locus-tag	class	description
B5808_RS00010	COG0592	DNA-directed DNA polymerase activity
B5808_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B5808_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5808_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B5808_RS00030	COG0187	DNA topoisomerase II activity
B5808_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5808_RS00085	COG3764	Sortase (surface protein transpeptidase)
B5808_RS00095	COG2815	serine threonine protein kinase
B5808_RS00095	COG0515	serine threonine protein kinase
B5808_RS00100	COG0515	serine threonine protein kinase
B5808_RS00105	COG0768	penicillin binding
B5808_RS00120	COG1716	ATPase activity
B5808_RS00125	COG1716	ATPase activity
B5808_RS00130	COG1832	CoA-binding protein
B5808_RS00170	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B5808_RS00175	COG0738	Major facilitator superfamily
B5808_RS00180	COG1609	Transcriptional regulator
B5808_RS00185	COG0477	Major facilitator Superfamily
B5808_RS00195	COG0534	Mate efflux family protein
B5808_RS00205	COG3590	peptidase
B5808_RS00220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5808_RS00265	COG1175	transmembrane transport
B5808_RS00270	COG0395	ABC-type sugar transport system, permease component
B5808_RS00275	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
B5808_RS00290	COG1132	(ABC) transporter
B5808_RS00290	COG2375	cellular response to nickel ion
B5808_RS00295	COG1120	ATPase activity
B5808_RS00300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5808_RS00305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5808_RS00310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5808_RS00325	COG1414	Transcriptional regulator
B5808_RS00330	COG3588	fructose-bisphosphate aldolase
B5808_RS00340	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS00345	COG0180	Tryptophanyl-tRNA synthetase
B5808_RS00375	COG1653	transport
B5808_RS00385	COG0395	ABC-type sugar transport system, permease component
B5808_RS00415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B5808_RS00425	COG4585	Histidine kinase
B5808_RS00430	COG2814	Major facilitator Superfamily
B5808_RS00460	COG2207	Transcriptional regulator
B5808_RS00490	COG2015	COG2015, Alkyl sulfatase and related hydrolases
B5808_RS00500	COG1733	regulation of RNA biosynthetic process
B5808_RS00505	COG0604	alcohol dehydrogenase
B5808_RS00535	COG0667	Aldo Keto reductase
B5808_RS00545	COG1472	Belongs to the glycosyl hydrolase 3 family
B5808_RS00570	COG2197	response regulator
B5808_RS00570	COG3903	Transcriptional regulator
B5808_RS00585	COG0277	FAD linked oxidase domain protein
B5808_RS00635	COG1522	sequence-specific DNA binding
B5808_RS00640	COG4166	transmembrane transport
B5808_RS00645	COG0601	transmembrane transport
B5808_RS00650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5808_RS00665	COG0006	proline dipeptidase activity
B5808_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS00715	COG1063	alcohol dehydrogenase
B5808_RS00725	COG2140	Oxalate decarboxylase
B5808_RS00730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5808_RS00735	COG1737	Transcriptional regulator
B5808_RS00745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B5808_RS00760	COG3959	Transketolase, thiamine diphosphate binding domain
B5808_RS00765	COG3958	Transketolase
B5808_RS00780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B5808_RS00810	COG0438	transferase activity, transferring glycosyl groups
B5808_RS00820	COG1216	Glycosyl transferase, family 2
B5808_RS00845	COG3546	catalase activity
B5808_RS00885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS00900	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS00910	COG4335	DNA alkylation repair
B5808_RS00920	COG3971	2-oxopent-4-enoate hydratase activity
B5808_RS00955	COG0667	Aldo Keto reductase
B5808_RS00960	COG1733	regulation of RNA biosynthetic process
B5808_RS00980	COG1454	alcohol dehydrogenase
B5808_RS01000	COG3246	L-lysine catabolic process to acetate
B5808_RS01015	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5808_RS01025	COG3842	ATPase activity
B5808_RS01050	COG0477	Major facilitator Superfamily
B5808_RS01075	COG2326	polyphosphate kinase activity
B5808_RS01120	COG1793	dna ligase
B5808_RS01175	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B5808_RS01185	COG5001	Diguanylate cyclase
B5808_RS01185	COG3300	MHYT domain
B5808_RS01190	COG2267	carboxylic ester hydrolase activity
B5808_RS01200	COG0477	Major facilitator Superfamily
B5808_RS01215	COG1653	transport
B5808_RS01225	COG0395	ABC-type sugar transport system, permease component
B5808_RS01235	COG0366	Alpha amylase catalytic
B5808_RS01240	COG0577	efflux transmembrane transporter activity
B5808_RS01245	COG1136	(ABC) transporter
B5808_RS01245	COG0577	efflux transmembrane transporter activity
B5808_RS01260	COG0494	nUDIX hydrolase
B5808_RS01265	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B5808_RS01270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5808_RS01275	COG1233	COG1233 Phytoene dehydrogenase and related
B5808_RS01290	COG0673	inositol 2-dehydrogenase activity
B5808_RS01310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B5808_RS01330	COG3253	May function as heme-dependent peroxidase
B5808_RS01335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B5808_RS01340	COG0181	hydroxymethylbilane synthase activity
B5808_RS01360	COG1129	ABC transporter
B5808_RS01365	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS01375	COG0457	Tetratricopeptide repeat
B5808_RS01380	COG2017	converts alpha-aldose to the beta-anomer
B5808_RS01385	COG0477	Major facilitator Superfamily
B5808_RS01420	COG0113	porphobilinogen synthase activity
B5808_RS01425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5808_RS01440	COG0604	alcohol dehydrogenase
B5808_RS01475	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B5808_RS01485	COG1054	Belongs to the UPF0176 family
B5808_RS01515	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS01520	COG1725	Transcriptional regulator
B5808_RS01530	COG1834	amidinotransferase
B5808_RS01535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5808_RS01570	COG4552	Acetyltransferase involved in intracellular survival and related
B5808_RS01615	COG1305	Transglutaminase-like
B5808_RS01625	COG1278	Cold shock
B5808_RS01655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS01675	COG1063	alcohol dehydrogenase
B5808_RS01685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5808_RS01690	COG1609	Transcriptional regulator
B5808_RS01725	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5808_RS01755	COG2076	Multidrug Resistance protein
B5808_RS01765	COG4977	sequence-specific DNA binding
B5808_RS01775	COG3483	tryptophan 2,3-dioxygenase activity
B5808_RS01815	COG3046	protein related to deoxyribodipyrimidine photolyase
B5808_RS01820	COG1302	Protein conserved in bacteria
B5808_RS01845	COG3237	CsbD-like
B5808_RS01880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5808_RS01890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5808_RS01895	COG1850	ribulose-bisphosphate carboxylase activity
B5808_RS01915	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS01920	COG1129	ABC transporter
B5808_RS01925	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS01935	COG2186	Transcriptional regulator
B5808_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS01955	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B5808_RS01965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5808_RS01985	COG1414	Transcriptional regulator
B5808_RS01995	COG0800	Aldolase
B5808_RS02005	COG1609	Transcriptional regulator
B5808_RS02010	COG1063	alcohol dehydrogenase
B5808_RS02020	COG1366	Belongs to the anti-sigma-factor antagonist family
B5808_RS02025	COG1215	transferase activity, transferring glycosyl groups
B5808_RS02060	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5808_RS02065	COG0596	Alpha beta hydrolase
B5808_RS02065	COG2945	thiolester hydrolase activity
B5808_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS02090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5808_RS02100	COG1744	ABC transporter substrate-binding protein PnrA-like
B5808_RS02105	COG3845	ABC transporter
B5808_RS02110	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5808_RS02115	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5808_RS02120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5808_RS02140	COG2197	response regulator
B5808_RS02185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5808_RS02200	COG0477	Major facilitator Superfamily
B5808_RS02205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B5808_RS02220	COG1414	Transcriptional regulator
B5808_RS02225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5808_RS02235	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5808_RS02240	COG0277	FAD linked oxidase domain protein
B5808_RS02290	COG0657	acetylesterase activity
B5808_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS02310	COG0300	oxidoreductase activity
B5808_RS02315	COG1960	acyl-CoA dehydrogenase activity
B5808_RS02330	COG0395	ABC-type sugar transport system, permease component
B5808_RS02345	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS02355	COG1136	(ABC) transporter
B5808_RS02360	COG1136	(ABC) transporter
B5808_RS02360	COG0577	efflux transmembrane transporter activity
B5808_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS02410	COG0277	FAD linked oxidase domain protein
B5808_RS02415	COG1070	Carbohydrate kinase
B5808_RS02420	COG1174	glycine betaine transport
B5808_RS02425	COG0517	IMP dehydrogenase activity
B5808_RS02425	COG1125	glycine betaine transport
B5808_RS02430	COG1174	glycine betaine transport
B5808_RS02450	COG1819	glycosyl
B5808_RS02455	COG4948	Mandelate Racemase Muconate Lactonizing
B5808_RS02470	COG4209	transmembrane transport
B5808_RS02485	COG3250	beta-galactosidase activity
B5808_RS02505	COG0667	Aldo Keto reductase
B5808_RS02525	COG1595	DNA-templated transcription, initiation
B5808_RS02540	COG1136	(ABC) transporter
B5808_RS02555	COG3290	protein histidine kinase activity
B5808_RS02580	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B5808_RS02605	COG0477	Major facilitator Superfamily
B5808_RS02610	COG1309	transcriptional regulator
B5808_RS02620	COG0740	serine-type endopeptidase activity
B5808_RS02655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5808_RS02660	COG0601	transmembrane transport
B5808_RS02730	COG1674	ftsk spoiiie
B5808_RS02750	COG0631	protein serine/threonine phosphatase activity
B5808_RS02770	COG0714	Associated with various cellular activities
B5808_RS02780	COG1876	peptidase activity
B5808_RS02795	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B5808_RS02800	COG1070	Carbohydrate kinase
B5808_RS02805	COG2115	Belongs to the xylose isomerase family
B5808_RS02810	COG4213	ABC transporter substrate-binding protein
B5808_RS02815	COG1129	ABC transporter
B5808_RS02820	COG4214	carbohydrate transport
B5808_RS02825	COG1940	carbohydrate kinase activity
B5808_RS02835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B5808_RS02845	COG0183	Belongs to the thiolase family
B5808_RS02855	COG1653	transport
B5808_RS02860	COG1175	transmembrane transport
B5808_RS02865	COG0395	ABC-type sugar transport system, permease component
B5808_RS02870	COG3622	Belongs to the hyi family
B5808_RS02940	COG1846	Transcriptional regulator
B5808_RS02940	COG1940	carbohydrate kinase activity
B5808_RS02945	COG0673	inositol 2-dehydrogenase activity
B5808_RS02970	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5808_RS02975	COG1506	peptidase
B5808_RS02975	COG0823	Involved in the tonB-independent uptake of proteins
B5808_RS02980	COG2814	Major facilitator Superfamily
B5808_RS03005	COG1414	Transcriptional regulator
B5808_RS03010	COG3485	protocatechuate 3,4-dioxygenase
B5808_RS03015	COG3485	protocatechuate 3,4-dioxygenase
B5808_RS03025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B5808_RS03065	COG4221	oxidoreductase activity
B5808_RS03070	COG0033	Phosphoglucomutase
B5808_RS03075	COG0077	Prephenate dehydratase
B5808_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS03085	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5808_RS03090	COG2186	Transcriptional regulator
B5808_RS03095	COG1309	transcriptional regulator
B5808_RS03100	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS03105	COG1733	regulation of RNA biosynthetic process
B5808_RS03110	COG0431	NADPH-dependent FMN reductase
B5808_RS03125	COG1597	lipid kinase activity
B5808_RS03130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B5808_RS03160	COG0726	polysaccharide deacetylase
B5808_RS03175	COG1316	TRANSCRIPTIONal
B5808_RS03180	COG1316	TRANSCRIPTIONal
B5808_RS03190	COG2733	membrane
B5808_RS03220	COG3609	addiction module antidote protein, CC2985 family
B5808_RS03230	COG1309	transcriptional regulator
B5808_RS03235	COG0667	Aldo Keto reductase
B5808_RS03245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5808_RS03260	COG0024	Methionine aminopeptidase
B5808_RS03275	COG1802	Transcriptional regulator
B5808_RS03280	COG2079	MmgE PrpD family protein
B5808_RS03285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B5808_RS03310	COG0406	alpha-ribazole phosphatase activity
B5808_RS03315	COG0328	RNA-DNA hybrid ribonuclease activity
B5808_RS03360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5808_RS03370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5808_RS03380	COG1609	Transcriptional regulator
B5808_RS03385	COG0745	RESPONSE REGULATOR receiver
B5808_RS03390	COG0477	Major facilitator Superfamily
B5808_RS03395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B5808_RS03405	COG0519	Catalyzes the synthesis of GMP from XMP
B5808_RS03405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5808_RS03415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B5808_RS03420	COG0569	domain protein
B5808_RS03425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5808_RS03430	COG0640	Transcriptional regulator
B5808_RS03470	COG0017	Asparaginyl-tRNA synthetase
B5808_RS03475	COG5006	permease, DMT superfamily
B5808_RS03485	COG0406	alpha-ribazole phosphatase activity
B5808_RS03490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5808_RS03495	COG0785	Cytochrome C biogenesis protein
B5808_RS03520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5808_RS03525	COG4948	Mandelate Racemase Muconate Lactonizing
B5808_RS03530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B5808_RS03555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B5808_RS03560	COG0514	ATP-dependent DNA helicase (RecQ)
B5808_RS03565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B5808_RS03565	COG2308	Evidence 4 Homologs of previously reported genes of
B5808_RS03580	COG0318	PFAM AMP-dependent synthetase and ligase
B5808_RS03580	COG0204	Acyl-transferase
B5808_RS03600	COG1131	(ABC) transporter
B5808_RS03610	COG4585	Histidine kinase
B5808_RS03615	COG2197	response regulator
B5808_RS03725	COG1744	ABC transporter substrate-binding protein PnrA-like
B5808_RS03730	COG3845	ABC transporter
B5808_RS03745	COG1335	isochorismatase
B5808_RS03760	COG4821	SIS domain
B5808_RS03765	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS03770	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS03775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5808_RS03780	COG1960	acyl-CoA dehydrogenase activity
B5808_RS03795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B5808_RS03800	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
B5808_RS03805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B5808_RS03805	COG0235	Class ii aldolase
B5808_RS03815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5808_RS03820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B5808_RS03825	COG1695	Transcriptional regulator
B5808_RS03860	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B5808_RS03885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B5808_RS03885	COG1796	DNA polymerase
B5808_RS03890	COG0406	alpha-ribazole phosphatase activity
B5808_RS03910	COG1396	sequence-specific DNA binding
B5808_RS03935	COG2197	response regulator
B5808_RS03940	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS03950	COG2326	polyphosphate kinase activity
B5808_RS03970	COG1846	Transcriptional regulator
B5808_RS03980	COG0300	oxidoreductase activity
B5808_RS04015	COG1785	Belongs to the alkaline phosphatase family
B5808_RS04045	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B5808_RS04050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B5808_RS04055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B5808_RS04080	COG1573	uracil-dna glycosylase
B5808_RS04090	COG2135	peptidase activity
B5808_RS04105	COG0492	ferredoxin-NADP+ reductase activity
B5808_RS04125	COG0741	lytic transglycosylase activity
B5808_RS04125	COG0739	heme binding
B5808_RS04125	COG1196	nuclear chromosome segregation
B5808_RS04130	COG1196	nuclear chromosome segregation
B5808_RS04130	COG0739	heme binding
B5808_RS04130	COG0741	lytic transglycosylase activity
B5808_RS04145	COG0037	tRNA processing
B5808_RS04150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B5808_RS04155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5808_RS04160	COG0302	gtp cyclohydrolase
B5808_RS04170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B5808_RS04175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5808_RS04205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B5808_RS04210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B5808_RS04225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5808_RS04245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B5808_RS04295	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS04305	COG1051	belongs to the nudix hydrolase family
B5808_RS04320	COG2272	Belongs to the type-B carboxylesterase lipase family
B5808_RS04325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B5808_RS04340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B5808_RS04345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5808_RS04355	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B5808_RS04360	COG0352	thiamine-phosphate diphosphorylase activity
B5808_RS04365	COG0351	phosphomethylpyrimidine kinase
B5808_RS04365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B5808_RS04365	COG0352	thiamine-phosphate diphosphorylase activity
B5808_RS04370	COG1215	transferase activity, transferring glycosyl groups
B5808_RS04395	COG1175	transmembrane transport
B5808_RS04400	COG0395	ABC-type sugar transport system, permease component
B5808_RS04410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5808_RS04455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5808_RS04470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5808_RS04490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5808_RS04525	COG1201	RNA secondary structure unwinding
B5808_RS04540	COG0513	Belongs to the DEAD box helicase family
B5808_RS04590	COG3739	integral membrane protein
B5808_RS04595	COG0085	RNA polymerase activity
B5808_RS04600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5808_RS04615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B5808_RS04620	COG0049	tRNA binding
B5808_RS04625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5808_RS04630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5808_RS04680	COG0051	transcription antitermination factor activity, RNA binding
B5808_RS04685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B5808_RS04690	COG0088	Forms part of the polypeptide exit tunnel
B5808_RS04695	COG0089	rRNA binding
B5808_RS04700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5808_RS04705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5808_RS04710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B5808_RS04715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B5808_RS04720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B5808_RS04725	COG0255	Belongs to the universal ribosomal protein uL29 family
B5808_RS04730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5808_RS04735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5808_RS04740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5808_RS04745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5808_RS04750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5808_RS04755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5808_RS04760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B5808_RS04765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B5808_RS04770	COG1841	ribosomal large subunit assembly
B5808_RS04775	COG0200	Binds to the 23S rRNA
B5808_RS04785	COG0563	adenylate kinase activity
B5808_RS04790	COG0024	Methionine aminopeptidase
B5808_RS04810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5808_RS04820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5808_RS04825	COG0246	Mannitol dehydrogenase
B5808_RS04840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B5808_RS04845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5808_RS04850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5808_RS04855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5808_RS04860	COG0202	RNA polymerase activity
B5808_RS04865	COG0203	ribosomal protein L17
B5808_RS04870	COG0101	tRNA pseudouridine synthase activity
B5808_RS04875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5808_RS04880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B5808_RS04885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5808_RS04890	COG1072	(Pantothenic acid kinase))
B5808_RS04895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B5808_RS04900	COG0736	holo-[acyl-carrier-protein] synthase activity
B5808_RS04905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5808_RS04910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5808_RS04915	COG0802	atpase or kinase
B5808_RS04925	COG0456	acetyltransferase
B5808_RS04925	COG1214	PFAM Peptidase M22, glycoprotease
B5808_RS04930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5808_RS04945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B5808_RS04990	COG0516	GMP reductase activity
B5808_RS04995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B5808_RS05005	COG0475	glutathione-regulated potassium exporter activity
B5808_RS05020	COG0519	Catalyzes the synthesis of GMP from XMP
B5808_RS05020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5808_RS05040	COG0584	glycerophosphoryl diester phosphodiesterase
B5808_RS05055	COG0045	succinate-CoA ligase (ADP-forming) activity
B5808_RS05080	COG0138	bifunctional purine biosynthesis protein purh
B5808_RS05085	COG1834	amidinotransferase
B5808_RS05090	COG1132	(ABC) transporter
B5808_RS05095	COG1132	(ABC) transporter
B5808_RS05125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B5808_RS05135	COG1940	carbohydrate kinase activity
B5808_RS05145	COG1175	transmembrane transport
B5808_RS05150	COG0395	ABC-type sugar transport system, permease component
B5808_RS05200	COG2814	Major facilitator Superfamily
B5808_RS05205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5808_RS05210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5808_RS05215	COG2017	converts alpha-aldose to the beta-anomer
B5808_RS05235	COG4115	mRNA cleavage
B5808_RS05240	COG2161	toxin-antitoxin pair type II binding
B5808_RS05260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5808_RS05285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B5808_RS05290	COG0456	acetyltransferase
B5808_RS05295	COG0745	RESPONSE REGULATOR receiver
B5808_RS05305	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B5808_RS05320	COG0588	phosphoglycerate mutase activity
B5808_RS05330	COG5002	protein histidine kinase activity
B5808_RS05335	COG0745	RESPONSE REGULATOR receiver
B5808_RS05345	COG1329	Transcriptional regulator
B5808_RS05350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B5808_RS05350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5808_RS05355	COG0215	cysteine-tRNA ligase activity
B5808_RS05360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5808_RS05370	COG3842	ATPase activity
B5808_RS05385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5808_RS05390	COG2814	Major facilitator Superfamily
B5808_RS05415	COG1278	Cold shock
B5808_RS05420	COG0459	protein refolding
B5808_RS05425	COG2205	protein histidine kinase activity
B5808_RS05430	COG0745	RESPONSE REGULATOR receiver
B5808_RS05435	COG1061	Type III restriction enzyme res subunit
B5808_RS05460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B5808_RS05465	COG1321	iron dependent repressor
B5808_RS05500	COG0457	Tetratricopeptide repeat
B5808_RS05530	COG2378	regulation of single-species biofilm formation
B5808_RS05540	COG1609	Transcriptional regulator
B5808_RS05555	COG0395	ABC-type sugar transport system, permease component
B5808_RS05575	COG0534	Mate efflux family protein
B5808_RS05585	COG0025	NhaP-type Na H and K H
B5808_RS05590	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B5808_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS05630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS05645	COG1970	mechanosensitive ion channel activity
B5808_RS05655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B5808_RS05660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B5808_RS05670	COG0745	RESPONSE REGULATOR receiver
B5808_RS05675	COG2205	protein histidine kinase activity
B5808_RS05705	COG0640	Transcriptional regulator
B5808_RS05710	COG0346	lactoylglutathione lyase activity
B5808_RS05720	COG2197	response regulator
B5808_RS05725	COG2755	lipolytic protein G-D-S-L family
B5808_RS05730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5808_RS05770	COG2161	toxin-antitoxin pair type II binding
B5808_RS05775	COG2026	Addiction module toxin, RelE StbE family
B5808_RS05790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5808_RS05810	COG2272	Belongs to the type-B carboxylesterase lipase family
B5808_RS05835	COG0318	PFAM AMP-dependent synthetase and ligase
B5808_RS05870	COG0656	L-ascorbic acid biosynthetic process
B5808_RS05880	COG1643	Atp-dependent helicase
B5808_RS05890	COG1331	Highly conserved protein containing a thioredoxin domain
B5808_RS05925	COG2855	membrane
B5808_RS05940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5808_RS05945	COG0084	hydrolase, TatD family'
B5808_RS05950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B5808_RS05960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B5808_RS05965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5808_RS05970	COG0488	(ABC) transporter
B5808_RS05975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5808_RS05980	COG1846	Transcriptional regulator
B5808_RS05990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5808_RS05995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B5808_RS06010	COG1063	alcohol dehydrogenase
B5808_RS06015	COG2814	Major facilitator Superfamily
B5808_RS06025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5808_RS06040	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B5808_RS06045	COG0228	four-way junction DNA binding
B5808_RS06050	COG1837	Belongs to the UPF0109 family
B5808_RS06055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B5808_RS06060	COG0336	Belongs to the RNA methyltransferase TrmD family
B5808_RS06075	COG0335	large ribosomal subunit rRNA binding
B5808_RS06080	COG0681	Belongs to the peptidase S26 family
B5808_RS06085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B5808_RS06095	COG0792	nuclease activity
B5808_RS06115	COG4974	Belongs to the 'phage' integrase family
B5808_RS06125	COG0477	Major facilitator Superfamily
B5808_RS06130	COG0052	Belongs to the universal ribosomal protein uS2 family
B5808_RS06135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B5808_RS06140	COG0528	UMP kinase activity
B5808_RS06145	COG0233	cytoplasmic translational termination
B5808_RS06165	COG0601	transmembrane transport
B5808_RS06220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B5808_RS06225	COG0366	Alpha amylase catalytic
B5808_RS06230	COG0058	SHG alpha-glucan phosphorylase activity
B5808_RS06245	COG1523	belongs to the glycosyl hydrolase 13 family
B5808_RS06260	COG0482	sulfurtransferase activity
B5808_RS06265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5808_RS06270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5808_RS06275	COG0154	amidase activity
B5808_RS06280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5808_RS06300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B5808_RS06305	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5808_RS06310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5808_RS06340	COG4721	ABC-type cobalt transport system, permease component
B5808_RS06345	COG1122	ATPase activity
B5808_RS06370	COG1357	PFAM Pentapeptide repeats (8 copies)
B5808_RS06390	COG0629	single-stranded DNA binding
B5808_RS06395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5808_RS06420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B5808_RS06450	COG0668	transmembrane transport
B5808_RS06460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B5808_RS06475	COG0318	PFAM AMP-dependent synthetase and ligase
B5808_RS06500	COG0783	Belongs to the Dps family
B5808_RS06510	COG0778	Nitroreductase
B5808_RS06540	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5808_RS06545	COG0740	serine-type endopeptidase activity
B5808_RS06550	COG0740	serine-type endopeptidase activity
B5808_RS06555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B5808_RS06560	COG3135	benzoate transporter
B5808_RS06590	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B5808_RS06610	COG0517	IMP dehydrogenase activity
B5808_RS06610	COG1125	glycine betaine transport
B5808_RS06615	COG1174	glycine betaine transport
B5808_RS06620	COG1174	glycine betaine transport
B5808_RS06635	COG1271	oxidase subunit
B5808_RS06640	COG1294	oxidase, subunit
B5808_RS06645	COG4988	ABC transporter
B5808_RS06650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B5808_RS06655	COG0495	leucyl-tRNA aminoacylation
B5808_RS06660	COG4948	Mandelate Racemase Muconate Lactonizing
B5808_RS06675	COG1555	photosystem II stabilization
B5808_RS06695	COG0268	Binds directly to 16S ribosomal RNA
B5808_RS06700	COG0436	Aminotransferase
B5808_RS06715	COG0481	GTPase activity
B5808_RS06735	COG1420	regulation of RNA biosynthetic process
B5808_RS06740	COG0484	heat shock protein binding
B5808_RS06750	COG0537	adenosine 5'-monophosphoramidase activity
B5808_RS06760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B5808_RS06770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B5808_RS06775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5808_RS06780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B5808_RS06785	COG1674	ftsk spoiiie
B5808_RS06795	COG1546	Belongs to the CinA family
B5808_RS06795	COG1058	Belongs to the CinA family
B5808_RS06800	COG1396	sequence-specific DNA binding
B5808_RS06810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5808_RS06815	COG2137	regulation of response to DNA damage stimulus
B5808_RS06820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5808_RS06825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5808_RS06830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B5808_RS06835	COG2813	Specifically methylates the guanine in position
B5808_RS06840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5808_RS06845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5808_RS06855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5808_RS06860	COG0131	Imidazoleglycerol-phosphate dehydratase
B5808_RS06865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5808_RS06870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5808_RS06885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B5808_RS06890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B5808_RS06895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B5808_RS06900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5808_RS06905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5808_RS06910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5808_RS06910	COG0072	phenylalanine-tRNA ligase activity
B5808_RS06915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B5808_RS06920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B5808_RS06925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5808_RS06930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5808_RS06935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B5808_RS06940	COG0165	Argininosuccinate lyase
B5808_RS06945	COG2094	Belongs to the DNA glycosylase MPG family
B5808_RS06950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5808_RS06975	COG1011	Hydrolase
B5808_RS06985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5808_RS06990	COG0497	DNA recombination
B5808_RS06995	COG0504	CTP synthase activity
B5808_RS07010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B5808_RS07020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B5808_RS07025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5808_RS07040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5808_RS07045	COG1160	GTP binding
B5808_RS07070	COG2084	Dehydrogenase
B5808_RS07075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5808_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS07100	COG0789	Transcriptional regulator
B5808_RS07105	COG0442	prolyl-tRNA aminoacylation
B5808_RS07115	COG0583	DNA-binding transcription factor activity
B5808_RS07120	COG0701	Predicted permease
B5808_RS07135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5808_RS07160	COG0488	(ABC) transporter
B5808_RS07170	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B5808_RS07180	COG1793	dna ligase
B5808_RS07185	COG2873	o-acetylhomoserine
B5808_RS07190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS07205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B5808_RS07240	COG0477	Major facilitator Superfamily
B5808_RS07265	COG0535	radical SAM domain protein
B5808_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS07295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5808_RS07340	COG0644	oxidoreductase
B5808_RS07350	COG1119	ATPase activity
B5808_RS07410	COG2169	Transcriptional regulator
B5808_RS07410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5808_RS07415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS07425	COG0484	heat shock protein binding
B5808_RS07450	COG0519	Catalyzes the synthesis of GMP from XMP
B5808_RS07455	COG0789	Transcriptional regulator
B5808_RS07475	COG0300	oxidoreductase activity
B5808_RS07480	COG0204	Acyl-transferase
B5808_RS07480	COG0318	PFAM AMP-dependent synthetase and ligase
B5808_RS07485	COG0277	FAD linked oxidase domain protein
B5808_RS07530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B5808_RS07565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5808_RS07590	COG0714	Associated with various cellular activities
B5808_RS07620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5808_RS07640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5808_RS07645	COG0750	zinc metalloprotease
B5808_RS07650	COG4585	Histidine kinase
B5808_RS07665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5808_RS07695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B5808_RS07700	COG0285	dihydrofolate synthase activity
B5808_RS07710	COG0105	UTP biosynthetic process
B5808_RS07725	COG1530	ribonuclease E activity
B5808_RS07735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5808_RS07740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B5808_RS07745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5808_RS07750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5808_RS07755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B5808_RS07765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B5808_RS07775	COG0799	negative regulation of ribosome biogenesis
B5808_RS07810	COG2197	response regulator
B5808_RS07830	COG1716	ATPase activity
B5808_RS07845	COG1192	Involved in chromosome partitioning
B5808_RS07865	COG1940	carbohydrate kinase activity
B5808_RS07870	COG0204	Acyl-transferase
B5808_RS07875	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B5808_RS07880	COG0515	serine threonine protein kinase
B5808_RS07880	COG2815	serine threonine protein kinase
B5808_RS07890	COG0142	geranyltranstransferase activity
B5808_RS07900	COG2001	Belongs to the MraZ family
B5808_RS07905	COG0275	rRNA processing
B5808_RS07915	COG0768	penicillin binding
B5808_RS07920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5808_RS07930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5808_RS07935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B5808_RS07945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5808_RS07950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5808_RS07960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5808_RS07965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B5808_RS07970	COG1799	cell septum assembly
B5808_RS07985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5808_RS07995	COG0587	DNA-directed DNA polymerase activity
B5808_RS08000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5808_RS08005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B5808_RS08010	COG0167	dihydroorotate dehydrogenase activity
B5808_RS08020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5808_RS08030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5808_RS08035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B5808_RS08045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B5808_RS08050	COG0723	plastoquinol--plastocyanin reductase activity
B5808_RS08055	COG2010	Cytochrome c
B5808_RS08060	COG1845	cytochrome c oxidase, subunit III
B5808_RS08065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5808_RS08070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B5808_RS08075	COG2376	Dihydroxyacetone kinase
B5808_RS08080	COG1461	Dihydroxyacetone kinase
B5808_RS08100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B5808_RS08105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5808_RS08110	COG0747	negative chemotaxis
B5808_RS08115	COG0601	transmembrane transport
B5808_RS08120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5808_RS08130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS08135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS08145	COG2873	o-acetylhomoserine
B5808_RS08160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS08175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5808_RS08180	COG1464	Belongs to the NlpA lipoprotein family
B5808_RS08190	COG3845	ABC transporter
B5808_RS08195	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5808_RS08200	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5808_RS08245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B5808_RS08280	COG0701	Predicted permease
B5808_RS08290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5808_RS08310	COG1595	DNA-templated transcription, initiation
B5808_RS08430	COG4221	oxidoreductase activity
B5808_RS08440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B5808_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS08475	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B5808_RS08485	COG2354	Protein conserved in bacteria
B5808_RS08490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5808_RS08545	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS08550	COG2814	Major facilitator Superfamily
B5808_RS08570	COG2140	Oxalate decarboxylase
B5808_RS08575	COG0477	Major facilitator Superfamily
B5808_RS08600	COG1129	ABC transporter
B5808_RS08630	COG2267	carboxylic ester hydrolase activity
B5808_RS08645	COG2197	response regulator
B5808_RS08660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5808_RS08675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5808_RS08680	COG0805	protein transport
B5808_RS08685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5808_RS08700	COG2197	response regulator
B5808_RS08710	COG3537	Alpha-1,2-mannosidase
B5808_RS08730	COG1846	Transcriptional regulator
B5808_RS08740	COG1294	oxidase, subunit
B5808_RS08745	COG1271	oxidase subunit
B5808_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS08820	COG4581	dead DEAH box helicase
B5808_RS08825	COG0805	protein transport
B5808_RS08830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5808_RS08855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5808_RS08865	COG0215	cysteine-tRNA ligase activity
B5808_RS08870	COG1968	undecaprenyl-diphosphatase activity
B5808_RS08875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5808_RS08890	COG3104	oligopeptide transport
B5808_RS08925	COG0406	alpha-ribazole phosphatase activity
B5808_RS08940	COG0366	Alpha amylase catalytic
B5808_RS08955	COG0254	rRNA binding
B5808_RS08960	COG1119	ATPase activity
B5808_RS08965	COG0297	glycogen (starch) synthase activity
B5808_RS08970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B5808_RS08975	COG0560	Phosphoserine phosphatase
B5808_RS08990	COG0488	(ABC) transporter
B5808_RS09010	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS09015	COG2151	metal-sulfur cluster biosynthetic enzyme
B5808_RS09020	COG0396	ATPase activity
B5808_RS09025	COG2146	nitrite reductase [NAD(P)H] activity
B5808_RS09030	COG0719	Fe-S assembly protein
B5808_RS09045	COG0109	protoheme IX farnesyltransferase activity
B5808_RS09055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B5808_RS09060	COG0166	Belongs to the GPI family
B5808_RS09075	COG0363	glucosamine-6-phosphate deaminase activity
B5808_RS09085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5808_RS09090	COG0149	triose-phosphate isomerase activity
B5808_RS09095	COG0126	phosphoglycerate kinase activity
B5808_RS09105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B5808_RS09110	COG1481	regulation of sporulation
B5808_RS09115	COG1660	Displays ATPase and GTPase activities
B5808_RS09120	COG0322	excinuclease ABC activity
B5808_RS09130	COG0556	nucleotide-excision repair
B5808_RS09140	COG1984	allophanate hydrolase subunit 2
B5808_RS09145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B5808_RS09150	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5808_RS09155	COG0237	dephospho-CoA kinase activity
B5808_RS09160	COG0539	negative regulation of cytoplasmic translation
B5808_RS09175	COG1090	epimerase
B5808_RS09200	COG0587	DNA-directed DNA polymerase activity
B5808_RS09210	COG2050	protein possibly involved in aromatic compounds catabolism
B5808_RS09240	COG0067	glutamate synthase
B5808_RS09240	COG0070	glutamate synthase
B5808_RS09240	COG0069	glutamate synthase activity
B5808_RS09245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B5808_RS09250	COG0159	tryptophan synthase activity
B5808_RS09255	COG0133	tryptophan synthase activity
B5808_RS09260	COG0134	indole-3-glycerol-phosphate synthase activity
B5808_RS09280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5808_RS09285	COG0107	imidazoleglycerol-phosphate synthase activity
B5808_RS09290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5808_RS09295	COG0140	phosphoribosyl-ATP diphosphatase activity
B5808_RS09300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5808_RS09315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5808_RS09325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5808_RS09335	COG1758	RNA polymerase activity
B5808_RS09340	COG0194	GDP metabolic process
B5808_RS09345	COG0284	orotidine-5'-phosphate decarboxylase activity
B5808_RS09350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5808_RS09355	COG0505	Belongs to the CarA family
B5808_RS09365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5808_RS09370	COG0540	Belongs to the ATCase OTCase family
B5808_RS09375	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B5808_RS09385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5808_RS09390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5808_RS09400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B5808_RS09410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5808_RS09415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5808_RS09425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B5808_RS09430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5808_RS09445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5808_RS09460	COG1196	nuclear chromosome segregation
B5808_RS09470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5808_RS09475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5808_RS09480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5808_RS09490	COG2255	four-way junction helicase activity
B5808_RS09495	COG0632	four-way junction helicase activity
B5808_RS09500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B5808_RS09505	COG0217	transcriptional regulatory protein
B5808_RS09510	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B5808_RS09515	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B5808_RS09525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5808_RS09540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5808_RS09625	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B5808_RS09630	COG0183	Belongs to the thiolase family
B5808_RS09650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5808_RS09655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B5808_RS09675	COG0756	dUTP diphosphatase activity
B5808_RS09700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5808_RS09710	COG0187	DNA topoisomerase II activity
B5808_RS09725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5808_RS09730	COG2814	Major facilitator Superfamily
B5808_RS09740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5808_RS09745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5808_RS09750	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5808_RS09770	COG0174	glutamine synthetase
B5808_RS09775	COG4974	Belongs to the 'phage' integrase family
B5808_RS09865	COG0656	L-ascorbic acid biosynthetic process
B5808_RS09875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B5808_RS09880	COG0174	glutamine synthetase
B5808_RS09890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B5808_RS09920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B5808_RS09955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B5808_RS09970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5808_RS09975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5808_RS09980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5808_RS09995	COG1305	Transglutaminase-like
B5808_RS10005	COG0714	Associated with various cellular activities
B5808_RS10025	COG0438	transferase activity, transferring glycosyl groups
B5808_RS10035	COG0242	peptide deformylase activity
B5808_RS10060	COG4608	Belongs to the ABC transporter superfamily
B5808_RS10065	COG0358	DNA primase activity
B5808_RS10080	COG0442	prolyl-tRNA aminoacylation
B5808_RS10090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5808_RS10095	COG1381	Involved in DNA repair and RecF pathway recombination
B5808_RS10105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5808_RS10120	COG1764	response to oxidative stress
B5808_RS10125	COG1090	epimerase
B5808_RS10135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5808_RS10150	COG0612	Peptidase, M16
B5808_RS10155	COG1185	polyribonucleotide nucleotidyltransferase activity
B5808_RS10165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5808_RS10170	COG3424	synthase
B5808_RS10180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B5808_RS10190	COG0477	Major facilitator Superfamily
B5808_RS10200	COG0545	Peptidyl-prolyl cis-trans isomerase
B5808_RS10210	COG0277	FAD linked oxidase domain protein
B5808_RS10220	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS10240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5808_RS10265	COG0702	epimerase
B5808_RS10270	COG2807	transmembrane transport
B5808_RS10290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5808_RS10300	COG1194	a g-specific adenine glycosylase
B5808_RS10305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B5808_RS10310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5808_RS10325	COG0442	prolyl-tRNA aminoacylation
B5808_RS10330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5808_RS10335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5808_RS10345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B5808_RS10350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B5808_RS10355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5808_RS10360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B5808_RS10365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5808_RS10370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5808_RS10375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5808_RS10380	COG0356	it plays a direct role in the translocation of protons across the membrane
B5808_RS10390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5808_RS10400	COG2890	protein-(glutamine-N5) methyltransferase activity
B5808_RS10405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5808_RS10415	COG0083	homoserine kinase activity
B5808_RS10420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B5808_RS10425	COG0460	homoserine dehydrogenase
B5808_RS10440	COG0018	arginyl-trna synthetase
B5808_RS10445	COG1305	Transglutaminase-like
B5808_RS10455	COG0514	ATP-dependent DNA helicase (RecQ)
B5808_RS10470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B5808_RS10480	COG1842	Phage shock protein A
B5808_RS10505	COG0154	amidase activity
B5808_RS10525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B5808_RS10530	COG2814	Major facilitator Superfamily
B5808_RS10545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5808_RS10585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B5808_RS10585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5808_RS10595	COG1253	flavin adenine dinucleotide binding
B5808_RS10605	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5808_RS10605	COG0567	Dehydrogenase, E1 component
B5808_RS10620	COG1595	DNA-templated transcription, initiation
B5808_RS10625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5808_RS10635	COG0483	inositol monophosphate 1-phosphatase activity
B5808_RS10645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5808_RS10670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B5808_RS10675	COG2177	Part of the ABC transporter FtsEX involved in
B5808_RS10680	COG2884	Cell division ATP-binding protein ftsE
B5808_RS10685	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B5808_RS10700	COG0586	Pfam SNARE associated Golgi protein
B5808_RS10710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B5808_RS10715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B5808_RS10720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B5808_RS10725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B5808_RS10750	COG3620	sequence-specific DNA binding
B5808_RS10770	COG1362	aminopeptidase activity
B5808_RS10785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS10810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5808_RS10820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5808_RS10840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5808_RS10855	COG2234	aminopeptidase activity
B5808_RS10865	COG0697	spore germination
B5808_RS10885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5808_RS10900	COG1674	ftsk spoiiie
B5808_RS10930	COG1120	ATPase activity
B5808_RS10935	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5808_RS10940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5808_RS10960	COG1615	UPF0182 protein
B5808_RS10965	COG3480	Lon protease (S16) C-terminal proteolytic domain
B5808_RS11020	COG0513	Belongs to the DEAD box helicase family
B5808_RS11025	COG0613	PHP domain protein
B5808_RS11030	COG0006	proline dipeptidase activity
B5808_RS11040	COG2239	Acts as a magnesium transporter
B5808_RS11050	COG0489	protein tyrosine kinase activity
B5808_RS11050	COG2151	metal-sulfur cluster biosynthetic enzyme
B5808_RS11055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5808_RS11060	COG4122	O-methyltransferase activity
B5808_RS11075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5808_RS11080	COG2171	N-acyltransferase activity
B5808_RS11110	COG2822	iron ion transport
B5808_RS11115	COG2837	iron assimilation
B5808_RS11125	COG1217	gtp-binding protein TYPA
B5808_RS11130	COG4172	Belongs to the ABC transporter superfamily
B5808_RS11140	COG0601	transmembrane transport
B5808_RS11160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5808_RS11160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5808_RS11165	COG0509	glycine decarboxylation via glycine cleavage system
B5808_RS11170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5808_RS11205	COG0012	GTP binding
B5808_RS11220	COG1322	Protein conserved in bacteria
B5808_RS11235	COG0477	Major facilitator Superfamily
B5808_RS11240	COG2186	Transcriptional regulator
B5808_RS11250	COG0191	fructose-bisphosphate aldolase activity
B5808_RS11260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B5808_RS11265	COG1570	exodeoxyribonuclease VII activity
B5808_RS11270	COG1722	exodeoxyribonuclease VII activity
B5808_RS11280	COG0288	reversible hydration of carbon dioxide
B5808_RS11285	COG0114	fumarate hydratase activity
B5808_RS11300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B5808_RS11305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5808_RS11310	COG1272	protein, Hemolysin III
B5808_RS11330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5808_RS11345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5808_RS11355	COG3214	Protein conserved in bacteria
B5808_RS11360	COG0501	Belongs to the peptidase M48B family
B5808_RS11365	COG1704	LemA family
B5808_RS11370	COG2723	6-phospho-beta-galactosidase activity
B5808_RS11405	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5808_RS11410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B5808_RS11415	COG2188	Transcriptional regulator
B5808_RS11455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B5808_RS11465	COG0561	phosphatase activity
B5808_RS11470	COG1850	ribulose-bisphosphate carboxylase activity
B5808_RS11485	COG2197	response regulator
B5808_RS11490	COG4585	Histidine kinase
B5808_RS11500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5808_RS11505	COG0149	triose-phosphate isomerase activity
B5808_RS11510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B5808_RS11545	COG1404	Belongs to the peptidase S8 family
B5808_RS11560	COG0148	phosphopyruvate hydratase activity
B5808_RS11580	COG2814	Major facilitator Superfamily
B5808_RS11590	COG0124	histidyl-tRNA synthetase
B5808_RS11595	COG1131	(ABC) transporter
B5808_RS11605	COG3956	TIGRFAM MazG family protein
B5808_RS11610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5808_RS11620	COG2233	PERMEase
B5808_RS11625	COG0193	aminoacyl-tRNA hydrolase activity
B5808_RS11630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B5808_RS11635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B5808_RS11640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B5808_RS11645	COG1196	nuclear chromosome segregation
B5808_RS11670	COG0315	cyclic pyranopterin monophosphate synthase activity
B5808_RS11675	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5808_RS11680	COG0314	molybdopterin synthase activity
B5808_RS11690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5808_RS11710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B5808_RS11710	COG3608	succinylglutamate desuccinylase aspartoacylase
B5808_RS11730	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS11740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5808_RS11760	COG0259	pyridoxamine-phosphate oxidase activity
B5808_RS11770	COG2271	Major facilitator Superfamily
B5808_RS11775	COG3537	Alpha-1,2-mannosidase
B5808_RS11780	COG0384	phenazine biosynthesis protein PhzF
B5808_RS11790	COG3961	Belongs to the TPP enzyme family
B5808_RS11805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5808_RS11825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5808_RS11845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5808_RS11860	COG3619	membrane
B5808_RS11865	COG1396	sequence-specific DNA binding
B5808_RS11870	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
B5808_RS11875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5808_RS11880	COG0571	ribonuclease III activity
B5808_RS11885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B5808_RS11895	COG0583	DNA-binding transcription factor activity
B5808_RS11900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5808_RS11905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5808_RS11910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5808_RS11920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5808_RS11930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5808_RS11950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B5808_RS11955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B5808_RS11960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B5808_RS11965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B5808_RS11975	COG1920	GTP binding
B5808_RS11990	COG0706	membrane insertase activity
B5808_RS11995	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B5808_RS11995	COG0778	Nitroreductase
B5808_RS12005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5808_RS12015	COG0742	ribosomal rna small subunit methyltransferase
B5808_RS12030	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5808_RS12035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B5808_RS12045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5808_RS12050	COG0066	3-isopropylmalate dehydratase activity
B5808_RS12055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5808_RS12090	COG3387	PFAM Glycoside hydrolase 15-related
B5808_RS12100	COG1215	transferase activity, transferring glycosyl groups
B5808_RS12130	COG0318	PFAM AMP-dependent synthetase and ligase
B5808_RS12160	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5808_RS12160	COG1902	pentaerythritol trinitrate reductase activity
B5808_RS12165	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS12170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B5808_RS12215	COG1289	transmembrane transporter activity
B5808_RS12220	COG3387	PFAM Glycoside hydrolase 15-related
B5808_RS12275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5808_RS12300	COG4941	Belongs to the sigma-70 factor family
B5808_RS12305	COG0492	ferredoxin-NADP+ reductase activity
B5808_RS12310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5808_RS12325	COG1131	(ABC) transporter
B5808_RS12330	COG1253	flavin adenine dinucleotide binding
B5808_RS12355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5808_RS12360	COG0588	phosphoglycerate mutase activity
B5808_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS12385	COG2030	dehydratase
B5808_RS12385	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS12395	COG2814	Major facilitator Superfamily
B5808_RS12400	COG2814	Major facilitator Superfamily
B5808_RS12410	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5808_RS12415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5808_RS12420	COG0473	3-isopropylmalate dehydrogenase activity
B5808_RS12460	COG0395	ABC-type sugar transport system, permease component
B5808_RS12475	COG1609	Transcriptional regulator
B5808_RS12480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B5808_RS12485	COG0440	acetolactate synthase activity
B5808_RS12490	COG0028	Belongs to the TPP enzyme family
B5808_RS12495	COG0129	dihydroxy-acid dehydratase activity
B5808_RS12525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5808_RS12530	COG2197	response regulator
B5808_RS12565	COG0653	protein targeting
B5808_RS12570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5808_RS12580	COG5401	PFAM Sporulation and spore germination
B5808_RS12585	COG5000	phosphorelay sensor kinase activity
B5808_RS12585	COG5002	protein histidine kinase activity
B5808_RS12590	COG0745	RESPONSE REGULATOR receiver
B5808_RS12610	COG0714	Associated with various cellular activities
B5808_RS12615	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B5808_RS12630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B5808_RS12665	COG1482	cell wall glycoprotein biosynthetic process
B5808_RS12670	COG1960	acyl-CoA dehydrogenase activity
B5808_RS12720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B5808_RS12750	COG3754	Rhamnan synthesis protein F
B5808_RS12800	COG1216	Glycosyl transferase, family 2
B5808_RS12800	COG0438	transferase activity, transferring glycosyl groups
B5808_RS12815	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B5808_RS12820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5808_RS12825	COG0463	Glycosyl transferase, family 2
B5808_RS12835	COG1216	Glycosyl transferase, family 2
B5808_RS12835	COG0463	Glycosyl transferase, family 2
B5808_RS12865	COG1316	TRANSCRIPTIONal
B5808_RS12890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5808_RS12895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B5808_RS12925	COG0424	maF-like protein
B5808_RS12930	COG4770	biotin carboxylase activity
B5808_RS12945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5808_RS12950	COG0028	Belongs to the TPP enzyme family
B5808_RS12970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B5808_RS12985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B5808_RS12990	COG1957	nucleoside hydrolase
B5808_RS13010	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5808_RS13015	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5808_RS13025	COG3845	ABC transporter
B5808_RS13030	COG1744	ABC transporter substrate-binding protein PnrA-like
B5808_RS13035	COG1744	ABC transporter substrate-binding protein PnrA-like
B5808_RS13045	COG0438	transferase activity, transferring glycosyl groups
B5808_RS13050	COG2009	succinate dehydrogenase
B5808_RS13080	COG1131	(ABC) transporter
B5808_RS13090	COG1132	(ABC) transporter
B5808_RS13095	COG0477	Major facilitator Superfamily
B5808_RS13100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5808_RS13105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5808_RS13110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5808_RS13110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5808_RS13125	COG1216	Glycosyl transferase, family 2
B5808_RS13135	COG4129	membrane
B5808_RS13145	COG0708	Exodeoxyribonuclease III
B5808_RS13150	COG0180	Tryptophanyl-tRNA synthetase
B5808_RS13155	COG1335	isochorismatase
B5808_RS13185	COG0470	DNA polymerase III
B5808_RS13190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5808_RS13195	COG1754	DNA topoisomerase type I activity
B5808_RS13195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5808_RS13230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5808_RS13260	COG1435	thymidine kinase activity
B5808_RS13270	COG0346	lactoylglutathione lyase activity
B5808_RS13295	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B5808_RS13305	COG2072	flavoprotein involved in K transport
B5808_RS13315	COG1278	Cold shock
B5808_RS13325	COG2197	response regulator
B5808_RS13330	COG4585	Histidine kinase
B5808_RS13390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5808_RS13405	COG0579	oxidoreductase
B5808_RS13420	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B5808_RS13425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5808_RS13430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B5808_RS13445	COG1045	serine acetyltransferase
B5808_RS13460	COG0438	transferase activity, transferring glycosyl groups
B5808_RS13480	COG0489	protein tyrosine kinase activity
B5808_RS13495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5808_RS13515	COG1309	transcriptional regulator
B5808_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS13530	COG1846	Transcriptional regulator
B5808_RS13575	COG2814	Major facilitator Superfamily
B5808_RS13580	COG2890	protein-(glutamine-N5) methyltransferase activity
B5808_RS13590	COG0789	Transcriptional regulator
B5808_RS13600	COG0586	Pfam SNARE associated Golgi protein
B5808_RS13630	COG5002	protein histidine kinase activity
B5808_RS13655	COG0745	RESPONSE REGULATOR receiver
B5808_RS13665	COG5001	Diguanylate cyclase
B5808_RS13690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B5808_RS13700	COG0456	acetyltransferase
B5808_RS13705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B5808_RS13730	COG0702	epimerase
B5808_RS13755	COG0477	Major facilitator Superfamily
B5808_RS13775	COG0154	amidase activity
B5808_RS13785	COG1914	H( )-stimulated, divalent metal cation uptake system
B5808_RS13805	COG4948	Mandelate Racemase Muconate Lactonizing
B5808_RS13845	COG4214	carbohydrate transport
B5808_RS13865	COG0318	PFAM AMP-dependent synthetase and ligase
B5808_RS13875	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS13880	COG0596	Alpha beta hydrolase
B5808_RS13880	COG2945	thiolester hydrolase activity
B5808_RS13885	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5808_RS13885	COG0596	Alpha beta hydrolase
B5808_RS13890	COG1929	Belongs to the glycerate kinase type-1 family
B5808_RS13895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5808_RS13935	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5808_RS13940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5808_RS13945	COG1780	Probably involved in ribonucleotide reductase function
B5808_RS13970	COG1132	(ABC) transporter
B5808_RS13980	COG0395	ABC-type sugar transport system, permease component
B5808_RS13985	COG1175	transmembrane transport
B5808_RS13990	COG1653	transport
B5808_RS13995	COG1609	Transcriptional regulator
B5808_RS14000	COG0222	ribosome binding
B5808_RS14005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5808_RS14010	COG2205	protein histidine kinase activity
B5808_RS14015	COG0745	RESPONSE REGULATOR receiver
B5808_RS14030	COG3321	synthase
B5808_RS14030	COG0604	alcohol dehydrogenase
B5808_RS14050	COG0081	regulation of translation
B5808_RS14055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B5808_RS14075	COG0628	permease
B5808_RS14080	COG2095	MarC family integral membrane protein
B5808_RS14085	COG0436	Aminotransferase
B5808_RS14105	COG1131	(ABC) transporter
B5808_RS14125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B5808_RS14135	COG2030	dehydratase
B5808_RS14140	COG0248	Ppx GppA phosphatase
B5808_RS14165	COG0366	Alpha amylase catalytic
B5808_RS14170	COG0739	heme binding
B5808_RS14205	COG1666	GTP binding
B5808_RS14210	COG0494	nUDIX hydrolase
B5808_RS14225	COG0142	geranyltranstransferase activity
B5808_RS14230	COG2226	methyltransferase
B5808_RS14235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5808_RS14245	COG0154	amidase activity
B5808_RS14255	COG1902	pentaerythritol trinitrate reductase activity
B5808_RS14270	COG4948	Mandelate Racemase Muconate Lactonizing
B5808_RS14285	COG0395	ABC-type sugar transport system, permease component
B5808_RS14290	COG1175	transmembrane transport
B5808_RS14315	COG1609	Transcriptional regulator
B5808_RS14335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5808_RS14365	COG1129	ABC transporter
B5808_RS14370	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS14380	COG0656	L-ascorbic acid biosynthetic process
B5808_RS14390	COG0513	Belongs to the DEAD box helicase family
B5808_RS14395	COG0628	permease
B5808_RS14400	COG0137	argininosuccinate synthase activity
B5808_RS14405	COG1690	Belongs to the RtcB family
B5808_RS14410	COG2070	2-Nitropropane dioxygenase
B5808_RS14420	COG2807	transmembrane transport
B5808_RS14425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5808_RS14440	COG2409	Drug exporters of the RND superfamily
B5808_RS14460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5808_RS14480	COG0515	serine threonine protein kinase
B5808_RS14490	COG0783	Belongs to the Dps family
B5808_RS14500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5808_RS14505	COG2364	Membrane
B5808_RS14515	COG2154	pterin-4-alpha-carbinolamine dehydratase
B5808_RS14565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B5808_RS14585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5808_RS14595	COG0667	Aldo Keto reductase
B5808_RS14600	COG0423	glycine-tRNA ligase activity
B5808_RS14605	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5808_RS14610	COG0039	L-malate dehydrogenase activity
B5808_RS14615	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B5808_RS14625	COG0531	amino acid
B5808_RS14650	COG0151	Belongs to the GarS family
B5808_RS14655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B5808_RS14660	COG0596	Alpha beta hydrolase
B5808_RS14685	COG0546	phosphoglycolate phosphatase activity
B5808_RS14690	COG3250	beta-galactosidase activity
B5808_RS14705	COG1609	Transcriptional regulator
B5808_RS14710	COG1653	transport
B5808_RS14715	COG1175	transmembrane transport
B5808_RS14720	COG0395	ABC-type sugar transport system, permease component
B5808_RS14735	COG3458	cephalosporin-C deacetylase activity
B5808_RS14740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5808_RS14760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5808_RS14770	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B5808_RS14775	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5808_RS14785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B5808_RS14810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5808_RS14860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B5808_RS14865	COG0859	PFAM glycosyl transferase family 9
B5808_RS14870	COG0438	transferase activity, transferring glycosyl groups
B5808_RS14880	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B5808_RS14885	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B5808_RS14885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B5808_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS14895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B5808_RS14900	COG0859	PFAM glycosyl transferase family 9
B5808_RS14905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B5808_RS14905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B5808_RS14920	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS14935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5808_RS14950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5808_RS14960	COG0754	glutathionylspermidine amidase activity
B5808_RS14970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5808_RS15030	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS15050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5808_RS15055	COG1120	ATPase activity
B5808_RS15070	COG0583	DNA-binding transcription factor activity
B5808_RS15095	COG2514	catechol 2,3-dioxygenase activity
B5808_RS15105	COG2313	pseudouridylate synthase activity
B5808_RS15120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5808_RS15125	COG0047	phosphoribosylformylglycinamidine synthase activity
B5808_RS15130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B5808_RS15135	COG0604	alcohol dehydrogenase
B5808_RS15145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B5808_RS15150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5808_RS15160	COG2259	Doxx family
B5808_RS15170	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS15180	COG0154	amidase activity
B5808_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS15230	COG0604	alcohol dehydrogenase
B5808_RS15230	COG3321	synthase
B5808_RS15255	COG2318	DinB family
B5808_RS15285	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS15290	COG1846	Transcriptional regulator
B5808_RS15295	COG1764	response to oxidative stress
B5808_RS15305	COG2409	Drug exporters of the RND superfamily
B5808_RS15310	COG2755	lipolytic protein G-D-S-L family
B5808_RS15310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B5808_RS15320	COG2382	esterase
B5808_RS15330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5808_RS15360	COG1175	transmembrane transport
B5808_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS15430	COG1802	Transcriptional regulator
B5808_RS15460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B5808_RS15475	COG1846	Transcriptional regulator
B5808_RS15480	COG0415	Belongs to the DNA photolyase family
B5808_RS15505	COG2860	membrane
B5808_RS15510	COG2272	Belongs to the type-B carboxylesterase lipase family
B5808_RS15520	COG0723	plastoquinol--plastocyanin reductase activity
B5808_RS15525	COG1045	serine acetyltransferase
B5808_RS15545	COG0477	Major facilitator Superfamily
B5808_RS15550	COG3012	SEC-C Motif Domain Protein
B5808_RS15585	COG0772	Belongs to the SEDS family
B5808_RS15660	COG0758	DNA mediated transformation
B5808_RS15680	COG3527	Alpha-acetolactate decarboxylase
B5808_RS15685	COG0686	Belongs to the AlaDH PNT family
B5808_RS15690	COG1522	sequence-specific DNA binding
B5808_RS15715	COG1609	Transcriptional regulator
B5808_RS15730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5808_RS15735	COG0813	purine-nucleoside phosphorylase activity
B5808_RS15740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B5808_RS15750	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS15760	COG1609	Transcriptional regulator
B5808_RS15765	COG1744	ABC transporter substrate-binding protein PnrA-like
B5808_RS15770	COG3845	ABC transporter
B5808_RS15775	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS15780	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5808_RS15785	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS15845	COG2226	methyltransferase
B5808_RS15855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5808_RS15865	COG1472	Belongs to the glycosyl hydrolase 3 family
B5808_RS15880	COG2267	carboxylic ester hydrolase activity
B5808_RS15940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B5808_RS15945	COG1309	transcriptional regulator
B5808_RS15950	COG1215	transferase activity, transferring glycosyl groups
B5808_RS15955	COG1472	Belongs to the glycosyl hydrolase 3 family
B5808_RS15990	COG2890	protein-(glutamine-N5) methyltransferase activity
B5808_RS15995	COG2860	membrane
B5808_RS16020	COG1309	transcriptional regulator
B5808_RS16025	COG2197	response regulator
B5808_RS16055	COG0542	response to heat
B5808_RS16080	COG3458	cephalosporin-C deacetylase activity
B5808_RS16100	COG0604	alcohol dehydrogenase
B5808_RS16110	COG1802	Transcriptional regulator
B5808_RS16145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5808_RS16160	COG1129	ABC transporter
B5808_RS16165	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS16195	COG0667	Aldo Keto reductase
B5808_RS16200	COG0667	Aldo Keto reductase
B5808_RS16210	COG0531	amino acid
B5808_RS16225	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS16230	COG3224	Antibiotic biosynthesis monooxygenase
B5808_RS16235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5808_RS16255	COG2375	cellular response to nickel ion
B5808_RS16260	COG0287	Prephenate dehydrogenase
B5808_RS16260	COG1605	Chorismate mutase
B5808_RS16290	COG2188	Transcriptional regulator
B5808_RS16295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B5808_RS16300	COG1869	D-ribose catabolic process
B5808_RS16305	COG1129	ABC transporter
B5808_RS16315	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS16330	COG1609	Transcriptional regulator
B5808_RS16335	COG3537	Alpha-1,2-mannosidase
B5808_RS16340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5808_RS16355	COG4221	oxidoreductase activity
B5808_RS16365	COG0512	Glutamine amidotransferase of anthranilate synthase
B5808_RS16365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5808_RS16375	COG4565	transcriptional regulatory protein
B5808_RS16380	COG3290	protein histidine kinase activity
B5808_RS16385	COG2851	Citrate transporter
B5808_RS16410	COG0384	phenazine biosynthesis protein PhzF
B5808_RS16440	COG0598	Magnesium transport protein CorA
B5808_RS16450	COG1104	cysteine desulfurase activity
B5808_RS16460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B5808_RS16465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B5808_RS16490	COG2814	Major facilitator Superfamily
B5808_RS16495	COG1316	TRANSCRIPTIONal
B5808_RS16500	COG2315	Protein conserved in bacteria
B5808_RS16520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5808_RS16550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5808_RS16560	COG0515	serine threonine protein kinase
B5808_RS16575	COG1136	(ABC) transporter
B5808_RS16585	COG1309	transcriptional regulator
B5808_RS16605	COG1846	Transcriptional regulator
B5808_RS16625	COG1216	Glycosyl transferase, family 2
B5808_RS16630	COG0028	Belongs to the TPP enzyme family
B5808_RS16645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B5808_RS16645	COG2755	lipolytic protein G-D-S-L family
B5808_RS16665	COG3585	molybdate ion transport
B5808_RS16685	COG0477	Major facilitator Superfamily
B5808_RS16695	COG2017	converts alpha-aldose to the beta-anomer
B5808_RS16710	COG1501	Belongs to the glycosyl hydrolase 31 family
B5808_RS16715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5808_RS16720	COG2011	ABC-type metal ion transport system permease component
B5808_RS16725	COG1464	Belongs to the NlpA lipoprotein family
B5808_RS16730	COG2409	Drug exporters of the RND superfamily
B5808_RS16745	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B5808_RS16760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5808_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS16775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5808_RS16785	COG0386	Belongs to the glutathione peroxidase family
B5808_RS16800	COG0259	pyridoxamine-phosphate oxidase activity
B5808_RS16815	COG1609	Transcriptional regulator
B5808_RS16820	COG2814	Major facilitator Superfamily
B5808_RS16825	COG0640	Transcriptional regulator
B5808_RS16850	COG4989	oxidoreductase activity
B5808_RS16870	COG2807	transmembrane transport
B5808_RS16875	COG2186	Transcriptional regulator
B5808_RS16880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5808_RS16915	COG1802	Transcriptional regulator
B5808_RS16925	COG0022	dehydrogenase e1 component
B5808_RS16930	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5808_RS16935	COG1063	alcohol dehydrogenase
B5808_RS16940	COG0402	S-adenosylhomocysteine deaminase activity
B5808_RS16945	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS16955	COG1129	ABC transporter
B5808_RS17050	COG1482	cell wall glycoprotein biosynthetic process
B5808_RS17055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5808_RS17060	COG1802	Transcriptional regulator
B5808_RS17070	COG0395	ABC-type sugar transport system, permease component
B5808_RS17075	COG1175	transmembrane transport
B5808_RS17080	COG1653	transport
B5808_RS17100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B5808_RS17115	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS17190	COG1396	sequence-specific DNA binding
B5808_RS17195	COG0477	Major facilitator Superfamily
B5808_RS17205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5808_RS17210	COG1024	Enoyl-CoA hydratase
B5808_RS17220	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS17225	COG1012	belongs to the aldehyde dehydrogenase family
B5808_RS17245	COG1070	Carbohydrate kinase
B5808_RS17250	COG3347	Dehydrogenase
B5808_RS17250	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS17270	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS17275	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS17280	COG1129	ABC transporter
B5808_RS17285	COG1609	Transcriptional regulator
B5808_RS17300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5808_RS17360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5808_RS17390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5808_RS17395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B5808_RS17410	COG0436	Aminotransferase
B5808_RS17440	COG0312	modulator of DNA gyrase
B5808_RS17445	COG0673	inositol 2-dehydrogenase activity
B5808_RS17450	COG0601	transmembrane transport
B5808_RS17455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5808_RS17460	COG4608	Belongs to the ABC transporter superfamily
B5808_RS17470	COG0747	negative chemotaxis
B5808_RS17485	COG2160	L-arabinose isomerase activity
B5808_RS17505	COG1609	Transcriptional regulator
B5808_RS17510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5808_RS17515	COG1609	Transcriptional regulator
B5808_RS17525	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS17530	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS17540	COG1879	ABC-type sugar transport system periplasmic component
B5808_RS17560	COG0235	Class ii aldolase
B5808_RS17565	COG3395	kinase activity
B5808_RS17585	COG0473	3-isopropylmalate dehydrogenase activity
B5808_RS17590	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B5808_RS17595	COG2851	Citrate transporter
B5808_RS17635	COG0693	protein deglycase activity
B5808_RS17650	COG0346	lactoylglutathione lyase activity
B5808_RS17660	COG0657	acetylesterase activity
B5808_RS17670	COG0772	Belongs to the SEDS family
B5808_RS17685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5808_RS17690	COG2197	response regulator
B5808_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS17700	COG1309	transcriptional regulator
B5808_RS17740	COG0300	oxidoreductase activity
B5808_RS17750	COG2197	response regulator
B5808_RS17775	COG2814	Major facilitator Superfamily
B5808_RS17800	COG1733	regulation of RNA biosynthetic process
B5808_RS17805	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS17870	COG1414	Transcriptional regulator
B5808_RS17875	COG0183	Belongs to the thiolase family
B5808_RS17880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B5808_RS17890	COG5002	protein histidine kinase activity
B5808_RS17905	COG0745	RESPONSE REGULATOR receiver
B5808_RS17910	COG2205	protein histidine kinase activity
B5808_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS17920	COG0583	DNA-binding transcription factor activity
B5808_RS17940	COG2207	Transcriptional regulator
B5808_RS18010	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS18015	COG1879	ABC-type sugar transport system periplasmic component
B5808_RS18035	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS18050	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5808_RS18055	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5808_RS18060	COG3845	ABC transporter
B5808_RS18065	COG1744	ABC transporter substrate-binding protein PnrA-like
B5808_RS18075	COG1802	Transcriptional regulator
B5808_RS18085	COG0252	asparaginase activity
B5808_RS18140	COG1309	transcriptional regulator
B5808_RS18155	COG0114	fumarate hydratase activity
B5808_RS18170	COG2217	Heavy metal translocating P-type atpase
B5808_RS18175	COG1937	Protein conserved in bacteria
B5808_RS18185	COG0542	response to heat
B5808_RS18195	COG2813	Specifically methylates the guanine in position
B5808_RS18225	COG0601	transmembrane transport
B5808_RS18230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5808_RS18240	COG2267	carboxylic ester hydrolase activity
B5808_RS18270	COG0789	Transcriptional regulator
B5808_RS18275	COG0484	heat shock protein binding
B5808_RS18280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5808_RS18285	COG0443	Heat shock 70 kDa protein
B5808_RS18290	COG1316	TRANSCRIPTIONal
B5808_RS18295	COG0135	phosphoribosylanthranilate isomerase activity
B5808_RS18320	COG2111	Na H antiporter
B5808_RS18320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B5808_RS18325	COG1006	Multisubunit Na H antiporter MnhC subunit
B5808_RS18330	COG0651	ATP synthesis coupled electron transport
B5808_RS18340	COG2212	antiporter activity
B5808_RS18345	COG1320	monovalent cation:proton antiporter activity
B5808_RS18355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5808_RS18380	COG4221	oxidoreductase activity
B5808_RS18385	COG2197	response regulator
B5808_RS18400	COG2186	Transcriptional regulator
B5808_RS18405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5808_RS18410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5808_RS18430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5808_RS18445	COG3842	ATPase activity
B5808_RS18490	COG2197	response regulator
B5808_RS18495	COG4585	Histidine kinase
B5808_RS18505	COG1131	(ABC) transporter
B5808_RS18550	COG0142	geranyltranstransferase activity
B5808_RS18555	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B5808_RS18560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5808_RS18565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5808_RS18575	COG0800	Aldolase
B5808_RS18590	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS18595	COG1129	ABC transporter
B5808_RS18605	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS18620	COG1414	Transcriptional regulator
B5808_RS18680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5808_RS18685	COG0717	Belongs to the dCTP deaminase family
B5808_RS18705	COG0657	acetylesterase activity
B5808_RS18745	COG0445	tRNA wobble uridine modification
B5808_RS18750	COG0477	Major facilitator Superfamily
B5808_RS18770	COG2409	Drug exporters of the RND superfamily
B5808_RS18785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5808_RS18805	COG0776	regulation of translation
B5808_RS18810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5808_RS18815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5808_RS18820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B5808_RS18825	COG0735	belongs to the Fur family
B5808_RS18835	COG1121	(ABC) transporter
B5808_RS18860	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5808_RS18865	COG0022	dehydrogenase e1 component
B5808_RS18875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5808_RS18880	COG1950	PFAM Membrane protein of
B5808_RS18885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5808_RS18890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5808_RS18915	COG0596	Alpha beta hydrolase
B5808_RS18930	COG0305	Participates in initiation and elongation during chromosome replication
B5808_RS18935	COG0359	binds to the 23S rRNA
B5808_RS18940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B5808_RS18950	COG0360	Binds together with S18 to 16S ribosomal RNA
B5808_RS18955	COG0438	transferase activity, transferring glycosyl groups
B5808_RS18960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B5808_RS18970	COG0617	tRNA 3'-terminal CCA addition
B5808_RS18985	COG0492	ferredoxin-NADP+ reductase activity
B5808_RS18990	COG3118	belongs to the thioredoxin family
B5808_RS18995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5808_RS19000	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5808_RS19010	COG1192	Involved in chromosome partitioning
B5808_RS19020	COG0357	Ribosomal RNA small subunit methyltransferase G
B5808_RS19030	COG0706	membrane insertase activity
B5808_RS19035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B5808_RS19045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B5808_RS19095	COG1309	transcriptional regulator
B5808_RS19100	COG1960	acyl-CoA dehydrogenase activity
B5808_RS19110	COG1024	Enoyl-CoA hydratase
B5808_RS19115	COG1024	Enoyl-CoA hydratase
B5808_RS19120	COG0318	PFAM AMP-dependent synthetase and ligase
B5808_RS19135	COG1946	Acyl-CoA thioesterase
B5808_RS19145	COG0183	Belongs to the thiolase family
B5808_RS19195	COG3842	ATPase activity
B5808_RS19210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5808_RS19310	COG0739	heme binding
B5808_RS19325	COG1937	Protein conserved in bacteria
B5808_RS19330	COG2217	Heavy metal translocating P-type atpase
B5808_RS19385	COG1793	dna ligase
B5808_RS19405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5808_RS19410	COG0785	Cytochrome C biogenesis protein
B5808_RS19425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5808_RS19450	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5808_RS19485	COG1937	Protein conserved in bacteria
B5808_RS19500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B5808_RS19510	COG0640	Transcriptional regulator
B5808_RS19540	COG0745	RESPONSE REGULATOR receiver
B5808_RS19570	COG1316	TRANSCRIPTIONal
B5808_RS19575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5808_RS19600	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B5808_RS19605	COG1968	undecaprenyl-diphosphatase activity
B5808_RS19610	COG2205	protein histidine kinase activity
B5808_RS19615	COG0745	RESPONSE REGULATOR receiver
B5808_RS19630	COG0586	Pfam SNARE associated Golgi protein
B5808_RS19660	COG5002	protein histidine kinase activity
B5808_RS19690	COG0640	Transcriptional regulator
B5808_RS19705	COG4942	peptidase
B5808_RS19720	COG0785	Cytochrome C biogenesis protein
B5808_RS19770	COG2372	response to copper ion
B5808_RS19785	COG1196	nuclear chromosome segregation
B5808_RS19785	COG0739	heme binding
B5808_RS19785	COG0741	lytic transglycosylase activity
B5808_RS20050	COG1793	dna ligase
B5808_RS20085	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS20090	COG3958	Transketolase
B5808_RS20095	COG3959	Transketolase, thiamine diphosphate binding domain
B5808_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
B5808_RS20130	COG1063	alcohol dehydrogenase
B5808_RS20145	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5808_RS20155	COG1129	ABC transporter
B5808_RS20175	COG1414	Transcriptional regulator
B5808_RS20180	COG0511	ligase activity, forming carbon-carbon bonds
B5808_RS20180	COG5016	pyruvate
B5808_RS20190	COG0439	Biotin carboxylase
B5808_RS20195	COG1268	BioY protein
B5808_RS20205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B5808_RS20210	COG0183	Belongs to the thiolase family
B5808_RS20220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B5808_RS20240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5808_RS20285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B5808_RS20290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B5808_RS20310	COG0387	Pfam Sodium calcium exchanger
B5808_RS20340	COG0785	Cytochrome C biogenesis protein
B5808_RS20375	COG2372	response to copper ion
B5808_RS20390	COG1196	nuclear chromosome segregation
B5808_RS20390	COG0739	heme binding
B5808_RS20390	COG0741	lytic transglycosylase activity
B5808_RS20395	COG1333	cytochrome c biogenesis protein