locus-tag	class	description
CLOBY_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLOBY_RS00010	COG0592	DNA-directed DNA polymerase activity
CLOBY_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOBY_RS00030	COG0187	DNA topoisomerase II activity
CLOBY_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOBY_RS00070	COG1827	regulation of RNA biosynthetic process
CLOBY_RS00115	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLOBY_RS00120	COG1074	ATP-dependent DNA helicase activity
CLOBY_RS00125	COG1376	ErfK ybiS ycfS ynhG family protein
CLOBY_RS00135	COG5002	protein histidine kinase activity
CLOBY_RS00145	COG0582	viral genome integration into host DNA
CLOBY_RS00170	COG1674	ftsk spoiiie
CLOBY_RS00200	COG0789	Transcriptional regulator
CLOBY_RS00200	COG4978	Transcriptional regulator
CLOBY_RS00215	COG0688	phosphatidylethanolamine metabolic process
CLOBY_RS00230	COG0488	(ABC) transporter
CLOBY_RS00255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLOBY_RS00260	COG1803	Methylglyoxal synthase
CLOBY_RS00275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLOBY_RS00295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLOBY_RS00320	COG3949	Membrane
CLOBY_RS00325	COG1242	4 iron, 4 sulfur cluster binding
CLOBY_RS00330	COG2045	Belongs to the ComB family
CLOBY_RS00355	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS00360	COG5002	protein histidine kinase activity
CLOBY_RS00385	COG1846	Transcriptional regulator
CLOBY_RS00390	COG0534	Mate efflux family protein
CLOBY_RS00400	COG2715	membrane protein required for spore maturation
CLOBY_RS00405	COG0700	Nucleoside recognition
CLOBY_RS00410	COG0006	proline dipeptidase activity
CLOBY_RS00430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOBY_RS00435	COG0084	hydrolase, TatD family'
CLOBY_RS00440	COG3583	domain protein
CLOBY_RS00440	COG3584	3D domain protein
CLOBY_RS00480	COG1141	Ferredoxin
CLOBY_RS00500	COG1328	CTP reductase activity
CLOBY_RS00505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOBY_RS00510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOBY_RS00515	COG0602	queuosine metabolic process
CLOBY_RS00525	COG2094	Belongs to the DNA glycosylase MPG family
CLOBY_RS00535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLOBY_RS00545	COG0463	Glycosyl transferase, family 2
CLOBY_RS00550	COG0463	Glycosyl transferase, family 2
CLOBY_RS00555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLOBY_RS00565	COG3681	Belongs to the UPF0597 family
CLOBY_RS00575	COG0017	Asparaginyl-tRNA synthetase
CLOBY_RS00590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLOBY_RS00595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOBY_RS00600	COG2088	sporulation resulting in formation of a cellular spore
CLOBY_RS00605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLOBY_RS00615	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS00620	COG3850	Histidine kinase
CLOBY_RS00620	COG5002	protein histidine kinase activity
CLOBY_RS00625	COG0193	aminoacyl-tRNA hydrolase activity
CLOBY_RS00630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLOBY_RS00655	COG2002	toxin-antitoxin pair type II binding
CLOBY_RS00660	COG2244	polysaccharide biosynthetic process
CLOBY_RS00665	COG3956	TIGRFAM MazG family protein
CLOBY_RS00675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLOBY_RS00695	COG1098	S1 RNA binding domain
CLOBY_RS00750	COG2208	phosphoserine phosphatase activity
CLOBY_RS00755	COG0037	tRNA processing
CLOBY_RS00760	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLOBY_RS00765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOBY_RS00770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CLOBY_RS00775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLOBY_RS00780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLOBY_RS00785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLOBY_RS00790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLOBY_RS00810	COG0423	glycine-tRNA ligase activity
CLOBY_RS00815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLOBY_RS00880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLOBY_RS00885	COG3870	Protein conserved in bacteria
CLOBY_RS00890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOBY_RS00895	COG1774	PSP1 C-terminal conserved region
CLOBY_RS00910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOBY_RS00920	COG3880	PFAM UvrB UvrC protein
CLOBY_RS00930	COG0542	response to heat
CLOBY_RS00945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLOBY_RS00950	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CLOBY_RS00960	COG4956	integral membrane protein (PIN domain superfamily)
CLOBY_RS00965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLOBY_RS00970	COG0442	prolyl-tRNA aminoacylation
CLOBY_RS00975	COG0215	cysteine-tRNA ligase activity
CLOBY_RS00985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOBY_RS01005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLOBY_RS01010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLOBY_RS01015	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLOBY_RS01025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLOBY_RS01030	COG0081	regulation of translation
CLOBY_RS01045	COG0085	RNA polymerase activity
CLOBY_RS01050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLOBY_RS01065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOBY_RS01070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLOBY_RS01075	COG0051	transcription antitermination factor activity, RNA binding
CLOBY_RS01080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLOBY_RS01085	COG0088	Forms part of the polypeptide exit tunnel
CLOBY_RS01090	COG0089	rRNA binding
CLOBY_RS01095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLOBY_RS01100	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLOBY_RS01105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLOBY_RS01110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLOBY_RS01115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLOBY_RS01120	COG0255	Belongs to the universal ribosomal protein uL29 family
CLOBY_RS01125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLOBY_RS01130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLOBY_RS01135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLOBY_RS01140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLOBY_RS01150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLOBY_RS01155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLOBY_RS01160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLOBY_RS01170	COG1841	ribosomal large subunit assembly
CLOBY_RS01175	COG0200	Binds to the 23S rRNA
CLOBY_RS01180	COG0201	protein transport
CLOBY_RS01185	COG0563	adenylate kinase activity
CLOBY_RS01200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLOBY_RS01205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLOBY_RS01210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLOBY_RS01215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLOBY_RS01220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOBY_RS01225	COG0202	RNA polymerase activity
CLOBY_RS01230	COG0203	ribosomal protein L17
CLOBY_RS01235	COG1122	ATPase activity
CLOBY_RS01240	COG1122	ATPase activity
CLOBY_RS01245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLOBY_RS01250	COG0101	tRNA pseudouridine synthase activity
CLOBY_RS01255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLOBY_RS01260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLOBY_RS01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOBY_RS01285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOBY_RS01305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLOBY_RS01310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLOBY_RS01315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOBY_RS01325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLOBY_RS01330	COG3773	Cell wall hydrolase
CLOBY_RS01340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLOBY_RS01355	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLOBY_RS01360	COG0280	phosphate acetyltransferase
CLOBY_RS01370	COG1418	mRNA catabolic process
CLOBY_RS01375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLOBY_RS01380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLOBY_RS01380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLOBY_RS01390	COG4496	protein, YerC YecD
CLOBY_RS01395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOBY_RS01405	COG0071	Belongs to the small heat shock protein (HSP20) family
CLOBY_RS01415	COG0440	acetolactate synthase activity
CLOBY_RS01420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOBY_RS01425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOBY_RS01430	COG0066	3-isopropylmalate dehydratase activity
CLOBY_RS01435	COG0473	3-isopropylmalate dehydrogenase activity
CLOBY_RS01445	COG0028	Belongs to the TPP enzyme family
CLOBY_RS01450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLOBY_RS01485	COG1136	(ABC) transporter
CLOBY_RS01490	COG0577	efflux transmembrane transporter activity
CLOBY_RS01495	COG0626	cystathionine gamma-synthase activity
CLOBY_RS01500	COG0626	cystathionine gamma-synthase activity
CLOBY_RS01515	COG1846	Transcriptional regulator
CLOBY_RS01565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLOBY_RS01575	COG4152	abc transporter atp-binding protein
CLOBY_RS01590	COG1032	radical SAM domain protein
CLOBY_RS01620	COG0840	transmembrane signaling receptor activity
CLOBY_RS01625	COG0840	transmembrane signaling receptor activity
CLOBY_RS01630	COG0840	transmembrane signaling receptor activity
CLOBY_RS01640	COG2116	formate transmembrane transporter activity
CLOBY_RS01650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLOBY_RS01660	COG2873	o-acetylhomoserine
CLOBY_RS01670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLOBY_RS01690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLOBY_RS01700	COG0726	polysaccharide deacetylase
CLOBY_RS01710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOBY_RS01740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLOBY_RS01750	COG2186	Transcriptional regulator
CLOBY_RS01755	COG2086	electron transfer activity
CLOBY_RS01760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOBY_RS01765	COG0277	FAD linked oxidase domain protein
CLOBY_RS01770	COG0653	protein targeting
CLOBY_RS01775	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CLOBY_RS01775	COG0662	Cupin 2, conserved barrel domain protein
CLOBY_RS01790	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLOBY_RS01795	COG1024	Enoyl-CoA hydratase
CLOBY_RS01800	COG1960	acyl-CoA dehydrogenase activity
CLOBY_RS01805	COG2086	electron transfer activity
CLOBY_RS01815	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLOBY_RS01830	COG1403	HNH endonuclease
CLOBY_RS01840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLOBY_RS01845	COG0459	protein refolding
CLOBY_RS01855	COG0516	GMP reductase activity
CLOBY_RS01855	COG0517	IMP dehydrogenase activity
CLOBY_RS01895	COG2946	Replication initiation factor
CLOBY_RS01925	COG0166	Belongs to the GPI family
CLOBY_RS01930	COG1671	Belongs to the UPF0178 family
CLOBY_RS01935	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS01940	COG5002	protein histidine kinase activity
CLOBY_RS01940	COG3850	Histidine kinase
CLOBY_RS01965	COG0741	lytic transglycosylase activity
CLOBY_RS01970	COG1187	pseudouridine synthase activity
CLOBY_RS01980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLOBY_RS02025	COG0622	Phosphoesterase
CLOBY_RS02125	COG0582	viral genome integration into host DNA
CLOBY_RS02155	COG1484	DNA-dependent DNA replication
CLOBY_RS02160	COG2002	toxin-antitoxin pair type II binding
CLOBY_RS02195	COG0586	Pfam SNARE associated Golgi protein
CLOBY_RS02205	COG0861	Integral membrane protein TerC family
CLOBY_RS02345	COG2801	Transposase and inactivated derivatives
CLOBY_RS02375	COG3590	peptidase
CLOBY_RS02405	COG0312	modulator of DNA gyrase
CLOBY_RS02410	COG0312	modulator of DNA gyrase
CLOBY_RS02415	COG1368	sulfuric ester hydrolase activity
CLOBY_RS02440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLOBY_RS02450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLOBY_RS02500	COG0840	transmembrane signaling receptor activity
CLOBY_RS02505	COG4466	Protein conserved in bacteria
CLOBY_RS02510	COG0791	NLP P60 protein
CLOBY_RS02510	COG1388	LysM domain
CLOBY_RS02520	COG0189	ligase activity
CLOBY_RS02520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOBY_RS02525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLOBY_RS02535	COG0482	sulfurtransferase activity
CLOBY_RS02550	COG0504	CTP synthase activity
CLOBY_RS02555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLOBY_RS02560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOBY_RS02565	COG0254	rRNA binding
CLOBY_RS02580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLOBY_RS02590	COG0009	L-threonylcarbamoyladenylate synthase
CLOBY_RS02595	COG0698	ribose 5-phosphate isomerase
CLOBY_RS02600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLOBY_RS02610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOBY_RS02615	COG0183	Belongs to the thiolase family
CLOBY_RS02625	COG0356	it plays a direct role in the translocation of protons across the membrane
CLOBY_RS02630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOBY_RS02635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLOBY_RS02645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLOBY_RS02650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLOBY_RS02655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLOBY_RS02675	COG2385	sporulation resulting in formation of a cellular spore
CLOBY_RS02685	COG1609	Transcriptional regulator
CLOBY_RS02745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOBY_RS02755	COG1040	competence protein
CLOBY_RS02765	COG0653	protein targeting
CLOBY_RS02770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLOBY_RS02790	COG5002	protein histidine kinase activity
CLOBY_RS02800	COG2183	response to ionizing radiation
CLOBY_RS02805	COG3949	Membrane
CLOBY_RS02810	COG1473	amidohydrolase
CLOBY_RS02820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLOBY_RS02840	COG0494	nUDIX hydrolase
CLOBY_RS02845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLOBY_RS02860	COG4656	Part of a membrane complex involved in electron transport
CLOBY_RS02865	COG4658	electron transport chain
CLOBY_RS02870	COG4659	FMN binding
CLOBY_RS02875	COG4660	Part of a membrane complex involved in electron transport
CLOBY_RS02880	COG4657	Part of a membrane complex involved in electron transport
CLOBY_RS02885	COG2878	Part of a membrane complex involved in electron transport
CLOBY_RS02885	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOBY_RS02930	COG2703	oxygen carrier activity
CLOBY_RS02940	COG0456	acetyltransferase
CLOBY_RS02945	COG1214	PFAM Peptidase M22, glycoprotease
CLOBY_RS02950	COG0802	atpase or kinase
CLOBY_RS02985	COG1136	(ABC) transporter
CLOBY_RS02995	COG0534	Mate efflux family protein
CLOBY_RS03020	COG1773	rubredoxin
CLOBY_RS03020	COG1592	Rubrerythrin
CLOBY_RS03025	COG0426	domain, Protein
CLOBY_RS03030	COG0251	oxidation-reduction process
CLOBY_RS03035	COG2070	2-Nitropropane dioxygenase
CLOBY_RS03065	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLOBY_RS03070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOBY_RS03090	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS03095	COG5002	protein histidine kinase activity
CLOBY_RS03100	COG1136	(ABC) transporter
CLOBY_RS03100	COG0577	efflux transmembrane transporter activity
CLOBY_RS03105	COG0577	efflux transmembrane transporter activity
CLOBY_RS03110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOBY_RS03140	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOBY_RS03145	COG0791	NLP P60 protein
CLOBY_RS03155	COG0424	maF-like protein
CLOBY_RS03160	COG2003	Belongs to the UPF0758 family
CLOBY_RS03165	COG1077	Cell shape determining protein MreB Mrl
CLOBY_RS03170	COG1792	Involved in formation and maintenance of cell shape
CLOBY_RS03180	COG0768	penicillin binding
CLOBY_RS03190	COG1489	DNA binding
CLOBY_RS03200	COG2894	cell division
CLOBY_RS03205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLOBY_RS03210	COG0772	Belongs to the SEDS family
CLOBY_RS03245	COG1530	ribonuclease E activity
CLOBY_RS03260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLOBY_RS03265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLOBY_RS03270	COG1534	Rna-binding protein
CLOBY_RS03275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLOBY_RS03280	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLOBY_RS03285	COG1316	TRANSCRIPTIONal
CLOBY_RS03290	COG0564	pseudouridine synthase activity
CLOBY_RS03295	COG1686	Belongs to the peptidase S11 family
CLOBY_RS03300	COG1596	polysaccharide export
CLOBY_RS03300	COG1555	photosystem II stabilization
CLOBY_RS03335	COG2310	stress, protein
CLOBY_RS03345	COG2310	stress, protein
CLOBY_RS03355	COG0861	Integral membrane protein TerC family
CLOBY_RS03375	COG0443	Heat shock 70 kDa protein
CLOBY_RS03380	COG0443	Heat shock 70 kDa protein
CLOBY_RS03390	COG0443	Heat shock 70 kDa protein
CLOBY_RS03400	COG1131	(ABC) transporter
CLOBY_RS03420	COG0737	Belongs to the 5'-nucleotidase family
CLOBY_RS03425	COG1966	Carbon starvation protein
CLOBY_RS03445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOBY_RS03450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLOBY_RS03455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLOBY_RS03460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLOBY_RS03465	COG1605	Chorismate mutase
CLOBY_RS03465	COG0077	Prephenate dehydratase
CLOBY_RS03470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLOBY_RS03480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOBY_RS03490	COG3507	Belongs to the glycosyl hydrolase 43 family
CLOBY_RS03495	COG0726	polysaccharide deacetylase
CLOBY_RS03520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOBY_RS03525	COG0583	DNA-binding transcription factor activity
CLOBY_RS03535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLOBY_RS03540	COG0738	Major facilitator superfamily
CLOBY_RS03550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLOBY_RS03555	COG0738	Major facilitator superfamily
CLOBY_RS03560	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CLOBY_RS03575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLOBY_RS03595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLOBY_RS03600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLOBY_RS03605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLOBY_RS03610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLOBY_RS03615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLOBY_RS03620	COG0165	Argininosuccinate lyase
CLOBY_RS03625	COG0137	argininosuccinate synthase activity
CLOBY_RS03635	COG2323	membrane
CLOBY_RS03640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOBY_RS03650	COG1760	l-serine dehydratase
CLOBY_RS03655	COG1760	l-serine dehydratase
CLOBY_RS03660	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS03665	COG5002	protein histidine kinase activity
CLOBY_RS03675	COG0348	domain, Protein
CLOBY_RS03675	COG3901	Regulator of nitric oxide reductase transcription
CLOBY_RS03700	COG0351	phosphomethylpyrimidine kinase
CLOBY_RS03710	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLOBY_RS03715	COG0352	thiamine-phosphate diphosphorylase activity
CLOBY_RS03720	COG3706	GGDEF domain
CLOBY_RS03725	COG0514	ATP-dependent DNA helicase (RecQ)
CLOBY_RS03730	COG3328	transposase activity
CLOBY_RS03735	COG0613	PHP domain protein
CLOBY_RS03740	COG1126	abc transporter atp-binding protein
CLOBY_RS03750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOBY_RS03760	COG2207	Transcriptional regulator
CLOBY_RS03760	COG4753	response regulator
CLOBY_RS03770	COG1879	ABC-type sugar transport system periplasmic component
CLOBY_RS03775	COG1129	ABC transporter
CLOBY_RS03780	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOBY_RS03785	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOBY_RS03790	COG2972	Histidine kinase
CLOBY_RS03800	COG0561	phosphatase activity
CLOBY_RS03805	COG2160	L-arabinose isomerase activity
CLOBY_RS03825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLOBY_RS03835	COG2814	Major facilitator Superfamily
CLOBY_RS03855	COG0288	reversible hydration of carbon dioxide
CLOBY_RS03870	COG0840	transmembrane signaling receptor activity
CLOBY_RS03870	COG5278	phosphoserine phosphatase activity
CLOBY_RS03895	COG1982	Orn Lys Arg decarboxylase major
CLOBY_RS03900	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLOBY_RS03995	COG0484	heat shock protein binding
CLOBY_RS04295	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CLOBY_RS04300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLOBY_RS04305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CLOBY_RS04310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOBY_RS04330	COG1454	alcohol dehydrogenase
CLOBY_RS04340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOBY_RS04345	COG0765	amino acid transport
CLOBY_RS04350	COG2508	Transcriptional regulator
CLOBY_RS04355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CLOBY_RS04370	COG2207	Transcriptional regulator
CLOBY_RS04380	COG1725	Transcriptional regulator
CLOBY_RS04385	COG1131	(ABC) transporter
CLOBY_RS04415	COG0028	Belongs to the TPP enzyme family
CLOBY_RS04415	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CLOBY_RS04420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLOBY_RS04420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLOBY_RS04435	COG2198	Histidine kinase
CLOBY_RS04435	COG0643	Histidine kinase
CLOBY_RS04445	COG0493	'glutamate synthase
CLOBY_RS04445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOBY_RS04450	COG2364	Membrane
CLOBY_RS04460	COG2801	Transposase and inactivated derivatives
CLOBY_RS04530	COG0431	NADPH-dependent FMN reductase
CLOBY_RS04530	COG3976	FMN-binding domain protein
CLOBY_RS04530	COG1053	succinate dehydrogenase
CLOBY_RS04645	COG3617	BRO family, N-terminal domain
CLOBY_RS04675	COG4978	Transcriptional regulator
CLOBY_RS04675	COG0789	Transcriptional regulator
CLOBY_RS04725	COG0629	single-stranded DNA binding
CLOBY_RS04730	COG0642	Histidine kinase
CLOBY_RS04730	COG5002	protein histidine kinase activity
CLOBY_RS04735	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS04740	COG1183	phosphatidylcholine synthase activity
CLOBY_RS04745	COG0628	permease
CLOBY_RS04755	COG1132	(ABC) transporter
CLOBY_RS04760	COG0640	Transcriptional regulator
CLOBY_RS04770	COG0025	NhaP-type Na H and K H
CLOBY_RS04785	COG5520	Belongs to the glycosyl hydrolase 30 family
CLOBY_RS04795	COG0840	transmembrane signaling receptor activity
CLOBY_RS04835	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CLOBY_RS04840	COG1136	(ABC) transporter
CLOBY_RS04850	COG4555	ABC transporter
CLOBY_RS04865	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS04870	COG2205	protein histidine kinase activity
CLOBY_RS04890	COG2188	Transcriptional regulator
CLOBY_RS04895	COG0363	glucosamine-6-phosphate deaminase activity
CLOBY_RS04905	COG3715	PTS system
CLOBY_RS04910	COG3716	PTS system mannose fructose sorbose family IID component
CLOBY_RS04975	COG2723	6-phospho-beta-galactosidase activity
CLOBY_RS04985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOBY_RS04985	COG3711	transcriptional antiterminator
CLOBY_RS04990	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLOBY_RS05000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOBY_RS05005	COG0823	Involved in the tonB-independent uptake of proteins
CLOBY_RS05020	COG1940	carbohydrate kinase activity
CLOBY_RS05025	COG2723	6-phospho-beta-galactosidase activity
CLOBY_RS05035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOBY_RS05040	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLOBY_RS05075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLOBY_RS05100	COG3708	Transcriptional regulator
CLOBY_RS05100	COG2207	Transcriptional regulator
CLOBY_RS05115	COG1263	PTS System
CLOBY_RS05115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOBY_RS05115	COG2190	(PTS) system
CLOBY_RS05120	COG3711	transcriptional antiterminator
CLOBY_RS05125	COG3279	Response regulator of the LytR AlgR family
CLOBY_RS05130	COG1131	(ABC) transporter
CLOBY_RS05155	COG1566	PFAM secretion protein HlyD family protein
CLOBY_RS05160	COG2814	Major facilitator Superfamily
CLOBY_RS05165	COG1846	Transcriptional regulator
CLOBY_RS05170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLOBY_RS05175	COG1360	Flagellar Motor Protein
CLOBY_RS05180	COG0840	transmembrane signaling receptor activity
CLOBY_RS05185	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLOBY_RS05190	COG0698	ribose 5-phosphate isomerase
CLOBY_RS05195	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CLOBY_RS05200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLOBY_RS05210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLOBY_RS05220	COG1737	Transcriptional regulator
CLOBY_RS05225	COG4989	oxidoreductase activity
CLOBY_RS05255	COG2873	o-acetylhomoserine
CLOBY_RS05260	COG0840	transmembrane signaling receptor activity
CLOBY_RS05270	COG1846	Transcriptional regulator
CLOBY_RS05280	COG1349	DNA-binding transcription factor activity
CLOBY_RS05295	COG1253	flavin adenine dinucleotide binding
CLOBY_RS05300	COG0531	amino acid
CLOBY_RS05310	COG1131	(ABC) transporter
CLOBY_RS05315	COG1725	Transcriptional regulator
CLOBY_RS05325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLOBY_RS05335	COG0157	Belongs to the NadC ModD family
CLOBY_RS05340	COG3850	Histidine kinase
CLOBY_RS05340	COG5002	protein histidine kinase activity
CLOBY_RS05345	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS05360	COG1136	(ABC) transporter
CLOBY_RS05365	COG0577	efflux transmembrane transporter activity
CLOBY_RS05375	COG0110	maltose O-acetyltransferase activity
CLOBY_RS05380	COG0840	transmembrane signaling receptor activity
CLOBY_RS05395	COG1067	ATP-dependent peptidase activity
CLOBY_RS05405	COG2172	sigma factor antagonist activity
CLOBY_RS05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOBY_RS05430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLOBY_RS05445	COG0268	Binds directly to 16S ribosomal RNA
CLOBY_RS05470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOBY_RS05475	COG1420	regulation of RNA biosynthetic process
CLOBY_RS05480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLOBY_RS05485	COG0443	Heat shock 70 kDa protein
CLOBY_RS05490	COG0484	heat shock protein binding
CLOBY_RS05495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOBY_RS05500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLOBY_RS05505	COG2264	protein methyltransferase activity
CLOBY_RS05510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLOBY_RS05515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOBY_RS05520	COG0537	adenosine 5'-monophosphoramidase activity
CLOBY_RS05525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLOBY_RS05530	COG1610	YqeY-like protein
CLOBY_RS05545	COG1480	7TM receptor with intracellular HD hydrolase
CLOBY_RS05550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLOBY_RS05555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLOBY_RS05560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLOBY_RS05575	COG0517	IMP dehydrogenase activity
CLOBY_RS05580	COG0574	Belongs to the PEP-utilizing enzyme family
CLOBY_RS05580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOBY_RS05595	COG0358	DNA primase activity
CLOBY_RS05600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOBY_RS05660	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS05675	COG0697	spore germination
CLOBY_RS05680	COG1404	Belongs to the peptidase S8 family
CLOBY_RS05700	COG0058	SHG alpha-glucan phosphorylase activity
CLOBY_RS05705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOBY_RS05710	COG0561	phosphatase activity
CLOBY_RS05715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOBY_RS05720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLOBY_RS05720	COG0512	Glutamine amidotransferase of anthranilate synthase
CLOBY_RS05730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLOBY_RS05735	COG1254	Belongs to the acylphosphatase family
CLOBY_RS05740	COG0105	UTP biosynthetic process
CLOBY_RS05755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLOBY_RS05770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLOBY_RS05785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOBY_RS05790	COG1739	Uncharacterized protein family UPF0029
CLOBY_RS05805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLOBY_RS05810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLOBY_RS05815	COG1459	type II secretion system
CLOBY_RS05860	COG3706	GGDEF domain
CLOBY_RS05865	COG0586	Pfam SNARE associated Golgi protein
CLOBY_RS05870	COG0527	aspartate kinase activity
CLOBY_RS05885	COG0070	glutamate synthase
CLOBY_RS05885	COG0067	glutamate synthase
CLOBY_RS05885	COG0069	glutamate synthase activity
CLOBY_RS05890	COG0493	'glutamate synthase
CLOBY_RS05900	COG0538	isocitrate dehydrogenase activity
CLOBY_RS05910	COG2610	gluconate transmembrane transporter activity
CLOBY_RS05915	COG1929	Belongs to the glycerate kinase type-1 family
CLOBY_RS05935	COG2309	aminopeptidase activity
CLOBY_RS05940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOBY_RS05940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOBY_RS05950	COG0741	lytic transglycosylase activity
CLOBY_RS06005	COG1309	transcriptional regulator
CLOBY_RS06010	COG2936	dipeptidyl-peptidase activity
CLOBY_RS06025	COG5002	protein histidine kinase activity
CLOBY_RS06045	COG2226	methyltransferase
CLOBY_RS06055	COG0004	ammonium transporteR
CLOBY_RS06060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLOBY_RS06065	COG1116	anion transmembrane transporter activity
CLOBY_RS06070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOBY_RS06080	COG1346	cytolysis
CLOBY_RS06095	COG1686	Belongs to the peptidase S11 family
CLOBY_RS06105	COG1349	DNA-binding transcription factor activity
CLOBY_RS06110	COG1454	alcohol dehydrogenase
CLOBY_RS06115	COG0191	fructose-bisphosphate aldolase activity
CLOBY_RS06120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOBY_RS06125	COG3718	enzyme involved in inositol metabolism
CLOBY_RS06135	COG0673	inositol 2-dehydrogenase activity
CLOBY_RS06140	COG1082	Xylose isomerase domain protein TIM barrel
CLOBY_RS06145	COG2814	Major facilitator Superfamily
CLOBY_RS06150	COG3442	glutamine amidotransferase
CLOBY_RS06155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLOBY_RS06165	COG0826	peptidase U32
CLOBY_RS06170	COG1193	negative regulation of DNA recombination
CLOBY_RS06175	COG1683	Conserved Protein
CLOBY_RS06185	COG0420	3'-5' exonuclease activity
CLOBY_RS06190	COG0419	ATPase involved in DNA repair
CLOBY_RS06195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLOBY_RS06200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLOBY_RS06205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOBY_RS06215	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLOBY_RS06220	COG0728	peptidoglycan biosynthetic process
CLOBY_RS06230	COG0438	transferase activity, transferring glycosyl groups
CLOBY_RS06250	COG0012	GTP binding
CLOBY_RS06260	COG1482	cell wall glycoprotein biosynthetic process
CLOBY_RS06265	COG1968	undecaprenyl-diphosphatase activity
CLOBY_RS06280	COG0540	Belongs to the ATCase OTCase family
CLOBY_RS06305	COG0167	dihydroorotate dehydrogenase activity
CLOBY_RS06310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLOBY_RS06350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLOBY_RS06350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLOBY_RS06355	COG5434	Belongs to the glycosyl hydrolase 28 family
CLOBY_RS06355	COG4632	Exopolysaccharide biosynthesis protein
CLOBY_RS06365	COG1994	Peptidase M50
CLOBY_RS06370	COG0018	arginyl-trna synthetase
CLOBY_RS06420	COG2155	Conserved Protein
CLOBY_RS06425	COG1522	sequence-specific DNA binding
CLOBY_RS06450	COG0367	asparagine synthase
CLOBY_RS06460	COG0419	ATPase involved in DNA repair
CLOBY_RS06480	COG3118	belongs to the thioredoxin family
CLOBY_RS06490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLOBY_RS06495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOBY_RS06495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLOBY_RS06515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOBY_RS06520	COG0765	amino acid transport
CLOBY_RS06525	COG1126	abc transporter atp-binding protein
CLOBY_RS06535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLOBY_RS06540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLOBY_RS06550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLOBY_RS06555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLOBY_RS06560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLOBY_RS06565	COG0138	bifunctional purine biosynthesis protein purh
CLOBY_RS06570	COG0151	Belongs to the GarS family
CLOBY_RS06595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOBY_RS06610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLOBY_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
CLOBY_RS06620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLOBY_RS06625	COG0511	ligase activity, forming carbon-carbon bonds
CLOBY_RS06635	COG0439	Biotin carboxylase
CLOBY_RS06640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLOBY_RS06645	COG0825	malonyl-CoA metabolic process
CLOBY_RS06655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLOBY_RS06660	COG1959	2 iron, 2 sulfur cluster binding
CLOBY_RS06670	COG0822	iron-sulfur transferase activity
CLOBY_RS06675	COG0482	sulfurtransferase activity
CLOBY_RS06685	COG0628	permease
CLOBY_RS06690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOBY_RS06700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLOBY_RS06710	COG0735	belongs to the Fur family
CLOBY_RS06715	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLOBY_RS06720	COG1217	gtp-binding protein TYPA
CLOBY_RS06725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLOBY_RS06730	COG4122	O-methyltransferase activity
CLOBY_RS06735	COG0826	peptidase U32
CLOBY_RS06740	COG0768	penicillin binding
CLOBY_RS06755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLOBY_RS06765	COG1191	sigma factor activity
CLOBY_RS06770	COG1191	sigma factor activity
CLOBY_RS06775	COG1873	PFAM PRC-barrel domain
CLOBY_RS06780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLOBY_RS06785	COG1496	oxidoreductase activity
CLOBY_RS06790	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS06795	COG5002	protein histidine kinase activity
CLOBY_RS06800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLOBY_RS06805	COG0573	inorganic phosphate transmembrane transporter activity
CLOBY_RS06810	COG0581	inorganic phosphate transmembrane transporter activity
CLOBY_RS06815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOBY_RS06820	COG0704	Plays a role in the regulation of phosphate uptake
CLOBY_RS06830	COG1160	GTP binding
CLOBY_RS06835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLOBY_RS06840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLOBY_RS06850	COG2252	PERMEase
CLOBY_RS06855	COG1561	YicC-like family, N-terminal region
CLOBY_RS06870	COG1758	RNA polymerase activity
CLOBY_RS06880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLOBY_RS06890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLOBY_RS06895	COG2738	Putative neutral zinc metallopeptidase
CLOBY_RS06900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOBY_RS06900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOBY_RS06905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLOBY_RS06910	COG0631	protein serine/threonine phosphatase activity
CLOBY_RS06920	COG1162	GTPase activity
CLOBY_RS06925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLOBY_RS06930	COG1564	THIamine pyrophosphokinase
CLOBY_RS06935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLOBY_RS06940	COG1302	Protein conserved in bacteria
CLOBY_RS06945	COG1461	Dihydroxyacetone kinase
CLOBY_RS06950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLOBY_RS06955	COG0742	ribosomal rna small subunit methyltransferase
CLOBY_RS06960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLOBY_RS06975	COG1323	Belongs to the UPF0348 family
CLOBY_RS06980	COG0280	phosphate acetyltransferase
CLOBY_RS06985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLOBY_RS07000	COG0416	fatty acid biosynthetic process
CLOBY_RS07010	COG0571	ribonuclease III activity
CLOBY_RS07025	COG0552	protein localization to endoplasmic reticulum
CLOBY_RS07030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CLOBY_RS07035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLOBY_RS07040	COG0228	four-way junction DNA binding
CLOBY_RS07045	COG1837	Belongs to the UPF0109 family
CLOBY_RS07050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLOBY_RS07055	COG0336	Belongs to the RNA methyltransferase TrmD family
CLOBY_RS07060	COG0335	large ribosomal subunit rRNA binding
CLOBY_RS07070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLOBY_RS07075	COG3328	transposase activity
CLOBY_RS07080	COG0792	nuclease activity
CLOBY_RS07085	COG0606	chelatase, subunit chli
CLOBY_RS07090	COG0758	DNA mediated transformation
CLOBY_RS07095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOBY_RS07100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CLOBY_RS07105	COG0052	Belongs to the universal ribosomal protein uS2 family
CLOBY_RS07130	COG4589	Belongs to the CDS family
CLOBY_RS07215	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLOBY_RS07220	COG0779	Required for maturation of 30S ribosomal subunits
CLOBY_RS07225	COG0195	Participates in both transcription termination and antitermination
CLOBY_RS07230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLOBY_RS07240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLOBY_RS07245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLOBY_RS07265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLOBY_RS07270	COG1185	polyribonucleotide nucleotidyltransferase activity
CLOBY_RS07275	COG0612	Peptidase, M16
CLOBY_RS07285	COG0527	aspartate kinase activity
CLOBY_RS07290	COG0740	serine-type endopeptidase activity
CLOBY_RS07300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOBY_RS07305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOBY_RS07310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLOBY_RS07315	COG1418	mRNA catabolic process
CLOBY_RS07320	COG2359	stage V sporulation protein S
CLOBY_RS07325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOBY_RS07330	COG2155	Conserved Protein
CLOBY_RS07335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLOBY_RS07360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOBY_RS07360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOBY_RS07380	COG0517	IMP dehydrogenase activity
CLOBY_RS07380	COG1125	glycine betaine transport
CLOBY_RS07385	COG1174	glycine betaine transport
CLOBY_RS07395	COG1773	rubredoxin
CLOBY_RS07395	COG1592	Rubrerythrin
CLOBY_RS07400	COG0778	Nitroreductase
CLOBY_RS07445	COG0371	Dehydrogenase
CLOBY_RS07455	COG1959	2 iron, 2 sulfur cluster binding
CLOBY_RS07485	COG0583	DNA-binding transcription factor activity
CLOBY_RS07495	COG0784	Response regulator, receiver
CLOBY_RS07495	COG0835	chemotaxis
CLOBY_RS07505	COG1924	4 iron, 4 sulfur cluster binding
CLOBY_RS07525	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOBY_RS07530	COG1550	Protein conserved in bacteria
CLOBY_RS07535	COG1733	regulation of RNA biosynthetic process
CLOBY_RS07545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLOBY_RS07555	COG0628	permease
CLOBY_RS07560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOBY_RS07570	COG0693	protein deglycase activity
CLOBY_RS07575	COG2378	regulation of single-species biofilm formation
CLOBY_RS07590	COG1695	Transcriptional regulator
CLOBY_RS07620	COG0826	peptidase U32
CLOBY_RS07625	COG1012	belongs to the aldehyde dehydrogenase family
CLOBY_RS07635	COG2703	oxygen carrier activity
CLOBY_RS07645	COG0671	phosphoesterase, PA-phosphatase related
CLOBY_RS07660	COG1027	Aspartate ammonia-lyase
CLOBY_RS07665	COG1522	sequence-specific DNA binding
CLOBY_RS07670	COG2226	methyltransferase
CLOBY_RS07685	COG0726	polysaccharide deacetylase
CLOBY_RS07700	COG2848	UPF0210 protein
CLOBY_RS07725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOBY_RS07730	COG0708	Exodeoxyribonuclease III
CLOBY_RS07750	COG1234	tRNA 3'-trailer cleavage
CLOBY_RS07780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLOBY_RS07815	COG0602	queuosine metabolic process
CLOBY_RS07820	COG0302	gtp cyclohydrolase
CLOBY_RS07825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLOBY_RS07830	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLOBY_RS07855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLOBY_RS07880	COG0494	nUDIX hydrolase
CLOBY_RS07885	COG3546	catalase activity
CLOBY_RS07900	COG1051	belongs to the nudix hydrolase family
CLOBY_RS07900	COG1056	cytidyltransferase-related domain
CLOBY_RS07925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOBY_RS07940	COG0517	IMP dehydrogenase activity
CLOBY_RS07960	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOBY_RS07965	COG1879	ABC-type sugar transport system periplasmic component
CLOBY_RS07970	COG1609	Transcriptional regulator
CLOBY_RS08030	COG0242	peptide deformylase activity
CLOBY_RS08080	COG0493	'glutamate synthase
CLOBY_RS08090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLOBY_RS08100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOBY_RS08155	COG3963	phosphatidate phosphatase activity
CLOBY_RS08180	COG2205	protein histidine kinase activity
CLOBY_RS08185	COG1309	transcriptional regulator
CLOBY_RS08190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOBY_RS08195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLOBY_RS08200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLOBY_RS08205	COG1882	Formate acetyltransferase
CLOBY_RS08235	COG3189	MarR family transcriptional regulator
CLOBY_RS08260	COG0789	Transcriptional regulator
CLOBY_RS08270	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CLOBY_RS08275	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CLOBY_RS08315	COG2177	Part of the ABC transporter FtsEX involved in
CLOBY_RS08335	COG1879	ABC-type sugar transport system periplasmic component
CLOBY_RS08365	COG0798	PFAM Bile acid sodium symporter
CLOBY_RS08385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLOBY_RS08390	COG0659	secondary active sulfate transmembrane transporter activity
CLOBY_RS08395	COG2226	methyltransferase
CLOBY_RS08410	COG2199	diguanylate cyclase activity
CLOBY_RS08410	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOBY_RS08420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOBY_RS08425	COG2207	Transcriptional regulator
CLOBY_RS08430	COG1169	isochorismate synthase
CLOBY_RS08445	COG2091	lysine biosynthetic process via aminoadipic acid
CLOBY_RS08450	COG1021	2,3-dihydroxybenzoate-AMP ligase
CLOBY_RS08455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLOBY_RS08455	COG2226	methyltransferase
CLOBY_RS08455	COG3433	isochorismatase activity
CLOBY_RS08460	COG2226	methyltransferase
CLOBY_RS08460	COG3433	isochorismatase activity
CLOBY_RS08460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLOBY_RS08490	COG1129	ABC transporter
CLOBY_RS08495	COG2375	cellular response to nickel ion
CLOBY_RS08495	COG1132	(ABC) transporter
CLOBY_RS08500	COG1132	(ABC) transporter
CLOBY_RS08510	COG0840	transmembrane signaling receptor activity
CLOBY_RS08545	COG2207	Transcriptional regulator
CLOBY_RS08560	COG2132	Multicopper oxidase
CLOBY_RS08565	COG1342	Belongs to the UPF0251 family
CLOBY_RS08625	COG4974	Belongs to the 'phage' integrase family
CLOBY_RS08750	COG0740	serine-type endopeptidase activity
CLOBY_RS08820	COG3299	homolog of phage Mu protein gp47
CLOBY_RS08850	COG5492	domain, Protein
CLOBY_RS08870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLOBY_RS08880	COG0440	acetolactate synthase activity
CLOBY_RS08885	COG0028	Belongs to the TPP enzyme family
CLOBY_RS08905	COG1329	Transcriptional regulator
CLOBY_RS08910	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLOBY_RS08930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOBY_RS08935	COG5002	protein histidine kinase activity
CLOBY_RS08940	COG2273	Hydrolase Family 16
CLOBY_RS08945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOBY_RS08970	COG0701	Predicted permease
CLOBY_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
CLOBY_RS09015	COG0697	spore germination
CLOBY_RS09020	COG0561	phosphatase activity
CLOBY_RS09025	COG0310	cobalt ion transport
CLOBY_RS09035	COG1122	ATPase activity
CLOBY_RS09045	COG1606	tRNA processing
CLOBY_RS09050	COG1691	(AIR) carboxylase
CLOBY_RS09065	COG0024	Methionine aminopeptidase
CLOBY_RS09070	COG0514	ATP-dependent DNA helicase (RecQ)
CLOBY_RS09075	COG0484	heat shock protein binding
CLOBY_RS09080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLOBY_RS09085	COG1191	sigma factor activity
CLOBY_RS09090	COG3693	PFAM glycoside hydrolase, family 10
CLOBY_RS09095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLOBY_RS09095	COG0646	methionine synthase
CLOBY_RS09100	COG0493	'glutamate synthase
CLOBY_RS09105	COG0531	amino acid
CLOBY_RS09120	COG2217	Heavy metal translocating P-type atpase
CLOBY_RS09130	COG2814	Major facilitator Superfamily
CLOBY_RS09140	COG2267	carboxylic ester hydrolase activity
CLOBY_RS09145	COG0583	DNA-binding transcription factor activity
CLOBY_RS09155	COG0436	Aminotransferase
CLOBY_RS09165	COG3711	transcriptional antiterminator
CLOBY_RS09170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOBY_RS09170	COG1263	PTS System
CLOBY_RS09170	COG2190	(PTS) system
CLOBY_RS09180	COG1802	Transcriptional regulator
CLOBY_RS09185	COG0523	cobalamin synthesis protein
CLOBY_RS09205	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLOBY_RS09215	COG0789	Transcriptional regulator
CLOBY_RS09220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLOBY_RS09225	COG3976	FMN-binding domain protein
CLOBY_RS09225	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CLOBY_RS09245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLOBY_RS09255	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLOBY_RS09255	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLOBY_RS09265	COG3414	Phosphotransferase system galactitol-specific IIB component
CLOBY_RS09270	COG3775	system Galactitol-specific IIC component
CLOBY_RS09275	COG0371	Dehydrogenase
CLOBY_RS09290	COG0477	Major facilitator Superfamily
CLOBY_RS09300	COG0840	transmembrane signaling receptor activity
CLOBY_RS09320	COG0840	transmembrane signaling receptor activity
CLOBY_RS09320	COG5278	phosphoserine phosphatase activity
CLOBY_RS09325	COG0778	Nitroreductase
CLOBY_RS09330	COG0840	transmembrane signaling receptor activity
CLOBY_RS09340	COG2207	Transcriptional regulator
CLOBY_RS09350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLOBY_RS09355	COG2375	cellular response to nickel ion
CLOBY_RS09355	COG1132	(ABC) transporter
CLOBY_RS09360	COG1132	(ABC) transporter
CLOBY_RS09370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOBY_RS09375	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLOBY_RS09375	COG3608	succinylglutamate desuccinylase aspartoacylase
CLOBY_RS09395	COG1924	4 iron, 4 sulfur cluster binding
CLOBY_RS09420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLOBY_RS09420	COG2080	2 iron, 2 sulfur cluster binding
CLOBY_RS09425	COG3608	succinylglutamate desuccinylase aspartoacylase
CLOBY_RS09425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLOBY_RS09430	COG3328	transposase activity
CLOBY_RS09485	COG0346	lactoylglutathione lyase activity
CLOBY_RS09490	COG2205	protein histidine kinase activity
CLOBY_RS09490	COG4191	Histidine kinase
CLOBY_RS09490	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS09495	COG1960	acyl-CoA dehydrogenase activity
CLOBY_RS09500	COG0426	domain, Protein
CLOBY_RS09505	COG1393	Belongs to the ArsC family
CLOBY_RS09520	COG0494	nUDIX hydrolase
CLOBY_RS09530	COG1027	Aspartate ammonia-lyase
CLOBY_RS09535	COG1160	GTP binding
CLOBY_RS09590	COG1113	amino acid transport
CLOBY_RS09600	COG1695	Transcriptional regulator
CLOBY_RS09610	COG0840	transmembrane signaling receptor activity
CLOBY_RS09620	COG1472	Belongs to the glycosyl hydrolase 3 family
CLOBY_RS09630	COG0840	transmembrane signaling receptor activity
CLOBY_RS09635	COG2521	methyltransferase
CLOBY_RS09635	COG2136	Putative SAM-dependent methyltransferase
CLOBY_RS09650	COG0840	transmembrane signaling receptor activity
CLOBY_RS09655	COG0367	asparagine synthase
CLOBY_RS09660	COG0004	ammonium transporteR
CLOBY_RS09690	COG1846	Transcriptional regulator
CLOBY_RS09725	COG2086	electron transfer activity
CLOBY_RS09730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOBY_RS09735	COG1620	l-lactate permease
CLOBY_RS09745	COG1960	acyl-CoA dehydrogenase activity
CLOBY_RS09750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOBY_RS09760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOBY_RS09770	COG1695	Transcriptional regulator
CLOBY_RS09780	COG0488	(ABC) transporter
CLOBY_RS09790	COG0667	Aldo Keto reductase
CLOBY_RS09815	COG0556	nucleotide-excision repair
CLOBY_RS09850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CLOBY_RS09875	COG4974	Belongs to the 'phage' integrase family
CLOBY_RS09905	COG0824	Thioesterase
CLOBY_RS09915	COG0840	transmembrane signaling receptor activity
CLOBY_RS09930	COG2247	cell wall binding repeat
CLOBY_RS09930	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOBY_RS09940	COG0789	Transcriptional regulator
CLOBY_RS09940	COG4978	Transcriptional regulator
CLOBY_RS09945	COG1132	(ABC) transporter
CLOBY_RS09950	COG1132	(ABC) transporter
CLOBY_RS09965	COG1609	Transcriptional regulator
CLOBY_RS09975	COG2211	Major facilitator Superfamily
CLOBY_RS09980	COG1904	glucuronate isomerase
CLOBY_RS09985	COG0800	Aldolase
CLOBY_RS09990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOBY_RS09995	COG0246	Mannitol dehydrogenase
CLOBY_RS10000	COG2721	sulfolactate sulfo-lyase activity
CLOBY_RS10015	COG1695	Transcriptional regulator
CLOBY_RS10035	COG3328	transposase activity
CLOBY_RS10065	COG0840	transmembrane signaling receptor activity
CLOBY_RS10075	COG2223	nitrite transmembrane transporter activity
CLOBY_RS10080	COG3279	Response regulator of the LytR AlgR family
CLOBY_RS10085	COG3275	phosphorelay sensor kinase activity
CLOBY_RS10125	COG0534	Mate efflux family protein
CLOBY_RS10165	COG1595	DNA-templated transcription, initiation
CLOBY_RS10225	COG1309	transcriptional regulator
CLOBY_RS10230	COG1846	Transcriptional regulator
CLOBY_RS10235	COG0534	Mate efflux family protein
CLOBY_RS10240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLOBY_RS10245	COG0643	Histidine kinase
CLOBY_RS10245	COG2198	Histidine kinase
CLOBY_RS10250	COG2201	protein-glutamate methylesterase activity
CLOBY_RS10255	COG0835	chemotaxis
CLOBY_RS10265	COG0577	efflux transmembrane transporter activity
CLOBY_RS10265	COG1136	(ABC) transporter
CLOBY_RS10275	COG1136	(ABC) transporter
CLOBY_RS10290	COG1136	(ABC) transporter
CLOBY_RS10300	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS10305	COG2202	Pas domain
CLOBY_RS10305	COG2205	protein histidine kinase activity
CLOBY_RS10345	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS10365	COG2205	protein histidine kinase activity
CLOBY_RS10380	COG2207	Transcriptional regulator
CLOBY_RS10380	COG1917	Cupin 2, conserved barrel domain protein
CLOBY_RS10385	COG0697	spore germination
CLOBY_RS10395	COG0488	(ABC) transporter
CLOBY_RS10405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLOBY_RS10410	COG3706	GGDEF domain
CLOBY_RS10420	COG0835	chemotaxis
CLOBY_RS10425	COG2201	protein-glutamate methylesterase activity
CLOBY_RS10435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLOBY_RS10440	COG2201	protein-glutamate methylesterase activity
CLOBY_RS10445	COG0643	Histidine kinase
CLOBY_RS10445	COG2198	Histidine kinase
CLOBY_RS10450	COG2201	protein-glutamate methylesterase activity
CLOBY_RS10465	COG1366	Belongs to the anti-sigma-factor antagonist family
CLOBY_RS10470	COG1366	Belongs to the anti-sigma-factor antagonist family
CLOBY_RS10475	COG2172	sigma factor antagonist activity
CLOBY_RS10485	COG3852	Histidine kinase
CLOBY_RS10490	COG2198	Histidine kinase
CLOBY_RS10490	COG0643	Histidine kinase
CLOBY_RS10505	COG1192	Involved in chromosome partitioning
CLOBY_RS10510	COG0835	chemotaxis
CLOBY_RS10515	COG2201	protein-glutamate methylesterase activity
CLOBY_RS10520	COG3328	transposase activity
CLOBY_RS10535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLOBY_RS10535	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLOBY_RS10540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOBY_RS10540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOBY_RS10545	COG3715	PTS system
CLOBY_RS10550	COG3716	PTS system mannose fructose sorbose family IID component
CLOBY_RS10555	COG1349	DNA-binding transcription factor activity
CLOBY_RS10560	COG1105	Belongs to the carbohydrate kinase PfkB family
CLOBY_RS10565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOBY_RS10565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOBY_RS10565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOBY_RS10590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLOBY_RS10605	COG1131	(ABC) transporter
CLOBY_RS10620	COG1307	EDD domain protein, DegV family
CLOBY_RS10630	COG2081	HI0933 family
CLOBY_RS10635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLOBY_RS10640	COG0539	negative regulation of cytoplasmic translation
CLOBY_RS10640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOBY_RS10660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOBY_RS10685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLOBY_RS10690	COG4974	Belongs to the 'phage' integrase family
CLOBY_RS10710	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLOBY_RS10715	COG1923	regulation of RNA biosynthetic process
CLOBY_RS10720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLOBY_RS10725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLOBY_RS10760	COG2086	electron transfer activity
CLOBY_RS10765	COG1960	acyl-CoA dehydrogenase activity
CLOBY_RS10785	COG2252	PERMEase
CLOBY_RS10795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOBY_RS10800	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CLOBY_RS10825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLOBY_RS10830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLOBY_RS10835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLOBY_RS10845	COG1012	belongs to the aldehyde dehydrogenase family
CLOBY_RS10850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLOBY_RS10860	COG0730	response to heat
CLOBY_RS10875	COG1396	sequence-specific DNA binding
CLOBY_RS10955	COG3299	homolog of phage Mu protein gp47
CLOBY_RS10975	COG0791	NLP P60 protein
CLOBY_RS11085	COG2201	protein-glutamate methylesterase activity
CLOBY_RS11090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLOBY_RS11100	COG2198	Histidine kinase
CLOBY_RS11100	COG0643	Histidine kinase
CLOBY_RS11105	COG0835	chemotaxis
CLOBY_RS11110	COG2201	protein-glutamate methylesterase activity
CLOBY_RS11115	COG5002	protein histidine kinase activity
CLOBY_RS11140	COG2608	mercury ion transmembrane transporter activity
CLOBY_RS11155	COG2217	Heavy metal translocating P-type atpase
CLOBY_RS11160	COG5002	protein histidine kinase activity
CLOBY_RS11165	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS11175	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOBY_RS11185	COG1285	pathogenesis
CLOBY_RS11200	COG0488	(ABC) transporter
CLOBY_RS11225	COG1268	BioY protein
CLOBY_RS11240	COG0159	tryptophan synthase activity
CLOBY_RS11245	COG0133	tryptophan synthase activity
CLOBY_RS11250	COG0135	phosphoribosylanthranilate isomerase activity
CLOBY_RS11255	COG0134	indole-3-glycerol-phosphate synthase activity
CLOBY_RS11260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLOBY_RS11265	COG0512	Glutamine amidotransferase of anthranilate synthase
CLOBY_RS11265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLOBY_RS11275	COG1959	2 iron, 2 sulfur cluster binding
CLOBY_RS11290	COG0406	alpha-ribazole phosphatase activity
CLOBY_RS11320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLOBY_RS11325	COG0346	lactoylglutathione lyase activity
CLOBY_RS11335	COG0306	phosphate transporter
CLOBY_RS11340	COG1392	Phosphate transport regulator
CLOBY_RS11370	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOBY_RS11375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLOBY_RS11390	COG0561	phosphatase activity
CLOBY_RS11425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOBY_RS11440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLOBY_RS11445	COG0561	phosphatase activity
CLOBY_RS11450	COG1349	DNA-binding transcription factor activity
CLOBY_RS11455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLOBY_RS11460	COG0840	transmembrane signaling receptor activity
CLOBY_RS11470	COG0789	Transcriptional regulator
CLOBY_RS11470	COG4978	Transcriptional regulator
CLOBY_RS11475	COG0534	Mate efflux family protein
CLOBY_RS11485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLOBY_RS11485	COG1773	rubredoxin
CLOBY_RS11495	COG1113	amino acid transport
CLOBY_RS11505	COG3639	organic phosphonate transmembrane transporter activity
CLOBY_RS11515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLOBY_RS11535	COG2201	protein-glutamate methylesterase activity
CLOBY_RS11545	COG0840	transmembrane signaling receptor activity
CLOBY_RS11550	COG0835	chemotaxis
CLOBY_RS11555	COG2198	Histidine kinase
CLOBY_RS11555	COG0643	Histidine kinase
CLOBY_RS11560	COG2201	protein-glutamate methylesterase activity
CLOBY_RS11565	COG0840	transmembrane signaling receptor activity
CLOBY_RS11570	COG2814	Major facilitator Superfamily
CLOBY_RS11580	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOBY_RS11605	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CLOBY_RS11610	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOBY_RS11615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLOBY_RS11620	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOBY_RS11625	COG1802	Transcriptional regulator
CLOBY_RS11630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLOBY_RS11660	COG2226	methyltransferase
CLOBY_RS11665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOBY_RS11675	COG1113	amino acid transport
CLOBY_RS11705	COG1131	(ABC) transporter
CLOBY_RS11720	COG1131	(ABC) transporter
CLOBY_RS11735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLOBY_RS11740	COG1116	anion transmembrane transporter activity
CLOBY_RS11745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLOBY_RS11750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOBY_RS11760	COG0084	hydrolase, TatD family'
CLOBY_RS11770	COG5002	protein histidine kinase activity
CLOBY_RS11800	COG2814	Major facilitator Superfamily
CLOBY_RS11805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLOBY_RS11810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOBY_RS11815	COG0833	amino acid
CLOBY_RS11825	COG2040	homocysteine
CLOBY_RS11865	COG2962	Rard protein
CLOBY_RS11870	COG0697	spore germination
CLOBY_RS11890	COG0367	asparagine synthase
CLOBY_RS11895	COG5002	protein histidine kinase activity
CLOBY_RS11905	COG0840	transmembrane signaling receptor activity
CLOBY_RS11915	COG1335	isochorismatase
CLOBY_RS11935	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CLOBY_RS11995	COG0477	Major facilitator Superfamily
CLOBY_RS12005	COG1733	regulation of RNA biosynthetic process
CLOBY_RS12020	COG3148	PFAM DTW domain containing protein
CLOBY_RS12035	COG0352	thiamine-phosphate diphosphorylase activity
CLOBY_RS12045	COG2022	thiamine diphosphate biosynthetic process
CLOBY_RS12050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLOBY_RS12060	COG3875	lactate racemase activity
CLOBY_RS12065	COG3546	catalase activity
CLOBY_RS12075	COG0657	acetylesterase activity
CLOBY_RS12080	COG1902	pentaerythritol trinitrate reductase activity
CLOBY_RS12080	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOBY_RS12085	COG0543	2 iron, 2 sulfur cluster binding
CLOBY_RS12090	COG0583	DNA-binding transcription factor activity
CLOBY_RS12095	COG0826	peptidase U32
CLOBY_RS12100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOBY_RS12105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOBY_RS12115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOBY_RS12120	COG0583	DNA-binding transcription factor activity
CLOBY_RS12125	COG0406	alpha-ribazole phosphatase activity
CLOBY_RS12140	COG0583	DNA-binding transcription factor activity
CLOBY_RS12145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOBY_RS12150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOBY_RS12160	COG1408	metallophosphoesterase
CLOBY_RS12165	COG2909	trisaccharide binding
CLOBY_RS12180	COG1131	(ABC) transporter
CLOBY_RS12210	COG1733	regulation of RNA biosynthetic process
CLOBY_RS12235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLOBY_RS12255	COG0110	maltose O-acetyltransferase activity
CLOBY_RS12275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLOBY_RS12280	COG2207	Transcriptional regulator
CLOBY_RS12280	COG3708	Transcriptional regulator
CLOBY_RS12305	COG0477	Major facilitator Superfamily
CLOBY_RS12310	COG1309	transcriptional regulator
CLOBY_RS12325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOBY_RS12330	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS12330	COG2205	protein histidine kinase activity
CLOBY_RS12330	COG3292	Two component regulator propeller
CLOBY_RS12350	COG0791	NLP P60 protein
CLOBY_RS12355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLOBY_RS12375	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLOBY_RS12380	COG0840	transmembrane signaling receptor activity
CLOBY_RS12410	COG0494	nUDIX hydrolase
CLOBY_RS12415	COG4708	membrane
CLOBY_RS12420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOBY_RS12425	COG1199	ATP-dependent helicase activity
CLOBY_RS12425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLOBY_RS12445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOBY_RS12445	COG0551	DNA topoisomerase type I activity
CLOBY_RS12475	COG2909	trisaccharide binding
CLOBY_RS12480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLOBY_RS12485	COG0583	DNA-binding transcription factor activity
CLOBY_RS12535	COG0768	penicillin binding
CLOBY_RS12540	COG0346	lactoylglutathione lyase activity
CLOBY_RS12555	COG1737	Transcriptional regulator
CLOBY_RS12560	COG1187	pseudouridine synthase activity
CLOBY_RS12575	COG0531	amino acid
CLOBY_RS12605	COG0445	tRNA wobble uridine modification
CLOBY_RS12610	COG1686	Belongs to the peptidase S11 family
CLOBY_RS12620	COG3874	Sporulation protein YtfJ
CLOBY_RS12625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLOBY_RS12635	COG1686	Belongs to the peptidase S11 family
CLOBY_RS12640	COG1910	domain protein
CLOBY_RS12645	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLOBY_RS12650	COG4149	molybdate abc transporter
CLOBY_RS12655	COG3842	ATPase activity
CLOBY_RS12665	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLOBY_RS12690	COG0303	'Molybdopterin
CLOBY_RS12695	COG1058	Belongs to the CinA family
CLOBY_RS12695	COG1546	Belongs to the CinA family
CLOBY_RS12720	COG0243	molybdopterin cofactor binding
CLOBY_RS12745	COG2223	nitrite transmembrane transporter activity
CLOBY_RS12750	COG4974	Belongs to the 'phage' integrase family
CLOBY_RS12805	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS12810	COG0750	zinc metalloprotease
CLOBY_RS12820	COG1438	arginine binding
CLOBY_RS12825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLOBY_RS12830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLOBY_RS12835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLOBY_RS12840	COG0142	geranyltranstransferase activity
CLOBY_RS12845	COG1722	exodeoxyribonuclease VII activity
CLOBY_RS12850	COG1570	exodeoxyribonuclease VII activity
CLOBY_RS12855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLOBY_RS12860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOBY_RS12865	COG1302	Protein conserved in bacteria
CLOBY_RS12905	COG3854	ATPases associated with a variety of cellular activities
CLOBY_RS12980	COG4974	Belongs to the 'phage' integrase family
CLOBY_RS12995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLOBY_RS13035	COG1045	serine acetyltransferase
CLOBY_RS13055	COG3299	homolog of phage Mu protein gp47
CLOBY_RS13070	COG0791	NLP P60 protein
CLOBY_RS13235	COG0037	tRNA processing
CLOBY_RS13275	COG2002	toxin-antitoxin pair type II binding
CLOBY_RS13290	COG1396	sequence-specific DNA binding
CLOBY_RS13305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLOBY_RS13340	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CLOBY_RS13345	COG1737	Transcriptional regulator
CLOBY_RS13350	COG0116	Belongs to the methyltransferase superfamily
CLOBY_RS13355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLOBY_RS13360	COG0564	pseudouridine synthase activity
CLOBY_RS13365	COG3599	regulation of cell shape
CLOBY_RS13370	COG2302	S4 RNA-binding domain
CLOBY_RS13380	COG1799	cell septum assembly
CLOBY_RS13385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLOBY_RS13395	COG3856	small basic protein
CLOBY_RS13410	COG0772	Belongs to the SEDS family
CLOBY_RS13415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOBY_RS13420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLOBY_RS13430	COG0768	penicillin binding
CLOBY_RS13440	COG0275	rRNA processing
CLOBY_RS13465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOBY_RS13470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLOBY_RS13505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLOBY_RS13510	COG2226	methyltransferase
CLOBY_RS13520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLOBY_RS13540	COG3123	guanosine phosphorylase activity
CLOBY_RS13545	COG0436	Aminotransferase
CLOBY_RS13550	COG2171	N-acyltransferase activity
CLOBY_RS13590	COG0861	Integral membrane protein TerC family
CLOBY_RS13615	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLOBY_RS13645	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLOBY_RS13660	COG4632	Exopolysaccharide biosynthesis protein
CLOBY_RS13660	COG5434	Belongs to the glycosyl hydrolase 28 family
CLOBY_RS13665	COG0534	Mate efflux family protein
CLOBY_RS13675	COG4632	Exopolysaccharide biosynthesis protein
CLOBY_RS13675	COG5434	Belongs to the glycosyl hydrolase 28 family
CLOBY_RS13695	COG2137	regulation of response to DNA damage stimulus
CLOBY_RS13700	COG0612	Peptidase, M16
CLOBY_RS13705	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS13710	COG5002	protein histidine kinase activity
CLOBY_RS13715	COG0252	asparaginase activity
CLOBY_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
CLOBY_RS13735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLOBY_RS13740	COG2966	Psort location CytoplasmicMembrane, score
CLOBY_RS13765	COG2801	Transposase and inactivated derivatives
CLOBY_RS13785	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLOBY_RS13805	COG1187	pseudouridine synthase activity
CLOBY_RS13820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLOBY_RS13825	COG0183	Belongs to the thiolase family
CLOBY_RS13830	COG1268	BioY protein
CLOBY_RS13840	COG0488	(ABC) transporter
CLOBY_RS13855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLOBY_RS13860	COG0840	transmembrane signaling receptor activity
CLOBY_RS13865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLOBY_RS13870	COG0572	uridine kinase
CLOBY_RS13880	COG1329	Transcriptional regulator
CLOBY_RS13890	COG2271	Major facilitator Superfamily
CLOBY_RS13900	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOBY_RS13910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLOBY_RS13915	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CLOBY_RS13920	COG5002	protein histidine kinase activity
CLOBY_RS13930	COG0460	homoserine dehydrogenase
CLOBY_RS13945	COG1132	(ABC) transporter
CLOBY_RS13950	COG1404	Belongs to the peptidase S8 family
CLOBY_RS13980	COG0489	protein tyrosine kinase activity
CLOBY_RS13995	COG1091	dTDP-4-dehydrorhamnose reductase activity
CLOBY_RS14060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLOBY_RS14070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOBY_RS14075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOBY_RS14080	COG1490	D-aminoacyl-tRNA deacylase activity
CLOBY_RS14085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLOBY_RS14090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOBY_RS14095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLOBY_RS14095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLOBY_RS14100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLOBY_RS14105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLOBY_RS14125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLOBY_RS14130	COG2255	four-way junction helicase activity
CLOBY_RS14135	COG0632	four-way junction helicase activity
CLOBY_RS14150	COG0583	DNA-binding transcription factor activity
CLOBY_RS14155	COG0281	malic enzyme
CLOBY_RS14160	COG0471	metal ion transport
CLOBY_RS14180	COG0586	Pfam SNARE associated Golgi protein
CLOBY_RS14185	COG0671	phosphoesterase, PA-phosphatase related
CLOBY_RS14190	COG5002	protein histidine kinase activity
CLOBY_RS14195	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS14200	COG5577	PFAM Coat F domain
CLOBY_RS14210	COG1063	alcohol dehydrogenase
CLOBY_RS14215	COG5577	PFAM Coat F domain
CLOBY_RS14225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CLOBY_RS14255	COG1595	DNA-templated transcription, initiation
CLOBY_RS14260	COG0723	plastoquinol--plastocyanin reductase activity
CLOBY_RS14260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLOBY_RS14265	COG0024	Methionine aminopeptidase
CLOBY_RS14270	COG1395	domain, Protein
CLOBY_RS14275	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOBY_RS14280	COG1253	flavin adenine dinucleotide binding
CLOBY_RS14285	COG0501	Belongs to the peptidase M48B family
CLOBY_RS14310	COG0647	UMP catabolic process
CLOBY_RS14325	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLOBY_RS14330	COG1592	Rubrerythrin
CLOBY_RS14330	COG1773	rubredoxin
CLOBY_RS14340	COG0484	heat shock protein binding
CLOBY_RS14360	COG0531	amino acid
CLOBY_RS14370	COG1362	aminopeptidase activity
CLOBY_RS14375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLOBY_RS14425	COG1410	methionine synthase
CLOBY_RS14425	COG0646	methionine synthase
CLOBY_RS14440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOBY_RS14465	COG1527	subunit (C
CLOBY_RS14475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOBY_RS14480	COG1269	ATP hydrolysis coupled proton transport
CLOBY_RS14490	COG0439	Biotin carboxylase
CLOBY_RS14495	COG0511	ligase activity, forming carbon-carbon bonds
CLOBY_RS14500	COG1984	allophanate hydrolase subunit 2
CLOBY_RS14505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CLOBY_RS14515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CLOBY_RS14520	COG4336	lyase activity
CLOBY_RS14535	COG1522	sequence-specific DNA binding
CLOBY_RS14550	COG0038	chloride channel
CLOBY_RS14555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLOBY_RS14575	COG2244	polysaccharide biosynthetic process
CLOBY_RS14580	COG0564	pseudouridine synthase activity
CLOBY_RS14585	COG1473	amidohydrolase
CLOBY_RS14590	COG0849	cell division
CLOBY_RS14600	COG0210	DNA helicase
CLOBY_RS14605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLOBY_RS14620	COG0735	belongs to the Fur family
CLOBY_RS14650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLOBY_RS14655	COG1067	ATP-dependent peptidase activity
CLOBY_RS14655	COG0470	DNA polymerase III
CLOBY_RS14660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLOBY_RS14670	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLOBY_RS14685	COG0140	phosphoribosyl-ATP diphosphatase activity
CLOBY_RS14690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLOBY_RS14695	COG0107	imidazoleglycerol-phosphate synthase activity
CLOBY_RS14700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLOBY_RS14705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLOBY_RS14710	COG0131	Imidazoleglycerol-phosphate dehydratase
CLOBY_RS14715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOBY_RS14720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLOBY_RS14725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLOBY_RS14770	COG1595	DNA-templated transcription, initiation
CLOBY_RS14775	COG1301	dicarboxylic acid transport
CLOBY_RS14780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOBY_RS14795	COG4492	Belongs to the UPF0735 family
CLOBY_RS14800	COG0083	homoserine kinase activity
CLOBY_RS14805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLOBY_RS14825	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLOBY_RS14835	COG1376	ErfK ybiS ycfS ynhG family protein
CLOBY_RS14840	COG3850	Histidine kinase
CLOBY_RS14840	COG5002	protein histidine kinase activity
CLOBY_RS14870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLOBY_RS14875	COG0113	porphobilinogen synthase activity
CLOBY_RS14885	COG0181	hydroxymethylbilane synthase activity
CLOBY_RS14895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLOBY_RS14955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLOBY_RS14965	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLOBY_RS14970	COG2706	6-phosphogluconolactonase activity
CLOBY_RS14975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOBY_RS14985	COG0561	phosphatase activity
CLOBY_RS14990	COG0673	inositol 2-dehydrogenase activity
CLOBY_RS15010	COG1492	cobalamin metabolic process
CLOBY_RS15015	COG0482	sulfurtransferase activity
CLOBY_RS15020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOBY_RS15040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLOBY_RS15060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLOBY_RS15080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CLOBY_RS15095	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLOBY_RS15100	COG2099	Precorrin-6x reductase
CLOBY_RS15115	COG4565	transcriptional regulatory protein
CLOBY_RS15120	COG3290	protein histidine kinase activity
CLOBY_RS15125	COG3426	butyrate kinase activity
CLOBY_RS15135	COG0281	malic enzyme
CLOBY_RS15155	COG3885	ferrous iron binding
CLOBY_RS15155	COG2078	PFAM AMMECR1 domain protein
CLOBY_RS15165	COG3158	transport of potassium into the cell
CLOBY_RS15190	COG1609	Transcriptional regulator
CLOBY_RS15205	COG5002	protein histidine kinase activity
CLOBY_RS15210	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS15220	COG1704	LemA family
CLOBY_RS15230	COG0598	Magnesium transport protein CorA
CLOBY_RS15255	COG1648	precorrin-2 dehydrogenase activity
CLOBY_RS15255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLOBY_RS15260	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLOBY_RS15305	COG0428	transporter
CLOBY_RS15340	COG5002	protein histidine kinase activity
CLOBY_RS15360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOBY_RS15365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOBY_RS15370	COG4604	ABC transporter, ATP-binding protein
CLOBY_RS15380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLOBY_RS15385	COG0583	DNA-binding transcription factor activity
CLOBY_RS15395	COG0310	cobalt ion transport
CLOBY_RS15400	COG1122	ATPase activity
CLOBY_RS15410	COG1228	amidohydrolase
CLOBY_RS15450	COG3279	Response regulator of the LytR AlgR family
CLOBY_RS15460	COG4864	UPF0365 protein
CLOBY_RS15475	COG0583	DNA-binding transcription factor activity
CLOBY_RS15480	COG0697	spore germination
CLOBY_RS15500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLOBY_RS15510	COG1940	carbohydrate kinase activity
CLOBY_RS15525	COG2323	membrane
CLOBY_RS15540	COG2323	membrane
CLOBY_RS15550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOBY_RS15570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOBY_RS15580	COG1879	ABC-type sugar transport system periplasmic component
CLOBY_RS15615	COG0347	Belongs to the P(II) protein family
CLOBY_RS15620	COG3328	transposase activity
CLOBY_RS15635	COG4177	L-phenylalanine transmembrane transporter activity
CLOBY_RS15660	COG4177	L-phenylalanine transmembrane transporter activity
CLOBY_RS15705	COG2323	membrane
CLOBY_RS15745	COG1396	sequence-specific DNA binding
CLOBY_RS15750	COG0697	spore germination
CLOBY_RS15760	COG1136	(ABC) transporter
CLOBY_RS15765	COG0598	Magnesium transport protein CorA
CLOBY_RS15785	COG3104	oligopeptide transport
CLOBY_RS15795	COG0706	membrane insertase activity
CLOBY_RS15805	COG1742	UPF0060 membrane protein
CLOBY_RS15825	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLOBY_RS15835	COG4689	acetoacetate decarboxylase
CLOBY_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
CLOBY_RS15865	COG5002	protein histidine kinase activity
CLOBY_RS15865	COG3850	Histidine kinase
CLOBY_RS15870	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS15875	COG1114	Component of the transport system for branched-chain amino acids
CLOBY_RS15925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOBY_RS15930	COG1011	Hydrolase
CLOBY_RS15955	COG1131	(ABC) transporter
CLOBY_RS15960	COG1725	Transcriptional regulator
CLOBY_RS15980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLOBY_RS15985	COG2733	membrane
CLOBY_RS16005	COG4974	Belongs to the 'phage' integrase family
CLOBY_RS16025	COG2217	Heavy metal translocating P-type atpase
CLOBY_RS16045	COG0840	transmembrane signaling receptor activity
CLOBY_RS16045	COG3290	protein histidine kinase activity
CLOBY_RS16055	COG2814	Major facilitator Superfamily
CLOBY_RS16080	COG0840	transmembrane signaling receptor activity
CLOBY_RS16110	COG1309	transcriptional regulator
CLOBY_RS16120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOBY_RS16130	COG3647	Membrane
CLOBY_RS16145	COG1028	Short-chain dehydrogenase reductase Sdr
CLOBY_RS16210	COG0454	-acetyltransferase
CLOBY_RS16225	COG0477	Major facilitator Superfamily
CLOBY_RS16240	COG0789	Transcriptional regulator
CLOBY_RS16250	COG0406	alpha-ribazole phosphatase activity
CLOBY_RS16265	COG0456	acetyltransferase
CLOBY_RS16270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLOBY_RS16310	COG0346	lactoylglutathione lyase activity
CLOBY_RS16415	COG0281	malic enzyme
CLOBY_RS16420	COG0493	'glutamate synthase
CLOBY_RS16425	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLOBY_RS16430	COG0569	domain protein
CLOBY_RS16430	COG2985	domain, Protein
CLOBY_RS16435	COG2828	Protein conserved in bacteria
CLOBY_RS16440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOBY_RS16450	COG3051	citrate lyase alpha subunit
CLOBY_RS16460	COG3052	prosthetic group binding
CLOBY_RS16465	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CLOBY_RS16470	COG1802	Transcriptional regulator
CLOBY_RS16480	COG1113	amino acid transport
CLOBY_RS16510	COG0662	Cupin 2, conserved barrel domain protein
CLOBY_RS16515	COG0840	transmembrane signaling receptor activity
CLOBY_RS16535	COG0534	Mate efflux family protein
CLOBY_RS16565	COG0840	transmembrane signaling receptor activity
CLOBY_RS16565	COG5278	phosphoserine phosphatase activity
CLOBY_RS16650	COG5278	phosphoserine phosphatase activity
CLOBY_RS16650	COG0840	transmembrane signaling receptor activity
CLOBY_RS16660	COG0840	transmembrane signaling receptor activity
CLOBY_RS16700	COG3299	homolog of phage Mu protein gp47
CLOBY_RS16800	COG5484	DNA packaging
CLOBY_RS16800	COG3728	DNA packaging
CLOBY_RS16835	COG1484	DNA-dependent DNA replication
CLOBY_RS16870	COG1131	(ABC) transporter
CLOBY_RS16880	COG0840	transmembrane signaling receptor activity
CLOBY_RS16895	COG2207	Transcriptional regulator
CLOBY_RS16905	COG0789	Transcriptional regulator
CLOBY_RS16910	COG5504	Zn-dependent protease
CLOBY_RS16930	COG3866	Pectate lyase
CLOBY_RS16935	COG1335	isochorismatase
CLOBY_RS16940	COG1522	sequence-specific DNA binding
CLOBY_RS16945	COG0583	DNA-binding transcription factor activity
CLOBY_RS16950	COG1881	PFAM PEBP family protein
CLOBY_RS16955	COG0138	bifunctional purine biosynthesis protein purh
CLOBY_RS16960	COG2076	Multidrug Resistance protein
CLOBY_RS16995	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS17000	COG5002	protein histidine kinase activity
CLOBY_RS17035	COG1454	alcohol dehydrogenase
CLOBY_RS17055	COG3576	pyridoxamine 5-phosphate
CLOBY_RS17100	COG0583	DNA-binding transcription factor activity
CLOBY_RS17105	COG2855	membrane
CLOBY_RS17115	COG5002	protein histidine kinase activity
CLOBY_RS17120	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS17125	COG1216	Glycosyl transferase, family 2
CLOBY_RS17140	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOBY_RS17150	COG0693	protein deglycase activity
CLOBY_RS17155	COG2207	Transcriptional regulator
CLOBY_RS17155	COG4753	response regulator
CLOBY_RS17175	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOBY_RS17180	COG1129	ABC transporter
CLOBY_RS17205	COG5444	nuclease activity
CLOBY_RS17225	COG3547	Transposase (IS116 IS110 IS902 family)
CLOBY_RS17255	COG2801	Transposase and inactivated derivatives
CLOBY_RS17275	COG1131	(ABC) transporter
CLOBY_RS17285	COG1472	Belongs to the glycosyl hydrolase 3 family
CLOBY_RS17295	COG0840	transmembrane signaling receptor activity
CLOBY_RS17300	COG4753	response regulator
CLOBY_RS17300	COG2207	Transcriptional regulator
CLOBY_RS17305	COG4251	negative regulation of phosphorylation
CLOBY_RS17315	COG5002	protein histidine kinase activity
CLOBY_RS17350	COG1132	(ABC) transporter
CLOBY_RS17360	COG0583	DNA-binding transcription factor activity
CLOBY_RS17370	COG3655	Transcriptional regulator
CLOBY_RS17390	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CLOBY_RS17400	COG1733	regulation of RNA biosynthetic process
CLOBY_RS17410	COG0842	Transport permease protein
CLOBY_RS17415	COG1131	(ABC) transporter
CLOBY_RS17430	COG3300	MHYT domain
CLOBY_RS17430	COG5001	Diguanylate cyclase
CLOBY_RS17450	COG1132	(ABC) transporter
CLOBY_RS17470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLOBY_RS17495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOBY_RS17500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLOBY_RS17530	COG2340	Cysteine-rich secretory protein family
CLOBY_RS17570	COG0840	transmembrane signaling receptor activity
CLOBY_RS17600	COG1595	DNA-templated transcription, initiation
CLOBY_RS17605	COG1879	ABC-type sugar transport system periplasmic component
CLOBY_RS17625	COG2816	NAD+ diphosphatase activity
CLOBY_RS17630	COG0840	transmembrane signaling receptor activity
CLOBY_RS17680	COG2814	Major facilitator Superfamily
CLOBY_RS17690	COG0477	Major facilitator Superfamily
CLOBY_RS17705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOBY_RS17710	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS17715	COG5002	protein histidine kinase activity
CLOBY_RS17720	COG5599	Phosphatase
CLOBY_RS17745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOBY_RS17765	COG1846	Transcriptional regulator
CLOBY_RS17770	COG4106	trans-aconitate 2-methyltransferase activity
CLOBY_RS17810	COG0386	Belongs to the glutathione peroxidase family
CLOBY_RS17820	COG0531	amino acid
CLOBY_RS17855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOBY_RS17865	COG0583	DNA-binding transcription factor activity
CLOBY_RS17880	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CLOBY_RS17930	COG1151	hydroxylamine reductase activity
CLOBY_RS17950	COG0754	glutathionylspermidine amidase activity
CLOBY_RS17995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CLOBY_RS18005	COG2824	Alkylphosphonate utilization operon protein PhnA
CLOBY_RS18015	COG5002	protein histidine kinase activity
CLOBY_RS18025	COG0463	Glycosyl transferase, family 2
CLOBY_RS18030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLOBY_RS18035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOBY_RS18045	COG4302	ethanolamine ammonia-lyase activity
CLOBY_RS18050	COG4303	Ethanolamine ammonia lyase large subunit
CLOBY_RS18060	COG4819	ethanolamine utilization protein
CLOBY_RS18070	COG0840	transmembrane signaling receptor activity
CLOBY_RS18085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLOBY_RS18110	COG3958	Transketolase
CLOBY_RS18115	COG3959	Transketolase, thiamine diphosphate binding domain
CLOBY_RS18140	COG3037	sugar-specific permease SgaT UlaA
CLOBY_RS18155	COG1349	DNA-binding transcription factor activity
CLOBY_RS18160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLOBY_RS18165	COG2033	superoxide reductase activity
CLOBY_RS18175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOBY_RS18190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLOBY_RS18200	COG1523	belongs to the glycosyl hydrolase 13 family
CLOBY_RS18210	COG4086	secreted protein
CLOBY_RS18225	COG2267	carboxylic ester hydrolase activity
CLOBY_RS18245	COG0813	purine-nucleoside phosphorylase activity
CLOBY_RS18255	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOBY_RS18260	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOBY_RS18265	COG3845	ABC transporter
CLOBY_RS18270	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOBY_RS18280	COG0436	Aminotransferase
CLOBY_RS18285	COG1522	sequence-specific DNA binding
CLOBY_RS18295	COG0542	response to heat
CLOBY_RS18300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLOBY_RS18305	COG1982	Orn Lys Arg decarboxylase major
CLOBY_RS18315	COG0612	Peptidase, M16
CLOBY_RS18335	COG0326	Molecular chaperone. Has ATPase activity
CLOBY_RS18340	COG2199	diguanylate cyclase activity
CLOBY_RS18340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOBY_RS18350	COG1136	(ABC) transporter
CLOBY_RS18355	COG2205	protein histidine kinase activity
CLOBY_RS18360	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS18365	COG0840	transmembrane signaling receptor activity
CLOBY_RS18365	COG5278	phosphoserine phosphatase activity
CLOBY_RS18370	COG0840	transmembrane signaling receptor activity
CLOBY_RS18380	COG0175	sulfate reduction
CLOBY_RS18395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLOBY_RS18400	COG4208	sulfate ABC transporter
CLOBY_RS18410	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CLOBY_RS18435	COG0726	polysaccharide deacetylase
CLOBY_RS18455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLOBY_RS18470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLOBY_RS18480	COG4786	Flagellar basal body rod
CLOBY_RS18500	COG1191	sigma factor activity
CLOBY_RS18510	COG0455	bacterial-type flagellum organization
CLOBY_RS18515	COG1419	protein localization to endoplasmic reticulum
CLOBY_RS18520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOBY_RS18525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOBY_RS18535	COG1338	Plays a role in the flagellum-specific transport system
CLOBY_RS18550	COG1582	Flagellar protein (FlbD)
CLOBY_RS18555	COG4786	Flagellar basal body rod
CLOBY_RS18575	COG2882	bacterial-type flagellum organization
CLOBY_RS18580	COG1157	protein secretion by the type III secretion system
CLOBY_RS18590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOBY_RS18595	COG1766	The M ring may be actively involved in energy transduction
CLOBY_RS18600	COG1677	Flagellar hook-basal body complex protein FliE
CLOBY_RS18605	COG1558	bacterial-type flagellum-dependent cell motility
CLOBY_RS18610	COG1815	bacterial-type flagellum-dependent cell motility
CLOBY_RS18635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOBY_RS18640	COG1088	dTDP-glucose 4,6-dehydratase activity
CLOBY_RS18650	COG1086	Polysaccharide biosynthesis protein
CLOBY_RS18655	COG0463	Glycosyl transferase, family 2
CLOBY_RS18655	COG0457	Tetratricopeptide repeat
CLOBY_RS18660	COG2089	acid synthase
CLOBY_RS18670	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLOBY_RS18680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLOBY_RS18695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOBY_RS18705	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLOBY_RS18730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLOBY_RS18745	COG1334	flagellar protein FlaG
CLOBY_RS18750	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLOBY_RS18755	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLOBY_RS18765	COG1256	bacterial-type flagellum assembly
CLOBY_RS18765	COG4786	Flagellar basal body rod
CLOBY_RS18780	COG1776	CheC inhibitor of MCP methylation
CLOBY_RS18780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOBY_RS18785	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOBY_RS18795	COG2201	protein-glutamate methylesterase activity
CLOBY_RS18800	COG1776	CheC inhibitor of MCP methylation
CLOBY_RS18805	COG2198	Histidine kinase
CLOBY_RS18805	COG0643	Histidine kinase
CLOBY_RS18810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLOBY_RS18815	COG2201	protein-glutamate methylesterase activity
CLOBY_RS18845	COG0436	Aminotransferase
CLOBY_RS18860	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLOBY_RS18865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOBY_RS18870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLOBY_RS18870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLOBY_RS18880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOBY_RS18885	COG0187	DNA topoisomerase II activity
CLOBY_RS18900	COG0705	Rhomboid family
CLOBY_RS18900	COG0457	Tetratricopeptide repeat
CLOBY_RS18905	COG1164	Oligoendopeptidase f
CLOBY_RS18920	COG1121	(ABC) transporter
CLOBY_RS18925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLOBY_RS18935	COG1971	Probably functions as a manganese efflux pump
CLOBY_RS18940	COG0205	6-phosphofructokinase activity
CLOBY_RS18955	COG1309	transcriptional regulator
CLOBY_RS18960	COG0488	(ABC) transporter
CLOBY_RS18965	COG0756	dUTP diphosphatase activity
CLOBY_RS18975	COG0726	polysaccharide deacetylase
CLOBY_RS18995	COG0037	tRNA processing
CLOBY_RS19005	COG3191	aminopeptidase activity
CLOBY_RS19040	COG0437	4 iron, 4 sulfur cluster binding
CLOBY_RS19045	COG0243	molybdopterin cofactor binding
CLOBY_RS19050	COG1464	Belongs to the NlpA lipoprotein family
CLOBY_RS19055	COG2011	ABC-type metal ion transport system permease component
CLOBY_RS19065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLOBY_RS19070	COG0557	exoribonuclease II activity
CLOBY_RS19080	COG0148	phosphopyruvate hydratase activity
CLOBY_RS19095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLOBY_RS19100	COG0149	triose-phosphate isomerase activity
CLOBY_RS19105	COG0126	phosphoglycerate kinase activity
CLOBY_RS19115	COG2390	Transcriptional regulator
CLOBY_RS19120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLOBY_RS19130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLOBY_RS19135	COG2720	vancomycin resistance protein
CLOBY_RS19145	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOBY_RS19150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLOBY_RS19160	COG1045	serine acetyltransferase
CLOBY_RS19165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOBY_RS19170	COG2239	Acts as a magnesium transporter
CLOBY_RS19190	COG1597	lipid kinase activity
CLOBY_RS19195	COG1183	phosphatidylcholine synthase activity
CLOBY_RS19210	COG1592	Rubrerythrin
CLOBY_RS19215	COG2719	SpoVR family
CLOBY_RS19220	COG2718	Belongs to the UPF0229 family
CLOBY_RS19225	COG2766	serine protein kinase
CLOBY_RS19230	COG2814	Major facilitator Superfamily
CLOBY_RS19240	COG2201	protein-glutamate methylesterase activity
CLOBY_RS19245	COG0390	transport system, permease component
CLOBY_RS19250	COG2274	protein secretion by the type I secretion system
CLOBY_RS19255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLOBY_RS19260	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOBY_RS19260	COG0493	'glutamate synthase
CLOBY_RS19270	COG1063	alcohol dehydrogenase
CLOBY_RS19300	COG2205	protein histidine kinase activity
CLOBY_RS19305	COG0745	RESPONSE REGULATOR receiver
CLOBY_RS19315	COG2199	diguanylate cyclase activity
CLOBY_RS19315	COG2202	Pas domain
CLOBY_RS19315	COG2200	EAL domain
CLOBY_RS19320	COG4974	Belongs to the 'phage' integrase family
CLOBY_RS19330	COG1846	Transcriptional regulator
CLOBY_RS19335	COG1960	acyl-CoA dehydrogenase activity
CLOBY_RS19340	COG4670	ketone body catabolic process
CLOBY_RS19345	COG1024	Enoyl-CoA hydratase
CLOBY_RS19350	COG0495	leucyl-tRNA aminoacylation
CLOBY_RS19365	COG3279	Response regulator of the LytR AlgR family
CLOBY_RS19370	COG2205	protein histidine kinase activity
CLOBY_RS19400	COG2357	RelA SpoT domain protein
CLOBY_RS19410	COG0840	transmembrane signaling receptor activity
CLOBY_RS19425	COG1105	Belongs to the carbohydrate kinase PfkB family
CLOBY_RS19435	COG2723	6-phospho-beta-galactosidase activity
CLOBY_RS19440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOBY_RS19440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOBY_RS19455	COG0698	ribose 5-phosphate isomerase
CLOBY_RS19460	COG1349	DNA-binding transcription factor activity
CLOBY_RS19470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOBY_RS19480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLOBY_RS19490	COG2203	Gaf domain
CLOBY_RS19490	COG2199	diguanylate cyclase activity
CLOBY_RS19505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLOBY_RS19510	COG0673	inositol 2-dehydrogenase activity
CLOBY_RS19515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLOBY_RS19540	COG1442	glycosyl transferase family 8
CLOBY_RS19540	COG1216	Glycosyl transferase, family 2
CLOBY_RS19545	COG3475	LICD family
CLOBY_RS19550	COG1442	glycosyl transferase family 8
CLOBY_RS19550	COG1216	Glycosyl transferase, family 2
CLOBY_RS19555	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOBY_RS19575	COG1737	Transcriptional regulator
CLOBY_RS19590	COG2723	6-phospho-beta-galactosidase activity
CLOBY_RS19595	COG0561	phosphatase activity
CLOBY_RS19600	COG3706	GGDEF domain
CLOBY_RS19605	COG0697	spore germination
CLOBY_RS19615	COG0697	spore germination
CLOBY_RS19625	COG4750	Nucleotidyl transferase
CLOBY_RS19660	COG1737	Transcriptional regulator
CLOBY_RS19665	COG1737	Transcriptional regulator
CLOBY_RS19675	COG1486	melibiose metabolic process
CLOBY_RS19685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOBY_RS19685	COG1263	PTS System
CLOBY_RS19700	COG0463	Glycosyl transferase, family 2
CLOBY_RS19700	COG0457	Tetratricopeptide repeat
CLOBY_RS19710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLOBY_RS19725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLOBY_RS19745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLOBY_RS19775	COG1231	oxidoreductase activity
CLOBY_RS19780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOBY_RS19795	COG0584	glycerophosphoryl diester phosphodiesterase
CLOBY_RS19865	COG0463	Glycosyl transferase, family 2
CLOBY_RS19875	COG1216	Glycosyl transferase, family 2
CLOBY_RS19875	COG1442	glycosyl transferase family 8
CLOBY_RS19890	COG1682	transport, permease protein
CLOBY_RS19900	COG1216	Glycosyl transferase, family 2
CLOBY_RS19910	COG0438	transferase activity, transferring glycosyl groups
CLOBY_RS19940	COG0577	efflux transmembrane transporter activity
CLOBY_RS19940	COG1136	(ABC) transporter
CLOBY_RS19975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLOBY_RS19985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOBY_RS19995	COG1091	dTDP-4-dehydrorhamnose reductase activity
CLOBY_RS20005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLOBY_RS20040	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLOBY_RS20050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLOBY_RS20065	COG0489	protein tyrosine kinase activity
CLOBY_RS20070	COG3944	biosynthesis protein
CLOBY_RS20100	COG0840	transmembrane signaling receptor activity
CLOBY_RS20110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOBY_RS20115	COG0840	transmembrane signaling receptor activity
CLOBY_RS20120	COG0561	phosphatase activity
CLOBY_RS20125	COG1349	DNA-binding transcription factor activity
CLOBY_RS20130	COG0840	transmembrane signaling receptor activity
CLOBY_RS20135	COG3459	Glycosyltransferase 36 associated
CLOBY_RS20140	COG1362	aminopeptidase activity
CLOBY_RS20150	COG0840	transmembrane signaling receptor activity
CLOBY_RS20160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOBY_RS20165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLOBY_RS20170	COG3590	peptidase
CLOBY_RS20175	COG1126	abc transporter atp-binding protein
CLOBY_RS20180	COG0765	amino acid transport
CLOBY_RS20185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOBY_RS20195	COG3973	AAA domain
CLOBY_RS20200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOBY_RS20210	COG0681	Belongs to the peptidase S26 family
CLOBY_RS20220	COG0019	diaminopimelate decarboxylase activity
CLOBY_RS20240	COG0840	transmembrane signaling receptor activity
CLOBY_RS20245	COG2608	mercury ion transmembrane transporter activity
CLOBY_RS20255	COG1937	Protein conserved in bacteria
CLOBY_RS20260	COG1408	metallophosphoesterase
CLOBY_RS20265	COG1473	amidohydrolase
CLOBY_RS20270	COG1266	CAAX protease self-immunity
CLOBY_RS20290	COG0628	permease
CLOBY_RS20300	COG0469	pyruvate kinase activity
CLOBY_RS20325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLOBY_RS20330	COG1660	Displays ATPase and GTPase activities
CLOBY_RS20335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLOBY_RS20340	COG0322	excinuclease ABC activity
CLOBY_RS20345	COG0768	penicillin binding
CLOBY_RS20355	COG1716	ATPase activity
CLOBY_RS20365	COG0556	nucleotide-excision repair
CLOBY_RS20370	COG0833	amino acid
CLOBY_RS20380	COG0793	Belongs to the peptidase S41A family
CLOBY_RS20380	COG3409	Peptidoglycan-binding domain 1 protein
CLOBY_RS20385	COG2177	Part of the ABC transporter FtsEX involved in
CLOBY_RS20390	COG2884	Cell division ATP-binding protein ftsE
CLOBY_RS20395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOBY_RS20400	COG3958	Transketolase
CLOBY_RS20405	COG3959	Transketolase, thiamine diphosphate binding domain
CLOBY_RS20410	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOBY_RS20425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLOBY_RS20425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLOBY_RS20430	COG0736	holo-[acyl-carrier-protein] synthase activity
CLOBY_RS20440	COG0629	single-stranded DNA binding
CLOBY_RS20445	COG1295	ribonuclease BN
CLOBY_RS20450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOBY_RS20455	COG1696	Membrane protein involved in D-alanine export
CLOBY_RS20495	COG2002	toxin-antitoxin pair type II binding
CLOBY_RS20500	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLOBY_RS20505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLOBY_RS20520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLOBY_RS20525	COG3328	transposase activity
CLOBY_RS20535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLOBY_RS20565	COG1058	Belongs to the CinA family
CLOBY_RS20565	COG1546	Belongs to the CinA family
CLOBY_RS20570	COG1940	carbohydrate kinase activity
CLOBY_RS20585	COG2801	Transposase and inactivated derivatives
CLOBY_RS20590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOBY_RS20600	COG1368	sulfuric ester hydrolase activity
CLOBY_RS20665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLOBY_RS20710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOBY_RS20715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOBY_RS20725	COG0058	SHG alpha-glucan phosphorylase activity
CLOBY_RS20730	COG0297	glycogen (starch) synthase activity
CLOBY_RS20735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLOBY_RS20780	COG2190	(PTS) system
CLOBY_RS20780	COG1263	PTS System
CLOBY_RS20780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOBY_RS20785	COG3711	transcriptional antiterminator
CLOBY_RS20795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLOBY_RS20805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLOBY_RS20825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOBY_RS20830	COG4166	transmembrane transport
CLOBY_RS20835	COG4608	Belongs to the ABC transporter superfamily
CLOBY_RS20840	COG0444	Belongs to the ABC transporter superfamily
CLOBY_RS20845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOBY_RS20850	COG0601	transmembrane transport
CLOBY_RS20855	COG3590	peptidase
CLOBY_RS20885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOBY_RS20890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLOBY_RS20900	COG1733	regulation of RNA biosynthetic process
CLOBY_RS20920	COG1914	H( )-stimulated, divalent metal cation uptake system
CLOBY_RS20925	COG2239	Acts as a magnesium transporter
CLOBY_RS20930	COG0772	Belongs to the SEDS family
CLOBY_RS20950	COG0590	tRNA wobble adenosine to inosine editing
CLOBY_RS20955	COG1253	flavin adenine dinucleotide binding
CLOBY_RS20960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOBY_RS20965	COG1621	beta-fructofuranosidase activity
CLOBY_RS20970	COG1609	Transcriptional regulator
CLOBY_RS20980	COG3620	sequence-specific DNA binding
CLOBY_RS20985	COG1132	(ABC) transporter
CLOBY_RS20990	COG1132	(ABC) transporter
CLOBY_RS21000	COG2814	Major facilitator Superfamily
CLOBY_RS21025	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLOBY_RS21045	COG3290	protein histidine kinase activity
CLOBY_RS21050	COG4512	PFAM Accessory gene regulator B
CLOBY_RS21070	COG1131	(ABC) transporter
CLOBY_RS21140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLOBY_RS21150	COG0513	Belongs to the DEAD box helicase family
CLOBY_RS21160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLOBY_RS21160	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLOBY_RS21165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOBY_RS21165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOBY_RS21170	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOBY_RS21170	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOBY_RS21175	COG0617	tRNA 3'-terminal CCA addition
CLOBY_RS21180	COG0347	Belongs to the P(II) protein family
CLOBY_RS21185	COG0004	ammonium transporteR
CLOBY_RS21200	COG0659	secondary active sulfate transmembrane transporter activity
CLOBY_RS21205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOBY_RS21260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CLOBY_RS21265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CLOBY_RS21275	COG0037	tRNA processing
CLOBY_RS21300	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOBY_RS21330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLOBY_RS21335	COG2814	Major facilitator Superfamily
CLOBY_RS21340	COG0840	transmembrane signaling receptor activity
CLOBY_RS21345	COG0653	protein targeting
CLOBY_RS21350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLOBY_RS21375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOBY_RS21380	COG1404	Belongs to the peptidase S8 family
CLOBY_RS21415	COG2081	HI0933 family
CLOBY_RS21435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLOBY_RS21445	COG0305	Participates in initiation and elongation during chromosome replication
CLOBY_RS21450	COG1067	ATP-dependent peptidase activity
CLOBY_RS21450	COG0470	DNA polymerase III
CLOBY_RS21455	COG0359	binds to the 23S rRNA
CLOBY_RS21460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLOBY_RS21470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLOBY_RS21475	COG0629	single-stranded DNA binding
CLOBY_RS21480	COG0360	Binds together with S18 to 16S ribosomal RNA
CLOBY_RS21490	COG0668	transmembrane transport
CLOBY_RS21525	COG1192	Involved in chromosome partitioning
CLOBY_RS21535	COG0357	Ribosomal RNA small subunit methyltransferase G
CLOBY_RS21540	COG0445	tRNA wobble uridine modification
CLOBY_RS21545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLOBY_RS21550	COG1847	R3H domain protein
CLOBY_RS21560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLOBY_RS21565	COG0594	ribonuclease P activity
CLOBY_RS21570	COG0230	Belongs to the bacterial ribosomal protein bL34 family