locus-tag	class	description
CLOSA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLOSA_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOSA_RS00025	COG0187	DNA topoisomerase II activity
CLOSA_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOSA_RS00045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSA_RS00050	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLOSA_RS00055	COG2723	6-phospho-beta-galactosidase activity
CLOSA_RS00080	COG0204	Acyl-transferase
CLOSA_RS00145	COG1982	Orn Lys Arg decarboxylase major
CLOSA_RS00150	COG0194	GDP metabolic process
CLOSA_RS00155	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS00160	COG1129	ABC transporter
CLOSA_RS00175	COG2972	Histidine kinase
CLOSA_RS00180	COG2207	Transcriptional regulator
CLOSA_RS00180	COG4753	response regulator
CLOSA_RS00185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOSA_RS00190	COG1774	PSP1 C-terminal conserved region
CLOSA_RS00195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLOSA_RS00200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLOSA_RS00205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOSA_RS00210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOSA_RS00215	COG2070	2-Nitropropane dioxygenase
CLOSA_RS00220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLOSA_RS00225	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS00230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLOSA_RS00235	COG0511	ligase activity, forming carbon-carbon bonds
CLOSA_RS00240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLOSA_RS00245	COG0439	Biotin carboxylase
CLOSA_RS00265	COG2715	membrane protein required for spore maturation
CLOSA_RS00275	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CLOSA_RS00285	COG2186	Transcriptional regulator
CLOSA_RS00300	COG3833	ABC-type maltose transport systems, permease component
CLOSA_RS00305	COG3959	Transketolase, thiamine diphosphate binding domain
CLOSA_RS00310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLOSA_RS00335	COG0166	Belongs to the GPI family
CLOSA_RS00350	COG1175	transmembrane transport
CLOSA_RS00355	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS00360	COG3250	beta-galactosidase activity
CLOSA_RS00375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLOSA_RS00380	COG1609	Transcriptional regulator
CLOSA_RS00410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLOSA_RS00420	COG1940	carbohydrate kinase activity
CLOSA_RS00430	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CLOSA_RS00435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOSA_RS00445	COG1129	ABC transporter
CLOSA_RS00465	COG0457	Tetratricopeptide repeat
CLOSA_RS00485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLOSA_RS00490	COG0840	transmembrane signaling receptor activity
CLOSA_RS00495	COG0840	transmembrane signaling receptor activity
CLOSA_RS00500	COG2190	(PTS) system
CLOSA_RS00500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS00500	COG1263	PTS System
CLOSA_RS00505	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CLOSA_RS00510	COG1737	Transcriptional regulator
CLOSA_RS00515	COG1414	Transcriptional regulator
CLOSA_RS00525	COG4209	transmembrane transport
CLOSA_RS00530	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS00550	COG3842	ATPase activity
CLOSA_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS00590	COG4708	membrane
CLOSA_RS00605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLOSA_RS00615	COG1484	DNA-dependent DNA replication
CLOSA_RS00620	COG1404	Belongs to the peptidase S8 family
CLOSA_RS00625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLOSA_RS00630	COG1114	Component of the transport system for branched-chain amino acids
CLOSA_RS00635	COG4717	serine-type aminopeptidase activity
CLOSA_RS00645	COG0017	Asparaginyl-tRNA synthetase
CLOSA_RS00650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOSA_RS00655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOSA_RS00660	COG2088	sporulation resulting in formation of a cellular spore
CLOSA_RS00665	COG1748	Saccharopine dehydrogenase
CLOSA_RS00695	COG0640	Transcriptional regulator
CLOSA_RS00765	COG1121	(ABC) transporter
CLOSA_RS00770	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLOSA_RS00785	COG0705	Rhomboid family
CLOSA_RS00785	COG0457	Tetratricopeptide repeat
CLOSA_RS00790	COG0537	adenosine 5'-monophosphoramidase activity
CLOSA_RS00800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOSA_RS00810	COG1393	Belongs to the ArsC family
CLOSA_RS00820	COG1846	Transcriptional regulator
CLOSA_RS00850	COG0084	hydrolase, TatD family'
CLOSA_RS00855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLOSA_RS00870	COG4716	Myosin-crossreactive antigen
CLOSA_RS00875	COG4166	transmembrane transport
CLOSA_RS00880	COG4475	Protein of unknown function (DUF436)
CLOSA_RS00890	COG2703	oxygen carrier activity
CLOSA_RS00900	COG0363	glucosamine-6-phosphate deaminase activity
CLOSA_RS00910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLOSA_RS00915	COG0590	tRNA wobble adenosine to inosine editing
CLOSA_RS00920	COG0205	6-phosphofructokinase activity
CLOSA_RS00925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOSA_RS00930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLOSA_RS00935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLOSA_RS00945	COG0561	phosphatase activity
CLOSA_RS01090	COG2188	Transcriptional regulator
CLOSA_RS01095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS01105	COG3715	PTS system
CLOSA_RS01110	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS01115	COG4821	SIS domain
CLOSA_RS01150	COG1695	Transcriptional regulator
CLOSA_RS01155	COG0582	viral genome integration into host DNA
CLOSA_RS01160	COG0840	transmembrane signaling receptor activity
CLOSA_RS01165	COG2199	diguanylate cyclase activity
CLOSA_RS01165	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOSA_RS01185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLOSA_RS01195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOSA_RS01200	COG0840	transmembrane signaling receptor activity
CLOSA_RS01230	COG0667	Aldo Keto reductase
CLOSA_RS01245	COG0629	single-stranded DNA binding
CLOSA_RS01250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLOSA_RS01255	COG0840	transmembrane signaling receptor activity
CLOSA_RS01260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOSA_RS01265	COG4978	Transcriptional regulator
CLOSA_RS01265	COG0789	Transcriptional regulator
CLOSA_RS01285	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS01290	COG3850	Histidine kinase
CLOSA_RS01290	COG5002	protein histidine kinase activity
CLOSA_RS01305	COG1191	sigma factor activity
CLOSA_RS01325	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS01335	COG1802	Transcriptional regulator
CLOSA_RS01340	COG1115	amino acid carrier protein
CLOSA_RS01345	COG3033	Beta-eliminating lyase
CLOSA_RS01350	COG2207	Transcriptional regulator
CLOSA_RS01350	COG4753	response regulator
CLOSA_RS01355	COG2972	Histidine kinase
CLOSA_RS01360	COG1879	ABC-type sugar transport system periplasmic component
CLOSA_RS01365	COG1129	ABC transporter
CLOSA_RS01370	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS01375	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS01390	COG1609	Transcriptional regulator
CLOSA_RS01420	COG1966	Carbon starvation protein
CLOSA_RS01460	COG2226	methyltransferase
CLOSA_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS01475	COG0583	DNA-binding transcription factor activity
CLOSA_RS01535	COG0791	NLP P60 protein
CLOSA_RS01535	COG1388	LysM domain
CLOSA_RS01555	COG2088	sporulation resulting in formation of a cellular spore
CLOSA_RS01590	COG1475	DNA binding
CLOSA_RS01600	COG0326	Molecular chaperone. Has ATPase activity
CLOSA_RS01615	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLOSA_RS01620	COG0359	binds to the 23S rRNA
CLOSA_RS01625	COG0305	Participates in initiation and elongation during chromosome replication
CLOSA_RS01635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOSA_RS01645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLOSA_RS01675	COG1486	melibiose metabolic process
CLOSA_RS01680	COG4977	sequence-specific DNA binding
CLOSA_RS01690	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLOSA_RS01695	COG1760	l-serine dehydratase
CLOSA_RS01700	COG1760	l-serine dehydratase
CLOSA_RS01705	COG1846	Transcriptional regulator
CLOSA_RS01710	COG0534	Mate efflux family protein
CLOSA_RS01730	COG0515	serine threonine protein kinase
CLOSA_RS01730	COG3266	domain, Protein
CLOSA_RS01755	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOSA_RS01775	COG1653	transport
CLOSA_RS01785	COG1940	carbohydrate kinase activity
CLOSA_RS01790	COG0673	inositol 2-dehydrogenase activity
CLOSA_RS01795	COG0840	transmembrane signaling receptor activity
CLOSA_RS01800	COG2502	aspartate--ammonia ligase
CLOSA_RS01805	COG0009	L-threonylcarbamoyladenylate synthase
CLOSA_RS01820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLOSA_RS01825	COG2176	DNA-directed DNA polymerase activity
CLOSA_RS01835	COG2720	vancomycin resistance protein
CLOSA_RS01845	COG1522	sequence-specific DNA binding
CLOSA_RS01850	COG0436	Aminotransferase
CLOSA_RS01860	COG5002	protein histidine kinase activity
CLOSA_RS01860	COG3850	Histidine kinase
CLOSA_RS01865	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS01870	COG1193	negative regulation of DNA recombination
CLOSA_RS01875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLOSA_RS01880	COG3481	metal-dependent phosphohydrolase, HD sub domain
CLOSA_RS01890	COG5002	protein histidine kinase activity
CLOSA_RS01895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLOSA_RS01900	COG0704	Plays a role in the regulation of phosphate uptake
CLOSA_RS01905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOSA_RS01910	COG0581	inorganic phosphate transmembrane transporter activity
CLOSA_RS01915	COG0573	inorganic phosphate transmembrane transporter activity
CLOSA_RS01920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLOSA_RS01925	COG0653	protein targeting
CLOSA_RS01945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLOSA_RS01960	COG1609	Transcriptional regulator
CLOSA_RS01965	COG1982	Orn Lys Arg decarboxylase major
CLOSA_RS02000	COG1045	serine acetyltransferase
CLOSA_RS02025	COG0564	pseudouridine synthase activity
CLOSA_RS02035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOSA_RS02040	COG0617	tRNA 3'-terminal CCA addition
CLOSA_RS02050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOSA_RS02060	COG0488	(ABC) transporter
CLOSA_RS02065	COG1077	Cell shape determining protein MreB Mrl
CLOSA_RS02070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOSA_RS02075	COG1040	competence protein
CLOSA_RS02085	COG0789	Transcriptional regulator
CLOSA_RS02105	COG2169	Transcriptional regulator
CLOSA_RS02105	COG1917	Cupin 2, conserved barrel domain protein
CLOSA_RS02110	COG1653	transport
CLOSA_RS02120	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS02125	COG4948	Mandelate Racemase Muconate Lactonizing
CLOSA_RS02130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLOSA_RS02140	COG0250	Participates in transcription elongation, termination and antitermination
CLOSA_RS02145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLOSA_RS02150	COG0081	regulation of translation
CLOSA_RS02160	COG0222	ribosome binding
CLOSA_RS02165	COG1278	Cold shock
CLOSA_RS02170	COG0726	polysaccharide deacetylase
CLOSA_RS02180	COG4886	Leucine-rich repeat (LRR) protein
CLOSA_RS02220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLOSA_RS02225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLOSA_RS02230	COG0254	rRNA binding
CLOSA_RS02240	COG2890	protein-(glutamine-N5) methyltransferase activity
CLOSA_RS02245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLOSA_RS02250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS02250	COG3711	transcriptional antiterminator
CLOSA_RS02260	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLOSA_RS02270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSA_RS02275	COG1486	melibiose metabolic process
CLOSA_RS02285	COG3681	Belongs to the UPF0597 family
CLOSA_RS02310	COG0252	asparaginase activity
CLOSA_RS02320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOSA_RS02335	COG0077	Prephenate dehydratase
CLOSA_RS02335	COG1605	Chorismate mutase
CLOSA_RS02350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLOSA_RS02370	COG1131	(ABC) transporter
CLOSA_RS02380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CLOSA_RS02410	COG0534	Mate efflux family protein
CLOSA_RS02425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOSA_RS02435	COG1363	Peptidase, m42
CLOSA_RS02445	COG1486	melibiose metabolic process
CLOSA_RS02455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSA_RS02460	COG2723	6-phospho-beta-galactosidase activity
CLOSA_RS02470	COG2188	Transcriptional regulator
CLOSA_RS02475	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLOSA_RS02480	COG1924	4 iron, 4 sulfur cluster binding
CLOSA_RS02490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOSA_RS02495	COG1126	abc transporter atp-binding protein
CLOSA_RS02505	COG0561	phosphatase activity
CLOSA_RS02510	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOSA_RS02525	COG3845	ABC transporter
CLOSA_RS02530	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS02535	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS02540	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOSA_RS02545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOSA_RS02550	COG1957	nucleoside hydrolase
CLOSA_RS02560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLOSA_RS02575	COG3475	LICD family
CLOSA_RS02595	COG1115	amino acid carrier protein
CLOSA_RS02605	COG2169	Transcriptional regulator
CLOSA_RS02605	COG1917	Cupin 2, conserved barrel domain protein
CLOSA_RS02610	COG2207	Transcriptional regulator
CLOSA_RS02615	COG0740	serine-type endopeptidase activity
CLOSA_RS02625	COG0242	peptide deformylase activity
CLOSA_RS02635	COG1331	Highly conserved protein containing a thioredoxin domain
CLOSA_RS02640	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CLOSA_RS02650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLOSA_RS02655	COG0519	Catalyzes the synthesis of GMP from XMP
CLOSA_RS02670	COG2357	RelA SpoT domain protein
CLOSA_RS02675	COG0004	ammonium transporteR
CLOSA_RS02680	COG0347	Belongs to the P(II) protein family
CLOSA_RS02685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLOSA_RS02690	COG1802	Transcriptional regulator
CLOSA_RS02700	COG1309	transcriptional regulator
CLOSA_RS02710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLOSA_RS02730	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOSA_RS02735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLOSA_RS02750	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS02755	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS02780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLOSA_RS02785	COG0438	transferase activity, transferring glycosyl groups
CLOSA_RS02800	COG0438	transferase activity, transferring glycosyl groups
CLOSA_RS02810	COG0438	transferase activity, transferring glycosyl groups
CLOSA_RS02835	COG0463	Glycosyl transferase, family 2
CLOSA_RS02870	COG4372	Transposase
CLOSA_RS02935	COG0028	Belongs to the TPP enzyme family
CLOSA_RS02955	COG0463	Glycosyl transferase, family 2
CLOSA_RS02960	COG0438	transferase activity, transferring glycosyl groups
CLOSA_RS02960	COG1216	Glycosyl transferase, family 2
CLOSA_RS02980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLOSA_RS02985	COG1609	Transcriptional regulator
CLOSA_RS02995	COG1175	transmembrane transport
CLOSA_RS03000	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS03060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLOSA_RS03065	COG1253	flavin adenine dinucleotide binding
CLOSA_RS03085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLOSA_RS03085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLOSA_RS03090	COG0343	queuine tRNA-ribosyltransferase activity
CLOSA_RS03105	COG1175	transmembrane transport
CLOSA_RS03110	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS03115	COG0191	fructose-bisphosphate aldolase activity
CLOSA_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS03140	COG0492	ferredoxin-NADP+ reductase activity
CLOSA_RS03145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CLOSA_RS03150	COG0653	protein targeting
CLOSA_RS03155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLOSA_RS03160	COG4492	Belongs to the UPF0735 family
CLOSA_RS03165	COG0460	homoserine dehydrogenase
CLOSA_RS03190	COG2183	response to ionizing radiation
CLOSA_RS03200	COG0802	atpase or kinase
CLOSA_RS03205	COG1214	PFAM Peptidase M22, glycoprotease
CLOSA_RS03210	COG0456	acetyltransferase
CLOSA_RS03220	COG1234	tRNA 3'-trailer cleavage
CLOSA_RS03230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLOSA_RS03330	COG4948	Mandelate Racemase Muconate Lactonizing
CLOSA_RS03335	COG4166	transmembrane transport
CLOSA_RS03340	COG0601	transmembrane transport
CLOSA_RS03345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOSA_RS03350	COG0444	Belongs to the ABC transporter superfamily
CLOSA_RS03360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CLOSA_RS03375	COG1840	ABC-type Fe3 transport system, periplasmic component
CLOSA_RS03385	COG3842	ATPase activity
CLOSA_RS03405	COG1011	Hydrolase
CLOSA_RS03430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLOSA_RS03430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLOSA_RS03435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLOSA_RS03455	COG2080	2 iron, 2 sulfur cluster binding
CLOSA_RS03455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLOSA_RS03460	COG0577	efflux transmembrane transporter activity
CLOSA_RS03460	COG1136	(ABC) transporter
CLOSA_RS03510	COG0469	pyruvate kinase activity
CLOSA_RS03525	COG1404	Belongs to the peptidase S8 family
CLOSA_RS03535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLOSA_RS03545	COG1418	mRNA catabolic process
CLOSA_RS03550	COG1686	Belongs to the peptidase S11 family
CLOSA_RS03585	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CLOSA_RS03600	COG0791	NLP P60 protein
CLOSA_RS03600	COG0741	lytic transglycosylase activity
CLOSA_RS03615	COG0622	Phosphoesterase
CLOSA_RS03620	COG0116	Belongs to the methyltransferase superfamily
CLOSA_RS03630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLOSA_RS03755	COG1192	Involved in chromosome partitioning
CLOSA_RS03765	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS03875	COG0740	serine-type endopeptidase activity
CLOSA_RS03980	COG0582	viral genome integration into host DNA
CLOSA_RS04030	COG0330	HflC and HflK could
CLOSA_RS04075	COG3693	PFAM glycoside hydrolase, family 10
CLOSA_RS04100	COG2996	Protein conserved in bacteria
CLOSA_RS04110	COG3842	ATPase activity
CLOSA_RS04115	COG3835	regulator
CLOSA_RS04120	COG2884	Cell division ATP-binding protein ftsE
CLOSA_RS04125	COG2177	Part of the ABC transporter FtsEX involved in
CLOSA_RS04135	COG0793	Belongs to the peptidase S41A family
CLOSA_RS04175	COG1388	LysM domain
CLOSA_RS04175	COG3858	chitin binding
CLOSA_RS04210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLOSA_RS04215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLOSA_RS04220	COG0583	DNA-binding transcription factor activity
CLOSA_RS04240	COG2246	polysaccharide biosynthetic process
CLOSA_RS04245	COG4485	Bacterial membrane protein, YfhO
CLOSA_RS04250	COG0165	Argininosuccinate lyase
CLOSA_RS04265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLOSA_RS04265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLOSA_RS04275	COG1760	l-serine dehydratase
CLOSA_RS04280	COG1760	l-serine dehydratase
CLOSA_RS04285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOSA_RS04290	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLOSA_RS04305	COG0149	triose-phosphate isomerase activity
CLOSA_RS04310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLOSA_RS04320	COG1132	(ABC) transporter
CLOSA_RS04325	COG1307	EDD domain protein, DegV family
CLOSA_RS04330	COG5002	protein histidine kinase activity
CLOSA_RS04340	COG2333	competence protein COMEC
CLOSA_RS04340	COG0658	competence protein
CLOSA_RS04345	COG1466	dna polymerase III delta subunit
CLOSA_RS04465	COG4824	toxin secretion phage lysis holin
CLOSA_RS04490	COG1175	transmembrane transport
CLOSA_RS04495	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS04500	COG1554	hydrolase, family 65, central catalytic
CLOSA_RS04510	COG0366	Alpha amylase catalytic
CLOSA_RS04515	COG0268	Binds directly to 16S ribosomal RNA
CLOSA_RS04520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CLOSA_RS04530	COG0481	GTPase activity
CLOSA_RS04535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOSA_RS04550	COG1420	regulation of RNA biosynthetic process
CLOSA_RS04555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLOSA_RS04560	COG0443	Heat shock 70 kDa protein
CLOSA_RS04565	COG0484	heat shock protein binding
CLOSA_RS04580	COG2264	protein methyltransferase activity
CLOSA_RS04585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLOSA_RS04590	COG1104	cysteine desulfurase activity
CLOSA_RS04595	COG0301	tRNA thio-modification
CLOSA_RS04605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOSA_RS04610	COG4472	Bacterial protein of unknown function (DUF965)
CLOSA_RS04625	COG0735	belongs to the Fur family
CLOSA_RS04630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLOSA_RS04640	COG4122	O-methyltransferase activity
CLOSA_RS04645	COG0826	peptidase U32
CLOSA_RS04670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLOSA_RS04675	COG1381	Involved in DNA repair and RecF pathway recombination
CLOSA_RS04690	COG0423	glycine-tRNA ligase activity
CLOSA_RS04695	COG0662	Cupin 2, conserved barrel domain protein
CLOSA_RS04700	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS04705	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS04710	COG3845	ABC transporter
CLOSA_RS04715	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOSA_RS04725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOSA_RS04725	COG0574	Belongs to the PEP-utilizing enzyme family
CLOSA_RS04745	COG0583	DNA-binding transcription factor activity
CLOSA_RS04750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLOSA_RS04760	COG2972	Histidine kinase
CLOSA_RS04765	COG2197	response regulator
CLOSA_RS04775	COG1653	transport
CLOSA_RS04785	COG1175	transmembrane transport
CLOSA_RS04790	COG3833	ABC-type maltose transport systems, permease component
CLOSA_RS04815	COG1773	rubredoxin
CLOSA_RS04820	COG1528	Iron-storage protein
CLOSA_RS04825	COG0426	domain, Protein
CLOSA_RS04830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLOSA_RS04830	COG3608	succinylglutamate desuccinylase aspartoacylase
CLOSA_RS04840	COG1683	Conserved Protein
CLOSA_RS04850	COG0527	aspartate kinase activity
CLOSA_RS04855	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSA_RS04860	COG1823	symporter activity
CLOSA_RS04865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLOSA_RS04875	COG0366	Alpha amylase catalytic
CLOSA_RS04880	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS04885	COG1175	transmembrane transport
CLOSA_RS04895	COG2207	Transcriptional regulator
CLOSA_RS04895	COG4753	response regulator
CLOSA_RS04900	COG3275	phosphorelay sensor kinase activity
CLOSA_RS04910	COG0366	Alpha amylase catalytic
CLOSA_RS04915	COG0110	maltose O-acetyltransferase activity
CLOSA_RS04920	COG1396	sequence-specific DNA binding
CLOSA_RS04925	COG0667	Aldo Keto reductase
CLOSA_RS04940	COG2081	HI0933 family
CLOSA_RS04945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLOSA_RS04950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOSA_RS04955	COG0539	negative regulation of cytoplasmic translation
CLOSA_RS04955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOSA_RS04960	COG3590	peptidase
CLOSA_RS04975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOSA_RS04975	COG1918	ferrous iron import across plasma membrane
CLOSA_RS05000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOSA_RS05010	COG1116	anion transmembrane transporter activity
CLOSA_RS05020	COG3804	dihydrodipicolinate reductase
CLOSA_RS05040	COG1486	melibiose metabolic process
CLOSA_RS05045	COG1263	PTS System
CLOSA_RS05045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS05050	COG1737	Transcriptional regulator
CLOSA_RS05055	COG1737	Transcriptional regulator
CLOSA_RS05075	COG1122	ATPase activity
CLOSA_RS05100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOSA_RS05135	COG1175	transmembrane transport
CLOSA_RS05140	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS05155	COG1388	LysM domain
CLOSA_RS05155	COG3858	chitin binding
CLOSA_RS05160	COG1070	Carbohydrate kinase
CLOSA_RS05170	COG4806	L-rhamnose isomerase
CLOSA_RS05175	COG0235	Class ii aldolase
CLOSA_RS05185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLOSA_RS05190	COG0459	protein refolding
CLOSA_RS05200	COG0516	GMP reductase activity
CLOSA_RS05200	COG0517	IMP dehydrogenase activity
CLOSA_RS05210	COG0697	spore germination
CLOSA_RS05230	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLOSA_RS05235	COG1074	ATP-dependent DNA helicase activity
CLOSA_RS05240	COG0709	Synthesizes selenophosphate from selenide and ATP
CLOSA_RS05245	COG1104	cysteine desulfurase activity
CLOSA_RS05250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLOSA_RS05250	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLOSA_RS05260	COG0402	S-adenosylhomocysteine deaminase activity
CLOSA_RS05265	COG2252	PERMEase
CLOSA_RS05270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLOSA_RS05275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLOSA_RS05280	COG2080	2 iron, 2 sulfur cluster binding
CLOSA_RS05285	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CLOSA_RS05290	COG2207	Transcriptional regulator
CLOSA_RS05290	COG1917	Cupin 2, conserved barrel domain protein
CLOSA_RS05295	COG0058	SHG alpha-glucan phosphorylase activity
CLOSA_RS05305	COG0549	Belongs to the carbamate kinase family
CLOSA_RS05310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLOSA_RS05315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLOSA_RS05330	COG0402	S-adenosylhomocysteine deaminase activity
CLOSA_RS05335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOSA_RS05335	COG0493	'glutamate synthase
CLOSA_RS05345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOSA_RS05365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLOSA_RS05375	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLOSA_RS05380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLOSA_RS05380	COG3608	succinylglutamate desuccinylase aspartoacylase
CLOSA_RS05385	COG0746	molybdenum cofactor guanylyltransferase activity
CLOSA_RS05420	COG2207	Transcriptional regulator
CLOSA_RS05445	COG1379	DNA repair
CLOSA_RS05450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLOSA_RS05485	COG1051	belongs to the nudix hydrolase family
CLOSA_RS05495	COG1131	(ABC) transporter
CLOSA_RS05505	COG1193	negative regulation of DNA recombination
CLOSA_RS05520	COG3870	Protein conserved in bacteria
CLOSA_RS05525	COG0295	cytidine deaminase activity
CLOSA_RS05545	COG0024	Methionine aminopeptidase
CLOSA_RS05550	COG0519	Catalyzes the synthesis of GMP from XMP
CLOSA_RS05565	COG0322	excinuclease ABC activity
CLOSA_RS05570	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLOSA_RS05585	COG1481	regulation of sporulation
CLOSA_RS05610	COG0246	Mannitol dehydrogenase
CLOSA_RS05615	COG2721	sulfolactate sulfo-lyase activity
CLOSA_RS05620	COG1609	Transcriptional regulator
CLOSA_RS05635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLOSA_RS05640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLOSA_RS05655	COG5377	YqaJ viral recombinase family
CLOSA_RS05660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOSA_RS05705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLOSA_RS05745	COG3620	sequence-specific DNA binding
CLOSA_RS05750	COG4474	Belongs to the UPF0398 family
CLOSA_RS05760	COG0488	(ABC) transporter
CLOSA_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS05775	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CLOSA_RS05775	COG2508	Transcriptional regulator
CLOSA_RS05780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLOSA_RS05800	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLOSA_RS05805	COG0105	UTP biosynthetic process
CLOSA_RS05820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLOSA_RS05825	COG3404	Formiminotransferase-cyclodeaminase
CLOSA_RS05830	COG2116	formate transmembrane transporter activity
CLOSA_RS05835	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLOSA_RS05840	COG0285	dihydrofolate synthase activity
CLOSA_RS05860	COG1846	Transcriptional regulator
CLOSA_RS05880	COG2801	Transposase and inactivated derivatives
CLOSA_RS05895	COG3708	Transcriptional regulator
CLOSA_RS05895	COG2207	Transcriptional regulator
CLOSA_RS05940	COG2211	Major facilitator Superfamily
CLOSA_RS05945	COG3408	Glycogen debranching enzyme
CLOSA_RS05965	COG0095	Lipoate-protein ligase
CLOSA_RS05970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOSA_RS05980	COG2897	thiosulfate sulfurtransferase activity
CLOSA_RS05990	COG0398	Pfam SNARE associated Golgi protein
CLOSA_RS06000	COG0398	Pfam SNARE associated Golgi protein
CLOSA_RS06010	COG0463	Glycosyl transferase, family 2
CLOSA_RS06020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLOSA_RS06025	COG4134	Bacterial extracellular solute-binding protein
CLOSA_RS06040	COG3842	ATPase activity
CLOSA_RS06065	COG1554	hydrolase, family 65, central catalytic
CLOSA_RS06070	COG1609	Transcriptional regulator
CLOSA_RS06080	COG1175	transmembrane transport
CLOSA_RS06085	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS06090	COG1501	Belongs to the glycosyl hydrolase 31 family
CLOSA_RS06115	COG1876	peptidase activity
CLOSA_RS06130	COG1129	ABC transporter
CLOSA_RS06135	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS06140	COG0667	Aldo Keto reductase
CLOSA_RS06165	COG1263	PTS System
CLOSA_RS06165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS06165	COG2190	(PTS) system
CLOSA_RS06170	COG2723	6-phospho-beta-galactosidase activity
CLOSA_RS06175	COG3715	PTS system
CLOSA_RS06180	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS06190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS06195	COG1737	Transcriptional regulator
CLOSA_RS06200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CLOSA_RS06205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLOSA_RS06210	COG0617	tRNA 3'-terminal CCA addition
CLOSA_RS06225	COG2186	Transcriptional regulator
CLOSA_RS06230	COG0626	cystathionine gamma-synthase activity
CLOSA_RS06255	COG0534	Mate efflux family protein
CLOSA_RS06260	COG3257	ureidoglycine aminohydrolase activity
CLOSA_RS06270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOSA_RS06270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOSA_RS06270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS06275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOSA_RS06275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CLOSA_RS06275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOSA_RS06280	COG0191	fructose-bisphosphate aldolase activity
CLOSA_RS06290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS06295	COG0667	Aldo Keto reductase
CLOSA_RS06320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLOSA_RS06330	COG1136	(ABC) transporter
CLOSA_RS06335	COG1136	(ABC) transporter
CLOSA_RS06335	COG0577	efflux transmembrane transporter activity
CLOSA_RS06340	COG0577	efflux transmembrane transporter activity
CLOSA_RS06355	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLOSA_RS06365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS06370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOSA_RS06385	COG1737	Transcriptional regulator
CLOSA_RS06390	COG1486	melibiose metabolic process
CLOSA_RS06395	COG1263	PTS System
CLOSA_RS06395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS06405	COG2169	Transcriptional regulator
CLOSA_RS06410	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOSA_RS06415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLOSA_RS06425	COG0436	Aminotransferase
CLOSA_RS06430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOSA_RS06435	COG0628	permease
CLOSA_RS06460	COG1131	(ABC) transporter
CLOSA_RS06465	COG0640	Transcriptional regulator
CLOSA_RS06475	COG2217	Heavy metal translocating P-type atpase
CLOSA_RS06490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLOSA_RS06495	COG0436	Aminotransferase
CLOSA_RS06505	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOSA_RS06515	COG3409	Peptidoglycan-binding domain 1 protein
CLOSA_RS06515	COG5632	N-Acetylmuramoyl-L-alanine amidase
CLOSA_RS06535	COG3546	catalase activity
CLOSA_RS06580	COG1653	transport
CLOSA_RS06590	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS06595	COG1802	Transcriptional regulator
CLOSA_RS06600	COG1597	lipid kinase activity
CLOSA_RS06605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLOSA_RS06610	COG0215	cysteine-tRNA ligase activity
CLOSA_RS06615	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CLOSA_RS06620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOSA_RS06670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLOSA_RS06675	COG2239	Acts as a magnesium transporter
CLOSA_RS06680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLOSA_RS06685	COG0210	DNA helicase
CLOSA_RS06695	COG3906	Belongs to the UPF0473 family
CLOSA_RS06715	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CLOSA_RS06715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOSA_RS06720	COG0564	pseudouridine synthase activity
CLOSA_RS06730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOSA_RS06735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLOSA_RS06740	COG1686	Belongs to the peptidase S11 family
CLOSA_RS06745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOSA_RS06755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLOSA_RS06765	COG4770	biotin carboxylase activity
CLOSA_RS06770	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CLOSA_RS06800	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CLOSA_RS06805	COG0542	response to heat
CLOSA_RS06815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLOSA_RS06820	COG1309	transcriptional regulator
CLOSA_RS06825	COG3848	Pyruvate phosphate dikinase
CLOSA_RS06825	COG0574	Belongs to the PEP-utilizing enzyme family
CLOSA_RS06860	COG0583	DNA-binding transcription factor activity
CLOSA_RS06865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOSA_RS06870	COG0406	alpha-ribazole phosphatase activity
CLOSA_RS06880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLOSA_RS06895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOSA_RS06900	COG0367	asparagine synthase
CLOSA_RS06905	COG3069	C4-dicarboxylate transmembrane transporter activity
CLOSA_RS06915	COG0110	maltose O-acetyltransferase activity
CLOSA_RS06920	COG1070	Carbohydrate kinase
CLOSA_RS06965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOSA_RS07075	COG5484	DNA packaging
CLOSA_RS07080	COG1783	phage Terminase large subunit
CLOSA_RS07150	COG1652	LysM domain
CLOSA_RS07170	COG3299	homolog of phage Mu protein gp47
CLOSA_RS07210	COG1793	dna ligase
CLOSA_RS07245	COG3858	chitin binding
CLOSA_RS07245	COG1388	LysM domain
CLOSA_RS07250	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOSA_RS07285	COG3250	beta-galactosidase activity
CLOSA_RS07305	COG0789	Transcriptional regulator
CLOSA_RS07310	COG1309	transcriptional regulator
CLOSA_RS07320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLOSA_RS07330	COG0789	Transcriptional regulator
CLOSA_RS07330	COG4978	Transcriptional regulator
CLOSA_RS07335	COG2186	Transcriptional regulator
CLOSA_RS07340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CLOSA_RS07350	COG0375	protein maturation
CLOSA_RS07370	COG0438	transferase activity, transferring glycosyl groups
CLOSA_RS07375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLOSA_RS07395	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS07405	COG1070	Carbohydrate kinase
CLOSA_RS07410	COG1757	Na H antiporter
CLOSA_RS07420	COG0434	BtpA family
CLOSA_RS07425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSA_RS07450	COG0531	amino acid
CLOSA_RS07455	COG2188	Transcriptional regulator
CLOSA_RS07465	COG2188	Transcriptional regulator
CLOSA_RS07475	COG1082	Xylose isomerase domain protein TIM barrel
CLOSA_RS07480	COG2188	Transcriptional regulator
CLOSA_RS07490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLOSA_RS07500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS07510	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS07515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLOSA_RS07520	COG1940	carbohydrate kinase activity
CLOSA_RS07535	COG1309	transcriptional regulator
CLOSA_RS07560	COG4917	ethanolamine utilization protein
CLOSA_RS07565	COG2096	Adenosyltransferase
CLOSA_RS07585	COG4303	Ethanolamine ammonia lyase large subunit
CLOSA_RS07600	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOSA_RS07605	COG1012	belongs to the aldehyde dehydrogenase family
CLOSA_RS07605	COG1454	alcohol dehydrogenase
CLOSA_RS07620	COG4869	propanediol catabolic process
CLOSA_RS07630	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOSA_RS07655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOSA_RS07655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS07655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS07660	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLOSA_RS07665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSA_RS07670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSA_RS07680	COG1446	asparaginase
CLOSA_RS07690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOSA_RS07700	COG0583	DNA-binding transcription factor activity
CLOSA_RS07705	COG2391	methyltransferase activity
CLOSA_RS07710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLOSA_RS07710	COG0425	Belongs to the sulfur carrier protein TusA family
CLOSA_RS07725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLOSA_RS07730	COG0509	glycine decarboxylation via glycine cleavage system
CLOSA_RS07735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOSA_RS07740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOSA_RS07745	COG0095	Lipoate-protein ligase
CLOSA_RS07760	COG0534	Mate efflux family protein
CLOSA_RS07780	COG0531	amino acid
CLOSA_RS07790	COG1653	transport
CLOSA_RS07795	COG1175	transmembrane transport
CLOSA_RS07805	COG3250	beta-galactosidase activity
CLOSA_RS07840	COG1278	Cold shock
CLOSA_RS07845	COG0662	Cupin 2, conserved barrel domain protein
CLOSA_RS07860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOSA_RS07865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLOSA_RS07870	COG0561	phosphatase activity
CLOSA_RS07875	COG4496	protein, YerC YecD
CLOSA_RS07885	COG0251	oxidation-reduction process
CLOSA_RS07915	COG2172	sigma factor antagonist activity
CLOSA_RS07955	COG1739	Uncharacterized protein family UPF0029
CLOSA_RS07960	COG1217	gtp-binding protein TYPA
CLOSA_RS07975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOSA_RS07980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLOSA_RS07995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLOSA_RS08000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLOSA_RS08005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLOSA_RS08010	COG0583	DNA-binding transcription factor activity
CLOSA_RS08030	COG0488	(ABC) transporter
CLOSA_RS08035	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLOSA_RS08040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLOSA_RS08040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLOSA_RS08045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLOSA_RS08050	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOSA_RS08055	COG1253	flavin adenine dinucleotide binding
CLOSA_RS08060	COG0217	transcriptional regulatory protein
CLOSA_RS08065	COG0840	transmembrane signaling receptor activity
CLOSA_RS08070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOSA_RS08080	COG1164	Oligoendopeptidase f
CLOSA_RS08090	COG0071	Belongs to the small heat shock protein (HSP20) family
CLOSA_RS08100	COG0284	orotidine-5'-phosphate decarboxylase activity
CLOSA_RS08105	COG0543	2 iron, 2 sulfur cluster binding
CLOSA_RS08110	COG0167	dihydroorotate dehydrogenase activity
CLOSA_RS08140	COG0840	transmembrane signaling receptor activity
CLOSA_RS08145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLOSA_RS08150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLOSA_RS08155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLOSA_RS08160	COG0151	Belongs to the GarS family
CLOSA_RS08185	COG1175	transmembrane transport
CLOSA_RS08190	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS08200	COG5609	conserved protein (DUF2294)
CLOSA_RS08215	COG1802	Transcriptional regulator
CLOSA_RS08220	COG1312	Catalyzes the dehydration of D-mannonate
CLOSA_RS08225	COG0246	Mannitol dehydrogenase
CLOSA_RS08240	COG1773	rubredoxin
CLOSA_RS08250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLOSA_RS08265	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOSA_RS08270	COG3845	ABC transporter
CLOSA_RS08275	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS08280	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS08285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLOSA_RS08290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLOSA_RS08330	COG1132	(ABC) transporter
CLOSA_RS08335	COG1132	(ABC) transporter
CLOSA_RS08340	COG4656	Part of a membrane complex involved in electron transport
CLOSA_RS08345	COG4658	electron transport chain
CLOSA_RS08350	COG4659	FMN binding
CLOSA_RS08355	COG4660	Part of a membrane complex involved in electron transport
CLOSA_RS08360	COG4657	Part of a membrane complex involved in electron transport
CLOSA_RS08365	COG2878	Part of a membrane complex involved in electron transport
CLOSA_RS08365	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOSA_RS08370	COG1904	glucuronate isomerase
CLOSA_RS08375	COG1609	Transcriptional regulator
CLOSA_RS08385	COG0800	Aldolase
CLOSA_RS08400	COG2207	Transcriptional regulator
CLOSA_RS08405	COG3842	ATPase activity
CLOSA_RS08435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOSA_RS08440	COG2207	Transcriptional regulator
CLOSA_RS08440	COG4753	response regulator
CLOSA_RS08445	COG2972	Histidine kinase
CLOSA_RS08460	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS08475	COG2971	BadF BadG BcrA BcrD
CLOSA_RS08480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOSA_RS08485	COG1328	CTP reductase activity
CLOSA_RS08490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLOSA_RS08500	COG3845	ABC transporter
CLOSA_RS08505	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS08510	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS08520	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOSA_RS08525	COG0813	purine-nucleoside phosphorylase activity
CLOSA_RS08540	COG0495	leucyl-tRNA aminoacylation
CLOSA_RS08560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOSA_RS08565	COG0628	permease
CLOSA_RS08590	COG0113	porphobilinogen synthase activity
CLOSA_RS08595	COG0613	PHP domain protein
CLOSA_RS08600	COG2720	vancomycin resistance protein
CLOSA_RS08605	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOSA_RS08605	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOSA_RS08605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOSA_RS08605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOSA_RS08620	COG1725	Transcriptional regulator
CLOSA_RS08650	COG2873	o-acetylhomoserine
CLOSA_RS08655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOSA_RS08685	COG2972	Histidine kinase
CLOSA_RS08690	COG2207	Transcriptional regulator
CLOSA_RS08690	COG4753	response regulator
CLOSA_RS08695	COG1653	transport
CLOSA_RS08700	COG1175	transmembrane transport
CLOSA_RS08710	COG3250	beta-galactosidase activity
CLOSA_RS08725	COG1132	(ABC) transporter
CLOSA_RS08730	COG1132	(ABC) transporter
CLOSA_RS08740	COG0210	DNA helicase
CLOSA_RS08805	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS08830	COG2801	Transposase and inactivated derivatives
CLOSA_RS08865	COG4626	Terminase
CLOSA_RS08865	COG1802	Transcriptional regulator
CLOSA_RS08880	COG4695	Portal protein
CLOSA_RS08885	COG0740	serine-type endopeptidase activity
CLOSA_RS08915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLOSA_RS08935	COG2315	Protein conserved in bacteria
CLOSA_RS08940	COG0488	(ABC) transporter
CLOSA_RS08955	COG2814	Major facilitator Superfamily
CLOSA_RS08975	COG2207	Transcriptional regulator
CLOSA_RS08975	COG3708	Transcriptional regulator
CLOSA_RS08985	COG3459	Glycosyltransferase 36 associated
CLOSA_RS08990	COG3459	Glycosyltransferase 36 associated
CLOSA_RS09015	COG2972	Histidine kinase
CLOSA_RS09020	COG4753	response regulator
CLOSA_RS09020	COG2207	Transcriptional regulator
CLOSA_RS09030	COG1175	transmembrane transport
CLOSA_RS09035	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS09040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOSA_RS09050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOSA_RS09055	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CLOSA_RS09070	COG0535	radical SAM domain protein
CLOSA_RS09080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSA_RS09085	COG1120	ATPase activity
CLOSA_RS09095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLOSA_RS09100	COG1301	dicarboxylic acid transport
CLOSA_RS09115	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLOSA_RS09120	COG3706	GGDEF domain
CLOSA_RS09135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS09135	COG2190	(PTS) system
CLOSA_RS09135	COG1263	PTS System
CLOSA_RS09140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLOSA_RS09145	COG1486	melibiose metabolic process
CLOSA_RS09155	COG0561	phosphatase activity
CLOSA_RS09165	COG1129	ABC transporter
CLOSA_RS09170	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS09180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLOSA_RS09185	COG1349	DNA-binding transcription factor activity
CLOSA_RS09195	COG1012	belongs to the aldehyde dehydrogenase family
CLOSA_RS09220	COG4869	propanediol catabolic process
CLOSA_RS09225	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOSA_RS09235	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSA_RS09240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLOSA_RS09245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLOSA_RS09250	COG1454	alcohol dehydrogenase
CLOSA_RS09255	COG2376	Dihydroxyacetone kinase
CLOSA_RS09305	COG0606	chelatase, subunit chli
CLOSA_RS09310	COG0758	DNA mediated transformation
CLOSA_RS09315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOSA_RS09325	COG0052	Belongs to the universal ribosomal protein uS2 family
CLOSA_RS09330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLOSA_RS09335	COG0601	transmembrane transport
CLOSA_RS09340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOSA_RS09345	COG0444	Belongs to the ABC transporter superfamily
CLOSA_RS09350	COG4608	Belongs to the ABC transporter superfamily
CLOSA_RS09355	COG4166	transmembrane transport
CLOSA_RS09360	COG4166	transmembrane transport
CLOSA_RS09365	COG0528	UMP kinase activity
CLOSA_RS09370	COG0233	cytoplasmic translational termination
CLOSA_RS09380	COG4589	Belongs to the CDS family
CLOSA_RS09385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLOSA_RS09390	COG0750	zinc metalloprotease
CLOSA_RS09395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLOSA_RS09420	COG2203	Gaf domain
CLOSA_RS09420	COG2199	diguanylate cyclase activity
CLOSA_RS09425	COG0280	phosphate acetyltransferase
CLOSA_RS09435	COG2124	cytochrome p450
CLOSA_RS09450	COG1254	Belongs to the acylphosphatase family
CLOSA_RS09465	COG0187	DNA topoisomerase II activity
CLOSA_RS09470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOSA_RS09495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLOSA_RS09500	COG0733	neurotransmitter:sodium symporter activity
CLOSA_RS09505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLOSA_RS09535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLOSA_RS09545	COG2848	UPF0210 protein
CLOSA_RS09565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CLOSA_RS09575	COG4869	propanediol catabolic process
CLOSA_RS09580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLOSA_RS09590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLOSA_RS09605	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOSA_RS09610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSA_RS09615	COG1869	D-ribose catabolic process
CLOSA_RS09620	COG1129	ABC transporter
CLOSA_RS09625	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS09645	COG0789	Transcriptional regulator
CLOSA_RS09650	COG1131	(ABC) transporter
CLOSA_RS09660	COG2207	Transcriptional regulator
CLOSA_RS09660	COG4753	response regulator
CLOSA_RS09665	COG2972	Histidine kinase
CLOSA_RS09670	COG1129	ABC transporter
CLOSA_RS09675	COG1129	ABC transporter
CLOSA_RS09680	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS09690	COG1940	carbohydrate kinase activity
CLOSA_RS09695	COG0534	Mate efflux family protein
CLOSA_RS09700	COG0416	fatty acid biosynthetic process
CLOSA_RS09705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOSA_RS09710	COG0571	ribonuclease III activity
CLOSA_RS09715	COG1196	nuclear chromosome segregation
CLOSA_RS09720	COG0552	protein localization to endoplasmic reticulum
CLOSA_RS09725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLOSA_RS09735	COG2207	Transcriptional regulator
CLOSA_RS09735	COG4753	response regulator
CLOSA_RS09740	COG2972	Histidine kinase
CLOSA_RS09755	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS09760	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CLOSA_RS09765	COG3119	arylsulfatase activity
CLOSA_RS09775	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS09810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLOSA_RS09810	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLOSA_RS09825	COG3715	PTS system
CLOSA_RS09830	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS09835	COG0434	BtpA family
CLOSA_RS09840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLOSA_RS09845	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CLOSA_RS09850	COG1561	YicC-like family, N-terminal region
CLOSA_RS09855	COG0194	GDP metabolic process
CLOSA_RS09860	COG1758	RNA polymerase activity
CLOSA_RS09865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOSA_RS09870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOSA_RS09875	COG1058	Belongs to the CinA family
CLOSA_RS09875	COG1546	Belongs to the CinA family
CLOSA_RS09900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLOSA_RS09910	COG1461	Dihydroxyacetone kinase
CLOSA_RS09915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLOSA_RS09925	COG0572	uridine kinase
CLOSA_RS09935	COG0742	ribosomal rna small subunit methyltransferase
CLOSA_RS09940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLOSA_RS09960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOSA_RS09960	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CLOSA_RS09965	COG1187	pseudouridine synthase activity
CLOSA_RS09980	COG0300	oxidoreductase activity
CLOSA_RS09990	COG0564	pseudouridine synthase activity
CLOSA_RS09995	COG3331	DNA recombination
CLOSA_RS10000	COG0124	histidyl-tRNA synthetase
CLOSA_RS10005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLOSA_RS10010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLOSA_RS10015	COG0131	Imidazoleglycerol-phosphate dehydratase
CLOSA_RS10020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLOSA_RS10035	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOSA_RS10050	COG3775	system Galactitol-specific IIC component
CLOSA_RS10065	COG2376	Dihydroxyacetone kinase
CLOSA_RS10090	COG1530	ribonuclease E activity
CLOSA_RS10095	COG0569	domain protein
CLOSA_RS10110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLOSA_RS10120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLOSA_RS10125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLOSA_RS10130	COG1534	Rna-binding protein
CLOSA_RS10135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLOSA_RS10140	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLOSA_RS10145	COG0799	negative regulation of ribosome biogenesis
CLOSA_RS10150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLOSA_RS10155	COG1388	LysM domain
CLOSA_RS10185	COG1316	TRANSCRIPTIONal
CLOSA_RS10195	COG0561	phosphatase activity
CLOSA_RS10205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CLOSA_RS10210	COG3457	Alanine racemase
CLOSA_RS10215	COG0626	cystathionine gamma-synthase activity
CLOSA_RS10220	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CLOSA_RS10255	COG0564	pseudouridine synthase activity
CLOSA_RS10260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLOSA_RS10265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLOSA_RS10270	COG1799	cell septum assembly
CLOSA_RS10275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLOSA_RS10290	COG1686	Belongs to the peptidase S11 family
CLOSA_RS10295	COG1803	Methylglyoxal synthase
CLOSA_RS10300	COG0772	Belongs to the SEDS family
CLOSA_RS10305	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLOSA_RS10310	COG2894	cell division
CLOSA_RS10320	COG0768	penicillin binding
CLOSA_RS10330	COG1792	Involved in formation and maintenance of cell shape
CLOSA_RS10345	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLOSA_RS10350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLOSA_RS10360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOSA_RS10365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOSA_RS10375	COG2723	6-phospho-beta-galactosidase activity
CLOSA_RS10380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS10380	COG2190	(PTS) system
CLOSA_RS10380	COG1263	PTS System
CLOSA_RS10385	COG3711	transcriptional antiterminator
CLOSA_RS10390	COG0488	(ABC) transporter
CLOSA_RS10400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLOSA_RS10405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLOSA_RS10410	COG4224	UPF0291 protein
CLOSA_RS10420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLOSA_RS10425	COG2081	HI0933 family
CLOSA_RS10445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLOSA_RS10450	COG1702	phosphate starvation-inducible protein PhoH
CLOSA_RS10465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLOSA_RS10470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOSA_RS10480	COG0328	RNA-DNA hybrid ribonuclease activity
CLOSA_RS10485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLOSA_RS10490	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLOSA_RS10500	COG1070	Carbohydrate kinase
CLOSA_RS10510	COG1063	alcohol dehydrogenase
CLOSA_RS10515	COG3842	ATPase activity
CLOSA_RS10520	COG3842	ATPase activity
CLOSA_RS10530	COG1175	transmembrane transport
CLOSA_RS10540	COG2207	Transcriptional regulator
CLOSA_RS10540	COG4753	response regulator
CLOSA_RS10545	COG2972	Histidine kinase
CLOSA_RS10555	COG0411	ABC transporter
CLOSA_RS10580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLOSA_RS10585	COG1160	GTP binding
CLOSA_RS10595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLOSA_RS10600	COG1496	oxidoreductase activity
CLOSA_RS10605	COG0792	nuclease activity
CLOSA_RS10610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLOSA_RS10615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CLOSA_RS10620	COG0681	Belongs to the peptidase S26 family
CLOSA_RS10625	COG0335	large ribosomal subunit rRNA binding
CLOSA_RS10630	COG0336	Belongs to the RNA methyltransferase TrmD family
CLOSA_RS10635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLOSA_RS10645	COG0228	four-way junction DNA binding
CLOSA_RS10650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLOSA_RS10660	COG0596	Alpha beta hydrolase
CLOSA_RS10670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLOSA_RS10675	COG0351	phosphomethylpyrimidine kinase
CLOSA_RS10685	COG1564	THIamine pyrophosphokinase
CLOSA_RS10690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLOSA_RS10700	COG0515	serine threonine protein kinase
CLOSA_RS10700	COG2815	serine threonine protein kinase
CLOSA_RS10705	COG0631	protein serine/threonine phosphatase activity
CLOSA_RS10710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLOSA_RS10715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOSA_RS10715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOSA_RS10720	COG2738	Putative neutral zinc metallopeptidase
CLOSA_RS10730	COG0242	peptide deformylase activity
CLOSA_RS10735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLOSA_RS10740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLOSA_RS10760	COG0740	serine-type endopeptidase activity
CLOSA_RS10765	COG0372	Belongs to the citrate synthase family
CLOSA_RS10770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLOSA_RS10785	COG1120	ATPase activity
CLOSA_RS10790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSA_RS10800	COG3608	succinylglutamate desuccinylase aspartoacylase
CLOSA_RS10800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLOSA_RS10810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOSA_RS10815	COG4120	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS10825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOSA_RS10830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CLOSA_RS10840	COG1307	EDD domain protein, DegV family
CLOSA_RS10845	COG5002	protein histidine kinase activity
CLOSA_RS10850	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS10855	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLOSA_RS10865	COG0577	efflux transmembrane transporter activity
CLOSA_RS10865	COG1136	(ABC) transporter
CLOSA_RS10870	COG0577	efflux transmembrane transporter activity
CLOSA_RS10870	COG1136	(ABC) transporter
CLOSA_RS10875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOSA_RS10885	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS10895	COG2357	RelA SpoT domain protein
CLOSA_RS10915	COG0671	phosphoesterase, PA-phosphatase related
CLOSA_RS10925	COG1346	cytolysis
CLOSA_RS10940	COG1263	PTS System
CLOSA_RS10940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS10945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS10950	COG2190	(PTS) system
CLOSA_RS10950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS10950	COG1263	PTS System
CLOSA_RS10955	COG3711	transcriptional antiterminator
CLOSA_RS10980	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CLOSA_RS11010	COG0138	bifunctional purine biosynthesis protein purh
CLOSA_RS11020	COG0577	efflux transmembrane transporter activity
CLOSA_RS11020	COG1136	(ABC) transporter
CLOSA_RS11030	COG1136	(ABC) transporter
CLOSA_RS11035	COG0540	Belongs to the ATCase OTCase family
CLOSA_RS11055	COG2384	SAM-dependent methyltransferase
CLOSA_RS11060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOSA_RS11065	COG0358	DNA primase activity
CLOSA_RS11070	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CLOSA_RS11080	COG1404	Belongs to the peptidase S8 family
CLOSA_RS11085	COG2385	sporulation resulting in formation of a cellular spore
CLOSA_RS11090	COG0628	permease
CLOSA_RS11110	COG2731	YhcH YjgK YiaL family protein
CLOSA_RS11115	COG3409	Peptidoglycan-binding domain 1 protein
CLOSA_RS11115	COG3773	Cell wall hydrolase
CLOSA_RS11120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLOSA_RS11125	COG0066	3-isopropylmalate dehydratase activity
CLOSA_RS11130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOSA_RS11135	COG0583	DNA-binding transcription factor activity
CLOSA_RS11140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLOSA_RS11165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLOSA_RS11170	COG0557	exoribonuclease II activity
CLOSA_RS11175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLOSA_RS11180	COG0148	phosphopyruvate hydratase activity
CLOSA_RS11185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOSA_RS11185	COG0072	phenylalanine-tRNA ligase activity
CLOSA_RS11190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLOSA_RS11205	COG1132	(ABC) transporter
CLOSA_RS11215	COG0583	DNA-binding transcription factor activity
CLOSA_RS11225	COG2252	PERMEase
CLOSA_RS11240	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CLOSA_RS11245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOSA_RS11245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOSA_RS11260	COG1051	belongs to the nudix hydrolase family
CLOSA_RS11265	COG0768	penicillin binding
CLOSA_RS11275	COG0826	peptidase U32
CLOSA_RS11285	COG2255	four-way junction helicase activity
CLOSA_RS11290	COG0632	four-way junction helicase activity
CLOSA_RS11300	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS11310	COG1278	Cold shock
CLOSA_RS11315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLOSA_RS11320	COG2226	methyltransferase
CLOSA_RS11325	COG0653	protein targeting
CLOSA_RS11335	COG1349	DNA-binding transcription factor activity
CLOSA_RS11340	COG3142	Participates in the control of copper homeostasis
CLOSA_RS11345	COG4608	Belongs to the ABC transporter superfamily
CLOSA_RS11350	COG0444	Belongs to the ABC transporter superfamily
CLOSA_RS11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOSA_RS11360	COG0601	transmembrane transport
CLOSA_RS11365	COG4166	transmembrane transport
CLOSA_RS11385	COG1404	Belongs to the peptidase S8 family
CLOSA_RS11395	COG1970	mechanosensitive ion channel activity
CLOSA_RS11440	COG1509	lysine 2,3-aminomutase activity
CLOSA_RS11455	COG1435	thymidine kinase activity
CLOSA_RS11470	COG0205	6-phosphofructokinase activity
CLOSA_RS11475	COG5001	Diguanylate cyclase
CLOSA_RS11475	COG3300	MHYT domain
CLOSA_RS11485	COG1879	ABC-type sugar transport system periplasmic component
CLOSA_RS11490	COG2972	Histidine kinase
CLOSA_RS11495	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS11500	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS11505	COG1129	ABC transporter
CLOSA_RS11510	COG1879	ABC-type sugar transport system periplasmic component
CLOSA_RS11515	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS11550	COG0561	phosphatase activity
CLOSA_RS11560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLOSA_RS11570	COG0390	transport system, permease component
CLOSA_RS11575	COG4619	ABC transporter
CLOSA_RS11625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLOSA_RS11635	COG0546	phosphoglycolate phosphatase activity
CLOSA_RS11640	COG0534	Mate efflux family protein
CLOSA_RS11650	COG2068	MobA-Related Protein
CLOSA_RS11670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLOSA_RS11720	COG1285	pathogenesis
CLOSA_RS11735	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS11740	COG1175	transmembrane transport
CLOSA_RS11775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLOSA_RS11780	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CLOSA_RS11790	COG1873	PFAM PRC-barrel domain
CLOSA_RS11805	COG1464	Belongs to the NlpA lipoprotein family
CLOSA_RS11810	COG2011	ABC-type metal ion transport system permease component
CLOSA_RS11815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOSA_RS11830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLOSA_RS11840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLOSA_RS11845	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLOSA_RS11850	COG1191	sigma factor activity
CLOSA_RS11860	COG1595	DNA-templated transcription, initiation
CLOSA_RS11865	COG1191	sigma factor activity
CLOSA_RS11895	COG0281	malic enzyme
CLOSA_RS11915	COG0765	amino acid transport
CLOSA_RS11925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLOSA_RS11930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLOSA_RS11935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLOSA_RS11945	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLOSA_RS11970	COG2954	triphosphatase activity
CLOSA_RS12005	COG4753	response regulator
CLOSA_RS12005	COG2207	Transcriptional regulator
CLOSA_RS12015	COG1492	cobalamin metabolic process
CLOSA_RS12025	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CLOSA_RS12035	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLOSA_RS12040	COG1082	Xylose isomerase domain protein TIM barrel
CLOSA_RS12050	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS12055	COG1175	transmembrane transport
CLOSA_RS12060	COG1653	transport
CLOSA_RS12070	COG4753	response regulator
CLOSA_RS12070	COG2207	Transcriptional regulator
CLOSA_RS12075	COG0534	Mate efflux family protein
CLOSA_RS12085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLOSA_RS12125	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CLOSA_RS12130	COG5426	von Willebrand factor, type A
CLOSA_RS12135	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS12145	COG3275	phosphorelay sensor kinase activity
CLOSA_RS12150	COG4753	response regulator
CLOSA_RS12150	COG2207	Transcriptional regulator
CLOSA_RS12160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CLOSA_RS12165	COG1797	cobyrinic acid a,c-diamide synthase activity
CLOSA_RS12200	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLOSA_RS12210	COG1983	PspC domain protein
CLOSA_RS12235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLOSA_RS12240	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS12245	COG3275	phosphorelay sensor kinase activity
CLOSA_RS12250	COG1686	Belongs to the peptidase S11 family
CLOSA_RS12265	COG0523	cobalamin synthesis protein
CLOSA_RS12280	COG0569	domain protein
CLOSA_RS12285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLOSA_RS12295	COG1316	TRANSCRIPTIONal
CLOSA_RS12300	COG0546	phosphoglycolate phosphatase activity
CLOSA_RS12305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOSA_RS12305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLOSA_RS12305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS12310	COG1105	Belongs to the carbohydrate kinase PfkB family
CLOSA_RS12325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CLOSA_RS12330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLOSA_RS12335	COG0697	spore germination
CLOSA_RS12345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOSA_RS12350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLOSA_RS12360	COG0148	phosphopyruvate hydratase activity
CLOSA_RS12375	COG0646	methionine synthase
CLOSA_RS12375	COG1410	methionine synthase
CLOSA_RS12385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLOSA_RS12400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLOSA_RS12410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLOSA_RS12415	COG0772	Belongs to the SEDS family
CLOSA_RS12420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLOSA_RS12425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOSA_RS12430	COG0768	penicillin binding
CLOSA_RS12435	COG0768	penicillin binding
CLOSA_RS12445	COG0275	rRNA processing
CLOSA_RS12450	COG2001	Belongs to the MraZ family
CLOSA_RS12455	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS12460	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS12465	COG3845	ABC transporter
CLOSA_RS12475	COG2207	Transcriptional regulator
CLOSA_RS12475	COG4753	response regulator
CLOSA_RS12480	COG2972	Histidine kinase
CLOSA_RS12490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLOSA_RS12495	COG0012	GTP binding
CLOSA_RS12505	COG3290	protein histidine kinase activity
CLOSA_RS12510	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS12525	COG0493	'glutamate synthase
CLOSA_RS12530	COG0070	glutamate synthase
CLOSA_RS12530	COG0069	glutamate synthase activity
CLOSA_RS12530	COG0067	glutamate synthase
CLOSA_RS12545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOSA_RS12550	COG1597	lipid kinase activity
CLOSA_RS12560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLOSA_RS12560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLOSA_RS12570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLOSA_RS12590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOSA_RS12595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLOSA_RS12595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOSA_RS12600	COG0534	Mate efflux family protein
CLOSA_RS12605	COG1959	2 iron, 2 sulfur cluster binding
CLOSA_RS12615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLOSA_RS12615	COG0426	domain, Protein
CLOSA_RS12620	COG0733	neurotransmitter:sodium symporter activity
CLOSA_RS12625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLOSA_RS12625	COG1328	CTP reductase activity
CLOSA_RS12630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLOSA_RS12640	COG0756	dUTP diphosphatase activity
CLOSA_RS12645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLOSA_RS12650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLOSA_RS12655	COG1408	metallophosphoesterase
CLOSA_RS12670	COG1686	Belongs to the peptidase S11 family
CLOSA_RS12675	COG0494	nUDIX hydrolase
CLOSA_RS12690	COG1216	Glycosyl transferase, family 2
CLOSA_RS12700	COG0549	Belongs to the carbamate kinase family
CLOSA_RS12710	COG0659	secondary active sulfate transmembrane transporter activity
CLOSA_RS12730	COG2033	superoxide reductase activity
CLOSA_RS12735	COG4753	response regulator
CLOSA_RS12735	COG2207	Transcriptional regulator
CLOSA_RS12740	COG2972	Histidine kinase
CLOSA_RS12755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOSA_RS12765	COG3842	ATPase activity
CLOSA_RS12770	COG1840	ABC-type Fe3 transport system, periplasmic component
CLOSA_RS12775	COG1132	(ABC) transporter
CLOSA_RS12790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOSA_RS12795	COG1126	abc transporter atp-binding protein
CLOSA_RS12800	COG4215	(ABC) transporter
CLOSA_RS12810	COG3447	MASE1 domain protein
CLOSA_RS12810	COG5002	protein histidine kinase activity
CLOSA_RS12810	COG5001	Diguanylate cyclase
CLOSA_RS12820	COG0037	tRNA processing
CLOSA_RS12825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLOSA_RS12850	COG1151	hydroxylamine reductase activity
CLOSA_RS12870	COG0840	transmembrane signaling receptor activity
CLOSA_RS12875	COG1929	Belongs to the glycerate kinase type-1 family
CLOSA_RS12880	COG2610	gluconate transmembrane transporter activity
CLOSA_RS12885	COG3835	regulator
CLOSA_RS12895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLOSA_RS12905	COG0159	tryptophan synthase activity
CLOSA_RS12920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS12940	COG1263	PTS System
CLOSA_RS12940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS12940	COG2190	(PTS) system
CLOSA_RS12945	COG2723	6-phospho-beta-galactosidase activity
CLOSA_RS12960	COG2832	Protein of unknown function (DUF454)
CLOSA_RS12975	COG2205	protein histidine kinase activity
CLOSA_RS12980	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS12985	COG2608	mercury ion transmembrane transporter activity
CLOSA_RS12995	COG2217	Heavy metal translocating P-type atpase
CLOSA_RS13000	COG1733	regulation of RNA biosynthetic process
CLOSA_RS13030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLOSA_RS13035	COG0840	transmembrane signaling receptor activity
CLOSA_RS13050	COG1151	hydroxylamine reductase activity
CLOSA_RS13065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOSA_RS13075	COG2207	Transcriptional regulator
CLOSA_RS13075	COG4753	response regulator
CLOSA_RS13105	COG1811	Na channel or pump
CLOSA_RS13110	COG1285	pathogenesis
CLOSA_RS13140	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOSA_RS13160	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CLOSA_RS13170	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS13185	COG0019	diaminopimelate decarboxylase activity
CLOSA_RS13195	COG1696	Membrane protein involved in D-alanine export
CLOSA_RS13205	COG0436	Aminotransferase
CLOSA_RS13215	COG0673	inositol 2-dehydrogenase activity
CLOSA_RS13225	COG0288	reversible hydration of carbon dioxide
CLOSA_RS13235	COG1051	belongs to the nudix hydrolase family
CLOSA_RS13240	COG2094	Belongs to the DNA glycosylase MPG family
CLOSA_RS13250	COG0717	Belongs to the dCTP deaminase family
CLOSA_RS13260	COG1794	racemase activity, acting on amino acids and derivatives
CLOSA_RS13275	COG1959	2 iron, 2 sulfur cluster binding
CLOSA_RS13320	COG0789	Transcriptional regulator
CLOSA_RS13325	COG4989	oxidoreductase activity
CLOSA_RS13330	COG1979	alcohol dehydrogenase
CLOSA_RS13335	COG0789	Transcriptional regulator
CLOSA_RS13345	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS13345	COG2972	Histidine kinase
CLOSA_RS13360	COG1342	Belongs to the UPF0251 family
CLOSA_RS13375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOSA_RS13400	COG1950	PFAM Membrane protein of
CLOSA_RS13425	COG0488	(ABC) transporter
CLOSA_RS13440	COG0513	Belongs to the DEAD box helicase family
CLOSA_RS13445	COG0275	rRNA processing
CLOSA_RS13450	COG1959	2 iron, 2 sulfur cluster binding
CLOSA_RS13460	COG4716	Myosin-crossreactive antigen
CLOSA_RS13465	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS13475	COG2508	Transcriptional regulator
CLOSA_RS13480	COG1671	Belongs to the UPF0178 family
CLOSA_RS13505	COG0798	PFAM Bile acid sodium symporter
CLOSA_RS13525	COG3695	enzyme binding
CLOSA_RS13570	COG1573	uracil-dna glycosylase
CLOSA_RS13585	COG0488	(ABC) transporter
CLOSA_RS13610	COG1733	regulation of RNA biosynthetic process
CLOSA_RS13620	COG1592	Rubrerythrin
CLOSA_RS13625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOSA_RS13630	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSA_RS13685	COG1121	(ABC) transporter
CLOSA_RS13695	COG0735	belongs to the Fur family
CLOSA_RS13705	COG0489	protein tyrosine kinase activity
CLOSA_RS13715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLOSA_RS13775	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS13780	COG5002	protein histidine kinase activity
CLOSA_RS13790	COG1136	(ABC) transporter
CLOSA_RS13820	COG0701	Predicted permease
CLOSA_RS13825	COG0640	Transcriptional regulator
CLOSA_RS13835	COG2199	diguanylate cyclase activity
CLOSA_RS13940	COG1397	ADP-ribosylglycohydrolase
CLOSA_RS14040	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS14050	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS14150	COG1253	flavin adenine dinucleotide binding
CLOSA_RS14165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOSA_RS14175	COG1131	(ABC) transporter
CLOSA_RS14235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLOSA_RS14255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLOSA_RS14265	COG2088	sporulation resulting in formation of a cellular spore
CLOSA_RS14315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLOSA_RS14330	COG2199	diguanylate cyclase activity
CLOSA_RS14340	COG0006	proline dipeptidase activity
CLOSA_RS14345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOSA_RS14350	COG0561	phosphatase activity
CLOSA_RS14385	COG4604	ABC transporter, ATP-binding protein
CLOSA_RS14390	COG4605	iron ion homeostasis
CLOSA_RS14395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSA_RS14415	COG1940	carbohydrate kinase activity
CLOSA_RS14420	COG1482	cell wall glycoprotein biosynthetic process
CLOSA_RS14435	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS14450	COG0849	cell division
CLOSA_RS14455	COG3546	catalase activity
CLOSA_RS14460	COG0726	polysaccharide deacetylase
CLOSA_RS14480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLOSA_RS14480	COG0723	plastoquinol--plastocyanin reductase activity
CLOSA_RS14505	COG2385	sporulation resulting in formation of a cellular spore
CLOSA_RS14510	COG0058	SHG alpha-glucan phosphorylase activity
CLOSA_RS14515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLOSA_RS14520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLOSA_RS14540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLOSA_RS14605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLOSA_RS14610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOSA_RS14615	COG0517	IMP dehydrogenase activity
CLOSA_RS14615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CLOSA_RS14625	COG2089	acid synthase
CLOSA_RS14630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOSA_RS14640	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOSA_RS14645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOSA_RS14655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLOSA_RS14660	COG0626	cystathionine gamma-synthase activity
CLOSA_RS14665	COG1959	2 iron, 2 sulfur cluster binding
CLOSA_RS14670	COG0583	DNA-binding transcription factor activity
CLOSA_RS14680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLOSA_RS14695	COG0791	NLP P60 protein
CLOSA_RS14700	COG0534	Mate efflux family protein
CLOSA_RS14705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOSA_RS14705	COG0493	'glutamate synthase
CLOSA_RS14725	COG0419	ATPase involved in DNA repair
CLOSA_RS14730	COG0420	3'-5' exonuclease activity
CLOSA_RS14735	COG0514	ATP-dependent DNA helicase (RecQ)
CLOSA_RS14750	COG2205	protein histidine kinase activity
CLOSA_RS14755	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS14765	COG0569	domain protein
CLOSA_RS14775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLOSA_RS14790	COG1395	domain, Protein
CLOSA_RS14810	COG2971	BadF BadG BcrA BcrD
CLOSA_RS14830	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CLOSA_RS14835	COG3616	Alanine racemase, N-terminal domain
CLOSA_RS14840	COG3250	beta-galactosidase activity
CLOSA_RS14845	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS14850	COG1175	transmembrane transport
CLOSA_RS14865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOSA_RS14880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOSA_RS14885	COG0504	CTP synthase activity
CLOSA_RS14915	COG0741	lytic transglycosylase activity
CLOSA_RS14915	COG0791	NLP P60 protein
CLOSA_RS14920	COG0196	riboflavin kinase activity
CLOSA_RS14925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLOSA_RS14930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLOSA_RS14935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLOSA_RS14940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLOSA_RS14950	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLOSA_RS14955	COG0195	Participates in both transcription termination and antitermination
CLOSA_RS14960	COG0779	Required for maturation of 30S ribosomal subunits
CLOSA_RS14965	COG1116	anion transmembrane transporter activity
CLOSA_RS14970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOSA_RS14975	COG1609	Transcriptional regulator
CLOSA_RS14980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOSA_RS14990	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS14995	COG1175	transmembrane transport
CLOSA_RS15010	COG3250	beta-galactosidase activity
CLOSA_RS15045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOSA_RS15050	COG2086	electron transfer activity
CLOSA_RS15055	COG1960	acyl-CoA dehydrogenase activity
CLOSA_RS15060	COG0318	PFAM AMP-dependent synthetase and ligase
CLOSA_RS15065	COG3949	Membrane
CLOSA_RS15075	COG2610	gluconate transmembrane transporter activity
CLOSA_RS15095	COG2186	Transcriptional regulator
CLOSA_RS15115	COG2188	Transcriptional regulator
CLOSA_RS15120	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS15125	COG3715	PTS system
CLOSA_RS15130	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS15140	COG1263	PTS System
CLOSA_RS15140	COG2190	(PTS) system
CLOSA_RS15140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS15160	COG2197	response regulator
CLOSA_RS15165	COG4585	Histidine kinase
CLOSA_RS15175	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS15180	COG1129	ABC transporter
CLOSA_RS15205	COG0840	transmembrane signaling receptor activity
CLOSA_RS15210	COG0488	(ABC) transporter
CLOSA_RS15220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLOSA_RS15225	COG1185	polyribonucleotide nucleotidyltransferase activity
CLOSA_RS15230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLOSA_RS15235	COG0402	S-adenosylhomocysteine deaminase activity
CLOSA_RS15240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOSA_RS15250	COG3842	ATPase activity
CLOSA_RS15265	COG0583	DNA-binding transcription factor activity
CLOSA_RS15290	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOSA_RS15295	COG1606	tRNA processing
CLOSA_RS15300	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLOSA_RS15305	COG1691	(AIR) carboxylase
CLOSA_RS15310	COG1124	(ABC) transporter
CLOSA_RS15320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOSA_RS15325	COG0601	transmembrane transport
CLOSA_RS15345	COG2176	DNA-directed DNA polymerase activity
CLOSA_RS15350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLOSA_RS15355	COG2801	Transposase and inactivated derivatives
CLOSA_RS15380	COG0840	transmembrane signaling receptor activity
CLOSA_RS15390	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSA_RS15395	COG1312	Catalyzes the dehydration of D-mannonate
CLOSA_RS15405	COG1687	branched-chain amino acid
CLOSA_RS15410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLOSA_RS15420	COG0840	transmembrane signaling receptor activity
CLOSA_RS15425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOSA_RS15435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLOSA_RS15445	COG0181	hydroxymethylbilane synthase activity
CLOSA_RS15460	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CLOSA_RS15470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLOSA_RS15475	COG4565	transcriptional regulatory protein
CLOSA_RS15485	COG1126	abc transporter atp-binding protein
CLOSA_RS15490	COG0765	amino acid transport
CLOSA_RS15575	COG2088	sporulation resulting in formation of a cellular spore
CLOSA_RS15585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLOSA_RS15640	COG2226	methyltransferase
CLOSA_RS15640	COG1073	alpha beta
CLOSA_RS15690	COG0741	lytic transglycosylase activity
CLOSA_RS15690	COG1196	nuclear chromosome segregation
CLOSA_RS15690	COG0739	heme binding
CLOSA_RS15785	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS15790	COG2205	protein histidine kinase activity
CLOSA_RS15885	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOSA_RS15925	COG0542	response to heat
CLOSA_RS15940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOSA_RS15940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOSA_RS15970	COG1174	glycine betaine transport
CLOSA_RS15975	COG0517	IMP dehydrogenase activity
CLOSA_RS15975	COG1125	glycine betaine transport
CLOSA_RS15995	COG0393	Putative heavy-metal-binding
CLOSA_RS16040	COG0277	FAD linked oxidase domain protein
CLOSA_RS16045	COG1846	Transcriptional regulator
CLOSA_RS16050	COG0386	Belongs to the glutathione peroxidase family
CLOSA_RS16055	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSA_RS16065	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CLOSA_RS16070	COG1242	4 iron, 4 sulfur cluster binding
CLOSA_RS16090	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS16095	COG1175	transmembrane transport
CLOSA_RS16105	COG2188	Transcriptional regulator
CLOSA_RS16120	COG0326	Molecular chaperone. Has ATPase activity
CLOSA_RS16130	COG1362	aminopeptidase activity
CLOSA_RS16145	COG0561	phosphatase activity
CLOSA_RS16160	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CLOSA_RS16170	COG0297	glycogen (starch) synthase activity
CLOSA_RS16175	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS16180	COG0750	zinc metalloprotease
CLOSA_RS16190	COG0840	transmembrane signaling receptor activity
CLOSA_RS16195	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS16205	COG0497	DNA recombination
CLOSA_RS16210	COG1438	arginine binding
CLOSA_RS16215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLOSA_RS16220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLOSA_RS16225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLOSA_RS16240	COG1570	exodeoxyribonuclease VII activity
CLOSA_RS16255	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CLOSA_RS16260	COG5001	Diguanylate cyclase
CLOSA_RS16265	COG1302	Protein conserved in bacteria
CLOSA_RS16305	COG3854	ATPases associated with a variety of cellular activities
CLOSA_RS16325	COG0450	alkyl hydroperoxide reductase
CLOSA_RS16345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLOSA_RS16365	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS16370	COG1555	photosystem II stabilization
CLOSA_RS16370	COG1596	polysaccharide export
CLOSA_RS16380	COG3859	Proton-coupled thiamine transporter YuaJ
CLOSA_RS16385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLOSA_RS16390	COG3404	Formiminotransferase-cyclodeaminase
CLOSA_RS16400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSA_RS16405	COG1609	Transcriptional regulator
CLOSA_RS16420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLOSA_RS16430	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS16435	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS16440	COG3845	ABC transporter
CLOSA_RS16445	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOSA_RS16460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLOSA_RS16465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLOSA_RS16470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLOSA_RS16485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLOSA_RS16500	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLOSA_RS16505	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLOSA_RS16510	COG0482	sulfurtransferase activity
CLOSA_RS16515	COG0822	iron-sulfur transferase activity
CLOSA_RS16530	COG3585	molybdate ion transport
CLOSA_RS16535	COG3842	ATPase activity
CLOSA_RS16540	COG4149	molybdate abc transporter
CLOSA_RS16550	COG1910	domain protein
CLOSA_RS16595	COG1357	PFAM Pentapeptide repeats (8 copies)
CLOSA_RS16615	COG2801	Transposase and inactivated derivatives
CLOSA_RS16620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLOSA_RS16625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLOSA_RS16630	COG1187	pseudouridine synthase activity
CLOSA_RS16645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOSA_RS16655	COG2169	Transcriptional regulator
CLOSA_RS16660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CLOSA_RS16665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLOSA_RS16680	COG0129	dihydroxy-acid dehydratase activity
CLOSA_RS16695	COG2801	Transposase and inactivated derivatives
CLOSA_RS16700	COG0785	Cytochrome C biogenesis protein
CLOSA_RS16705	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOSA_RS16720	COG4753	response regulator
CLOSA_RS16720	COG2207	Transcriptional regulator
CLOSA_RS16730	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS16735	COG1175	transmembrane transport
CLOSA_RS16785	COG0768	penicillin binding
CLOSA_RS16800	COG0538	isocitrate dehydrogenase activity
CLOSA_RS16810	COG0456	acetyltransferase
CLOSA_RS16810	COG1846	Transcriptional regulator
CLOSA_RS16815	COG0583	DNA-binding transcription factor activity
CLOSA_RS16820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOSA_RS16835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLOSA_RS16840	COG0017	Asparaginyl-tRNA synthetase
CLOSA_RS16845	COG0534	Mate efflux family protein
CLOSA_RS16850	COG3688	RNA-binding protein containing a PIN domain
CLOSA_RS16855	COG1971	Probably functions as a manganese efflux pump
CLOSA_RS16860	COG0366	Alpha amylase catalytic
CLOSA_RS16865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS16865	COG1263	PTS System
CLOSA_RS16870	COG2188	Transcriptional regulator
CLOSA_RS16875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOSA_RS16900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS16900	COG1263	PTS System
CLOSA_RS16915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CLOSA_RS16920	COG1968	undecaprenyl-diphosphatase activity
CLOSA_RS16930	COG0107	imidazoleglycerol-phosphate synthase activity
CLOSA_RS16935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLOSA_RS16955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLOSA_RS16970	COG1131	(ABC) transporter
CLOSA_RS16975	COG1725	Transcriptional regulator
CLOSA_RS17035	COG0840	transmembrane signaling receptor activity
CLOSA_RS17060	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CLOSA_RS17065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOSA_RS17085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLOSA_RS17130	COG2207	Transcriptional regulator
CLOSA_RS17130	COG3708	Transcriptional regulator
CLOSA_RS17135	COG1132	(ABC) transporter
CLOSA_RS17140	COG1132	(ABC) transporter
CLOSA_RS17185	COG2201	protein-glutamate methylesterase activity
CLOSA_RS17190	COG0741	lytic transglycosylase activity
CLOSA_RS17190	COG1196	nuclear chromosome segregation
CLOSA_RS17190	COG0739	heme binding
CLOSA_RS17210	COG2257	FlhB HrpN YscU SpaS Family
CLOSA_RS17220	COG0643	Histidine kinase
CLOSA_RS17220	COG2198	Histidine kinase
CLOSA_RS17235	COG2201	protein-glutamate methylesterase activity
CLOSA_RS17265	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLOSA_RS17270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLOSA_RS17295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLOSA_RS17300	COG1192	Involved in chromosome partitioning
CLOSA_RS17310	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CLOSA_RS17315	COG0835	chemotaxis
CLOSA_RS17315	COG0784	Response regulator, receiver
CLOSA_RS17320	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLOSA_RS17325	COG1776	CheC inhibitor of MCP methylation
CLOSA_RS17330	COG4786	Flagellar basal body rod
CLOSA_RS17335	COG4786	Flagellar basal body rod
CLOSA_RS17340	COG1191	sigma factor activity
CLOSA_RS17345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOSA_RS17350	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOSA_RS17355	COG1684	flagellar biosynthetic protein fliR
CLOSA_RS17365	COG1338	Plays a role in the flagellum-specific transport system
CLOSA_RS17375	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOSA_RS17375	COG1776	CheC inhibitor of MCP methylation
CLOSA_RS17380	COG1558	bacterial-type flagellum-dependent cell motility
CLOSA_RS17385	COG2201	protein-glutamate methylesterase activity
CLOSA_RS17390	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOSA_RS17395	COG1360	Flagellar Motor Protein
CLOSA_RS17440	COG1157	protein secretion by the type III secretion system
CLOSA_RS17450	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOSA_RS17465	COG1815	bacterial-type flagellum-dependent cell motility
CLOSA_RS17485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLOSA_RS17495	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CLOSA_RS17505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLOSA_RS17530	COG5002	protein histidine kinase activity
CLOSA_RS17535	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS17540	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CLOSA_RS17545	COG0840	transmembrane signaling receptor activity
CLOSA_RS17555	COG0210	DNA helicase
CLOSA_RS17595	COG3942	CHAP domain
CLOSA_RS17595	COG1388	LysM domain
CLOSA_RS17615	COG2204	response regulator
CLOSA_RS17655	COG1704	LemA family
CLOSA_RS17710	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS17730	COG1309	transcriptional regulator
CLOSA_RS17800	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CLOSA_RS17860	COG2088	sporulation resulting in formation of a cellular spore
CLOSA_RS17935	COG0798	PFAM Bile acid sodium symporter
CLOSA_RS17995	COG1475	DNA binding
CLOSA_RS18000	COG1192	Involved in chromosome partitioning
CLOSA_RS18025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLOSA_RS18045	COG1979	alcohol dehydrogenase
CLOSA_RS18055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOSA_RS18065	COG0737	Belongs to the 5'-nucleotidase family
CLOSA_RS18070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLOSA_RS18075	COG0124	histidyl-tRNA synthetase
CLOSA_RS18080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOSA_RS18085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOSA_RS18090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLOSA_RS18095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CLOSA_RS18100	COG1472	Belongs to the glycosyl hydrolase 3 family
CLOSA_RS18105	COG3876	Protein conserved in bacteria
CLOSA_RS18120	COG1486	melibiose metabolic process
CLOSA_RS18125	COG1940	carbohydrate kinase activity
CLOSA_RS18135	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS18140	COG1175	transmembrane transport
CLOSA_RS18145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLOSA_RS18175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOSA_RS18180	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS18195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLOSA_RS18200	COG1349	DNA-binding transcription factor activity
CLOSA_RS18205	COG2610	gluconate transmembrane transporter activity
CLOSA_RS18215	COG3395	kinase activity
CLOSA_RS18230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLOSA_RS18230	COG0512	Glutamine amidotransferase of anthranilate synthase
CLOSA_RS18235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLOSA_RS18240	COG0134	indole-3-glycerol-phosphate synthase activity
CLOSA_RS18250	COG0133	tryptophan synthase activity
CLOSA_RS18255	COG0159	tryptophan synthase activity
CLOSA_RS18260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLOSA_RS18270	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLOSA_RS18280	COG0351	phosphomethylpyrimidine kinase
CLOSA_RS18290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSA_RS18295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSA_RS18300	COG2723	6-phospho-beta-galactosidase activity
CLOSA_RS18305	COG3711	transcriptional antiterminator
CLOSA_RS18305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS18310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CLOSA_RS18315	COG1793	dna ligase
CLOSA_RS18335	COG2188	Transcriptional regulator
CLOSA_RS18340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSA_RS18345	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS18350	COG1175	transmembrane transport
CLOSA_RS18355	COG1653	transport
CLOSA_RS18360	COG2222	sugar isomerase
CLOSA_RS18365	COG3384	dioxygenase
CLOSA_RS18390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLOSA_RS18395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLOSA_RS18400	COG0028	Belongs to the TPP enzyme family
CLOSA_RS18405	COG0129	dihydroxy-acid dehydratase activity
CLOSA_RS18430	COG1131	(ABC) transporter
CLOSA_RS18445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLOSA_RS18460	COG0017	Asparaginyl-tRNA synthetase
CLOSA_RS18475	COG2378	regulation of single-species biofilm formation
CLOSA_RS18490	COG4974	Belongs to the 'phage' integrase family
CLOSA_RS18500	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOSA_RS18545	COG2315	Protein conserved in bacteria
CLOSA_RS18620	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLOSA_RS18625	COG3843	relaxase mobilization nuclease domain protein
CLOSA_RS18670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOSA_RS18670	COG0551	DNA topoisomerase type I activity
CLOSA_RS18695	COG1388	LysM domain
CLOSA_RS18695	COG0791	NLP P60 protein
CLOSA_RS18745	COG1475	DNA binding
CLOSA_RS18760	COG3617	BRO family, N-terminal domain
CLOSA_RS18765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLOSA_RS18770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLOSA_RS18780	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLOSA_RS18790	COG1122	ATPase activity
CLOSA_RS18810	COG0203	ribosomal protein L17
CLOSA_RS18815	COG0202	RNA polymerase activity
CLOSA_RS18820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOSA_RS18825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLOSA_RS18830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLOSA_RS18835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLOSA_RS18850	COG0563	adenylate kinase activity
CLOSA_RS18855	COG0201	protein transport
CLOSA_RS18865	COG1841	ribosomal large subunit assembly
CLOSA_RS18870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLOSA_RS18875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLOSA_RS18880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLOSA_RS18885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLOSA_RS18890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLOSA_RS18910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLOSA_RS18915	COG0255	Belongs to the universal ribosomal protein uL29 family
CLOSA_RS18920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLOSA_RS18930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLOSA_RS18940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLOSA_RS18955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLOSA_RS18960	COG0051	transcription antitermination factor activity, RNA binding
CLOSA_RS18970	COG0116	Belongs to the methyltransferase superfamily
CLOSA_RS18970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLOSA_RS18985	COG1404	Belongs to the peptidase S8 family
CLOSA_RS18995	COG1263	PTS System
CLOSA_RS18995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS19005	COG1737	Transcriptional regulator
CLOSA_RS19020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLOSA_RS19025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOSA_RS19030	COG0049	tRNA binding
CLOSA_RS19035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLOSA_RS19040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLOSA_RS19045	COG0085	RNA polymerase activity
CLOSA_RS19065	COG1213	nucleotidyl transferase
CLOSA_RS19080	COG0463	Glycosyl transferase, family 2
CLOSA_RS19100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLOSA_RS19105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLOSA_RS19140	COG1682	transport, permease protein
CLOSA_RS19150	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS19160	COG4213	ABC transporter substrate-binding protein
CLOSA_RS19170	COG0733	neurotransmitter:sodium symporter activity
CLOSA_RS19180	COG4213	ABC transporter substrate-binding protein
CLOSA_RS19185	COG2207	Transcriptional regulator
CLOSA_RS19185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOSA_RS19215	COG1215	transferase activity, transferring glycosyl groups
CLOSA_RS19260	COG1216	Glycosyl transferase, family 2
CLOSA_RS19270	COG1442	glycosyl transferase family 8
CLOSA_RS19275	COG0562	UDP-galactopyranose mutase
CLOSA_RS19280	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOSA_RS19300	COG0673	inositol 2-dehydrogenase activity
CLOSA_RS19305	COG1609	Transcriptional regulator
CLOSA_RS19310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOSA_RS19315	COG3853	Toxic anion resistance protein (TelA)
CLOSA_RS19325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOSA_RS19330	COG4509	Sortase family
CLOSA_RS19340	COG1803	Methylglyoxal synthase
CLOSA_RS19370	COG2723	6-phospho-beta-galactosidase activity
CLOSA_RS19375	COG3833	ABC-type maltose transport systems, permease component
CLOSA_RS19380	COG1175	transmembrane transport
CLOSA_RS19390	COG1609	Transcriptional regulator
CLOSA_RS19395	COG3459	Glycosyltransferase 36 associated
CLOSA_RS19400	COG0450	alkyl hydroperoxide reductase
CLOSA_RS19520	COG0668	transmembrane transport
CLOSA_RS19525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLOSA_RS19535	COG0681	Belongs to the peptidase S26 family
CLOSA_RS19540	COG2084	Dehydrogenase
CLOSA_RS19545	COG0698	ribose 5-phosphate isomerase
CLOSA_RS19560	COG1396	sequence-specific DNA binding
CLOSA_RS19565	COG3842	ATPase activity
CLOSA_RS19570	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOSA_RS19575	COG1177	transmembrane transport
CLOSA_RS19580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CLOSA_RS19610	COG0582	viral genome integration into host DNA
CLOSA_RS19630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOSA_RS19635	COG0346	lactoylglutathione lyase activity
CLOSA_RS19640	COG3706	GGDEF domain
CLOSA_RS19660	COG5001	Diguanylate cyclase
CLOSA_RS19670	COG3973	AAA domain
CLOSA_RS19690	COG0513	Belongs to the DEAD box helicase family
CLOSA_RS19695	COG2323	membrane
CLOSA_RS19700	COG2323	membrane
CLOSA_RS19705	COG0657	acetylesterase activity
CLOSA_RS19710	COG1609	Transcriptional regulator
CLOSA_RS19715	COG2223	nitrite transmembrane transporter activity
CLOSA_RS19725	COG1960	acyl-CoA dehydrogenase activity
CLOSA_RS19735	COG1024	Enoyl-CoA hydratase
CLOSA_RS19745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLOSA_RS19750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLOSA_RS19765	COG0318	PFAM AMP-dependent synthetase and ligase
CLOSA_RS19775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOSA_RS19785	COG4716	Myosin-crossreactive antigen
CLOSA_RS19795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLOSA_RS19800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLOSA_RS19805	COG0513	Belongs to the DEAD box helicase family
CLOSA_RS19810	COG0598	Magnesium transport protein CorA
CLOSA_RS19825	COG0765	amino acid transport
CLOSA_RS19830	COG0765	amino acid transport
CLOSA_RS19835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOSA_RS19840	COG1126	abc transporter atp-binding protein
CLOSA_RS19845	COG4608	Belongs to the ABC transporter superfamily
CLOSA_RS19850	COG0444	Belongs to the ABC transporter superfamily
CLOSA_RS19855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOSA_RS19860	COG0601	transmembrane transport
CLOSA_RS19865	COG0747	negative chemotaxis
CLOSA_RS19870	COG1285	pathogenesis
CLOSA_RS19880	COG0673	inositol 2-dehydrogenase activity
CLOSA_RS19885	COG1082	Xylose isomerase domain protein TIM barrel
CLOSA_RS19890	COG3962	Belongs to the TPP enzyme family
CLOSA_RS19895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSA_RS19900	COG1012	belongs to the aldehyde dehydrogenase family
CLOSA_RS19910	COG1349	DNA-binding transcription factor activity
CLOSA_RS19925	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS19930	COG5002	protein histidine kinase activity
CLOSA_RS19935	COG1063	alcohol dehydrogenase
CLOSA_RS19950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS19950	COG3711	transcriptional antiterminator
CLOSA_RS19955	COG2213	PTS system mannitol-specific
CLOSA_RS19960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS19960	COG2213	PTS system mannitol-specific
CLOSA_RS19965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLOSA_RS19970	COG1115	amino acid carrier protein
CLOSA_RS19985	COG1175	transmembrane transport
CLOSA_RS20005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLOSA_RS20025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLOSA_RS20050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLOSA_RS20055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLOSA_RS20060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLOSA_RS20065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLOSA_RS20070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOSA_RS20075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLOSA_RS20080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOSA_RS20105	COG4869	propanediol catabolic process
CLOSA_RS20110	COG1012	belongs to the aldehyde dehydrogenase family
CLOSA_RS20110	COG1454	alcohol dehydrogenase
CLOSA_RS20115	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOSA_RS20160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLOSA_RS20165	COG1882	Formate acetyltransferase
CLOSA_RS20175	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOSA_RS20205	COG4978	Transcriptional regulator
CLOSA_RS20205	COG0789	Transcriptional regulator
CLOSA_RS20210	COG3118	belongs to the thioredoxin family
CLOSA_RS20225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOSA_RS20230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLOSA_RS20235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS20240	COG3715	PTS system
CLOSA_RS20245	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS20250	COG2222	sugar isomerase
CLOSA_RS20255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSA_RS20260	COG2188	Transcriptional regulator
CLOSA_RS20275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLOSA_RS20310	COG0582	viral genome integration into host DNA
CLOSA_RS20360	COG2033	superoxide reductase activity
CLOSA_RS20365	COG2188	Transcriptional regulator
CLOSA_RS20370	COG2188	Transcriptional regulator
CLOSA_RS20375	COG0840	transmembrane signaling receptor activity
CLOSA_RS20395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOSA_RS20405	COG0037	tRNA processing
CLOSA_RS20430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLOSA_RS20440	COG3956	TIGRFAM MazG family protein
CLOSA_RS20455	COG2002	toxin-antitoxin pair type II binding
CLOSA_RS20465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLOSA_RS20470	COG0193	aminoacyl-tRNA hydrolase activity
CLOSA_RS20490	COG1175	transmembrane transport
CLOSA_RS20495	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS20505	COG2081	HI0933 family
CLOSA_RS20510	COG0561	phosphatase activity
CLOSA_RS20515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOSA_RS20520	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLOSA_RS20525	COG1362	aminopeptidase activity
CLOSA_RS20530	COG1490	D-aminoacyl-tRNA deacylase activity
CLOSA_RS20535	COG0584	glycerophosphoryl diester phosphodiesterase
CLOSA_RS20540	COG2357	RelA SpoT domain protein
CLOSA_RS20550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOSA_RS20565	COG1592	Rubrerythrin
CLOSA_RS20565	COG1773	rubredoxin
CLOSA_RS20570	COG1592	Rubrerythrin
CLOSA_RS20580	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLOSA_RS20585	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CLOSA_RS20590	COG0584	glycerophosphoryl diester phosphodiesterase
CLOSA_RS20600	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSA_RS20610	COG1285	pathogenesis
CLOSA_RS20615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLOSA_RS20620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLOSA_RS20625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOSA_RS20630	COG2252	PERMEase
CLOSA_RS20635	COG2188	Transcriptional regulator
CLOSA_RS20640	COG1854	S-ribosylhomocysteine lyase activity
CLOSA_RS20645	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS20660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CLOSA_RS20675	COG3958	Transketolase
CLOSA_RS20680	COG3959	Transketolase, thiamine diphosphate binding domain
CLOSA_RS20695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS20700	COG1523	belongs to the glycosyl hydrolase 13 family
CLOSA_RS20705	COG0488	(ABC) transporter
CLOSA_RS20710	COG0708	Exodeoxyribonuclease III
CLOSA_RS20720	COG0310	cobalt ion transport
CLOSA_RS20725	COG1122	ATPase activity
CLOSA_RS20735	COG0488	(ABC) transporter
CLOSA_RS20750	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CLOSA_RS20755	COG1126	abc transporter atp-binding protein
CLOSA_RS20765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOSA_RS20775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLOSA_RS20790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOSA_RS20810	COG2155	Conserved Protein
CLOSA_RS20845	COG1388	LysM domain
CLOSA_RS20845	COG3858	chitin binding
CLOSA_RS20850	COG3942	CHAP domain
CLOSA_RS20850	COG1388	LysM domain
CLOSA_RS20870	COG0534	Mate efflux family protein
CLOSA_RS20875	COG0791	NLP P60 protein
CLOSA_RS20875	COG1388	LysM domain
CLOSA_RS20885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLOSA_RS20890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLOSA_RS20895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLOSA_RS20905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOSA_RS20915	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLOSA_RS20920	COG0356	it plays a direct role in the translocation of protons across the membrane
CLOSA_RS20925	COG2267	carboxylic ester hydrolase activity
CLOSA_RS20935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLOSA_RS20940	COG1121	(ABC) transporter
CLOSA_RS20945	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLOSA_RS20965	COG2222	sugar isomerase
CLOSA_RS20970	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS20975	COG3715	PTS system
CLOSA_RS20995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLOSA_RS21045	COG1269	ATP hydrolysis coupled proton transport
CLOSA_RS21070	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CLOSA_RS21075	COG1394	ATPase activity, coupled to movement of substances
CLOSA_RS21095	COG3842	ATPase activity
CLOSA_RS21100	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOSA_RS21105	COG1840	ABC-type Fe3 transport system, periplasmic component
CLOSA_RS21110	COG1486	melibiose metabolic process
CLOSA_RS21115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSA_RS21130	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS21135	COG1175	transmembrane transport
CLOSA_RS21140	COG1653	transport
CLOSA_RS21145	COG2972	Histidine kinase
CLOSA_RS21150	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS21160	COG3848	Pyruvate phosphate dikinase
CLOSA_RS21160	COG0574	Belongs to the PEP-utilizing enzyme family
CLOSA_RS21165	COG1131	(ABC) transporter
CLOSA_RS21185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLOSA_RS21195	COG0372	Belongs to the citrate synthase family
CLOSA_RS21200	COG2860	membrane
CLOSA_RS21210	COG1686	Belongs to the peptidase S11 family
CLOSA_RS21215	COG2205	protein histidine kinase activity
CLOSA_RS21220	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS21235	COG0658	competence protein
CLOSA_RS21235	COG2333	competence protein COMEC
CLOSA_RS21245	COG1175	transmembrane transport
CLOSA_RS21250	COG0395	ABC-type sugar transport system, permease component
CLOSA_RS21255	COG1653	transport
CLOSA_RS21260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOSA_RS21295	COG0840	transmembrane signaling receptor activity
CLOSA_RS21300	COG2267	carboxylic ester hydrolase activity
CLOSA_RS21315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOSA_RS21325	COG1252	NADH dehydrogenase
CLOSA_RS21330	COG0142	geranyltranstransferase activity
CLOSA_RS21345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLOSA_RS21350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLOSA_RS21355	COG0163	prenyltransferase activity
CLOSA_RS21385	COG0640	Transcriptional regulator
CLOSA_RS21400	COG3842	ATPase activity
CLOSA_RS21415	COG4753	response regulator
CLOSA_RS21415	COG2207	Transcriptional regulator
CLOSA_RS21425	COG3716	PTS system mannose fructose sorbose family IID component
CLOSA_RS21430	COG3715	PTS system
CLOSA_RS21435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSA_RS21435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOSA_RS21450	COG2188	Transcriptional regulator
CLOSA_RS21455	COG2188	Transcriptional regulator
CLOSA_RS21475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLOSA_RS21485	COG1268	BioY protein
CLOSA_RS21495	COG1012	belongs to the aldehyde dehydrogenase family
CLOSA_RS21495	COG1454	alcohol dehydrogenase
CLOSA_RS21510	COG1475	DNA binding
CLOSA_RS21515	COG1192	Involved in chromosome partitioning
CLOSA_RS21525	COG0357	Ribosomal RNA small subunit methyltransferase G
CLOSA_RS21530	COG0445	tRNA wobble uridine modification
CLOSA_RS21535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLOSA_RS21540	COG1847	R3H domain protein
CLOSA_RS21545	COG0706	membrane insertase activity
CLOSA_RS21550	COG0594	ribonuclease P activity
CLOSA_RS21555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLOSA_RS21565	COG4684	Psort location CytoplasmicMembrane, score
CLOSA_RS21605	COG2186	Transcriptional regulator
CLOSA_RS21630	COG1316	TRANSCRIPTIONal
CLOSA_RS21660	COG1652	LysM domain
CLOSA_RS21700	COG3645	SOS response
CLOSA_RS21700	COG3646	Phage regulatory protein
CLOSA_RS21710	COG0745	RESPONSE REGULATOR receiver
CLOSA_RS21710	COG2972	Histidine kinase
CLOSA_RS21755	COG3275	phosphorelay sensor kinase activity
CLOSA_RS21760	COG0840	transmembrane signaling receptor activity
CLOSA_RS21770	COG3437	response regulator, receiver
CLOSA_RS21775	COG2340	Cysteine-rich secretory protein family
CLOSA_RS21785	COG0642	Histidine kinase
CLOSA_RS21785	COG5002	protein histidine kinase activity
CLOSA_RS21795	COG3279	Response regulator of the LytR AlgR family
CLOSA_RS21810	COG2199	diguanylate cyclase activity
CLOSA_RS21810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOSA_RS21865	COG0840	transmembrane signaling receptor activity
CLOSA_RS21875	COG2972	Histidine kinase
CLOSA_RS21880	COG0726	polysaccharide deacetylase
CLOSA_RS21910	COG0463	Glycosyl transferase, family 2
CLOSA_RS21960	COG3706	GGDEF domain
CLOSA_RS21965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOSA_RS21970	COG0840	transmembrane signaling receptor activity
CLOSA_RS21975	COG0840	transmembrane signaling receptor activity
CLOSA_RS21985	COG5492	domain, Protein