locus-tag	class	description
CLOST_RS00195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLOST_RS00200	COG0592	DNA-directed DNA polymerase activity
CLOST_RS00210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOST_RS00215	COG0187	DNA topoisomerase II activity
CLOST_RS00220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOST_RS00225	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CLOST_RS00240	COG1366	Belongs to the anti-sigma-factor antagonist family
CLOST_RS00245	COG2172	sigma factor antagonist activity
CLOST_RS00250	COG1191	sigma factor activity
CLOST_RS00275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLOST_RS00285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLOST_RS00295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLOST_RS00300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLOST_RS00305	COG1309	transcriptional regulator
CLOST_RS00315	COG4187	Peptidase family M20/M25/M40
CLOST_RS00330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CLOST_RS00345	COG1125	glycine betaine transport
CLOST_RS00345	COG0517	IMP dehydrogenase activity
CLOST_RS00355	COG0840	transmembrane signaling receptor activity
CLOST_RS00370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLOST_RS00375	COG1174	glycine betaine transport
CLOST_RS00385	COG1174	glycine betaine transport
CLOST_RS00395	COG0010	Belongs to the arginase family
CLOST_RS00400	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLOST_RS00405	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLOST_RS00410	COG1982	Orn Lys Arg decarboxylase major
CLOST_RS00415	COG3457	Alanine racemase
CLOST_RS00425	COG1785	Belongs to the alkaline phosphatase family
CLOST_RS00430	COG1615	UPF0182 protein
CLOST_RS00440	COG1592	Rubrerythrin
CLOST_RS00445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLOST_RS00465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLOST_RS00495	COG2226	methyltransferase
CLOST_RS00540	COG0590	tRNA wobble adenosine to inosine editing
CLOST_RS00550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOST_RS00560	COG3842	ATPase activity
CLOST_RS00565	COG0523	cobalamin synthesis protein
CLOST_RS00580	COG5012	cobalamin binding
CLOST_RS00585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLOST_RS00610	COG0444	Belongs to the ABC transporter superfamily
CLOST_RS00615	COG4608	Belongs to the ABC transporter superfamily
CLOST_RS00620	COG0747	negative chemotaxis
CLOST_RS00630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOST_RS00635	COG2011	ABC-type metal ion transport system permease component
CLOST_RS00640	COG1464	Belongs to the NlpA lipoprotein family
CLOST_RS00655	COG1132	(ABC) transporter
CLOST_RS00660	COG0840	transmembrane signaling receptor activity
CLOST_RS00665	COG0488	(ABC) transporter
CLOST_RS00670	COG0826	peptidase U32
CLOST_RS00675	COG0840	transmembrane signaling receptor activity
CLOST_RS00680	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CLOST_RS00695	COG0590	tRNA wobble adenosine to inosine editing
CLOST_RS00715	COG0475	glutathione-regulated potassium exporter activity
CLOST_RS00715	COG0589	response to stress
CLOST_RS00720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOST_RS00725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLOST_RS00730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLOST_RS00750	COG1741	Belongs to the pirin family
CLOST_RS00775	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CLOST_RS00790	COG2239	Acts as a magnesium transporter
CLOST_RS00810	COG0393	Putative heavy-metal-binding
CLOST_RS00820	COG0784	Response regulator, receiver
CLOST_RS00820	COG3437	response regulator, receiver
CLOST_RS00830	COG0488	(ABC) transporter
CLOST_RS00845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLOST_RS00850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLOST_RS00855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLOST_RS00860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLOST_RS00870	COG0137	argininosuccinate synthase activity
CLOST_RS00880	COG2827	Endonuclease containing a URI domain
CLOST_RS00895	COG0840	transmembrane signaling receptor activity
CLOST_RS00910	COG0671	phosphoesterase, PA-phosphatase related
CLOST_RS00925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOST_RS00930	COG0482	sulfurtransferase activity
CLOST_RS00945	COG0783	Belongs to the Dps family
CLOST_RS00950	COG0346	lactoylglutathione lyase activity
CLOST_RS00960	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CLOST_RS00965	COG0542	response to heat
CLOST_RS00970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLOST_RS00980	COG4956	integral membrane protein (PIN domain superfamily)
CLOST_RS01000	COG0438	transferase activity, transferring glycosyl groups
CLOST_RS01020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLOST_RS01040	COG1193	negative regulation of DNA recombination
CLOST_RS01055	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLOST_RS01070	COG1288	antiporter activity
CLOST_RS01085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLOST_RS01095	COG1459	type II secretion system
CLOST_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
CLOST_RS01145	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLOST_RS01155	COG3246	L-lysine catabolic process to acetate
CLOST_RS01165	COG3829	transcription factor binding
CLOST_RS01165	COG3290	protein histidine kinase activity
CLOST_RS01185	COG0280	phosphate acetyltransferase
CLOST_RS01210	COG1373	ATPase (AAA superfamily
CLOST_RS01220	COG3876	Protein conserved in bacteria
CLOST_RS01230	COG1136	(ABC) transporter
CLOST_RS01250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOST_RS01265	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLOST_RS01270	COG1408	metallophosphoesterase
CLOST_RS01275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLOST_RS01280	COG1704	LemA family
CLOST_RS01285	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLOST_RS01290	COG1074	ATP-dependent DNA helicase activity
CLOST_RS01295	COG1307	EDD domain protein, DegV family
CLOST_RS01315	COG4948	Mandelate Racemase Muconate Lactonizing
CLOST_RS01320	COG1151	hydroxylamine reductase activity
CLOST_RS01325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLOST_RS01325	COG3153	acetyltransferase
CLOST_RS01335	COG0840	transmembrane signaling receptor activity
CLOST_RS01340	COG1316	TRANSCRIPTIONal
CLOST_RS01350	COG2814	Major facilitator Superfamily
CLOST_RS01365	COG0745	RESPONSE REGULATOR receiver
CLOST_RS01370	COG5002	protein histidine kinase activity
CLOST_RS01400	COG4303	Ethanolamine ammonia lyase large subunit
CLOST_RS01405	COG4302	ethanolamine ammonia-lyase activity
CLOST_RS01420	COG1454	alcohol dehydrogenase
CLOST_RS01420	COG1012	belongs to the aldehyde dehydrogenase family
CLOST_RS01435	COG4869	propanediol catabolic process
CLOST_RS01445	COG3192	ethanolamine utilization protein
CLOST_RS01460	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOST_RS01465	COG4656	Part of a membrane complex involved in electron transport
CLOST_RS01470	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOST_RS01475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLOST_RS01480	COG4535	Mg2 and Co2 transporter CorC
CLOST_RS01510	COG1122	ATPase activity
CLOST_RS01540	COG0543	2 iron, 2 sulfur cluster binding
CLOST_RS01545	COG0167	dihydroorotate dehydrogenase activity
CLOST_RS01550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLOST_RS01565	COG0737	Belongs to the 5'-nucleotidase family
CLOST_RS01570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CLOST_RS01580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOST_RS01585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLOST_RS01590	COG0459	protein refolding
CLOST_RS01595	COG1691	(AIR) carboxylase
CLOST_RS01600	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLOST_RS01605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOST_RS01610	COG1132	(ABC) transporter
CLOST_RS01620	COG0534	Mate efflux family protein
CLOST_RS01635	COG0516	GMP reductase activity
CLOST_RS01635	COG0517	IMP dehydrogenase activity
CLOST_RS01640	COG0519	Catalyzes the synthesis of GMP from XMP
CLOST_RS01640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLOST_RS01655	COG0582	viral genome integration into host DNA
CLOST_RS01680	COG3843	relaxase mobilization nuclease domain protein
CLOST_RS01730	COG0534	Mate efflux family protein
CLOST_RS01745	COG1704	LemA family
CLOST_RS01755	COG0456	acetyltransferase
CLOST_RS01760	COG1192	Involved in chromosome partitioning
CLOST_RS01785	COG2321	neutral zinc metallopeptidase
CLOST_RS01790	COG0693	protein deglycase activity
CLOST_RS01800	COG0840	transmembrane signaling receptor activity
CLOST_RS01800	COG5278	phosphoserine phosphatase activity
CLOST_RS01805	COG2252	PERMEase
CLOST_RS01810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLOST_RS01815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLOST_RS01820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLOST_RS01825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLOST_RS01830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLOST_RS01835	COG0138	bifunctional purine biosynthesis protein purh
CLOST_RS01840	COG0151	Belongs to the GarS family
CLOST_RS01845	COG0840	transmembrane signaling receptor activity
CLOST_RS01850	COG3956	TIGRFAM MazG family protein
CLOST_RS01855	COG0776	regulation of translation
CLOST_RS01860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLOST_RS01870	COG0248	Ppx GppA phosphatase
CLOST_RS01890	COG4196	transglutaminase domain protein
CLOST_RS01895	COG3409	Peptidoglycan-binding domain 1 protein
CLOST_RS01895	COG0793	Belongs to the peptidase S41A family
CLOST_RS01935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLOST_RS01940	COG0367	asparagine synthase
CLOST_RS01950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLOST_RS01960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOST_RS01965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLOST_RS01975	COG2089	acid synthase
CLOST_RS01980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOST_RS01985	COG1083	cytidylyl-transferase
CLOST_RS01990	COG0728	peptidoglycan biosynthetic process
CLOST_RS02015	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOST_RS02020	COG3845	ABC transporter
CLOST_RS02025	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOST_RS02040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOST_RS02055	COG0443	Heat shock 70 kDa protein
CLOST_RS02065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLOST_RS02110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLOST_RS02115	COG0531	amino acid
CLOST_RS02125	COG0140	phosphoribosyl-ATP diphosphatase activity
CLOST_RS02130	COG5001	Diguanylate cyclase
CLOST_RS02165	COG0840	transmembrane signaling receptor activity
CLOST_RS02175	COG3237	CsbD-like
CLOST_RS02180	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLOST_RS02190	COG0307	riboflavin synthase, alpha
CLOST_RS02195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOST_RS02195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOST_RS02200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLOST_RS02205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOST_RS02210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOST_RS02220	COG0473	3-isopropylmalate dehydrogenase activity
CLOST_RS02225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLOST_RS02250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOST_RS02260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLOST_RS02265	COG0509	glycine decarboxylation via glycine cleavage system
CLOST_RS02270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOST_RS02275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOST_RS02280	COG0436	Aminotransferase
CLOST_RS02285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOST_RS02290	COG2234	aminopeptidase activity
CLOST_RS02300	COG0019	diaminopimelate decarboxylase activity
CLOST_RS02345	COG0110	maltose O-acetyltransferase activity
CLOST_RS02350	COG0463	Glycosyl transferase, family 2
CLOST_RS02390	COG1136	(ABC) transporter
CLOST_RS02395	COG0577	efflux transmembrane transporter activity
CLOST_RS02410	COG1566	PFAM secretion protein HlyD family protein
CLOST_RS02430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLOST_RS02435	COG1361	Conserved repeat domain
CLOST_RS02440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLOST_RS02445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLOST_RS02450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOST_RS02450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOST_RS02455	COG0084	hydrolase, TatD family'
CLOST_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLOST_RS02475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLOST_RS02480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOST_RS02485	COG2088	sporulation resulting in formation of a cellular spore
CLOST_RS02490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLOST_RS02500	COG0193	aminoacyl-tRNA hydrolase activity
CLOST_RS02505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLOST_RS02510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLOST_RS02515	COG0315	cyclic pyranopterin monophosphate synthase activity
CLOST_RS02520	COG2244	polysaccharide biosynthetic process
CLOST_RS02690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLOST_RS02700	COG3426	butyrate kinase activity
CLOST_RS02705	COG0280	phosphate acetyltransferase
CLOST_RS02725	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOST_RS02740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOST_RS02750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOST_RS02785	COG5592	hemerythrin HHE cation binding domain
CLOST_RS02790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLOST_RS02800	COG0556	nucleotide-excision repair
CLOST_RS02865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLOST_RS02870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLOST_RS02875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOST_RS02880	COG0131	Imidazoleglycerol-phosphate dehydratase
CLOST_RS02885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLOST_RS02905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLOST_RS02905	COG0140	phosphoribosyl-ATP diphosphatase activity
CLOST_RS02915	COG0681	Belongs to the peptidase S26 family
CLOST_RS02920	COG0390	transport system, permease component
CLOST_RS02925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOST_RS02940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLOST_RS02945	COG0251	oxidation-reduction process
CLOST_RS02950	COG0673	inositol 2-dehydrogenase activity
CLOST_RS02955	COG1879	ABC-type sugar transport system periplasmic component
CLOST_RS02960	COG2972	Histidine kinase
CLOST_RS02970	COG4213	ABC transporter substrate-binding protein
CLOST_RS02975	COG4213	ABC transporter substrate-binding protein
CLOST_RS02985	COG4214	carbohydrate transport
CLOST_RS02995	COG1811	Na channel or pump
CLOST_RS03000	COG0322	excinuclease ABC activity
CLOST_RS03010	COG1940	carbohydrate kinase activity
CLOST_RS03030	COG4667	esterase of the alpha-beta hydrolase superfamily
CLOST_RS03040	COG0210	DNA helicase
CLOST_RS03045	COG1362	aminopeptidase activity
CLOST_RS03095	COG2268	Band 7 protein
CLOST_RS03100	COG2217	Heavy metal translocating P-type atpase
CLOST_RS03110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLOST_RS03115	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOST_RS03130	COG1597	lipid kinase activity
CLOST_RS03135	COG3706	GGDEF domain
CLOST_RS03140	COG1741	Belongs to the pirin family
CLOST_RS03145	COG0534	Mate efflux family protein
CLOST_RS03160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLOST_RS03165	COG2890	protein-(glutamine-N5) methyltransferase activity
CLOST_RS03170	COG0601	transmembrane transport
CLOST_RS03175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOST_RS03180	COG0444	Belongs to the ABC transporter superfamily
CLOST_RS03185	COG4608	Belongs to the ABC transporter superfamily
CLOST_RS03190	COG4166	transmembrane transport
CLOST_RS03195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLOST_RS03210	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLOST_RS03215	COG0740	serine-type endopeptidase activity
CLOST_RS03220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLOST_RS03235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLOST_RS03240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLOST_RS03255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOST_RS03265	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLOST_RS03270	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLOST_RS03275	COG0166	Belongs to the GPI family
CLOST_RS03285	COG1653	transport
CLOST_RS03290	COG1301	dicarboxylic acid transport
CLOST_RS03295	COG1121	(ABC) transporter
CLOST_RS03300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLOST_RS03310	COG0840	transmembrane signaling receptor activity
CLOST_RS03315	COG0840	transmembrane signaling receptor activity
CLOST_RS03320	COG0840	transmembrane signaling receptor activity
CLOST_RS03330	COG0573	inorganic phosphate transmembrane transporter activity
CLOST_RS03335	COG0581	inorganic phosphate transmembrane transporter activity
CLOST_RS03340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOST_RS03345	COG0704	Plays a role in the regulation of phosphate uptake
CLOST_RS03350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOST_RS03375	COG0525	valine-tRNA ligase activity
CLOST_RS03380	COG0285	dihydrofolate synthase activity
CLOST_RS03395	COG2226	methyltransferase
CLOST_RS03405	COG1473	amidohydrolase
CLOST_RS03440	COG0675	Transposase, IS605 OrfB family
CLOST_RS03445	COG2226	methyltransferase
CLOST_RS03450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLOST_RS03460	COG2390	Transcriptional regulator
CLOST_RS03470	COG0126	phosphoglycerate kinase activity
CLOST_RS03475	COG0149	triose-phosphate isomerase activity
CLOST_RS03485	COG0148	phosphopyruvate hydratase activity
CLOST_RS03500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOST_RS03505	COG0287	Prephenate dehydrogenase
CLOST_RS03510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLOST_RS03515	COG1605	Chorismate mutase
CLOST_RS03515	COG0077	Prephenate dehydratase
CLOST_RS03525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLOST_RS03530	COG0557	exoribonuclease II activity
CLOST_RS03540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLOST_RS03550	COG2199	diguanylate cyclase activity
CLOST_RS03550	COG2203	Gaf domain
CLOST_RS03560	COG2203	Gaf domain
CLOST_RS03560	COG3706	GGDEF domain
CLOST_RS03560	COG5001	Diguanylate cyclase
CLOST_RS03560	COG4251	negative regulation of phosphorylation
CLOST_RS03570	COG3829	transcription factor binding
CLOST_RS03570	COG3290	protein histidine kinase activity
CLOST_RS03585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLOST_RS03600	COG1307	EDD domain protein, DegV family
CLOST_RS03610	COG3706	GGDEF domain
CLOST_RS03620	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_RS03625	COG1349	DNA-binding transcription factor activity
CLOST_RS03630	COG0235	Class ii aldolase
CLOST_RS03660	COG4869	propanediol catabolic process
CLOST_RS03665	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOST_RS03675	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOST_RS03695	COG1129	ABC transporter
CLOST_RS03700	COG4214	carbohydrate transport
CLOST_RS03710	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLOST_RS03730	COG0598	Magnesium transport protein CorA
CLOST_RS03765	COG1032	radical SAM domain protein
CLOST_RS03775	COG2226	methyltransferase
CLOST_RS03810	COG1342	Belongs to the UPF0251 family
CLOST_RS03825	COG0312	modulator of DNA gyrase
CLOST_RS03840	COG2207	Transcriptional regulator
CLOST_RS03840	COG3708	Transcriptional regulator
CLOST_RS03855	COG4895	conserved protein (DUF2196)
CLOST_RS03875	COG2357	RelA SpoT domain protein
CLOST_RS03880	COG0813	purine-nucleoside phosphorylase activity
CLOST_RS03885	COG0322	excinuclease ABC activity
CLOST_RS03890	COG2161	toxin-antitoxin pair type II binding
CLOST_RS03980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOST_RS03995	COG0420	3'-5' exonuclease activity
CLOST_RS04000	COG0419	ATPase involved in DNA repair
CLOST_RS04015	COG3118	belongs to the thioredoxin family
CLOST_RS04020	COG3706	GGDEF domain
CLOST_RS04065	COG0840	transmembrane signaling receptor activity
CLOST_RS04075	COG0701	Predicted permease
CLOST_RS04080	COG0640	Transcriptional regulator
CLOST_RS04100	COG0798	PFAM Bile acid sodium symporter
CLOST_RS04105	COG2203	Gaf domain
CLOST_RS04105	COG3706	GGDEF domain
CLOST_RS04105	COG5001	Diguanylate cyclase
CLOST_RS04105	COG4251	negative regulation of phosphorylation
CLOST_RS04110	COG1609	Transcriptional regulator
CLOST_RS04115	COG1129	ABC transporter
CLOST_RS04120	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOST_RS04130	COG1063	alcohol dehydrogenase
CLOST_RS04135	COG1070	Carbohydrate kinase
CLOST_RS04145	COG4134	Bacterial extracellular solute-binding protein
CLOST_RS04150	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOST_RS04160	COG3842	ATPase activity
CLOST_RS04175	COG0398	Pfam SNARE associated Golgi protein
CLOST_RS04195	COG1136	(ABC) transporter
CLOST_RS04210	COG1132	(ABC) transporter
CLOST_RS04215	COG1132	(ABC) transporter
CLOST_RS04265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOST_RS04270	COG0569	domain protein
CLOST_RS04270	COG2985	domain, Protein
CLOST_RS04275	COG0006	proline dipeptidase activity
CLOST_RS04280	COG1228	amidohydrolase
CLOST_RS04340	COG1982	Orn Lys Arg decarboxylase major
CLOST_RS04360	COG2414	aldehyde ferredoxin oxidoreductase
CLOST_RS04365	COG3383	formate dehydrogenase (NAD+) activity
CLOST_RS04370	COG3383	formate dehydrogenase (NAD+) activity
CLOST_RS04375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_RS04380	COG3300	MHYT domain
CLOST_RS04380	COG5001	Diguanylate cyclase
CLOST_RS04390	COG0275	rRNA processing
CLOST_RS04405	COG0303	'Molybdopterin
CLOST_RS04415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_RS04425	COG1910	domain protein
CLOST_RS04440	COG0653	protein targeting
CLOST_RS04460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOST_RS04475	COG0714	Associated with various cellular activities
CLOST_RS04485	COG1305	Transglutaminase-like
CLOST_RS04500	COG1078	dGTPase activity
CLOST_RS04505	COG1459	type II secretion system
CLOST_RS04545	COG2309	aminopeptidase activity
CLOST_RS04550	COG1278	Cold shock
CLOST_RS04555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLOST_RS04565	COG1217	gtp-binding protein TYPA
CLOST_RS04570	COG0745	RESPONSE REGULATOR receiver
CLOST_RS04605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLOST_RS04615	COG0601	transmembrane transport
CLOST_RS04620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOST_RS04630	COG4608	Belongs to the ABC transporter superfamily
CLOST_RS04635	COG3437	response regulator, receiver
CLOST_RS04670	COG0511	ligase activity, forming carbon-carbon bonds
CLOST_RS04675	COG0439	Biotin carboxylase
CLOST_RS04680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLOST_RS04690	COG1846	Transcriptional regulator
CLOST_RS04695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOST_RS04705	COG2070	2-Nitropropane dioxygenase
CLOST_RS04710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLOST_RS04720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLOST_RS04725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLOST_RS04730	COG0460	homoserine dehydrogenase
CLOST_RS04745	COG0248	Ppx GppA phosphatase
CLOST_RS04755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLOST_RS04775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOST_RS04785	COG0564	pseudouridine synthase activity
CLOST_RS04790	COG2119	membrane
CLOST_RS04800	COG1968	undecaprenyl-diphosphatase activity
CLOST_RS04805	COG1242	4 iron, 4 sulfur cluster binding
CLOST_RS04825	COG2357	RelA SpoT domain protein
CLOST_RS04835	COG0205	6-phosphofructokinase activity
CLOST_RS04840	COG2313	pseudouridylate synthase activity
CLOST_RS04845	COG2223	nitrite transmembrane transporter activity
CLOST_RS04850	COG0789	Transcriptional regulator
CLOST_RS04855	COG2235	arginine
CLOST_RS04860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLOST_RS04865	COG0549	Belongs to the carbamate kinase family
CLOST_RS04880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLOST_RS04885	COG1802	Transcriptional regulator
CLOST_RS04890	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOST_RS04900	COG0037	tRNA processing
CLOST_RS04905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOST_RS04910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_RS04910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_RS04915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_RS04915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_RS04925	COG0346	lactoylglutathione lyase activity
CLOST_RS04930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLOST_RS04940	COG4770	biotin carboxylase activity
CLOST_RS04945	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CLOST_RS04955	COG3191	aminopeptidase activity
CLOST_RS04965	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLOST_RS04975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLOST_RS04980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLOST_RS04995	COG1492	cobalamin metabolic process
CLOST_RS05000	COG1328	CTP reductase activity
CLOST_RS05035	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_RS05045	COG1288	antiporter activity
CLOST_RS05050	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_RS05060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOST_RS05065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOST_RS05070	COG0297	glycogen (starch) synthase activity
CLOST_RS05075	COG0058	SHG alpha-glucan phosphorylase activity
CLOST_RS05105	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLOST_RS05110	COG1846	Transcriptional regulator
CLOST_RS05115	COG0386	Belongs to the glutathione peroxidase family
CLOST_RS05130	COG1797	cobyrinic acid a,c-diamide synthase activity
CLOST_RS05145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOST_RS05160	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLOST_RS05200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLOST_RS05205	COG1648	precorrin-2 dehydrogenase activity
CLOST_RS05205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLOST_RS05210	COG0181	hydroxymethylbilane synthase activity
CLOST_RS05220	COG0113	porphobilinogen synthase activity
CLOST_RS05225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLOST_RS05245	COG3845	ABC transporter
CLOST_RS05250	COG1609	Transcriptional regulator
CLOST_RS05255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOST_RS05285	COG0697	spore germination
CLOST_RS05290	COG0037	tRNA processing
CLOST_RS05305	COG0745	RESPONSE REGULATOR receiver
CLOST_RS05310	COG2205	protein histidine kinase activity
CLOST_RS05320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLOST_RS05330	COG1051	belongs to the nudix hydrolase family
CLOST_RS05345	COG2364	Membrane
CLOST_RS05350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLOST_RS05360	COG3177	Filamentation induced by cAMP protein fic
CLOST_RS05390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOST_RS05415	COG0124	histidyl-tRNA synthetase
CLOST_RS05425	COG1396	sequence-specific DNA binding
CLOST_RS05430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOST_RS05450	COG5001	Diguanylate cyclase
CLOST_RS05465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOST_RS05470	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLOST_RS05505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLOST_RS05560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOST_RS05575	COG1966	Carbon starvation protein
CLOST_RS05585	COG3279	Response regulator of the LytR AlgR family
CLOST_RS05590	COG3275	phosphorelay sensor kinase activity
CLOST_RS05600	COG2364	Membrane
CLOST_RS05605	COG3290	protein histidine kinase activity
CLOST_RS05605	COG3829	transcription factor binding
CLOST_RS05615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLOST_RS05620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLOST_RS05630	COG2339	peptidase activity
CLOST_RS05635	COG0483	inositol monophosphate 1-phosphatase activity
CLOST_RS05645	COG1659	Linocin_M18 bacteriocin protein
CLOST_RS05650	COG3384	dioxygenase
CLOST_RS05665	COG0681	Belongs to the peptidase S26 family
CLOST_RS05675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOST_RS05690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLOST_RS05695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLOST_RS05700	COG2720	vancomycin resistance protein
CLOST_RS05710	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLOST_RS05715	COG0406	alpha-ribazole phosphatase activity
CLOST_RS05720	COG0561	phosphatase activity
CLOST_RS05725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLOST_RS05730	COG1307	EDD domain protein, DegV family
CLOST_RS05745	COG3118	belongs to the thioredoxin family
CLOST_RS05765	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLOST_RS05780	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOST_RS05790	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLOST_RS05795	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLOST_RS05805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLOST_RS05825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOST_RS05835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLOST_RS05840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLOST_RS05845	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLOST_RS05850	COG1024	Enoyl-CoA hydratase
CLOST_RS05860	COG0183	Belongs to the thiolase family
CLOST_RS05865	COG1960	acyl-CoA dehydrogenase activity
CLOST_RS05870	COG2086	electron transfer activity
CLOST_RS05875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOST_RS05885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLOST_RS05890	COG0569	domain protein
CLOST_RS05895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOST_RS05900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLOST_RS05905	COG0072	phenylalanine-tRNA ligase activity
CLOST_RS05905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOST_RS05915	COG0826	peptidase U32
CLOST_RS05920	COG1193	negative regulation of DNA recombination
CLOST_RS05935	COG0018	arginyl-trna synthetase
CLOST_RS05955	COG1032	radical SAM domain protein
CLOST_RS05965	COG0280	phosphate acetyltransferase
CLOST_RS05980	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOST_RS05990	COG1151	hydroxylamine reductase activity
CLOST_RS06000	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CLOST_RS06005	COG3404	Formiminotransferase-cyclodeaminase
CLOST_RS06020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOST_RS06050	COG0509	glycine decarboxylation via glycine cleavage system
CLOST_RS06085	COG0210	DNA helicase
CLOST_RS06130	COG0651	ATP synthesis coupled electron transport
CLOST_RS06140	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CLOST_RS06150	COG0191	fructose-bisphosphate aldolase activity
CLOST_RS06155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CLOST_RS06155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOST_RS06160	COG1187	pseudouridine synthase activity
CLOST_RS06170	COG3586	endonuclease activity
CLOST_RS06180	COG4086	secreted protein
CLOST_RS06185	COG1671	Belongs to the UPF0178 family
CLOST_RS06190	COG2188	Transcriptional regulator
CLOST_RS06195	COG3842	ATPase activity
CLOST_RS06205	COG1177	transmembrane transport
CLOST_RS06210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CLOST_RS06225	COG2270	Major facilitator Superfamily
CLOST_RS06260	COG3842	ATPase activity
CLOST_RS06275	COG0531	amino acid
CLOST_RS06290	COG0436	Aminotransferase
CLOST_RS06315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOST_RS06320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLOST_RS06325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLOST_RS06335	COG1923	regulation of RNA biosynthetic process
CLOST_RS06345	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLOST_RS06355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLOST_RS06365	COG4974	Belongs to the 'phage' integrase family
CLOST_RS06370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLOST_RS06395	COG0473	3-isopropylmalate dehydrogenase activity
CLOST_RS06400	COG0372	Belongs to the citrate synthase family
CLOST_RS06405	COG4974	Belongs to the 'phage' integrase family
CLOST_RS06415	COG0582	viral genome integration into host DNA
CLOST_RS06455	COG0514	ATP-dependent DNA helicase (RecQ)
CLOST_RS06510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOST_RS06580	COG3404	Formiminotransferase-cyclodeaminase
CLOST_RS06585	COG1228	amidohydrolase
CLOST_RS06590	COG2431	L-lysine efflux transmembrane transporter activity
CLOST_RS06600	COG3457	Alanine racemase
CLOST_RS06610	COG5012	cobalamin binding
CLOST_RS06620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOST_RS06630	COG3804	dihydrodipicolinate reductase
CLOST_RS06635	COG3829	transcription factor binding
CLOST_RS06640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLOST_RS06660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLOST_RS06665	COG0124	histidyl-tRNA synthetase
CLOST_RS06670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOST_RS06675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOST_RS06680	COG1490	D-aminoacyl-tRNA deacylase activity
CLOST_RS06685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLOST_RS06690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOST_RS06695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLOST_RS06695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLOST_RS06710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLOST_RS06715	COG1862	Preprotein translocase
CLOST_RS06720	COG0343	queuine tRNA-ribosyltransferase activity
CLOST_RS06725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLOST_RS06730	COG2247	cell wall binding repeat
CLOST_RS06730	COG2385	sporulation resulting in formation of a cellular spore
CLOST_RS06735	COG2255	four-way junction helicase activity
CLOST_RS06740	COG0632	four-way junction helicase activity
CLOST_RS06745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLOST_RS06750	COG0534	Mate efflux family protein
CLOST_RS06755	COG1846	Transcriptional regulator
CLOST_RS06760	COG4946	Tricorn protease homolog
CLOST_RS06760	COG1506	peptidase
CLOST_RS06760	COG0823	Involved in the tonB-independent uptake of proteins
CLOST_RS06765	COG0217	transcriptional regulatory protein
CLOST_RS06770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOST_RS06780	COG1739	Uncharacterized protein family UPF0029
CLOST_RS06790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLOST_RS06800	COG0826	peptidase U32
CLOST_RS06805	COG4122	O-methyltransferase activity
CLOST_RS06810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLOST_RS06840	COG0463	Glycosyl transferase, family 2
CLOST_RS06855	COG0497	DNA recombination
CLOST_RS06860	COG1438	arginine binding
CLOST_RS06865	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLOST_RS06870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLOST_RS06875	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CLOST_RS06895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLOST_RS06900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOST_RS06905	COG1302	Protein conserved in bacteria
CLOST_RS06910	COG0416	fatty acid biosynthetic process
CLOST_RS06915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLOST_RS06920	COG1399	metal-binding, possibly nucleic acid-binding protein
CLOST_RS06925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLOST_RS06940	COG0745	RESPONSE REGULATOR receiver
CLOST_RS06960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLOST_RS06965	COG1596	polysaccharide export
CLOST_RS06965	COG1555	photosystem II stabilization
CLOST_RS06970	COG1686	Belongs to the peptidase S11 family
CLOST_RS06980	COG1760	l-serine dehydratase
CLOST_RS06985	COG1760	l-serine dehydratase
CLOST_RS06990	COG0799	negative regulation of ribosome biogenesis
CLOST_RS06995	COG1316	TRANSCRIPTIONal
CLOST_RS07000	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLOST_RS07005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLOST_RS07015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLOST_RS07020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLOST_RS07030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLOST_RS07035	COG1530	ribonuclease E activity
CLOST_RS07050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_RS07055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOST_RS07060	COG1193	negative regulation of DNA recombination
CLOST_RS07070	COG1509	lysine 2,3-aminomutase activity
CLOST_RS07075	COG0604	alcohol dehydrogenase
CLOST_RS07080	COG3246	L-lysine catabolic process to acetate
CLOST_RS07085	COG1607	acyl-coa hydrolase
CLOST_RS07090	COG1803	Methylglyoxal synthase
CLOST_RS07095	COG0772	Belongs to the SEDS family
CLOST_RS07100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLOST_RS07110	COG0850	regulation of cytokinetic process
CLOST_RS07115	COG0768	penicillin binding
CLOST_RS07130	COG2003	Belongs to the UPF0758 family
CLOST_RS07135	COG0424	maF-like protein
CLOST_RS07140	COG2878	Part of a membrane complex involved in electron transport
CLOST_RS07140	COG1245	4Fe-4S binding domain
CLOST_RS07145	COG4657	Part of a membrane complex involved in electron transport
CLOST_RS07150	COG4660	Part of a membrane complex involved in electron transport
CLOST_RS07155	COG4659	FMN binding
CLOST_RS07160	COG4658	electron transport chain
CLOST_RS07165	COG4656	Part of a membrane complex involved in electron transport
CLOST_RS07170	COG0791	NLP P60 protein
CLOST_RS07185	COG0741	lytic transglycosylase activity
CLOST_RS07190	COG0237	dephospho-CoA kinase activity
CLOST_RS07195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOST_RS07195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOST_RS07230	COG0527	aspartate kinase activity
CLOST_RS07240	COG1477	protein flavinylation
CLOST_RS07260	COG1252	NADH dehydrogenase
CLOST_RS07270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLOST_RS07275	COG0129	dihydroxy-acid dehydratase activity
CLOST_RS07280	COG0028	Belongs to the TPP enzyme family
CLOST_RS07285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLOST_RS07290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLOST_RS07305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOST_RS07320	COG0463	Glycosyl transferase, family 2
CLOST_RS07325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOST_RS07335	COG0583	DNA-binding transcription factor activity
CLOST_RS07340	COG2391	methyltransferase activity
CLOST_RS07350	COG2391	methyltransferase activity
CLOST_RS07360	COG0243	molybdopterin cofactor binding
CLOST_RS07375	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_RS07380	COG1950	PFAM Membrane protein of
CLOST_RS07385	COG0301	tRNA thio-modification
CLOST_RS07390	COG1104	cysteine desulfurase activity
CLOST_RS07405	COG1924	4 iron, 4 sulfur cluster binding
CLOST_RS07410	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLOST_RS07415	COG2081	HI0933 family
CLOST_RS07425	COG0287	Prephenate dehydrogenase
CLOST_RS07425	COG1605	Chorismate mutase
CLOST_RS07430	COG0849	cell division
CLOST_RS07435	COG0583	DNA-binding transcription factor activity
CLOST_RS07440	COG1362	aminopeptidase activity
CLOST_RS07475	COG1773	rubredoxin
CLOST_RS07480	COG2359	stage V sporulation protein S
CLOST_RS07485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLOST_RS07490	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOST_RS07490	COG0539	negative regulation of cytoplasmic translation
CLOST_RS07505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLOST_RS07525	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOST_RS07530	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOST_RS07530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOST_RS07550	COG1187	pseudouridine synthase activity
CLOST_RS07555	COG1396	sequence-specific DNA binding
CLOST_RS07560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLOST_RS07565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLOST_RS07570	COG1994	Peptidase M50
CLOST_RS07575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLOST_RS07585	COG0735	belongs to the Fur family
CLOST_RS07600	COG0667	Aldo Keto reductase
CLOST_RS07610	COG4472	Bacterial protein of unknown function (DUF965)
CLOST_RS07615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOST_RS07630	COG1959	2 iron, 2 sulfur cluster binding
CLOST_RS07635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLOST_RS07640	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CLOST_RS07645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOST_RS07650	COG0758	DNA mediated transformation
CLOST_RS07655	COG0606	chelatase, subunit chli
CLOST_RS07730	COG5632	N-Acetylmuramoyl-L-alanine amidase
CLOST_RS07730	COG3409	Peptidoglycan-binding domain 1 protein
CLOST_RS07810	COG3728	DNA packaging
CLOST_RS07810	COG5484	DNA packaging
CLOST_RS07845	COG0629	single-stranded DNA binding
CLOST_RS07875	COG3935	DnaD domain protein
CLOST_RS07890	COG1196	nuclear chromosome segregation
CLOST_RS07920	COG3561	AntA/AntB antirepressor
CLOST_RS07965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLOST_RS07970	COG0606	chelatase, subunit chli
CLOST_RS07975	COG0792	nuclease activity
CLOST_RS07990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLOST_RS08000	COG0335	large ribosomal subunit rRNA binding
CLOST_RS08005	COG0336	Belongs to the RNA methyltransferase TrmD family
CLOST_RS08010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLOST_RS08015	COG1837	Belongs to the UPF0109 family
CLOST_RS08020	COG0228	four-way junction DNA binding
CLOST_RS08025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLOST_RS08030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CLOST_RS08035	COG0552	protein localization to endoplasmic reticulum
CLOST_RS08050	COG0571	ribonuclease III activity
CLOST_RS08060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLOST_RS08065	COG0835	chemotaxis
CLOST_RS08065	COG0784	Response regulator, receiver
CLOST_RS08070	COG0756	dUTP diphosphatase activity
CLOST_RS08075	COG1115	amino acid carrier protein
CLOST_RS08080	COG1794	racemase activity, acting on amino acids and derivatives
CLOST_RS08100	COG0710	3-dehydroquinate dehydratase activity
CLOST_RS08105	COG1970	mechanosensitive ion channel activity
CLOST_RS08115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOST_RS08130	COG5002	protein histidine kinase activity
CLOST_RS08135	COG0745	RESPONSE REGULATOR receiver
CLOST_RS08150	COG1126	abc transporter atp-binding protein
CLOST_RS08155	COG0765	amino acid transport
CLOST_RS08160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOST_RS08165	COG0572	uridine kinase
CLOST_RS08180	COG1131	(ABC) transporter
CLOST_RS08185	COG1725	Transcriptional regulator
CLOST_RS08190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOST_RS08195	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOST_RS08215	COG0697	spore germination
CLOST_RS08225	COG0156	8-amino-7-oxononanoate synthase activity
CLOST_RS08240	COG2201	protein-glutamate methylesterase activity
CLOST_RS08255	COG0346	lactoylglutathione lyase activity
CLOST_RS08290	COG1131	(ABC) transporter
CLOST_RS08300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLOST_RS08320	COG0202	RNA polymerase activity
CLOST_RS08340	COG0733	neurotransmitter:sodium symporter activity
CLOST_RS08355	COG0205	6-phosphofructokinase activity
CLOST_RS08365	COG1464	Belongs to the NlpA lipoprotein family
CLOST_RS08370	COG2011	ABC-type metal ion transport system permease component
CLOST_RS08375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOST_RS08380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOST_RS08385	COG1481	regulation of sporulation
CLOST_RS08395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLOST_RS08400	COG1660	Displays ATPase and GTPase activities
CLOST_RS08410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLOST_RS08425	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLOST_RS08435	COG1242	4 iron, 4 sulfur cluster binding
CLOST_RS08440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOST_RS08450	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CLOST_RS08455	COG0310	cobalt ion transport
CLOST_RS08460	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLOST_RS08460	COG3443	Belongs to the bacterial solute-binding protein 9 family
CLOST_RS08465	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CLOST_RS08505	COG1418	mRNA catabolic process
CLOST_RS08510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLOST_RS08515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOST_RS08520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOST_RS08525	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CLOST_RS08530	COG1674	ftsk spoiiie
CLOST_RS08535	COG1185	polyribonucleotide nucleotidyltransferase activity
CLOST_RS08540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLOST_RS08545	COG0196	riboflavin kinase activity
CLOST_RS08550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLOST_RS08565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLOST_RS08570	COG1358	cellular component organization or biogenesis
CLOST_RS08580	COG0195	Participates in both transcription termination and antitermination
CLOST_RS08585	COG0779	Required for maturation of 30S ribosomal subunits
CLOST_RS08600	COG0750	zinc metalloprotease
CLOST_RS08605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLOST_RS08610	COG4589	Belongs to the CDS family
CLOST_RS08625	COG0233	cytoplasmic translational termination
CLOST_RS08630	COG0528	UMP kinase activity
CLOST_RS08635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLOST_RS08640	COG0052	Belongs to the universal ribosomal protein uS2 family
CLOST_RS08660	COG1191	sigma factor activity
CLOST_RS08670	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLOST_RS08675	COG1776	CheC inhibitor of MCP methylation
CLOST_RS08680	COG0835	chemotaxis
CLOST_RS08685	COG0643	Histidine kinase
CLOST_RS08685	COG2198	Histidine kinase
CLOST_RS08690	COG2201	protein-glutamate methylesterase activity
CLOST_RS08705	COG1419	protein localization to endoplasmic reticulum
CLOST_RS08710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOST_RS08715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOST_RS08720	COG1684	flagellar biosynthetic protein fliR
CLOST_RS08725	COG1987	bacterial-type flagellum assembly
CLOST_RS08730	COG1338	Plays a role in the flagellum-specific transport system
CLOST_RS08740	COG2201	protein-glutamate methylesterase activity
CLOST_RS08745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOST_RS08745	COG1776	CheC inhibitor of MCP methylation
CLOST_RS08750	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOST_RS08785	COG3144	bacterial-type flagellum assembly
CLOST_RS08800	COG1157	protein secretion by the type III secretion system
CLOST_RS08810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOST_RS08820	COG1677	Flagellar hook-basal body complex protein FliE
CLOST_RS08825	COG1558	bacterial-type flagellum-dependent cell motility
CLOST_RS08835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CLOST_RS08840	COG1177	transmembrane transport
CLOST_RS08845	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOST_RS08850	COG3842	ATPase activity
CLOST_RS08860	COG0116	Belongs to the methyltransferase superfamily
CLOST_RS08865	COG1606	tRNA processing
CLOST_RS08880	COG2384	SAM-dependent methyltransferase
CLOST_RS08885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOST_RS08890	COG0358	DNA primase activity
CLOST_RS08895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOST_RS08900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLOST_RS08910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLOST_RS08915	COG0302	gtp cyclohydrolase
CLOST_RS08925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLOST_RS08930	COG0512	Glutamine amidotransferase of anthranilate synthase
CLOST_RS08940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLOST_RS08945	COG0574	Belongs to the PEP-utilizing enzyme family
CLOST_RS08945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOST_RS08950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLOST_RS08955	COG0517	IMP dehydrogenase activity
CLOST_RS08960	COG0751	glycine-tRNA ligase activity
CLOST_RS08965	COG0752	glycyl-tRNA synthetase alpha subunit
CLOST_RS08975	COG1381	Involved in DNA repair and RecF pathway recombination
CLOST_RS08980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLOST_RS08985	COG0295	cytidine deaminase activity
CLOST_RS08990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLOST_RS08995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLOST_RS09000	COG1702	phosphate starvation-inducible protein PhoH
CLOST_RS09005	COG2033	superoxide reductase activity
CLOST_RS09010	COG1098	S1 RNA binding domain
CLOST_RS09025	COG4864	UPF0365 protein
CLOST_RS09030	COG1030	water channel activity
CLOST_RS09040	COG1610	YqeY-like protein
CLOST_RS09045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLOST_RS09050	COG0537	adenosine 5'-monophosphoramidase activity
CLOST_RS09055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOST_RS09060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLOST_RS09065	COG2264	protein methyltransferase activity
CLOST_RS09070	COG0484	heat shock protein binding
CLOST_RS09075	COG0443	Heat shock 70 kDa protein
CLOST_RS09080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLOST_RS09085	COG1420	regulation of RNA biosynthetic process
CLOST_RS09090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOST_RS09095	COG0785	Cytochrome C biogenesis protein
CLOST_RS09105	COG0157	Belongs to the NadC ModD family
CLOST_RS09115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLOST_RS09120	COG0481	GTPase activity
CLOST_RS09125	COG0268	Binds directly to 16S ribosomal RNA
CLOST_RS09135	COG0658	competence protein
CLOST_RS09135	COG2333	competence protein COMEC
CLOST_RS09170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOST_RS09175	COG1058	Belongs to the CinA family
CLOST_RS09175	COG1546	Belongs to the CinA family
CLOST_RS09180	COG2070	2-Nitropropane dioxygenase
CLOST_RS09185	COG2154	pterin-4-alpha-carbinolamine dehydratase
CLOST_RS09210	COG2732	(Barnase) inhibitor
CLOST_RS09225	COG1187	pseudouridine synthase activity
CLOST_RS09230	COG1120	ATPase activity
CLOST_RS09235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOST_RS09245	COG2171	N-acyltransferase activity
CLOST_RS09250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLOST_RS09255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOST_RS09260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLOST_RS09265	COG5001	Diguanylate cyclase
CLOST_RS09265	COG3300	MHYT domain
CLOST_RS09280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLOST_RS09290	COG1323	Belongs to the UPF0348 family
CLOST_RS09300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLOST_RS09305	COG0742	ribosomal rna small subunit methyltransferase
CLOST_RS09310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLOST_RS09315	COG1461	Dihydroxyacetone kinase
CLOST_RS09320	COG1302	Protein conserved in bacteria
CLOST_RS09325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLOST_RS09335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLOST_RS09340	COG1162	GTPase activity
CLOST_RS09345	COG2815	serine threonine protein kinase
CLOST_RS09345	COG0515	serine threonine protein kinase
CLOST_RS09350	COG0631	protein serine/threonine phosphatase activity
CLOST_RS09355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLOST_RS09360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOST_RS09360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOST_RS09365	COG2738	Putative neutral zinc metallopeptidase
CLOST_RS09375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLOST_RS09385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLOST_RS09390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLOST_RS09395	COG1758	RNA polymerase activity
CLOST_RS09400	COG0194	GDP metabolic process
CLOST_RS09405	COG2052	Domain of unknown function (DUF370)
CLOST_RS09410	COG1561	YicC-like family, N-terminal region
CLOST_RS09415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLOST_RS09425	COG1295	ribonuclease BN
CLOST_RS09445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLOST_RS09450	COG0564	pseudouridine synthase activity
CLOST_RS09455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLOST_RS09465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLOST_RS09480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLOST_RS09485	COG3599	regulation of cell shape
CLOST_RS09490	COG2302	S4 RNA-binding domain
CLOST_RS09500	COG1799	cell septum assembly
CLOST_RS09505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLOST_RS09515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLOST_RS09520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLOST_RS09525	COG1160	GTP binding
CLOST_RS09535	COG5002	protein histidine kinase activity
CLOST_RS09540	COG0745	RESPONSE REGULATOR receiver
CLOST_RS09550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLOST_RS09555	COG3856	small basic protein
CLOST_RS09560	COG3879	Bacterial protein of unknown function (DUF881)
CLOST_RS09575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOST_RS09580	COG0772	Belongs to the SEDS family
CLOST_RS09585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLOST_RS09590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOST_RS09595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLOST_RS09600	COG0768	penicillin binding
CLOST_RS09610	COG0275	rRNA processing
CLOST_RS09615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLOST_RS09620	COG0612	Peptidase, M16
CLOST_RS09630	COG0012	GTP binding
CLOST_RS09660	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_RS09665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_RS09665	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOST_RS09665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOST_RS09665	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOST_RS09670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOST_RS09675	COG4869	propanediol catabolic process
CLOST_RS09695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLOST_RS09700	COG2096	Adenosyltransferase
CLOST_RS09705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOST_RS09715	COG0697	spore germination
CLOST_RS09740	COG2197	response regulator
CLOST_RS09745	COG4585	Histidine kinase
CLOST_RS09750	COG0835	chemotaxis
CLOST_RS09755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOST_RS09770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOST_RS09775	COG0564	pseudouridine synthase activity
CLOST_RS09780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLOST_RS09785	COG0622	Phosphoesterase
CLOST_RS09800	COG4536	flavin adenine dinucleotide binding
CLOST_RS09810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLOST_RS09840	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOST_RS09845	COG0579	oxidoreductase
CLOST_RS09850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLOST_RS09855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLOST_RS09880	COG2267	carboxylic ester hydrolase activity
CLOST_RS09925	COG1733	regulation of RNA biosynthetic process
CLOST_RS09950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLOST_RS09955	COG3300	MHYT domain
CLOST_RS09955	COG5001	Diguanylate cyclase
CLOST_RS09975	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CLOST_RS09980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CLOST_RS09985	COG0133	tryptophan synthase activity
CLOST_RS09995	COG0628	permease
CLOST_RS10000	COG0542	response to heat
CLOST_RS10005	COG2313	pseudouridylate synthase activity
CLOST_RS10010	COG1522	sequence-specific DNA binding
CLOST_RS10010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOST_RS10025	COG0326	Molecular chaperone. Has ATPase activity
CLOST_RS10030	COG0159	tryptophan synthase activity
CLOST_RS10035	COG0133	tryptophan synthase activity
CLOST_RS10040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOST_RS10050	COG0134	indole-3-glycerol-phosphate synthase activity
CLOST_RS10060	COG0512	Glutamine amidotransferase of anthranilate synthase
CLOST_RS10060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLOST_RS10085	COG1959	2 iron, 2 sulfur cluster binding
CLOST_RS10100	COG1827	regulation of RNA biosynthetic process
CLOST_RS10125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLOST_RS10130	COG0352	thiamine-phosphate diphosphorylase activity
CLOST_RS10135	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLOST_RS10140	COG0351	phosphomethylpyrimidine kinase
CLOST_RS10150	COG1363	Peptidase, m42
CLOST_RS10155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOST_RS10215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOST_RS10220	COG0708	Exodeoxyribonuclease III
CLOST_RS10245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOST_RS10255	COG1011	Hydrolase
CLOST_RS10285	COG0626	cystathionine gamma-synthase activity
CLOST_RS10305	COG0495	leucyl-tRNA aminoacylation
CLOST_RS10335	COG1937	Protein conserved in bacteria
CLOST_RS10340	COG2217	Heavy metal translocating P-type atpase
CLOST_RS10345	COG3437	response regulator, receiver
CLOST_RS10350	COG2199	diguanylate cyclase activity
CLOST_RS10355	COG0659	secondary active sulfate transmembrane transporter activity
CLOST_RS10400	COG0517	IMP dehydrogenase activity
CLOST_RS10405	COG0539	negative regulation of cytoplasmic translation
CLOST_RS10420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOST_RS10430	COG2964	Protein conserved in bacteria
CLOST_RS10435	COG2116	formate transmembrane transporter activity
CLOST_RS10445	COG0095	Lipoate-protein ligase
CLOST_RS10450	COG0628	permease
CLOST_RS10455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLOST_RS10475	COG0534	Mate efflux family protein
CLOST_RS10480	COG0534	Mate efflux family protein
CLOST_RS10495	COG0793	Belongs to the peptidase S41A family
CLOST_RS10495	COG3409	Peptidoglycan-binding domain 1 protein
CLOST_RS10500	COG0739	heme binding
CLOST_RS10505	COG2177	Part of the ABC transporter FtsEX involved in
CLOST_RS10515	COG0095	Lipoate-protein ligase
CLOST_RS10520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLOST_RS10525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLOST_RS10540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLOST_RS10545	COG1122	ATPase activity
CLOST_RS10550	COG1122	ATPase activity
CLOST_RS10575	COG3901	Regulator of nitric oxide reductase transcription
CLOST_RS10575	COG0348	domain, Protein
CLOST_RS10595	COG1361	Conserved repeat domain
CLOST_RS10600	COG1067	ATP-dependent peptidase activity
CLOST_RS10605	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLOST_RS10620	COG1368	sulfuric ester hydrolase activity
CLOST_RS10630	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOST_RS10635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLOST_RS10640	COG0736	holo-[acyl-carrier-protein] synthase activity
CLOST_RS10650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLOST_RS10655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLOST_RS10660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLOST_RS10665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLOST_RS10700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOST_RS10705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOST_RS10715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLOST_RS10720	COG0698	ribose 5-phosphate isomerase
CLOST_RS10730	COG0009	L-threonylcarbamoyladenylate synthase
CLOST_RS10735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLOST_RS10740	COG2890	protein-(glutamine-N5) methyltransferase activity
CLOST_RS10745	COG3872	metal-dependent enzyme
CLOST_RS10750	COG1435	thymidine kinase activity
CLOST_RS10755	COG0254	rRNA binding
CLOST_RS10760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLOST_RS10765	COG1494	fructose-1,6-bisphosphatase
CLOST_RS10770	COG1494	fructose-1,6-bisphosphatase
CLOST_RS10775	COG1353	crispr-associated protein
CLOST_RS10775	COG0617	tRNA 3'-terminal CCA addition
CLOST_RS10780	COG2002	toxin-antitoxin pair type II binding
CLOST_RS10785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLOST_RS10790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLOST_RS10795	COG1774	PSP1 C-terminal conserved region
CLOST_RS10800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOST_RS10805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLOST_RS10810	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLOST_RS10815	COG2873	o-acetylhomoserine
CLOST_RS10820	COG0038	chloride channel
CLOST_RS10825	COG0840	transmembrane signaling receptor activity
CLOST_RS10860	COG1683	Conserved Protein
CLOST_RS10875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLOST_RS10880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLOST_RS10890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLOST_RS10895	COG1122	ATPase activity
CLOST_RS10900	COG1122	ATPase activity
CLOST_RS10915	COG0202	RNA polymerase activity
CLOST_RS10920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOST_RS10925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLOST_RS10930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLOST_RS10935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLOST_RS10940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLOST_RS10950	COG0024	Methionine aminopeptidase
CLOST_RS10955	COG0563	adenylate kinase activity
CLOST_RS10960	COG0201	protein transport
CLOST_RS10965	COG0200	Binds to the 23S rRNA
CLOST_RS10970	COG1841	ribosomal large subunit assembly
CLOST_RS10975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLOST_RS10980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLOST_RS10985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLOST_RS10990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLOST_RS10995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLOST_RS11000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLOST_RS11005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLOST_RS11010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLOST_RS11015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLOST_RS11020	COG0255	Belongs to the universal ribosomal protein uL29 family
CLOST_RS11025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLOST_RS11030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLOST_RS11035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLOST_RS11040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLOST_RS11045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLOST_RS11050	COG0089	rRNA binding
CLOST_RS11055	COG0088	Forms part of the polypeptide exit tunnel
CLOST_RS11060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLOST_RS11065	COG0051	transcription antitermination factor activity, RNA binding
CLOST_RS11095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLOST_RS11100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOST_RS11105	COG0049	tRNA binding
CLOST_RS11110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLOST_RS11115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLOST_RS11120	COG0085	RNA polymerase activity
CLOST_RS11125	COG0222	ribosome binding
CLOST_RS11130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLOST_RS11135	COG0081	regulation of translation
CLOST_RS11140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLOST_RS11145	COG0250	Participates in transcription elongation, termination and antitermination
CLOST_RS11150	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLOST_RS11155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLOST_RS11160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLOST_RS11180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOST_RS11210	COG5275	peptidyl-tyrosine sulfation
CLOST_RS11210	COG0252	asparaginase activity
CLOST_RS11215	COG5275	peptidyl-tyrosine sulfation
CLOST_RS11215	COG0252	asparaginase activity
CLOST_RS11220	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLOST_RS11225	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLOST_RS11235	COG5275	peptidyl-tyrosine sulfation
CLOST_RS11235	COG0252	asparaginase activity
CLOST_RS11240	COG4656	Part of a membrane complex involved in electron transport
CLOST_RS11250	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CLOST_RS11255	COG0442	prolyl-tRNA aminoacylation
CLOST_RS11265	COG0215	cysteine-tRNA ligase activity
CLOST_RS11270	COG1045	serine acetyltransferase
CLOST_RS11275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOST_RS11285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLOST_RS11290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLOST_RS11295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLOST_RS11305	COG4608	Belongs to the ABC transporter superfamily
CLOST_RS11310	COG0444	Belongs to the ABC transporter superfamily
CLOST_RS11315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOST_RS11320	COG0601	transmembrane transport
CLOST_RS11360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLOST_RS11365	COG5002	protein histidine kinase activity
CLOST_RS11385	COG0513	Belongs to the DEAD box helicase family
CLOST_RS11390	COG1278	Cold shock
CLOST_RS11395	COG4172	Belongs to the ABC transporter superfamily
CLOST_RS11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOST_RS11405	COG0601	transmembrane transport
CLOST_RS11415	COG0500	methyltransferase
CLOST_RS11435	COG0735	belongs to the Fur family
CLOST_RS11445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLOST_RS11495	COG0488	(ABC) transporter
CLOST_RS11505	COG0488	(ABC) transporter
CLOST_RS11510	COG0778	Nitroreductase
CLOST_RS11515	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLOST_RS11520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLOST_RS11535	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CLOST_RS11540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLOST_RS11545	COG0488	(ABC) transporter
CLOST_RS11550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLOST_RS11555	COG0456	acetyltransferase
CLOST_RS11560	COG1214	PFAM Peptidase M22, glycoprotease
CLOST_RS11565	COG0802	atpase or kinase
CLOST_RS11570	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLOST_RS11575	COG2183	response to ionizing radiation
CLOST_RS11585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOST_RS11605	COG1307	EDD domain protein, DegV family
CLOST_RS11610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLOST_RS11615	COG0653	protein targeting
CLOST_RS11620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CLOST_RS11625	COG1394	ATPase activity, coupled to movement of substances
CLOST_RS11655	COG1269	ATP hydrolysis coupled proton transport
CLOST_RS11685	COG2197	response regulator
CLOST_RS11705	COG1516	flagellar protein fliS
CLOST_RS11710	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLOST_RS11730	COG0673	inositol 2-dehydrogenase activity
CLOST_RS11755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOST_RS11760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLOST_RS11770	COG0463	Glycosyl transferase, family 2
CLOST_RS11775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOST_RS11780	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLOST_RS11785	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLOST_RS11790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOST_RS11795	COG1256	bacterial-type flagellum assembly
CLOST_RS11795	COG4786	Flagellar basal body rod
CLOST_RS11820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOST_RS11855	COG4786	Flagellar basal body rod
CLOST_RS11860	COG1077	Cell shape determining protein MreB Mrl
CLOST_RS11865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLOST_RS11880	COG5263	repeat protein
CLOST_RS11880	COG4193	domain, Protein
CLOST_RS11885	COG2239	Acts as a magnesium transporter
CLOST_RS11895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOST_RS11900	COG3681	Belongs to the UPF0597 family
CLOST_RS11905	COG2964	Protein conserved in bacteria
CLOST_RS11915	COG1595	DNA-templated transcription, initiation
CLOST_RS11920	COG3437	response regulator, receiver
CLOST_RS11920	COG0784	Response regulator, receiver
CLOST_RS11925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLOST_RS11930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLOST_RS11935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLOST_RS11940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLOST_RS12065	COG4191	Histidine kinase
CLOST_RS12065	COG0745	RESPONSE REGULATOR receiver
CLOST_RS12065	COG2205	protein histidine kinase activity
CLOST_RS12075	COG4251	negative regulation of phosphorylation
CLOST_RS12075	COG2203	Gaf domain
CLOST_RS12075	COG3706	GGDEF domain
CLOST_RS12075	COG5001	Diguanylate cyclase
CLOST_RS12080	COG1757	Na H antiporter
CLOST_RS12085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOST_RS12090	COG0628	permease
CLOST_RS12095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOST_RS12115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOST_RS12120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLOST_RS12125	COG0083	homoserine kinase activity
CLOST_RS12140	COG1268	BioY protein
CLOST_RS12145	COG0281	malic enzyme
CLOST_RS12155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLOST_RS12170	COG0789	Transcriptional regulator
CLOST_RS12195	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CLOST_RS12200	COG1879	ABC-type sugar transport system periplasmic component
CLOST_RS12205	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOST_RS12210	COG1129	ABC transporter
CLOST_RS12220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOST_RS12240	COG3706	GGDEF domain
CLOST_RS12265	COG0017	Asparaginyl-tRNA synthetase
CLOST_RS12270	COG2897	thiosulfate sulfurtransferase activity
CLOST_RS12315	COG0784	Response regulator, receiver
CLOST_RS12315	COG3437	response regulator, receiver
CLOST_RS12330	COG0840	transmembrane signaling receptor activity
CLOST_RS12345	COG1126	abc transporter atp-binding protein
CLOST_RS12365	COG1757	Na H antiporter
CLOST_RS12425	COG2824	Alkylphosphonate utilization operon protein PhnA
CLOST_RS12435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLOST_RS12440	COG0488	(ABC) transporter
CLOST_RS12460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOST_RS12465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOST_RS12470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOST_RS12475	COG1120	ATPase activity
CLOST_RS12490	COG1032	radical SAM domain protein
CLOST_RS12520	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CLOST_RS12545	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOST_RS12575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLOST_RS12580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOST_RS12600	COG1131	(ABC) transporter
CLOST_RS12605	COG0789	Transcriptional regulator
CLOST_RS12620	COG3620	sequence-specific DNA binding
CLOST_RS12630	COG0577	efflux transmembrane transporter activity
CLOST_RS12630	COG1136	(ABC) transporter
CLOST_RS12640	COG2814	Major facilitator Superfamily
CLOST_RS12645	COG1309	transcriptional regulator
CLOST_RS12665	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CLOST_RS12690	COG0514	ATP-dependent DNA helicase (RecQ)
CLOST_RS12700	COG3177	Filamentation induced by cAMP protein fic
CLOST_RS12785	COG2003	Belongs to the UPF0758 family
CLOST_RS12810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLOST_RS12835	COG1846	Transcriptional regulator
CLOST_RS12840	COG0384	phenazine biosynthesis protein PhzF
CLOST_RS12875	COG1475	DNA binding
CLOST_RS12880	COG1192	Involved in chromosome partitioning
CLOST_RS12885	COG1136	(ABC) transporter
CLOST_RS12890	COG0577	efflux transmembrane transporter activity
CLOST_RS12890	COG1136	(ABC) transporter
CLOST_RS12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOST_RS12900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLOST_RS12905	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLOST_RS12925	COG5002	protein histidine kinase activity
CLOST_RS12930	COG0745	RESPONSE REGULATOR receiver
CLOST_RS12945	COG2116	formate transmembrane transporter activity
CLOST_RS12950	COG2200	EAL domain
CLOST_RS12980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLOST_RS12990	COG0305	Participates in initiation and elongation during chromosome replication
CLOST_RS12995	COG0359	binds to the 23S rRNA
CLOST_RS13000	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLOST_RS13010	COG0431	NADPH-dependent FMN reductase
CLOST_RS13015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLOST_RS13020	COG0629	single-stranded DNA binding
CLOST_RS13025	COG0360	Binds together with S18 to 16S ribosomal RNA
CLOST_RS13030	COG4481	Protein conserved in bacteria
CLOST_RS13060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOST_RS13065	COG1475	DNA binding
CLOST_RS13070	COG0357	Ribosomal RNA small subunit methyltransferase G
CLOST_RS13075	COG0445	tRNA wobble uridine modification
CLOST_RS13080	COG1725	Transcriptional regulator
CLOST_RS13085	COG1131	(ABC) transporter
CLOST_RS13095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLOST_RS13100	COG1847	R3H domain protein
CLOST_RS13105	COG0706	membrane insertase activity
CLOST_RS13110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLOST_RS13115	COG0594	ribonuclease P activity
CLOST_RS13120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLOST_RS13325	COG2199	diguanylate cyclase activity
CLOST_RS13345	COG5001	Diguanylate cyclase
CLOST_RS13345	COG3447	MASE1 domain protein
CLOST_RS13345	COG5002	protein histidine kinase activity
CLOST_RS13350	COG2205	protein histidine kinase activity
CLOST_RS13350	COG0784	Response regulator, receiver
CLOST_RS13360	COG0840	transmembrane signaling receptor activity
CLOST_RS13370	COG0741	lytic transglycosylase activity
CLOST_RS13370	COG1196	nuclear chromosome segregation
CLOST_RS13370	COG0739	heme binding
CLOST_RS13410	COG0840	transmembrane signaling receptor activity
CLOST_RS13415	COG1846	Transcriptional regulator
CLOST_RS13425	COG1388	LysM domain
CLOST_RS13425	COG3103	Sh3 type 3 domain protein
CLOST_RS13425	COG0791	NLP P60 protein
CLOST_RS13435	COG1309	transcriptional regulator
CLOST_RS13460	COG3300	MHYT domain
CLOST_RS13460	COG5001	Diguanylate cyclase
CLOST_RS13470	COG4251	negative regulation of phosphorylation
CLOST_RS13470	COG2203	Gaf domain
CLOST_RS13470	COG5001	Diguanylate cyclase
CLOST_RS13470	COG3706	GGDEF domain
CLOST_RS13480	COG3437	response regulator, receiver
CLOST_RS13500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLOST_RS13510	COG3850	Histidine kinase
CLOST_RS13510	COG5002	protein histidine kinase activity
CLOST_RS13515	COG0739	heme binding
CLOST_RS13520	COG3852	Histidine kinase
CLOST_RS13525	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLOST_RS13545	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CLOST_RS13570	COG0791	NLP P60 protein
CLOST_RS13570	COG1388	LysM domain
CLOST_RS13570	COG3103	Sh3 type 3 domain protein
CLOST_RS13575	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLOST_RS13590	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLOST_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
CLOST_RS13610	COG1285	pathogenesis
CLOST_RS13620	COG2720	vancomycin resistance protein
CLOST_RS13640	COG0840	transmembrane signaling receptor activity
CLOST_RS13650	COG4251	negative regulation of phosphorylation
CLOST_RS13650	COG5001	Diguanylate cyclase
CLOST_RS13650	COG3706	GGDEF domain
CLOST_RS13650	COG2203	Gaf domain
CLOST_RS13655	COG4251	negative regulation of phosphorylation
CLOST_RS13655	COG5001	Diguanylate cyclase
CLOST_RS13655	COG3706	GGDEF domain
CLOST_RS13655	COG2203	Gaf domain
CLOST_RS13660	COG3693	PFAM glycoside hydrolase, family 10
CLOST_RS13670	COG2340	Cysteine-rich secretory protein family
CLOST_RS13675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOST_RS13675	COG4191	Histidine kinase