locus-tag	class	description
FORC25_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC25_RS00010	COG0592	DNA-directed DNA polymerase activity
FORC25_RS00030	COG0187	DNA topoisomerase II activity
FORC25_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC25_RS00065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC25_RS00070	COG1615	UPF0182 protein
FORC25_RS00075	COG0579	oxidoreductase
FORC25_RS00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC25_RS00130	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FORC25_RS00145	COG3481	metal-dependent phosphohydrolase, HD sub domain
FORC25_RS00150	COG1376	ErfK ybiS ycfS ynhG family protein
FORC25_RS00190	COG4536	flavin adenine dinucleotide binding
FORC25_RS00195	COG0590	tRNA wobble adenosine to inosine editing
FORC25_RS00225	COG0523	cobalamin synthesis protein
FORC25_RS00230	COG0523	cobalamin synthesis protein
FORC25_RS00235	COG0701	Predicted permease
FORC25_RS00265	COG1114	Component of the transport system for branched-chain amino acids
FORC25_RS00270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC25_RS00275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FORC25_RS00320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC25_RS00330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC25_RS00335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC25_RS00350	COG1428	Deoxynucleoside kinase
FORC25_RS00375	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC25_RS00390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC25_RS00425	COG0531	amino acid
FORC25_RS00440	COG0058	SHG alpha-glucan phosphorylase activity
FORC25_RS00460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC25_RS00470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC25_RS00475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC25_RS00500	COG3711	transcriptional antiterminator
FORC25_RS00510	COG2190	(PTS) system
FORC25_RS00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC25_RS00510	COG1263	PTS System
FORC25_RS00515	COG1309	transcriptional regulator
FORC25_RS00540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC25_RS00550	COG1940	carbohydrate kinase activity
FORC25_RS00555	COG1592	Rubrerythrin
FORC25_RS00555	COG1773	rubredoxin
FORC25_RS00560	COG0406	alpha-ribazole phosphatase activity
FORC25_RS00565	COG1349	DNA-binding transcription factor activity
FORC25_RS00575	COG0191	fructose-bisphosphate aldolase activity
FORC25_RS00580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC25_RS00590	COG3962	Belongs to the TPP enzyme family
FORC25_RS00595	COG0673	inositol 2-dehydrogenase activity
FORC25_RS00600	COG1082	Xylose isomerase domain protein TIM barrel
FORC25_RS00605	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC25_RS00610	COG0673	inositol 2-dehydrogenase activity
FORC25_RS00615	COG2116	formate transmembrane transporter activity
FORC25_RS00620	COG1024	Enoyl-CoA hydratase
FORC25_RS00625	COG4670	ketone body catabolic process
FORC25_RS00630	COG1960	acyl-CoA dehydrogenase activity
FORC25_RS00645	COG2376	Dihydroxyacetone kinase
FORC25_RS00650	COG2814	Major facilitator Superfamily
FORC25_RS00660	COG0039	L-malate dehydrogenase activity
FORC25_RS00695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC25_RS00705	COG4086	secreted protein
FORC25_RS00740	COG0745	RESPONSE REGULATOR receiver
FORC25_RS00745	COG2205	protein histidine kinase activity
FORC25_RS00755	COG1136	(ABC) transporter
FORC25_RS00815	COG0488	(ABC) transporter
FORC25_RS00820	COG3655	Transcriptional regulator
FORC25_RS00865	COG3250	beta-galactosidase activity
FORC25_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
FORC25_RS00895	COG2211	Major facilitator Superfamily
FORC25_RS00960	COG0531	amino acid
FORC25_RS00965	COG1874	Beta-galactosidase
FORC25_RS00970	COG2235	arginine
FORC25_RS01010	COG0626	cystathionine gamma-synthase activity
FORC25_RS01015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC25_RS01040	COG1131	(ABC) transporter
FORC25_RS01045	COG0778	Nitroreductase
FORC25_RS01050	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FORC25_RS01055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC25_RS01060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC25_RS01065	COG2731	YhcH YjgK YiaL family protein
FORC25_RS01090	COG0310	cobalt ion transport
FORC25_RS01100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FORC25_RS01105	COG1122	ATPase activity
FORC25_RS01115	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FORC25_RS01120	COG0739	heme binding
FORC25_RS01195	COG0668	transmembrane transport
FORC25_RS01200	COG5398	heme oxygenase
FORC25_RS01205	COG0420	3'-5' exonuclease activity
FORC25_RS01210	COG0419	ATPase involved in DNA repair
FORC25_RS01220	COG2169	Transcriptional regulator
FORC25_RS01250	COG1120	ATPase activity
FORC25_RS01255	COG4988	ABC transporter
FORC25_RS01260	COG1132	(ABC) transporter
FORC25_RS01265	COG2832	Protein of unknown function (DUF454)
FORC25_RS01285	COG2271	Major facilitator Superfamily
FORC25_RS01290	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC25_RS01300	COG5002	protein histidine kinase activity
FORC25_RS01305	COG0745	RESPONSE REGULATOR receiver
FORC25_RS01310	COG0475	glutathione-regulated potassium exporter activity
FORC25_RS01370	COG2199	diguanylate cyclase activity
FORC25_RS01370	COG2200	EAL domain
FORC25_RS01370	COG2202	Pas domain
FORC25_RS01375	COG0484	heat shock protein binding
FORC25_RS01385	COG0443	Heat shock 70 kDa protein
FORC25_RS01435	COG0110	maltose O-acetyltransferase activity
FORC25_RS01445	COG0668	transmembrane transport
FORC25_RS01450	COG3142	Participates in the control of copper homeostasis
FORC25_RS01470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC25_RS01475	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC25_RS01500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC25_RS01505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC25_RS01520	COG0438	transferase activity, transferring glycosyl groups
FORC25_RS01525	COG0438	transferase activity, transferring glycosyl groups
FORC25_RS01565	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC25_RS01570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC25_RS01575	COG2002	toxin-antitoxin pair type II binding
FORC25_RS01595	COG1295	ribonuclease BN
FORC25_RS01600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC25_RS01605	COG0629	single-stranded DNA binding
FORC25_RS01610	COG0426	domain, Protein
FORC25_RS01625	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC25_RS01630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC25_RS01630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC25_RS01650	COG3959	Transketolase, thiamine diphosphate binding domain
FORC25_RS01655	COG3958	Transketolase
FORC25_RS01660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC25_RS01665	COG2884	Cell division ATP-binding protein ftsE
FORC25_RS01670	COG2177	Part of the ABC transporter FtsEX involved in
FORC25_RS01675	COG0793	Belongs to the peptidase S41A family
FORC25_RS01675	COG3409	Peptidoglycan-binding domain 1 protein
FORC25_RS01695	COG4555	ABC transporter
FORC25_RS01705	COG2755	lipolytic protein G-D-S-L family
FORC25_RS01705	COG0657	acetylesterase activity
FORC25_RS01715	COG2186	Transcriptional regulator
FORC25_RS01720	COG1620	l-lactate permease
FORC25_RS01725	COG2086	electron transfer activity
FORC25_RS01735	COG0277	FAD linked oxidase domain protein
FORC25_RS01750	COG1349	DNA-binding transcription factor activity
FORC25_RS01755	COG1070	Carbohydrate kinase
FORC25_RS01775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC25_RS01780	COG3715	PTS system
FORC25_RS01785	COG3716	PTS system mannose fructose sorbose family IID component
FORC25_RS01820	COG2205	protein histidine kinase activity
FORC25_RS01835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FORC25_RS01865	COG0312	modulator of DNA gyrase
FORC25_RS01870	COG0312	modulator of DNA gyrase
FORC25_RS01880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC25_RS01885	COG0514	ATP-dependent DNA helicase (RecQ)
FORC25_RS01890	COG1834	amidinotransferase
FORC25_RS01895	COG0534	Mate efflux family protein
FORC25_RS01900	COG0789	Transcriptional regulator
FORC25_RS01915	COG1716	ATPase activity
FORC25_RS01925	COG0768	penicillin binding
FORC25_RS01930	COG0322	excinuclease ABC activity
FORC25_RS01935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC25_RS01945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC25_RS01965	COG1595	DNA-templated transcription, initiation
FORC25_RS01990	COG0469	pyruvate kinase activity
FORC25_RS02000	COG0300	oxidoreductase activity
FORC25_RS02005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC25_RS02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC25_RS02065	COG4716	Myosin-crossreactive antigen
FORC25_RS02075	COG1132	(ABC) transporter
FORC25_RS02100	COG0726	polysaccharide deacetylase
FORC25_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
FORC25_RS02110	COG1802	Transcriptional regulator
FORC25_RS02115	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC25_RS02120	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC25_RS02135	COG1408	metallophosphoesterase
FORC25_RS02140	COG2084	Dehydrogenase
FORC25_RS02145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC25_RS02155	COG0157	Belongs to the NadC ModD family
FORC25_RS02165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC25_RS02170	COG3201	nicotinamide mononucleotide transporter
FORC25_RS02195	COG1114	Component of the transport system for branched-chain amino acids
FORC25_RS02200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC25_RS02205	COG0277	FAD linked oxidase domain protein
FORC25_RS02215	COG0561	phosphatase activity
FORC25_RS02220	COG0579	oxidoreductase
FORC25_RS02225	COG2081	HI0933 family
FORC25_RS02235	COG0288	reversible hydration of carbon dioxide
FORC25_RS02250	COG0326	Molecular chaperone. Has ATPase activity
FORC25_RS02255	COG1609	Transcriptional regulator
FORC25_RS02260	COG0366	Alpha amylase catalytic
FORC25_RS02265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC25_RS02265	COG1263	PTS System
FORC25_RS02265	COG2190	(PTS) system
FORC25_RS02275	COG0584	glycerophosphoryl diester phosphodiesterase
FORC25_RS02280	COG2271	Major facilitator Superfamily
FORC25_RS02325	COG2267	carboxylic ester hydrolase activity
FORC25_RS02350	COG1253	flavin adenine dinucleotide binding
FORC25_RS02355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC25_RS02365	COG0346	lactoylglutathione lyase activity
FORC25_RS02375	COG1454	alcohol dehydrogenase
FORC25_RS02385	COG0346	lactoylglutathione lyase activity
FORC25_RS02390	COG0789	Transcriptional regulator
FORC25_RS02415	COG5002	protein histidine kinase activity
FORC25_RS02430	COG3944	biosynthesis protein
FORC25_RS02435	COG0489	protein tyrosine kinase activity
FORC25_RS02440	COG1086	Polysaccharide biosynthesis protein
FORC25_RS02445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC25_RS02450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC25_RS02460	COG0438	transferase activity, transferring glycosyl groups
FORC25_RS02475	COG0438	transferase activity, transferring glycosyl groups
FORC25_RS02495	COG0438	transferase activity, transferring glycosyl groups
FORC25_RS02495	COG0297	glycogen (starch) synthase activity
FORC25_RS02505	COG1316	TRANSCRIPTIONal
FORC25_RS02510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FORC25_RS02525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC25_RS02530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FORC25_RS02550	COG4509	Sortase family
FORC25_RS02580	COG3279	Response regulator of the LytR AlgR family
FORC25_RS02595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC25_RS02610	COG0561	phosphatase activity
FORC25_RS02615	COG1846	Transcriptional regulator
FORC25_RS02625	COG1132	(ABC) transporter
FORC25_RS02640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC25_RS02645	COG3290	protein histidine kinase activity
FORC25_RS02650	COG4565	transcriptional regulatory protein
FORC25_RS02680	COG1454	alcohol dehydrogenase
FORC25_RS02700	COG0628	permease
FORC25_RS02705	COG3104	oligopeptide transport
FORC25_RS02720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC25_RS02725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FORC25_RS02730	COG1982	Orn Lys Arg decarboxylase major
FORC25_RS02740	COG0010	Belongs to the arginase family
FORC25_RS02745	COG3326	Membrane
FORC25_RS02760	COG2217	Heavy metal translocating P-type atpase
FORC25_RS02775	COG1174	glycine betaine transport
FORC25_RS02780	COG1595	DNA-templated transcription, initiation
FORC25_RS02790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC25_RS02790	COG1263	PTS System
FORC25_RS02795	COG0366	Alpha amylase catalytic
FORC25_RS02800	COG2188	Transcriptional regulator
FORC25_RS02805	COG0768	penicillin binding
FORC25_RS02825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC25_RS02825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC25_RS02835	COG0432	Pfam Uncharacterised protein family UPF0047
FORC25_RS02845	COG5426	von Willebrand factor, type A
FORC25_RS02850	COG2972	Histidine kinase
FORC25_RS02855	COG2207	Transcriptional regulator
FORC25_RS02855	COG4753	response regulator
FORC25_RS02865	COG1175	transmembrane transport
FORC25_RS02870	COG0395	ABC-type sugar transport system, permease component
FORC25_RS02875	COG0398	Pfam SNARE associated Golgi protein
FORC25_RS02885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC25_RS02895	COG0306	phosphate transporter
FORC25_RS02900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC25_RS02900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC25_RS02900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC25_RS02905	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC25_RS02910	COG1349	DNA-binding transcription factor activity
FORC25_RS02920	COG0628	permease
FORC25_RS02930	COG0038	chloride channel
FORC25_RS02940	COG1285	pathogenesis
FORC25_RS02965	COG1489	DNA binding
FORC25_RS02970	COG2816	NAD+ diphosphatase activity
FORC25_RS02975	COG0019	diaminopimelate decarboxylase activity
FORC25_RS02990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC25_RS02995	COG3973	AAA domain
FORC25_RS03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC25_RS03005	COG0765	amino acid transport
FORC25_RS03010	COG1126	abc transporter atp-binding protein
FORC25_RS03015	COG1368	sulfuric ester hydrolase activity
FORC25_RS03020	COG1368	sulfuric ester hydrolase activity
FORC25_RS03025	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FORC25_RS03030	COG1362	aminopeptidase activity
FORC25_RS03045	COG0561	phosphatase activity
FORC25_RS03050	COG1033	growth of symbiont in host cell
FORC25_RS03050	COG2409	Drug exporters of the RND superfamily
FORC25_RS03055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC25_RS03065	COG0561	phosphatase activity
FORC25_RS03090	COG1091	dTDP-4-dehydrorhamnose reductase activity
FORC25_RS03100	COG3754	Rhamnan synthesis protein F
FORC25_RS03105	COG0438	transferase activity, transferring glycosyl groups
FORC25_RS03115	COG3475	LICD family
FORC25_RS03125	COG4193	domain, Protein
FORC25_RS03125	COG5263	repeat protein
FORC25_RS03150	COG4750	Nucleotidyl transferase
FORC25_RS03160	COG1316	TRANSCRIPTIONal
FORC25_RS03165	COG1114	Component of the transport system for branched-chain amino acids
FORC25_RS03180	COG0641	radical SAM
FORC25_RS03185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC25_RS03190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC25_RS03195	COG0573	inorganic phosphate transmembrane transporter activity
FORC25_RS03200	COG0581	inorganic phosphate transmembrane transporter activity
FORC25_RS03210	COG0704	Plays a role in the regulation of phosphate uptake
FORC25_RS03215	COG0745	RESPONSE REGULATOR receiver
FORC25_RS03245	COG0697	spore germination
FORC25_RS03275	COG2357	RelA SpoT domain protein
FORC25_RS03285	COG1126	abc transporter atp-binding protein
FORC25_RS03290	COG3864	Putative metallopeptidase domain
FORC25_RS03335	COG1328	CTP reductase activity
FORC25_RS03340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC25_RS03345	COG1349	DNA-binding transcription factor activity
FORC25_RS03355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC25_RS03450	COG0756	dUTP diphosphatase activity
FORC25_RS03455	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC25_RS03460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC25_RS03465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC25_RS03470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC25_RS03475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC25_RS03480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC25_RS03485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC25_RS03495	COG0151	Belongs to the GarS family
FORC25_RS03510	COG1773	rubredoxin
FORC25_RS03510	COG1592	Rubrerythrin
FORC25_RS03515	COG0165	Argininosuccinate lyase
FORC25_RS03530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FORC25_RS03530	COG3291	Pkd domain containing protein
FORC25_RS03535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FORC25_RS03540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC25_RS03545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC25_RS03550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC25_RS03555	COG0077	Prephenate dehydratase
FORC25_RS03555	COG1605	Chorismate mutase
FORC25_RS03595	COG4152	abc transporter atp-binding protein
FORC25_RS03600	COG1668	transmembrane transport
FORC25_RS03610	COG1522	sequence-specific DNA binding
FORC25_RS03615	COG0436	Aminotransferase
FORC25_RS03630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC25_RS03640	COG1595	DNA-templated transcription, initiation
FORC25_RS03650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC25_RS03655	COG1216	Glycosyl transferase, family 2
FORC25_RS03660	COG0628	permease
FORC25_RS03670	COG1349	DNA-binding transcription factor activity
FORC25_RS03675	COG0561	phosphatase activity
FORC25_RS03680	COG1533	DNA photolyase activity
FORC25_RS03695	COG3620	sequence-specific DNA binding
FORC25_RS03700	COG4221	oxidoreductase activity
FORC25_RS03705	COG0456	acetyltransferase
FORC25_RS03720	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC25_RS03740	COG5566	PFAM Mor transcription activator
FORC25_RS03745	COG3118	belongs to the thioredoxin family
FORC25_RS03755	COG0785	Cytochrome C biogenesis protein
FORC25_RS03760	COG0657	acetylesterase activity
FORC25_RS03775	COG1309	transcriptional regulator
FORC25_RS03805	COG0402	S-adenosylhomocysteine deaminase activity
FORC25_RS03810	COG1402	creatininase
FORC25_RS03815	COG0697	spore germination
FORC25_RS03820	COG2508	Transcriptional regulator
FORC25_RS03830	COG1011	Hydrolase
FORC25_RS03850	COG2211	Major facilitator Superfamily
FORC25_RS03855	COG2207	Transcriptional regulator
FORC25_RS03860	COG3250	beta-galactosidase activity
FORC25_RS03865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC25_RS03865	COG0723	plastoquinol--plastocyanin reductase activity
FORC25_RS03870	COG2610	gluconate transmembrane transporter activity
FORC25_RS03880	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
FORC25_RS03890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC25_RS03930	COG0488	(ABC) transporter
FORC25_RS03940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC25_RS03945	COG1846	Transcriptional regulator
FORC25_RS03955	COG1846	Transcriptional regulator
FORC25_RS03965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC25_RS03970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC25_RS03975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC25_RS03980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC25_RS03985	COG1120	ATPase activity
FORC25_RS03990	COG0494	nUDIX hydrolase
FORC25_RS04025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC25_RS04045	COG3681	Belongs to the UPF0597 family
FORC25_RS04065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC25_RS04070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC25_RS04075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC25_RS04080	COG1120	ATPase activity
FORC25_RS04105	COG3291	Pkd domain containing protein
FORC25_RS04105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FORC25_RS04115	COG0561	phosphatase activity
FORC25_RS04125	COG3715	PTS system
FORC25_RS04130	COG3716	PTS system mannose fructose sorbose family IID component
FORC25_RS04170	COG2340	Cysteine-rich secretory protein family
FORC25_RS04180	COG1132	(ABC) transporter
FORC25_RS04190	COG0534	Mate efflux family protein
FORC25_RS04195	COG0745	RESPONSE REGULATOR receiver
FORC25_RS04200	COG2205	protein histidine kinase activity
FORC25_RS04220	COG1136	(ABC) transporter
FORC25_RS04225	COG0577	efflux transmembrane transporter activity
FORC25_RS04250	COG1592	Rubrerythrin
FORC25_RS04265	COG1979	alcohol dehydrogenase
FORC25_RS04275	COG3835	regulator
FORC25_RS04280	COG2610	gluconate transmembrane transporter activity
FORC25_RS04285	COG1929	Belongs to the glycerate kinase type-1 family
FORC25_RS04300	COG0534	Mate efflux family protein
FORC25_RS04310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FORC25_RS04310	COG3291	Pkd domain containing protein
FORC25_RS04330	COG3290	protein histidine kinase activity
FORC25_RS04340	COG0006	proline dipeptidase activity
FORC25_RS04350	COG2309	aminopeptidase activity
FORC25_RS04360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC25_RS04365	COG3153	acetyltransferase
FORC25_RS04380	COG0393	Putative heavy-metal-binding
FORC25_RS04390	COG1131	(ABC) transporter
FORC25_RS04410	COG0494	nUDIX hydrolase
FORC25_RS04455	COG4303	Ethanolamine ammonia lyase large subunit
FORC25_RS04460	COG4302	ethanolamine ammonia-lyase activity
FORC25_RS04465	COG4816	utilization protein
FORC25_RS04475	COG1012	belongs to the aldehyde dehydrogenase family
FORC25_RS04475	COG1454	alcohol dehydrogenase
FORC25_RS04490	COG4869	propanediol catabolic process
FORC25_RS04500	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
FORC25_RS04510	COG3192	ethanolamine utilization protein
FORC25_RS04520	COG0386	Belongs to the glutathione peroxidase family
FORC25_RS04535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC25_RS04550	COG1328	CTP reductase activity
FORC25_RS04550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC25_RS04675	COG5484	DNA packaging
FORC25_RS04675	COG3728	DNA packaging
FORC25_RS04845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC25_RS04895	COG1266	CAAX protease self-immunity
FORC25_RS04915	COG1401	restriction endodeoxyribonuclease activity
FORC25_RS04945	COG1266	CAAX protease self-immunity
FORC25_RS04965	COG1473	amidohydrolase
FORC25_RS04980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC25_RS04990	COG1695	Transcriptional regulator
FORC25_RS05005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FORC25_RS05075	COG0741	lytic transglycosylase activity
FORC25_RS05075	COG0791	NLP P60 protein
FORC25_RS05125	COG2946	Replication initiation factor
FORC25_RS05135	COG1674	ftsk spoiiie
FORC25_RS05160	COG0210	DNA helicase
FORC25_RS05210	COG0494	nUDIX hydrolase
FORC25_RS05245	COG1609	Transcriptional regulator
FORC25_RS05250	COG1653	transport
FORC25_RS05255	COG1175	transmembrane transport
FORC25_RS05260	COG0395	ABC-type sugar transport system, permease component
FORC25_RS05265	COG3842	ATPase activity
FORC25_RS05270	COG1621	beta-fructofuranosidase activity
FORC25_RS05275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC25_RS05310	COG1201	RNA secondary structure unwinding
FORC25_RS05330	COG0072	phenylalanine-tRNA ligase activity
FORC25_RS05330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC25_RS05345	COG0494	nUDIX hydrolase
FORC25_RS05360	COG1733	regulation of RNA biosynthetic process
FORC25_RS05370	COG0656	L-ascorbic acid biosynthetic process
FORC25_RS05390	COG0745	RESPONSE REGULATOR receiver
FORC25_RS05395	COG5002	protein histidine kinase activity
FORC25_RS05395	COG3850	Histidine kinase
FORC25_RS05400	COG0561	phosphatase activity
FORC25_RS05415	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC25_RS05430	COG3546	catalase activity
FORC25_RS05440	COG1263	PTS System
FORC25_RS05440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC25_RS05475	COG1653	transport
FORC25_RS05510	COG1523	belongs to the glycosyl hydrolase 13 family
FORC25_RS05535	COG1595	DNA-templated transcription, initiation
FORC25_RS05545	COG1131	(ABC) transporter
FORC25_RS05575	COG3119	arylsulfatase activity
FORC25_RS05580	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FORC25_RS05580	COG3976	FMN-binding domain protein
FORC25_RS05620	COG3594	Acyltransferase
FORC25_RS05625	COG2207	Transcriptional regulator
FORC25_RS05630	COG2972	Histidine kinase
FORC25_RS05640	COG1175	transmembrane transport
FORC25_RS05645	COG0395	ABC-type sugar transport system, permease component
FORC25_RS05710	COG1151	hydroxylamine reductase activity
FORC25_RS05760	COG0745	RESPONSE REGULATOR receiver
FORC25_RS05765	COG5002	protein histidine kinase activity
FORC25_RS05785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FORC25_RS05790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC25_RS05800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC25_RS05810	COG1187	pseudouridine synthase activity
FORC25_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
FORC25_RS05830	COG1285	pathogenesis
FORC25_RS05850	COG0586	Pfam SNARE associated Golgi protein
FORC25_RS05875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC25_RS05875	COG2199	diguanylate cyclase activity
FORC25_RS05880	COG0778	Nitroreductase
FORC25_RS05900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC25_RS05905	COG3275	phosphorelay sensor kinase activity
FORC25_RS05910	COG2197	response regulator
FORC25_RS05955	COG0531	amino acid
FORC25_RS05960	COG3976	FMN-binding domain protein
FORC25_RS05960	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FORC25_RS05990	COG2267	carboxylic ester hydrolase activity
FORC25_RS06005	COG1823	symporter activity
FORC25_RS06010	COG0745	RESPONSE REGULATOR receiver
FORC25_RS06025	COG5002	protein histidine kinase activity
FORC25_RS06045	COG2081	HI0933 family
FORC25_RS06055	COG1136	(ABC) transporter
FORC25_RS06065	COG0577	efflux transmembrane transporter activity
FORC25_RS06085	COG1051	belongs to the nudix hydrolase family
FORC25_RS06095	COG1846	Transcriptional regulator
FORC25_RS06100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FORC25_RS06105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FORC25_RS06110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FORC25_RS06115	COG2205	protein histidine kinase activity
FORC25_RS06120	COG0745	RESPONSE REGULATOR receiver
FORC25_RS06135	COG0531	amino acid
FORC25_RS06140	COG2203	Gaf domain
FORC25_RS06140	COG3706	GGDEF domain
FORC25_RS06140	COG5001	Diguanylate cyclase
FORC25_RS06140	COG4251	negative regulation of phosphorylation
FORC25_RS06170	COG3645	SOS response
FORC25_RS06170	COG3646	Phage regulatory protein
FORC25_RS06270	COG1783	phage Terminase large subunit
FORC25_RS06400	COG0475	glutathione-regulated potassium exporter activity
FORC25_RS06400	COG0569	domain protein
FORC25_RS06415	COG2706	6-phosphogluconolactonase activity
FORC25_RS06430	COG3158	transport of potassium into the cell
FORC25_RS06440	COG2207	Transcriptional regulator
FORC25_RS06440	COG1917	Cupin 2, conserved barrel domain protein
FORC25_RS06460	COG0697	spore germination
FORC25_RS06465	COG1288	antiporter activity
FORC25_RS06470	COG0784	Response regulator, receiver
FORC25_RS06470	COG2205	protein histidine kinase activity
FORC25_RS06490	COG0037	tRNA processing
FORC25_RS06500	COG2070	2-Nitropropane dioxygenase
FORC25_RS06505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC25_RS06515	COG1363	Peptidase, m42
FORC25_RS06565	COG0598	Magnesium transport protein CorA
FORC25_RS06570	COG1362	aminopeptidase activity
FORC25_RS06575	COG1716	ATPase activity
FORC25_RS06575	COG5001	Diguanylate cyclase
FORC25_RS06590	COG0251	oxidation-reduction process
FORC25_RS06600	COG0426	domain, Protein
FORC25_RS06605	COG0613	PHP domain protein
FORC25_RS06610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC25_RS06610	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC25_RS06620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC25_RS06625	COG0302	gtp cyclohydrolase
FORC25_RS06635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC25_RS06640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC25_RS06640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC25_RS06660	COG0671	phosphoesterase, PA-phosphatase related
FORC25_RS06665	COG1653	transport
FORC25_RS06670	COG1993	acr, cog1993
FORC25_RS06675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC25_RS06685	COG0640	Transcriptional regulator
FORC25_RS06690	COG1473	amidohydrolase
FORC25_RS06710	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC25_RS06730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC25_RS06735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC25_RS06740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC25_RS06745	COG1120	ATPase activity
FORC25_RS06760	COG1151	hydroxylamine reductase activity
FORC25_RS06770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC25_RS06775	COG2897	thiosulfate sulfurtransferase activity
FORC25_RS06795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC25_RS06805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC25_RS06805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC25_RS06825	COG4659	FMN binding
FORC25_RS06830	COG4660	Part of a membrane complex involved in electron transport
FORC25_RS06835	COG4657	Part of a membrane complex involved in electron transport
FORC25_RS06840	COG2878	Part of a membrane complex involved in electron transport
FORC25_RS06840	COG1245	4Fe-4S binding domain
FORC25_RS06850	COG1846	Transcriptional regulator
FORC25_RS06860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FORC25_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
FORC25_RS06870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC25_RS06875	COG0511	ligase activity, forming carbon-carbon bonds
FORC25_RS06885	COG0439	Biotin carboxylase
FORC25_RS06890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC25_RS06895	COG0825	malonyl-CoA metabolic process
FORC25_RS06915	COG1187	pseudouridine synthase activity
FORC25_RS06920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FORC25_RS06930	COG2081	HI0933 family
FORC25_RS06935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC25_RS06965	COG1396	sequence-specific DNA binding
FORC25_RS07210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC25_RS07215	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC25_RS07285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC25_RS07290	COG1923	regulation of RNA biosynthetic process
FORC25_RS07295	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FORC25_RS07315	COG4974	Belongs to the 'phage' integrase family
FORC25_RS07325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FORC25_RS07360	COG0833	amino acid
FORC25_RS07365	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC25_RS07375	COG2364	Membrane
FORC25_RS07400	COG0708	Exodeoxyribonuclease III
FORC25_RS07420	COG0167	dihydroorotate dehydrogenase activity
FORC25_RS07445	COG0540	Belongs to the ATCase OTCase family
FORC25_RS07460	COG1968	undecaprenyl-diphosphatase activity
FORC25_RS07465	COG1482	cell wall glycoprotein biosynthetic process
FORC25_RS07470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC25_RS07475	COG3442	glutamine amidotransferase
FORC25_RS07550	COG0534	Mate efflux family protein
FORC25_RS07575	COG0564	pseudouridine synthase activity
FORC25_RS07580	COG1473	amidohydrolase
FORC25_RS07585	COG0210	DNA helicase
FORC25_RS07590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC25_RS07600	COG0735	belongs to the Fur family
FORC25_RS07605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC25_RS07610	COG2233	PERMEase
FORC25_RS07615	COG0824	Thioesterase
FORC25_RS07620	COG1120	ATPase activity
FORC25_RS07625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC25_RS07670	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FORC25_RS07685	COG3584	3D domain protein
FORC25_RS07685	COG1388	LysM domain
FORC25_RS07695	COG3103	Sh3 type 3 domain protein
FORC25_RS07710	COG3291	Pkd domain containing protein
FORC25_RS07710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FORC25_RS07730	COG2814	Major facilitator Superfamily
FORC25_RS07735	COG2239	Acts as a magnesium transporter
FORC25_RS07745	COG1278	Cold shock
FORC25_RS07755	COG1376	ErfK ybiS ycfS ynhG family protein
FORC25_RS07765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FORC25_RS07765	COG0392	lysyltransferase activity
FORC25_RS07770	COG0392	lysyltransferase activity
FORC25_RS07770	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FORC25_RS07800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC25_RS07800	COG0493	'glutamate synthase
FORC25_RS07820	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC25_RS07820	COG3103	Sh3 type 3 domain protein
FORC25_RS07820	COG4991	sh3 domain protein
FORC25_RS07885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC25_RS07890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FORC25_RS07890	COG3291	Pkd domain containing protein
FORC25_RS07900	COG3250	beta-galactosidase activity
FORC25_RS07905	COG0402	S-adenosylhomocysteine deaminase activity
FORC25_RS07910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FORC25_RS07925	COG1177	transmembrane transport
FORC25_RS07930	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC25_RS07975	COG2188	Transcriptional regulator
FORC25_RS07980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC25_RS07990	COG1846	Transcriptional regulator
FORC25_RS08005	COG1902	pentaerythritol trinitrate reductase activity
FORC25_RS08005	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC25_RS08015	COG2211	Major facilitator Superfamily
FORC25_RS08045	COG0557	exoribonuclease II activity
FORC25_RS08065	COG0531	amino acid
FORC25_RS08080	COG0126	phosphoglycerate kinase activity
FORC25_RS08085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC25_RS08090	COG2390	Transcriptional regulator
FORC25_RS08095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FORC25_RS08110	COG1744	ABC transporter substrate-binding protein PnrA-like
FORC25_RS08125	COG0561	phosphatase activity
FORC25_RS08130	COG2720	vancomycin resistance protein
FORC25_RS08145	COG5002	protein histidine kinase activity
FORC25_RS08155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC25_RS08165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC25_RS08170	COG1045	serine acetyltransferase
FORC25_RS08175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC25_RS08180	COG2239	Acts as a magnesium transporter
FORC25_RS08185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC25_RS08190	COG0765	amino acid transport
FORC25_RS08205	COG1597	lipid kinase activity
FORC25_RS08210	COG1183	phosphatidylcholine synthase activity
FORC25_RS08225	COG2719	SpoVR family
FORC25_RS08230	COG2718	Belongs to the UPF0229 family
FORC25_RS08235	COG2766	serine protein kinase
FORC25_RS08240	COG0514	ATP-dependent DNA helicase (RecQ)
FORC25_RS08250	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC25_RS08255	COG0351	phosphomethylpyrimidine kinase
FORC25_RS08265	COG1609	Transcriptional regulator
FORC25_RS08275	COG1129	ABC transporter
FORC25_RS08290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC25_RS08295	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FORC25_RS08305	COG2323	membrane
FORC25_RS08335	COG0791	NLP P60 protein
FORC25_RS08335	COG0741	lytic transglycosylase activity
FORC25_RS08350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC25_RS08375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FORC25_RS08375	COG3291	Pkd domain containing protein
FORC25_RS08400	COG0733	neurotransmitter:sodium symporter activity
FORC25_RS08410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC25_RS08440	COG1876	peptidase activity
FORC25_RS08460	COG0024	Methionine aminopeptidase
FORC25_RS08490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC25_RS08495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC25_RS08500	COG0470	DNA polymerase III
FORC25_RS08500	COG1067	ATP-dependent peptidase activity
FORC25_RS08505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC25_RS08515	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC25_RS08570	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC25_RS08585	COG4656	Part of a membrane complex involved in electron transport
FORC25_RS08590	COG4658	electron transport chain
FORC25_RS08600	COG0301	tRNA thio-modification
FORC25_RS08610	COG4492	Belongs to the UPF0735 family
FORC25_RS08615	COG0383	alpha-mannosidase activity
FORC25_RS08620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC25_RS08625	COG0646	methionine synthase
FORC25_RS08625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC25_RS08635	COG1115	amino acid carrier protein
FORC25_RS08645	COG4684	Psort location CytoplasmicMembrane, score
FORC25_RS08650	COG3191	aminopeptidase activity
FORC25_RS08695	COG1053	succinate dehydrogenase
FORC25_RS08700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC25_RS08705	COG0113	porphobilinogen synthase activity
FORC25_RS08765	COG2207	Transcriptional regulator
FORC25_RS08765	COG1917	Cupin 2, conserved barrel domain protein
FORC25_RS08780	COG0328	RNA-DNA hybrid ribonuclease activity
FORC25_RS08790	COG0705	Rhomboid family
FORC25_RS08790	COG0457	Tetratricopeptide repeat
FORC25_RS08795	COG1164	Oligoendopeptidase f
FORC25_RS08810	COG1121	(ABC) transporter
FORC25_RS08815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC25_RS08825	COG0534	Mate efflux family protein
FORC25_RS08840	COG3716	PTS system mannose fructose sorbose family IID component
FORC25_RS08845	COG3715	PTS system
FORC25_RS08860	COG0205	6-phosphofructokinase activity
FORC25_RS08870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC25_RS08875	COG0488	(ABC) transporter
FORC25_RS08880	COG0756	dUTP diphosphatase activity
FORC25_RS08895	COG1272	protein, Hemolysin III
FORC25_RS08900	COG0583	DNA-binding transcription factor activity
FORC25_RS08925	COG0659	secondary active sulfate transmembrane transporter activity
FORC25_RS08930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC25_RS08930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC25_RS08945	COG1116	anion transmembrane transporter activity
FORC25_RS08970	COG0730	response to heat
FORC25_RS08980	COG0586	Pfam SNARE associated Golgi protein
FORC25_RS08990	COG0037	tRNA processing
FORC25_RS09000	COG2848	UPF0210 protein
FORC25_RS09010	COG2333	competence protein COMEC
FORC25_RS09010	COG0658	competence protein
FORC25_RS09020	COG3279	Response regulator of the LytR AlgR family
FORC25_RS09035	COG3584	3D domain protein
FORC25_RS09035	COG3583	domain protein
FORC25_RS09045	COG0488	(ABC) transporter
FORC25_RS09075	COG0745	RESPONSE REGULATOR receiver
FORC25_RS09075	COG2205	protein histidine kinase activity
FORC25_RS09075	COG3292	Two component regulator propeller
FORC25_RS09105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FORC25_RS09115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC25_RS09130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FORC25_RS09130	COG3291	Pkd domain containing protein
FORC25_RS09135	COG5599	Phosphatase
FORC25_RS09140	COG1132	(ABC) transporter
FORC25_RS09145	COG1132	(ABC) transporter
FORC25_RS09165	COG5298	Protein conserved in bacteria
FORC25_RS09175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC25_RS09180	COG1621	beta-fructofuranosidase activity
FORC25_RS09185	COG1609	Transcriptional regulator
FORC25_RS09220	COG0577	efflux transmembrane transporter activity
FORC25_RS09225	COG0577	efflux transmembrane transporter activity
FORC25_RS09225	COG1136	(ABC) transporter
FORC25_RS09250	COG4086	secreted protein
FORC25_RS09255	COG0464	growth
FORC25_RS09260	COG0243	molybdopterin cofactor binding
FORC25_RS09265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC25_RS09280	COG1523	belongs to the glycosyl hydrolase 13 family
FORC25_RS09305	COG4129	membrane
FORC25_RS09310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC25_RS09315	COG1233	COG1233 Phytoene dehydrogenase and related
FORC25_RS09320	COG2199	diguanylate cyclase activity
FORC25_RS09320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC25_RS09355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC25_RS09360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC25_RS09370	COG0561	phosphatase activity
FORC25_RS09400	COG2252	PERMEase
FORC25_RS09410	COG1079	Belongs to the binding-protein-dependent transport system permease family
FORC25_RS09415	COG4603	Belongs to the binding-protein-dependent transport system permease family
FORC25_RS09420	COG3845	ABC transporter
FORC25_RS09425	COG1744	ABC transporter substrate-binding protein PnrA-like
FORC25_RS09445	COG4720	Psort location CytoplasmicMembrane, score
FORC25_RS09450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC25_RS09460	COG1523	belongs to the glycosyl hydrolase 13 family
FORC25_RS09465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC25_RS09490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FORC25_RS09490	COG0392	lysyltransferase activity
FORC25_RS09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC25_RS09500	COG3458	cephalosporin-C deacetylase activity
FORC25_RS09515	COG0352	thiamine-phosphate diphosphorylase activity
FORC25_RS09540	COG2814	Major facilitator Superfamily
FORC25_RS09555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC25_RS09570	COG0726	polysaccharide deacetylase
FORC25_RS09580	COG0398	Pfam SNARE associated Golgi protein
FORC25_RS09590	COG0741	lytic transglycosylase activity
FORC25_RS09590	COG0739	heme binding
FORC25_RS09590	COG1196	nuclear chromosome segregation
FORC25_RS09620	COG3973	AAA domain
FORC25_RS09655	COG1609	Transcriptional regulator
FORC25_RS09660	COG1879	ABC-type sugar transport system periplasmic component
FORC25_RS09665	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC25_RS09670	COG1129	ABC transporter
FORC25_RS09675	COG1869	D-ribose catabolic process
FORC25_RS09690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC25_RS09710	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
FORC25_RS09725	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
FORC25_RS09730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC25_RS09735	COG1269	ATP hydrolysis coupled proton transport
FORC25_RS09760	COG2244	polysaccharide biosynthetic process
FORC25_RS09790	COG1522	sequence-specific DNA binding
FORC25_RS09795	COG2155	Conserved Protein
FORC25_RS09805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FORC25_RS09840	COG1994	Peptidase M50
FORC25_RS09845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC25_RS09865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC25_RS09875	COG2359	stage V sporulation protein S
FORC25_RS09880	COG1418	mRNA catabolic process
FORC25_RS09890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC25_RS09895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC25_RS09905	COG0740	serine-type endopeptidase activity
FORC25_RS09910	COG0527	aspartate kinase activity
FORC25_RS09930	COG0196	riboflavin kinase activity
FORC25_RS09940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FORC25_RS09960	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FORC25_RS09965	COG0195	Participates in both transcription termination and antitermination
FORC25_RS09970	COG0779	Required for maturation of 30S ribosomal subunits
FORC25_RS09995	COG4589	Belongs to the CDS family
FORC25_RS10010	COG0528	UMP kinase activity
FORC25_RS10030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC25_RS10035	COG0758	DNA mediated transformation
FORC25_RS10040	COG0606	chelatase, subunit chli
FORC25_RS10045	COG0792	nuclease activity
FORC25_RS10050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC25_RS10055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC25_RS10060	COG0335	large ribosomal subunit rRNA binding
FORC25_RS10065	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC25_RS10070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC25_RS10085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC25_RS10095	COG0552	protein localization to endoplasmic reticulum
FORC25_RS10140	COG0280	phosphate acetyltransferase
FORC25_RS10165	COG0742	ribosomal rna small subunit methyltransferase
FORC25_RS10170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC25_RS10175	COG1461	Dihydroxyacetone kinase
FORC25_RS10185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC25_RS10195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC25_RS10210	COG0631	protein serine/threonine phosphatase activity
FORC25_RS10215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC25_RS10220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC25_RS10220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC25_RS10225	COG2738	Putative neutral zinc metallopeptidase
FORC25_RS10240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC25_RS10245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC25_RS10255	COG0194	GDP metabolic process
FORC25_RS10265	COG1561	YicC-like family, N-terminal region
FORC25_RS10270	COG2252	PERMEase
FORC25_RS10280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FORC25_RS10285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC25_RS10295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC25_RS10300	COG5002	protein histidine kinase activity
FORC25_RS10305	COG1496	oxidoreductase activity
FORC25_RS10310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC25_RS10315	COG1873	PFAM PRC-barrel domain
FORC25_RS10320	COG1191	sigma factor activity
FORC25_RS10325	COG1191	sigma factor activity
FORC25_RS10340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC25_RS10365	COG0572	uridine kinase
FORC25_RS10370	COG0826	peptidase U32
FORC25_RS10375	COG4122	O-methyltransferase activity
FORC25_RS10380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC25_RS10385	COG1217	gtp-binding protein TYPA
FORC25_RS10390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FORC25_RS10395	COG0735	belongs to the Fur family
FORC25_RS10420	COG0628	permease
FORC25_RS10430	COG0482	sulfurtransferase activity
FORC25_RS10435	COG0822	iron-sulfur transferase activity
FORC25_RS10445	COG1959	2 iron, 2 sulfur cluster binding
FORC25_RS10450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC25_RS10475	COG0746	molybdenum cofactor guanylyltransferase activity
FORC25_RS10500	COG0243	molybdopterin cofactor binding
FORC25_RS10505	COG2081	HI0933 family
FORC25_RS10515	COG1686	Belongs to the peptidase S11 family
FORC25_RS10525	COG3874	Sporulation protein YtfJ
FORC25_RS10535	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FORC25_RS10540	COG1686	Belongs to the peptidase S11 family
FORC25_RS10545	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC25_RS10550	COG4974	Belongs to the 'phage' integrase family
FORC25_RS10560	COG0494	nUDIX hydrolase
FORC25_RS10570	COG0745	RESPONSE REGULATOR receiver
FORC25_RS10575	COG0750	zinc metalloprotease
FORC25_RS10580	COG0497	DNA recombination
FORC25_RS10595	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FORC25_RS10605	COG0142	geranyltranstransferase activity
FORC25_RS10630	COG1302	Protein conserved in bacteria
FORC25_RS10670	COG3854	ATPases associated with a variety of cellular activities
FORC25_RS10725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC25_RS10740	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FORC25_RS10745	COG0116	Belongs to the methyltransferase superfamily
FORC25_RS10755	COG0564	pseudouridine synthase activity
FORC25_RS10760	COG3599	regulation of cell shape
FORC25_RS10775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC25_RS10785	COG3856	small basic protein
FORC25_RS10795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC25_RS10800	COG0772	Belongs to the SEDS family
FORC25_RS10805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC25_RS10810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC25_RS10820	COG0768	penicillin binding
FORC25_RS10835	COG0012	GTP binding
FORC25_RS10865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC25_RS10870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC25_RS10885	COG0584	glycerophosphoryl diester phosphodiesterase
FORC25_RS10895	COG1683	Conserved Protein
FORC25_RS10900	COG0768	penicillin binding
FORC25_RS10905	COG1193	negative regulation of DNA recombination
FORC25_RS10910	COG0826	peptidase U32
FORC25_RS10915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC25_RS10935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC25_RS10940	COG0569	domain protein
FORC25_RS10945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC25_RS10980	COG0494	nUDIX hydrolase
FORC25_RS11015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC25_RS11030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC25_RS11045	COG0436	Aminotransferase
FORC25_RS11050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC25_RS11055	COG2171	N-acyltransferase activity
FORC25_RS11065	COG0726	polysaccharide deacetylase
FORC25_RS11075	COG0628	permease
FORC25_RS11085	COG1272	protein, Hemolysin III
FORC25_RS11095	COG0038	chloride channel
FORC25_RS11100	COG0285	dihydrofolate synthase activity
FORC25_RS11120	COG2137	regulation of response to DNA damage stimulus
FORC25_RS11125	COG0612	Peptidase, M16
FORC25_RS11130	COG0745	RESPONSE REGULATOR receiver
FORC25_RS11135	COG5002	protein histidine kinase activity
FORC25_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
FORC25_RS11150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC25_RS11155	COG2966	Psort location CytoplasmicMembrane, score
FORC25_RS11165	COG1937	Protein conserved in bacteria
FORC25_RS11170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC25_RS11175	COG0124	histidyl-tRNA synthetase
FORC25_RS11180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC25_RS11185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC25_RS11195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC25_RS11210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC25_RS11215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC25_RS11230	COG1862	Preprotein translocase
FORC25_RS11260	COG0737	Belongs to the 5'-nucleotidase family
FORC25_RS11265	COG0737	Belongs to the 5'-nucleotidase family
FORC25_RS11285	COG1739	Uncharacterized protein family UPF0029
FORC25_RS11290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC25_RS11305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC25_RS11310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FORC25_RS11320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC25_RS11325	COG1115	amino acid carrier protein
FORC25_RS11345	COG3842	ATPase activity
FORC25_RS11355	COG1177	transmembrane transport
FORC25_RS11365	COG0105	UTP biosynthetic process
FORC25_RS11380	COG1686	Belongs to the peptidase S11 family
FORC25_RS11405	COG1346	cytolysis
FORC25_RS11420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FORC25_RS11425	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FORC25_RS11430	COG5002	protein histidine kinase activity
FORC25_RS11435	COG5002	protein histidine kinase activity
FORC25_RS11445	COG2267	carboxylic ester hydrolase activity
FORC25_RS11475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC25_RS11475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC25_RS11500	COG4632	Exopolysaccharide biosynthesis protein
FORC25_RS11500	COG5434	Belongs to the glycosyl hydrolase 28 family
FORC25_RS11535	COG2384	SAM-dependent methyltransferase
FORC25_RS11545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC25_RS11550	COG0358	DNA primase activity
FORC25_RS11565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC25_RS11565	COG0574	Belongs to the PEP-utilizing enzyme family
FORC25_RS11570	COG0517	IMP dehydrogenase activity
FORC25_RS11595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC25_RS11600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC25_RS11605	COG1480	7TM receptor with intracellular HD hydrolase
FORC25_RS11620	COG1610	YqeY-like protein
FORC25_RS11630	COG0537	adenosine 5'-monophosphoramidase activity
FORC25_RS11635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC25_RS11640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC25_RS11650	COG1725	Transcriptional regulator
FORC25_RS11665	COG1131	(ABC) transporter
FORC25_RS11690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC25_RS11715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FORC25_RS11740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC25_RS11755	COG2172	sigma factor antagonist activity
FORC25_RS11765	COG1067	ATP-dependent peptidase activity
FORC25_RS11780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FORC25_RS11800	COG0076	glutamate decarboxylase activity
FORC25_RS11810	COG0531	amino acid
FORC25_RS11825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC25_RS11835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC25_RS11835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FORC25_RS11840	COG0612	Peptidase, M16
FORC25_RS11850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC25_RS11855	COG0187	DNA topoisomerase II activity
FORC25_RS11860	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FORC25_RS11875	COG1971	Probably functions as a manganese efflux pump
FORC25_RS11880	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC25_RS11885	COG0531	amino acid
FORC25_RS11910	COG0383	alpha-mannosidase activity
FORC25_RS11915	COG0395	ABC-type sugar transport system, permease component
FORC25_RS11920	COG4209	transmembrane transport
FORC25_RS11925	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC25_RS11930	COG4149	molybdate abc transporter
FORC25_RS11935	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC25_RS11940	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC25_RS11945	COG2207	Transcriptional regulator
FORC25_RS11945	COG4753	response regulator
FORC25_RS11950	COG2972	Histidine kinase
FORC25_RS11960	COG2348	transferase activity, transferring amino-acyl groups
FORC25_RS11965	COG1695	Transcriptional regulator
FORC25_RS11970	COG1126	abc transporter atp-binding protein
FORC25_RS11990	COG1550	Protein conserved in bacteria
FORC25_RS12000	COG2264	protein methyltransferase activity
FORC25_RS12020	COG1404	Belongs to the peptidase S8 family
FORC25_RS12025	COG1396	sequence-specific DNA binding
FORC25_RS12030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC25_RS12060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FORC25_RS12080	COG1921	L-seryl-tRNASec selenium transferase activity
FORC25_RS12085	COG0709	Synthesizes selenophosphate from selenide and ATP
FORC25_RS12090	COG1555	photosystem II stabilization
FORC25_RS12090	COG1596	polysaccharide export
FORC25_RS12095	COG1686	Belongs to the peptidase S11 family
FORC25_RS12100	COG0564	pseudouridine synthase activity
FORC25_RS12105	COG1316	TRANSCRIPTIONal
FORC25_RS12110	COG1713	HD superfamily hydrolase involved in NAD metabolism
FORC25_RS12115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC25_RS12120	COG1534	Rna-binding protein
FORC25_RS12145	COG1530	ribonuclease E activity
FORC25_RS12160	COG1994	Peptidase M50
FORC25_RS12170	COG0772	Belongs to the SEDS family
FORC25_RS12175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC25_RS12180	COG2894	cell division
FORC25_RS12190	COG0768	penicillin binding
FORC25_RS12190	COG0768	penicillin binding
FORC25_RS12205	COG1077	Cell shape determining protein MreB Mrl
FORC25_RS12225	COG0613	PHP domain protein
FORC25_RS12230	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC25_RS12240	COG0539	negative regulation of cytoplasmic translation
FORC25_RS12275	COG1263	PTS System
FORC25_RS12275	COG2190	(PTS) system
FORC25_RS12275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC25_RS12280	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC25_RS12285	COG4717	serine-type aminopeptidase activity
FORC25_RS12315	COG0517	IMP dehydrogenase activity
FORC25_RS12325	COG0802	atpase or kinase
FORC25_RS12330	COG1214	PFAM Peptidase M22, glycoprotease
FORC25_RS12335	COG0456	acetyltransferase
FORC25_RS12340	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FORC25_RS12345	COG2183	response to ionizing radiation
FORC25_RS12350	COG2234	aminopeptidase activity
FORC25_RS12355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC25_RS12360	COG0653	protein targeting
FORC25_RS12380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC25_RS12445	COG1609	Transcriptional regulator
FORC25_RS12455	COG2385	sporulation resulting in formation of a cellular spore
FORC25_RS12475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC25_RS12485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC25_RS12490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC25_RS12495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FORC25_RS12500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC25_RS12505	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC25_RS12515	COG0183	Belongs to the thiolase family
FORC25_RS12520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC25_RS12525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC25_RS12530	COG0698	ribose 5-phosphate isomerase
FORC25_RS12535	COG0009	L-threonylcarbamoyladenylate synthase
FORC25_RS12555	COG1435	thymidine kinase activity
FORC25_RS12565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC25_RS12570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC25_RS12580	COG4506	Protein conserved in bacteria
FORC25_RS12585	COG0482	sulfurtransferase activity
FORC25_RS12595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC25_RS12605	COG4242	Belongs to the peptidase S51 family
FORC25_RS12615	COG4466	Protein conserved in bacteria
FORC25_RS12625	COG3642	lipopolysaccharide core region biosynthetic process
FORC25_RS12630	COG0438	transferase activity, transferring glycosyl groups
FORC25_RS12665	COG4939	FMN-binding domain protein
FORC25_RS12675	COG3192	ethanolamine utilization protein
FORC25_RS12685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC25_RS12695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC25_RS12715	COG0425	Belongs to the sulfur carrier protein TusA family
FORC25_RS12720	COG1368	sulfuric ester hydrolase activity
FORC25_RS12730	COG3850	Histidine kinase
FORC25_RS12730	COG5002	protein histidine kinase activity
FORC25_RS12735	COG0745	RESPONSE REGULATOR receiver
FORC25_RS12780	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC25_RS12810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC25_RS12875	COG0582	viral genome integration into host DNA
FORC25_RS13020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC25_RS13045	COG1187	pseudouridine synthase activity
FORC25_RS13055	COG1671	Belongs to the UPF0178 family
FORC25_RS13060	COG0166	Belongs to the GPI family
FORC25_RS13070	COG4608	Belongs to the ABC transporter superfamily
FORC25_RS13075	COG0444	Belongs to the ABC transporter superfamily
FORC25_RS13080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC25_RS13085	COG0601	transmembrane transport
FORC25_RS13105	COG0517	IMP dehydrogenase activity
FORC25_RS13105	COG0516	GMP reductase activity
FORC25_RS13150	COG1459	type II secretion system
FORC25_RS13155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC25_RS13160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FORC25_RS13170	COG0459	protein refolding
FORC25_RS13185	COG1403	HNH endonuclease
FORC25_RS13200	COG0681	Belongs to the peptidase S26 family
FORC25_RS13205	COG1132	(ABC) transporter
FORC25_RS13210	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC25_RS13220	COG2086	electron transfer activity
FORC25_RS13225	COG1960	acyl-CoA dehydrogenase activity
FORC25_RS13230	COG1024	Enoyl-CoA hydratase
FORC25_RS13235	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FORC25_RS13240	COG2217	Heavy metal translocating P-type atpase
FORC25_RS13265	COG0662	Cupin 2, conserved barrel domain protein
FORC25_RS13265	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FORC25_RS13270	COG2723	6-phospho-beta-galactosidase activity
FORC25_RS13275	COG1012	belongs to the aldehyde dehydrogenase family
FORC25_RS13285	COG1073	alpha beta
FORC25_RS13290	COG1187	pseudouridine synthase activity
FORC25_RS13300	COG3764	Sortase (surface protein transpeptidase)
FORC25_RS13305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC25_RS13310	COG1757	Na H antiporter
FORC25_RS13380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC25_RS13390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC25_RS13410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC25_RS13420	COG5002	protein histidine kinase activity
FORC25_RS13425	COG0745	RESPONSE REGULATOR receiver
FORC25_RS13435	COG4496	protein, YerC YecD
FORC25_RS13450	COG0058	SHG alpha-glucan phosphorylase activity
FORC25_RS13470	COG3833	ABC-type maltose transport systems, permease component
FORC25_RS13475	COG1175	transmembrane transport
FORC25_RS13480	COG2182	Extracellular solute-binding protein
FORC25_RS13485	COG3835	regulator
FORC25_RS13490	COG3842	ATPase activity
FORC25_RS13500	COG3426	butyrate kinase activity
FORC25_RS13505	COG0280	phosphate acetyltransferase
FORC25_RS13510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC25_RS13520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FORC25_RS13540	COG3118	belongs to the thioredoxin family
FORC25_RS13545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC25_RS13550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC25_RS13555	COG3290	protein histidine kinase activity
FORC25_RS13555	COG3829	transcription factor binding
FORC25_RS13565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC25_RS13570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC25_RS13575	COG1393	Belongs to the ArsC family
FORC25_RS13580	COG5002	protein histidine kinase activity
FORC25_RS13590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC25_RS13595	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC25_RS13620	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FORC25_RS13625	COG1122	ATPase activity
FORC25_RS13630	COG1122	ATPase activity
FORC25_RS13645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FORC25_RS13685	COG0201	protein transport
FORC25_RS13730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC25_RS13740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC25_RS13780	COG0088	Forms part of the polypeptide exit tunnel
FORC25_RS13785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC25_RS13815	COG1358	cellular component organization or biogenesis
FORC25_RS13855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC25_RS13885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC25_RS13905	COG0442	prolyl-tRNA aminoacylation
FORC25_RS13910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC25_RS13915	COG4956	integral membrane protein (PIN domain superfamily)
FORC25_RS13930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC25_RS13940	COG2188	Transcriptional regulator
FORC25_RS13950	COG1012	belongs to the aldehyde dehydrogenase family
FORC25_RS13965	COG0542	response to heat
FORC25_RS13985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FORC25_RS13990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC25_RS13990	COG0189	ligase activity
FORC25_RS14000	COG1774	PSP1 C-terminal conserved region
FORC25_RS14005	COG0470	DNA polymerase III
FORC25_RS14010	COG3870	Protein conserved in bacteria
FORC25_RS14015	COG0194	GDP metabolic process
FORC25_RS14020	COG1982	Orn Lys Arg decarboxylase major
FORC25_RS14045	COG1619	proteins homologs of microcin C7 resistance protein MccF
FORC25_RS14100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC25_RS14110	COG1619	proteins homologs of microcin C7 resistance protein MccF
FORC25_RS14115	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC25_RS14130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC25_RS14140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC25_RS14155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC25_RS14160	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FORC25_RS14165	COG0037	tRNA processing
FORC25_RS14210	COG1098	S1 RNA binding domain
FORC25_RS14230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC25_RS14240	COG3956	TIGRFAM MazG family protein
FORC25_RS14245	COG2244	polysaccharide biosynthetic process
FORC25_RS14250	COG2002	toxin-antitoxin pair type II binding
FORC25_RS14255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC25_RS14260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC25_RS14265	COG0193	aminoacyl-tRNA hydrolase activity
FORC25_RS14270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC25_RS14275	COG2205	protein histidine kinase activity
FORC25_RS14280	COG0745	RESPONSE REGULATOR receiver
FORC25_RS14290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC25_RS14295	COG2088	sporulation resulting in formation of a cellular spore
FORC25_RS14300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC25_RS14320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC25_RS14325	COG0006	proline dipeptidase activity
FORC25_RS14365	COG0534	Mate efflux family protein
FORC25_RS14375	COG1328	CTP reductase activity
FORC25_RS14380	COG1470	cell adhesion involved in biofilm formation
FORC25_RS14390	COG1695	Transcriptional regulator
FORC25_RS14430	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FORC25_RS14435	COG3584	3D domain protein
FORC25_RS14435	COG3583	domain protein
FORC25_RS14440	COG0084	hydrolase, TatD family'
FORC25_RS14445	COG4399	Belongs to the UPF0754 family
FORC25_RS14455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC25_RS14475	COG1757	Na H antiporter
FORC25_RS14490	COG0006	proline dipeptidase activity
FORC25_RS14500	COG0700	Nucleoside recognition
FORC25_RS14505	COG2715	membrane protein required for spore maturation
FORC25_RS14560	COG0488	(ABC) transporter
FORC25_RS14570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC25_RS14590	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC25_RS14600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC25_RS14605	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FORC25_RS14610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC25_RS14620	COG2045	Belongs to the ComB family
FORC25_RS14625	COG1242	4 iron, 4 sulfur cluster binding
FORC25_RS14635	COG3949	Membrane
FORC25_RS14655	COG1404	Belongs to the peptidase S8 family
FORC25_RS14670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC25_RS14685	COG0174	glutamine synthetase
FORC25_RS14700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC25_RS14725	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC25_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
FORC25_RS14745	COG0300	oxidoreductase activity
FORC25_RS14765	COG3314	Sporulation integral membrane protein YlbJ
FORC25_RS14775	COG0110	maltose O-acetyltransferase activity
FORC25_RS14780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC25_RS14800	COG2824	Alkylphosphonate utilization operon protein PhnA
FORC25_RS14835	COG1028	Short-chain dehydrogenase reductase Sdr
FORC25_RS14860	COG0653	protein targeting
FORC25_RS14870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FORC25_RS14895	COG1404	Belongs to the peptidase S8 family
FORC25_RS14900	COG0739	heme binding
FORC25_RS14900	COG0741	lytic transglycosylase activity
FORC25_RS14900	COG1196	nuclear chromosome segregation
FORC25_RS14970	COG2081	HI0933 family
FORC25_RS14985	COG1592	Rubrerythrin
FORC25_RS14985	COG1773	rubredoxin
FORC25_RS14995	COG0494	nUDIX hydrolase
FORC25_RS15005	COG1760	l-serine dehydratase
FORC25_RS15010	COG1760	l-serine dehydratase
FORC25_RS15015	COG2222	sugar isomerase
FORC25_RS15025	COG2188	Transcriptional regulator
FORC25_RS15040	COG3716	PTS system mannose fructose sorbose family IID component
FORC25_RS15045	COG3715	PTS system
FORC25_RS15055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC25_RS15060	COG0305	Participates in initiation and elongation during chromosome replication
FORC25_RS15065	COG1067	ATP-dependent peptidase activity
FORC25_RS15065	COG0470	DNA polymerase III
FORC25_RS15075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FORC25_RS15080	COG4241	membrane
FORC25_RS15110	COG0668	transmembrane transport
FORC25_RS15125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC25_RS15130	COG0628	permease
FORC25_RS15145	COG1475	DNA binding
FORC25_RS15150	COG1192	Involved in chromosome partitioning
FORC25_RS15155	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC25_RS15165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC25_RS15170	COG1847	R3H domain protein