locus-tag	class	description
HZF06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZF06_RS00010	COG0592	DNA-directed DNA polymerase activity
HZF06_RS00015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZF06_RS00030	COG0187	DNA topoisomerase II activity
HZF06_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZF06_RS00070	COG1827	regulation of RNA biosynthetic process
HZF06_RS00095	COG4585	Histidine kinase
HZF06_RS00100	COG2197	response regulator
HZF06_RS00105	COG1131	(ABC) transporter
HZF06_RS00130	COG2267	carboxylic ester hydrolase activity
HZF06_RS00150	COG1263	PTS System
HZF06_RS00150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS00155	COG0366	Alpha amylase catalytic
HZF06_RS00160	COG2188	Transcriptional regulator
HZF06_RS00165	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HZF06_RS00170	COG1074	ATP-dependent DNA helicase activity
HZF06_RS00175	COG0617	tRNA 3'-terminal CCA addition
HZF06_RS00180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZF06_RS00180	COG0723	plastoquinol--plastocyanin reductase activity
HZF06_RS00185	COG1376	ErfK ybiS ycfS ynhG family protein
HZF06_RS00200	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZF06_RS00215	COG0419	ATPase involved in DNA repair
HZF06_RS00225	COG5002	protein histidine kinase activity
HZF06_RS00240	COG1215	transferase activity, transferring glycosyl groups
HZF06_RS00265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZF06_RS00280	COG0688	phosphatidylethanolamine metabolic process
HZF06_RS00290	COG1511	domain protein
HZF06_RS00310	COG0463	Glycosyl transferase, family 2
HZF06_RS00310	COG0457	Tetratricopeptide repeat
HZF06_RS00315	COG0438	transferase activity, transferring glycosyl groups
HZF06_RS00315	COG1216	Glycosyl transferase, family 2
HZF06_RS00340	COG1136	(ABC) transporter
HZF06_RS00340	COG0577	efflux transmembrane transporter activity
HZF06_RS00345	COG0577	efflux transmembrane transporter activity
HZF06_RS00395	COG2814	Major facilitator Superfamily
HZF06_RS00405	COG0534	Mate efflux family protein
HZF06_RS00410	COG4536	flavin adenine dinucleotide binding
HZF06_RS00415	COG0590	tRNA wobble adenosine to inosine editing
HZF06_RS00425	COG0460	homoserine dehydrogenase
HZF06_RS00455	COG0701	Predicted permease
HZF06_RS00465	COG3290	protein histidine kinase activity
HZF06_RS00475	COG1053	succinate dehydrogenase
HZF06_RS00480	COG3976	FMN-binding domain protein
HZF06_RS00480	COG1053	succinate dehydrogenase
HZF06_RS00480	COG0431	NADPH-dependent FMN reductase
HZF06_RS00505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZF06_RS00515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZF06_RS00525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZF06_RS00530	COG2873	o-acetylhomoserine
HZF06_RS00535	COG0529	Catalyzes the synthesis of activated sulfate
HZF06_RS00540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZF06_RS00545	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZF06_RS00545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZF06_RS00545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZF06_RS00545	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZF06_RS00550	COG4521	taurine ABC transporter
HZF06_RS00555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZF06_RS00560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZF06_RS00565	COG0175	sulfate reduction
HZF06_RS00570	COG0529	Catalyzes the synthesis of activated sulfate
HZF06_RS00570	COG2895	sulfate adenylyltransferase (ATP) activity
HZF06_RS00575	COG5002	protein histidine kinase activity
HZF06_RS00585	COG1876	peptidase activity
HZF06_RS00610	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZF06_RS00615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZF06_RS00620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZF06_RS00635	COG4974	Belongs to the 'phage' integrase family
HZF06_RS00655	COG0004	ammonium transporteR
HZF06_RS00665	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HZF06_RS00675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZF06_RS00680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZF06_RS00700	COG5002	protein histidine kinase activity
HZF06_RS00710	COG0701	Predicted permease
HZF06_RS00730	COG0640	Transcriptional regulator
HZF06_RS00755	COG0791	NLP P60 protein
HZF06_RS00760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZF06_RS00765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZF06_RS00785	COG1428	Deoxynucleoside kinase
HZF06_RS00795	COG3655	Transcriptional regulator
HZF06_RS00835	COG0668	transmembrane transport
HZF06_RS00845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZF06_RS00870	COG3711	transcriptional antiterminator
HZF06_RS00875	COG2190	(PTS) system
HZF06_RS00880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS00880	COG1263	PTS System
HZF06_RS00880	COG2190	(PTS) system
HZF06_RS00885	COG0367	asparagine synthase
HZF06_RS00890	COG1959	2 iron, 2 sulfur cluster binding
HZF06_RS00905	COG2270	Major facilitator Superfamily
HZF06_RS00915	COG0840	transmembrane signaling receptor activity
HZF06_RS00920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZF06_RS00955	COG2205	protein histidine kinase activity
HZF06_RS00960	COG0745	RESPONSE REGULATOR receiver
HZF06_RS00965	COG1132	(ABC) transporter
HZF06_RS00970	COG1132	(ABC) transporter
HZF06_RS00975	COG0561	phosphatase activity
HZF06_RS00990	COG0067	glutamate synthase
HZF06_RS00990	COG0069	glutamate synthase activity
HZF06_RS00990	COG0070	glutamate synthase
HZF06_RS00995	COG0493	'glutamate synthase
HZF06_RS01005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZF06_RS01015	COG0386	Belongs to the glutathione peroxidase family
HZF06_RS01020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZF06_RS01110	COG0058	SHG alpha-glucan phosphorylase activity
HZF06_RS01115	COG0366	Alpha amylase catalytic
HZF06_RS01115	COG3103	Sh3 type 3 domain protein
HZF06_RS01135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZF06_RS01140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZF06_RS01155	COG2188	Transcriptional regulator
HZF06_RS01160	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS01165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS01170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS01175	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS01210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZF06_RS01235	COG1349	DNA-binding transcription factor activity
HZF06_RS01245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS01245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS01245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS01260	COG0017	Asparaginyl-tRNA synthetase
HZF06_RS01270	COG1063	alcohol dehydrogenase
HZF06_RS01275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZF06_RS01285	COG1940	carbohydrate kinase activity
HZF06_RS01305	COG1058	Belongs to the CinA family
HZF06_RS01305	COG1546	Belongs to the CinA family
HZF06_RS01315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZF06_RS01320	COG0436	Aminotransferase
HZF06_RS01325	COG1268	BioY protein
HZF06_RS01335	COG0488	(ABC) transporter
HZF06_RS01385	COG1131	(ABC) transporter
HZF06_RS01395	COG1032	radical SAM domain protein
HZF06_RS01420	COG1733	regulation of RNA biosynthetic process
HZF06_RS01425	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZF06_RS01455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZF06_RS01480	COG3708	Transcriptional regulator
HZF06_RS01480	COG2207	Transcriptional regulator
HZF06_RS01495	COG0534	Mate efflux family protein
HZF06_RS01525	COG0778	Nitroreductase
HZF06_RS01545	COG0277	FAD linked oxidase domain protein
HZF06_RS01550	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS01580	COG2362	D-Aminopeptidase
HZF06_RS01595	COG2364	Membrane
HZF06_RS01600	COG1876	peptidase activity
HZF06_RS01605	COG4632	Exopolysaccharide biosynthesis protein
HZF06_RS01605	COG5434	Belongs to the glycosyl hydrolase 28 family
HZF06_RS01615	COG5002	protein histidine kinase activity
HZF06_RS01625	COG0745	RESPONSE REGULATOR receiver
HZF06_RS01630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HZF06_RS01650	COG1349	DNA-binding transcription factor activity
HZF06_RS01655	COG3959	Transketolase, thiamine diphosphate binding domain
HZF06_RS01660	COG3958	Transketolase
HZF06_RS01665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZF06_RS01670	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS01670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS01675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS01685	COG3775	system Galactitol-specific IIC component
HZF06_RS01690	COG1141	Ferredoxin
HZF06_RS01695	COG1063	alcohol dehydrogenase
HZF06_RS01700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZF06_RS01705	COG0698	ribose 5-phosphate isomerase
HZF06_RS01725	COG1253	flavin adenine dinucleotide binding
HZF06_RS01755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZF06_RS01770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZF06_RS01780	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZF06_RS01800	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HZF06_RS01805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZF06_RS01810	COG2002	toxin-antitoxin pair type II binding
HZF06_RS01820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS01820	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS01825	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS01825	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS01830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS01830	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS01835	COG3715	PTS system
HZF06_RS01840	COG3716	PTS system mannose fructose sorbose family IID component
HZF06_RS01845	COG2132	Multicopper oxidase
HZF06_RS01850	COG0745	RESPONSE REGULATOR receiver
HZF06_RS01855	COG2205	protein histidine kinase activity
HZF06_RS01855	COG2770	Histidine kinase
HZF06_RS01860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZF06_RS01865	COG0840	transmembrane signaling receptor activity
HZF06_RS01875	COG1136	(ABC) transporter
HZF06_RS01880	COG0577	efflux transmembrane transporter activity
HZF06_RS01880	COG1136	(ABC) transporter
HZF06_RS01885	COG1199	ATP-dependent helicase activity
HZF06_RS01900	COG0840	transmembrane signaling receptor activity
HZF06_RS01915	COG2235	arginine
HZF06_RS02015	COG0534	Mate efflux family protein
HZF06_RS02055	COG1363	Peptidase, m42
HZF06_RS02060	COG2080	2 iron, 2 sulfur cluster binding
HZF06_RS02060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZF06_RS02105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZF06_RS02110	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HZF06_RS02115	COG1924	4 iron, 4 sulfur cluster binding
HZF06_RS02120	COG0709	Synthesizes selenophosphate from selenide and ATP
HZF06_RS02125	COG0425	Belongs to the sulfur carrier protein TusA family
HZF06_RS02135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZF06_RS02145	COG3608	succinylglutamate desuccinylase aspartoacylase
HZF06_RS02145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZF06_RS02150	COG3608	succinylglutamate desuccinylase aspartoacylase
HZF06_RS02150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZF06_RS02155	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZF06_RS02160	COG1058	Belongs to the CinA family
HZF06_RS02160	COG1546	Belongs to the CinA family
HZF06_RS02165	COG0315	cyclic pyranopterin monophosphate synthase activity
HZF06_RS02175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZF06_RS02180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZF06_RS02205	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HZF06_RS02210	COG0402	S-adenosylhomocysteine deaminase activity
HZF06_RS02230	COG0251	oxidation-reduction process
HZF06_RS02240	COG1335	isochorismatase
HZF06_RS02260	COG0427	acetyl-CoA hydrolase
HZF06_RS02275	COG4377	Putative membrane peptidase family (DUF2324)
HZF06_RS02280	COG1309	transcriptional regulator
HZF06_RS02285	COG1131	(ABC) transporter
HZF06_RS02290	COG0842	Transport permease protein
HZF06_RS02290	COG1511	domain protein
HZF06_RS02305	COG3459	Glycosyltransferase 36 associated
HZF06_RS02315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS02320	COG0765	amino acid transport
HZF06_RS02325	COG1126	abc transporter atp-binding protein
HZF06_RS02330	COG3842	ATPase activity
HZF06_RS02335	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZF06_RS02340	COG1177	transmembrane transport
HZF06_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
HZF06_RS02360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZF06_RS02380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZF06_RS02390	COG1295	ribonuclease BN
HZF06_RS02400	COG0426	domain, Protein
HZF06_RS02410	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS02410	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS02420	COG3414	Phosphotransferase system galactitol-specific IIB component
HZF06_RS02425	COG3775	system Galactitol-specific IIC component
HZF06_RS02430	COG1063	alcohol dehydrogenase
HZF06_RS02440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZF06_RS02445	COG0698	ribose 5-phosphate isomerase
HZF06_RS02455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZF06_RS02470	COG0736	holo-[acyl-carrier-protein] synthase activity
HZF06_RS02475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZF06_RS02475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZF06_RS02495	COG2337	Toxic component of a toxin-antitoxin (TA) module
HZF06_RS02500	COG3959	Transketolase, thiamine diphosphate binding domain
HZF06_RS02505	COG3958	Transketolase
HZF06_RS02515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZF06_RS02520	COG2884	Cell division ATP-binding protein ftsE
HZF06_RS02525	COG2177	Part of the ABC transporter FtsEX involved in
HZF06_RS02530	COG0793	Belongs to the peptidase S41A family
HZF06_RS02530	COG3409	Peptidoglycan-binding domain 1 protein
HZF06_RS02540	COG0556	nucleotide-excision repair
HZF06_RS02545	COG1737	Transcriptional regulator
HZF06_RS02555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS02560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS02565	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS02575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZF06_RS02595	COG1716	ATPase activity
HZF06_RS02605	COG0768	penicillin binding
HZF06_RS02630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZF06_RS02635	COG1481	regulation of sporulation
HZF06_RS02640	COG0840	transmembrane signaling receptor activity
HZF06_RS02655	COG0469	pyruvate kinase activity
HZF06_RS02660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZF06_RS02665	COG1910	domain protein
HZF06_RS02675	COG0347	Belongs to the P(II) protein family
HZF06_RS02680	COG0347	Belongs to the P(II) protein family
HZF06_RS02700	COG0535	radical SAM domain protein
HZF06_RS02700	COG1433	Dinitrogenase iron-molybdenum cofactor
HZF06_RS02720	COG3711	transcriptional antiterminator
HZF06_RS02725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS02725	COG2213	PTS system mannitol-specific
HZF06_RS02730	COG0246	Mannitol dehydrogenase
HZF06_RS02750	COG5002	protein histidine kinase activity
HZF06_RS02755	COG0745	RESPONSE REGULATOR receiver
HZF06_RS02800	COG1733	regulation of RNA biosynthetic process
HZF06_RS02815	COG1309	transcriptional regulator
HZF06_RS02825	COG0596	Alpha beta hydrolase
HZF06_RS02845	COG3850	Histidine kinase
HZF06_RS02845	COG5002	protein histidine kinase activity
HZF06_RS02850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZF06_RS02865	COG2207	Transcriptional regulator
HZF06_RS02885	COG0708	Exodeoxyribonuclease III
HZF06_RS02890	COG0384	phenazine biosynthesis protein PhzF
HZF06_RS02915	COG0601	transmembrane transport
HZF06_RS02920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZF06_RS02925	COG0444	Belongs to the ABC transporter superfamily
HZF06_RS02930	COG4608	Belongs to the ABC transporter superfamily
HZF06_RS02950	COG1175	transmembrane transport
HZF06_RS02955	COG0395	ABC-type sugar transport system, permease component
HZF06_RS02960	COG1554	hydrolase, family 65, central catalytic
HZF06_RS02965	COG1554	hydrolase, family 65, central catalytic
HZF06_RS02970	COG1609	Transcriptional regulator
HZF06_RS02975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZF06_RS02980	COG3842	ATPase activity
HZF06_RS03015	COG0519	Catalyzes the synthesis of GMP from XMP
HZF06_RS03015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZF06_RS03025	COG0431	NADPH-dependent FMN reductase
HZF06_RS03025	COG1053	succinate dehydrogenase
HZF06_RS03025	COG3976	FMN-binding domain protein
HZF06_RS03030	COG0583	DNA-binding transcription factor activity
HZF06_RS03045	COG0066	3-isopropylmalate dehydratase activity
HZF06_RS03050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZF06_RS03055	COG0583	DNA-binding transcription factor activity
HZF06_RS03065	COG3706	GGDEF domain
HZF06_RS03070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZF06_RS03075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZF06_RS03085	COG1733	regulation of RNA biosynthetic process
HZF06_RS03090	COG0840	transmembrane signaling receptor activity
HZF06_RS03110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS03120	COG1126	abc transporter atp-binding protein
HZF06_RS03125	COG1511	domain protein
HZF06_RS03130	COG3180	Ammonia monooxygenase
HZF06_RS03140	COG1846	Transcriptional regulator
HZF06_RS03145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZF06_RS03160	COG0583	DNA-binding transcription factor activity
HZF06_RS03175	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZF06_RS03185	COG1151	hydroxylamine reductase activity
HZF06_RS03195	COG0765	amino acid transport
HZF06_RS03200	COG0765	amino acid transport
HZF06_RS03205	COG1126	abc transporter atp-binding protein
HZF06_RS03210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS03225	COG0697	spore germination
HZF06_RS03235	COG1733	regulation of RNA biosynthetic process
HZF06_RS03240	COG1454	alcohol dehydrogenase
HZF06_RS03245	COG0667	Aldo Keto reductase
HZF06_RS03250	COG0310	cobalt ion transport
HZF06_RS03260	COG1122	ATPase activity
HZF06_RS03265	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HZF06_RS03270	COG1691	(AIR) carboxylase
HZF06_RS03275	COG1606	tRNA processing
HZF06_RS03280	COG3290	protein histidine kinase activity
HZF06_RS03290	COG5002	protein histidine kinase activity
HZF06_RS03310	COG0442	prolyl-tRNA aminoacylation
HZF06_RS03335	COG3437	response regulator, receiver
HZF06_RS03345	COG1136	(ABC) transporter
HZF06_RS03350	COG0577	efflux transmembrane transporter activity
HZF06_RS03360	COG0745	RESPONSE REGULATOR receiver
HZF06_RS03365	COG2271	Major facilitator Superfamily
HZF06_RS03375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS03375	COG1263	PTS System
HZF06_RS03400	COG0129	dihydroxy-acid dehydratase activity
HZF06_RS03420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS03420	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS03425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS03430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS03435	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS03440	COG1472	Belongs to the glycosyl hydrolase 3 family
HZF06_RS03445	COG2059	Chromate
HZF06_RS03455	COG0583	DNA-binding transcription factor activity
HZF06_RS03460	COG1307	EDD domain protein, DegV family
HZF06_RS03465	COG0561	phosphatase activity
HZF06_RS03470	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS03475	COG2188	Transcriptional regulator
HZF06_RS03480	COG4948	Mandelate Racemase Muconate Lactonizing
HZF06_RS03485	COG1263	PTS System
HZF06_RS03485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS03485	COG2190	(PTS) system
HZF06_RS03490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZF06_RS03500	COG5001	Diguanylate cyclase
HZF06_RS03500	COG3300	MHYT domain
HZF06_RS03505	COG0406	alpha-ribazole phosphatase activity
HZF06_RS03535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZF06_RS03540	COG2207	Transcriptional regulator
HZF06_RS03540	COG1609	Transcriptional regulator
HZF06_RS03545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZF06_RS03550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZF06_RS03555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZF06_RS03560	COG1120	ATPase activity
HZF06_RS03565	COG1132	(ABC) transporter
HZF06_RS03575	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS03575	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS03580	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS03585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS03590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS03595	COG3250	beta-galactosidase activity
HZF06_RS03600	COG5566	PFAM Mor transcription activator
HZF06_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS03630	COG1312	Catalyzes the dehydration of D-mannonate
HZF06_RS03635	COG1904	glucuronate isomerase
HZF06_RS03650	COG0800	Aldolase
HZF06_RS03655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZF06_RS03685	COG2188	Transcriptional regulator
HZF06_RS03705	COG0673	inositol 2-dehydrogenase activity
HZF06_RS03710	COG0656	L-ascorbic acid biosynthetic process
HZF06_RS03725	COG1486	melibiose metabolic process
HZF06_RS03735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZF06_RS03740	COG0561	phosphatase activity
HZF06_RS03760	COG1854	S-ribosylhomocysteine lyase activity
HZF06_RS03765	COG4658	electron transport chain
HZF06_RS03770	COG4659	FMN binding
HZF06_RS03775	COG4660	Part of a membrane complex involved in electron transport
HZF06_RS03780	COG4657	Part of a membrane complex involved in electron transport
HZF06_RS03785	COG2878	Part of a membrane complex involved in electron transport
HZF06_RS03785	COG1245	4Fe-4S binding domain
HZF06_RS03810	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZF06_RS03815	COG1959	2 iron, 2 sulfur cluster binding
HZF06_RS03820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZF06_RS03825	COG2910	NAD(P)H-binding
HZF06_RS03830	COG0110	maltose O-acetyltransferase activity
HZF06_RS03835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS03845	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS03855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS03870	COG1132	(ABC) transporter
HZF06_RS03875	COG1132	(ABC) transporter
HZF06_RS03885	COG4509	Sortase family
HZF06_RS03910	COG3546	catalase activity
HZF06_RS03920	COG1794	racemase activity, acting on amino acids and derivatives
HZF06_RS03955	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS03970	COG0110	maltose O-acetyltransferase activity
HZF06_RS03975	COG1940	carbohydrate kinase activity
HZF06_RS03990	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS03995	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HZF06_RS04000	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS04025	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS04025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS04030	COG3715	PTS system
HZF06_RS04035	COG3716	PTS system mannose fructose sorbose family IID component
HZF06_RS04040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZF06_RS04045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HZF06_RS04045	COG0517	IMP dehydrogenase activity
HZF06_RS04050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS04050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS04055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZF06_RS04060	COG2508	Transcriptional regulator
HZF06_RS04065	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS04070	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZF06_RS04075	COG0154	amidase activity
HZF06_RS04080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZF06_RS04085	COG0017	Asparaginyl-tRNA synthetase
HZF06_RS04100	COG0824	Thioesterase
HZF06_RS04105	COG0840	transmembrane signaling receptor activity
HZF06_RS04110	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HZF06_RS04110	COG0778	Nitroreductase
HZF06_RS04120	COG1136	(ABC) transporter
HZF06_RS04125	COG0673	inositol 2-dehydrogenase activity
HZF06_RS04130	COG0514	ATP-dependent DNA helicase (RecQ)
HZF06_RS04135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZF06_RS04140	COG4585	Histidine kinase
HZF06_RS04145	COG2197	response regulator
HZF06_RS04155	COG1136	(ABC) transporter
HZF06_RS04165	COG1737	Transcriptional regulator
HZF06_RS04175	COG1115	amino acid carrier protein
HZF06_RS04190	COG3290	protein histidine kinase activity
HZF06_RS04205	COG3706	GGDEF domain
HZF06_RS04210	COG0579	oxidoreductase
HZF06_RS04215	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZF06_RS04225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HZF06_RS04235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZF06_RS04250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZF06_RS04260	COG1914	H( )-stimulated, divalent metal cation uptake system
HZF06_RS04265	COG1725	Transcriptional regulator
HZF06_RS04270	COG1131	(ABC) transporter
HZF06_RS04280	COG0561	phosphatase activity
HZF06_RS04300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZF06_RS04315	COG1187	pseudouridine synthase activity
HZF06_RS04370	COG2816	NAD+ diphosphatase activity
HZF06_RS04390	COG0019	diaminopimelate decarboxylase activity
HZF06_RS04400	COG0681	Belongs to the peptidase S26 family
HZF06_RS04405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZF06_RS04410	COG3973	AAA domain
HZF06_RS04415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS04420	COG0765	amino acid transport
HZF06_RS04435	COG1368	sulfuric ester hydrolase activity
HZF06_RS04440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZF06_RS04450	COG1362	aminopeptidase activity
HZF06_RS04460	COG2033	superoxide reductase activity
HZF06_RS04465	COG0745	RESPONSE REGULATOR receiver
HZF06_RS04470	COG5002	protein histidine kinase activity
HZF06_RS04475	COG0577	efflux transmembrane transporter activity
HZF06_RS04480	COG1136	(ABC) transporter
HZF06_RS04485	COG0561	phosphatase activity
HZF06_RS04495	COG1132	(ABC) transporter
HZF06_RS04500	COG1132	(ABC) transporter
HZF06_RS04505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZF06_RS04510	COG0561	phosphatase activity
HZF06_RS04515	COG0561	phosphatase activity
HZF06_RS04520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZF06_RS04525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZF06_RS04530	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HZF06_RS04535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HZF06_RS04540	COG0406	alpha-ribazole phosphatase activity
HZF06_RS04545	COG1492	cobalamin metabolic process
HZF06_RS04555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZF06_RS04560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZF06_RS04565	COG3842	ATPase activity
HZF06_RS04570	COG0561	phosphatase activity
HZF06_RS04575	COG1316	TRANSCRIPTIONal
HZF06_RS04580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZF06_RS04600	COG0697	spore germination
HZF06_RS04650	COG2357	RelA SpoT domain protein
HZF06_RS04685	COG0710	3-dehydroquinate dehydratase activity
HZF06_RS04715	COG1773	rubredoxin
HZF06_RS04715	COG1592	Rubrerythrin
HZF06_RS04720	COG0640	Transcriptional regulator
HZF06_RS04725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZF06_RS04735	COG4512	PFAM Accessory gene regulator B
HZF06_RS04750	COG3279	Response regulator of the LytR AlgR family
HZF06_RS04755	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZF06_RS04765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZF06_RS04770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZF06_RS04775	COG1605	Chorismate mutase
HZF06_RS04775	COG0077	Prephenate dehydratase
HZF06_RS04780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZF06_RS04790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZF06_RS04810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZF06_RS04815	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HZF06_RS04830	COG1609	Transcriptional regulator
HZF06_RS04880	COG4211	Belongs to the binding-protein-dependent transport system permease family
HZF06_RS04885	COG4753	response regulator
HZF06_RS04885	COG2207	Transcriptional regulator
HZF06_RS04890	COG2972	Histidine kinase
HZF06_RS04900	COG1879	ABC-type sugar transport system periplasmic component
HZF06_RS04905	COG1879	ABC-type sugar transport system periplasmic component
HZF06_RS04910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZF06_RS04915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZF06_RS04920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZF06_RS04925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZF06_RS04930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZF06_RS04935	COG0165	Argininosuccinate lyase
HZF06_RS04955	COG0191	fructose-bisphosphate aldolase activity
HZF06_RS04965	COG2323	membrane
HZF06_RS04970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZF06_RS04975	COG1760	l-serine dehydratase
HZF06_RS04980	COG1760	l-serine dehydratase
HZF06_RS04995	COG0351	phosphomethylpyrimidine kinase
HZF06_RS05005	COG0514	ATP-dependent DNA helicase (RecQ)
HZF06_RS05015	COG2084	Dehydrogenase
HZF06_RS05020	COG2766	serine protein kinase
HZF06_RS05025	COG2718	Belongs to the UPF0229 family
HZF06_RS05030	COG2719	SpoVR family
HZF06_RS05045	COG1183	phosphatidylcholine synthase activity
HZF06_RS05050	COG1597	lipid kinase activity
HZF06_RS05065	COG2239	Acts as a magnesium transporter
HZF06_RS05070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZF06_RS05080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZF06_RS05110	COG2720	vancomycin resistance protein
HZF06_RS05115	COG0561	phosphatase activity
HZF06_RS05120	COG1533	DNA photolyase activity
HZF06_RS05130	COG1307	EDD domain protein, DegV family
HZF06_RS05135	COG1744	ABC transporter substrate-binding protein PnrA-like
HZF06_RS05140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZF06_RS05155	COG0126	phosphoglycerate kinase activity
HZF06_RS05165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZF06_RS05230	COG3830	Belongs to the UPF0237 family
HZF06_RS05245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZF06_RS05255	COG1215	transferase activity, transferring glycosyl groups
HZF06_RS05260	COG0187	DNA topoisomerase II activity
HZF06_RS05265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZF06_RS05270	COG0693	protein deglycase activity
HZF06_RS05275	COG0612	Peptidase, M16
HZF06_RS05280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZF06_RS05280	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZF06_RS05290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZF06_RS05305	COG1392	Phosphate transport regulator
HZF06_RS05310	COG0306	phosphate transporter
HZF06_RS05325	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZF06_RS05365	COG3708	Transcriptional regulator
HZF06_RS05365	COG2207	Transcriptional regulator
HZF06_RS05375	COG1595	DNA-templated transcription, initiation
HZF06_RS05385	COG0626	cystathionine gamma-synthase activity
HZF06_RS05390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZF06_RS05395	COG0840	transmembrane signaling receptor activity
HZF06_RS05420	COG1131	(ABC) transporter
HZF06_RS05435	COG0714	Associated with various cellular activities
HZF06_RS05455	COG0840	transmembrane signaling receptor activity
HZF06_RS05465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZF06_RS05470	COG2340	Cysteine-rich secretory protein family
HZF06_RS05480	COG1329	Transcriptional regulator
HZF06_RS05515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZF06_RS05520	COG1956	GAF domain-containing protein
HZF06_RS05535	COG0534	Mate efflux family protein
HZF06_RS05580	COG0756	dUTP diphosphatase activity
HZF06_RS05585	COG0488	(ABC) transporter
HZF06_RS05595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZF06_RS05600	COG0205	6-phosphofructokinase activity
HZF06_RS05605	COG1971	Probably functions as a manganese efflux pump
HZF06_RS05615	COG1121	(ABC) transporter
HZF06_RS05630	COG1164	Oligoendopeptidase f
HZF06_RS05635	COG0705	Rhomboid family
HZF06_RS05635	COG0457	Tetratricopeptide repeat
HZF06_RS05640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZF06_RS05650	COG0328	RNA-DNA hybrid ribonuclease activity
HZF06_RS05670	COG1408	metallophosphoesterase
HZF06_RS05675	COG2207	Transcriptional regulator
HZF06_RS05675	COG1917	Cupin 2, conserved barrel domain protein
HZF06_RS05685	COG2204	response regulator
HZF06_RS05690	COG5002	protein histidine kinase activity
HZF06_RS05700	COG3191	aminopeptidase activity
HZF06_RS05705	COG4684	Psort location CytoplasmicMembrane, score
HZF06_RS05715	COG1125	glycine betaine transport
HZF06_RS05715	COG0517	IMP dehydrogenase activity
HZF06_RS05720	COG1732	Glycine betaine
HZF06_RS05725	COG0617	tRNA 3'-terminal CCA addition
HZF06_RS05730	COG2022	thiamine diphosphate biosynthetic process
HZF06_RS05730	COG2104	thiamine diphosphate biosynthetic process
HZF06_RS05740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZF06_RS05745	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZF06_RS05750	COG0352	thiamine-phosphate diphosphorylase activity
HZF06_RS05795	COG0083	homoserine kinase activity
HZF06_RS05810	COG1104	cysteine desulfurase activity
HZF06_RS05815	COG0301	tRNA thio-modification
HZF06_RS05860	COG1187	pseudouridine synthase activity
HZF06_RS05865	COG3547	Transposase (IS116 IS110 IS902 family)
HZF06_RS05875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZF06_RS05880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZF06_RS05885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZF06_RS05890	COG0131	Imidazoleglycerol-phosphate dehydratase
HZF06_RS05895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZF06_RS05905	COG0107	imidazoleglycerol-phosphate synthase activity
HZF06_RS05915	COG0140	phosphoribosyl-ATP diphosphatase activity
HZF06_RS05935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZF06_RS05955	COG1196	nuclear chromosome segregation
HZF06_RS05955	COG0739	heme binding
HZF06_RS05955	COG0741	lytic transglycosylase activity
HZF06_RS05965	COG1136	(ABC) transporter
HZF06_RS05970	COG0577	efflux transmembrane transporter activity
HZF06_RS06000	COG1067	ATP-dependent peptidase activity
HZF06_RS06000	COG0470	DNA polymerase III
HZF06_RS06005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZF06_RS06010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZF06_RS06045	COG0735	belongs to the Fur family
HZF06_RS06060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZF06_RS06075	COG0849	cell division
HZF06_RS06080	COG1473	amidohydrolase
HZF06_RS06085	COG0564	pseudouridine synthase activity
HZF06_RS06090	COG2244	polysaccharide biosynthetic process
HZF06_RS06095	COG2244	polysaccharide biosynthetic process
HZF06_RS06130	COG1269	ATP hydrolysis coupled proton transport
HZF06_RS06160	COG1394	ATPase activity, coupled to movement of substances
HZF06_RS06165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZF06_RS06170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZF06_RS06175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZF06_RS06195	COG3973	AAA domain
HZF06_RS06225	COG0598	Magnesium transport protein CorA
HZF06_RS06230	COG1362	aminopeptidase activity
HZF06_RS06235	COG1695	Transcriptional regulator
HZF06_RS06255	COG4177	L-phenylalanine transmembrane transporter activity
HZF06_RS06265	COG0683	leucine binding
HZF06_RS06275	COG0613	PHP domain protein
HZF06_RS06280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZF06_RS06280	COG0512	Glutamine amidotransferase of anthranilate synthase
HZF06_RS06285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZF06_RS06300	COG1418	mRNA catabolic process
HZF06_RS06305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZF06_RS06310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZF06_RS06310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZF06_RS06345	COG0582	viral genome integration into host DNA
HZF06_RS06370	COG1484	DNA-dependent DNA replication
HZF06_RS06535	COG1196	nuclear chromosome segregation
HZF06_RS06550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZF06_RS06640	COG2207	Transcriptional regulator
HZF06_RS06670	COG0772	Belongs to the SEDS family
HZF06_RS06675	COG1695	Transcriptional regulator
HZF06_RS06745	COG0656	L-ascorbic acid biosynthetic process
HZF06_RS06750	COG0406	alpha-ribazole phosphatase activity
HZF06_RS06755	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS06765	COG1979	alcohol dehydrogenase
HZF06_RS06800	COG1131	(ABC) transporter
HZF06_RS06830	COG1136	(ABC) transporter
HZF06_RS06830	COG0577	efflux transmembrane transporter activity
HZF06_RS06845	COG1737	Transcriptional regulator
HZF06_RS06850	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZF06_RS06855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZF06_RS06860	COG0371	Dehydrogenase
HZF06_RS06870	COG3716	PTS system mannose fructose sorbose family IID component
HZF06_RS06890	COG1312	Catalyzes the dehydration of D-mannonate
HZF06_RS06895	COG0800	Aldolase
HZF06_RS06900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZF06_RS06905	COG1652	LysM domain
HZF06_RS06905	COG2823	Periplasmic or secreted lipoprotein
HZF06_RS06955	COG0628	permease
HZF06_RS06960	COG0588	phosphoglycerate mutase activity
HZF06_RS06990	COG1131	(ABC) transporter
HZF06_RS07005	COG0519	Catalyzes the synthesis of GMP from XMP
HZF06_RS07015	COG2226	methyltransferase
HZF06_RS07025	COG0789	Transcriptional regulator
HZF06_RS07030	COG0546	phosphoglycolate phosphatase activity
HZF06_RS07035	COG3547	Transposase (IS116 IS110 IS902 family)
HZF06_RS07045	COG1595	DNA-templated transcription, initiation
HZF06_RS07070	COG0535	radical SAM domain protein
HZF06_RS07080	COG2205	protein histidine kinase activity
HZF06_RS07120	COG1131	(ABC) transporter
HZF06_RS07125	COG5002	protein histidine kinase activity
HZF06_RS07130	COG0745	RESPONSE REGULATOR receiver
HZF06_RS07150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS07155	COG0765	amino acid transport
HZF06_RS07160	COG2508	Transcriptional regulator
HZF06_RS07165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZF06_RS07170	COG1979	alcohol dehydrogenase
HZF06_RS07175	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HZF06_RS07180	COG0673	inositol 2-dehydrogenase activity
HZF06_RS07185	COG2378	regulation of single-species biofilm formation
HZF06_RS07190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZF06_RS07195	COG1360	Flagellar Motor Protein
HZF06_RS07210	COG0561	phosphatase activity
HZF06_RS07250	COG3711	transcriptional antiterminator
HZF06_RS07250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS07255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS07260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07270	COG0800	Aldolase
HZF06_RS07275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZF06_RS07285	COG0789	Transcriptional regulator
HZF06_RS07285	COG4978	Transcriptional regulator
HZF06_RS07290	COG1131	(ABC) transporter
HZF06_RS07315	COG5002	protein histidine kinase activity
HZF06_RS07320	COG0745	RESPONSE REGULATOR receiver
HZF06_RS07350	COG0393	Putative heavy-metal-binding
HZF06_RS07360	COG1309	transcriptional regulator
HZF06_RS07375	COG1363	Peptidase, m42
HZF06_RS07385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS07390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS07395	COG0006	proline dipeptidase activity
HZF06_RS07400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZF06_RS07405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZF06_RS07410	COG1846	Transcriptional regulator
HZF06_RS07415	COG0477	Major facilitator Superfamily
HZF06_RS07440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZF06_RS07465	COG4086	secreted protein
HZF06_RS07480	COG5492	domain, Protein
HZF06_RS07490	COG3711	transcriptional antiterminator
HZF06_RS07490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS07495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS07495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS07505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS07510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZF06_RS07510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZF06_RS07515	COG0534	Mate efflux family protein
HZF06_RS07530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZF06_RS07560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZF06_RS07565	COG4566	intracellular signal transduction
HZF06_RS07575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZF06_RS07585	COG3069	C4-dicarboxylate transmembrane transporter activity
HZF06_RS07600	COG0024	Methionine aminopeptidase
HZF06_RS07610	COG0814	amino acid
HZF06_RS07615	COG0697	spore germination
HZF06_RS07625	COG2226	methyltransferase
HZF06_RS07635	COG4555	ABC transporter
HZF06_RS07645	COG0640	Transcriptional regulator
HZF06_RS07650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS07655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS07655	COG2213	PTS system mannitol-specific
HZF06_RS07660	COG3414	Phosphotransferase system galactitol-specific IIB component
HZF06_RS07665	COG3775	system Galactitol-specific IIC component
HZF06_RS07680	COG2814	Major facilitator Superfamily
HZF06_RS07690	COG1309	transcriptional regulator
HZF06_RS07710	COG2188	Transcriptional regulator
HZF06_RS07720	COG4821	SIS domain
HZF06_RS07725	COG0745	RESPONSE REGULATOR receiver
HZF06_RS07740	COG5002	protein histidine kinase activity
HZF06_RS07745	COG0745	RESPONSE REGULATOR receiver
HZF06_RS07750	COG0642	Histidine kinase
HZF06_RS07755	COG1136	(ABC) transporter
HZF06_RS07765	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HZF06_RS07770	COG0840	transmembrane signaling receptor activity
HZF06_RS07780	COG5002	protein histidine kinase activity
HZF06_RS07790	COG1131	(ABC) transporter
HZF06_RS07805	COG5002	protein histidine kinase activity
HZF06_RS07830	COG5444	nuclease activity
HZF06_RS07950	COG0583	DNA-binding transcription factor activity
HZF06_RS07960	COG1132	(ABC) transporter
HZF06_RS07975	COG0596	Alpha beta hydrolase
HZF06_RS08025	COG3340	Belongs to the peptidase S51 family
HZF06_RS08040	COG0456	acetyltransferase
HZF06_RS08045	COG1335	isochorismatase
HZF06_RS08050	COG1396	sequence-specific DNA binding
HZF06_RS08065	COG0693	protein deglycase activity
HZF06_RS08090	COG1695	Transcriptional regulator
HZF06_RS08105	COG1309	transcriptional regulator
HZF06_RS08110	COG1012	belongs to the aldehyde dehydrogenase family
HZF06_RS08165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZF06_RS08220	COG0275	rRNA processing
HZF06_RS08235	COG1595	DNA-templated transcription, initiation
HZF06_RS08245	COG2207	Transcriptional regulator
HZF06_RS08245	COG3708	Transcriptional regulator
HZF06_RS08260	COG1247	-acetyltransferase
HZF06_RS08270	COG1846	Transcriptional regulator
HZF06_RS08290	COG1733	regulation of RNA biosynthetic process
HZF06_RS08295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZF06_RS08295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZF06_RS08300	COG3290	protein histidine kinase activity
HZF06_RS08300	COG3829	transcription factor binding
HZF06_RS08305	COG2376	Dihydroxyacetone kinase
HZF06_RS08315	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HZF06_RS08330	COG1418	mRNA catabolic process
HZF06_RS08350	COG1396	sequence-specific DNA binding
HZF06_RS08355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZF06_RS08415	COG5002	protein histidine kinase activity
HZF06_RS08420	COG0477	Major facilitator Superfamily
HZF06_RS08465	COG0673	inositol 2-dehydrogenase activity
HZF06_RS08475	COG1846	Transcriptional regulator
HZF06_RS08515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZF06_RS08530	COG3708	Transcriptional regulator
HZF06_RS08530	COG2207	Transcriptional regulator
HZF06_RS08535	COG1733	regulation of RNA biosynthetic process
HZF06_RS08540	COG0667	Aldo Keto reductase
HZF06_RS08545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZF06_RS08545	COG0646	methionine synthase
HZF06_RS08560	COG0003	Pfam Anion-transporting ATPase
HZF06_RS08570	COG0003	Pfam Anion-transporting ATPase
HZF06_RS08575	COG1522	sequence-specific DNA binding
HZF06_RS08580	COG1027	Aspartate ammonia-lyase
HZF06_RS08585	COG1113	amino acid transport
HZF06_RS08605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZF06_RS08610	COG3290	protein histidine kinase activity
HZF06_RS08615	COG4565	transcriptional regulatory protein
HZF06_RS08620	COG1053	succinate dehydrogenase
HZF06_RS08625	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HZF06_RS08625	COG3976	FMN-binding domain protein
HZF06_RS08630	COG0110	maltose O-acetyltransferase activity
HZF06_RS08640	COG3620	sequence-specific DNA binding
HZF06_RS08645	COG2323	membrane
HZF06_RS08670	COG1349	DNA-binding transcription factor activity
HZF06_RS08675	COG1349	DNA-binding transcription factor activity
HZF06_RS08690	COG0024	Methionine aminopeptidase
HZF06_RS08700	COG0456	acetyltransferase
HZF06_RS08715	COG4978	Transcriptional regulator
HZF06_RS08715	COG0789	Transcriptional regulator
HZF06_RS08720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZF06_RS08725	COG1187	pseudouridine synthase activity
HZF06_RS08755	COG0697	spore germination
HZF06_RS08775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZF06_RS08805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZF06_RS08810	COG5278	phosphoserine phosphatase activity
HZF06_RS08810	COG0840	transmembrane signaling receptor activity
HZF06_RS08815	COG0628	permease
HZF06_RS08820	COG4978	Transcriptional regulator
HZF06_RS08820	COG0789	Transcriptional regulator
HZF06_RS08835	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZF06_RS08840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZF06_RS08845	COG4335	DNA alkylation repair
HZF06_RS08850	COG4213	ABC transporter substrate-binding protein
HZF06_RS08855	COG4213	ABC transporter substrate-binding protein
HZF06_RS08865	COG0768	penicillin binding
HZF06_RS08885	COG1472	Belongs to the glycosyl hydrolase 3 family
HZF06_RS08890	COG2703	oxygen carrier activity
HZF06_RS08895	COG0297	glycogen (starch) synthase activity
HZF06_RS08910	COG0494	nUDIX hydrolase
HZF06_RS08915	COG3442	glutamine amidotransferase
HZF06_RS08920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZF06_RS08930	COG1482	cell wall glycoprotein biosynthetic process
HZF06_RS08965	COG2002	toxin-antitoxin pair type II binding
HZF06_RS08975	COG0840	transmembrane signaling receptor activity
HZF06_RS09010	COG0167	dihydroorotate dehydrogenase activity
HZF06_RS09015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZF06_RS09035	COG0501	Belongs to the peptidase M48B family
HZF06_RS09045	COG0010	Belongs to the arginase family
HZF06_RS09055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HZF06_RS09055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HZF06_RS09065	COG5434	Belongs to the glycosyl hydrolase 28 family
HZF06_RS09065	COG4632	Exopolysaccharide biosynthesis protein
HZF06_RS09075	COG1994	Peptidase M50
HZF06_RS09095	COG0248	Ppx GppA phosphatase
HZF06_RS09135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZF06_RS09155	COG2155	Conserved Protein
HZF06_RS09160	COG1522	sequence-specific DNA binding
HZF06_RS09170	COG4692	amylo-alpha-1,6-glucosidase activity
HZF06_RS09180	COG2996	Protein conserved in bacteria
HZF06_RS09215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZF06_RS09220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZF06_RS09225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HZF06_RS09230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZF06_RS09235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZF06_RS09245	COG0151	Belongs to the GarS family
HZF06_RS09250	COG1696	Membrane protein involved in D-alanine export
HZF06_RS09265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZF06_RS09270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZF06_RS09275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZF06_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS09285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZF06_RS09290	COG0511	ligase activity, forming carbon-carbon bonds
HZF06_RS09300	COG0439	Biotin carboxylase
HZF06_RS09305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZF06_RS09325	COG1131	(ABC) transporter
HZF06_RS09345	COG4120	Belongs to the binding-protein-dependent transport system permease family
HZF06_RS09370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZF06_RS09380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZF06_RS09390	COG1959	2 iron, 2 sulfur cluster binding
HZF06_RS09410	COG0583	DNA-binding transcription factor activity
HZF06_RS09430	COG2226	methyltransferase
HZF06_RS09495	COG1309	transcriptional regulator
HZF06_RS09640	COG0242	peptide deformylase activity
HZF06_RS09655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZF06_RS09660	COG1396	sequence-specific DNA binding
HZF06_RS09735	COG0456	acetyltransferase
HZF06_RS09760	COG2086	electron transfer activity
HZF06_RS09765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZF06_RS09770	COG1620	l-lactate permease
HZF06_RS09775	COG0277	FAD linked oxidase domain protein
HZF06_RS09780	COG1960	acyl-CoA dehydrogenase activity
HZF06_RS09790	COG2226	methyltransferase
HZF06_RS09850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZF06_RS09870	COG0735	belongs to the Fur family
HZF06_RS09875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZF06_RS09890	COG4122	O-methyltransferase activity
HZF06_RS09900	COG0572	uridine kinase
HZF06_RS09925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZF06_RS09935	COG1191	sigma factor activity
HZF06_RS09940	COG1191	sigma factor activity
HZF06_RS09945	COG1873	PFAM PRC-barrel domain
HZF06_RS09960	COG0745	RESPONSE REGULATOR receiver
HZF06_RS09970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZF06_RS09975	COG0573	inorganic phosphate transmembrane transporter activity
HZF06_RS09980	COG0581	inorganic phosphate transmembrane transporter activity
HZF06_RS09985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZF06_RS09990	COG0704	Plays a role in the regulation of phosphate uptake
HZF06_RS10010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HZF06_RS10020	COG0582	viral genome integration into host DNA
HZF06_RS10055	COG1396	sequence-specific DNA binding
HZF06_RS10080	COG1192	Involved in chromosome partitioning
HZF06_RS10100	COG0629	single-stranded DNA binding
HZF06_RS10115	COG2002	toxin-antitoxin pair type II binding
HZF06_RS10270	COG3409	Peptidoglycan-binding domain 1 protein
HZF06_RS10270	COG3757	hydrolase, family 25
HZF06_RS10325	COG4213	ABC transporter substrate-binding protein
HZF06_RS10360	COG2252	PERMEase
HZF06_RS10365	COG1561	YicC-like family, N-terminal region
HZF06_RS10385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZF06_RS10390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZF06_RS10395	COG0242	peptide deformylase activity
HZF06_RS10405	COG2738	Putative neutral zinc metallopeptidase
HZF06_RS10410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZF06_RS10410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZF06_RS10420	COG0631	protein serine/threonine phosphatase activity
HZF06_RS10430	COG1162	GTPase activity
HZF06_RS10435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZF06_RS10455	COG1302	Protein conserved in bacteria
HZF06_RS10460	COG1461	Dihydroxyacetone kinase
HZF06_RS10465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZF06_RS10470	COG0742	ribosomal rna small subunit methyltransferase
HZF06_RS10490	COG1323	Belongs to the UPF0348 family
HZF06_RS10495	COG0280	phosphate acetyltransferase
HZF06_RS10540	COG0552	protein localization to endoplasmic reticulum
HZF06_RS10545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HZF06_RS10550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZF06_RS10560	COG1837	Belongs to the UPF0109 family
HZF06_RS10575	COG0335	large ribosomal subunit rRNA binding
HZF06_RS10585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZF06_RS10595	COG0606	chelatase, subunit chli
HZF06_RS10600	COG0758	DNA mediated transformation
HZF06_RS10605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZF06_RS10615	COG0052	Belongs to the universal ribosomal protein uS2 family
HZF06_RS10640	COG4589	Belongs to the CDS family
HZF06_RS10645	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZF06_RS10665	COG0779	Required for maturation of 30S ribosomal subunits
HZF06_RS10670	COG0195	Participates in both transcription termination and antitermination
HZF06_RS10675	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HZF06_RS10695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZF06_RS10705	COG0196	riboflavin kinase activity
HZF06_RS10720	COG0612	Peptidase, M16
HZF06_RS10730	COG0527	aspartate kinase activity
HZF06_RS10735	COG0740	serine-type endopeptidase activity
HZF06_RS10740	COG1674	ftsk spoiiie
HZF06_RS10745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZF06_RS10750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZF06_RS10765	COG2359	stage V sporulation protein S
HZF06_RS10770	COG0613	PHP domain protein
HZF06_RS10775	COG0436	Aminotransferase
HZF06_RS10780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS10800	COG4974	Belongs to the 'phage' integrase family
HZF06_RS10810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZF06_RS10815	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HZF06_RS10820	COG1923	regulation of RNA biosynthetic process
HZF06_RS10840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZF06_RS10860	COG0539	negative regulation of cytoplasmic translation
HZF06_RS10860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZF06_RS10865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZF06_RS10870	COG2081	HI0933 family
HZF06_RS10875	COG1737	Transcriptional regulator
HZF06_RS10880	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HZF06_RS10885	COG1187	pseudouridine synthase activity
HZF06_RS10905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZF06_RS10910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HZF06_RS10915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZF06_RS10920	COG0445	tRNA wobble uridine modification
HZF06_RS10935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZF06_RS10935	COG0723	plastoquinol--plastocyanin reductase activity
HZF06_RS10940	COG1072	(Pantothenic acid kinase))
HZF06_RS10970	COG0697	spore germination
HZF06_RS11000	COG1741	Belongs to the pirin family
HZF06_RS11005	COG1733	regulation of RNA biosynthetic process
HZF06_RS11015	COG4989	oxidoreductase activity
HZF06_RS11030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZF06_RS11035	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS11040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZF06_RS11045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZF06_RS11050	COG1116	anion transmembrane transporter activity
HZF06_RS11055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HZF06_RS11060	COG5002	protein histidine kinase activity
HZF06_RS11085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZF06_RS11100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS11110	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS11115	COG0697	spore germination
HZF06_RS11125	COG0322	excinuclease ABC activity
HZF06_RS11150	COG1982	Orn Lys Arg decarboxylase major
HZF06_RS11180	COG1126	abc transporter atp-binding protein
HZF06_RS11185	COG0765	amino acid transport
HZF06_RS11190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS11195	COG0252	asparaginase activity
HZF06_RS11210	COG0504	CTP synthase activity
HZF06_RS11225	COG0697	spore germination
HZF06_RS11230	COG3958	Transketolase
HZF06_RS11235	COG3959	Transketolase, thiamine diphosphate binding domain
HZF06_RS11240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS11245	COG3711	transcriptional antiterminator
HZF06_RS11250	COG3037	sugar-specific permease SgaT UlaA
HZF06_RS11260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS11270	COG1011	Hydrolase
HZF06_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS11285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZF06_RS11290	COG5002	protein histidine kinase activity
HZF06_RS11295	COG0745	RESPONSE REGULATOR receiver
HZF06_RS11305	COG0577	efflux transmembrane transporter activity
HZF06_RS11305	COG1136	(ABC) transporter
HZF06_RS11310	COG0840	transmembrane signaling receptor activity
HZF06_RS11315	COG0352	thiamine-phosphate diphosphorylase activity
HZF06_RS11320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZF06_RS11345	COG1397	ADP-ribosylglycohydrolase
HZF06_RS11360	COG1357	PFAM Pentapeptide repeats (8 copies)
HZF06_RS11365	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HZF06_RS11375	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS11380	COG0679	Auxin Efflux Carrier
HZF06_RS11395	COG0791	NLP P60 protein
HZF06_RS11395	COG3103	Sh3 type 3 domain protein
HZF06_RS11395	COG1388	LysM domain
HZF06_RS11405	COG0517	IMP dehydrogenase activity
HZF06_RS11405	COG1125	glycine betaine transport
HZF06_RS11410	COG1732	Glycine betaine
HZF06_RS11415	COG1174	glycine betaine transport
HZF06_RS11425	COG3300	MHYT domain
HZF06_RS11425	COG5001	Diguanylate cyclase
HZF06_RS11435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZF06_RS11440	COG1011	Hydrolase
HZF06_RS11460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZF06_RS11480	COG5002	protein histidine kinase activity
HZF06_RS11485	COG3757	hydrolase, family 25
HZF06_RS11485	COG3409	Peptidoglycan-binding domain 1 protein
HZF06_RS11500	COG1151	hydroxylamine reductase activity
HZF06_RS11505	COG2824	Alkylphosphonate utilization operon protein PhnA
HZF06_RS11525	COG2378	regulation of single-species biofilm formation
HZF06_RS11530	COG0577	efflux transmembrane transporter activity
HZF06_RS11530	COG1136	(ABC) transporter
HZF06_RS11540	COG1309	transcriptional regulator
HZF06_RS11545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZF06_RS11550	COG1328	CTP reductase activity
HZF06_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS11595	COG0789	Transcriptional regulator
HZF06_RS11640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZF06_RS11645	COG4977	sequence-specific DNA binding
HZF06_RS11645	COG1917	Cupin 2, conserved barrel domain protein
HZF06_RS11650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZF06_RS11655	COG0561	phosphatase activity
HZF06_RS11665	COG2255	four-way junction helicase activity
HZF06_RS11695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZF06_RS11700	COG0577	efflux transmembrane transporter activity
HZF06_RS11705	COG1136	(ABC) transporter
HZF06_RS11725	COG3757	hydrolase, family 25
HZF06_RS11725	COG3409	Peptidoglycan-binding domain 1 protein
HZF06_RS11730	COG4824	toxin secretion phage lysis holin
HZF06_RS11805	COG0740	serine-type endopeptidase activity
HZF06_RS11860	COG0629	single-stranded DNA binding
HZF06_RS12025	COG0582	viral genome integration into host DNA
HZF06_RS12040	COG0789	Transcriptional regulator
HZF06_RS12055	COG1136	(ABC) transporter
HZF06_RS12060	COG2205	protein histidine kinase activity
HZF06_RS12065	COG0745	RESPONSE REGULATOR receiver
HZF06_RS12130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZF06_RS12165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZF06_RS12180	COG1309	transcriptional regulator
HZF06_RS12190	COG3576	pyridoxamine 5-phosphate
HZF06_RS12195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZF06_RS12230	COG0242	peptide deformylase activity
HZF06_RS12265	COG0642	Histidine kinase
HZF06_RS12270	COG0745	RESPONSE REGULATOR receiver
HZF06_RS12275	COG2059	Chromate
HZF06_RS12280	COG1695	Transcriptional regulator
HZF06_RS12285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HZF06_RS12290	COG0583	DNA-binding transcription factor activity
HZF06_RS12295	COG2890	protein-(glutamine-N5) methyltransferase activity
HZF06_RS12320	COG0561	phosphatase activity
HZF06_RS12330	COG0375	protein maturation
HZF06_RS12360	COG1595	DNA-templated transcription, initiation
HZF06_RS12380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZF06_RS12400	COG0280	phosphate acetyltransferase
HZF06_RS12405	COG2030	dehydratase
HZF06_RS12415	COG2267	carboxylic ester hydrolase activity
HZF06_RS12420	COG0427	acetyl-CoA hydrolase
HZF06_RS12450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZF06_RS12455	COG0596	Alpha beta hydrolase
HZF06_RS12495	COG1733	regulation of RNA biosynthetic process
HZF06_RS12505	COG3708	Transcriptional regulator
HZF06_RS12505	COG2207	Transcriptional regulator
HZF06_RS12515	COG1733	regulation of RNA biosynthetic process
HZF06_RS12535	COG1131	(ABC) transporter
HZF06_RS12565	COG0798	PFAM Bile acid sodium symporter
HZF06_RS12570	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZF06_RS12595	COG2226	methyltransferase
HZF06_RS12615	COG2198	Histidine kinase
HZF06_RS12615	COG2205	protein histidine kinase activity
HZF06_RS12615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS12615	COG0784	Response regulator, receiver
HZF06_RS12625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZF06_RS12630	COG0789	Transcriptional regulator
HZF06_RS12640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZF06_RS12645	COG2378	regulation of single-species biofilm formation
HZF06_RS12650	COG1846	Transcriptional regulator
HZF06_RS12670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZF06_RS12675	COG1595	DNA-templated transcription, initiation
HZF06_RS12695	COG1131	(ABC) transporter
HZF06_RS12705	COG0840	transmembrane signaling receptor activity
HZF06_RS12710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZF06_RS12720	COG0789	Transcriptional regulator
HZF06_RS12725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HZF06_RS12740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZF06_RS12745	COG0596	Alpha beta hydrolase
HZF06_RS12770	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS12775	COG0475	glutathione-regulated potassium exporter activity
HZF06_RS12775	COG0589	response to stress
HZF06_RS12780	COG0488	(ABC) transporter
HZF06_RS12800	COG0277	FAD linked oxidase domain protein
HZF06_RS12805	COG2226	methyltransferase
HZF06_RS12810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZF06_RS12815	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZF06_RS12825	COG2205	protein histidine kinase activity
HZF06_RS12830	COG0745	RESPONSE REGULATOR receiver
HZF06_RS12855	COG0596	Alpha beta hydrolase
HZF06_RS12870	COG1695	Transcriptional regulator
HZF06_RS12875	COG0628	permease
HZF06_RS12890	COG1136	(ABC) transporter
HZF06_RS12890	COG0577	efflux transmembrane transporter activity
HZF06_RS12925	COG2205	protein histidine kinase activity
HZF06_RS12930	COG4213	ABC transporter substrate-binding protein
HZF06_RS12935	COG3103	Sh3 type 3 domain protein
HZF06_RS12935	COG4991	sh3 domain protein
HZF06_RS12935	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZF06_RS12945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZF06_RS12955	COG0561	phosphatase activity
HZF06_RS12965	COG0039	L-malate dehydrogenase activity
HZF06_RS12970	COG2213	PTS system mannitol-specific
HZF06_RS12970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS12975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS12975	COG3711	transcriptional antiterminator
HZF06_RS12995	COG2378	regulation of single-species biofilm formation
HZF06_RS13000	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS13025	COG2239	Acts as a magnesium transporter
HZF06_RS13030	COG1396	sequence-specific DNA binding
HZF06_RS13070	COG3209	COG3209 Rhs family protein
HZF06_RS13085	COG3409	Peptidoglycan-binding domain 1 protein
HZF06_RS13085	COG3757	hydrolase, family 25
HZF06_RS13205	COG5484	DNA packaging
HZF06_RS13225	COG5492	domain, Protein
HZF06_RS13235	COG5492	domain, Protein
HZF06_RS13285	COG1192	Involved in chromosome partitioning
HZF06_RS13320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZF06_RS13360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZF06_RS13365	COG1116	anion transmembrane transporter activity
HZF06_RS13370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZF06_RS13380	COG1346	cytolysis
HZF06_RS13390	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HZF06_RS13395	COG0745	RESPONSE REGULATOR receiver
HZF06_RS13410	COG2205	protein histidine kinase activity
HZF06_RS13450	COG0745	RESPONSE REGULATOR receiver
HZF06_RS13465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZF06_RS13475	COG1131	(ABC) transporter
HZF06_RS13520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZF06_RS13520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZF06_RS13525	COG2309	aminopeptidase activity
HZF06_RS13555	COG2267	carboxylic ester hydrolase activity
HZF06_RS13575	COG1404	Belongs to the peptidase S8 family
HZF06_RS13585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZF06_RS13605	COG1131	(ABC) transporter
HZF06_RS13610	COG2205	protein histidine kinase activity
HZF06_RS13615	COG0745	RESPONSE REGULATOR receiver
HZF06_RS13625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZF06_RS13635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZF06_RS13640	COG1136	(ABC) transporter
HZF06_RS13655	COG1136	(ABC) transporter
HZF06_RS13660	COG1309	transcriptional regulator
HZF06_RS13665	COG2378	regulation of single-species biofilm formation
HZF06_RS13670	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HZF06_RS13685	COG3576	pyridoxamine 5-phosphate
HZF06_RS13695	COG3875	lactate racemase activity
HZF06_RS13700	COG0840	transmembrane signaling receptor activity
HZF06_RS13700	COG3290	protein histidine kinase activity
HZF06_RS13730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZF06_RS13735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZF06_RS13740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZF06_RS13745	COG1454	alcohol dehydrogenase
HZF06_RS13750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZF06_RS13765	COG1131	(ABC) transporter
HZF06_RS13770	COG1725	Transcriptional regulator
HZF06_RS13780	COG1132	(ABC) transporter
HZF06_RS13790	COG2207	Transcriptional regulator
HZF06_RS13790	COG1609	Transcriptional regulator
HZF06_RS13800	COG4213	ABC transporter substrate-binding protein
HZF06_RS13805	COG1609	Transcriptional regulator
HZF06_RS13810	COG0366	Alpha amylase catalytic
HZF06_RS13815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZF06_RS13825	COG0519	Catalyzes the synthesis of GMP from XMP
HZF06_RS13830	COG0789	Transcriptional regulator
HZF06_RS13855	COG0083	homoserine kinase activity
HZF06_RS13860	COG1304	FMN binding
HZF06_RS13870	COG3142	Participates in the control of copper homeostasis
HZF06_RS13875	COG3973	AAA domain
HZF06_RS13880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZF06_RS13890	COG5002	protein histidine kinase activity
HZF06_RS13900	COG5564	TIM-barrel signal transduction protein
HZF06_RS13910	COG5564	TIM-barrel signal transduction protein
HZF06_RS13915	COG4213	ABC transporter substrate-binding protein
HZF06_RS13920	COG4213	ABC transporter substrate-binding protein
HZF06_RS13930	COG0191	fructose-bisphosphate aldolase activity
HZF06_RS13940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS13940	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HZF06_RS13940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS13945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS13950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS13950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS13950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZF06_RS13965	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS13970	COG1304	FMN binding
HZF06_RS13980	COG5002	protein histidine kinase activity
HZF06_RS14060	COG4716	Myosin-crossreactive antigen
HZF06_RS14065	COG4978	Transcriptional regulator
HZF06_RS14065	COG0789	Transcriptional regulator
HZF06_RS14075	COG2814	Major facilitator Superfamily
HZF06_RS14095	COG0484	heat shock protein binding
HZF06_RS14110	COG0426	domain, Protein
HZF06_RS14120	COG0569	domain protein
HZF06_RS14125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZF06_RS14130	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HZF06_RS14140	COG1045	serine acetyltransferase
HZF06_RS14150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZF06_RS14155	COG0346	lactoylglutathione lyase activity
HZF06_RS14170	COG4208	sulfate ABC transporter
HZF06_RS14175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HZF06_RS14180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HZF06_RS14185	COG1959	2 iron, 2 sulfur cluster binding
HZF06_RS14200	COG1486	melibiose metabolic process
HZF06_RS14205	COG1263	PTS System
HZF06_RS14205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS14215	COG0281	malic enzyme
HZF06_RS14230	COG1120	ATPase activity
HZF06_RS14235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZF06_RS14240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZF06_RS14245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZF06_RS14255	COG1408	metallophosphoesterase
HZF06_RS14265	COG0785	Cytochrome C biogenesis protein
HZF06_RS14275	COG0124	histidyl-tRNA synthetase
HZF06_RS14280	COG2197	response regulator
HZF06_RS14295	COG1131	(ABC) transporter
HZF06_RS14300	COG0534	Mate efflux family protein
HZF06_RS14305	COG1132	(ABC) transporter
HZF06_RS14310	COG1132	(ABC) transporter
HZF06_RS14320	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS14370	COG1686	Belongs to the peptidase S11 family
HZF06_RS14380	COG3874	Sporulation protein YtfJ
HZF06_RS14385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZF06_RS14390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZF06_RS14395	COG1686	Belongs to the peptidase S11 family
HZF06_RS14405	COG4974	Belongs to the 'phage' integrase family
HZF06_RS14425	COG0372	Belongs to the citrate synthase family
HZF06_RS14435	COG0745	RESPONSE REGULATOR receiver
HZF06_RS14440	COG0750	zinc metalloprotease
HZF06_RS14445	COG0497	DNA recombination
HZF06_RS14455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZF06_RS14460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HZF06_RS14465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZF06_RS14475	COG1722	exodeoxyribonuclease VII activity
HZF06_RS14480	COG1570	exodeoxyribonuclease VII activity
HZF06_RS14535	COG3854	ATPases associated with a variety of cellular activities
HZF06_RS14610	COG0116	Belongs to the methyltransferase superfamily
HZF06_RS14620	COG0564	pseudouridine synthase activity
HZF06_RS14630	COG3599	regulation of cell shape
HZF06_RS14645	COG1799	cell septum assembly
HZF06_RS14650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZF06_RS14660	COG3856	small basic protein
HZF06_RS14675	COG0772	Belongs to the SEDS family
HZF06_RS14685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZF06_RS14695	COG0768	penicillin binding
HZF06_RS14710	COG2001	Belongs to the MraZ family
HZF06_RS14715	COG0012	GTP binding
HZF06_RS14745	COG0728	peptidoglycan biosynthetic process
HZF06_RS14750	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZF06_RS14760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZF06_RS14765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZF06_RS14770	COG1982	Orn Lys Arg decarboxylase major
HZF06_RS14775	COG1683	Conserved Protein
HZF06_RS14780	COG1193	negative regulation of DNA recombination
HZF06_RS14785	COG0826	peptidase U32
HZF06_RS14800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZF06_RS14805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZF06_RS14810	COG0569	domain protein
HZF06_RS14815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZF06_RS14820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZF06_RS14855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZF06_RS14860	COG2226	methyltransferase
HZF06_RS14870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZF06_RS14875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZF06_RS14885	COG4166	transmembrane transport
HZF06_RS14890	COG4608	Belongs to the ABC transporter superfamily
HZF06_RS14895	COG0444	Belongs to the ABC transporter superfamily
HZF06_RS14900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZF06_RS14905	COG0601	transmembrane transport
HZF06_RS14910	COG0436	Aminotransferase
HZF06_RS14920	COG2171	N-acyltransferase activity
HZF06_RS14930	COG0726	polysaccharide deacetylase
HZF06_RS14950	COG1368	sulfuric ester hydrolase activity
HZF06_RS14955	COG0628	permease
HZF06_RS14960	COG0285	dihydrofolate synthase activity
HZF06_RS14965	COG0561	phosphatase activity
HZF06_RS14990	COG2137	regulation of response to DNA damage stimulus
HZF06_RS15000	COG0745	RESPONSE REGULATOR receiver
HZF06_RS15005	COG5002	protein histidine kinase activity
HZF06_RS15010	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS15030	COG2966	Psort location CytoplasmicMembrane, score
HZF06_RS15040	COG1937	Protein conserved in bacteria
HZF06_RS15050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZF06_RS15060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZF06_RS15065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZF06_RS15070	COG1490	D-aminoacyl-tRNA deacylase activity
HZF06_RS15075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZF06_RS15085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZF06_RS15085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZF06_RS15090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZF06_RS15095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZF06_RS15115	COG1862	Preprotein translocase
HZF06_RS15125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZF06_RS15135	COG0632	four-way junction helicase activity
HZF06_RS15140	COG0384	phenazine biosynthesis protein PhzF
HZF06_RS15165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZF06_RS15170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZF06_RS15185	COG1917	Cupin 2, conserved barrel domain protein
HZF06_RS15185	COG2207	Transcriptional regulator
HZF06_RS15190	COG0110	maltose O-acetyltransferase activity
HZF06_RS15195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZF06_RS15205	COG2190	(PTS) system
HZF06_RS15205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS15205	COG1263	PTS System
HZF06_RS15210	COG3711	transcriptional antiterminator
HZF06_RS15220	COG4667	esterase of the alpha-beta hydrolase superfamily
HZF06_RS15225	COG0396	ATPase activity
HZF06_RS15235	COG0719	Fe-S assembly protein
HZF06_RS15240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZF06_RS15270	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HZF06_RS15290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZF06_RS15315	COG0659	secondary active sulfate transmembrane transporter activity
HZF06_RS15370	COG0534	Mate efflux family protein
HZF06_RS15385	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HZF06_RS15395	COG1739	Uncharacterized protein family UPF0029
HZF06_RS15400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZF06_RS15415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZF06_RS15425	COG4213	ABC transporter substrate-binding protein
HZF06_RS15470	COG1476	TRANSCRIPTIONal
HZF06_RS15475	COG3842	ATPase activity
HZF06_RS15485	COG1177	transmembrane transport
HZF06_RS15505	COG1254	Belongs to the acylphosphatase family
HZF06_RS15515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZF06_RS15520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZF06_RS15525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HZF06_RS15540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZF06_RS15545	COG0646	methionine synthase
HZF06_RS15545	COG1410	methionine synthase
HZF06_RS15565	COG0671	phosphoesterase, PA-phosphatase related
HZF06_RS15575	COG0288	reversible hydration of carbon dioxide
HZF06_RS15580	COG1393	Belongs to the ArsC family
HZF06_RS15585	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZF06_RS15590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZF06_RS15590	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZF06_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS15605	COG2207	Transcriptional regulator
HZF06_RS15610	COG2119	membrane
HZF06_RS15615	COG0129	dihydroxy-acid dehydratase activity
HZF06_RS15630	COG2190	(PTS) system
HZF06_RS15640	COG1263	PTS System
HZF06_RS15640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS15650	COG0697	spore germination
HZF06_RS15655	COG1917	Cupin 2, conserved barrel domain protein
HZF06_RS15655	COG2207	Transcriptional regulator
HZF06_RS15660	COG0348	domain, Protein
HZF06_RS15695	COG1309	transcriptional regulator
HZF06_RS15705	COG0456	acetyltransferase
HZF06_RS15710	COG2816	NAD+ diphosphatase activity
HZF06_RS15715	COG3706	GGDEF domain
HZF06_RS15715	COG4251	negative regulation of phosphorylation
HZF06_RS15715	COG5001	Diguanylate cyclase
HZF06_RS15715	COG2203	Gaf domain
HZF06_RS15720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZF06_RS15730	COG1051	belongs to the nudix hydrolase family
HZF06_RS15765	COG0456	acetyltransferase
HZF06_RS15775	COG1051	belongs to the nudix hydrolase family
HZF06_RS15785	COG1396	sequence-specific DNA binding
HZF06_RS15790	COG0697	spore germination
HZF06_RS15805	COG0531	amino acid
HZF06_RS15835	COG3706	GGDEF domain
HZF06_RS15850	COG2267	carboxylic ester hydrolase activity
HZF06_RS15855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZF06_RS15885	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HZF06_RS15890	COG2720	vancomycin resistance protein
HZF06_RS15900	COG0789	Transcriptional regulator
HZF06_RS15905	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS15910	COG0534	Mate efflux family protein
HZF06_RS15920	COG0667	Aldo Keto reductase
HZF06_RS15965	COG2217	Heavy metal translocating P-type atpase
HZF06_RS15975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZF06_RS15985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZF06_RS15990	COG2207	Transcriptional regulator
HZF06_RS16005	COG1247	-acetyltransferase
HZF06_RS16095	COG1335	isochorismatase
HZF06_RS16100	COG1522	sequence-specific DNA binding
HZF06_RS16125	COG4213	ABC transporter substrate-binding protein
HZF06_RS16135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZF06_RS16140	COG4213	ABC transporter substrate-binding protein
HZF06_RS16145	COG0454	-acetyltransferase
HZF06_RS16150	COG0398	Pfam SNARE associated Golgi protein
HZF06_RS16155	COG0745	RESPONSE REGULATOR receiver
HZF06_RS16160	COG5002	protein histidine kinase activity
HZF06_RS16160	COG0642	Histidine kinase
HZF06_RS16180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZF06_RS16205	COG0673	inositol 2-dehydrogenase activity
HZF06_RS16225	COG1131	(ABC) transporter
HZF06_RS16240	COG0840	transmembrane signaling receptor activity
HZF06_RS16245	COG0740	serine-type endopeptidase activity
HZF06_RS16250	COG2207	Transcriptional regulator
HZF06_RS16255	COG1902	pentaerythritol trinitrate reductase activity
HZF06_RS16265	COG3706	GGDEF domain
HZF06_RS16270	COG0840	transmembrane signaling receptor activity
HZF06_RS16275	COG0745	RESPONSE REGULATOR receiver
HZF06_RS16280	COG5002	protein histidine kinase activity
HZF06_RS16295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZF06_RS16335	COG2894	cell division
HZF06_RS16340	COG3279	Response regulator of the LytR AlgR family
HZF06_RS16365	COG2384	SAM-dependent methyltransferase
HZF06_RS16375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZF06_RS16380	COG0358	DNA primase activity
HZF06_RS16395	COG0574	Belongs to the PEP-utilizing enzyme family
HZF06_RS16395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZF06_RS16415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZF06_RS16425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZF06_RS16435	COG1480	7TM receptor with intracellular HD hydrolase
HZF06_RS16455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZF06_RS16460	COG0537	adenosine 5'-monophosphoramidase activity
HZF06_RS16465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZF06_RS16470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZF06_RS16485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HZF06_RS16500	COG2252	PERMEase
HZF06_RS16515	COG0484	heat shock protein binding
HZF06_RS16520	COG0443	Heat shock 70 kDa protein
HZF06_RS16535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZF06_RS16540	COG0481	GTPase activity
HZF06_RS16555	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZF06_RS16565	COG1466	dna polymerase III delta subunit
HZF06_RS16575	COG2217	Heavy metal translocating P-type atpase
HZF06_RS16585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZF06_RS16600	COG2172	sigma factor antagonist activity
HZF06_RS16610	COG1067	ATP-dependent peptidase activity
HZF06_RS16615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HZF06_RS16620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZF06_RS16630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZF06_RS16640	COG0157	Belongs to the NadC ModD family
HZF06_RS16655	COG4844	belongs to the
HZF06_RS16685	COG1527	subunit (C
HZF06_RS16690	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HZF06_RS16695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZF06_RS16700	COG1269	ATP hydrolysis coupled proton transport
HZF06_RS16715	COG0569	domain protein
HZF06_RS16720	COG0347	Belongs to the P(II) protein family
HZF06_RS16725	COG0004	ammonium transporteR
HZF06_RS16730	COG1283	sodium-dependent phosphate transmembrane transporter activity
HZF06_RS16735	COG1486	melibiose metabolic process
HZF06_RS16740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZF06_RS16745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZF06_RS16760	COG4786	Flagellar basal body rod
HZF06_RS16775	COG1191	sigma factor activity
HZF06_RS16785	COG0455	bacterial-type flagellum organization
HZF06_RS16790	COG1419	protein localization to endoplasmic reticulum
HZF06_RS16795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZF06_RS16800	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZF06_RS16810	COG1338	Plays a role in the flagellum-specific transport system
HZF06_RS16835	COG1582	Flagellar protein (FlbD)
HZF06_RS16840	COG4786	Flagellar basal body rod
HZF06_RS16840	COG4786	Flagellar basal body rod
HZF06_RS16850	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZF06_RS16865	COG1157	protein secretion by the type III secretion system
HZF06_RS16875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZF06_RS16880	COG1766	The M ring may be actively involved in energy transduction
HZF06_RS16885	COG1677	Flagellar hook-basal body complex protein FliE
HZF06_RS16895	COG1815	bacterial-type flagellum-dependent cell motility
HZF06_RS16900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZF06_RS16905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZF06_RS16950	COG1216	Glycosyl transferase, family 2
HZF06_RS16955	COG1216	Glycosyl transferase, family 2
HZF06_RS16960	COG0457	Tetratricopeptide repeat
HZF06_RS16960	COG0463	Glycosyl transferase, family 2
HZF06_RS16965	COG0463	Glycosyl transferase, family 2
HZF06_RS16970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZF06_RS16975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZF06_RS16985	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZF06_RS17015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZF06_RS17020	COG1256	bacterial-type flagellum assembly
HZF06_RS17020	COG4786	Flagellar basal body rod
HZF06_RS17035	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZF06_RS17035	COG1776	CheC inhibitor of MCP methylation
HZF06_RS17040	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZF06_RS17045	COG0835	chemotaxis
HZF06_RS17050	COG2201	protein-glutamate methylesterase activity
HZF06_RS17055	COG1776	CheC inhibitor of MCP methylation
HZF06_RS17060	COG0643	Histidine kinase
HZF06_RS17060	COG2198	Histidine kinase
HZF06_RS17065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZF06_RS17070	COG2201	protein-glutamate methylesterase activity
HZF06_RS17075	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HZF06_RS17080	COG0835	chemotaxis
HZF06_RS17100	COG0037	tRNA processing
HZF06_RS17105	COG4708	membrane
HZF06_RS17110	COG0697	spore germination
HZF06_RS17160	COG1695	Transcriptional regulator
HZF06_RS17165	COG1983	PspC domain protein
HZF06_RS17170	COG0512	Glutamine amidotransferase of anthranilate synthase
HZF06_RS17170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZF06_RS17180	COG0133	tryptophan synthase activity
HZF06_RS17185	COG0135	phosphoribosylanthranilate isomerase activity
HZF06_RS17200	COG1234	tRNA 3'-trailer cleavage
HZF06_RS17210	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HZF06_RS17225	COG2264	protein methyltransferase activity
HZF06_RS17250	COG3546	catalase activity
HZF06_RS17255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HZF06_RS17280	COG0310	cobalt ion transport
HZF06_RS17285	COG1122	ATPase activity
HZF06_RS17300	COG4656	Part of a membrane complex involved in electron transport
HZF06_RS17330	COG1063	alcohol dehydrogenase
HZF06_RS17340	COG1309	transcriptional regulator
HZF06_RS17350	COG1305	Transglutaminase-like
HZF06_RS17360	COG0714	Associated with various cellular activities
HZF06_RS17370	COG1695	Transcriptional regulator
HZF06_RS17385	COG5002	protein histidine kinase activity
HZF06_RS17410	COG0737	Belongs to the 5'-nucleotidase family
HZF06_RS17435	COG0436	Aminotransferase
HZF06_RS17440	COG1522	sequence-specific DNA binding
HZF06_RS17450	COG0561	phosphatase activity
HZF06_RS17460	COG1263	PTS System
HZF06_RS17460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS17460	COG2190	(PTS) system
HZF06_RS17470	COG1263	PTS System
HZF06_RS17470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS17475	COG1737	Transcriptional regulator
HZF06_RS17480	COG5002	protein histidine kinase activity
HZF06_RS17485	COG0745	RESPONSE REGULATOR receiver
HZF06_RS17500	COG1131	(ABC) transporter
HZF06_RS17505	COG2190	(PTS) system
HZF06_RS17505	COG1263	PTS System
HZF06_RS17505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS17515	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZF06_RS17520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZF06_RS17525	COG0402	S-adenosylhomocysteine deaminase activity
HZF06_RS17540	COG0561	phosphatase activity
HZF06_RS17545	COG3716	PTS system mannose fructose sorbose family IID component
HZF06_RS17550	COG3715	PTS system
HZF06_RS17555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS17555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS17560	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS17560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS17565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS17565	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS17570	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZF06_RS17585	COG0613	PHP domain protein
HZF06_RS17590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZF06_RS17595	COG1132	(ABC) transporter
HZF06_RS17605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZF06_RS17610	COG1349	DNA-binding transcription factor activity
HZF06_RS17620	COG1132	(ABC) transporter
HZF06_RS17630	COG0789	Transcriptional regulator
HZF06_RS17630	COG4978	Transcriptional regulator
HZF06_RS17655	COG4820	ethanolamine utilization protein (EutJ)
HZF06_RS17660	COG4869	propanediol catabolic process
HZF06_RS17675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZF06_RS17680	COG3279	Response regulator of the LytR AlgR family
HZF06_RS17700	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HZF06_RS17725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZF06_RS17730	COG1882	Formate acetyltransferase
HZF06_RS17760	COG0277	FAD linked oxidase domain protein
HZF06_RS17775	COG1131	(ABC) transporter
HZF06_RS17780	COG2197	response regulator
HZF06_RS17785	COG4585	Histidine kinase
HZF06_RS17795	COG4565	transcriptional regulatory protein
HZF06_RS17800	COG3290	protein histidine kinase activity
HZF06_RS17810	COG0281	malic enzyme
HZF06_RS17815	COG3279	Response regulator of the LytR AlgR family
HZF06_RS17825	COG4864	UPF0365 protein
HZF06_RS17835	COG3290	protein histidine kinase activity
HZF06_RS17840	COG5002	protein histidine kinase activity
HZF06_RS17845	COG0662	Cupin 2, conserved barrel domain protein
HZF06_RS17870	COG1309	transcriptional regulator
HZF06_RS17880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZF06_RS17890	COG0745	RESPONSE REGULATOR receiver
HZF06_RS17895	COG5002	protein histidine kinase activity
HZF06_RS17905	COG3620	sequence-specific DNA binding
HZF06_RS17915	COG1120	ATPase activity
HZF06_RS17920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZF06_RS17925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZF06_RS17935	COG1396	sequence-specific DNA binding
HZF06_RS17945	COG1136	(ABC) transporter
HZF06_RS17950	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HZF06_RS17960	COG2814	Major facilitator Superfamily
HZF06_RS17965	COG0778	Nitroreductase
HZF06_RS17975	COG0488	(ABC) transporter
HZF06_RS17980	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS17985	COG2362	D-Aminopeptidase
HZF06_RS17990	COG2207	Transcriptional regulator
HZF06_RS18005	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS18015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS18020	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS18025	COG2188	Transcriptional regulator
HZF06_RS18030	COG3878	Protein conserved in bacteria
HZF06_RS18035	COG0778	Nitroreductase
HZF06_RS18040	COG3759	membrane
HZF06_RS18055	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HZF06_RS18070	COG1196	nuclear chromosome segregation
HZF06_RS18100	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HZF06_RS18105	COG1070	Carbohydrate kinase
HZF06_RS18120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZF06_RS18130	COG1737	Transcriptional regulator
HZF06_RS18160	COG0840	transmembrane signaling receptor activity
HZF06_RS18180	COG0557	exoribonuclease II activity
HZF06_RS18195	COG2217	Heavy metal translocating P-type atpase
HZF06_RS18200	COG0840	transmembrane signaling receptor activity
HZF06_RS18240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZF06_RS18245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZF06_RS18250	COG4149	molybdate abc transporter
HZF06_RS18255	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZF06_RS18260	COG0765	amino acid transport
HZF06_RS18265	COG0765	amino acid transport
HZF06_RS18270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS18280	COG0586	Pfam SNARE associated Golgi protein
HZF06_RS18290	COG1278	Cold shock
HZF06_RS18295	COG0183	Belongs to the thiolase family
HZF06_RS18310	COG3437	response regulator, receiver
HZF06_RS18330	COG1464	Belongs to the NlpA lipoprotein family
HZF06_RS18335	COG2011	ABC-type metal ion transport system permease component
HZF06_RS18340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZF06_RS18355	COG1686	Belongs to the peptidase S11 family
HZF06_RS18360	COG0564	pseudouridine synthase activity
HZF06_RS18370	COG1713	HD superfamily hydrolase involved in NAD metabolism
HZF06_RS18375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZF06_RS18380	COG1534	Rna-binding protein
HZF06_RS18385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZF06_RS18405	COG1530	ribonuclease E activity
HZF06_RS18420	COG1994	Peptidase M50
HZF06_RS18435	COG0772	Belongs to the SEDS family
HZF06_RS18440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZF06_RS18445	COG2894	cell division
HZF06_RS18450	COG0850	regulation of cytokinetic process
HZF06_RS18470	COG1077	Cell shape determining protein MreB Mrl
HZF06_RS18475	COG2003	Belongs to the UPF0758 family
HZF06_RS18480	COG0424	maF-like protein
HZF06_RS18490	COG0791	NLP P60 protein
HZF06_RS18490	COG1388	LysM domain
HZF06_RS18500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZF06_RS18510	COG0539	negative regulation of cytoplasmic translation
HZF06_RS18510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZF06_RS18530	COG0488	(ABC) transporter
HZF06_RS18555	COG2176	DNA-directed DNA polymerase activity
HZF06_RS18565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZF06_RS18590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZF06_RS18605	COG2203	Gaf domain
HZF06_RS18605	COG2199	diguanylate cyclase activity
HZF06_RS18610	COG3279	Response regulator of the LytR AlgR family
HZF06_RS18620	COG3279	Response regulator of the LytR AlgR family
HZF06_RS18625	COG2972	Histidine kinase
HZF06_RS18625	COG0745	RESPONSE REGULATOR receiver
HZF06_RS18660	COG1595	DNA-templated transcription, initiation
HZF06_RS18670	COG2246	polysaccharide biosynthetic process
HZF06_RS18680	COG0463	Glycosyl transferase, family 2
HZF06_RS18685	COG4193	domain, Protein
HZF06_RS18725	COG2445	Protein of unknown function DUF86
HZF06_RS18730	COG1316	TRANSCRIPTIONal
HZF06_RS18775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZF06_RS18780	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HZF06_RS18790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZF06_RS18795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZF06_RS18810	COG0489	protein tyrosine kinase activity
HZF06_RS18815	COG3944	biosynthesis protein
HZF06_RS18820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZF06_RS18825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZF06_RS18855	COG1216	Glycosyl transferase, family 2
HZF06_RS18855	COG0463	Glycosyl transferase, family 2
HZF06_RS18870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZF06_RS18880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZF06_RS18885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZF06_RS18890	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HZF06_RS18905	COG3754	Rhamnan synthesis protein F
HZF06_RS18925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZF06_RS18935	COG0463	Glycosyl transferase, family 2
HZF06_RS18950	COG1216	Glycosyl transferase, family 2
HZF06_RS18975	COG1091	dTDP-4-dehydrorhamnose reductase activity
HZF06_RS18985	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HZF06_RS18995	COG3394	polysaccharide catabolic process
HZF06_RS19010	COG2070	2-Nitropropane dioxygenase
HZF06_RS19015	COG3706	GGDEF domain
HZF06_RS19040	COG0802	atpase or kinase
HZF06_RS19045	COG1214	PFAM Peptidase M22, glycoprotease
HZF06_RS19050	COG0456	acetyltransferase
HZF06_RS19060	COG2183	response to ionizing radiation
HZF06_RS19080	COG0277	FAD linked oxidase domain protein
HZF06_RS19085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZF06_RS19090	COG2086	electron transfer activity
HZF06_RS19095	COG1620	l-lactate permease
HZF06_RS19115	COG1307	EDD domain protein, DegV family
HZF06_RS19185	COG3953	SLT domain
HZF06_RS19185	COG5280	Phage tail tape measure protein TP901
HZF06_RS19265	COG3728	DNA packaging
HZF06_RS19265	COG5484	DNA packaging
HZF06_RS19295	COG0629	single-stranded DNA binding
HZF06_RS19370	COG0582	viral genome integration into host DNA
HZF06_RS19385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZF06_RS19455	COG1609	Transcriptional regulator
HZF06_RS19465	COG2385	sporulation resulting in formation of a cellular spore
HZF06_RS19505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZF06_RS19515	COG0356	it plays a direct role in the translocation of protons across the membrane
HZF06_RS19525	COG0183	Belongs to the thiolase family
HZF06_RS19530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HZF06_RS19540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZF06_RS19545	COG0698	ribose 5-phosphate isomerase
HZF06_RS19550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZF06_RS19555	COG0009	L-threonylcarbamoyladenylate synthase
HZF06_RS19565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZF06_RS19570	COG2890	protein-(glutamine-N5) methyltransferase activity
HZF06_RS19585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZF06_RS19590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZF06_RS19615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZF06_RS19635	COG4466	Protein conserved in bacteria
HZF06_RS19640	COG4466	Protein conserved in bacteria
HZF06_RS19670	COG0510	thiamine kinase activity
HZF06_RS19695	COG0583	DNA-binding transcription factor activity
HZF06_RS19700	COG0142	geranyltranstransferase activity
HZF06_RS19715	COG1252	NADH dehydrogenase
HZF06_RS19750	COG2971	BadF BadG BcrA BcrD
HZF06_RS19755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZF06_RS19765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZF06_RS19775	COG2755	lipolytic protein G-D-S-L family
HZF06_RS19805	COG5002	protein histidine kinase activity
HZF06_RS19810	COG0745	RESPONSE REGULATOR receiver
HZF06_RS19970	COG4166	transmembrane transport
HZF06_RS19985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZF06_RS19995	COG4496	protein, YerC YecD
HZF06_RS20000	COG1187	pseudouridine synthase activity
HZF06_RS20010	COG0741	lytic transglycosylase activity
HZF06_RS20030	COG0166	Belongs to the GPI family
HZF06_RS20035	COG2703	oxygen carrier activity
HZF06_RS20040	COG5599	Phosphatase
HZF06_RS20045	COG3757	hydrolase, family 25
HZF06_RS20045	COG3409	Peptidoglycan-binding domain 1 protein
HZF06_RS20080	COG3299	homolog of phage Mu protein gp47
HZF06_RS20100	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZF06_RS20100	COG1388	LysM domain
HZF06_RS20145	COG1396	sequence-specific DNA binding
HZF06_RS20185	COG3711	transcriptional antiterminator
HZF06_RS20190	COG2190	(PTS) system
HZF06_RS20190	COG1263	PTS System
HZF06_RS20190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS20195	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS20205	COG0517	IMP dehydrogenase activity
HZF06_RS20205	COG0516	GMP reductase activity
HZF06_RS20235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZF06_RS20250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZF06_RS20280	COG0398	Pfam SNARE associated Golgi protein
HZF06_RS20290	COG1403	HNH endonuclease
HZF06_RS20300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZF06_RS20300	COG2169	Transcriptional regulator
HZF06_RS20305	COG0493	'glutamate synthase
HZF06_RS20305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZF06_RS20320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZF06_RS20330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS20335	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS20340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS20345	COG3394	polysaccharide catabolic process
HZF06_RS20355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZF06_RS20370	COG3829	transcription factor binding
HZF06_RS20370	COG3290	protein histidine kinase activity
HZF06_RS20375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZF06_RS20385	COG2086	electron transfer activity
HZF06_RS20390	COG1960	acyl-CoA dehydrogenase activity
HZF06_RS20395	COG1024	Enoyl-CoA hydratase
HZF06_RS20405	COG1528	Iron-storage protein
HZF06_RS20410	COG1132	(ABC) transporter
HZF06_RS20430	COG1253	flavin adenine dinucleotide binding
HZF06_RS20435	COG1811	Na channel or pump
HZF06_RS20450	COG1472	Belongs to the glycosyl hydrolase 3 family
HZF06_RS20460	COG2972	Histidine kinase
HZF06_RS20465	COG2207	Transcriptional regulator
HZF06_RS20465	COG4753	response regulator
HZF06_RS20475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HZF06_RS20475	COG0662	Cupin 2, conserved barrel domain protein
HZF06_RS20485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZF06_RS20500	COG1131	(ABC) transporter
HZF06_RS20505	COG2197	response regulator
HZF06_RS20510	COG4585	Histidine kinase
HZF06_RS20520	COG0726	polysaccharide deacetylase
HZF06_RS20535	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS20540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS20550	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS20610	COG0460	homoserine dehydrogenase
HZF06_RS20615	COG2222	sugar isomerase
HZF06_RS20620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZF06_RS20665	COG1063	alcohol dehydrogenase
HZF06_RS20670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZF06_RS20680	COG0028	Belongs to the TPP enzyme family
HZF06_RS20700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZF06_RS20705	COG1882	Formate acetyltransferase
HZF06_RS20710	COG0534	Mate efflux family protein
HZF06_RS20745	COG2807	transmembrane transport
HZF06_RS20805	COG2217	Heavy metal translocating P-type atpase
HZF06_RS20810	COG1937	Protein conserved in bacteria
HZF06_RS20820	COG5002	protein histidine kinase activity
HZF06_RS20825	COG0745	RESPONSE REGULATOR receiver
HZF06_RS20835	COG0745	RESPONSE REGULATOR receiver
HZF06_RS20840	COG2205	protein histidine kinase activity
HZF06_RS20845	COG0840	transmembrane signaling receptor activity
HZF06_RS20865	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZF06_RS20920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZF06_RS20925	COG0028	Belongs to the TPP enzyme family
HZF06_RS20935	COG0473	3-isopropylmalate dehydrogenase activity
HZF06_RS20940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZF06_RS20945	COG0440	acetolactate synthase activity
HZF06_RS20950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZF06_RS20965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HZF06_RS20970	COG1131	(ABC) transporter
HZF06_RS20980	COG3426	butyrate kinase activity
HZF06_RS20985	COG0280	phosphate acetyltransferase
HZF06_RS20990	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZF06_RS21000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZF06_RS21015	COG0492	ferredoxin-NADP+ reductase activity
HZF06_RS21025	COG1228	amidohydrolase
HZF06_RS21035	COG0460	homoserine dehydrogenase
HZF06_RS21040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZF06_RS21045	COG3829	transcription factor binding
HZF06_RS21045	COG3290	protein histidine kinase activity
HZF06_RS21065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZF06_RS21070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZF06_RS21075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZF06_RS21090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZF06_RS21130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZF06_RS21135	COG1122	ATPase activity
HZF06_RS21160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZF06_RS21165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZF06_RS21170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZF06_RS21175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZF06_RS21195	COG0201	protein transport
HZF06_RS21205	COG1841	ribosomal large subunit assembly
HZF06_RS21225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZF06_RS21230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZF06_RS21235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZF06_RS21240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZF06_RS21250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZF06_RS21255	COG0255	Belongs to the universal ribosomal protein uL29 family
HZF06_RS21270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZF06_RS21285	COG0089	rRNA binding
HZF06_RS21290	COG0088	Forms part of the polypeptide exit tunnel
HZF06_RS21295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZF06_RS21305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZF06_RS21310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZF06_RS21320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZF06_RS21325	COG1358	cellular component organization or biogenesis
HZF06_RS21365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZF06_RS21370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZF06_RS21375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZF06_RS21395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZF06_RS21410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZF06_RS21415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZF06_RS21420	COG4956	integral membrane protein (PIN domain superfamily)
HZF06_RS21435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HZF06_RS21445	COG2188	Transcriptional regulator
HZF06_RS21460	COG1012	belongs to the aldehyde dehydrogenase family
HZF06_RS21475	COG0542	response to heat
HZF06_RS21480	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HZF06_RS21490	COG4463	regulation of RNA biosynthetic process
HZF06_RS21495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZF06_RS21510	COG1774	PSP1 C-terminal conserved region
HZF06_RS21520	COG3870	Protein conserved in bacteria
HZF06_RS21525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZF06_RS21530	COG1982	Orn Lys Arg decarboxylase major
HZF06_RS21545	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZF06_RS21590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZF06_RS21595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZF06_RS21600	COG0423	glycine-tRNA ligase activity
HZF06_RS21615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZF06_RS21625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZF06_RS21635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HZF06_RS21640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZF06_RS21650	COG0037	tRNA processing
HZF06_RS21705	COG1098	S1 RNA binding domain
HZF06_RS21725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZF06_RS21735	COG3956	TIGRFAM MazG family protein
HZF06_RS21740	COG2244	polysaccharide biosynthetic process
HZF06_RS21745	COG2002	toxin-antitoxin pair type II binding
HZF06_RS21755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZF06_RS21760	COG0193	aminoacyl-tRNA hydrolase activity
HZF06_RS21765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZF06_RS21770	COG3850	Histidine kinase
HZF06_RS21770	COG5002	protein histidine kinase activity
HZF06_RS21775	COG0745	RESPONSE REGULATOR receiver
HZF06_RS21785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZF06_RS21790	COG2088	sporulation resulting in formation of a cellular spore
HZF06_RS21795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZF06_RS21800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZF06_RS21815	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZF06_RS21820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZF06_RS21850	COG0561	phosphatase activity
HZF06_RS21870	COG4608	Belongs to the ABC transporter superfamily
HZF06_RS21875	COG0444	Belongs to the ABC transporter superfamily
HZF06_RS21890	COG0602	queuosine metabolic process
HZF06_RS21905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZF06_RS21910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZF06_RS21915	COG1328	CTP reductase activity
HZF06_RS21920	COG1470	cell adhesion involved in biofilm formation
HZF06_RS21940	COG1141	Ferredoxin
HZF06_RS21975	COG3583	domain protein
HZF06_RS21975	COG3584	3D domain protein
HZF06_RS21980	COG0084	hydrolase, TatD family'
HZF06_RS21985	COG4399	Belongs to the UPF0754 family
HZF06_RS21990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZF06_RS21995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZF06_RS22010	COG0840	transmembrane signaling receptor activity
HZF06_RS22110	COG3279	Response regulator of the LytR AlgR family
HZF06_RS22120	COG0789	Transcriptional regulator
HZF06_RS22120	COG4978	Transcriptional regulator
HZF06_RS22135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZF06_RS22160	COG0006	proline dipeptidase activity
HZF06_RS22170	COG0534	Mate efflux family protein
HZF06_RS22185	COG1131	(ABC) transporter
HZF06_RS22190	COG0700	Nucleoside recognition
HZF06_RS22195	COG2715	membrane protein required for spore maturation
HZF06_RS22215	COG0733	neurotransmitter:sodium symporter activity
HZF06_RS22270	COG1242	4 iron, 4 sulfur cluster binding
HZF06_RS22280	COG3949	Membrane
HZF06_RS22305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZF06_RS22315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZF06_RS22330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZF06_RS22350	COG1668	transmembrane transport
HZF06_RS22355	COG4555	ABC transporter
HZF06_RS22360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HZF06_RS22365	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS22375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZF06_RS22390	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS22400	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HZF06_RS22405	COG0251	oxidation-reduction process
HZF06_RS22440	COG3584	3D domain protein
HZF06_RS22440	COG3583	domain protein
HZF06_RS22450	COG1126	abc transporter atp-binding protein
HZF06_RS22455	COG0765	amino acid transport
HZF06_RS22460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZF06_RS22470	COG0531	amino acid
HZF06_RS22515	COG1086	Polysaccharide biosynthesis protein
HZF06_RS22520	COG2089	acid synthase
HZF06_RS22530	COG2030	dehydratase
HZF06_RS22535	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HZF06_RS22550	COG2211	Major facilitator Superfamily
HZF06_RS22565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZF06_RS22585	COG0493	'glutamate synthase
HZF06_RS22595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZF06_RS22610	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HZF06_RS22625	COG1131	(ABC) transporter
HZF06_RS22630	COG1725	Transcriptional regulator
HZF06_RS22635	COG1486	melibiose metabolic process
HZF06_RS22640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS22650	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS22655	COG0561	phosphatase activity
HZF06_RS22660	COG0488	(ABC) transporter
HZF06_RS22690	COG3711	transcriptional antiterminator
HZF06_RS22690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZF06_RS22700	COG1132	(ABC) transporter
HZF06_RS22710	COG1846	Transcriptional regulator
HZF06_RS22715	COG5002	protein histidine kinase activity
HZF06_RS22720	COG0745	RESPONSE REGULATOR receiver
HZF06_RS22725	COG0840	transmembrane signaling receptor activity
HZF06_RS22730	COG3384	dioxygenase
HZF06_RS22735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZF06_RS22775	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HZF06_RS22795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZF06_RS22810	COG0596	Alpha beta hydrolase
HZF06_RS22810	COG2945	thiolester hydrolase activity
HZF06_RS22830	COG0745	RESPONSE REGULATOR receiver
HZF06_RS22835	COG2205	protein histidine kinase activity
HZF06_RS22840	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZF06_RS22850	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZF06_RS22880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZF06_RS22885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZF06_RS22885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZF06_RS22915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZF06_RS22920	COG2706	6-phosphogluconolactonase activity
HZF06_RS22925	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZF06_RS22925	COG1902	pentaerythritol trinitrate reductase activity
HZF06_RS22940	COG3428	Bacterial PH domain
HZF06_RS22950	COG2223	nitrite transmembrane transporter activity
HZF06_RS22965	COG1473	amidohydrolase
HZF06_RS22970	COG4822	anaerobic cobalamin biosynthetic process
HZF06_RS22980	COG0113	porphobilinogen synthase activity
HZF06_RS22990	COG0181	hydroxymethylbilane synthase activity
HZF06_RS23000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZF06_RS23010	COG1263	PTS System
HZF06_RS23010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS23015	COG3711	transcriptional antiterminator
HZF06_RS23020	COG2190	(PTS) system
HZF06_RS23040	COG2116	formate transmembrane transporter activity
HZF06_RS23055	COG2199	diguanylate cyclase activity
HZF06_RS23055	COG2200	EAL domain
HZF06_RS23060	COG0531	amino acid
HZF06_RS23100	COG0346	lactoylglutathione lyase activity
HZF06_RS23105	COG0028	Belongs to the TPP enzyme family
HZF06_RS23110	COG0440	acetolactate synthase activity
HZF06_RS23115	COG5002	protein histidine kinase activity
HZF06_RS23130	COG0789	Transcriptional regulator
HZF06_RS23145	COG1028	Short-chain dehydrogenase reductase Sdr
HZF06_RS23150	COG0426	domain, Protein
HZF06_RS23160	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS23170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS23180	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS23185	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS23185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS23200	COG2723	6-phospho-beta-galactosidase activity
HZF06_RS23205	COG1312	Catalyzes the dehydration of D-mannonate
HZF06_RS23210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZF06_RS23215	COG0129	dihydroxy-acid dehydratase activity
HZF06_RS23225	COG0800	Aldolase
HZF06_RS23230	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZF06_RS23235	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZF06_RS23235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZF06_RS23240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZF06_RS23245	COG1846	Transcriptional regulator
HZF06_RS23250	COG0386	Belongs to the glutathione peroxidase family
HZF06_RS23260	COG5002	protein histidine kinase activity
HZF06_RS23265	COG0745	RESPONSE REGULATOR receiver
HZF06_RS23270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZF06_RS23275	COG0778	Nitroreductase
HZF06_RS23280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZF06_RS23280	COG0493	'glutamate synthase
HZF06_RS23290	COG1063	alcohol dehydrogenase
HZF06_RS23300	COG1193	negative regulation of DNA recombination
HZF06_RS23305	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HZF06_RS23315	COG4932	domain protein
HZF06_RS23315	COG1388	LysM domain
HZF06_RS23325	COG1191	sigma factor activity
HZF06_RS23330	COG1388	LysM domain
HZF06_RS23330	COG4932	domain protein
HZF06_RS23345	COG1592	Rubrerythrin
HZF06_RS23355	COG0783	Belongs to the Dps family
HZF06_RS23360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZF06_RS23365	COG0488	(ABC) transporter
HZF06_RS23395	COG1704	LemA family
HZF06_RS23410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZF06_RS23425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZF06_RS23455	COG1929	Belongs to the glycerate kinase type-1 family
HZF06_RS23460	COG2190	(PTS) system
HZF06_RS23465	COG1486	melibiose metabolic process
HZF06_RS23470	COG1263	PTS System
HZF06_RS23470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZF06_RS23475	COG1737	Transcriptional regulator
HZF06_RS23505	COG1595	DNA-templated transcription, initiation
HZF06_RS23525	COG0745	RESPONSE REGULATOR receiver
HZF06_RS23530	COG2205	protein histidine kinase activity
HZF06_RS23535	COG0826	peptidase U32
HZF06_RS23540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZF06_RS23545	COG0109	protoheme IX farnesyltransferase activity
HZF06_RS23545	COG1612	heme a metabolic process
HZF06_RS23560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZF06_RS23580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZF06_RS23585	COG5566	PFAM Mor transcription activator
HZF06_RS23595	COG1595	DNA-templated transcription, initiation
HZF06_RS23605	COG1695	Transcriptional regulator
HZF06_RS23610	COG2271	Major facilitator Superfamily
HZF06_RS23615	COG0840	transmembrane signaling receptor activity
HZF06_RS23630	COG0656	L-ascorbic acid biosynthetic process
HZF06_RS23635	COG0640	Transcriptional regulator
HZF06_RS23665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZF06_RS23675	COG2814	Major facilitator Superfamily
HZF06_RS23680	COG0626	cystathionine gamma-synthase activity
HZF06_RS23685	COG0626	cystathionine gamma-synthase activity
HZF06_RS23690	COG0653	protein targeting
HZF06_RS23700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZF06_RS23730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZF06_RS23735	COG1404	Belongs to the peptidase S8 family
HZF06_RS23740	COG0739	heme binding
HZF06_RS23815	COG2081	HI0933 family
HZF06_RS23840	COG0281	malic enzyme
HZF06_RS23855	COG4753	response regulator
HZF06_RS23855	COG2207	Transcriptional regulator
HZF06_RS23860	COG2972	Histidine kinase
HZF06_RS23865	COG1285	pathogenesis
HZF06_RS23880	COG1840	ABC-type Fe3 transport system, periplasmic component
HZF06_RS23885	COG0305	Participates in initiation and elongation during chromosome replication
HZF06_RS23890	COG1067	ATP-dependent peptidase activity
HZF06_RS23890	COG0470	DNA polymerase III
HZF06_RS23900	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HZF06_RS23910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZF06_RS23915	COG0629	single-stranded DNA binding
HZF06_RS23930	COG0668	transmembrane transport
HZF06_RS23935	COG0628	permease
HZF06_RS23955	COG1475	DNA binding
HZF06_RS23960	COG1192	Involved in chromosome partitioning
HZF06_RS23965	COG1475	DNA binding
HZF06_RS23970	COG0357	Ribosomal RNA small subunit methyltransferase G
HZF06_RS23980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZF06_RS23985	COG1847	R3H domain protein
HZF06_RS23995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZF06_RS24000	COG0594	ribonuclease P activity
HZF06_RS24005	COG0230	Belongs to the bacterial ribosomal protein bL34 family