locus-tag	class	description
CTK_RS00010	COG0592	DNA-directed DNA polymerase activity
CTK_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTK_RS00030	COG0187	DNA topoisomerase II activity
CTK_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTK_RS00070	COG1827	regulation of RNA biosynthetic process
CTK_RS00075	COG1615	UPF0182 protein
CTK_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CTK_RS00130	COG0688	phosphatidylethanolamine metabolic process
CTK_RS00165	COG2814	Major facilitator Superfamily
CTK_RS00185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTK_RS00190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CTK_RS00210	COG1489	DNA binding
CTK_RS00215	COG2816	NAD+ diphosphatase activity
CTK_RS00230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTK_RS00230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CTK_RS00235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTK_RS00245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CTK_RS00285	COG1363	Peptidase, m42
CTK_RS00295	COG2267	carboxylic ester hydrolase activity
CTK_RS00305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CTK_RS00330	COG1619	proteins homologs of microcin C7 resistance protein MccF
CTK_RS00345	COG1982	Orn Lys Arg decarboxylase major
CTK_RS00355	COG3870	Protein conserved in bacteria
CTK_RS00360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTK_RS00365	COG1774	PSP1 C-terminal conserved region
CTK_RS00380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CTK_RS00385	COG1360	Flagellar Motor Protein
CTK_RS00390	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CTK_RS00395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CTK_RS00405	COG2002	toxin-antitoxin pair type II binding
CTK_RS00410	COG0617	tRNA 3'-terminal CCA addition
CTK_RS00435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CTK_RS00445	COG0726	polysaccharide deacetylase
CTK_RS00450	COG4193	domain, Protein
CTK_RS00455	COG1573	uracil-dna glycosylase
CTK_RS00460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTK_RS00460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTK_RS00470	COG0084	hydrolase, TatD family'
CTK_RS00475	COG3584	3D domain protein
CTK_RS00475	COG3583	domain protein
CTK_RS00480	COG0784	Response regulator, receiver
CTK_RS00485	COG4191	Histidine kinase
CTK_RS00535	COG1328	CTP reductase activity
CTK_RS00545	COG0640	Transcriptional regulator
CTK_RS00550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTK_RS00555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CTK_RS00565	COG0586	Pfam SNARE associated Golgi protein
CTK_RS00570	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CTK_RS00590	COG2094	Belongs to the DNA glycosylase MPG family
CTK_RS00595	COG2186	Transcriptional regulator
CTK_RS00600	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CTK_RS00605	COG1691	(AIR) carboxylase
CTK_RS00645	COG0438	transferase activity, transferring glycosyl groups
CTK_RS00660	COG4466	Protein conserved in bacteria
CTK_RS00665	COG3858	chitin binding
CTK_RS00665	COG1388	LysM domain
CTK_RS00675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTK_RS00675	COG0189	ligase activity
CTK_RS00680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CTK_RS00685	COG0697	spore germination
CTK_RS00690	COG0814	amino acid
CTK_RS00700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTK_RS00705	COG2959	enzyme of heme biosynthesis
CTK_RS00720	COG0504	CTP synthase activity
CTK_RS00725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CTK_RS00730	COG0254	rRNA binding
CTK_RS00735	COG1435	thymidine kinase activity
CTK_RS00740	COG3872	metal-dependent enzyme
CTK_RS00750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CTK_RS00760	COG0428	transporter
CTK_RS00765	COG0009	L-threonylcarbamoyladenylate synthase
CTK_RS00770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CTK_RS00775	COG0698	ribose 5-phosphate isomerase
CTK_RS00785	COG2131	deaminase
CTK_RS00790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTK_RS00795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CTK_RS00800	COG0183	Belongs to the thiolase family
CTK_RS00810	COG0356	it plays a direct role in the translocation of protons across the membrane
CTK_RS00815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTK_RS00820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CTK_RS00825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTK_RS00835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CTK_RS00840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CTK_RS00845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CTK_RS00860	COG2385	sporulation resulting in formation of a cellular spore
CTK_RS00870	COG1609	Transcriptional regulator
CTK_RS00875	COG1077	Cell shape determining protein MreB Mrl
CTK_RS00910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CTK_RS00920	COG1040	competence protein
CTK_RS00925	COG1278	Cold shock
CTK_RS00935	COG0653	protein targeting
CTK_RS00940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CTK_RS00950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTK_RS00955	COG0577	efflux transmembrane transporter activity
CTK_RS00955	COG1136	(ABC) transporter
CTK_RS00960	COG0577	efflux transmembrane transporter activity
CTK_RS00975	COG2183	response to ionizing radiation
CTK_RS01010	COG2357	RelA SpoT domain protein
CTK_RS01015	COG0495	leucyl-tRNA aminoacylation
CTK_RS01030	COG0484	heat shock protein binding
CTK_RS01045	COG0191	fructose-bisphosphate aldolase activity
CTK_RS01055	COG2323	membrane
CTK_RS01060	COG0572	uridine kinase
CTK_RS01065	COG1760	l-serine dehydratase
CTK_RS01070	COG1760	l-serine dehydratase
CTK_RS01075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CTK_RS01080	COG0248	Ppx GppA phosphatase
CTK_RS01080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CTK_RS01085	COG0248	Ppx GppA phosphatase
CTK_RS01100	COG1183	phosphatidylcholine synthase activity
CTK_RS01105	COG0398	Pfam SNARE associated Golgi protein
CTK_RS01110	COG0517	IMP dehydrogenase activity
CTK_RS01115	COG1597	lipid kinase activity
CTK_RS01135	COG2239	Acts as a magnesium transporter
CTK_RS01145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTK_RS01150	COG1045	serine acetyltransferase
CTK_RS01155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTK_RS01165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CTK_RS01170	COG1546	Belongs to the CinA family
CTK_RS01170	COG1058	Belongs to the CinA family
CTK_RS01175	COG2720	vancomycin resistance protein
CTK_RS01195	COG1971	Probably functions as a manganese efflux pump
CTK_RS01200	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CTK_RS01210	COG1307	EDD domain protein, DegV family
CTK_RS01220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CTK_RS01225	COG2390	Transcriptional regulator
CTK_RS01230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CTK_RS01245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CTK_RS01250	COG0148	phosphopyruvate hydratase activity
CTK_RS01275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CTK_RS01280	COG0557	exoribonuclease II activity
CTK_RS01285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CTK_RS01295	COG0584	glycerophosphoryl diester phosphodiesterase
CTK_RS01305	COG1846	Transcriptional regulator
CTK_RS01365	COG3069	C4-dicarboxylate transmembrane transporter activity
CTK_RS01370	COG2214	Heat shock protein DnaJ domain protein
CTK_RS01375	COG0443	Heat shock 70 kDa protein
CTK_RS01385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTK_RS01390	COG1621	beta-fructofuranosidase activity
CTK_RS01395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTK_RS01400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTK_RS01415	COG5577	PFAM Coat F domain
CTK_RS01430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTK_RS01470	COG1126	abc transporter atp-binding protein
CTK_RS01475	COG0765	amino acid transport
CTK_RS01480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTK_RS01485	COG0583	DNA-binding transcription factor activity
CTK_RS01495	COG5275	peptidyl-tyrosine sulfation
CTK_RS01495	COG0252	asparaginase activity
CTK_RS01505	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CTK_RS01520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CTK_RS01525	COG1733	regulation of RNA biosynthetic process
CTK_RS01530	COG0778	Nitroreductase
CTK_RS01555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CTK_RS01560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CTK_RS01585	COG2814	Major facilitator Superfamily
CTK_RS01590	COG1151	hydroxylamine reductase activity
CTK_RS01600	COG0426	domain, Protein
CTK_RS01600	COG1773	rubredoxin
CTK_RS01625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTK_RS01630	COG0765	amino acid transport
CTK_RS01640	COG1126	abc transporter atp-binding protein
CTK_RS01645	COG1834	amidinotransferase
CTK_RS01660	COG4187	Peptidase family M20/M25/M40
CTK_RS01665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CTK_RS01670	COG0436	Aminotransferase
CTK_RS01685	COG0384	phenazine biosynthesis protein PhzF
CTK_RS01690	COG4106	trans-aconitate 2-methyltransferase activity
CTK_RS01700	COG1846	Transcriptional regulator
CTK_RS01705	COG0371	Dehydrogenase
CTK_RS01720	COG1595	DNA-templated transcription, initiation
CTK_RS01735	COG1686	Belongs to the peptidase S11 family
CTK_RS01790	COG4978	Transcriptional regulator
CTK_RS01790	COG0789	Transcriptional regulator
CTK_RS01800	COG3655	Transcriptional regulator
CTK_RS01805	COG1032	radical SAM domain protein
CTK_RS01840	COG2076	Multidrug Resistance protein
CTK_RS01860	COG1819	glycosyl
CTK_RS01875	COG3547	Transposase (IS116 IS110 IS902 family)
CTK_RS01890	COG1595	DNA-templated transcription, initiation
CTK_RS01895	COG0693	protein deglycase activity
CTK_RS01935	COG0477	Major facilitator Superfamily
CTK_RS01950	COG2814	Major facilitator Superfamily
CTK_RS01990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CTK_RS01995	COG0561	phosphatase activity
CTK_RS02010	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTK_RS02025	COG2818	Glycosylase
CTK_RS02035	COG3655	Transcriptional regulator
CTK_RS02040	COG0662	Cupin 2, conserved barrel domain protein
CTK_RS02060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS02065	COG1116	anion transmembrane transporter activity
CTK_RS02070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTK_RS02095	COG0697	spore germination
CTK_RS02100	COG2326	polyphosphate kinase activity
CTK_RS02105	COG3594	Acyltransferase
CTK_RS02115	COG0367	asparagine synthase
CTK_RS02120	COG0534	Mate efflux family protein
CTK_RS02125	COG5599	Phosphatase
CTK_RS02130	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CTK_RS02140	COG2205	protein histidine kinase activity
CTK_RS02140	COG2202	Pas domain
CTK_RS02145	COG0037	tRNA processing
CTK_RS02155	COG0477	Major facilitator Superfamily
CTK_RS02160	COG0789	Transcriptional regulator
CTK_RS02165	COG2814	Major facilitator Superfamily
CTK_RS02185	COG2247	cell wall binding repeat
CTK_RS02185	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTK_RS02240	COG0546	phosphoglycolate phosphatase activity
CTK_RS02255	COG1511	domain protein
CTK_RS02290	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTK_RS02290	COG2247	cell wall binding repeat
CTK_RS02300	COG2247	cell wall binding repeat
CTK_RS02300	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTK_RS02310	COG3944	biosynthesis protein
CTK_RS02320	COG0489	protein tyrosine kinase activity
CTK_RS02325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTK_RS02360	COG2244	polysaccharide biosynthetic process
CTK_RS02385	COG1091	dTDP-4-dehydrorhamnose reductase activity
CTK_RS02395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CTK_RS02425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CTK_RS02450	COG3875	lactate racemase activity
CTK_RS02465	COG1215	transferase activity, transferring glycosyl groups
CTK_RS02475	COG4145	pantothenate transmembrane transporter activity
CTK_RS02480	COG0747	negative chemotaxis
CTK_RS02485	COG0601	transmembrane transport
CTK_RS02490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTK_RS02495	COG0444	Belongs to the ABC transporter superfamily
CTK_RS02500	COG4608	Belongs to the ABC transporter superfamily
CTK_RS02510	COG0477	Major facilitator Superfamily
CTK_RS02515	COG1309	transcriptional regulator
CTK_RS02525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTK_RS02560	COG2814	Major facilitator Superfamily
CTK_RS02570	COG0697	spore germination
CTK_RS02580	COG0531	amino acid
CTK_RS02585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTK_RS02590	COG2213	PTS system mannitol-specific
CTK_RS02595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTK_RS02595	COG3711	transcriptional antiterminator
CTK_RS02600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTK_RS02605	COG0246	Mannitol dehydrogenase
CTK_RS02610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTK_RS02615	COG0477	Major facilitator Superfamily
CTK_RS02620	COG1349	DNA-binding transcription factor activity
CTK_RS02625	COG1454	alcohol dehydrogenase
CTK_RS02635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTK_RS02640	COG3718	enzyme involved in inositol metabolism
CTK_RS02650	COG2814	Major facilitator Superfamily
CTK_RS02685	COG0798	PFAM Bile acid sodium symporter
CTK_RS02695	COG3682	Transcriptional regulator
CTK_RS02710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTK_RS02715	COG0583	DNA-binding transcription factor activity
CTK_RS02735	COG0778	Nitroreductase
CTK_RS02745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CTK_RS02750	COG1247	-acetyltransferase
CTK_RS02755	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CTK_RS02775	COG1733	regulation of RNA biosynthetic process
CTK_RS02780	COG0789	Transcriptional regulator
CTK_RS02785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTK_RS02795	COG1486	melibiose metabolic process
CTK_RS02800	COG1737	Transcriptional regulator
CTK_RS02805	COG3711	transcriptional antiterminator
CTK_RS02810	COG1263	PTS System
CTK_RS02810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CTK_RS02810	COG2190	(PTS) system
CTK_RS02815	COG0531	amino acid
CTK_RS02830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CTK_RS02835	COG0840	transmembrane signaling receptor activity
CTK_RS02850	COG0303	'Molybdopterin
CTK_RS02860	COG0746	molybdenum cofactor guanylyltransferase activity
CTK_RS02900	COG1404	Belongs to the peptidase S8 family
CTK_RS02915	COG1132	(ABC) transporter
CTK_RS02925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CTK_RS02930	COG1522	sequence-specific DNA binding
CTK_RS02935	COG1346	cytolysis
CTK_RS02945	COG0840	transmembrane signaling receptor activity
CTK_RS02950	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CTK_RS02960	COG0295	cytidine deaminase activity
CTK_RS02965	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CTK_RS02970	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CTK_RS02975	COG0436	Aminotransferase
CTK_RS02985	COG0840	transmembrane signaling receptor activity
CTK_RS02990	COG3527	Alpha-acetolactate decarboxylase
CTK_RS03000	COG1027	Aspartate ammonia-lyase
CTK_RS03025	COG4708	membrane
CTK_RS03045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTK_RS03060	COG1349	DNA-binding transcription factor activity
CTK_RS03065	COG1105	Belongs to the carbohydrate kinase PfkB family
CTK_RS03070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTK_RS03070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTK_RS03070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CTK_RS03080	COG0735	belongs to the Fur family
CTK_RS03100	COG0457	Tetratricopeptide repeat
CTK_RS03100	COG0705	Rhomboid family
CTK_RS03105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTK_RS03120	COG1396	sequence-specific DNA binding
CTK_RS03125	COG0697	spore germination
CTK_RS03140	COG0542	response to heat
CTK_RS03145	COG0427	acetyl-CoA hydrolase
CTK_RS03150	COG3442	glutamine amidotransferase
CTK_RS03155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTK_RS03160	COG0697	spore germination
CTK_RS03195	COG0697	spore germination
CTK_RS03200	COG2333	competence protein COMEC
CTK_RS03200	COG0658	competence protein
CTK_RS03210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTK_RS03215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTK_RS03220	COG0473	3-isopropylmalate dehydrogenase activity
CTK_RS03225	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CTK_RS03230	COG1410	methionine synthase
CTK_RS03230	COG0646	methionine synthase
CTK_RS03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTK_RS03245	COG0765	amino acid transport
CTK_RS03250	COG1126	abc transporter atp-binding protein
CTK_RS03255	COG0137	argininosuccinate synthase activity
CTK_RS03260	COG0165	Argininosuccinate lyase
CTK_RS03265	COG2155	Conserved Protein
CTK_RS03270	COG1522	sequence-specific DNA binding
CTK_RS03275	COG0017	Asparaginyl-tRNA synthetase
CTK_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
CTK_RS03295	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CTK_RS03300	COG0667	Aldo Keto reductase
CTK_RS03315	COG3829	transcription factor binding
CTK_RS03315	COG3290	protein histidine kinase activity
CTK_RS03340	COG1960	acyl-CoA dehydrogenase activity
CTK_RS03350	COG0735	belongs to the Fur family
CTK_RS03370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTK_RS03385	COG0697	spore germination
CTK_RS03400	COG0697	spore germination
CTK_RS03420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTK_RS03420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTK_RS03425	COG0475	glutathione-regulated potassium exporter activity
CTK_RS03440	COG1846	Transcriptional regulator
CTK_RS03450	COG1132	(ABC) transporter
CTK_RS03460	COG0745	RESPONSE REGULATOR receiver
CTK_RS03465	COG3850	Histidine kinase
CTK_RS03465	COG5002	protein histidine kinase activity
CTK_RS03475	COG0004	ammonium transporteR
CTK_RS03480	COG0347	Belongs to the P(II) protein family
CTK_RS03495	COG1285	pathogenesis
CTK_RS03500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CTK_RS03505	COG3546	catalase activity
CTK_RS03555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTK_RS03565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CTK_RS03580	COG1929	Belongs to the glycerate kinase type-1 family
CTK_RS03585	COG1473	amidohydrolase
CTK_RS03590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CTK_RS03590	COG0517	IMP dehydrogenase activity
CTK_RS03595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CTK_RS03605	COG0039	L-malate dehydrogenase activity
CTK_RS03615	COG0318	PFAM AMP-dependent synthetase and ligase
CTK_RS03630	COG3290	protein histidine kinase activity
CTK_RS03630	COG3829	transcription factor binding
CTK_RS03635	COG2207	Transcriptional regulator
CTK_RS03635	COG1917	Cupin 2, conserved barrel domain protein
CTK_RS03640	COG1082	Xylose isomerase domain protein TIM barrel
CTK_RS03645	COG3962	Belongs to the TPP enzyme family
CTK_RS03650	COG1082	Xylose isomerase domain protein TIM barrel
CTK_RS03655	COG0673	inositol 2-dehydrogenase activity
CTK_RS03665	COG3959	Transketolase, thiamine diphosphate binding domain
CTK_RS03670	COG3958	Transketolase
CTK_RS03675	COG2814	Major facilitator Superfamily
CTK_RS03680	COG0673	inositol 2-dehydrogenase activity
CTK_RS03685	COG2814	Major facilitator Superfamily
CTK_RS03695	COG1454	alcohol dehydrogenase
CTK_RS03705	COG0205	6-phosphofructokinase activity
CTK_RS03720	COG0427	acetyl-CoA hydrolase
CTK_RS03745	COG1619	proteins homologs of microcin C7 resistance protein MccF
CTK_RS03765	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CTK_RS03765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CTK_RS03770	COG0583	DNA-binding transcription factor activity
CTK_RS03775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTK_RS03780	COG2964	Protein conserved in bacteria
CTK_RS03795	COG3845	ABC transporter
CTK_RS03800	COG4603	Belongs to the binding-protein-dependent transport system permease family
CTK_RS03805	COG1079	Belongs to the binding-protein-dependent transport system permease family
CTK_RS03810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CTK_RS03810	COG3608	succinylglutamate desuccinylase aspartoacylase
CTK_RS03830	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CTK_RS03835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CTK_RS03845	COG0402	S-adenosylhomocysteine deaminase activity
CTK_RS03850	COG0167	dihydroorotate dehydrogenase activity
CTK_RS03880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CTK_RS03885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTK_RS03890	COG1120	ATPase activity
CTK_RS03905	COG0745	RESPONSE REGULATOR receiver
CTK_RS03910	COG3850	Histidine kinase
CTK_RS03910	COG5002	protein histidine kinase activity
CTK_RS03915	COG2814	Major facilitator Superfamily
CTK_RS03925	COG0586	Pfam SNARE associated Golgi protein
CTK_RS03930	COG0671	phosphoesterase, PA-phosphatase related
CTK_RS03940	COG0390	transport system, permease component
CTK_RS03945	COG4619	ABC transporter
CTK_RS03950	COG0583	DNA-binding transcription factor activity
CTK_RS03955	COG0436	Aminotransferase
CTK_RS03960	COG0194	GDP metabolic process
CTK_RS03980	COG0725	ABC transporter, periplasmic molybdate-binding protein
CTK_RS03985	COG4149	molybdate abc transporter
CTK_RS04000	COG1278	Cold shock
CTK_RS04010	COG1253	flavin adenine dinucleotide binding
CTK_RS04015	COG0310	cobalt ion transport
CTK_RS04020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CTK_RS04025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CTK_RS04030	COG2199	diguanylate cyclase activity
CTK_RS04030	COG2203	Gaf domain
CTK_RS04035	COG1074	ATP-dependent DNA helicase activity
CTK_RS04040	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTK_RS04045	COG0765	amino acid transport
CTK_RS04060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CTK_RS04065	COG0351	phosphomethylpyrimidine kinase
CTK_RS04065	COG0352	thiamine-phosphate diphosphorylase activity
CTK_RS04070	COG1136	(ABC) transporter
CTK_RS04075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CTK_RS04080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTK_RS04095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTK_RS04110	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CTK_RS04120	COG0438	transferase activity, transferring glycosyl groups
CTK_RS04125	COG0463	Glycosyl transferase, family 2
CTK_RS04125	COG0457	Tetratricopeptide repeat
CTK_RS04160	COG0826	peptidase U32
CTK_RS04165	COG1193	negative regulation of DNA recombination
CTK_RS04175	COG1982	Orn Lys Arg decarboxylase major
CTK_RS04180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTK_RS04190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CTK_RS04230	COG0438	transferase activity, transferring glycosyl groups
CTK_RS04260	COG0728	peptidoglycan biosynthetic process
CTK_RS04270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTK_RS04275	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CTK_RS04280	COG1959	2 iron, 2 sulfur cluster binding
CTK_RS04300	COG2172	sigma factor antagonist activity
CTK_RS04305	COG1191	sigma factor activity
CTK_RS04315	COG1773	rubredoxin
CTK_RS04325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTK_RS04335	COG1739	Uncharacterized protein family UPF0029
CTK_RS04345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CTK_RS04360	COG2255	four-way junction helicase activity
CTK_RS04365	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTK_RS04375	COG1862	Preprotein translocase
CTK_RS04395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTK_RS04400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTK_RS04405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTK_RS04410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTK_RS04415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTK_RS04420	COG1490	D-aminoacyl-tRNA deacylase activity
CTK_RS04425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTK_RS04430	COG0124	histidyl-tRNA synthetase
CTK_RS04435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTK_RS04450	COG1272	protein, Hemolysin III
CTK_RS04455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTK_RS04465	COG0157	Belongs to the NadC ModD family
CTK_RS04475	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CTK_RS04480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CTK_RS04485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CTK_RS04490	COG1979	alcohol dehydrogenase
CTK_RS04505	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CTK_RS04510	COG1953	Uracil, thiamine, allantoin
CTK_RS04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTK_RS04535	COG1122	ATPase activity
CTK_RS04555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CTK_RS04565	COG0181	hydroxymethylbilane synthase activity
CTK_RS04575	COG0113	porphobilinogen synthase activity
CTK_RS04605	COG2242	protein methyltransferase activity
CTK_RS04645	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CTK_RS04650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTK_RS04665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTK_RS04670	COG1121	(ABC) transporter
CTK_RS04680	COG0582	viral genome integration into host DNA
CTK_RS04755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTK_RS04830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTK_RS04840	COG5484	DNA packaging
CTK_RS04845	COG1783	phage Terminase large subunit
CTK_RS05035	COG2076	Multidrug Resistance protein
CTK_RS05060	COG0582	viral genome integration into host DNA
CTK_RS05135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTK_RS05210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTK_RS05220	COG5484	DNA packaging
CTK_RS05225	COG1783	phage Terminase large subunit
CTK_RS05415	COG2076	Multidrug Resistance protein
CTK_RS05480	COG0840	transmembrane signaling receptor activity
CTK_RS05515	COG1376	ErfK ybiS ycfS ynhG family protein
CTK_RS05520	COG1525	nuclease
CTK_RS05535	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CTK_RS05540	COG5434	Belongs to the glycosyl hydrolase 28 family
CTK_RS05540	COG4632	Exopolysaccharide biosynthesis protein
CTK_RS05550	COG1994	Peptidase M50
CTK_RS05555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CTK_RS05560	COG0302	gtp cyclohydrolase
CTK_RS05565	COG1418	mRNA catabolic process
CTK_RS05570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTK_RS05575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTK_RS05575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CTK_RS05585	COG1346	cytolysis
CTK_RS05600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CTK_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
CTK_RS05610	COG2197	response regulator
CTK_RS05625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CTK_RS05630	COG0710	3-dehydroquinate dehydratase activity
CTK_RS05645	COG1937	Protein conserved in bacteria
CTK_RS05650	COG2217	Heavy metal translocating P-type atpase
CTK_RS05660	COG2217	Heavy metal translocating P-type atpase
CTK_RS05665	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CTK_RS05670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTK_RS05705	COG4684	Psort location CytoplasmicMembrane, score
CTK_RS05710	COG3191	aminopeptidase activity
CTK_RS05720	COG0539	negative regulation of cytoplasmic translation
CTK_RS05725	COG3300	MHYT domain
CTK_RS05725	COG5001	Diguanylate cyclase
CTK_RS05750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CTK_RS05760	COG1074	ATP-dependent DNA helicase activity
CTK_RS05780	COG1104	cysteine desulfurase activity
CTK_RS05785	COG0301	tRNA thio-modification
CTK_RS05790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CTK_RS05800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CTK_RS05805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CTK_RS05810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CTK_RS05820	COG0396	ATPase activity
CTK_RS05825	COG0719	Fe-S assembly protein
CTK_RS05830	COG0719	Fe-S assembly protein
CTK_RS05835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CTK_RS05840	COG0822	iron-sulfur transferase activity
CTK_RS05850	COG3290	protein histidine kinase activity
CTK_RS05865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CTK_RS05890	COG4555	ABC transporter
CTK_RS05895	COG1668	transmembrane transport
CTK_RS05900	COG2814	Major facilitator Superfamily
CTK_RS05905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CTK_RS05920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTK_RS05925	COG2226	methyltransferase
CTK_RS05930	COG0006	proline dipeptidase activity
CTK_RS05935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTK_RS05945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CTK_RS05955	COG2022	thiamine diphosphate biosynthetic process
CTK_RS05965	COG0352	thiamine-phosphate diphosphorylase activity
CTK_RS05980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CTK_RS05995	COG1234	tRNA 3'-trailer cleavage
CTK_RS06020	COG2508	Transcriptional regulator
CTK_RS06040	COG1953	Uracil, thiamine, allantoin
CTK_RS06075	COG4221	oxidoreductase activity
CTK_RS06085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTK_RS06100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CTK_RS06115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CTK_RS06125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS06130	COG1116	anion transmembrane transporter activity
CTK_RS06150	COG0514	ATP-dependent DNA helicase (RecQ)
CTK_RS06160	COG0179	Fumarylacetoacetate (FAA) hydrolase
CTK_RS06175	COG0505	Belongs to the CarA family
CTK_RS06180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTK_RS06185	COG0644	oxidoreductase
CTK_RS06190	COG0529	Catalyzes the synthesis of activated sulfate
CTK_RS06210	COG1116	anion transmembrane transporter activity
CTK_RS06215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS06220	COG0175	sulfate reduction
CTK_RS06225	COG2895	sulfate adenylyltransferase (ATP) activity
CTK_RS06225	COG0529	Catalyzes the synthesis of activated sulfate
CTK_RS06230	COG1396	sequence-specific DNA binding
CTK_RS06235	COG0840	transmembrane signaling receptor activity
CTK_RS06250	COG3874	Sporulation protein YtfJ
CTK_RS06260	COG1686	Belongs to the peptidase S11 family
CTK_RS06275	COG4656	Part of a membrane complex involved in electron transport
CTK_RS06280	COG4658	electron transport chain
CTK_RS06285	COG4659	FMN binding
CTK_RS06290	COG4660	Part of a membrane complex involved in electron transport
CTK_RS06295	COG4657	Part of a membrane complex involved in electron transport
CTK_RS06300	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTK_RS06300	COG2878	Part of a membrane complex involved in electron transport
CTK_RS06315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CTK_RS06320	COG0022	dehydrogenase e1 component
CTK_RS06325	COG0508	dehydrogenase complex catalyzes the overall conversion of
CTK_RS06330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CTK_RS06345	COG0840	transmembrane signaling receptor activity
CTK_RS06370	COG0745	RESPONSE REGULATOR receiver
CTK_RS06375	COG5002	protein histidine kinase activity
CTK_RS06385	COG1174	glycine betaine transport
CTK_RS06390	COG1368	sulfuric ester hydrolase activity
CTK_RS06400	COG0436	Aminotransferase
CTK_RS06410	COG0628	permease
CTK_RS06420	COG1725	Transcriptional regulator
CTK_RS06425	COG1131	(ABC) transporter
CTK_RS06435	COG1307	EDD domain protein, DegV family
CTK_RS06440	COG0402	S-adenosylhomocysteine deaminase activity
CTK_RS06450	COG0709	Synthesizes selenophosphate from selenide and ATP
CTK_RS06460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTK_RS06470	COG3608	succinylglutamate desuccinylase aspartoacylase
CTK_RS06470	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CTK_RS06480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CTK_RS06485	COG0542	response to heat
CTK_RS06500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CTK_RS06510	COG0517	IMP dehydrogenase activity
CTK_RS06510	COG4175	Glycine betaine
CTK_RS06515	COG4176	ABC-type proline glycine betaine transport system permease component
CTK_RS06525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTK_RS06530	COG0840	transmembrane signaling receptor activity
CTK_RS06535	COG0367	asparagine synthase
CTK_RS06545	COG0697	spore germination
CTK_RS06550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CTK_RS06555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTK_RS06560	COG0513	Belongs to the DEAD box helicase family
CTK_RS06565	COG1464	Belongs to the NlpA lipoprotein family
CTK_RS06570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CTK_RS06575	COG2011	ABC-type metal ion transport system permease component
CTK_RS06580	COG0277	FAD linked oxidase domain protein
CTK_RS06600	COG4336	lyase activity
CTK_RS06605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CTK_RS06615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CTK_RS06620	COG1984	allophanate hydrolase subunit 2
CTK_RS06625	COG0511	ligase activity, forming carbon-carbon bonds
CTK_RS06630	COG0439	Biotin carboxylase
CTK_RS06635	COG1131	(ABC) transporter
CTK_RS06700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTK_RS06705	COG1120	ATPase activity
CTK_RS06725	COG0745	RESPONSE REGULATOR receiver
CTK_RS06730	COG2205	protein histidine kinase activity
CTK_RS06740	COG2814	Major facilitator Superfamily
CTK_RS06745	COG1960	acyl-CoA dehydrogenase activity
CTK_RS06750	COG1550	Protein conserved in bacteria
CTK_RS06755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CTK_RS06765	COG2323	membrane
CTK_RS06780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CTK_RS06785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CTK_RS06790	COG0626	cystathionine gamma-synthase activity
CTK_RS06795	COG0681	Belongs to the peptidase S26 family
CTK_RS06810	COG0583	DNA-binding transcription factor activity
CTK_RS06815	COG2201	protein-glutamate methylesterase activity
CTK_RS06835	COG1132	(ABC) transporter
CTK_RS06850	COG0840	transmembrane signaling receptor activity
CTK_RS06850	COG3290	protein histidine kinase activity
CTK_RS06855	COG0326	Molecular chaperone. Has ATPase activity
CTK_RS06865	COG0768	penicillin binding
CTK_RS06870	COG1278	Cold shock
CTK_RS06900	COG0745	RESPONSE REGULATOR receiver
CTK_RS06915	COG5002	protein histidine kinase activity
CTK_RS06920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CTK_RS06925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTK_RS06945	COG0745	RESPONSE REGULATOR receiver
CTK_RS06965	COG0840	transmembrane signaling receptor activity
CTK_RS06975	COG2226	methyltransferase
CTK_RS06980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CTK_RS06990	COG0105	UTP biosynthetic process
CTK_RS07000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CTK_RS07005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CTK_RS07015	COG0393	Putative heavy-metal-binding
CTK_RS07020	COG0488	(ABC) transporter
CTK_RS07050	COG0577	efflux transmembrane transporter activity
CTK_RS07050	COG1136	(ABC) transporter
CTK_RS07060	COG0745	RESPONSE REGULATOR receiver
CTK_RS07065	COG3850	Histidine kinase
CTK_RS07065	COG5002	protein histidine kinase activity
CTK_RS07075	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CTK_RS07085	COG3328	transposase activity
CTK_RS07130	COG2217	Heavy metal translocating P-type atpase
CTK_RS07135	COG5002	protein histidine kinase activity
CTK_RS07140	COG2247	cell wall binding repeat
CTK_RS07140	COG2385	sporulation resulting in formation of a cellular spore
CTK_RS07155	COG0745	RESPONSE REGULATOR receiver
CTK_RS07175	COG2873	o-acetylhomoserine
CTK_RS07210	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CTK_RS07220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS07235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS07240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS07245	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CTK_RS07250	COG0613	PHP domain protein
CTK_RS07265	COG2873	o-acetylhomoserine
CTK_RS07275	COG1592	Rubrerythrin
CTK_RS07285	COG2703	oxygen carrier activity
CTK_RS07290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTK_RS07295	COG1592	Rubrerythrin
CTK_RS07300	COG0833	amino acid
CTK_RS07315	COG0535	radical SAM domain protein
CTK_RS07315	COG1433	Dinitrogenase iron-molybdenum cofactor
CTK_RS07320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTK_RS07325	COG0626	cystathionine gamma-synthase activity
CTK_RS07330	COG2226	methyltransferase
CTK_RS07355	COG1940	carbohydrate kinase activity
CTK_RS07360	COG1742	UPF0060 membrane protein
CTK_RS07370	COG1752	Esterase of the alpha-beta hydrolase superfamily
CTK_RS07375	COG0215	cysteine-tRNA ligase activity
CTK_RS07385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CTK_RS07390	COG1215	transferase activity, transferring glycosyl groups
CTK_RS07395	COG1187	pseudouridine synthase activity
CTK_RS07400	COG1737	Transcriptional regulator
CTK_RS07405	COG2081	HI0933 family
CTK_RS07420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CTK_RS07420	COG0539	negative regulation of cytoplasmic translation
CTK_RS07435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTK_RS07440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTK_RS07445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTK_RS07455	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CTK_RS07460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTK_RS07470	COG4974	Belongs to the 'phage' integrase family
CTK_RS07485	COG1924	4 iron, 4 sulfur cluster binding
CTK_RS07490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTK_RS07500	COG0300	oxidoreductase activity
CTK_RS07515	COG0133	tryptophan synthase activity
CTK_RS07520	COG0135	phosphoribosylanthranilate isomerase activity
CTK_RS07525	COG0134	indole-3-glycerol-phosphate synthase activity
CTK_RS07530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTK_RS07535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTK_RS07535	COG0512	Glutamine amidotransferase of anthranilate synthase
CTK_RS07550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTK_RS07560	COG0277	FAD linked oxidase domain protein
CTK_RS07565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTK_RS07570	COG2086	electron transfer activity
CTK_RS07575	COG3875	lactate racemase activity
CTK_RS07580	COG1620	l-lactate permease
CTK_RS07585	COG2186	Transcriptional regulator
CTK_RS07610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CTK_RS07610	COG0517	IMP dehydrogenase activity
CTK_RS07620	COG0018	arginyl-trna synthetase
CTK_RS07630	COG1177	transmembrane transport
CTK_RS07640	COG3842	ATPase activity
CTK_RS07645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CTK_RS07650	COG4208	sulfate ABC transporter
CTK_RS07660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CTK_RS07670	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CTK_RS07680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS07685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTK_RS07700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTK_RS07705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CTK_RS07710	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CTK_RS07715	COG1940	carbohydrate kinase activity
CTK_RS07715	COG1846	Transcriptional regulator
CTK_RS07720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CTK_RS07740	COG1116	anion transmembrane transporter activity
CTK_RS07745	COG4521	taurine ABC transporter
CTK_RS07750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS07765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTK_RS07765	COG1918	ferrous iron import across plasma membrane
CTK_RS07775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTK_RS07775	COG1918	ferrous iron import across plasma membrane
CTK_RS07785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTK_RS07795	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CTK_RS07805	COG1254	Belongs to the acylphosphatase family
CTK_RS07810	COG1063	alcohol dehydrogenase
CTK_RS07845	COG0069	glutamate synthase activity
CTK_RS07845	COG0070	glutamate synthase
CTK_RS07845	COG0067	glutamate synthase
CTK_RS07855	COG2610	gluconate transmembrane transporter activity
CTK_RS07860	COG3395	kinase activity
CTK_RS07870	COG1349	DNA-binding transcription factor activity
CTK_RS07875	COG0482	sulfurtransferase activity
CTK_RS07890	COG1250	3-hydroxyacyl-CoA dehydrogenase
CTK_RS07895	COG2031	fatty acid transporter
CTK_RS07910	COG0028	Belongs to the TPP enzyme family
CTK_RS07920	COG0129	dihydroxy-acid dehydratase activity
CTK_RS07925	COG0028	Belongs to the TPP enzyme family
CTK_RS07930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CTK_RS07940	COG0011	TIGRFAM Protein of
CTK_RS07950	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CTK_RS07965	COG2610	gluconate transmembrane transporter activity
CTK_RS07975	COG3290	protein histidine kinase activity
CTK_RS07975	COG3829	transcription factor binding
CTK_RS07990	COG2378	regulation of single-species biofilm formation
CTK_RS07995	COG2030	dehydratase
CTK_RS08010	COG1695	Transcriptional regulator
CTK_RS08015	COG1854	S-ribosylhomocysteine lyase activity
CTK_RS08020	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CTK_RS08025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CTK_RS08030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CTK_RS08040	COG0789	Transcriptional regulator
CTK_RS08045	COG1611	Belongs to the LOG family
CTK_RS08060	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTK_RS08065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CTK_RS08070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CTK_RS08075	COG0583	DNA-binding transcription factor activity
CTK_RS08080	COG3118	belongs to the thioredoxin family
CTK_RS08090	COG4521	taurine ABC transporter
CTK_RS08095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS08100	COG3118	belongs to the thioredoxin family
CTK_RS08110	COG2076	Multidrug Resistance protein
CTK_RS08125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CTK_RS08130	COG4302	ethanolamine ammonia-lyase activity
CTK_RS08135	COG4303	Ethanolamine ammonia lyase large subunit
CTK_RS08140	COG0531	amino acid
CTK_RS08170	COG3706	GGDEF domain
CTK_RS08170	COG5001	Diguanylate cyclase
CTK_RS08170	COG2203	Gaf domain
CTK_RS08170	COG4251	negative regulation of phosphorylation
CTK_RS08210	COG1213	nucleotidyl transferase
CTK_RS08210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTK_RS08215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CTK_RS08225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTK_RS08260	COG0488	(ABC) transporter
CTK_RS08265	COG1362	aminopeptidase activity
CTK_RS08270	COG1464	Belongs to the NlpA lipoprotein family
CTK_RS08280	COG2011	ABC-type metal ion transport system permease component
CTK_RS08285	COG0598	Magnesium transport protein CorA
CTK_RS08290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CTK_RS08295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CTK_RS08305	COG3973	AAA domain
CTK_RS08320	COG0242	peptide deformylase activity
CTK_RS08325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTK_RS08345	COG2244	polysaccharide biosynthetic process
CTK_RS08350	COG2244	polysaccharide biosynthetic process
CTK_RS08360	COG1473	amidohydrolase
CTK_RS08365	COG0849	cell division
CTK_RS08375	COG1028	Short-chain dehydrogenase reductase Sdr
CTK_RS08385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CTK_RS08395	COG1686	Belongs to the peptidase S11 family
CTK_RS08400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CTK_RS08405	COG0840	transmembrane signaling receptor activity
CTK_RS08410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTK_RS08415	COG0824	Thioesterase
CTK_RS08425	COG0579	oxidoreductase
CTK_RS08430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CTK_RS08435	COG2155	Conserved Protein
CTK_RS08455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CTK_RS08460	COG2359	stage V sporulation protein S
CTK_RS08475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTK_RS08480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTK_RS08485	COG1674	ftsk spoiiie
CTK_RS08490	COG0740	serine-type endopeptidase activity
CTK_RS08495	COG0527	aspartate kinase activity
CTK_RS08505	COG0612	Peptidase, M16
CTK_RS08510	COG1185	polyribonucleotide nucleotidyltransferase activity
CTK_RS08515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CTK_RS08520	COG0196	riboflavin kinase activity
CTK_RS08525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTK_RS08540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CTK_RS08550	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CTK_RS08555	COG0195	Participates in both transcription termination and antitermination
CTK_RS08565	COG0765	amino acid transport
CTK_RS08570	COG0765	amino acid transport
CTK_RS08575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTK_RS08590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CTK_RS08595	COG0750	zinc metalloprotease
CTK_RS08600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CTK_RS08605	COG4589	Belongs to the CDS family
CTK_RS08615	COG0233	cytoplasmic translational termination
CTK_RS08625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CTK_RS08635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CTK_RS08640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTK_RS08645	COG0758	DNA mediated transformation
CTK_RS08650	COG0606	chelatase, subunit chli
CTK_RS08655	COG0792	nuclease activity
CTK_RS08660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTK_RS08665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTK_RS08670	COG0681	Belongs to the peptidase S26 family
CTK_RS08675	COG0335	large ribosomal subunit rRNA binding
CTK_RS08685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTK_RS08695	COG0228	four-way junction DNA binding
CTK_RS08700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTK_RS08705	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CTK_RS08710	COG0552	protein localization to endoplasmic reticulum
CTK_RS08725	COG0571	ribonuclease III activity
CTK_RS08730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTK_RS08735	COG0416	fatty acid biosynthetic process
CTK_RS08740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CTK_RS08750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTK_RS08755	COG0280	phosphate acetyltransferase
CTK_RS08760	COG1323	Belongs to the UPF0348 family
CTK_RS08775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CTK_RS08780	COG0742	ribosomal rna small subunit methyltransferase
CTK_RS08785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTK_RS08790	COG1461	Dihydroxyacetone kinase
CTK_RS08795	COG1302	Protein conserved in bacteria
CTK_RS08800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CTK_RS08810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTK_RS08815	COG1162	GTPase activity
CTK_RS08820	COG2815	serine threonine protein kinase
CTK_RS08820	COG0515	serine threonine protein kinase
CTK_RS08825	COG0631	protein serine/threonine phosphatase activity
CTK_RS08835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CTK_RS08835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTK_RS08840	COG2738	Putative neutral zinc metallopeptidase
CTK_RS08845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTK_RS08855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTK_RS08860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CTK_RS08865	COG1758	RNA polymerase activity
CTK_RS08870	COG0194	GDP metabolic process
CTK_RS08875	COG2052	Domain of unknown function (DUF370)
CTK_RS08880	COG1561	YicC-like family, N-terminal region
CTK_RS08885	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CTK_RS08895	COG1160	GTP binding
CTK_RS08905	COG0306	phosphate transporter
CTK_RS08910	COG1392	Phosphate transport regulator
CTK_RS08915	COG0704	Plays a role in the regulation of phosphate uptake
CTK_RS08920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CTK_RS08925	COG0581	inorganic phosphate transmembrane transporter activity
CTK_RS08930	COG0573	inorganic phosphate transmembrane transporter activity
CTK_RS08935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CTK_RS08940	COG5002	protein histidine kinase activity
CTK_RS08945	COG0745	RESPONSE REGULATOR receiver
CTK_RS08950	COG1496	oxidoreductase activity
CTK_RS08990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTK_RS08995	COG1873	PFAM PRC-barrel domain
CTK_RS09000	COG1191	sigma factor activity
CTK_RS09005	COG1191	sigma factor activity
CTK_RS09015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTK_RS09020	COG0849	cell division
CTK_RS09045	COG0826	peptidase U32
CTK_RS09050	COG4122	O-methyltransferase activity
CTK_RS09055	COG1217	gtp-binding protein TYPA
CTK_RS09065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CTK_RS09070	COG0735	belongs to the Fur family
CTK_RS09080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CTK_RS09085	COG4472	Bacterial protein of unknown function (DUF965)
CTK_RS09090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CTK_RS09105	COG1959	2 iron, 2 sulfur cluster binding
CTK_RS09110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CTK_RS09115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CTK_RS09125	COG0140	phosphoribosyl-ATP diphosphatase activity
CTK_RS09130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CTK_RS09150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CTK_RS09155	COG0131	Imidazoleglycerol-phosphate dehydratase
CTK_RS09160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CTK_RS09165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CTK_RS09170	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CTK_RS09185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTK_RS09195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CTK_RS09210	COG1937	Protein conserved in bacteria
CTK_RS09230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CTK_RS09235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CTK_RS09240	COG0517	IMP dehydrogenase activity
CTK_RS09240	COG0617	tRNA 3'-terminal CCA addition
CTK_RS09240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTK_RS09245	COG1686	Belongs to the peptidase S11 family
CTK_RS09250	COG4974	Belongs to the 'phage' integrase family
CTK_RS09340	COG4974	Belongs to the 'phage' integrase family
CTK_RS09350	COG0750	zinc metalloprotease
CTK_RS09355	COG0497	DNA recombination
CTK_RS09360	COG1438	arginine binding
CTK_RS09365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTK_RS09370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CTK_RS09375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTK_RS09385	COG1722	exodeoxyribonuclease VII activity
CTK_RS09390	COG1570	exodeoxyribonuclease VII activity
CTK_RS09395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTK_RS09440	COG3854	ATPases associated with a variety of cellular activities
CTK_RS09450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CTK_RS09455	COG0006	proline dipeptidase activity
CTK_RS09495	COG4969	Belongs to the N-Me-Phe pilin family
CTK_RS09500	COG1459	type II secretion system
CTK_RS09505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTK_RS09525	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CTK_RS09530	COG2233	PERMEase
CTK_RS09535	COG0708	Exodeoxyribonuclease III
CTK_RS09540	COG0564	pseudouridine synthase activity
CTK_RS09545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CTK_RS09550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CTK_RS09560	COG3599	regulation of cell shape
CTK_RS09565	COG2302	S4 RNA-binding domain
CTK_RS09580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CTK_RS09590	COG3856	small basic protein
CTK_RS09605	COG0772	Belongs to the SEDS family
CTK_RS09610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTK_RS09615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTK_RS09625	COG0768	penicillin binding
CTK_RS09635	COG0275	rRNA processing
CTK_RS09645	COG0012	GTP binding
CTK_RS09650	COG1067	ATP-dependent peptidase activity
CTK_RS09660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTK_RS09675	COG4786	Flagellar basal body rod
CTK_RS09685	COG4786	Flagellar basal body rod
CTK_RS09700	COG1191	sigma factor activity
CTK_RS09710	COG0455	bacterial-type flagellum organization
CTK_RS09715	COG1419	protein localization to endoplasmic reticulum
CTK_RS09720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTK_RS09725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTK_RS09735	COG1338	Plays a role in the flagellum-specific transport system
CTK_RS09750	COG1582	Flagellar protein (FlbD)
CTK_RS09755	COG4786	Flagellar basal body rod
CTK_RS09760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CTK_RS09775	COG1157	protein secretion by the type III secretion system
CTK_RS09785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTK_RS09790	COG1766	The M ring may be actively involved in energy transduction
CTK_RS09795	COG1677	Flagellar hook-basal body complex protein FliE
CTK_RS09800	COG1558	bacterial-type flagellum-dependent cell motility
CTK_RS09805	COG4786	Flagellar basal body rod
CTK_RS09810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTK_RS09820	COG0629	single-stranded DNA binding
CTK_RS09825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CTK_RS09840	COG0756	dUTP diphosphatase activity
CTK_RS09845	COG2223	nitrite transmembrane transporter activity
CTK_RS09850	COG2223	nitrite transmembrane transporter activity
CTK_RS09855	COG3279	Response regulator of the LytR AlgR family
CTK_RS09860	COG0840	transmembrane signaling receptor activity
CTK_RS09865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTK_RS09885	COG1131	(ABC) transporter
CTK_RS09895	COG5002	protein histidine kinase activity
CTK_RS09900	COG0745	RESPONSE REGULATOR receiver
CTK_RS09910	COG1263	PTS System
CTK_RS09910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CTK_RS09910	COG2190	(PTS) system
CTK_RS09915	COG3711	transcriptional antiterminator
CTK_RS09930	COG1331	Highly conserved protein containing a thioredoxin domain
CTK_RS09935	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CTK_RS09945	COG0784	Response regulator, receiver
CTK_RS09945	COG2205	protein histidine kinase activity
CTK_RS09945	COG5002	protein histidine kinase activity
CTK_RS09950	COG1388	LysM domain
CTK_RS09950	COG3584	3D domain protein
CTK_RS09955	COG0460	homoserine dehydrogenase
CTK_RS09960	COG0419	ATPase involved in DNA repair
CTK_RS09965	COG0420	3'-5' exonuclease activity
CTK_RS09970	COG0569	domain protein
CTK_RS09975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTK_RS09995	COG0432	Pfam Uncharacterised protein family UPF0047
CTK_RS10005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CTK_RS10015	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CTK_RS10035	COG0371	Dehydrogenase
CTK_RS10045	COG3775	system Galactitol-specific IIC component
CTK_RS10050	COG3414	Phosphotransferase system galactitol-specific IIB component
CTK_RS10060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CTK_RS10060	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CTK_RS10075	COG0439	Biotin carboxylase
CTK_RS10080	COG1116	anion transmembrane transporter activity
CTK_RS10085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS10095	COG0347	Belongs to the P(II) protein family
CTK_RS10125	COG2197	response regulator
CTK_RS10150	COG1070	Carbohydrate kinase
CTK_RS10200	COG4735	regulation of single-species biofilm formation
CTK_RS10285	COG0463	Glycosyl transferase, family 2
CTK_RS10300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CTK_RS10305	COG1516	flagellar protein fliS
CTK_RS10315	COG1334	flagellar protein FlaG
CTK_RS10320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CTK_RS10325	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CTK_RS10335	COG4786	Flagellar basal body rod
CTK_RS10335	COG1256	bacterial-type flagellum assembly
CTK_RS10350	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTK_RS10350	COG1776	CheC inhibitor of MCP methylation
CTK_RS10355	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTK_RS10360	COG0835	chemotaxis
CTK_RS10365	COG2201	protein-glutamate methylesterase activity
CTK_RS10370	COG1776	CheC inhibitor of MCP methylation
CTK_RS10375	COG2198	Histidine kinase
CTK_RS10375	COG0643	Histidine kinase
CTK_RS10380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CTK_RS10385	COG2201	protein-glutamate methylesterase activity
CTK_RS10405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTK_RS10420	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTK_RS10420	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTK_RS10420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTK_RS10420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTK_RS10430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTK_RS10435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTK_RS10435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTK_RS10440	COG0612	Peptidase, M16
CTK_RS10445	COG0693	protein deglycase activity
CTK_RS10460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CTK_RS10465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTK_RS10470	COG0187	DNA topoisomerase II activity
CTK_RS10475	COG1151	hydroxylamine reductase activity
CTK_RS10490	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CTK_RS10495	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CTK_RS10500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CTK_RS10510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTK_RS10515	COG4086	secreted protein
CTK_RS10525	COG0840	transmembrane signaling receptor activity
CTK_RS10545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CTK_RS10550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CTK_RS10555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CTK_RS10565	COG2084	Dehydrogenase
CTK_RS10575	COG0577	efflux transmembrane transporter activity
CTK_RS10580	COG0577	efflux transmembrane transporter activity
CTK_RS10585	COG1136	(ABC) transporter
CTK_RS10590	COG1321	iron dependent repressor
CTK_RS10595	COG1606	tRNA processing
CTK_RS10600	COG3773	Cell wall hydrolase
CTK_RS10625	COG0436	Aminotransferase
CTK_RS10650	COG4221	oxidoreductase activity
CTK_RS10660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CTK_RS10665	COG0321	lipoyl(octanoyl) transferase activity
CTK_RS10670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CTK_RS10690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTK_RS10695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTK_RS10720	COG2340	Cysteine-rich secretory protein family
CTK_RS10730	COG0183	Belongs to the thiolase family
CTK_RS10735	COG1268	BioY protein
CTK_RS10745	COG0371	Dehydrogenase
CTK_RS10755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTK_RS10760	COG0586	Pfam SNARE associated Golgi protein
CTK_RS10765	COG0617	tRNA 3'-terminal CCA addition
CTK_RS10780	COG0426	domain, Protein
CTK_RS10780	COG1773	rubredoxin
CTK_RS10800	COG0463	Glycosyl transferase, family 2
CTK_RS10840	COG0697	spore germination
CTK_RS10855	COG0583	DNA-binding transcription factor activity
CTK_RS10865	COG4185	zeta toxin
CTK_RS10885	COG2894	cell division
CTK_RS10905	COG1342	Belongs to the UPF0251 family
CTK_RS10940	COG2946	Replication initiation factor
CTK_RS11005	COG1674	ftsk spoiiie
CTK_RS11020	COG1234	tRNA 3'-trailer cleavage
CTK_RS11030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTK_RS11050	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTK_RS11150	COG0740	serine-type endopeptidase activity
CTK_RS11160	COG4626	Terminase
CTK_RS11160	COG1802	Transcriptional regulator
CTK_RS11230	COG3617	BRO family, N-terminal domain
CTK_RS11235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTK_RS11235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTK_RS11315	COG1368	sulfuric ester hydrolase activity
CTK_RS11325	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CTK_RS11330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTK_RS11330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTK_RS11360	COG3775	system Galactitol-specific IIC component
CTK_RS11370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTK_RS11370	COG3711	transcriptional antiterminator
CTK_RS11385	COG0149	triose-phosphate isomerase activity
CTK_RS11395	COG0698	ribose 5-phosphate isomerase
CTK_RS11400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CTK_RS11405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CTK_RS11410	COG1349	DNA-binding transcription factor activity
CTK_RS11420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTK_RS11430	COG5434	Belongs to the glycosyl hydrolase 28 family
CTK_RS11430	COG4632	Exopolysaccharide biosynthesis protein
CTK_RS11435	COG0151	Belongs to the GarS family
CTK_RS11440	COG0138	bifunctional purine biosynthesis protein purh
CTK_RS11445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTK_RS11450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CTK_RS11455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CTK_RS11460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CTK_RS11465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CTK_RS11480	COG2252	PERMEase
CTK_RS11490	COG1408	metallophosphoesterase
CTK_RS11495	COG0534	Mate efflux family protein
CTK_RS11500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTK_RS11505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CTK_RS11515	COG1396	sequence-specific DNA binding
CTK_RS11530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CTK_RS11545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTK_RS11550	COG0358	DNA primase activity
CTK_RS11565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTK_RS11565	COG0574	Belongs to the PEP-utilizing enzyme family
CTK_RS11570	COG0517	IMP dehydrogenase activity
CTK_RS11580	COG1381	Involved in DNA repair and RecF pathway recombination
CTK_RS11585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTK_RS11600	COG1480	7TM receptor with intracellular HD hydrolase
CTK_RS11620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CTK_RS11625	COG0537	adenosine 5'-monophosphoramidase activity
CTK_RS11630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTK_RS11635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CTK_RS11645	COG0484	heat shock protein binding
CTK_RS11650	COG0443	Heat shock 70 kDa protein
CTK_RS11655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CTK_RS11660	COG1420	regulation of RNA biosynthetic process
CTK_RS11665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTK_RS11670	COG0481	GTPase activity
CTK_RS11690	COG1466	dna polymerase III delta subunit
CTK_RS11705	COG2183	response to ionizing radiation
CTK_RS11710	COG1686	Belongs to the peptidase S11 family
CTK_RS11715	COG0564	pseudouridine synthase activity
CTK_RS11720	COG0251	oxidation-reduction process
CTK_RS11725	COG1713	HD superfamily hydrolase involved in NAD metabolism
CTK_RS11730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CTK_RS11740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CTK_RS11755	COG1530	ribonuclease E activity
CTK_RS11770	COG1994	Peptidase M50
CTK_RS11780	COG1803	Methylglyoxal synthase
CTK_RS11785	COG0772	Belongs to the SEDS family
CTK_RS11795	COG2894	cell division
CTK_RS11810	COG3409	Peptidoglycan-binding domain 1 protein
CTK_RS11830	COG0768	penicillin binding
CTK_RS11845	COG1077	Cell shape determining protein MreB Mrl
CTK_RS11850	COG2003	Belongs to the UPF0758 family
CTK_RS11855	COG0424	maF-like protein
CTK_RS11870	COG0083	homoserine kinase activity
CTK_RS11875	COG0460	homoserine dehydrogenase
CTK_RS11880	COG4492	Belongs to the UPF0735 family
CTK_RS11885	COG0531	amino acid
CTK_RS11915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTK_RS11915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTK_RS11955	COG2814	Major facilitator Superfamily
CTK_RS11970	COG0285	dihydrofolate synthase activity
CTK_RS11975	COG0525	valine-tRNA ligase activity
CTK_RS11980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTK_RS11990	COG0431	NADPH-dependent FMN reductase
CTK_RS12020	COG1522	sequence-specific DNA binding
CTK_RS12025	COG1522	sequence-specific DNA binding
CTK_RS12030	COG0535	radical SAM domain protein
CTK_RS12035	COG0535	radical SAM domain protein
CTK_RS12040	COG1725	Transcriptional regulator
CTK_RS12065	COG2199	diguanylate cyclase activity
CTK_RS12065	COG2203	Gaf domain
CTK_RS12070	COG0861	Integral membrane protein TerC family
CTK_RS12085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTK_RS12150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CTK_RS12155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTK_RS12160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CTK_RS12165	COG0436	Aminotransferase
CTK_RS12195	COG2171	N-acyltransferase activity
CTK_RS12255	COG1116	anion transmembrane transporter activity
CTK_RS12260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTK_RS12280	COG0612	Peptidase, M16
CTK_RS12285	COG0513	Belongs to the DEAD box helicase family
CTK_RS12295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTK_RS12310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTK_RS12325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CTK_RS12340	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CTK_RS12345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CTK_RS12355	COG0735	belongs to the Fur family
CTK_RS12380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CTK_RS12385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTK_RS12390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CTK_RS12420	COG0167	dihydroorotate dehydrogenase activity
CTK_RS12425	COG0543	2 iron, 2 sulfur cluster binding
CTK_RS12430	COG0284	orotidine-5'-phosphate decarboxylase activity
CTK_RS12440	COG0540	Belongs to the ATCase OTCase family
CTK_RS12455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CTK_RS12480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CTK_RS12490	COG1177	transmembrane transport
CTK_RS12495	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTK_RS12500	COG3842	ATPase activity
CTK_RS12505	COG0347	Belongs to the P(II) protein family
CTK_RS12510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CTK_RS12530	COG2423	ornithine cyclodeaminase activity
CTK_RS12535	COG4978	Transcriptional regulator
CTK_RS12535	COG0789	Transcriptional regulator
CTK_RS12545	COG1979	alcohol dehydrogenase
CTK_RS12550	COG0582	viral genome integration into host DNA
CTK_RS12635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CTK_RS12650	COG4166	transmembrane transport
CTK_RS12675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTK_RS12685	COG4496	protein, YerC YecD
CTK_RS12690	COG1187	pseudouridine synthase activity
CTK_RS12695	COG0741	lytic transglycosylase activity
CTK_RS12710	COG0166	Belongs to the GPI family
CTK_RS12720	COG1960	acyl-CoA dehydrogenase activity
CTK_RS12725	COG0277	FAD linked oxidase domain protein
CTK_RS12730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTK_RS12735	COG2086	electron transfer activity
CTK_RS12740	COG0519	Catalyzes the synthesis of GMP from XMP
CTK_RS12745	COG0516	GMP reductase activity
CTK_RS12745	COG0517	IMP dehydrogenase activity
CTK_RS12750	COG0459	protein refolding
CTK_RS12755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CTK_RS12760	COG0586	Pfam SNARE associated Golgi protein
CTK_RS12780	COG0493	'glutamate synthase
CTK_RS12780	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTK_RS12790	COG1250	3-hydroxyacyl-CoA dehydrogenase
CTK_RS12795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTK_RS12800	COG2086	electron transfer activity
CTK_RS12805	COG1960	acyl-CoA dehydrogenase activity
CTK_RS12810	COG1024	Enoyl-CoA hydratase
CTK_RS12815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CTK_RS12820	COG0488	(ABC) transporter
CTK_RS12830	COG3279	Response regulator of the LytR AlgR family
CTK_RS12840	COG1966	Carbon starvation protein
CTK_RS12855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CTK_RS12860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CTK_RS12880	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTK_RS12890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CTK_RS12895	COG3404	Formiminotransferase-cyclodeaminase
CTK_RS12900	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CTK_RS12915	COG0456	acetyltransferase
CTK_RS12920	COG1214	PFAM Peptidase M22, glycoprotease
CTK_RS12925	COG0802	atpase or kinase
CTK_RS12930	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTK_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
CTK_RS13000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTK_RS13025	COG2814	Major facilitator Superfamily
CTK_RS13030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CTK_RS13035	COG0561	phosphatase activity
CTK_RS13045	COG2033	superoxide reductase activity
CTK_RS13050	COG3459	Glycosyltransferase 36 associated
CTK_RS13055	COG0019	diaminopimelate decarboxylase activity
CTK_RS13065	COG1362	aminopeptidase activity
CTK_RS13070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTK_RS13075	COG3973	AAA domain
CTK_RS13080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTK_RS13085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CTK_RS13100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTK_RS13105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTK_RS13110	COG0473	3-isopropylmalate dehydrogenase activity
CTK_RS13115	COG0066	3-isopropylmalate dehydratase activity
CTK_RS13120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTK_RS13125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTK_RS13130	COG0531	amino acid
CTK_RS13135	COG1605	Chorismate mutase
CTK_RS13135	COG0077	Prephenate dehydratase
CTK_RS13140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CTK_RS13145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTK_RS13150	COG0287	Prephenate dehydrogenase
CTK_RS13155	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTK_RS13165	COG1970	mechanosensitive ion channel activity
CTK_RS13170	COG4948	Mandelate Racemase Muconate Lactonizing
CTK_RS13180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTK_RS13185	COG3842	ATPase activity
CTK_RS13190	COG0584	glycerophosphoryl diester phosphodiesterase
CTK_RS13235	COG0116	Belongs to the methyltransferase superfamily
CTK_RS13245	COG0521	Mo-molybdopterin cofactor biosynthetic process
CTK_RS13255	COG0561	phosphatase activity
CTK_RS13270	COG1301	dicarboxylic acid transport
CTK_RS13280	COG2719	SpoVR family
CTK_RS13285	COG2718	Belongs to the UPF0229 family
CTK_RS13290	COG2766	serine protein kinase
CTK_RS13300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CTK_RS13310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CTK_RS13315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CTK_RS13325	COG0531	amino acid
CTK_RS13330	COG0531	amino acid
CTK_RS13335	COG2267	carboxylic ester hydrolase activity
CTK_RS13340	COG1175	transmembrane transport
CTK_RS13345	COG0395	ABC-type sugar transport system, permease component
CTK_RS13350	COG1653	transport
CTK_RS13370	COG1113	amino acid transport
CTK_RS13375	COG0730	response to heat
CTK_RS13400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CTK_RS13415	COG0469	pyruvate kinase activity
CTK_RS13435	COG4109	DRTGG domain
CTK_RS13445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CTK_RS13450	COG1660	Displays ATPase and GTPase activities
CTK_RS13455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CTK_RS13460	COG0322	excinuclease ABC activity
CTK_RS13470	COG0768	penicillin binding
CTK_RS13495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTK_RS13500	COG3409	Peptidoglycan-binding domain 1 protein
CTK_RS13500	COG0793	Belongs to the peptidase S41A family
CTK_RS13505	COG2177	Part of the ABC transporter FtsEX involved in
CTK_RS13510	COG2884	Cell division ATP-binding protein ftsE
CTK_RS13525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTK_RS13535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CTK_RS13535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CTK_RS13540	COG0736	holo-[acyl-carrier-protein] synthase activity
CTK_RS13550	COG2190	(PTS) system
CTK_RS13555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTK_RS13570	COG1773	rubredoxin
CTK_RS13570	COG1592	Rubrerythrin
CTK_RS13575	COG1482	cell wall glycoprotein biosynthetic process
CTK_RS13580	COG0840	transmembrane signaling receptor activity
CTK_RS13585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CTK_RS13590	COG5002	protein histidine kinase activity
CTK_RS13595	COG0745	RESPONSE REGULATOR receiver
CTK_RS13600	COG0463	Glycosyl transferase, family 2
CTK_RS13610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CTK_RS13615	COG1960	acyl-CoA dehydrogenase activity
CTK_RS13620	COG4670	ketone body catabolic process
CTK_RS13625	COG1024	Enoyl-CoA hydratase
CTK_RS13630	COG2610	gluconate transmembrane transporter activity
CTK_RS13635	COG1846	Transcriptional regulator
CTK_RS13640	COG1349	DNA-binding transcription factor activity
CTK_RS13660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CTK_RS13675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTK_RS13685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CTK_RS13695	COG1846	Transcriptional regulator
CTK_RS13695	COG1940	carbohydrate kinase activity
CTK_RS13700	COG0406	alpha-ribazole phosphatase activity
CTK_RS13705	COG0671	phosphoesterase, PA-phosphatase related
CTK_RS13710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CTK_RS13715	COG2508	Transcriptional regulator
CTK_RS13720	COG1177	transmembrane transport
CTK_RS13725	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTK_RS13745	COG0789	Transcriptional regulator
CTK_RS13745	COG4978	Transcriptional regulator
CTK_RS13750	COG1151	hydroxylamine reductase activity
CTK_RS13765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTK_RS13770	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CTK_RS13780	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CTK_RS13790	COG0492	ferredoxin-NADP+ reductase activity
CTK_RS13795	COG3118	belongs to the thioredoxin family
CTK_RS13805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTK_RS13810	COG3829	transcription factor binding
CTK_RS13810	COG3290	protein histidine kinase activity
CTK_RS13840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTK_RS13845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTK_RS13850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CTK_RS13855	COG0101	tRNA pseudouridine synthase activity
CTK_RS13860	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CTK_RS13880	COG0202	RNA polymerase activity
CTK_RS13895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CTK_RS13900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CTK_RS13915	COG0563	adenylate kinase activity
CTK_RS13920	COG0201	protein transport
CTK_RS13925	COG0200	Binds to the 23S rRNA
CTK_RS13930	COG1841	ribosomal large subunit assembly
CTK_RS13935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CTK_RS13940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CTK_RS13945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CTK_RS13950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CTK_RS13955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CTK_RS13960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CTK_RS13970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CTK_RS13975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CTK_RS13980	COG0255	Belongs to the universal ribosomal protein uL29 family
CTK_RS13985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CTK_RS13990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CTK_RS13995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CTK_RS14000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CTK_RS14015	COG0088	Forms part of the polypeptide exit tunnel
CTK_RS14020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CTK_RS14025	COG0051	transcription antitermination factor activity, RNA binding
CTK_RS14030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTK_RS14035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTK_RS14045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CTK_RS14050	COG1358	cellular component organization or biogenesis
CTK_RS14055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CTK_RS14060	COG0085	RNA polymerase activity
CTK_RS14075	COG0081	regulation of translation
CTK_RS14095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CTK_RS14100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTK_RS14125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTK_RS14140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CTK_RS14145	COG4956	integral membrane protein (PIN domain superfamily)
CTK_RS14155	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CTK_RS14160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTK_RS14165	COG0542	response to heat
CTK_RS14170	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CTK_RS14175	COG3880	PFAM UvrB UvrC protein
CTK_RS14265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CTK_RS14270	COG0423	glycine-tRNA ligase activity
CTK_RS14275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTK_RS14290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTK_RS14295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CTK_RS14305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTK_RS14310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CTK_RS14320	COG2208	phosphoserine phosphatase activity
CTK_RS14350	COG1098	S1 RNA binding domain
CTK_RS14370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CTK_RS14380	COG3956	TIGRFAM MazG family protein
CTK_RS14385	COG2244	polysaccharide biosynthetic process
CTK_RS14390	COG2002	toxin-antitoxin pair type II binding
CTK_RS14395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTK_RS14400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTK_RS14410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTK_RS14415	COG3850	Histidine kinase
CTK_RS14415	COG5002	protein histidine kinase activity
CTK_RS14420	COG0745	RESPONSE REGULATOR receiver
CTK_RS14430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CTK_RS14435	COG2088	sporulation resulting in formation of a cellular spore
CTK_RS14440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTK_RS14445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTK_RS14460	COG0310	cobalt ion transport
CTK_RS14475	COG1122	ATPase activity
CTK_RS14480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTK_RS14485	COG2045	Belongs to the ComB family
CTK_RS14490	COG1242	4 iron, 4 sulfur cluster binding
CTK_RS14500	COG3949	Membrane
CTK_RS14510	COG0840	transmembrane signaling receptor activity
CTK_RS14525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTK_RS14545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CTK_RS14560	COG0653	protein targeting
CTK_RS14565	COG0017	Asparaginyl-tRNA synthetase
CTK_RS14585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTK_RS14590	COG0366	Alpha amylase catalytic
CTK_RS14590	COG3103	Sh3 type 3 domain protein
CTK_RS14595	COG0058	SHG alpha-glucan phosphorylase activity
CTK_RS14600	COG0297	glycogen (starch) synthase activity
CTK_RS14615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTK_RS14630	COG1404	Belongs to the peptidase S8 family
CTK_RS14640	COG0825	malonyl-CoA metabolic process
CTK_RS14645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CTK_RS14650	COG0439	Biotin carboxylase
CTK_RS14655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CTK_RS14660	COG0511	ligase activity, forming carbon-carbon bonds
CTK_RS14665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTK_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
CTK_RS14675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTK_RS14680	COG2070	2-Nitropropane dioxygenase
CTK_RS14685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTK_RS14755	COG2081	HI0933 family
CTK_RS14770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTK_RS14775	COG0492	ferredoxin-NADP+ reductase activity
CTK_RS14810	COG0347	Belongs to the P(II) protein family
CTK_RS14815	COG0347	Belongs to the P(II) protein family
CTK_RS14820	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CTK_RS14825	COG1910	domain protein
CTK_RS14840	COG1696	Membrane protein involved in D-alanine export
CTK_RS14850	COG2814	Major facilitator Superfamily
CTK_RS14855	COG1846	Transcriptional regulator
CTK_RS14865	COG0582	viral genome integration into host DNA
CTK_RS14875	COG0071	Belongs to the small heat shock protein (HSP20) family
CTK_RS14880	COG0305	Participates in initiation and elongation during chromosome replication
CTK_RS14885	COG1067	ATP-dependent peptidase activity
CTK_RS14885	COG0470	DNA polymerase III
CTK_RS14890	COG0359	binds to the 23S rRNA
CTK_RS14895	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CTK_RS14910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CTK_RS14930	COG0668	transmembrane transport
CTK_RS14940	COG0628	permease
CTK_RS14960	COG1475	DNA binding
CTK_RS14965	COG1192	Involved in chromosome partitioning
CTK_RS14975	COG0357	Ribosomal RNA small subunit methyltransferase G
CTK_RS14980	COG0445	tRNA wobble uridine modification
CTK_RS14985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTK_RS14990	COG1847	R3H domain protein
CTK_RS15000	COG0594	ribonuclease P activity
CTK_RS15035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTK_RS15170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTK_RS15180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CTK_RS15225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family