and GTPase activities
DRB99_RS01055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DRB99_RS01060	COG1481	regulation of sporulation
DRB99_RS01110	COG0469	pyruvate kinase activity
DRB99_RS01135	COG1404	Belongs to the peptidase S8 family
DRB99_RS01145	COG3385	transposase activity
DRB99_RS01165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DRB99_RS01170	COG0569	domain protein
DRB99_RS01175	COG2205	protein histidine kinase activity
DRB99_RS01180	COG0745	RESPONSE REGULATOR receiver
DRB99_RS01190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DRB99_RS01195	COG4988	ABC transporter
DRB99_RS01200	COG1132	(ABC) transporter
DRB99_RS01210	COG2832	Protein of unknown function (DUF454)
DRB99_RS01225	COG0789	Transcriptional regulator
DRB99_RS01225	COG4978	Transcriptional regulator
DRB99_RS01230	COG1811	Na channel or pump
DRB99_RS01245	COG1473	amidohydrolase
DRB99_RS01260	COG3279	Response regulator of the LytR AlgR family
DRB99_RS01270	COG1937	Protein conserved in bacteria
DRB99_RS01275	COG2217	Heavy metal translocating P-type atpase
DRB99_RS01280	COG2608	mercury ion transmembrane transporter activity
DRB99_RS01285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DRB99_RS01295	COG0840	transmembrane signaling receptor activity
DRB99_RS01315	COG0019	diaminopimelate decarboxylase activity
DRB99_RS01340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DRB99_RS01345	COG3973	AAA domain
DRB99_RS01350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DRB99_RS01355	COG0765	amino acid transport
DRB99_RS01360	COG1126	abc transporter atp-binding protein
DRB99_RS01365	COG3590	peptidase
DRB99_RS01370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DRB99_RS01375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DRB99_RS01380	COG1418	mRNA catabolic process
DRB99_RS01385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DRB99_RS01390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DRB99_RS01390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DRB99_RS01400	COG1362	aminopeptidase activity
DRB99_RS01410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DRB99_RS01415	COG3459	Glycosyltransferase 36 associated
DRB99_RS01420	COG4974	Belongs to the 'phage' integrase family
DRB99_RS01425	COG2202	Pas domain
DRB99_RS01425	COG2199	diguanylate cyclase activity
DRB99_RS01425	COG2200	EAL domain
DRB99_RS01430	COG5002	protein histidine kinase activity
DRB99_RS01435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DRB99_RS01515	COG0438	transferase activity, transferring glycosyl groups
DRB99_RS01520	COG1216	Glycosyl transferase, family 2
DRB99_RS01530	COG1682	transport, permease protein
DRB99_RS01545	COG1216	Glycosyl transferase, family 2
DRB99_RS01555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DRB99_RS01555	COG0546	phosphoglycolate phosphatase activity
DRB99_RS01580	COG0745	RESPONSE REGULATOR receiver
DRB99_RS01585	COG2205	protein histidine kinase activity
DRB99_RS01635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DRB99_RS01640	COG3944	biosynthesis protein
DRB99_RS01645	COG0489	protein tyrosine kinase activity
DRB99_RS01655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DRB99_RS01660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DRB99_RS01680	COG5039	Polysaccharide pyruvyl transferase
DRB99_RS01685	COG0438	transferase activity, transferring glycosyl groups
DRB99_RS01690	COG0438	transferase activity, transferring glycosyl groups
DRB99_RS01695	COG0463	Glycosyl transferase, family 2
DRB99_RS01695	COG1216	Glycosyl transferase, family 2
DRB99_RS01705	COG0562	UDP-galactopyranose mutase
DRB99_RS01710	COG2244	polysaccharide biosynthetic process
DRB99_RS01715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DRB99_RS01720	COG0840	transmembrane signaling receptor activity
DRB99_RS01730	COG1136	(ABC) transporter
DRB99_RS01730	COG0577	efflux transmembrane transporter activity
DRB99_RS01800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DRB99_RS01805	COG0860	N-Acetylmuramoyl-L-alanine amidase
DRB99_RS01805	COG2247	cell wall binding repeat
DRB99_RS01810	COG0860	N-Acetylmuramoyl-L-alanine amidase
DRB99_RS01835	COG4750	Nucleotidyl transferase
DRB99_RS01865	COG0366	Alpha amylase catalytic
DRB99_RS01885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DRB99_RS01890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DRB99_RS01895	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DRB99_RS01900	COG0697	spore germination
DRB99_RS01905	COG1486	melibiose metabolic process
DRB99_RS01910	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS01915	COG0561	phosphatase activity
DRB99_RS01920	COG0840	transmembrane signaling receptor activity
DRB99_RS01930	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS01940	COG0004	ammonium transporteR
DRB99_RS01945	COG0347	Belongs to the P(II) protein family
DRB99_RS01955	COG2188	Transcriptional regulator
DRB99_RS01965	COG1174	glycine betaine transport
DRB99_RS01970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DRB99_RS01985	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS02000	COG0395	ABC-type sugar transport system, permease component
DRB99_RS02015	COG1609	Transcriptional regulator
DRB99_RS02025	COG0840	transmembrane signaling receptor activity
DRB99_RS02045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS02050	COG1447	Phosphotransferase system cellobiose-specific component IIA
DRB99_RS02060	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS02065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DRB99_RS02070	COG1486	melibiose metabolic process
DRB99_RS02085	COG1737	Transcriptional regulator
DRB99_RS02090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DRB99_RS02090	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DRB99_RS02095	COG1447	Phosphotransferase system cellobiose-specific component IIA
DRB99_RS02110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS02120	COG1175	transmembrane transport
DRB99_RS02125	COG0395	ABC-type sugar transport system, permease component
DRB99_RS02130	COG1349	DNA-binding transcription factor activity
DRB99_RS02170	COG1017	nitric oxide dioxygenase activity
DRB99_RS02170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DRB99_RS02180	COG1595	DNA-templated transcription, initiation
DRB99_RS02185	COG2199	diguanylate cyclase activity
DRB99_RS02185	COG2203	Gaf domain
DRB99_RS02200	COG1442	glycosyl transferase family 8
DRB99_RS02200	COG1216	Glycosyl transferase, family 2
DRB99_RS02205	COG3475	LICD family
DRB99_RS02210	COG1216	Glycosyl transferase, family 2
DRB99_RS02210	COG1442	glycosyl transferase family 8
DRB99_RS02230	COG0840	transmembrane signaling receptor activity
DRB99_RS02240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DRB99_RS02250	COG1114	Component of the transport system for branched-chain amino acids
DRB99_RS02255	COG1592	Rubrerythrin
DRB99_RS02255	COG1773	rubredoxin
DRB99_RS02260	COG1131	(ABC) transporter
DRB99_RS02265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DRB99_RS02270	COG1136	(ABC) transporter
DRB99_RS02270	COG0577	efflux transmembrane transporter activity
DRB99_RS02280	COG0745	RESPONSE REGULATOR receiver
DRB99_RS02285	COG5002	protein histidine kinase activity
DRB99_RS02290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DRB99_RS02295	COG0438	transferase activity, transferring glycosyl groups
DRB99_RS02300	COG2199	diguanylate cyclase activity
DRB99_RS02300	COG2203	Gaf domain
DRB99_RS02310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DRB99_RS02330	COG0840	transmembrane signaling receptor activity
DRB99_RS02330	COG3290	protein histidine kinase activity
DRB99_RS02340	COG2357	RelA SpoT domain protein
DRB99_RS02375	COG0717	Belongs to the dCTP deaminase family
DRB99_RS02380	COG1131	(ABC) transporter
DRB99_RS02395	COG0495	leucyl-tRNA aminoacylation
DRB99_RS02415	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DRB99_RS02420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DRB99_RS02425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DRB99_RS02430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DRB99_RS02435	COG1605	Chorismate mutase
DRB99_RS02435	COG0077	Prephenate dehydratase
DRB99_RS02440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DRB99_RS02450	COG0583	DNA-binding transcription factor activity
DRB99_RS02460	COG0662	Cupin 2, conserved barrel domain protein
DRB99_RS02460	COG2207	Transcriptional regulator
DRB99_RS02465	COG2271	Major facilitator Superfamily
DRB99_RS02470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DRB99_RS02485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DRB99_RS02495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DRB99_RS02505	COG1737	Transcriptional regulator
DRB99_RS02515	COG0601	transmembrane transport
DRB99_RS02520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DRB99_RS02525	COG0444	Belongs to the ABC transporter superfamily
DRB99_RS02530	COG4608	Belongs to the ABC transporter superfamily
DRB99_RS02535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DRB99_RS02540	COG1053	succinate dehydrogenase
DRB99_RS02545	COG3458	cephalosporin-C deacetylase activity
DRB99_RS02555	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DRB99_RS02560	COG1940	carbohydrate kinase activity
DRB99_RS02585	COG2972	Histidine kinase
DRB99_RS02590	COG4753	response regulator
DRB99_RS02590	COG2207	Transcriptional regulator
DRB99_RS02600	COG3842	ATPase activity
DRB99_RS02620	COG0395	ABC-type sugar transport system, permease component
DRB99_RS02625	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
DRB99_RS02630	COG0840	transmembrane signaling receptor activity
DRB99_RS02650	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DRB99_RS02650	COG2755	lipolytic protein G-D-S-L family
DRB99_RS02655	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS02660	COG1482	cell wall glycoprotein biosynthetic process
DRB99_RS02665	COG2188	Transcriptional regulator
DRB99_RS02670	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DRB99_RS02680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DRB99_RS02695	COG1215	transferase activity, transferring glycosyl groups
DRB99_RS02710	COG1268	BioY protein
DRB99_RS02715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DRB99_RS02720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DRB99_RS02725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DRB99_RS02730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DRB99_RS02735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DRB99_RS02740	COG0165	Argininosuccinate lyase
DRB99_RS02745	COG0137	argininosuccinate synthase activity
DRB99_RS02755	COG2323	membrane
DRB99_RS02760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DRB99_RS02765	COG3711	transcriptional antiterminator
DRB99_RS02770	COG1263	PTS System
DRB99_RS02770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS02780	COG1760	l-serine dehydratase
DRB99_RS02790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DRB99_RS02795	COG0569	domain protein
DRB99_RS02810	COG1902	pentaerythritol trinitrate reductase activity
DRB99_RS02815	COG1959	2 iron, 2 sulfur cluster binding
DRB99_RS02825	COG0488	(ABC) transporter
DRB99_RS02840	COG1378	Sugar-specific transcriptional regulator TrmB
DRB99_RS02845	COG2814	Major facilitator Superfamily
DRB99_RS02850	COG3708	Transcriptional regulator
DRB99_RS02850	COG2207	Transcriptional regulator
DRB99_RS02865	COG0351	phosphomethylpyrimidine kinase
DRB99_RS02875	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DRB99_RS02880	COG0352	thiamine-phosphate diphosphorylase activity
DRB99_RS02890	COG0514	ATP-dependent DNA helicase (RecQ)
DRB99_RS02895	COG0613	PHP domain protein
DRB99_RS02910	COG0561	phosphatase activity
DRB99_RS02920	COG1307	EDD domain protein, DegV family
DRB99_RS02925	COG0366	Alpha amylase catalytic
DRB99_RS02950	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DRB99_RS02955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DRB99_RS02960	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DRB99_RS02965	COG0366	Alpha amylase catalytic
DRB99_RS02975	COG2207	Transcriptional regulator
DRB99_RS02990	COG1175	transmembrane transport
DRB99_RS02995	COG0395	ABC-type sugar transport system, permease component
DRB99_RS03000	COG0840	transmembrane signaling receptor activity
DRB99_RS03020	COG1940	carbohydrate kinase activity
DRB99_RS03030	COG1785	Belongs to the alkaline phosphatase family
DRB99_RS03045	COG1982	Orn Lys Arg decarboxylase major
DRB99_RS03080	COG1609	Transcriptional regulator
DRB99_RS03100	COG1874	Beta-galactosidase
DRB99_RS03105	COG3290	protein histidine kinase activity
DRB99_RS03105	COG0840	transmembrane signaling receptor activity
DRB99_RS03110	COG2972	Histidine kinase
DRB99_RS03115	COG4753	response regulator
DRB99_RS03115	COG2207	Transcriptional regulator
DRB99_RS03130	COG2207	Transcriptional regulator
DRB99_RS03180	COG0028	Belongs to the TPP enzyme family
DRB99_RS03180	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
DRB99_RS03185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DRB99_RS03200	COG3290	protein histidine kinase activity
DRB99_RS03215	COG0493	'glutamate synthase
DRB99_RS03215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DRB99_RS03225	COG0840	transmembrane signaling receptor activity
DRB99_RS03245	COG3711	transcriptional antiterminator
DRB99_RS03250	COG2190	(PTS) system
DRB99_RS03250	COG1263	PTS System
DRB99_RS03250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS03255	COG0613	PHP domain protein
DRB99_RS03270	COG1063	alcohol dehydrogenase
DRB99_RS03280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DRB99_RS03280	COG0493	'glutamate synthase
DRB99_RS03285	COG2814	Major facilitator Superfamily
DRB99_RS03295	COG3142	Participates in the control of copper homeostasis
DRB99_RS03300	COG5002	protein histidine kinase activity
DRB99_RS03300	COG0642	Histidine kinase
DRB99_RS03305	COG0745	RESPONSE REGULATOR receiver
DRB99_RS03310	COG0398	Pfam SNARE associated Golgi protein
DRB99_RS03315	COG1183	phosphatidylcholine synthase activity
DRB99_RS03320	COG3290	protein histidine kinase activity
DRB99_RS03325	COG3279	Response regulator of the LytR AlgR family
DRB99_RS03335	COG1131	(ABC) transporter
DRB99_RS03350	COG3655	Transcriptional regulator
DRB99_RS03375	COG2731	YhcH YjgK YiaL family protein
DRB99_RS03400	COG0583	DNA-binding transcription factor activity
DRB99_RS03410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DRB99_RS03420	COG1115	amino acid carrier protein
DRB99_RS03425	COG1254	Belongs to the acylphosphatase family
DRB99_RS03430	COG0105	UTP biosynthetic process
DRB99_RS03440	COG1177	transmembrane transport
DRB99_RS03445	COG1176	ABC-type spermidine putrescine transport system, permease component I
DRB99_RS03465	COG1115	amino acid carrier protein
DRB99_RS03470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DRB99_RS03485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DRB99_RS03495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DRB99_RS03500	COG1739	Uncharacterized protein family UPF0029
DRB99_RS03510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DRB99_RS03520	COG1459	type II secretion system
DRB99_RS03570	COG0527	aspartate kinase activity
DRB99_RS03575	COG0004	ammonium transporteR
DRB99_RS03580	COG0347	Belongs to the P(II) protein family
DRB99_RS03595	COG0067	glutamate synthase
DRB99_RS03595	COG0069	glutamate synthase activity
DRB99_RS03595	COG0070	glutamate synthase
DRB99_RS03600	COG0493	'glutamate synthase
DRB99_RS03615	COG0583	DNA-binding transcription factor activity
DRB99_RS03625	COG0538	isocitrate dehydrogenase activity
DRB99_RS03665	COG2309	aminopeptidase activity
DRB99_RS03670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DRB99_RS03670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DRB99_RS03680	COG0741	lytic transglycosylase activity
DRB99_RS03710	COG2199	diguanylate cyclase activity
DRB99_RS03710	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DRB99_RS03715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DRB99_RS03715	COG0512	Glutamine amidotransferase of anthranilate synthase
DRB99_RS03720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DRB99_RS03725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DRB99_RS03745	COG2205	protein histidine kinase activity
DRB99_RS03745	COG0745	RESPONSE REGULATOR receiver
DRB99_RS03745	COG3292	Two component regulator propeller
DRB99_RS03750	COG5002	protein histidine kinase activity
DRB99_RS03755	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DRB99_RS03765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DRB99_RS03770	COG1116	anion transmembrane transporter activity
DRB99_RS03775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DRB99_RS03795	COG1686	Belongs to the peptidase S11 family
DRB99_RS03805	COG3442	glutamine amidotransferase
DRB99_RS03810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DRB99_RS03820	COG0826	peptidase U32
DRB99_RS03825	COG1193	negative regulation of DNA recombination
DRB99_RS03830	COG1683	Conserved Protein
DRB99_RS03835	COG0531	amino acid
DRB99_RS03845	COG0420	3'-5' exonuclease activity
DRB99_RS03850	COG0419	ATPase involved in DNA repair
DRB99_RS03855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DRB99_RS03860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DRB99_RS03865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DRB99_RS03875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DRB99_RS03880	COG0728	peptidoglycan biosynthetic process
DRB99_RS03890	COG0438	transferase activity, transferring glycosyl groups
DRB99_RS03915	COG0012	GTP binding
DRB99_RS03930	COG1968	undecaprenyl-diphosphatase activity
DRB99_RS03945	COG0540	Belongs to the ATCase OTCase family
DRB99_RS03960	COG0284	orotidine-5'-phosphate decarboxylase activity
DRB99_RS03970	COG0167	dihydroorotate dehydrogenase activity
DRB99_RS03975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DRB99_RS03980	COG1882	Formate acetyltransferase
DRB99_RS04015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DRB99_RS04015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DRB99_RS04020	COG4632	Exopolysaccharide biosynthesis protein
DRB99_RS04020	COG5434	Belongs to the glycosyl hydrolase 28 family
DRB99_RS04030	COG1994	Peptidase M50
DRB99_RS04035	COG0018	arginyl-trna synthetase
DRB99_RS04060	COG2333	competence protein COMEC
DRB99_RS04060	COG0658	competence protein
DRB99_RS04075	COG2155	Conserved Protein
DRB99_RS04080	COG1522	sequence-specific DNA binding
DRB99_RS04110	COG0697	spore germination
DRB99_RS04115	COG0367	asparagine synthase
DRB99_RS04130	COG1728	Protein conserved in bacteria
DRB99_RS04155	COG1132	(ABC) transporter
DRB99_RS04165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DRB99_RS04170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DRB99_RS04170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DRB99_RS04185	COG1301	dicarboxylic acid transport
DRB99_RS04195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DRB99_RS04200	COG0765	amino acid transport
DRB99_RS04205	COG1126	abc transporter atp-binding protein
DRB99_RS04215	COG0038	chloride channel
DRB99_RS04220	COG1595	DNA-templated transcription, initiation
DRB99_RS04230	COG1027	Aspartate ammonia-lyase
DRB99_RS04240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DRB99_RS04250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DRB99_RS04255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DRB99_RS04260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DRB99_RS04265	COG0138	bifunctional purine biosynthesis protein purh
DRB99_RS04270	COG0151	Belongs to the GarS family
DRB99_RS04280	COG5002	protein histidine kinase activity
DRB99_RS04285	COG0393	Putative heavy-metal-binding
DRB99_RS04310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DRB99_RS04320	COG2070	2-Nitropropane dioxygenase
DRB99_RS04325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DRB99_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
DRB99_RS04335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DRB99_RS04340	COG0511	ligase activity, forming carbon-carbon bonds
DRB99_RS04350	COG0439	Biotin carboxylase
DRB99_RS04355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DRB99_RS04360	COG0825	malonyl-CoA metabolic process
DRB99_RS04375	COG4120	Belongs to the binding-protein-dependent transport system permease family
DRB99_RS04385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DRB99_RS04390	COG1959	2 iron, 2 sulfur cluster binding
DRB99_RS04405	COG0482	sulfurtransferase activity
DRB99_RS04415	COG0628	permease
DRB99_RS04420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DRB99_RS04425	COG4472	Bacterial protein of unknown function (DUF965)
DRB99_RS04430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DRB99_RS04440	COG0735	belongs to the Fur family
DRB99_RS04445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DRB99_RS04455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DRB99_RS04460	COG4122	O-methyltransferase activity
DRB99_RS04490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DRB99_RS04500	COG1191	sigma factor activity
DRB99_RS04505	COG1191	sigma factor activity
DRB99_RS04510	COG1873	PFAM PRC-barrel domain
DRB99_RS04515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DRB99_RS04525	COG0745	RESPONSE REGULATOR receiver
DRB99_RS04530	COG5002	protein histidine kinase activity
DRB99_RS04535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DRB99_RS04540	COG0573	inorganic phosphate transmembrane transporter activity
DRB99_RS04545	COG0581	inorganic phosphate transmembrane transporter activity
DRB99_RS04550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DRB99_RS04570	COG1160	GTP binding
DRB99_RS04575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DRB99_RS04580	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DRB99_RS04595	COG2252	PERMEase
DRB99_RS04600	COG1561	YicC-like family, N-terminal region
DRB99_RS04615	COG1758	RNA polymerase activity
DRB99_RS04620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DRB99_RS04625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DRB99_RS04635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DRB99_RS04640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DRB99_RS04640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DRB99_RS04645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DRB99_RS04650	COG0631	protein serine/threonine phosphatase activity
DRB99_RS04660	COG1162	GTPase activity
DRB99_RS04665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DRB99_RS04675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DRB99_RS04685	COG1461	Dihydroxyacetone kinase
DRB99_RS04690	COG1609	Transcriptional regulator
DRB99_RS04695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DRB99_RS04700	COG0742	ribosomal rna small subunit methyltransferase
DRB99_RS04705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DRB99_RS04720	COG1323	Belongs to the UPF0348 family
DRB99_RS04725	COG0280	phosphate acetyltransferase
DRB99_RS04730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DRB99_RS04745	COG0416	fatty acid biosynthetic process
DRB99_RS04755	COG0571	ribonuclease III activity
DRB99_RS04770	COG0552	protein localization to endoplasmic reticulum
DRB99_RS04775	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DRB99_RS04780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DRB99_RS04785	COG0228	four-way junction DNA binding
DRB99_RS04795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DRB99_RS04800	COG0336	Belongs to the RNA methyltransferase TrmD family
DRB99_RS04805	COG0335	large ribosomal subunit rRNA binding
DRB99_RS04815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DRB99_RS04825	COG0606	chelatase, subunit chli
DRB99_RS04830	COG0758	DNA mediated transformation
DRB99_RS04835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DRB99_RS04840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DRB99_RS04845	COG0052	Belongs to the universal ribosomal protein uS2 family
DRB99_RS04855	COG0528	UMP kinase activity
DRB99_RS04870	COG4589	Belongs to the CDS family
DRB99_RS04875	COG0628	permease
DRB99_RS04905	COG0195	Participates in both transcription termination and antitermination
DRB99_RS04910	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DRB99_RS04920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DRB99_RS04925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DRB99_RS04940	COG0196	riboflavin kinase activity
DRB99_RS04945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DRB99_RS04950	COG1185	polyribonucleotide nucleotidyltransferase activity
DRB99_RS04955	COG0612	Peptidase, M16
DRB99_RS04965	COG0527	aspartate kinase activity
DRB99_RS04970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DRB99_RS04985	COG0110	maltose O-acetyltransferase activity
DRB99_RS04990	COG3711	transcriptional antiterminator
DRB99_RS04995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS04995	COG1263	PTS System
DRB99_RS04995	COG2190	(PTS) system
DRB99_RS05005	COG0740	serine-type endopeptidase activity
DRB99_RS05015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DRB99_RS05020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DRB99_RS05025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DRB99_RS05030	COG1418	mRNA catabolic process
DRB99_RS05035	COG2359	stage V sporulation protein S
DRB99_RS05040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DRB99_RS05045	COG2155	Conserved Protein
DRB99_RS05050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DRB99_RS05075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DRB99_RS05075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DRB99_RS05080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DRB99_RS05090	COG1773	rubredoxin
DRB99_RS05090	COG1592	Rubrerythrin
DRB99_RS05095	COG2274	protein secretion by the type I secretion system
DRB99_RS05095	COG3271	cysteine-type peptidase activity
DRB99_RS05120	COG0348	domain, Protein
DRB99_RS05135	COG0745	RESPONSE REGULATOR receiver
DRB99_RS05140	COG2770	Histidine kinase
DRB99_RS05140	COG2205	protein histidine kinase activity
DRB99_RS05145	COG2364	Membrane
DRB99_RS05155	COG0347	Belongs to the P(II) protein family
DRB99_RS05160	COG1840	ABC-type Fe3 transport system, periplasmic component
DRB99_RS05165	COG3842	ATPase activity
DRB99_RS05170	COG1176	ABC-type spermidine putrescine transport system, permease component I
DRB99_RS05175	COG1177	transmembrane transport
DRB99_RS05180	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DRB99_RS05185	COG1012	belongs to the aldehyde dehydrogenase family
DRB99_RS05205	COG1454	alcohol dehydrogenase
DRB99_RS05250	COG0534	Mate efflux family protein
DRB99_RS05260	COG0037	tRNA processing
DRB99_RS05270	COG0475	glutathione-regulated potassium exporter activity
DRB99_RS05295	COG0745	RESPONSE REGULATOR receiver
DRB99_RS05295	COG2205	protein histidine kinase activity
DRB99_RS05295	COG3292	Two component regulator propeller
DRB99_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
DRB99_RS05320	COG5002	protein histidine kinase activity
DRB99_RS05325	COG0745	RESPONSE REGULATOR receiver
DRB99_RS05330	COG0612	Peptidase, M16
DRB99_RS05355	COG5434	Belongs to the glycosyl hydrolase 28 family
DRB99_RS05355	COG4632	Exopolysaccharide biosynthesis protein
DRB99_RS05365	COG0534	Mate efflux family protein
DRB99_RS05385	COG0446	pyridine nucleotide-disulphide oxidoreductase
DRB99_RS05405	COG1619	proteins homologs of microcin C7 resistance protein MccF
DRB99_RS05410	COG1550	Protein conserved in bacteria
DRB99_RS05420	COG0861	Integral membrane protein TerC family
DRB99_RS05460	COG1523	belongs to the glycosyl hydrolase 13 family
DRB99_RS05465	COG2171	N-acyltransferase activity
DRB99_RS05470	COG0436	Aminotransferase
DRB99_RS05480	COG0601	transmembrane transport
DRB99_RS05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DRB99_RS05490	COG0444	Belongs to the ABC transporter superfamily
DRB99_RS05495	COG4608	Belongs to the ABC transporter superfamily
DRB99_RS05500	COG4166	transmembrane transport
DRB99_RS05510	COG3608	succinylglutamate desuccinylase aspartoacylase
DRB99_RS05520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DRB99_RS05525	COG0747	negative chemotaxis
DRB99_RS05530	COG0444	Belongs to the ABC transporter superfamily
DRB99_RS05535	COG4608	Belongs to the ABC transporter superfamily
DRB99_RS05545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DRB99_RS05555	COG2226	methyltransferase
DRB99_RS05560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DRB99_RS05565	COG0840	transmembrane signaling receptor activity
DRB99_RS05575	COG1834	amidinotransferase
DRB99_RS05580	COG1396	sequence-specific DNA binding
DRB99_RS05600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DRB99_RS05610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DRB99_RS05615	COG2201	protein-glutamate methylesterase activity
DRB99_RS05620	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DRB99_RS05650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DRB99_RS05655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DRB99_RS05660	COG0569	domain protein
DRB99_RS05665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DRB99_RS05670	COG2081	HI0933 family
DRB99_RS05690	COG0726	polysaccharide deacetylase
DRB99_RS05705	COG1132	(ABC) transporter
DRB99_RS05715	COG3830	Belongs to the UPF0237 family
DRB99_RS05720	COG2848	UPF0210 protein
DRB99_RS05750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DRB99_RS05755	COG0708	Exodeoxyribonuclease III
DRB99_RS05775	COG1234	tRNA 3'-trailer cleavage
DRB99_RS05800	COG0840	transmembrane signaling receptor activity
DRB99_RS05820	COG4753	response regulator
DRB99_RS05820	COG2207	Transcriptional regulator
DRB99_RS05825	COG2972	Histidine kinase
DRB99_RS05835	COG1175	transmembrane transport
DRB99_RS05840	COG3833	ABC-type maltose transport systems, permease component
DRB99_RS05855	COG1523	belongs to the glycosyl hydrolase 13 family
DRB99_RS05875	COG0602	queuosine metabolic process
DRB99_RS05880	COG0302	gtp cyclohydrolase
DRB99_RS05885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DRB99_RS05890	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DRB99_RS05905	COG1132	(ABC) transporter
DRB99_RS05910	COG1132	(ABC) transporter
DRB99_RS05935	COG1686	Belongs to the peptidase S11 family
DRB99_RS05945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DRB99_RS05950	COG3874	Sporulation protein YtfJ
DRB99_RS05960	COG1686	Belongs to the peptidase S11 family
DRB99_RS05975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DRB99_RS05980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DRB99_RS05985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DRB99_RS05990	COG2188	Transcriptional regulator
DRB99_RS06010	COG3627	carbon phosphorus lyase activity
DRB99_RS06015	COG4107	phosphonate C-P lyase system protein PhnK
DRB99_RS06020	COG3454	Phosphonate metabolism
DRB99_RS06025	COG4778	phosphonate C-P lyase system protein PhnL
DRB99_RS06030	COG0613	PHP domain protein
DRB99_RS06040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DRB99_RS06050	COG3639	organic phosphonate transmembrane transporter activity
DRB99_RS06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DRB99_RS06065	COG1566	PFAM secretion protein HlyD family protein
DRB99_RS06070	COG1132	(ABC) transporter
DRB99_RS06100	COG1193	negative regulation of DNA recombination
DRB99_RS06130	COG1396	sequence-specific DNA binding
DRB99_RS06155	COG0419	ATPase involved in DNA repair
DRB99_RS06350	COG0791	NLP P60 protein
DRB99_RS06405	COG5632	N-Acetylmuramoyl-L-alanine amidase
DRB99_RS06405	COG5263	repeat protein
DRB99_RS06435	COG2333	competence protein COMEC
DRB99_RS06435	COG0658	competence protein
DRB99_RS06445	COG3875	lactate racemase activity
DRB99_RS06450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DRB99_RS06455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DRB99_RS06460	COG4208	sulfate ABC transporter
DRB99_RS06475	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
DRB99_RS06480	COG0175	sulfate reduction
DRB99_RS06510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DRB99_RS06520	COG0778	Nitroreductase
DRB99_RS06530	COG2086	electron transfer activity
DRB99_RS06535	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DRB99_RS06540	COG1620	l-lactate permease
DRB99_RS06545	COG0277	FAD linked oxidase domain protein
DRB99_RS06550	COG1960	acyl-CoA dehydrogenase activity
DRB99_RS06600	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DRB99_RS06605	COG0402	S-adenosylhomocysteine deaminase activity
DRB99_RS06640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DRB99_RS06695	COG0305	Participates in initiation and elongation during chromosome replication
DRB99_RS06710	COG3177	Filamentation induced by cAMP protein fic
DRB99_RS06715	COG1840	ABC-type Fe3 transport system, periplasmic component
DRB99_RS06720	COG3842	ATPase activity
DRB99_RS06735	COG4753	response regulator
DRB99_RS06735	COG2207	Transcriptional regulator
DRB99_RS06750	COG0494	nUDIX hydrolase
DRB99_RS06775	COG1473	amidohydrolase
DRB99_RS06780	COG0737	Belongs to the 5'-nucleotidase family
DRB99_RS06830	COG0406	alpha-ribazole phosphatase activity
DRB99_RS06835	COG1368	sulfuric ester hydrolase activity
DRB99_RS06855	COG0561	phosphatase activity
DRB99_RS06865	COG3706	GGDEF domain
DRB99_RS06870	COG0667	Aldo Keto reductase
DRB99_RS06885	COG1725	Transcriptional regulator
DRB99_RS06890	COG1131	(ABC) transporter
DRB99_RS06935	COG0668	transmembrane transport
DRB99_RS06955	COG0531	amino acid
DRB99_RS06965	COG0561	phosphatase activity
DRB99_RS06980	COG2195	Cleaves the N-terminal amino acid of tripeptides
DRB99_RS06990	COG3842	ATPase activity
DRB99_RS06995	COG0719	Fe-S assembly protein
DRB99_RS07030	COG0039	L-malate dehydrogenase activity
DRB99_RS07045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DRB99_RS07050	COG4605	iron ion homeostasis
DRB99_RS07055	COG4604	ABC transporter, ATP-binding protein
DRB99_RS07060	COG4607	ABC-type enterochelin transport system periplasmic component
DRB99_RS07065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DRB99_RS07100	COG2208	phosphoserine phosphatase activity
DRB99_RS07105	COG2226	methyltransferase
DRB99_RS07110	COG1283	sodium-dependent phosphate transmembrane transporter activity
DRB99_RS07115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DRB99_RS07140	COG0569	domain protein
DRB99_RS07145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DRB99_RS07150	COG1187	pseudouridine synthase activity
DRB99_RS07170	COG0768	penicillin binding
DRB99_RS07175	COG2205	protein histidine kinase activity
DRB99_RS07175	COG3292	Two component regulator propeller
DRB99_RS07175	COG0745	RESPONSE REGULATOR receiver
DRB99_RS07200	COG1329	Transcriptional regulator
DRB99_RS07205	COG1619	proteins homologs of microcin C7 resistance protein MccF
DRB99_RS07220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DRB99_RS07225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DRB99_RS07235	COG1363	Peptidase, m42
DRB99_RS07265	COG3617	BRO family, N-terminal domain
DRB99_RS07280	COG2002	toxin-antitoxin pair type II binding
DRB99_RS07370	COG3546	catalase activity
DRB99_RS07630	COG0523	cobalamin synthesis protein
DRB99_RS07640	COG0701	Predicted permease
DRB99_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
DRB99_RS07705	COG0454	-acetyltransferase
DRB99_RS07730	COG0789	Transcriptional regulator
DRB99_RS07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DRB99_RS07750	COG0765	amino acid transport
DRB99_RS07765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DRB99_RS07775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DRB99_RS07780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DRB99_RS07795	COG4716	Myosin-crossreactive antigen
DRB99_RS07810	COG3835	regulator
DRB99_RS07815	COG2610	gluconate transmembrane transporter activity
DRB99_RS07820	COG1929	Belongs to the glycerate kinase type-1 family
DRB99_RS07830	COG1376	ErfK ybiS ycfS ynhG family protein
DRB99_RS07835	COG2081	HI0933 family
DRB99_RS07845	COG0539	negative regulation of cytoplasmic translation
DRB99_RS07845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DRB99_RS07860	COG0523	cobalamin synthesis protein
DRB99_RS07885	COG3328	transposase activity
DRB99_RS07890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DRB99_RS07895	COG4974	Belongs to the 'phage' integrase family
DRB99_RS07915	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DRB99_RS07920	COG0028	Belongs to the TPP enzyme family
DRB99_RS07925	COG1923	regulation of RNA biosynthetic process
DRB99_RS07930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DRB99_RS07935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DRB99_RS07955	COG2252	PERMEase
DRB99_RS07970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DRB99_RS07985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DRB99_RS08000	COG0577	efflux transmembrane transporter activity
DRB99_RS08005	COG1136	(ABC) transporter
DRB99_RS08020	COG5002	protein histidine kinase activity
DRB99_RS08025	COG0534	Mate efflux family protein
DRB99_RS08035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DRB99_RS08045	COG3584	3D domain protein
DRB99_RS08045	COG1388	LysM domain
DRB99_RS08050	COG4399	Belongs to the UPF0754 family
DRB99_RS08060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DRB99_RS08065	COG1283	sodium-dependent phosphate transmembrane transporter activity
DRB99_RS08070	COG1285	pathogenesis
DRB99_RS08075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DRB99_RS08085	COG0488	(ABC) transporter
DRB99_RS08110	COG0133	tryptophan synthase activity
DRB99_RS08115	COG0135	phosphoribosylanthranilate isomerase activity
DRB99_RS08120	COG0134	indole-3-glycerol-phosphate synthase activity
DRB99_RS08125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DRB99_RS08130	COG0512	Glutamine amidotransferase of anthranilate synthase
DRB99_RS08130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DRB99_RS08215	COG1141	Ferredoxin
DRB99_RS08225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DRB99_RS08250	COG1349	DNA-binding transcription factor activity
DRB99_RS08255	COG0561	phosphatase activity
DRB99_RS08275	COG0798	PFAM Bile acid sodium symporter
DRB99_RS08295	COG0640	Transcriptional regulator
DRB99_RS08305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DRB99_RS08315	COG2201	protein-glutamate methylesterase activity
DRB99_RS08325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DRB99_RS08335	COG0561	phosphatase activity
DRB99_RS08360	COG1879	ABC-type sugar transport system periplasmic component
DRB99_RS08365	COG1879	ABC-type sugar transport system periplasmic component
DRB99_RS08375	COG1404	Belongs to the peptidase S8 family
DRB99_RS08390	COG0494	nUDIX hydrolase
DRB99_RS08395	COG4708	membrane
DRB99_RS08415	COG0534	Mate efflux family protein
DRB99_RS08440	COG1285	pathogenesis
DRB99_RS08460	COG1533	DNA photolyase activity
DRB99_RS08490	COG0657	acetylesterase activity
DRB99_RS08490	COG2755	lipolytic protein G-D-S-L family
DRB99_RS08505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DRB99_RS08560	COG1660	Displays ATPase and GTPase activities
DRB99_RS08580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DRB99_RS08580	COG1199	ATP-dependent helicase activity
DRB99_RS08625	COG0305	Participates in initiation and elongation during chromosome replication
DRB99_RS08655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DRB99_RS08755	COG1231	oxidoreductase activity
DRB99_RS08765	COG0662	Cupin 2, conserved barrel domain protein
DRB99_RS08785	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DRB99_RS08790	COG1253	flavin adenine dinucleotide binding
DRB99_RS08810	COG0693	protein deglycase activity
DRB99_RS08820	COG1733	regulation of RNA biosynthetic process
DRB99_RS08850	COG0494	nUDIX hydrolase
DRB99_RS08895	COG3708	Transcriptional regulator
DRB99_RS08895	COG2207	Transcriptional regulator
DRB99_RS08905	COG0693	protein deglycase activity
DRB99_RS08915	COG0488	(ABC) transporter
DRB99_RS08920	COG0789	Transcriptional regulator
DRB99_RS08930	COG0789	Transcriptional regulator
DRB99_RS08980	COG1131	(ABC) transporter
DRB99_RS09000	COG0534	Mate efflux family protein
DRB99_RS09005	COG0390	transport system, permease component
DRB99_RS09010	COG4619	ABC transporter
DRB99_RS09040	COG1725	Transcriptional regulator
DRB99_RS09050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DRB99_RS09050	COG2080	2 iron, 2 sulfur cluster binding
DRB99_RS09080	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DRB99_RS09080	COG3608	succinylglutamate desuccinylase aspartoacylase
DRB99_RS09085	COG3608	succinylglutamate desuccinylase aspartoacylase
DRB99_RS09085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DRB99_RS09090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DRB99_RS09100	COG1396	sequence-specific DNA binding
DRB99_RS09105	COG0697	spore germination
DRB99_RS09110	COG1408	metallophosphoesterase
DRB99_RS09135	COG0395	ABC-type sugar transport system, permease component
DRB99_RS09145	COG1653	transport
DRB99_RS09150	COG0366	Alpha amylase catalytic
DRB99_RS09180	COG0277	FAD linked oxidase domain protein
DRB99_RS09185	COG2011	ABC-type metal ion transport system permease component
DRB99_RS09190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DRB99_RS09200	COG0436	Aminotransferase
DRB99_RS09205	COG0626	cystathionine gamma-synthase activity
DRB99_RS09210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DRB99_RS09215	COG0387	Pfam Sodium calcium exchanger
DRB99_RS09220	COG0464	growth
DRB99_RS09225	COG0406	alpha-ribazole phosphatase activity
DRB99_RS09265	COG0436	Aminotransferase
DRB99_RS09270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DRB99_RS09280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DRB99_RS09305	COG0835	chemotaxis
DRB99_RS09305	COG0784	Response regulator, receiver
DRB99_RS09330	COG0745	RESPONSE REGULATOR receiver
DRB99_RS09335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DRB99_RS09345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DRB99_RS09360	COG0124	histidyl-tRNA synthetase
DRB99_RS09365	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DRB99_RS09370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DRB99_RS09395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DRB99_RS09395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DRB99_RS09395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DRB99_RS09400	COG1105	Belongs to the carbohydrate kinase PfkB family
DRB99_RS09405	COG1349	DNA-binding transcription factor activity
DRB99_RS09420	COG2211	Major facilitator Superfamily
DRB99_RS09435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DRB99_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
DRB99_RS09450	COG2721	sulfolactate sulfo-lyase activity
DRB99_RS09455	COG0246	Mannitol dehydrogenase
DRB99_RS09460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DRB99_RS09465	COG0800	Aldolase
DRB99_RS09470	COG1904	glucuronate isomerase
DRB99_RS09475	COG1609	Transcriptional regulator
DRB99_RS09480	COG0646	methionine synthase
DRB99_RS09480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DRB99_RS09490	COG1191	sigma factor activity
DRB99_RS09500	COG0484	heat shock protein binding
DRB99_RS09505	COG0514	ATP-dependent DNA helicase (RecQ)
DRB99_RS09510	COG0765	amino acid transport
DRB99_RS09515	COG0765	amino acid transport
DRB99_RS09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DRB99_RS09530	COG0024	Methionine aminopeptidase
DRB99_RS09555	COG2022	thiamine diphosphate biosynthetic process
DRB99_RS09565	COG0352	thiamine-phosphate diphosphorylase activity
DRB99_RS09580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DRB99_RS09585	COG0561	phosphatase activity
DRB99_RS09590	COG0697	spore germination
DRB99_RS09605	COG0534	Mate efflux family protein
DRB99_RS09620	COG0028	Belongs to the TPP enzyme family
DRB99_RS09625	COG0440	acetolactate synthase activity
DRB99_RS09630	COG3304	Inner membrane component domain
DRB99_RS09640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DRB99_RS09645	COG0154	amidase activity
DRB99_RS09650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DRB99_RS09660	COG0017	Asparaginyl-tRNA synthetase
DRB99_RS09675	COG0583	DNA-binding transcription factor activity
DRB99_RS09695	COG0071	Belongs to the small heat shock protein (HSP20) family
DRB99_RS09715	COG0038	chloride channel
DRB99_RS09730	COG5002	protein histidine kinase activity
DRB99_RS09765	COG3546	catalase activity
DRB99_RS09780	COG0785	Cytochrome C biogenesis protein
DRB99_RS09795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DRB99_RS09800	COG3118	belongs to the thioredoxin family
DRB99_RS09805	COG0492	ferredoxin-NADP+ reductase activity
DRB99_RS09810	COG1126	abc transporter atp-binding protein
DRB99_RS09830	COG3546	catalase activity
DRB99_RS09835	COG0494	nUDIX hydrolase
DRB99_RS09855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DRB99_RS09865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DRB99_RS09875	COG5278	phosphoserine phosphatase activity
DRB99_RS09875	COG0840	transmembrane signaling receptor activity
DRB99_RS09890	COG4974	Belongs to the 'phage' integrase family
DRB99_RS09910	COG0411	ABC transporter
DRB99_RS09920	COG0559	Belongs to the binding-protein-dependent transport system permease family
DRB99_RS09930	COG0840	transmembrane signaling receptor activity
DRB99_RS09935	COG0454	-acetyltransferase
DRB99_RS09980	COG0745	RESPONSE REGULATOR receiver
DRB99_RS09985	COG0750	zinc metalloprotease
DRB99_RS09990	COG0497	DNA recombination
DRB99_RS09995	COG1438	arginine binding
DRB99_RS10000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DRB99_RS10005	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DRB99_RS10010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DRB99_RS10015	COG0142	geranyltranstransferase activity
DRB99_RS10020	COG1722	exodeoxyribonuclease VII activity
DRB99_RS10025	COG1570	exodeoxyribonuclease VII activity
DRB99_RS10035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DRB99_RS10040	COG1302	Protein conserved in bacteria
DRB99_RS10080	COG3854	ATPases associated with a variety of cellular activities
DRB99_RS10155	COG1737	Transcriptional regulator
DRB99_RS10160	COG0116	Belongs to the methyltransferase superfamily
DRB99_RS10170	COG0564	pseudouridine synthase activity
DRB99_RS10190	COG1799	cell septum assembly
DRB99_RS10195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DRB99_RS10205	COG3856	small basic protein
DRB99_RS10220	COG0772	Belongs to the SEDS family
DRB99_RS10225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DRB99_RS10230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DRB99_RS10240	COG0768	penicillin binding
DRB99_RS10245	COG0768	penicillin binding
DRB99_RS10255	COG0275	rRNA processing
DRB99_RS10260	COG2001	Belongs to the MraZ family
DRB99_RS10285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DRB99_RS10300	COG1522	sequence-specific DNA binding
DRB99_RS10315	COG0671	phosphoesterase, PA-phosphatase related
DRB99_RS10325	COG2703	oxygen carrier activity
DRB99_RS10330	COG1966	Carbon starvation protein
DRB99_RS10345	COG0432	Pfam Uncharacterised protein family UPF0047
DRB99_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
DRB99_RS10365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DRB99_RS10380	COG0534	Mate efflux family protein
DRB99_RS10400	COG0840	transmembrane signaling receptor activity
DRB99_RS10425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DRB99_RS10425	COG0425	Belongs to the sulfur carrier protein TusA family
DRB99_RS10430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DRB99_RS10435	COG2966	Psort location CytoplasmicMembrane, score
DRB99_RS10465	COG0628	permease
DRB99_RS10480	COG3328	transposase activity
DRB99_RS10490	COG1187	pseudouridine synthase activity
DRB99_RS10515	COG0488	(ABC) transporter
DRB99_RS10525	COG1187	pseudouridine synthase activity
DRB99_RS10540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DRB99_RS10550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DRB99_RS10555	COG0628	permease
DRB99_RS10560	COG0572	uridine kinase
DRB99_RS10570	COG1307	EDD domain protein, DegV family
DRB99_RS10590	COG0446	pyridine nucleotide-disulphide oxidoreductase
DRB99_RS10600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DRB99_RS10605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DRB99_RS10610	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DRB99_RS10615	COG4670	ketone body catabolic process
DRB99_RS10625	COG0584	glycerophosphoryl diester phosphodiesterase
DRB99_RS10630	COG0840	transmembrane signaling receptor activity
DRB99_RS10635	COG0561	phosphatase activity
DRB99_RS10640	COG0460	homoserine dehydrogenase
DRB99_RS10650	COG1316	TRANSCRIPTIONal
DRB99_RS10665	COG1132	(ABC) transporter
DRB99_RS10675	COG3328	transposase activity
DRB99_RS10680	COG4464	protein tyrosine phosphatase activity
DRB99_RS10685	COG0489	protein tyrosine kinase activity
DRB99_RS10720	COG1091	dTDP-4-dehydrorhamnose reductase activity
DRB99_RS10735	COG1442	glycosyl transferase family 8
DRB99_RS10735	COG1216	Glycosyl transferase, family 2
DRB99_RS10760	COG1442	glycosyl transferase family 8
DRB99_RS10760	COG1216	Glycosyl transferase, family 2
DRB99_RS10770	COG0438	transferase activity, transferring glycosyl groups
DRB99_RS10775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DRB99_RS10780	COG3944	biosynthesis protein
DRB99_RS10790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DRB99_RS10800	COG1811	Na channel or pump
DRB99_RS10805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DRB99_RS10810	COG0521	Mo-molybdopterin cofactor biosynthetic process
DRB99_RS10825	COG1763	Mo-molybdopterin cofactor biosynthetic process
DRB99_RS10835	COG0303	'Molybdopterin
DRB99_RS10855	COG0446	pyridine nucleotide-disulphide oxidoreductase
DRB99_RS10865	COG0243	molybdopterin cofactor binding
DRB99_RS10895	COG2199	diguanylate cyclase activity
DRB99_RS10895	COG2203	Gaf domain
DRB99_RS10900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DRB99_RS10905	COG0124	histidyl-tRNA synthetase
DRB99_RS10910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DRB99_RS10915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DRB99_RS10920	COG1490	D-aminoacyl-tRNA deacylase activity
DRB99_RS10925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DRB99_RS10930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DRB99_RS10935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DRB99_RS10935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DRB99_RS10940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DRB99_RS10945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DRB99_RS10955	COG1862	Preprotein translocase
DRB99_RS10965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DRB99_RS10970	COG2255	four-way junction helicase activity
DRB99_RS10975	COG0632	four-way junction helicase activity
DRB99_RS11035	COG1879	ABC-type sugar transport system periplasmic component
DRB99_RS11140	COG0534	Mate efflux family protein
DRB99_RS11145	COG0583	DNA-binding transcription factor activity
DRB99_RS11185	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DRB99_RS11195	COG0647	UMP catabolic process
DRB99_RS11200	COG0366	Alpha amylase catalytic
DRB99_RS11215	COG2182	Extracellular solute-binding protein
DRB99_RS11220	COG2207	Transcriptional regulator
DRB99_RS11220	COG1917	Cupin 2, conserved barrel domain protein
DRB99_RS11225	COG0577	efflux transmembrane transporter activity
DRB99_RS11230	COG1136	(ABC) transporter
DRB99_RS11245	COG0745	RESPONSE REGULATOR receiver
DRB99_RS11255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DRB99_RS11260	COG1592	Rubrerythrin
DRB99_RS11260	COG1773	rubredoxin
DRB99_RS11270	COG0484	heat shock protein binding
DRB99_RS11290	COG0613	PHP domain protein
DRB99_RS11295	COG1362	aminopeptidase activity
DRB99_RS11300	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DRB99_RS11340	COG0646	methionine synthase
DRB99_RS11340	COG1410	methionine synthase
DRB99_RS11350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DRB99_RS11390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DRB99_RS11395	COG1269	ATP hydrolysis coupled proton transport
DRB99_RS11420	COG2244	polysaccharide biosynthetic process
DRB99_RS11425	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS11430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS11430	COG1263	PTS System
DRB99_RS11430	COG2190	(PTS) system
DRB99_RS11435	COG3711	transcriptional antiterminator
DRB99_RS11445	COG0564	pseudouridine synthase activity
DRB99_RS11450	COG1473	amidohydrolase
DRB99_RS11455	COG0849	cell division
DRB99_RS11475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DRB99_RS11490	COG0735	belongs to the Fur family
DRB99_RS11520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DRB99_RS11525	COG1067	ATP-dependent peptidase activity
DRB99_RS11525	COG0470	DNA polymerase III
DRB99_RS11530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DRB99_RS11540	COG0544	peptidyl-prolyl cis-trans isomerase activity
DRB99_RS11555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DRB99_RS11560	COG0140	phosphoribosyl-ATP diphosphatase activity
DRB99_RS11565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DRB99_RS11570	COG0107	imidazoleglycerol-phosphate synthase activity
DRB99_RS11575	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DRB99_RS11580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DRB99_RS11585	COG0131	Imidazoleglycerol-phosphate dehydratase
DRB99_RS11590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DRB99_RS11595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DRB99_RS11600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DRB99_RS11625	COG2084	Dehydrogenase
DRB99_RS11645	COG4492	Belongs to the UPF0735 family
DRB99_RS11650	COG0083	homoserine kinase activity
DRB99_RS11655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DRB99_RS11685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DRB99_RS11690	COG0113	porphobilinogen synthase activity
DRB99_RS11695	COG1587	Uroporphyrinogen-III synthase
DRB99_RS11695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DRB99_RS11710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DRB99_RS11720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DRB99_RS11730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DRB99_RS11735	COG3326	Membrane
DRB99_RS11740	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DRB99_RS11745	COG2706	6-phosphogluconolactonase activity
DRB99_RS11750	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DRB99_RS11760	COG0446	pyridine nucleotide-disulphide oxidoreductase
DRB99_RS11775	COG0561	phosphatase activity
DRB99_RS11795	COG1492	cobalamin metabolic process
DRB99_RS11800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DRB99_RS11845	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DRB99_RS11855	COG1797	cobyrinic acid a,c-diamide synthase activity
DRB99_RS11875	COG0840	transmembrane signaling receptor activity
DRB99_RS11890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DRB99_RS11895	COG1802	Transcriptional regulator
DRB99_RS11905	COG0813	purine-nucleoside phosphorylase activity
DRB99_RS11910	COG3958	Transketolase
DRB99_RS11915	COG3959	Transketolase, thiamine diphosphate binding domain
DRB99_RS11925	COG0295	cytidine deaminase activity
DRB99_RS11930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DRB99_RS11935	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DRB99_RS11950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DRB99_RS11960	COG3958	Transketolase
DRB99_RS11965	COG3959	Transketolase, thiamine diphosphate binding domain
DRB99_RS11975	COG0235	Class ii aldolase
DRB99_RS11990	COG3037	sugar-specific permease SgaT UlaA
DRB99_RS12005	COG1349	DNA-binding transcription factor activity
DRB99_RS12010	COG0733	neurotransmitter:sodium symporter activity
DRB99_RS12040	COG1476	TRANSCRIPTIONal
DRB99_RS12060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DRB99_RS12065	COG4521	taurine ABC transporter
DRB99_RS12070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DRB99_RS12075	COG2508	Transcriptional regulator
DRB99_RS12090	COG2200	EAL domain
DRB99_RS12095	COG0110	maltose O-acetyltransferase activity
DRB99_RS12100	COG0366	Alpha amylase catalytic
DRB99_RS12105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DRB99_RS12120	COG2059	Chromate
DRB99_RS12130	COG0439	Biotin carboxylase
DRB99_RS12135	COG0511	ligase activity, forming carbon-carbon bonds
DRB99_RS12140	COG1984	allophanate hydrolase subunit 2
DRB99_RS12145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DRB99_RS12155	COG1115	amino acid carrier protein
DRB99_RS12160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DRB99_RS12165	COG4336	lyase activity
DRB99_RS12180	COG1522	sequence-specific DNA binding
DRB99_RS12190	COG1846	Transcriptional regulator
DRB99_RS12195	COG0436	Aminotransferase
DRB99_RS12200	COG0733	neurotransmitter:sodium symporter activity
DRB99_RS12235	COG1321	iron dependent repressor
DRB99_RS12245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DRB99_RS12250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DRB99_RS12260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DRB99_RS12270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DRB99_RS12280	COG1523	belongs to the glycosyl hydrolase 13 family
DRB99_RS12285	COG0366	Alpha amylase catalytic
DRB99_RS12290	COG4086	secreted protein
DRB99_RS12305	COG2059	Chromate
DRB99_RS12310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DRB99_RS12315	COG1393	Belongs to the ArsC family
DRB99_RS12320	COG2267	carboxylic ester hydrolase activity
DRB99_RS12325	COG3437	response regulator, receiver
DRB99_RS12330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DRB99_RS12345	COG0813	purine-nucleoside phosphorylase activity
DRB99_RS12350	COG0295	cytidine deaminase activity
DRB99_RS12370	COG1744	ABC transporter substrate-binding protein PnrA-like
DRB99_RS12380	COG0436	Aminotransferase
DRB99_RS12385	COG1522	sequence-specific DNA binding
DRB99_RS12395	COG0542	response to heat
DRB99_RS12400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DRB99_RS12410	COG0733	neurotransmitter:sodium symporter activity
DRB99_RS12415	COG1982	Orn Lys Arg decarboxylase major
DRB99_RS12420	COG0612	Peptidase, M16
DRB99_RS12425	COG0840	transmembrane signaling receptor activity
DRB99_RS12445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DRB99_RS12445	COG2199	diguanylate cyclase activity
DRB99_RS12455	COG1136	(ABC) transporter
DRB99_RS12460	COG2205	protein histidine kinase activity
DRB99_RS12465	COG0745	RESPONSE REGULATOR receiver
DRB99_RS12490	COG0726	polysaccharide deacetylase
DRB99_RS12515	COG0446	pyridine nucleotide-disulphide oxidoreductase
DRB99_RS12520	COG0157	Belongs to the NadC ModD family
DRB99_RS12530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DRB99_RS12535	COG1725	Transcriptional regulator
DRB99_RS12540	COG1131	(ABC) transporter
DRB99_RS12550	COG1151	hydroxylamine reductase activity
DRB99_RS12570	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DRB99_RS12580	COG1349	DNA-binding transcription factor activity
DRB99_RS12595	COG1114	Component of the transport system for branched-chain amino acids
DRB99_RS12600	COG1846	Transcriptional regulator
DRB99_RS12605	COG3118	belongs to the thioredoxin family
DRB99_RS12635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DRB99_RS12660	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DRB99_RS12665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DRB99_RS12670	COG0058	SHG alpha-glucan phosphorylase activity
DRB99_RS12685	COG3835	regulator
DRB99_RS12690	COG3842	ATPase activity
DRB99_RS12740	COG3321	synthase
DRB99_RS12740	COG4221	oxidoreductase activity
DRB99_RS12740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DRB99_RS12740	COG0300	oxidoreductase activity
DRB99_RS12750	COG2814	Major facilitator Superfamily
DRB99_RS12765	COG0697	spore germination
DRB99_RS12860	COG4974	Belongs to the 'phage' integrase family
DRB99_RS12905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DRB99_RS12910	COG0358	DNA primase activity
DRB99_RS12925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DRB99_RS12925	COG0574	Belongs to the PEP-utilizing enzyme family
DRB99_RS12930	COG0517	IMP dehydrogenase activity
DRB99_RS12945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DRB99_RS12950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DRB99_RS12960	COG1480	7TM receptor with intracellular HD hydrolase
DRB99_RS12975	COG1610	YqeY-like protein
DRB99_RS12980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DRB99_RS12985	COG0537	adenosine 5'-monophosphoramidase activity
DRB99_RS12990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DRB99_RS12995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DRB99_RS13000	COG2264	protein methyltransferase activity
DRB99_RS13010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DRB99_RS13020	COG0484	heat shock protein binding
DRB99_RS13025	COG0443	Heat shock 70 kDa protein
DRB99_RS13030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DRB99_RS13035	COG1420	regulation of RNA biosynthetic process
DRB99_RS13040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DRB99_RS13060	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DRB99_RS13065	COG0268	Binds directly to 16S ribosomal RNA
DRB99_RS13080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DRB99_RS13090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DRB99_RS13105	COG2172	sigma factor antagonist activity
DRB99_RS13115	COG1067	ATP-dependent peptidase activity
DRB99_RS13120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DRB99_RS13135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DRB99_RS13150	COG4786	Flagellar basal body rod
DRB99_RS13155	COG4786	Flagellar basal body rod
DRB99_RS13165	COG1191	sigma factor activity
DRB99_RS13175	COG0455	bacterial-type flagellum organization
DRB99_RS13180	COG1419	protein localization to endoplasmic reticulum
DRB99_RS13185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DRB99_RS13190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DRB99_RS13200	COG1338	Plays a role in the flagellum-specific transport system
DRB99_RS13225	COG1582	Flagellar protein (FlbD)
DRB99_RS13230	COG4786	Flagellar basal body rod
DRB99_RS13235	COG4786	Flagellar basal body rod
DRB99_RS13260	COG1157	protein secretion by the type III secretion system
DRB99_RS13270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DRB99_RS13275	COG1766	The M ring may be actively involved in energy transduction
DRB99_RS13280	COG1677	Flagellar hook-basal body complex protein FliE
DRB99_RS13290	COG1815	bacterial-type flagellum-dependent cell motility
DRB99_RS13295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DRB99_RS13320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DRB99_RS13340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DRB99_RS13345	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DRB99_RS13350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DRB99_RS13355	COG4786	Flagellar basal body rod
DRB99_RS13355	COG1256	bacterial-type flagellum assembly
DRB99_RS13370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DRB99_RS13370	COG1776	CheC inhibitor of MCP methylation
DRB99_RS13375	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DRB99_RS13385	COG2201	protein-glutamate methylesterase activity
DRB99_RS13390	COG1776	CheC inhibitor of MCP methylation
DRB99_RS13395	COG2198	Histidine kinase
DRB99_RS13395	COG0643	Histidine kinase
DRB99_RS13400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DRB99_RS13405	COG2201	protein-glutamate methylesterase activity
DRB99_RS13415	COG0835	chemotaxis
DRB99_RS13435	COG0436	Aminotransferase
DRB99_RS13450	COG0655	NAD(P)H dehydrogenase (quinone) activity
DRB99_RS13455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DRB99_RS13460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DRB99_RS13460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DRB99_RS13470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DRB99_RS13475	COG0187	DNA topoisomerase II activity
DRB99_RS13480	COG1215	transferase activity, transferring glycosyl groups
DRB99_RS13485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DRB99_RS13495	COG0457	Tetratricopeptide repeat
DRB99_RS13495	COG0705	Rhomboid family
DRB99_RS13500	COG1164	Oligoendopeptidase f
DRB99_RS13515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DRB99_RS13520	COG1696	Membrane protein involved in D-alanine export
DRB99_RS13530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DRB99_RS13535	COG1121	(ABC) transporter
DRB99_RS13540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DRB99_RS13545	COG0735	belongs to the Fur family
DRB99_RS13550	COG1971	Probably functions as a manganese efflux pump
DRB99_RS13555	COG0205	6-phosphofructokinase activity
DRB99_RS13560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DRB99_RS13575	COG1309	transcriptional regulator
DRB99_RS13580	COG0488	(ABC) transporter
DRB99_RS13585	COG0756	dUTP diphosphatase activity
DRB99_RS13595	COG2203	Gaf domain
DRB99_RS13595	COG2199	diguanylate cyclase activity
DRB99_RS13605	COG2233	PERMEase
DRB99_RS13630	COG0037	tRNA processing
DRB99_RS13640	COG4684	Psort location CytoplasmicMembrane, score
DRB99_RS13650	COG0745	RESPONSE REGULATOR receiver
DRB99_RS13655	COG2205	protein histidine kinase activity
DRB99_RS13690	COG2376	Dihydroxyacetone kinase
DRB99_RS13700	COG2268	Band 7 protein
DRB99_RS13730	COG1464	Belongs to the NlpA lipoprotein family
DRB99_RS13735	COG2011	ABC-type metal ion transport system permease component
DRB99_RS13740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DRB99_RS13745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DRB99_RS13750	COG0557	exoribonuclease II activity
DRB99_RS13770	COG3152	Membrane
DRB99_RS13775	COG0148	phosphopyruvate hydratase activity
DRB99_RS13790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DRB99_RS13795	COG0149	triose-phosphate isomerase activity
DRB99_RS13800	COG0126	phosphoglycerate kinase activity
DRB99_RS13805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DRB99_RS13810	COG2390	Transcriptional regulator
DRB99_RS13815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DRB99_RS13825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DRB99_RS13830	COG2720	vancomycin resistance protein
DRB99_RS13840	COG5002	protein histidine kinase activity
DRB99_RS13850	COG1181	Belongs to the D-alanine--D-alanine ligase family
DRB99_RS13855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DRB99_RS13865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DRB99_RS13870	COG1045	serine acetyltransferase
DRB99_RS13875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DRB99_RS13880	COG2239	Acts as a magnesium transporter
DRB99_RS13900	COG1597	lipid kinase activity
DRB99_RS13905	COG1183	phosphatidylcholine synthase activity
DRB99_RS13920	COG1592	Rubrerythrin
DRB99_RS13925	COG2719	SpoVR family
DRB99_RS13930	COG2718	Belongs to the UPF0229 family
DRB99_RS13935	COG2766	serine protein kinase
DRB99_RS13940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DRB99_RS13950	COG1442	glycosyl transferase family 8
DRB99_RS13955	COG1216	Glycosyl transferase, family 2
DRB99_RS13960	COG1442	glycosyl transferase family 8
DRB99_RS13965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DRB99_RS13970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DRB99_RS13980	COG0772	Belongs to the SEDS family
DRB99_RS14085	COG1555	photosystem II stabilization
DRB99_RS14090	COG1686	Belongs to the peptidase S11 family
DRB99_RS14095	COG0564	pseudouridine synthase activity
DRB99_RS14100	COG1316	TRANSCRIPTIONal
DRB99_RS14105	COG1713	HD superfamily hydrolase involved in NAD metabolism
DRB99_RS14110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DRB99_RS14115	COG1534	Rna-binding protein
DRB99_RS14120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DRB99_RS14125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DRB99_RS14135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DRB99_RS14140	COG1530	ribonuclease E activity
DRB99_RS14170	COG0772	Belongs to the SEDS family
DRB99_RS14175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DRB99_RS14180	COG2894	cell division
DRB99_RS14190	COG1489	DNA binding
DRB99_RS14205	COG1792	Involved in formation and maintenance of cell shape
DRB99_RS14210	COG1077	Cell shape determining protein MreB Mrl
DRB99_RS14215	COG2003	Belongs to the UPF0758 family
DRB99_RS14220	COG0424	maF-like protein
DRB99_RS14235	COG2195	Cleaves the N-terminal amino acid of tripeptides
DRB99_RS14245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DRB99_RS14245	COG0539	negative regulation of cytoplasmic translation
DRB99_RS14260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DRB99_RS14265	COG0670	Belongs to the BI1 family
DRB99_RS14275	COG0803	Belongs to the bacterial solute-binding protein 9 family
DRB99_RS14310	COG0251	oxidation-reduction process
DRB99_RS14335	COG0802	atpase or kinase
DRB99_RS14340	COG1214	PFAM Peptidase M22, glycoprotease
DRB99_RS14345	COG0456	acetyltransferase
DRB99_RS14360	COG2183	response to ionizing radiation
DRB99_RS14370	COG5002	protein histidine kinase activity
DRB99_RS14395	COG0653	protein targeting
DRB99_RS14400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DRB99_RS14405	COG1040	competence protein
DRB99_RS14415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DRB99_RS14475	COG1609	Transcriptional regulator
DRB99_RS14485	COG2385	sporulation resulting in formation of a cellular spore
DRB99_RS14505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DRB99_RS14525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DRB99_RS14530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DRB99_RS14535	COG0356	it plays a direct role in the translocation of protons across the membrane
DRB99_RS14545	COG0183	Belongs to the thiolase family
DRB99_RS14550	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DRB99_RS14560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DRB99_RS14565	COG0698	ribose 5-phosphate isomerase
DRB99_RS14570	COG0009	L-threonylcarbamoyladenylate synthase
DRB99_RS14580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DRB99_RS14590	COG1435	thymidine kinase activity
DRB99_RS14595	COG0254	rRNA binding
DRB99_RS14600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DRB99_RS14605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DRB99_RS14610	COG0504	CTP synthase activity
DRB99_RS14635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DRB99_RS14645	COG4242	Belongs to the peptidase S51 family
DRB99_RS14650	COG1388	LysM domain
DRB99_RS14650	COG0791	NLP P60 protein
DRB99_RS14655	COG4466	Protein conserved in bacteria
DRB99_RS14705	COG1447	Phosphotransferase system cellobiose-specific component IIA
DRB99_RS14710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DRB99_RS14720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DRB99_RS14745	COG0312	modulator of DNA gyrase
DRB99_RS14750	COG0312	modulator of DNA gyrase
DRB99_RS14760	COG1595	DNA-templated transcription, initiation
DRB99_RS14790	COG3590	peptidase
DRB99_RS14840	COG2222	sugar isomerase
DRB99_RS14845	COG2188	Transcriptional regulator
DRB99_RS14850	COG3716	PTS system mannose fructose sorbose family IID component
DRB99_RS14855	COG3715	PTS system
DRB99_RS14860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS14870	COG2971	BadF BadG BcrA BcrD
DRB99_RS14875	COG1653	transport
DRB99_RS14880	COG5426	von Willebrand factor, type A
DRB99_RS14885	COG0395	ABC-type sugar transport system, permease component
DRB99_RS14890	COG1175	transmembrane transport
DRB99_RS14895	COG1917	Cupin 2, conserved barrel domain protein
DRB99_RS14895	COG2207	Transcriptional regulator
DRB99_RS15015	COG4166	transmembrane transport
DRB99_RS15045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DRB99_RS15055	COG1187	pseudouridine synthase activity
DRB99_RS15060	COG0741	lytic transglycosylase activity
DRB99_RS15070	COG1671	Belongs to the UPF0178 family
DRB99_RS15075	COG0166	Belongs to the GPI family
DRB99_RS15105	COG0517	IMP dehydrogenase activity
DRB99_RS15105	COG0516	GMP reductase activity
DRB99_RS15115	COG0459	protein refolding
DRB99_RS15120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DRB99_RS15140	COG1250	3-hydroxyacyl-CoA dehydrogenase
DRB99_RS15150	COG2086	electron transfer activity
DRB99_RS15155	COG1960	acyl-CoA dehydrogenase activity
DRB99_RS15160	COG1024	Enoyl-CoA hydratase
DRB99_RS15165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DRB99_RS15170	COG1971	Probably functions as a manganese efflux pump
DRB99_RS15175	COG2217	Heavy metal translocating P-type atpase
DRB99_RS15180	COG0640	Transcriptional regulator
DRB99_RS15190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS15200	COG2971	BadF BadG BcrA BcrD
DRB99_RS15205	COG1447	Phosphotransferase system cellobiose-specific component IIA
DRB99_RS15210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS15215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DRB99_RS15215	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DRB99_RS15225	COG2188	Transcriptional regulator
DRB99_RS15230	COG0662	Cupin 2, conserved barrel domain protein
DRB99_RS15230	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DRB99_RS15250	COG5002	protein histidine kinase activity
DRB99_RS15250	COG3850	Histidine kinase
DRB99_RS15255	COG0745	RESPONSE REGULATOR receiver
DRB99_RS15270	COG0653	protein targeting
DRB99_RS15275	COG0277	FAD linked oxidase domain protein
DRB99_RS15280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DRB99_RS15285	COG2086	electron transfer activity
DRB99_RS15290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DRB99_RS15300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DRB99_RS15310	COG0726	polysaccharide deacetylase
DRB99_RS15320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DRB99_RS15345	COG2873	o-acetylhomoserine
DRB99_RS15355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DRB99_RS15365	COG2116	formate transmembrane transporter activity
DRB99_RS15370	COG0366	Alpha amylase catalytic
DRB99_RS15375	COG2207	Transcriptional regulator
DRB99_RS15375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DRB99_RS15380	COG0058	SHG alpha-glucan phosphorylase activity
DRB99_RS15395	COG0616	signal peptide processing
DRB99_RS15400	COG0288	reversible hydration of carbon dioxide
DRB99_RS15410	COG1105	Belongs to the carbohydrate kinase PfkB family
DRB99_RS15425	COG0698	ribose 5-phosphate isomerase
DRB99_RS15430	COG3775	system Galactitol-specific IIC component
DRB99_RS15445	COG1349	DNA-binding transcription factor activity
DRB99_RS15485	COG1263	PTS System
DRB99_RS15485	COG2190	(PTS) system
DRB99_RS15485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS15490	COG0366	Alpha amylase catalytic
DRB99_RS15495	COG1609	Transcriptional regulator
DRB99_RS15525	COG0028	Belongs to the TPP enzyme family
DRB99_RS15535	COG0473	3-isopropylmalate dehydrogenase activity
DRB99_RS15540	COG0066	3-isopropylmalate dehydratase activity
DRB99_RS15545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DRB99_RS15550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DRB99_RS15555	COG0440	acetolactate synthase activity
DRB99_RS15565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DRB99_RS15570	COG4496	protein, YerC YecD
DRB99_RS15595	COG0534	Mate efflux family protein
DRB99_RS15600	COG0840	transmembrane signaling receptor activity
DRB99_RS15615	COG0280	phosphate acetyltransferase
DRB99_RS15620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DRB99_RS15630	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DRB99_RS15640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DRB99_RS15650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DRB99_RS15655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DRB99_RS15660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DRB99_RS15680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DRB99_RS15690	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DRB99_RS15690	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DRB99_RS15695	COG0860	N-Acetylmuramoyl-L-alanine amidase
DRB99_RS15700	COG1283	sodium-dependent phosphate transmembrane transporter activity
DRB99_RS15710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DRB99_RS15715	COG0101	tRNA pseudouridine synthase activity
DRB99_RS15720	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DRB99_RS15725	COG1122	ATPase activity
DRB99_RS15730	COG1122	ATPase activity
DRB99_RS15735	COG0203	ribosomal protein L17
DRB99_RS15740	COG0202	RNA polymerase activity
DRB99_RS15745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DRB99_RS15750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DRB99_RS15755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DRB99_RS15760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DRB99_RS15765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DRB99_RS15780	COG0563	adenylate kinase activity
DRB99_RS15785	COG0201	protein transport
DRB99_RS15790	COG0200	Binds to the 23S rRNA
DRB99_RS15795	COG1841	ribosomal large subunit assembly
DRB99_RS15805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DRB99_RS15810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DRB99_RS15815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DRB99_RS15825	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DRB99_RS15830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DRB99_RS15835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DRB99_RS15840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DRB99_RS15845	COG0255	Belongs to the universal ribosomal protein uL29 family
DRB99_RS15850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DRB99_RS15855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DRB99_RS15860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DRB99_RS15865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DRB99_RS15870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DRB99_RS15875	COG0089	rRNA binding
DRB99_RS15880	COG0088	Forms part of the polypeptide exit tunnel
DRB99_RS15885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DRB99_RS15890	COG0051	transcription antitermination factor activity, RNA binding
DRB99_RS15895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DRB99_RS15900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DRB99_RS15915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DRB99_RS15925	COG0222	ribosome binding
DRB99_RS15935	COG0081	regulation of translation
DRB99_RS15940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DRB99_RS15950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DRB99_RS15955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DRB99_RS15960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DRB99_RS15980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DRB99_RS15990	COG0215	cysteine-tRNA ligase activity
DRB99_RS15995	COG0442	prolyl-tRNA aminoacylation
DRB99_RS16000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DRB99_RS16005	COG4956	integral membrane protein (PIN domain superfamily)
DRB99_RS16015	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DRB99_RS16020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DRB99_RS16040	COG0542	response to heat
DRB99_RS16050	COG3880	PFAM UvrB UvrC protein
DRB99_RS16060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DRB99_RS16075	COG1774	PSP1 C-terminal conserved region
DRB99_RS16085	COG3870	Protein conserved in bacteria
DRB99_RS16090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DRB99_RS16150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DRB99_RS16155	COG0423	glycine-tRNA ligase activity
DRB99_RS16180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DRB99_RS16185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DRB99_RS16190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DRB99_RS16195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DRB99_RS16200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DRB99_RS16205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DRB99_RS16215	COG0037	tRNA processing
DRB99_RS16220	COG2208	phosphoserine phosphatase activity
DRB99_RS16275	COG1098	S1 RNA binding domain
DRB99_RS16295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DRB99_RS16305	COG3956	TIGRFAM MazG family protein
DRB99_RS16310	COG2244	polysaccharide biosynthetic process
DRB99_RS16315	COG2002	toxin-antitoxin pair type II binding
DRB99_RS16325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DRB99_RS16330	COG0193	aminoacyl-tRNA hydrolase activity
DRB99_RS16335	COG3850	Histidine kinase
DRB99_RS16335	COG5002	protein histidine kinase activity
DRB99_RS16340	COG0745	RESPONSE REGULATOR receiver
DRB99_RS16350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DRB99_RS16355	COG2088	sporulation resulting in formation of a cellular spore
DRB99_RS16360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DRB99_RS16365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DRB99_RS16390	COG2094	Belongs to the DNA glycosylase MPG family
DRB99_RS16400	COG0602	queuosine metabolic process
DRB99_RS16405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DRB99_RS16410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DRB99_RS16415	COG1328	CTP reductase activity
DRB99_RS16420	COG1307	EDD domain protein, DegV family
DRB99_RS16435	COG1141	Ferredoxin
DRB99_RS16470	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DRB99_RS16475	COG3584	3D domain protein
DRB99_RS16475	COG3583	domain protein
DRB99_RS16480	COG0084	hydrolase, TatD family'
DRB99_RS16485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DRB99_RS16500	COG1757	Na H antiporter
DRB99_RS16505	COG0006	proline dipeptidase activity
DRB99_RS16510	COG0700	Nucleoside recognition
DRB99_RS16515	COG2715	membrane protein required for spore maturation
DRB99_RS16525	COG0534	Mate efflux family protein
DRB99_RS16565	COG5002	protein histidine kinase activity
DRB99_RS16570	COG0745	RESPONSE REGULATOR receiver
DRB99_RS16590	COG2045	Belongs to the ComB family
DRB99_RS16595	COG1242	4 iron, 4 sulfur cluster binding
DRB99_RS16600	COG3949	Membrane
DRB99_RS16620	COG3583	domain protein
DRB99_RS16620	COG3584	3D domain protein
DRB99_RS16635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DRB99_RS16670	COG0840	transmembrane signaling receptor activity
DRB99_RS16670	COG3290	protein histidine kinase activity
DRB99_RS16680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DRB99_RS16710	COG0488	(ABC) transporter
DRB99_RS16715	COG0561	phosphatase activity
DRB99_RS16730	COG0688	phosphatidylethanolamine metabolic process
DRB99_RS16745	COG0784	Response regulator, receiver
DRB99_RS16745	COG2205	protein histidine kinase activity
DRB99_RS16760	COG1376	ErfK ybiS ycfS ynhG family protein
DRB99_RS16765	COG1074	ATP-dependent DNA helicase activity
DRB99_RS16770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DRB99_RS16800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DRB99_RS16815	COG1827	regulation of RNA biosynthetic process
DRB99_RS16845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DRB99_RS16850	COG0187	DNA topoisomerase II activity
DRB99_RS16860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DRB99_RS16870	COG0592	DNA-directed DNA polymerase activity
DRB99_RS16875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DRB99_RS16880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DRB99_RS16885	COG0594	ribonuclease P activity
DRB99_RS16890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DRB99_RS16900	COG1847	R3H domain protein
DRB99_RS16905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DRB99_RS16910	COG0445	tRNA wobble uridine modification
DRB99_RS16920	COG1475	DNA binding
DRB99_RS16925	COG1192	Involved in chromosome partitioning
DRB99_RS16930	COG1475	DNA binding
DRB99_RS16945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DRB99_RS16960	COG0668	transmembrane transport
DRB99_RS16970	COG0360	Binds together with S18 to 16S ribosomal RNA
DRB99_RS16980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DRB99_RS16990	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DRB99_RS16995	COG0359	binds to the 23S rRNA
DRB99_RS17000	COG0470	DNA polymerase III
DRB99_RS17000	COG1067	ATP-dependent peptidase activity
DRB99_RS17005	COG0305	Participates in initiation and elongation during chromosome replication
DRB99_RS17015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DRB99_RS17020	COG0281	malic enzyme
DRB99_RS17035	COG0385	Bile acid
DRB99_RS17045	COG2081	HI0933 family
DRB99_RS17110	COG1484	DNA-dependent DNA replication
DRB99_RS17120	COG1404	Belongs to the peptidase S8 family
DRB99_RS17150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DRB99_RS17155	COG0653	protein targeting
DRB99_RS17170	COG1392	Phosphate transport regulator
DRB99_RS17175	COG0306	phosphate transporter
DRB99_RS17180	COG2824	Alkylphosphonate utilization operon protein PhnA
DRB99_RS17205	COG1447	Phosphotransferase system cellobiose-specific component IIA
DRB99_RS17215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS17220	COG2188	Transcriptional regulator
DRB99_RS17225	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS17230	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DRB99_RS17235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DRB99_RS17250	COG0383	alpha-mannosidase activity
DRB99_RS17255	COG1917	Cupin 2, conserved barrel domain protein
DRB99_RS17255	COG2207	Transcriptional regulator
DRB99_RS17285	COG1737	Transcriptional regulator
DRB99_RS17290	COG3394	polysaccharide catabolic process
DRB99_RS17295	COG1263	PTS System
DRB99_RS17295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS17295	COG2190	(PTS) system
DRB99_RS17300	COG1486	melibiose metabolic process
DRB99_RS17310	COG2116	formate transmembrane transporter activity
DRB99_RS17315	COG1882	Formate acetyltransferase
DRB99_RS17320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DRB99_RS17340	COG0745	RESPONSE REGULATOR receiver
DRB99_RS17345	COG5002	protein histidine kinase activity
DRB99_RS17345	COG3850	Histidine kinase
DRB99_RS17350	COG0789	Transcriptional regulator
DRB99_RS17360	COG0583	DNA-binding transcription factor activity
DRB99_RS17365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DRB99_RS17370	COG3842	ATPase activity
DRB99_RS17375	COG1175	transmembrane transport
DRB99_RS17390	COG5566	PFAM Mor transcription activator
DRB99_RS17410	COG0561	phosphatase activity
DRB99_RS17420	COG2239	Acts as a magnesium transporter
DRB99_RS17435	COG3328	transposase activity
DRB99_RS17485	COG1132	(ABC) transporter
DRB99_RS17500	COG1247	-acetyltransferase
DRB99_RS17515	COG0583	DNA-binding transcription factor activity
DRB99_RS17520	COG0747	negative chemotaxis
DRB99_RS17525	COG0601	transmembrane transport
DRB99_RS17540	COG1124	(ABC) transporter
DRB99_RS17550	COG0534	Mate efflux family protein
DRB99_RS17560	COG1263	PTS System
DRB99_RS17560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS17570	COG2521	methyltransferase
DRB99_RS17570	COG2136	Putative SAM-dependent methyltransferase
DRB99_RS17590	COG2226	methyltransferase
DRB99_RS17595	COG1609	Transcriptional regulator
DRB99_RS17600	COG0534	Mate efflux family protein
DRB99_RS17605	COG2746	aminoglycoside 3-N-acetyltransferase activity
DRB99_RS17615	COG1346	cytolysis
DRB99_RS17625	COG2186	Transcriptional regulator
DRB99_RS17630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DRB99_RS17640	COG1116	anion transmembrane transporter activity
DRB99_RS17650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DRB99_RS17655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DRB99_RS17665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DRB99_RS17665	COG0167	dihydroorotate dehydrogenase activity
DRB99_RS17680	COG0159	tryptophan synthase activity
DRB99_RS17685	COG0583	DNA-binding transcription factor activity
DRB99_RS17710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DRB99_RS17720	COG1737	Transcriptional regulator
DRB99_RS17725	COG0363	glucosamine-6-phosphate deaminase activity
DRB99_RS17735	COG5002	protein histidine kinase activity
DRB99_RS17750	COG0515	serine threonine protein kinase
DRB99_RS17760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS17760	COG1263	PTS System
DRB99_RS17765	COG0366	Alpha amylase catalytic
DRB99_RS17770	COG2188	Transcriptional regulator
DRB99_RS17775	COG0426	domain, Protein
DRB99_RS17780	COG0586	Pfam SNARE associated Golgi protein
DRB99_RS17805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DRB99_RS17815	COG3706	GGDEF domain
DRB99_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
DRB99_RS17845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DRB99_RS17850	COG0789	Transcriptional regulator
DRB99_RS17900	COG1132	(ABC) transporter
DRB99_RS17905	COG1132	(ABC) transporter
DRB99_RS17940	COG0446	pyridine nucleotide-disulphide oxidoreductase
DRB99_RS17945	COG1283	sodium-dependent phosphate transmembrane transporter activity
DRB99_RS17955	COG2801	Transposase and inactivated derivatives
DRB99_RS17960	COG2508	Transcriptional regulator
DRB99_RS17970	COG3257	ureidoglycine aminohydrolase activity
DRB99_RS17975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DRB99_RS17995	COG4974	Belongs to the 'phage' integrase family
DRB99_RS18005	COG0346	lactoylglutathione lyase activity
DRB99_RS18020	COG3853	Toxic anion resistance protein (TelA)
DRB99_RS18030	COG0534	Mate efflux family protein
DRB99_RS18040	COG1151	hydroxylamine reductase activity
DRB99_RS18050	COG1335	isochorismatase
DRB99_RS18060	COG1733	regulation of RNA biosynthetic process
DRB99_RS18070	COG4187	Peptidase family M20/M25/M40
DRB99_RS18075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DRB99_RS18085	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DRB99_RS18105	COG5002	protein histidine kinase activity
DRB99_RS18115	COG3963	phosphatidate phosphatase activity
DRB99_RS18125	COG4989	oxidoreductase activity
DRB99_RS18130	COG1737	Transcriptional regulator
DRB99_RS18140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DRB99_RS18145	COG2971	BadF BadG BcrA BcrD
DRB99_RS18155	COG1447	Phosphotransferase system cellobiose-specific component IIA
DRB99_RS18160	COG1486	melibiose metabolic process
DRB99_RS18165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS18170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS18195	COG0789	Transcriptional regulator
DRB99_RS18235	COG1408	metallophosphoesterase
DRB99_RS18285	COG2203	Gaf domain
DRB99_RS18285	COG2199	diguanylate cyclase activity
DRB99_RS18315	COG4185	zeta toxin
DRB99_RS18335	COG1917	Cupin 2, conserved barrel domain protein
DRB99_RS18335	COG2169	Transcriptional regulator
DRB99_RS18350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DRB99_RS18375	COG2264	protein methyltransferase activity
DRB99_RS18380	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DRB99_RS18385	COG0371	Dehydrogenase
DRB99_RS18395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DRB99_RS18400	COG0583	DNA-binding transcription factor activity
DRB99_RS18405	COG0697	spore germination
DRB99_RS18430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DRB99_RS18445	COG0840	transmembrane signaling receptor activity
DRB99_RS18470	COG0656	L-ascorbic acid biosynthetic process
DRB99_RS18505	COG0534	Mate efflux family protein
DRB99_RS18515	COG0586	Pfam SNARE associated Golgi protein
DRB99_RS18555	COG5658	integral membrane protein
DRB99_RS18560	COG0640	Transcriptional regulator
DRB99_RS18565	COG1307	EDD domain protein, DegV family
DRB99_RS18570	COG1309	transcriptional regulator
DRB99_RS18575	COG0561	phosphatase activity
DRB99_RS18585	COG3716	PTS system mannose fructose sorbose family IID component
DRB99_RS18610	COG2197	response regulator
DRB99_RS18615	COG4585	Histidine kinase
DRB99_RS18640	COG0840	transmembrane signaling receptor activity
DRB99_RS18645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DRB99_RS18650	COG1126	abc transporter atp-binding protein
DRB99_RS18655	COG0765	amino acid transport
DRB99_RS18665	COG0778	Nitroreductase
DRB99_RS18670	COG1301	dicarboxylic acid transport
DRB99_RS18675	COG1910	domain protein
DRB99_RS18680	COG0725	ABC transporter, periplasmic molybdate-binding protein
DRB99_RS18685	COG4149	molybdate abc transporter
DRB99_RS18690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DRB99_RS18700	COG1447	Phosphotransferase system cellobiose-specific component IIA
DRB99_RS18705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DRB99_RS18715	COG2723	6-phospho-beta-galactosidase activity
DRB99_RS18720	COG1940	carbohydrate kinase activity
DRB99_RS18730	COG1609	Transcriptional regulator
DRB99_RS18745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DRB99_RS18760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DRB99_RS18765	COG0167	dihydroorotate dehydrogenase activity
DRB99_RS18770	COG0402	S-adenosylhomocysteine deaminase activity
DRB99_RS18785	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DRB99_RS18800	COG0402	S-adenosylhomocysteine deaminase activity
DRB99_RS18805	COG1132	(ABC) transporter
DRB99_RS18820	COG3842	ATPase activity
DRB99_RS18825	COG0395	ABC-type sugar transport system, permease component
DRB99_RS18830	COG1175	transmembrane transport
DRB99_RS18835	COG1653	transport
DRB99_RS18840	COG0561	phosphatase activity
DRB99_RS18845	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DRB99_RS18860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DRB99_RS18870	COG0840	transmembrane signaling receptor activity
DRB99_RS18875	COG3279	Response regulator of the LytR AlgR family
DRB99_RS18890	COG0745	RESPONSE REGULATOR receiver
DRB99_RS18900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DRB99_RS18905	COG3708	Transcriptional regulator
DRB99_RS18905	COG2207	Transcriptional regulator
DRB99_RS18915	COG0655	NAD(P)H dehydrogenase (quinone) activity
DRB99_RS18930	COG0546	phosphoglycolate phosphatase activity
DRB99_RS18940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DRB99_RS18965	COG2814	Major facilitator Superfamily
DRB99_RS18970	COG1566	PFAM secretion protein HlyD family protein
DRB99_RS18985	COG2801	Transposase and inactivated derivatives
DRB99_RS18990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DRB99_RS19005	COG0726	polysaccharide deacetylase
DRB99_RS19015	COG3647	Membrane
DRB99_RS19080	COG1335	isochorismatase
DRB99_RS19085	COG1733	regulation of RNA biosynthetic process
DRB99_RS19100	COG3279	Response regulator of the LytR AlgR family
DRB99_RS19110	COG1136	(ABC) transporter
DRB99_RS19115	COG3850	Histidine kinase
DRB99_RS19115	COG5002	protein histidine kinase activity
DRB99_RS19120	COG0745	RESPONSE REGULATOR receiver
DRB99_RS19135	COG1874	Beta-galactosidase
DRB99_RS19150	COG0395	ABC-type sugar transport system, permease component
DRB99_RS19155	COG4209	transmembrane transport
DRB99_RS19160	COG4753	response regulator
DRB99_RS19160	COG2207	Transcriptional regulator
DRB99_RS19165	COG2972	Histidine kinase
DRB99_RS19195	COG1120	ATPase activity
DRB99_RS19200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DRB99_RS19205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DRB99_RS19210	COG0534	Mate efflux family protein
DRB99_RS19215	COG0534	Mate efflux family protein
DRB99_RS19220	COG2207	Transcriptional regulator
DRB99_RS19220	COG1917	Cupin 2, conserved barrel domain protein
DRB99_RS19230	COG1737	Transcriptional regulator
DRB99_RS19235	COG1737	Transcriptional regulator
DRB99_RS19240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS19240	COG2190	(PTS) system
DRB99_RS19240	COG1263	PTS System
DRB99_RS19245	COG1486	melibiose metabolic process
DRB99_RS19265	COG1733	regulation of RNA biosynthetic process
DRB99_RS19280	COG1136	(ABC) transporter
DRB99_RS19290	COG2205	protein histidine kinase activity
DRB99_RS19295	COG0745	RESPONSE REGULATOR receiver
DRB99_RS19315	COG4302	ethanolamine ammonia-lyase activity
DRB99_RS19320	COG4303	Ethanolamine ammonia lyase large subunit
DRB99_RS19335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DRB99_RS19365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DRB99_RS19380	COG0673	inositol 2-dehydrogenase activity
DRB99_RS19385	COG0673	inositol 2-dehydrogenase activity
DRB99_RS19395	COG1122	ATPase activity
DRB99_RS19405	COG0310	cobalt ion transport
DRB99_RS19410	COG1606	tRNA processing
DRB99_RS19415	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DRB99_RS19420	COG1691	(AIR) carboxylase
DRB99_RS19440	COG5599	Phosphatase
DRB99_RS19445	COG1132	(ABC) transporter
DRB99_RS19450	COG1132	(ABC) transporter
DRB99_RS19470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DRB99_RS19485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DRB99_RS19495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DRB99_RS19505	COG1940	carbohydrate kinase activity
DRB99_RS19510	COG1070	Carbohydrate kinase
DRB99_RS19515	COG0039	L-malate dehydrogenase activity
DRB99_RS19565	COG5002	protein histidine kinase activity
DRB99_RS19570	COG0745	RESPONSE REGULATOR receiver
DRB99_RS19575	COG0243	molybdopterin cofactor binding
DRB99_RS19580	COG0745	RESPONSE REGULATOR receiver
DRB99_RS19585	COG5002	protein histidine kinase activity
DRB99_RS19595	COG0656	L-ascorbic acid biosynthetic process
DRB99_RS19600	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DRB99_RS19610	COG0840	transmembrane signaling receptor activity
DRB99_RS19635	COG1546	Belongs to the CinA family
DRB99_RS19635	COG1058	Belongs to the CinA family
DRB99_RS19645	COG1854	S-ribosylhomocysteine lyase activity
DRB99_RS19655	COG0701	Predicted permease
DRB99_RS19665	COG2033	superoxide reductase activity
DRB99_RS19675	COG2076	Multidrug Resistance protein
DRB99_RS19690	COG0583	DNA-binding transcription factor activity
DRB99_RS19695	COG0671	phosphoesterase, PA-phosphatase related
DRB99_RS19715	COG0386	Belongs to the glutathione peroxidase family
DRB99_RS19720	COG0386	Belongs to the glutathione peroxidase family
DRB99_RS19735	COG0310	cobalt ion transport
DRB99_RS19740	COG1122	ATPase activity
DRB99_RS19750	COG5002	protein histidine kinase activity
DRB99_RS19765	COG4974	Belongs to the 'phage' integrase family
DRB99_RS19775	COG1192	Involved in chromosome partitioning
DRB99_RS19795	COG0786	glutamate:sodium symporter activity
DRB99_RS19800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DRB99_RS19805	COG1357	PFAM Pentapeptide repeats (8 copies)
DRB99_RS19825	COG1122	ATPase activity
DRB99_RS19850	COG3158	transport of potassium into the cell
DRB99_RS19855	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DRB99_RS19860	COG0667	Aldo Keto reductase
DRB99_RS19870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DRB99_RS19875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DRB99_RS19880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DRB99_RS19885	COG1120	ATPase activity
DRB99_RS19895	COG0789	Transcriptional regulator
DRB99_RS19895	COG4978	Transcriptional regulator
DRB99_RS19905	COG1132	(ABC) transporter
DRB99_RS19920	COG2233	PERMEase
DRB99_RS19925	COG0277	FAD linked oxidase domain protein
DRB99_RS19930	COG1028	Short-chain dehydrogenase reductase Sdr
DRB99_RS19935	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DRB99_RS19940	COG1737	Transcriptional regulator
DRB99_RS19945	COG2197	response regulator
DRB99_RS19985	COG3715	PTS system
DRB99_RS19990	COG3716	PTS system mannose fructose sorbose family IID component
DRB99_RS20010	COG5002	protein histidine kinase activity
DRB99_RS20010	COG3850	Histidine kinase
DRB99_RS20015	COG0697	spore germination
DRB99_RS20020	COG2207	Transcriptional regulator
DRB99_RS20020	COG1917	Cupin 2, conserved barrel domain protein
DRB99_RS20025	COG0840	transmembrane signaling receptor activity
DRB99_RS20065	COG1172	Belongs to the binding-protein-dependent transport system permease family
DRB99_RS20070	COG1879	ABC-type sugar transport system periplasmic component
DRB99_RS20080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DRB99_RS20085	COG1609	Transcriptional regulator
DRB99_RS20095	COG1328	CTP reductase activity
DRB99_RS20105	COG5002	protein histidine kinase activity
DRB99_RS20110	COG1342	Belongs to the UPF0251 family
DRB99_RS20125	COG4209	transmembrane transport
DRB99_RS20130	COG0395	ABC-type sugar transport system, permease component
DRB99_RS20140	COG2207	Transcriptional regulator
DRB99_RS20140	COG1917	Cupin 2, conserved barrel domain protein
DRB99_RS20145	COG1501	Belongs to the glycosyl hydrolase 31 family
DRB99_RS20150	COG1472	Belongs to the glycosyl hydrolase 3 family
DRB99_RS20165	COG0840	transmembrane signaling receptor activity
DRB99_RS20175	COG1028	Short-chain dehydrogenase reductase Sdr
DRB99_RS20180	COG0242	peptide deformylase activity
DRB99_RS20185	COG4555	ABC transporter
DRB99_RS20205	COG1966	Carbon starvation protein
DRB99_RS20220	COG1216	Glycosyl transferase, family 2
DRB99_RS20225	COG2207	Transcriptional regulator
DRB99_RS20230	COG1132	(ABC) transporter
DRB99_RS20235	COG1132	(ABC) transporter
DRB99_RS20255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DRB99_RS20260	COG2972	Histidine kinase
DRB99_RS20265	COG2207	Transcriptional regulator
DRB99_RS20265	COG4753	response regulator
DRB99_RS20280	COG0366	Alpha amylase catalytic
DRB99_RS20315	COG0148	phosphopyruvate hydratase activity
DRB99_RS20325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DRB99_RS20330	COG4149	molybdate abc transporter
DRB99_RS20335	COG0725	ABC transporter, periplasmic molybdate-binding protein
DRB99_RS20350	COG1910	domain protein
DRB99_RS20365	COG0347	Belongs to the P(II) protein family
DRB99_RS20385	COG1433	Dinitrogenase iron-molybdenum cofactor
DRB99_RS20385	COG0535	radical SAM domain protein
DRB99_RS20390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DRB99_RS20410	COG2814	Major facilitator Superfamily
DRB99_RS20415	COG2207	Transcriptional regulator
DRB99_RS20415	COG1609	Transcriptional regulator
DRB99_RS20425	COG2376	Dihydroxyacetone kinase
DRB99_RS20435	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DRB99_RS20440	COG3275	phosphorelay sensor kinase activity
DRB99_RS20445	COG2207	Transcriptional regulator
DRB99_RS20450	COG1882	Formate acetyltransferase
DRB99_RS20480	COG1263	PTS System
DRB99_RS20480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DRB99_RS20480	COG2190	(PTS) system
DRB99_RS20490	COG0583	DNA-binding transcription factor activity
DRB99_RS20495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DRB99_RS20500	COG0163	prenyltransferase activity
DRB99_RS20530	COG1349	DNA-binding transcription factor activity
DRB99_RS20535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DRB99_RS20540	COG1882	Formate acetyltransferase
DRB99_RS20550	COG1737	Transcriptional regulator