locus-tag	class	description
CLOSPO_RS02025	COG0577	efflux transmembrane transporter activity
CLOSPO_RS02400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOSPO_RS02705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLOSPO_RS02780	COG2208	phosphoserine phosphatase activity
CLOSPO_RS02910	COG0423	glycine-tRNA ligase activity
CLOSPO_RS03120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOSPO_RS03210	COG1074	ATP-dependent DNA helicase activity
CLOSPO_RS03425	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLOSPO_RS03460	COG0420	3'-5' exonuclease activity
CLOSPO_RS03500	COG2217	Heavy metal translocating P-type atpase
CLOSPO_RS03505	COG2217	Heavy metal translocating P-type atpase
CLOSPO_RS04040	COG1132	(ABC) transporter
CLOSPO_RS04075	COG1307	EDD domain protein, DegV family
CLOSPO_RS04155	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS04440	COG3711	transcriptional antiterminator
CLOSPO_RS04555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLOSPO_RS04705	COG0488	(ABC) transporter
CLOSPO_RS06355	COG1129	ABC transporter
CLOSPO_RS06550	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSPO_RS06565	COG2271	Major facilitator Superfamily
CLOSPO_RS06760	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOSPO_RS06845	COG0626	cystathionine gamma-synthase activity
CLOSPO_RS07215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOSPO_RS07685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLOSPO_RS07695	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLOSPO_RS07695	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLOSPO_RS07825	COG3973	AAA domain
CLOSPO_RS07885	COG3459	Glycosyltransferase 36 associated
CLOSPO_RS08010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLOSPO_RS08135	COG0318	PFAM AMP-dependent synthetase and ligase
CLOSPO_RS08460	COG1882	Formate acetyltransferase
CLOSPO_RS08755	COG0285	dihydrofolate synthase activity
CLOSPO_RS08820	COG4166	transmembrane transport
CLOSPO_RS09045	COG1982	Orn Lys Arg decarboxylase major
CLOSPO_RS09080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOSPO_RS09850	COG1420	regulation of RNA biosynthetic process
CLOSPO_RS10080	COG1253	flavin adenine dinucleotide binding
CLOSPO_RS10450	COG2190	(PTS) system
CLOSPO_RS10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSPO_RS10450	COG1263	PTS System
CLOSPO_RS10895	COG0187	DNA topoisomerase II activity
CLOSPO_RS11625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLOSPO_RS12430	COG0606	chelatase, subunit chli
CLOSPO_RS12580	COG1968	undecaprenyl-diphosphatase activity
CLOSPO_RS12590	COG1482	cell wall glycoprotein biosynthetic process
CLOSPO_RS12595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLOSPO_RS12600	COG3442	glutamine amidotransferase
CLOSPO_RS12650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOSPO_RS12655	COG0840	transmembrane signaling receptor activity
CLOSPO_RS12660	COG0705	Rhomboid family
CLOSPO_RS12660	COG0457	Tetratricopeptide repeat
CLOSPO_RS12685	COG0629	single-stranded DNA binding
CLOSPO_RS12705	COG0531	amino acid
CLOSPO_RS12710	COG0531	amino acid
CLOSPO_RS12720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOSPO_RS12730	COG0573	inorganic phosphate transmembrane transporter activity
CLOSPO_RS12735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLOSPO_RS12750	COG2247	cell wall binding repeat
CLOSPO_RS12750	COG2385	sporulation resulting in formation of a cellular spore
CLOSPO_RS12780	COG1477	protein flavinylation
CLOSPO_RS12800	COG2878	Part of a membrane complex involved in electron transport
CLOSPO_RS12800	COG1245	4Fe-4S binding domain
CLOSPO_RS12805	COG4657	Part of a membrane complex involved in electron transport
CLOSPO_RS12810	COG4660	Part of a membrane complex involved in electron transport
CLOSPO_RS12815	COG4659	FMN binding
CLOSPO_RS12820	COG4658	electron transport chain
CLOSPO_RS12825	COG4656	Part of a membrane complex involved in electron transport
CLOSPO_RS12830	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLOSPO_RS12835	COG5002	protein histidine kinase activity
CLOSPO_RS12855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOSPO_RS12885	COG0398	Pfam SNARE associated Golgi protein
CLOSPO_RS12890	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLOSPO_RS12900	COG5002	protein histidine kinase activity
CLOSPO_RS12900	COG3850	Histidine kinase
CLOSPO_RS12905	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS12920	COG2409	Drug exporters of the RND superfamily
CLOSPO_RS12925	COG0671	phosphoesterase, PA-phosphatase related
CLOSPO_RS12955	COG0006	proline dipeptidase activity
CLOSPO_RS12960	COG0531	amino acid
CLOSPO_RS12965	COG3800	Transcriptional regulator
CLOSPO_RS12965	COG1396	sequence-specific DNA binding
CLOSPO_RS12970	COG0037	tRNA processing
CLOSPO_RS12975	COG5002	protein histidine kinase activity
CLOSPO_RS12995	COG5002	protein histidine kinase activity
CLOSPO_RS13010	COG4251	negative regulation of phosphorylation
CLOSPO_RS13010	COG3706	GGDEF domain
CLOSPO_RS13010	COG2203	Gaf domain
CLOSPO_RS13010	COG5001	Diguanylate cyclase
CLOSPO_RS13050	COG1346	cytolysis
CLOSPO_RS13070	COG0577	efflux transmembrane transporter activity
CLOSPO_RS13075	COG1136	(ABC) transporter
CLOSPO_RS13080	COG1968	undecaprenyl-diphosphatase activity
CLOSPO_RS13085	COG2205	protein histidine kinase activity
CLOSPO_RS13090	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS13110	COG1120	ATPase activity
CLOSPO_RS13115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSPO_RS13130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLOSPO_RS13135	COG2246	polysaccharide biosynthetic process
CLOSPO_RS13140	COG0463	Glycosyl transferase, family 2
CLOSPO_RS13145	COG2205	protein histidine kinase activity
CLOSPO_RS13145	COG2770	Histidine kinase
CLOSPO_RS13150	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS13160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOSPO_RS13170	COG0129	dihydroxy-acid dehydratase activity
CLOSPO_RS13175	COG2190	(PTS) system
CLOSPO_RS13185	COG1263	PTS System
CLOSPO_RS13185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSPO_RS13190	COG1737	Transcriptional regulator
CLOSPO_RS13195	COG0840	transmembrane signaling receptor activity
CLOSPO_RS13195	COG5278	phosphoserine phosphatase activity
CLOSPO_RS13200	COG2910	NAD(P)H-binding
CLOSPO_RS13205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CLOSPO_RS13210	COG1959	2 iron, 2 sulfur cluster binding
CLOSPO_RS13220	COG1278	Cold shock
CLOSPO_RS13235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSPO_RS13235	COG2190	(PTS) system
CLOSPO_RS13235	COG1263	PTS System
CLOSPO_RS13240	COG1486	melibiose metabolic process
CLOSPO_RS13245	COG1263	PTS System
CLOSPO_RS13245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSPO_RS13250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLOSPO_RS13255	COG0577	efflux transmembrane transporter activity
CLOSPO_RS13260	COG1136	(ABC) transporter
CLOSPO_RS13265	COG5002	protein histidine kinase activity
CLOSPO_RS13270	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS13275	COG2190	(PTS) system
CLOSPO_RS13290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSPO_RS13290	COG1263	PTS System
CLOSPO_RS13295	COG1486	melibiose metabolic process
CLOSPO_RS13300	COG0277	FAD linked oxidase domain protein
CLOSPO_RS13320	COG2205	protein histidine kinase activity
CLOSPO_RS13325	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS13330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLOSPO_RS13335	COG0785	Cytochrome C biogenesis protein
CLOSPO_RS13345	COG2176	DNA-directed DNA polymerase activity
CLOSPO_RS13350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLOSPO_RS13370	COG0833	amino acid
CLOSPO_RS13375	COG5002	protein histidine kinase activity
CLOSPO_RS13385	COG3963	phosphatidate phosphatase activity
CLOSPO_RS13400	COG0596	Alpha beta hydrolase
CLOSPO_RS13410	COG1136	(ABC) transporter
CLOSPO_RS13415	COG2205	protein histidine kinase activity
CLOSPO_RS13425	COG0662	Cupin 2, conserved barrel domain protein
CLOSPO_RS13430	COG2205	protein histidine kinase activity
CLOSPO_RS13445	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS13455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOSPO_RS13545	COG0557	exoribonuclease II activity
CLOSPO_RS13555	COG0148	phosphopyruvate hydratase activity
CLOSPO_RS13575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLOSPO_RS13585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLOSPO_RS13595	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOSPO_RS13600	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOSPO_RS13605	COG3845	ABC transporter
CLOSPO_RS13610	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOSPO_RS13615	COG1307	EDD domain protein, DegV family
CLOSPO_RS13620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLOSPO_RS13625	COG1533	DNA photolyase activity
CLOSPO_RS13630	COG2720	vancomycin resistance protein
CLOSPO_RS13635	COG2720	vancomycin resistance protein
CLOSPO_RS13640	COG1363	Peptidase, m42
CLOSPO_RS13645	COG1073	alpha beta
CLOSPO_RS13655	COG0281	malic enzyme
CLOSPO_RS13660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLOSPO_RS13670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLOSPO_RS13675	COG1045	serine acetyltransferase
CLOSPO_RS13680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOSPO_RS13695	COG1032	radical SAM domain protein
CLOSPO_RS13705	COG1597	lipid kinase activity
CLOSPO_RS13710	COG0517	IMP dehydrogenase activity
CLOSPO_RS13715	COG1183	phosphatidylcholine synthase activity
CLOSPO_RS13725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOSPO_RS13730	COG2323	membrane
CLOSPO_RS13740	COG0191	fructose-bisphosphate aldolase activity
CLOSPO_RS13760	COG0484	heat shock protein binding
CLOSPO_RS13775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLOSPO_RS13790	COG2357	RelA SpoT domain protein
CLOSPO_RS13800	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSPO_RS13825	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLOSPO_RS13830	COG2183	response to ionizing radiation
CLOSPO_RS13865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOSPO_RS13900	COG0037	tRNA processing
CLOSPO_RS13915	COG1609	Transcriptional regulator
CLOSPO_RS13925	COG2385	sporulation resulting in formation of a cellular spore
CLOSPO_RS13950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLOSPO_RS13975	COG0356	it plays a direct role in the translocation of protons across the membrane
CLOSPO_RS13985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOSPO_RS13990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOSPO_RS14005	COG0698	ribose 5-phosphate isomerase
CLOSPO_RS14010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLOSPO_RS14015	COG0009	L-threonylcarbamoyladenylate synthase
CLOSPO_RS14040	COG3872	metal-dependent enzyme
CLOSPO_RS14045	COG1435	thymidine kinase activity
CLOSPO_RS14055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLOSPO_RS14065	COG0504	CTP synthase activity
CLOSPO_RS14085	COG2959	enzyme of heme biosynthesis
CLOSPO_RS14090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOSPO_RS14110	COG0697	spore germination
CLOSPO_RS14120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLOSPO_RS14125	COG0189	ligase activity
CLOSPO_RS14125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLOSPO_RS14130	COG4242	Belongs to the peptidase S51 family
CLOSPO_RS14145	COG4466	Protein conserved in bacteria
CLOSPO_RS14200	COG1691	(AIR) carboxylase
CLOSPO_RS14205	COG1606	tRNA processing
CLOSPO_RS14210	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLOSPO_RS14215	COG0662	Cupin 2, conserved barrel domain protein
CLOSPO_RS14215	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CLOSPO_RS14220	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CLOSPO_RS14230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLOSPO_RS14235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOSPO_RS14260	COG0602	queuosine metabolic process
CLOSPO_RS14265	COG1328	CTP reductase activity
CLOSPO_RS14270	COG1285	pathogenesis
CLOSPO_RS14275	COG3706	GGDEF domain
CLOSPO_RS14285	COG1141	Ferredoxin
CLOSPO_RS14295	COG0577	efflux transmembrane transporter activity
CLOSPO_RS14300	COG1136	(ABC) transporter
CLOSPO_RS14335	COG3584	3D domain protein
CLOSPO_RS14335	COG3583	domain protein
CLOSPO_RS14340	COG0084	hydrolase, TatD family'
CLOSPO_RS14350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOSPO_RS14350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOSPO_RS14360	COG1573	uracil-dna glycosylase
CLOSPO_RS14365	COG0534	Mate efflux family protein
CLOSPO_RS14370	COG0700	Nucleoside recognition
CLOSPO_RS14375	COG2715	membrane protein required for spore maturation
CLOSPO_RS14385	COG0726	polysaccharide deacetylase
CLOSPO_RS14410	COG2002	toxin-antitoxin pair type II binding
CLOSPO_RS14415	COG0791	NLP P60 protein
CLOSPO_RS14420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLOSPO_RS14425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLOSPO_RS14440	COG1774	PSP1 C-terminal conserved region
CLOSPO_RS14450	COG3870	Protein conserved in bacteria
CLOSPO_RS14460	COG1982	Orn Lys Arg decarboxylase major
CLOSPO_RS14485	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLOSPO_RS14515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOSPO_RS14520	COG0187	DNA topoisomerase II activity
CLOSPO_RS14540	COG0592	DNA-directed DNA polymerase activity
CLOSPO_RS14570	COG1847	R3H domain protein
CLOSPO_RS14590	COG1475	DNA binding
CLOSPO_RS14595	COG1192	Involved in chromosome partitioning
CLOSPO_RS14600	COG1475	DNA binding
CLOSPO_RS14620	COG0628	permease
CLOSPO_RS14635	COG0668	transmembrane transport
CLOSPO_RS14645	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLOSPO_RS14650	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLOSPO_RS14680	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLOSPO_RS14690	COG0470	DNA polymerase III
CLOSPO_RS14690	COG1067	ATP-dependent peptidase activity
CLOSPO_RS14695	COG0305	Participates in initiation and elongation during chromosome replication
CLOSPO_RS14700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOSPO_RS14730	COG2081	HI0933 family
CLOSPO_RS14810	COG0739	heme binding
CLOSPO_RS14830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOSPO_RS14840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLOSPO_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSPO_RS14850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLOSPO_RS14855	COG0511	ligase activity, forming carbon-carbon bonds
CLOSPO_RS14865	COG0439	Biotin carboxylase
CLOSPO_RS14870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLOSPO_RS14875	COG0825	malonyl-CoA metabolic process
CLOSPO_RS14885	COG0583	DNA-binding transcription factor activity
CLOSPO_RS14890	COG1404	Belongs to the peptidase S8 family
CLOSPO_RS14895	COG0583	DNA-binding transcription factor activity
CLOSPO_RS14910	COG0613	PHP domain protein
CLOSPO_RS14915	COG0438	transferase activity, transferring glycosyl groups
CLOSPO_RS14925	COG1160	GTP binding
CLOSPO_RS14935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOSPO_RS14945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLOSPO_RS14950	COG1328	CTP reductase activity
CLOSPO_RS14955	COG4656	Part of a membrane complex involved in electron transport
CLOSPO_RS14960	COG5275	peptidyl-tyrosine sulfation
CLOSPO_RS14960	COG0252	asparaginase activity
CLOSPO_RS14970	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLOSPO_RS14975	COG5275	peptidyl-tyrosine sulfation
CLOSPO_RS14975	COG0252	asparaginase activity
CLOSPO_RS14980	COG0252	asparaginase activity
CLOSPO_RS14980	COG5275	peptidyl-tyrosine sulfation
CLOSPO_RS14990	COG0024	Methionine aminopeptidase
CLOSPO_RS15000	COG1309	transcriptional regulator
CLOSPO_RS15010	COG2814	Major facilitator Superfamily
CLOSPO_RS15030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLOSPO_RS15045	COG0174	glutamine synthetase
CLOSPO_RS15055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLOSPO_RS15065	COG1396	sequence-specific DNA binding
CLOSPO_RS15065	COG3800	Transcriptional regulator
CLOSPO_RS15070	COG0840	transmembrane signaling receptor activity
CLOSPO_RS15080	COG3949	Membrane
CLOSPO_RS15090	COG1242	4 iron, 4 sulfur cluster binding
CLOSPO_RS15095	COG2045	Belongs to the ComB family
CLOSPO_RS15105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLOSPO_RS15130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOSPO_RS15150	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS15155	COG5002	protein histidine kinase activity
CLOSPO_RS15160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLOSPO_RS15170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLOSPO_RS15180	COG2002	toxin-antitoxin pair type II binding
CLOSPO_RS15185	COG2244	polysaccharide biosynthetic process
CLOSPO_RS15190	COG3956	TIGRFAM MazG family protein
CLOSPO_RS15200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLOSPO_RS15220	COG1098	S1 RNA binding domain
CLOSPO_RS15260	COG2208	phosphoserine phosphatase activity
CLOSPO_RS15270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLOSPO_RS15275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOSPO_RS15290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLOSPO_RS15310	COG0423	glycine-tRNA ligase activity
CLOSPO_RS15420	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOSPO_RS15430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOSPO_RS15435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOSPO_RS15440	COG0473	3-isopropylmalate dehydrogenase activity
CLOSPO_RS15445	COG1126	abc transporter atp-binding protein
CLOSPO_RS15450	COG1757	Na H antiporter
CLOSPO_RS15455	COG2155	Conserved Protein
CLOSPO_RS15515	COG0840	transmembrane signaling receptor activity
CLOSPO_RS15520	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOSPO_RS15560	COG0765	amino acid transport
CLOSPO_RS15565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOSPO_RS15570	COG2226	methyltransferase
CLOSPO_RS15575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CLOSPO_RS15590	COG0352	thiamine-phosphate diphosphorylase activity
CLOSPO_RS15590	COG0351	phosphomethylpyrimidine kinase
CLOSPO_RS15645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOSPO_RS15655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLOSPO_RS15675	COG2226	methyltransferase
CLOSPO_RS15680	COG3655	Transcriptional regulator
CLOSPO_RS15690	COG0420	3'-5' exonuclease activity
CLOSPO_RS15695	COG0419	ATPase involved in DNA repair
CLOSPO_RS15705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOSPO_RS15710	COG0640	Transcriptional regulator
CLOSPO_RS15715	COG2217	Heavy metal translocating P-type atpase
CLOSPO_RS15740	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLOSPO_RS15745	COG5434	Belongs to the glycosyl hydrolase 28 family
CLOSPO_RS15745	COG4632	Exopolysaccharide biosynthesis protein
CLOSPO_RS15785	COG1131	(ABC) transporter
CLOSPO_RS15790	COG1668	transmembrane transport
CLOSPO_RS15800	COG1994	Peptidase M50
CLOSPO_RS15810	COG2197	response regulator
CLOSPO_RS15815	COG1131	(ABC) transporter
CLOSPO_RS15825	COG0842	Transport permease protein
CLOSPO_RS15855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLOSPO_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
CLOSPO_RS15865	COG2205	protein histidine kinase activity
CLOSPO_RS15865	COG0784	Response regulator, receiver
CLOSPO_RS15875	COG2267	carboxylic ester hydrolase activity
CLOSPO_RS15880	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS15890	COG0840	transmembrane signaling receptor activity
CLOSPO_RS15895	COG2204	response regulator
CLOSPO_RS15900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLOSPO_RS15905	COG1199	ATP-dependent helicase activity
CLOSPO_RS15910	COG0534	Mate efflux family protein
CLOSPO_RS15930	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CLOSPO_RS15940	COG2703	oxygen carrier activity
CLOSPO_RS15975	COG1522	sequence-specific DNA binding
CLOSPO_RS15985	COG0531	amino acid
CLOSPO_RS15990	COG0531	amino acid
CLOSPO_RS15995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CLOSPO_RS16000	COG0658	competence protein
CLOSPO_RS16000	COG2333	competence protein COMEC
CLOSPO_RS16015	COG2059	Chromate
CLOSPO_RS16020	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOSPO_RS16030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLOSPO_RS16030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOSPO_RS16050	COG0006	proline dipeptidase activity
CLOSPO_RS16065	COG0242	peptide deformylase activity
CLOSPO_RS16080	COG1073	alpha beta
CLOSPO_RS16090	COG1966	Carbon starvation protein
CLOSPO_RS16105	COG0488	(ABC) transporter
CLOSPO_RS16125	COG0653	protein targeting
CLOSPO_RS16130	COG1725	Transcriptional regulator
CLOSPO_RS16135	COG1131	(ABC) transporter
CLOSPO_RS16145	COG0840	transmembrane signaling receptor activity
CLOSPO_RS16150	COG3842	ATPase activity
CLOSPO_RS16160	COG1177	transmembrane transport
CLOSPO_RS16170	COG1301	dicarboxylic acid transport
CLOSPO_RS16175	COG0454	-acetyltransferase
CLOSPO_RS16185	COG1357	PFAM Pentapeptide repeats (8 copies)
CLOSPO_RS16190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOSPO_RS16190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOSPO_RS16215	COG3279	Response regulator of the LytR AlgR family
CLOSPO_RS16255	COG1132	(ABC) transporter
CLOSPO_RS16275	COG1136	(ABC) transporter
CLOSPO_RS16295	COG2252	PERMEase
CLOSPO_RS16305	COG1307	EDD domain protein, DegV family
CLOSPO_RS16320	COG1368	sulfuric ester hydrolase activity
CLOSPO_RS16330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLOSPO_RS16350	COG1131	(ABC) transporter
CLOSPO_RS16400	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS16405	COG2205	protein histidine kinase activity
CLOSPO_RS16410	COG1876	peptidase activity
CLOSPO_RS16420	COG5002	protein histidine kinase activity
CLOSPO_RS16440	COG0784	Response regulator, receiver
CLOSPO_RS16445	COG5002	protein histidine kinase activity
CLOSPO_RS16450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLOSPO_RS16455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLOSPO_RS16490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOSPO_RS16495	COG0662	Cupin 2, conserved barrel domain protein
CLOSPO_RS16495	COG2207	Transcriptional regulator
CLOSPO_RS16510	COG0346	lactoylglutathione lyase activity
CLOSPO_RS16515	COG1193	negative regulation of DNA recombination
CLOSPO_RS16535	COG2832	Protein of unknown function (DUF454)
CLOSPO_RS16555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOSPO_RS16580	COG0513	Belongs to the DEAD box helicase family
CLOSPO_RS16595	COG2814	Major facilitator Superfamily
CLOSPO_RS16610	COG5002	protein histidine kinase activity
CLOSPO_RS16625	COG4632	Exopolysaccharide biosynthesis protein
CLOSPO_RS16625	COG5434	Belongs to the glycosyl hydrolase 28 family
CLOSPO_RS16635	COG1876	peptidase activity
CLOSPO_RS16645	COG4608	Belongs to the ABC transporter superfamily
CLOSPO_RS16650	COG0444	Belongs to the ABC transporter superfamily
CLOSPO_RS16655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOSPO_RS16660	COG0601	transmembrane transport
CLOSPO_RS16665	COG0747	negative chemotaxis
CLOSPO_RS16680	COG0583	DNA-binding transcription factor activity
CLOSPO_RS16685	COG2949	membrane
CLOSPO_RS16700	COG2176	DNA-directed DNA polymerase activity
CLOSPO_RS16705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLOSPO_RS16725	COG3711	transcriptional antiterminator
CLOSPO_RS16730	COG2190	(PTS) system
CLOSPO_RS16730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLOSPO_RS16730	COG1263	PTS System
CLOSPO_RS16735	COG0613	PHP domain protein
CLOSPO_RS16740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOSPO_RS16760	COG0519	Catalyzes the synthesis of GMP from XMP
CLOSPO_RS16770	COG0786	glutamate:sodium symporter activity
CLOSPO_RS16800	COG4120	Belongs to the binding-protein-dependent transport system permease family
CLOSPO_RS16805	COG1122	ATPase activity
CLOSPO_RS16825	COG2112	serine threonine protein kinase
CLOSPO_RS16840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLOSPO_RS16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSPO_RS16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSPO_RS16880	COG1120	ATPase activity
CLOSPO_RS16885	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CLOSPO_RS16890	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CLOSPO_RS16910	COG0110	maltose O-acetyltransferase activity
CLOSPO_RS16915	COG3620	sequence-specific DNA binding
CLOSPO_RS16955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOSPO_RS16960	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOSPO_RS16965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOSPO_RS16970	COG0095	Lipoate-protein ligase
CLOSPO_RS16980	COG4185	zeta toxin
CLOSPO_RS16985	COG0697	spore germination
CLOSPO_RS16990	COG1476	TRANSCRIPTIONal
CLOSPO_RS17005	COG2207	Transcriptional regulator
CLOSPO_RS17015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOSPO_RS17040	COG0488	(ABC) transporter
CLOSPO_RS17045	COG2378	regulation of single-species biofilm formation
CLOSPO_RS17060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOSPO_RS17065	COG1854	S-ribosylhomocysteine lyase activity
CLOSPO_RS17070	COG0626	cystathionine gamma-synthase activity
CLOSPO_RS17075	COG2226	methyltransferase
CLOSPO_RS17095	COG2226	methyltransferase
CLOSPO_RS17100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOSPO_RS17135	COG1396	sequence-specific DNA binding
CLOSPO_RS17195	COG0798	PFAM Bile acid sodium symporter
CLOSPO_RS17220	COG2217	Heavy metal translocating P-type atpase
CLOSPO_RS17235	COG1132	(ABC) transporter
CLOSPO_RS17260	COG0351	phosphomethylpyrimidine kinase
CLOSPO_RS17260	COG0352	thiamine-phosphate diphosphorylase activity
CLOSPO_RS17275	COG1131	(ABC) transporter
CLOSPO_RS17285	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS17300	COG2207	Transcriptional regulator
CLOSPO_RS17300	COG3708	Transcriptional regulator
CLOSPO_RS17305	COG2205	protein histidine kinase activity
CLOSPO_RS17325	COG1136	(ABC) transporter
CLOSPO_RS17345	COG3850	Histidine kinase
CLOSPO_RS17345	COG5002	protein histidine kinase activity
CLOSPO_RS17380	COG0375	protein maturation
CLOSPO_RS17415	COG1203	CRISPR-associated helicase, Cas3
CLOSPO_RS17430	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CLOSPO_RS17435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLOSPO_RS17465	COG1228	amidohydrolase
CLOSPO_RS17470	COG1114	Component of the transport system for branched-chain amino acids
CLOSPO_RS17475	COG1114	Component of the transport system for branched-chain amino acids
CLOSPO_RS17480	COG0840	transmembrane signaling receptor activity
CLOSPO_RS17490	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOSPO_RS17495	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOSPO_RS17500	COG0406	alpha-ribazole phosphatase activity
CLOSPO_RS17505	COG2720	vancomycin resistance protein
CLOSPO_RS17540	COG0720	synthase
CLOSPO_RS17545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLOSPO_RS17555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLOSPO_RS17555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLOSPO_RS17560	COG0789	Transcriptional regulator
CLOSPO_RS17565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOSPO_RS17580	COG2207	Transcriptional regulator
CLOSPO_RS17580	COG3708	Transcriptional regulator
CLOSPO_RS17600	COG1131	(ABC) transporter
CLOSPO_RS17605	COG3620	sequence-specific DNA binding
CLOSPO_RS17645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOSPO_RS17650	COG0384	phenazine biosynthesis protein PhzF
CLOSPO_RS17665	COG1741	Belongs to the pirin family
CLOSPO_RS17670	COG1733	regulation of RNA biosynthetic process
CLOSPO_RS17675	COG0778	Nitroreductase
CLOSPO_RS17685	COG1611	Belongs to the LOG family
CLOSPO_RS17695	COG0583	DNA-binding transcription factor activity
CLOSPO_RS17700	COG0519	Catalyzes the synthesis of GMP from XMP
CLOSPO_RS17710	COG2378	regulation of single-species biofilm formation
CLOSPO_RS17725	COG0789	Transcriptional regulator
CLOSPO_RS17735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOSPO_RS17740	COG0778	Nitroreductase
CLOSPO_RS17795	COG0789	Transcriptional regulator
CLOSPO_RS17820	COG2207	Transcriptional regulator
CLOSPO_RS17820	COG3708	Transcriptional regulator
CLOSPO_RS17845	COG1376	ErfK ybiS ycfS ynhG family protein
CLOSPO_RS17885	COG2423	ornithine cyclodeaminase activity
CLOSPO_RS17895	COG1136	(ABC) transporter
CLOSPO_RS17895	COG0577	efflux transmembrane transporter activity
CLOSPO_RS17905	COG5002	protein histidine kinase activity
CLOSPO_RS17910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLOSPO_RS17925	COG1268	BioY protein
CLOSPO_RS17935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLOSPO_RS17940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLOSPO_RS17960	COG0789	Transcriptional regulator
CLOSPO_RS17980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CLOSPO_RS17985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOSPO_RS18020	COG0113	porphobilinogen synthase activity
CLOSPO_RS18060	COG0454	-acetyltransferase
CLOSPO_RS18065	COG3177	Filamentation induced by cAMP protein fic
CLOSPO_RS18080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CLOSPO_RS18180	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLOSPO_RS18190	COG2116	formate transmembrane transporter activity
CLOSPO_RS18240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOSPO_RS18260	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS18265	COG2205	protein histidine kinase activity
CLOSPO_RS18270	COG1120	ATPase activity
CLOSPO_RS18275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSPO_RS18285	COG2376	Dihydroxyacetone kinase
CLOSPO_RS18295	COG2207	Transcriptional regulator
CLOSPO_RS18295	COG0662	Cupin 2, conserved barrel domain protein
CLOSPO_RS18310	COG0454	-acetyltransferase
CLOSPO_RS18330	COG0656	L-ascorbic acid biosynthetic process
CLOSPO_RS18395	COG0514	ATP-dependent DNA helicase (RecQ)
CLOSPO_RS18400	COG1592	Rubrerythrin
CLOSPO_RS18400	COG1773	rubredoxin
CLOSPO_RS18405	COG0840	transmembrane signaling receptor activity
CLOSPO_RS18415	COG0622	Phosphoesterase
CLOSPO_RS18420	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS18440	COG0602	queuosine metabolic process
CLOSPO_RS18455	COG1620	l-lactate permease
CLOSPO_RS18460	COG3875	lactate racemase activity
CLOSPO_RS18465	COG2086	electron transfer activity
CLOSPO_RS18470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOSPO_RS18475	COG0277	FAD linked oxidase domain protein
CLOSPO_RS18480	COG3279	Response regulator of the LytR AlgR family
CLOSPO_RS18510	COG0436	Aminotransferase
CLOSPO_RS18520	COG1846	Transcriptional regulator
CLOSPO_RS18525	COG0789	Transcriptional regulator
CLOSPO_RS18525	COG4978	Transcriptional regulator
CLOSPO_RS18535	COG0017	Asparaginyl-tRNA synthetase
CLOSPO_RS18560	COG1011	Hydrolase
CLOSPO_RS18575	COG0583	DNA-binding transcription factor activity
CLOSPO_RS18585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOSPO_RS18585	COG1918	ferrous iron import across plasma membrane
CLOSPO_RS18605	COG1876	peptidase activity
CLOSPO_RS18620	COG5002	protein histidine kinase activity
CLOSPO_RS18630	COG2124	cytochrome p450
CLOSPO_RS18635	COG2323	membrane
CLOSPO_RS18640	COG2323	membrane
CLOSPO_RS18655	COG2132	Multicopper oxidase
CLOSPO_RS18675	COG0745	RESPONSE REGULATOR receiver
CLOSPO_RS18680	COG5002	protein histidine kinase activity
CLOSPO_RS18685	COG4977	sequence-specific DNA binding
CLOSPO_RS18685	COG1917	Cupin 2, conserved barrel domain protein
CLOSPO_RS18690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOSPO_RS18695	COG4605	iron ion homeostasis
CLOSPO_RS18700	COG4604	ABC transporter, ATP-binding protein
CLOSPO_RS18705	COG4607	ABC-type enterochelin transport system periplasmic component
CLOSPO_RS18710	COG2207	Transcriptional regulator
CLOSPO_RS18725	COG1129	ABC transporter
CLOSPO_RS18730	COG1132	(ABC) transporter
CLOSPO_RS18735	COG1132	(ABC) transporter
CLOSPO_RS18745	COG3279	Response regulator of the LytR AlgR family
CLOSPO_RS18765	COG1940	carbohydrate kinase activity
CLOSPO_RS18780	COG0463	Glycosyl transferase, family 2
CLOSPO_RS18780	COG0457	Tetratricopeptide repeat
CLOSPO_RS18800	COG0463	Glycosyl transferase, family 2
CLOSPO_RS18815	COG1331	Highly conserved protein containing a thioredoxin domain
CLOSPO_RS18820	COG4129	membrane
CLOSPO_RS18840	COG0488	(ABC) transporter
CLOSPO_RS18865	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOSPO_RS18875	COG2271	Major facilitator Superfamily
CLOSPO_RS18890	COG0436	Aminotransferase
CLOSPO_RS18925	COG3979	chitinase
CLOSPO_RS18930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOSPO_RS18935	COG2011	ABC-type metal ion transport system permease component
CLOSPO_RS18940	COG1464	Belongs to the NlpA lipoprotein family
CLOSPO_RS18945	COG1464	Belongs to the NlpA lipoprotein family
CLOSPO_RS18950	COG1473	amidohydrolase
CLOSPO_RS18965	COG2186	Transcriptional regulator
CLOSPO_RS18970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOSPO_RS18990	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLOSPO_RS19000	COG0617	tRNA 3'-terminal CCA addition
CLOSPO_RS19005	COG1012	belongs to the aldehyde dehydrogenase family
CLOSPO_RS19010	COG1115	amino acid carrier protein
CLOSPO_RS19070	COG2337	Toxic component of a toxin-antitoxin (TA) module