locus-tag	class	description
FX986_RS00005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FX986_RS00040	COG4948	Mandelate Racemase Muconate Lactonizing
FX986_RS00045	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS00050	COG3734	2-keto-3-deoxy-galactonokinase
FX986_RS00055	COG0800	Aldolase
FX986_RS00060	COG3386	PFAM SMP-30 Gluconolaconase
FX986_RS00075	COG2610	gluconate transmembrane transporter activity
FX986_RS00085	COG1289	transmembrane transporter activity
FX986_RS00090	COG1566	PFAM secretion protein HlyD family protein
FX986_RS00110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS00120	COG1191	sigma factor activity
FX986_RS00190	COG1987	bacterial-type flagellum assembly
FX986_RS00200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FX986_RS00205	COG1256	bacterial-type flagellum assembly
FX986_RS00210	COG3951	Flagellar rod assembly protein muramidase FlgJ
FX986_RS00210	COG1705	Flagellar rod assembly protein muramidase FlgJ
FX986_RS00215	COG1706	bacterial-type flagellum-dependent cell motility
FX986_RS00230	COG4787	bacterial-type flagellum-dependent cell motility
FX986_RS00235	COG1749	Flagellar hook protein flgE
FX986_RS00240	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FX986_RS00245	COG1558	bacterial-type flagellum-dependent cell motility
FX986_RS00250	COG1815	bacterial-type flagellum-dependent cell motility
FX986_RS00275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FX986_RS00285	COG1360	Flagellar Motor Protein
FX986_RS00320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FX986_RS00325	COG1869	D-ribose catabolic process
FX986_RS00330	COG1129	ABC transporter
FX986_RS00335	COG1172	Belongs to the binding-protein-dependent transport system permease family
FX986_RS00340	COG1879	ABC-type sugar transport system periplasmic component
FX986_RS00345	COG1609	Transcriptional regulator
FX986_RS00350	COG2814	Major facilitator Superfamily
FX986_RS00370	COG2010	Cytochrome c
FX986_RS00390	COG2207	Transcriptional regulator
FX986_RS00390	COG0662	Cupin 2, conserved barrel domain protein
FX986_RS00395	COG0697	spore germination
FX986_RS00410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FX986_RS00415	COG0243	molybdopterin cofactor binding
FX986_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS00450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FX986_RS00455	COG0531	amino acid
FX986_RS00460	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS00465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FX986_RS00470	COG0833	amino acid
FX986_RS00475	COG2040	homocysteine
FX986_RS00485	COG1957	nucleoside hydrolase
FX986_RS00515	COG0318	PFAM AMP-dependent synthetase and ligase
FX986_RS00545	COG2873	o-acetylhomoserine
FX986_RS00560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS00570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS00570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS00590	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS00595	COG0583	DNA-binding transcription factor activity
FX986_RS00605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS00615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS00665	COG3314	Sporulation integral membrane protein YlbJ
FX986_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS00685	COG1252	NADH dehydrogenase
FX986_RS00695	COG2814	Major facilitator Superfamily
FX986_RS00700	COG1609	Transcriptional regulator
FX986_RS00730	COG2942	2-epimerase
FX986_RS00740	COG1473	amidohydrolase
FX986_RS00750	COG0583	DNA-binding transcription factor activity
FX986_RS00810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FX986_RS00820	COG3023	N-Acetylmuramoyl-L-alanine amidase
FX986_RS00855	COG0556	nucleotide-excision repair
FX986_RS00875	COG5001	Diguanylate cyclase
FX986_RS00875	COG3300	MHYT domain
FX986_RS00880	COG0084	hydrolase, TatD family'
FX986_RS00885	COG1970	mechanosensitive ion channel activity
FX986_RS00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FX986_RS00910	COG0789	Transcriptional regulator
FX986_RS00940	COG0583	DNA-binding transcription factor activity
FX986_RS00945	COG0625	glutathione transferase activity
FX986_RS00955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FX986_RS00970	COG0415	Belongs to the DNA photolyase family
FX986_RS00975	COG5000	phosphorelay sensor kinase activity
FX986_RS00980	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FX986_RS00985	COG1024	Enoyl-CoA hydratase
FX986_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS01020	COG5001	Diguanylate cyclase
FX986_RS01020	COG5002	protein histidine kinase activity
FX986_RS01050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FX986_RS01055	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS01060	COG1230	cation diffusion facilitator family transporter
FX986_RS01075	COG4807	Protein conserved in bacteria
FX986_RS01085	COG1064	alcohol dehydrogenase
FX986_RS01100	COG2188	Transcriptional regulator
FX986_RS01105	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FX986_RS01125	COG3842	ATPase activity
FX986_RS01150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FX986_RS01155	COG0640	Transcriptional regulator
FX986_RS01160	COG3118	belongs to the thioredoxin family
FX986_RS01170	COG2814	Major facilitator Superfamily
FX986_RS01185	COG0656	L-ascorbic acid biosynthetic process
FX986_RS01190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FX986_RS01195	COG4988	ABC transporter
FX986_RS01200	COG1294	oxidase, subunit
FX986_RS01205	COG1271	oxidase subunit
FX986_RS01210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FX986_RS01215	COG4773	Receptor
FX986_RS01225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FX986_RS01230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FX986_RS01235	COG1120	ATPase activity
FX986_RS01260	COG1116	anion transmembrane transporter activity
FX986_RS01275	COG0439	Biotin carboxylase
FX986_RS01300	COG1944	ATP diphosphatase activity
FX986_RS01330	COG0583	DNA-binding transcription factor activity
FX986_RS01335	COG0667	Aldo Keto reductase
FX986_RS01340	COG2249	NAD(P)H dehydrogenase (quinone) activity
FX986_RS01395	COG4964	Belongs to the GSP D family
FX986_RS01415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FX986_RS01435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FX986_RS01460	COG0583	DNA-binding transcription factor activity
FX986_RS01465	COG2828	Protein conserved in bacteria
FX986_RS01485	COG1253	flavin adenine dinucleotide binding
FX986_RS01495	COG0583	DNA-binding transcription factor activity
FX986_RS01505	COG1902	pentaerythritol trinitrate reductase activity
FX986_RS01505	COG0446	pyridine nucleotide-disulphide oxidoreductase
FX986_RS01510	COG3036	rescue of stalled ribosome
FX986_RS01525	COG0004	ammonium transporteR
FX986_RS01530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FX986_RS01535	COG3850	Histidine kinase
FX986_RS01540	COG2197	response regulator
FX986_RS01555	COG2076	Multidrug Resistance protein
FX986_RS01560	COG2076	Multidrug Resistance protein
FX986_RS01570	COG0583	DNA-binding transcription factor activity
FX986_RS01585	COG0583	DNA-binding transcription factor activity
FX986_RS01600	COG1454	alcohol dehydrogenase
FX986_RS01605	COG0659	secondary active sulfate transmembrane transporter activity
FX986_RS01610	COG3829	transcription factor binding
FX986_RS01615	COG3706	GGDEF domain
FX986_RS01615	COG4251	negative regulation of phosphorylation
FX986_RS01615	COG5001	Diguanylate cyclase
FX986_RS01615	COG2203	Gaf domain
FX986_RS01635	COG2610	gluconate transmembrane transporter activity
FX986_RS01640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FX986_RS01645	COG3622	Belongs to the hyi family
FX986_RS01650	COG0235	Class ii aldolase
FX986_RS01655	COG3395	kinase activity
FX986_RS01660	COG2084	Dehydrogenase
FX986_RS01665	COG1609	Transcriptional regulator
FX986_RS01680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX986_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS01700	COG1917	Cupin 2, conserved barrel domain protein
FX986_RS01705	COG1414	Transcriptional regulator
FX986_RS01715	COG3246	L-lysine catabolic process to acetate
FX986_RS01770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS01780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS01785	COG0156	8-amino-7-oxononanoate synthase activity
FX986_RS01790	COG1063	alcohol dehydrogenase
FX986_RS01795	COG0583	DNA-binding transcription factor activity
FX986_RS01805	COG1741	Belongs to the pirin family
FX986_RS01820	COG0697	spore germination
FX986_RS01825	COG1620	l-lactate permease
FX986_RS01840	COG1335	isochorismatase
FX986_RS01845	COG0251	oxidation-reduction process
FX986_RS01850	COG3314	Sporulation integral membrane protein YlbJ
FX986_RS01860	COG5006	permease, DMT superfamily
FX986_RS01875	COG0625	glutathione transferase activity
FX986_RS01885	COG0583	DNA-binding transcription factor activity
FX986_RS01890	COG0583	DNA-binding transcription factor activity
FX986_RS01895	COG1045	serine acetyltransferase
FX986_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS01915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS01920	COG2936	dipeptidyl-peptidase activity
FX986_RS01925	COG0583	DNA-binding transcription factor activity
FX986_RS01935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX986_RS01950	COG2188	Transcriptional regulator
FX986_RS01955	COG2186	Transcriptional regulator
FX986_RS01985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FX986_RS01990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FX986_RS02010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS02020	COG1312	Catalyzes the dehydration of D-mannonate
FX986_RS02025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FX986_RS02060	COG2375	cellular response to nickel ion
FX986_RS02070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FX986_RS02075	COG2706	6-phosphogluconolactonase activity
FX986_RS02080	COG0235	Class ii aldolase
FX986_RS02085	COG3395	kinase activity
FX986_RS02095	COG0473	3-isopropylmalate dehydrogenase activity
FX986_RS02115	COG2186	Transcriptional regulator
FX986_RS02140	COG0753	catalase activity
FX986_RS02145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS02150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FX986_RS02160	COG1942	4-Oxalocrotonate Tautomerase
FX986_RS02185	COG0583	DNA-binding transcription factor activity
FX986_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS02200	COG2010	Cytochrome c
FX986_RS02235	COG0583	DNA-binding transcription factor activity
FX986_RS02250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FX986_RS02255	COG1088	dTDP-glucose 4,6-dehydratase activity
FX986_RS02265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FX986_RS02265	COG0517	IMP dehydrogenase activity
FX986_RS02275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FX986_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS02335	COG3321	synthase
FX986_RS02335	COG0604	alcohol dehydrogenase
FX986_RS02355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FX986_RS02360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX986_RS02370	COG0156	8-amino-7-oxononanoate synthase activity
FX986_RS02380	COG3307	-O-antigen
FX986_RS02395	COG1051	belongs to the nudix hydrolase family
FX986_RS02400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FX986_RS02420	COG0438	transferase activity, transferring glycosyl groups
FX986_RS02445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FX986_RS02475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX986_RS02480	COG0028	Belongs to the TPP enzyme family
FX986_RS02485	COG2070	2-Nitropropane dioxygenase
FX986_RS02525	COG2186	Transcriptional regulator
FX986_RS02535	COG4948	Mandelate Racemase Muconate Lactonizing
FX986_RS02545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS02550	COG3618	amidohydrolase
FX986_RS02555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS02560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS02565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS02570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS02580	COG3618	amidohydrolase
FX986_RS02595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FX986_RS02630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS02630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS02640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS02660	COG1121	(ABC) transporter
FX986_RS02665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FX986_RS02675	COG0697	spore germination
FX986_RS02690	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FX986_RS02695	COG0830	nickel cation binding
FX986_RS02700	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FX986_RS02705	COG0804	urea catabolic process
FX986_RS02710	COG0832	Belongs to the urease beta subunit family
FX986_RS02715	COG0831	urea catabolic process
FX986_RS02720	COG0829	nickel cation binding
FX986_RS02750	COG4974	Belongs to the 'phage' integrase family
FX986_RS02795	COG5642	Protein of unknown function (DUF2384)
FX986_RS02800	COG5654	RES domain protein
FX986_RS02830	COG5001	Diguanylate cyclase
FX986_RS02850	COG2175	clavaminate synthase activity
FX986_RS02865	COG3791	Glutathione-dependent formaldehyde-activating
FX986_RS02870	COG0583	DNA-binding transcription factor activity
FX986_RS02930	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FX986_RS02935	COG0352	thiamine-phosphate diphosphorylase activity
FX986_RS02940	COG0531	amino acid
FX986_RS02950	COG4303	Ethanolamine ammonia lyase large subunit
FX986_RS02960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FX986_RS02975	COG0438	transferase activity, transferring glycosyl groups
FX986_RS03005	COG2244	polysaccharide biosynthetic process
FX986_RS03020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FX986_RS03025	COG0489	protein tyrosine kinase activity
FX986_RS03025	COG3206	protein involved in exopolysaccharide biosynthesis
FX986_RS03030	COG1596	polysaccharide export
FX986_RS03040	COG0438	transferase activity, transferring glycosyl groups
FX986_RS03045	COG0438	transferase activity, transferring glycosyl groups
FX986_RS03065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FX986_RS03080	COG1215	transferase activity, transferring glycosyl groups
FX986_RS03105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FX986_RS03115	COG1596	polysaccharide export
FX986_RS03140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX986_RS03150	COG0427	acetyl-CoA hydrolase
FX986_RS03165	COG1611	Belongs to the LOG family
FX986_RS03190	COG0583	DNA-binding transcription factor activity
FX986_RS03195	COG0432	Pfam Uncharacterised protein family UPF0047
FX986_RS03210	COG0628	permease
FX986_RS03215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FX986_RS03220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FX986_RS03225	COG3240	lipase activity
FX986_RS03225	COG4625	pathogenesis
FX986_RS03230	COG0717	Belongs to the dCTP deaminase family
FX986_RS03235	COG0489	protein tyrosine kinase activity
FX986_RS03255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FX986_RS03255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FX986_RS03265	COG4657	Part of a membrane complex involved in electron transport
FX986_RS03270	COG2878	Part of a membrane complex involved in electron transport
FX986_RS03275	COG4656	Part of a membrane complex involved in electron transport
FX986_RS03280	COG4658	electron transport chain
FX986_RS03285	COG4659	FMN binding
FX986_RS03290	COG4660	Part of a membrane complex involved in electron transport
FX986_RS03295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FX986_RS03310	COG2252	PERMEase
FX986_RS03320	COG0688	phosphatidylethanolamine metabolic process
FX986_RS03330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FX986_RS03350	COG3830	Belongs to the UPF0237 family
FX986_RS03350	COG0560	Phosphoserine phosphatase
FX986_RS03370	COG0166	Belongs to the GPI family
FX986_RS03375	COG4106	trans-aconitate 2-methyltransferase activity
FX986_RS03380	COG0500	methyltransferase
FX986_RS03385	COG3604	Transcriptional regulator
FX986_RS03395	COG2895	sulfate adenylyltransferase (ATP) activity
FX986_RS03400	COG0175	sulfate reduction
FX986_RS03405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FX986_RS03410	COG3151	Protein conserved in bacteria
FX986_RS03415	COG0494	nUDIX hydrolase
FX986_RS03425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FX986_RS03430	COG2813	Specifically methylates the guanine in position
FX986_RS03440	COG0438	transferase activity, transferring glycosyl groups
FX986_RS03550	COG1802	Transcriptional regulator
FX986_RS03550	COG4626	Terminase
FX986_RS03625	COG4626	Terminase
FX986_RS03625	COG1802	Transcriptional regulator
FX986_RS03700	COG0582	viral genome integration into host DNA
FX986_RS03715	COG0159	tryptophan synthase activity
FX986_RS03730	COG0788	formyltetrahydrofolate deformylase activity
FX986_RS03745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FX986_RS03750	COG0314	molybdopterin synthase activity
FX986_RS03755	COG0315	cyclic pyranopterin monophosphate synthase activity
FX986_RS03760	COG0303	'Molybdopterin
FX986_RS03765	COG1763	Mo-molybdopterin cofactor biosynthetic process
FX986_RS03770	COG0746	molybdenum cofactor guanylyltransferase activity
FX986_RS03780	COG4662	Binding-protein-dependent transport system inner membrane component
FX986_RS03790	COG2204	response regulator
FX986_RS03795	COG3852	Histidine kinase
FX986_RS03800	COG1917	Cupin 2, conserved barrel domain protein
FX986_RS03800	COG1396	sequence-specific DNA binding
FX986_RS03810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FX986_RS03825	COG1442	glycosyl transferase family 8
FX986_RS03835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FX986_RS03840	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FX986_RS03845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FX986_RS03850	COG2252	PERMEase
FX986_RS03855	COG0307	riboflavin synthase, alpha
FX986_RS03860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FX986_RS03865	COG2011	ABC-type metal ion transport system permease component
FX986_RS03870	COG1464	Belongs to the NlpA lipoprotein family
FX986_RS03875	COG1956	GAF domain-containing protein
FX986_RS03900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FX986_RS03905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FX986_RS03910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FX986_RS03915	COG2271	Major facilitator Superfamily
FX986_RS03920	COG1349	DNA-binding transcription factor activity
FX986_RS03940	COG1289	transmembrane transporter activity
FX986_RS03945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FX986_RS03955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FX986_RS03960	COG0776	regulation of translation
FX986_RS03970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FX986_RS03975	COG0733	neurotransmitter:sodium symporter activity
FX986_RS03980	COG0569	domain protein
FX986_RS03985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FX986_RS03990	COG0776	regulation of translation
FX986_RS03995	COG0072	phenylalanine-tRNA ligase activity
FX986_RS04000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FX986_RS04005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FX986_RS04010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FX986_RS04020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FX986_RS04025	COG2885	chlorophyll binding
FX986_RS04030	COG1473	amidohydrolase
FX986_RS04040	COG0297	glycogen (starch) synthase activity
FX986_RS04050	COG2194	sulfuric ester hydrolase activity
FX986_RS04060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FX986_RS04065	COG0471	metal ion transport
FX986_RS04070	COG0786	glutamate:sodium symporter activity
FX986_RS04075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FX986_RS04095	COG0583	DNA-binding transcription factor activity
FX986_RS04100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FX986_RS04105	COG0697	spore germination
FX986_RS04110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FX986_RS04115	COG1063	alcohol dehydrogenase
FX986_RS04125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FX986_RS04130	COG1846	Transcriptional regulator
FX986_RS04145	COG2154	pterin-4-alpha-carbinolamine dehydratase
FX986_RS04155	COG0583	DNA-binding transcription factor activity
FX986_RS04165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX986_RS04170	COG0534	Mate efflux family protein
FX986_RS04175	COG0583	DNA-binding transcription factor activity
FX986_RS04180	COG3706	GGDEF domain
FX986_RS04180	COG2203	Gaf domain
FX986_RS04180	COG5001	Diguanylate cyclase
FX986_RS04180	COG4251	negative regulation of phosphorylation
FX986_RS04185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FX986_RS04190	COG0602	queuosine metabolic process
FX986_RS04205	COG0523	cobalamin synthesis protein
FX986_RS04210	COG1979	alcohol dehydrogenase
FX986_RS04215	COG2130	NADP-dependent
FX986_RS04220	COG0583	DNA-binding transcription factor activity
FX986_RS04225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FX986_RS04235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FX986_RS04240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FX986_RS04245	COG0740	serine-type endopeptidase activity
FX986_RS04250	COG0544	peptidyl-prolyl cis-trans isomerase activity
FX986_RS04275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FX986_RS04280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FX986_RS04285	COG0215	cysteine-tRNA ligase activity
FX986_RS04290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FX986_RS04295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FX986_RS04300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FX986_RS04330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FX986_RS04335	COG1301	dicarboxylic acid transport
FX986_RS04345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FX986_RS04350	COG3123	guanosine phosphorylase activity
FX986_RS04355	COG0534	Mate efflux family protein
FX986_RS04370	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX986_RS04370	COG1024	Enoyl-CoA hydratase
FX986_RS04375	COG1024	Enoyl-CoA hydratase
FX986_RS04380	COG1960	acyl-CoA dehydrogenase activity
FX986_RS04395	COG0318	PFAM AMP-dependent synthetase and ligase
FX986_RS04405	COG1984	allophanate hydrolase subunit 2
FX986_RS04410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FX986_RS04415	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FX986_RS04445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FX986_RS04450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FX986_RS04460	COG1174	glycine betaine transport
FX986_RS04465	COG0517	IMP dehydrogenase activity
FX986_RS04465	COG1125	glycine betaine transport
FX986_RS04470	COG1960	acyl-CoA dehydrogenase activity
FX986_RS04475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FX986_RS04485	COG4770	biotin carboxylase activity
FX986_RS04495	COG2824	Alkylphosphonate utilization operon protein PhnA
FX986_RS04515	COG2855	membrane
FX986_RS04540	COG1414	Transcriptional regulator
FX986_RS04550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS04550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS04555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS04555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS04560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS04565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FX986_RS04570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX986_RS04595	COG2826	transposase and inactivated derivatives, IS30 family
FX986_RS04620	COG1414	Transcriptional regulator
FX986_RS04625	COG0697	spore germination
FX986_RS04650	COG0137	argininosuccinate synthase activity
FX986_RS04655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FX986_RS04660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FX986_RS04665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FX986_RS04670	COG3842	ATPase activity
FX986_RS04690	COG0322	excinuclease ABC activity
FX986_RS04715	COG2116	formate transmembrane transporter activity
FX986_RS04730	COG0442	prolyl-tRNA aminoacylation
FX986_RS04740	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FX986_RS04745	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FX986_RS04750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FX986_RS04755	COG1011	Hydrolase
FX986_RS04760	COG0494	nUDIX hydrolase
FX986_RS04770	COG0433	COG0433 Predicted ATPase
FX986_RS04780	COG0129	dihydroxy-acid dehydratase activity
FX986_RS04790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FX986_RS04800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FX986_RS04805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FX986_RS04810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FX986_RS04815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FX986_RS04825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FX986_RS04825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FX986_RS04830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FX986_RS04835	COG2261	transglycosylase associated protein
FX986_RS04845	COG1215	transferase activity, transferring glycosyl groups
FX986_RS04855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS04865	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FX986_RS04880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FX986_RS04885	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FX986_RS04890	COG4181	ATPase activity
FX986_RS04900	COG2326	polyphosphate kinase activity
FX986_RS04925	COG1366	Belongs to the anti-sigma-factor antagonist family
FX986_RS04935	COG0488	(ABC) transporter
FX986_RS04955	COG1560	Kdo2-lipid A biosynthetic process
FX986_RS04960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FX986_RS04965	COG1538	Outer membrane efflux protein
FX986_RS04985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FX986_RS04990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FX986_RS04995	COG0585	pseudouridine synthase activity
FX986_RS05000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FX986_RS05005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FX986_RS05010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FX986_RS05015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FX986_RS05065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FX986_RS05075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FX986_RS05105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FX986_RS05115	COG3447	MASE1 domain protein
FX986_RS05115	COG5002	protein histidine kinase activity
FX986_RS05115	COG5001	Diguanylate cyclase
FX986_RS05135	COG0837	glucose binding
FX986_RS05140	COG0676	glucose-6-phosphate 1-epimerase activity
FX986_RS05145	COG0166	Belongs to the GPI family
FX986_RS05150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FX986_RS05160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS05165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS05170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS05175	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FX986_RS05185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FX986_RS05190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FX986_RS05195	COG0730	response to heat
FX986_RS05200	COG0745	RESPONSE REGULATOR receiver
FX986_RS05215	COG0494	nUDIX hydrolase
FX986_RS05225	COG0579	oxidoreductase
FX986_RS05235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FX986_RS05240	COG2918	glutathione biosynthetic process
FX986_RS05245	COG2183	response to ionizing radiation
FX986_RS05250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FX986_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS05270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FX986_RS05275	COG0459	protein refolding
FX986_RS05295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FX986_RS05300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FX986_RS05320	COG0824	Thioesterase
FX986_RS05330	COG2974	May be involved in recombination
FX986_RS05340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FX986_RS05355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FX986_RS05360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FX986_RS05380	COG2986	histidine ammonia-lyase
FX986_RS05410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FX986_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FX986_RS05430	COG0393	Putative heavy-metal-binding
FX986_RS05455	COG0589	response to stress
FX986_RS05460	COG0659	secondary active sulfate transmembrane transporter activity
FX986_RS05475	COG2423	ornithine cyclodeaminase activity
FX986_RS05480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FX986_RS05485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FX986_RS05490	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS05500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FX986_RS05505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FX986_RS05510	COG1674	ftsk spoiiie
FX986_RS05515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FX986_RS05520	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FX986_RS05525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FX986_RS05530	COG0542	response to heat
FX986_RS05535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FX986_RS05555	COG0482	sulfurtransferase activity
FX986_RS05560	COG2915	High frequency lysogenization protein hflD homolog
FX986_RS05570	COG2850	peptidyl-arginine hydroxylation
FX986_RS05585	COG2224	Isocitrate lyase
FX986_RS05590	COG3133	Outer membrane lipoprotein
FX986_RS05615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FX986_RS05620	COG4135	transport system, permease component
FX986_RS05625	COG4134	Bacterial extracellular solute-binding protein
FX986_RS05635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FX986_RS05640	COG2814	Major facilitator Superfamily
FX986_RS05645	COG0583	DNA-binding transcription factor activity
FX986_RS05650	COG0791	NLP P60 protein
FX986_RS05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX986_RS05670	COG1309	transcriptional regulator
FX986_RS05675	COG2983	Belongs to the UPF0260 family
FX986_RS05680	COG3100	YcgL domain-containing protein
FX986_RS05690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FX986_RS05695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FX986_RS05700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FX986_RS05730	COG3264	Mechanosensitive ion channel
FX986_RS05730	COG1196	nuclear chromosome segregation
FX986_RS05740	COG4575	ribosome binding
FX986_RS05760	COG0583	DNA-binding transcription factor activity
FX986_RS05765	COG2081	HI0933 family
FX986_RS05775	COG0488	(ABC) transporter
FX986_RS05780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FX986_RS05810	COG0778	Nitroreductase
FX986_RS05815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FX986_RS05815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FX986_RS05820	COG0842	Transport permease protein
FX986_RS05825	COG1131	(ABC) transporter
FX986_RS05870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FX986_RS05875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FX986_RS05880	COG0436	Aminotransferase
FX986_RS05885	COG0501	Belongs to the peptidase M48B family
FX986_RS05890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FX986_RS05895	COG1757	Na H antiporter
FX986_RS05900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FX986_RS05915	COG0116	Belongs to the methyltransferase superfamily
FX986_RS05915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FX986_RS05920	COG3130	regulation of translation
FX986_RS05925	COG0167	dihydroorotate dehydrogenase activity
FX986_RS05935	COG2902	Dehydrogenase
FX986_RS05940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FX986_RS05945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FX986_RS05950	COG1522	sequence-specific DNA binding
FX986_RS05955	COG3608	succinylglutamate desuccinylase aspartoacylase
FX986_RS05960	COG0006	proline dipeptidase activity
FX986_RS05970	COG1522	sequence-specific DNA binding
FX986_RS05975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FX986_RS05980	COG0693	protein deglycase activity
FX986_RS05990	COG2431	L-lysine efflux transmembrane transporter activity
FX986_RS05995	COG1609	Transcriptional regulator
FX986_RS06005	COG2610	gluconate transmembrane transporter activity
FX986_RS06010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX986_RS06015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FX986_RS06020	COG2205	protein histidine kinase activity
FX986_RS06025	COG0745	RESPONSE REGULATOR receiver
FX986_RS06040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS06045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FX986_RS06045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FX986_RS06045	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FX986_RS06050	COG1105	Belongs to the carbohydrate kinase PfkB family
FX986_RS06060	COG1609	Transcriptional regulator
FX986_RS06080	COG0123	including yeast histone deacetylase and acetoin utilization protein
FX986_RS06085	COG3217	Mosc domain protein beta barrel domain protein
FX986_RS06085	COG0633	Ferredoxin
FX986_RS06095	COG4149	molybdate abc transporter
FX986_RS06100	COG0725	ABC transporter, periplasmic molybdate-binding protein
FX986_RS06105	COG0583	DNA-binding transcription factor activity
FX986_RS06110	COG0625	glutathione transferase activity
FX986_RS06120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FX986_RS06120	COG3153	acetyltransferase
FX986_RS06145	COG3040	lipid binding
FX986_RS06155	COG2988	succinylglutamate desuccinylase activity
FX986_RS06165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX986_RS06175	COG4160	amino acid transport
FX986_RS06180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX986_RS06225	COG3724	N-succinylarginine dihydrolase activity
FX986_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS06255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FX986_RS06275	COG1538	Outer membrane efflux protein
FX986_RS06285	COG2274	protein secretion by the type I secretion system
FX986_RS06375	COG0714	Associated with various cellular activities
FX986_RS06385	COG1960	acyl-CoA dehydrogenase activity
FX986_RS06405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FX986_RS06410	COG0343	queuine tRNA-ribosyltransferase activity
FX986_RS06415	COG1862	Preprotein translocase
FX986_RS06460	COG0105	UTP biosynthetic process
FX986_RS06465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FX986_RS06475	COG1426	Protein conserved in bacteria
FX986_RS06480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FX986_RS06485	COG0124	histidyl-tRNA synthetase
FX986_RS06490	COG2976	Protein conserved in bacteria
FX986_RS06500	COG1160	GTP binding
FX986_RS06515	COG1716	ATPase activity
FX986_RS06515	COG5001	Diguanylate cyclase
FX986_RS06535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FX986_RS06540	COG0408	coproporphyrinogen oxidase activity
FX986_RS06545	COG0009	L-threonylcarbamoyladenylate synthase
FX986_RS06555	COG0758	DNA mediated transformation
FX986_RS06560	COG1652	LysM domain
FX986_RS06565	COG0242	peptide deformylase activity
FX986_RS06570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FX986_RS06580	COG0569	domain protein
FX986_RS06585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FX986_RS06590	COG3148	PFAM DTW domain containing protein
FX986_RS06595	COG0385	Bile acid
FX986_RS06600	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FX986_RS06605	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FX986_RS06610	COG0037	tRNA processing
FX986_RS06620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FX986_RS06630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX986_RS06640	COG0784	Response regulator, receiver
FX986_RS06640	COG2198	Histidine kinase
FX986_RS06640	COG2205	protein histidine kinase activity
FX986_RS06650	COG0697	spore germination
FX986_RS06655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FX986_RS06660	COG3091	SprT-like family
FX986_RS06670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FX986_RS06675	COG2937	Belongs to the GPAT DAPAT family
FX986_RS06680	COG0742	ribosomal rna small subunit methyltransferase
FX986_RS06685	COG1968	undecaprenyl-diphosphatase activity
FX986_RS06690	COG1214	PFAM Peptidase M22, glycoprotease
FX986_RS06695	COG0563	adenylate kinase activity
FX986_RS06700	COG0861	Integral membrane protein TerC family
FX986_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS06745	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FX986_RS06750	COG0235	Class ii aldolase
FX986_RS06765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FX986_RS06770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FX986_RS06780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FX986_RS06785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FX986_RS06795	COG0425	Belongs to the sulfur carrier protein TusA family
FX986_RS06830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FX986_RS06835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FX986_RS06840	COG0180	Tryptophanyl-tRNA synthetase
FX986_RS06845	COG1061	Type III restriction enzyme res subunit
FX986_RS06850	COG1024	Enoyl-CoA hydratase
FX986_RS06855	COG0069	glutamate synthase activity
FX986_RS06865	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FX986_RS06880	COG1946	Acyl-CoA thioesterase
FX986_RS06915	COG1648	precorrin-2 dehydrogenase activity
FX986_RS06915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FX986_RS06920	COG0243	molybdopterin cofactor binding
FX986_RS06925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FX986_RS06930	COG2146	nitrite reductase [NAD(P)H] activity
FX986_RS06930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FX986_RS06935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FX986_RS06935	COG2146	nitrite reductase [NAD(P)H] activity
FX986_RS06945	COG0559	Belongs to the binding-protein-dependent transport system permease family
FX986_RS06965	COG1760	l-serine dehydratase
FX986_RS06970	COG0583	DNA-binding transcription factor activity
FX986_RS06990	COG0358	DNA primase activity
FX986_RS06995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FX986_RS07000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FX986_RS07005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FX986_RS07010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FX986_RS07015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FX986_RS07020	COG0617	tRNA 3'-terminal CCA addition
FX986_RS07025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FX986_RS07030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FX986_RS07035	COG2967	ApaG domain
FX986_RS07040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FX986_RS07050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FX986_RS07055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FX986_RS07060	COG3178	'Phosphotransferase
FX986_RS07065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FX986_RS07070	COG1765	OsmC-like protein
FX986_RS07075	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FX986_RS07080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FX986_RS07095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FX986_RS07100	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FX986_RS07105	COG0604	alcohol dehydrogenase
FX986_RS07130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FX986_RS07140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FX986_RS07145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FX986_RS07150	COG3706	GGDEF domain
FX986_RS07160	COG0534	Mate efflux family protein
FX986_RS07165	COG2031	fatty acid transporter
FX986_RS07170	COG1607	acyl-coa hydrolase
FX986_RS07175	COG2169	Transcriptional regulator
FX986_RS07175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FX986_RS07180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FX986_RS07190	COG0625	glutathione transferase activity
FX986_RS07205	COG2818	Glycosylase
FX986_RS07215	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FX986_RS07220	COG0511	ligase activity, forming carbon-carbon bonds
FX986_RS07220	COG5016	pyruvate
FX986_RS07250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FX986_RS07255	COG0527	aspartate kinase activity
FX986_RS07260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FX986_RS07265	COG2137	regulation of response to DNA damage stimulus
FX986_RS07270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FX986_RS07275	COG1546	Belongs to the CinA family
FX986_RS07280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FX986_RS07285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FX986_RS07290	COG0148	phosphopyruvate hydratase activity
FX986_RS07295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FX986_RS07300	COG0504	CTP synthase activity
FX986_RS07305	COG0493	'glutamate synthase
FX986_RS07310	COG0070	glutamate synthase
FX986_RS07310	COG0069	glutamate synthase activity
FX986_RS07310	COG0067	glutamate synthase
FX986_RS07315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FX986_RS07320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FX986_RS07360	COG0281	malic enzyme
FX986_RS07365	COG0254	rRNA binding
FX986_RS07370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FX986_RS07375	COG0018	arginyl-trna synthetase
FX986_RS07385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FX986_RS07390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FX986_RS07400	COG2226	methyltransferase
FX986_RS07410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FX986_RS07415	COG0140	phosphoribosyl-ATP diphosphatase activity
FX986_RS07420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FX986_RS07425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FX986_RS07435	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FX986_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS07480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FX986_RS07500	COG0037	tRNA processing
FX986_RS07505	COG0825	malonyl-CoA metabolic process
FX986_RS07515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FX986_RS07520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FX986_RS07525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FX986_RS07530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FX986_RS07535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FX986_RS07545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX986_RS07555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FX986_RS07565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FX986_RS07570	COG0233	cytoplasmic translational termination
FX986_RS07575	COG0528	UMP kinase activity
FX986_RS07580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FX986_RS07585	COG0052	Belongs to the universal ribosomal protein uS2 family
FX986_RS07600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FX986_RS07605	COG1393	Belongs to the ArsC family
FX986_RS07610	COG2171	N-acyltransferase activity
FX986_RS07615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FX986_RS07635	COG0492	ferredoxin-NADP+ reductase activity
FX986_RS07640	COG0450	alkyl hydroperoxide reductase
FX986_RS07660	COG2391	methyltransferase activity
FX986_RS07665	COG0180	Tryptophanyl-tRNA synthetase
FX986_RS07670	COG0686	Belongs to the AlaDH PNT family
FX986_RS07685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FX986_RS07695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FX986_RS07700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FX986_RS07705	COG2003	Belongs to the UPF0758 family
FX986_RS07710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FX986_RS07715	COG0756	dUTP diphosphatase activity
FX986_RS07725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FX986_RS07730	COG1309	transcriptional regulator
FX986_RS07745	COG2177	Part of the ABC transporter FtsEX involved in
FX986_RS07750	COG2884	Cell division ATP-binding protein ftsE
FX986_RS07755	COG0552	protein localization to endoplasmic reticulum
FX986_RS07760	COG0742	ribosomal rna small subunit methyltransferase
FX986_RS07770	COG0456	acetyltransferase
FX986_RS07770	COG0454	-acetyltransferase
FX986_RS07780	COG0271	Belongs to the BolA IbaG family
FX986_RS07790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FX986_RS07800	COG4166	transmembrane transport
FX986_RS07805	COG4166	transmembrane transport
FX986_RS07810	COG0601	transmembrane transport
FX986_RS07815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FX986_RS07820	COG4172	Belongs to the ABC transporter superfamily
FX986_RS07835	COG0789	Transcriptional regulator
FX986_RS07840	COG2217	Heavy metal translocating P-type atpase
FX986_RS07860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FX986_RS07875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FX986_RS07880	COG4974	Belongs to the 'phage' integrase family
FX986_RS07885	COG0335	large ribosomal subunit rRNA binding
FX986_RS07890	COG0336	Belongs to the RNA methyltransferase TrmD family
FX986_RS07895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FX986_RS07900	COG0228	four-way junction DNA binding
FX986_RS07905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FX986_RS07910	COG4137	Cytochrome C assembly protein
FX986_RS07915	COG4536	flavin adenine dinucleotide binding
FX986_RS07940	COG1025	Belongs to the peptidase M16 family
FX986_RS07945	COG2925	Exonuclease
FX986_RS07950	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FX986_RS07955	COG2894	cell division
FX986_RS07960	COG0850	regulation of cytokinetic process
FX986_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS07995	COG3118	belongs to the thioredoxin family
FX986_RS08000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FX986_RS08010	COG0589	response to stress
FX986_RS08015	COG1115	amino acid carrier protein
FX986_RS08020	COG0604	alcohol dehydrogenase
FX986_RS08020	COG3321	synthase
FX986_RS08035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FX986_RS08050	COG0733	neurotransmitter:sodium symporter activity
FX986_RS08080	COG0667	Aldo Keto reductase
FX986_RS08085	COG3238	Protein conserved in bacteria
FX986_RS08090	COG3022	response to hydroperoxide
FX986_RS08145	COG1183	phosphatidylcholine synthase activity
FX986_RS08150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FX986_RS08160	COG0440	acetolactate synthase activity
FX986_RS08165	COG0028	Belongs to the TPP enzyme family
FX986_RS08190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FX986_RS08190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FX986_RS08200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX986_RS08230	COG4969	Belongs to the N-Me-Phe pilin family
FX986_RS08265	COG4969	Belongs to the N-Me-Phe pilin family
FX986_RS08275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FX986_RS08280	COG1047	Peptidyl-prolyl cis-trans
FX986_RS08285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FX986_RS08290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FX986_RS08295	COG0196	riboflavin kinase activity
FX986_RS08300	COG0728	peptidoglycan biosynthetic process
FX986_RS08305	COG0268	Binds directly to 16S ribosomal RNA
FX986_RS08310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FX986_RS08315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FX986_RS08320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FX986_RS08325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FX986_RS08330	COG0142	geranyltranstransferase activity
FX986_RS08350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FX986_RS08355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FX986_RS08360	COG0564	pseudouridine synthase activity
FX986_RS08365	COG1090	epimerase
FX986_RS08370	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FX986_RS08375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FX986_RS08380	COG0789	Transcriptional regulator
FX986_RS08385	COG0415	Belongs to the DNA photolyase family
FX986_RS08395	COG0300	oxidoreductase activity
FX986_RS08410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FX986_RS08425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FX986_RS08450	COG0629	single-stranded DNA binding
FX986_RS08455	COG2814	Major facilitator Superfamily
FX986_RS08465	COG0203	ribosomal protein L17
FX986_RS08470	COG0202	RNA polymerase activity
FX986_RS08475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FX986_RS08480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FX986_RS08485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FX986_RS08490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FX986_RS08500	COG0200	Binds to the 23S rRNA
FX986_RS08505	COG1841	ribosomal large subunit assembly
FX986_RS08510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FX986_RS08515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FX986_RS08520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FX986_RS08525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FX986_RS08530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FX986_RS08535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FX986_RS08540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FX986_RS08545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FX986_RS08550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FX986_RS08555	COG0255	Belongs to the universal ribosomal protein uL29 family
FX986_RS08560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FX986_RS08565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FX986_RS08570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FX986_RS08575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FX986_RS08580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FX986_RS08585	COG0089	rRNA binding
FX986_RS08590	COG0088	Forms part of the polypeptide exit tunnel
FX986_RS08595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FX986_RS08600	COG0051	transcription antitermination factor activity, RNA binding
FX986_RS08605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FX986_RS08610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FX986_RS08615	COG0049	tRNA binding
FX986_RS08620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FX986_RS08625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FX986_RS08630	COG0085	RNA polymerase activity
FX986_RS08635	COG0222	ribosome binding
FX986_RS08640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FX986_RS08645	COG0081	regulation of translation
FX986_RS08650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FX986_RS08685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FX986_RS08720	COG1620	l-lactate permease
FX986_RS08725	COG2186	Transcriptional regulator
FX986_RS08745	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FX986_RS08750	COG0733	neurotransmitter:sodium symporter activity
FX986_RS08755	COG0339	signal peptide processing
FX986_RS08770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FX986_RS08790	COG1953	Uracil, thiamine, allantoin
FX986_RS08805	COG1451	nucleotide metabolic process
FX986_RS08810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FX986_RS08815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FX986_RS08820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FX986_RS08825	COG0126	phosphoglycerate kinase activity
FX986_RS08835	COG0023	Translation Initiation Factor
FX986_RS08855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS08885	COG1217	gtp-binding protein TYPA
FX986_RS08895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FX986_RS08920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FX986_RS08930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FX986_RS08935	COG0708	Exodeoxyribonuclease III
FX986_RS08940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FX986_RS08945	COG1561	YicC-like family, N-terminal region
FX986_RS08955	COG0270	DNA (cytosine-5-)-methyltransferase activity
FX986_RS08985	COG1764	response to oxidative stress
FX986_RS08990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS08995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS09005	COG2814	Major facilitator Superfamily
FX986_RS09010	COG0194	GDP metabolic process
FX986_RS09015	COG1758	RNA polymerase activity
FX986_RS09020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FX986_RS09040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FX986_RS09045	COG1289	transmembrane transporter activity
FX986_RS09070	COG3161	chorismate lyase activity
FX986_RS09075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FX986_RS09090	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FX986_RS09095	COG0704	Plays a role in the regulation of phosphate uptake
FX986_RS09100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FX986_RS09105	COG0581	inorganic phosphate transmembrane transporter activity
FX986_RS09110	COG0573	inorganic phosphate transmembrane transporter activity
FX986_RS09120	COG1607	acyl-coa hydrolase
FX986_RS09125	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FX986_RS09130	COG0210	DNA helicase
FX986_RS09135	COG1737	Transcriptional regulator
FX986_RS09145	COG0733	neurotransmitter:sodium symporter activity
FX986_RS09150	COG1801	Protein of unknown function DUF72
FX986_RS09165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FX986_RS09170	COG1349	DNA-binding transcription factor activity
FX986_RS09175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FX986_RS09180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FX986_RS09185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FX986_RS09190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FX986_RS09195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FX986_RS09200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FX986_RS09205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FX986_RS09215	COG0356	it plays a direct role in the translocation of protons across the membrane
FX986_RS09220	COG3312	ion transport
FX986_RS09225	COG1475	DNA binding
FX986_RS09230	COG1192	Involved in chromosome partitioning
FX986_RS09235	COG0357	Ribosomal RNA small subunit methyltransferase G
FX986_RS09240	COG0445	tRNA wobble uridine modification
FX986_RS09245	COG1126	abc transporter atp-binding protein
FX986_RS09250	COG0765	amino acid transport
FX986_RS09255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX986_RS09260	COG0316	Belongs to the HesB IscA family
FX986_RS09265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FX986_RS09270	COG0038	chloride channel
FX986_RS09275	COG1981	membrane
FX986_RS09285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FX986_RS09330	COG2197	response regulator
FX986_RS09335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FX986_RS09340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FX986_RS09345	COG2885	chlorophyll binding
FX986_RS09350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FX986_RS09355	COG1132	(ABC) transporter
FX986_RS09360	COG1132	(ABC) transporter
FX986_RS09365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FX986_RS09370	COG0706	membrane insertase activity
FX986_RS09375	COG0594	ribonuclease P activity
FX986_RS09380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FX986_RS09385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FX986_RS09390	COG0592	DNA-directed DNA polymerase activity
FX986_RS09395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FX986_RS09415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FX986_RS09420	COG0751	glycine-tRNA ligase activity
FX986_RS09425	COG0752	glycyl-tRNA synthetase alpha subunit
FX986_RS09430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FX986_RS09445	COG0438	transferase activity, transferring glycosyl groups
FX986_RS09455	COG3642	lipopolysaccharide core region biosynthetic process
FX986_RS09460	COG0859	PFAM glycosyl transferase family 9
FX986_RS09465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FX986_RS09465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FX986_RS09470	COG1519	Transferase
FX986_RS09475	COG1349	DNA-binding transcription factor activity
FX986_RS09480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FX986_RS09495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FX986_RS09500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FX986_RS09505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FX986_RS09525	COG0006	proline dipeptidase activity
FX986_RS09530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FX986_RS09535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FX986_RS09540	COG0793	Belongs to the peptidase S41A family
FX986_RS09545	COG4942	peptidase
FX986_RS09550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FX986_RS09555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FX986_RS09560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FX986_RS09565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FX986_RS09570	COG0189	ligase activity
FX986_RS09580	COG1678	Uncharacterized ACR, COG1678
FX986_RS09585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FX986_RS09590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FX986_RS09595	COG0540	Belongs to the ATCase OTCase family
FX986_RS09605	COG1942	4-Oxalocrotonate Tautomerase
FX986_RS09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FX986_RS09615	COG1722	exodeoxyribonuclease VII activity
FX986_RS09620	COG0142	geranyltranstransferase activity
FX986_RS09625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FX986_RS09630	COG0625	glutathione transferase activity
FX986_RS09640	COG1272	protein, Hemolysin III
FX986_RS09645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FX986_RS09650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FX986_RS09660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FX986_RS09665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FX986_RS09670	COG4597	amino acid ABC transporter
FX986_RS09675	COG0765	amino acid transport
FX986_RS09680	COG1126	abc transporter atp-binding protein
FX986_RS09695	COG0583	DNA-binding transcription factor activity
FX986_RS09710	COG0004	ammonium transporteR
FX986_RS09735	COG0606	chelatase, subunit chli
FX986_RS09745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FX986_RS09760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FX986_RS09770	COG2363	Small membrane protein
FX986_RS09785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FX986_RS09790	COG2226	methyltransferase
FX986_RS09805	COG1999	signal sequence binding
FX986_RS09810	COG0545	Peptidyl-prolyl cis-trans isomerase
FX986_RS09820	COG0488	(ABC) transporter
FX986_RS09830	COG3321	synthase
FX986_RS09830	COG0604	alcohol dehydrogenase
FX986_RS09835	COG1238	metal cluster binding
FX986_RS09850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS09855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS09860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS09865	COG1490	D-aminoacyl-tRNA deacylase activity
FX986_RS09870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FX986_RS09875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS09900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FX986_RS09910	COG1011	Hydrolase
FX986_RS09915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FX986_RS09925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FX986_RS09930	COG0019	diaminopimelate decarboxylase activity
FX986_RS09940	COG0165	Argininosuccinate lyase
FX986_RS09945	COG0181	hydroxymethylbilane synthase activity
FX986_RS09955	COG2959	enzyme of heme biosynthesis
FX986_RS09970	COG0668	transmembrane transport
FX986_RS09975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FX986_RS09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FX986_RS09985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FX986_RS09990	COG1120	ATPase activity
FX986_RS10000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FX986_RS10005	COG2867	negative regulation of translational initiation
FX986_RS10015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FX986_RS10025	COG0497	DNA recombination
FX986_RS10030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FX986_RS10035	COG0443	Heat shock 70 kDa protein
FX986_RS10040	COG0484	heat shock protein binding
FX986_RS10050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FX986_RS10080	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FX986_RS10085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FX986_RS10090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FX986_RS10095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FX986_RS10100	COG0149	triose-phosphate isomerase activity
FX986_RS10105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FX986_RS10120	COG0779	Required for maturation of 30S ribosomal subunits
FX986_RS10125	COG0195	Participates in both transcription termination and antitermination
FX986_RS10130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FX986_RS10135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FX986_RS10140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FX986_RS10145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FX986_RS10150	COG1185	polyribonucleotide nucleotidyltransferase activity
FX986_RS10160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FX986_RS10165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FX986_RS10170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FX986_RS10180	COG0617	tRNA 3'-terminal CCA addition
FX986_RS10190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FX986_RS10195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FX986_RS10200	COG0436	Aminotransferase
FX986_RS10205	COG1489	DNA binding
FX986_RS10220	COG1607	acyl-coa hydrolase
FX986_RS10225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FX986_RS10225	COG2813	Specifically methylates the guanine in position
FX986_RS10230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FX986_RS10260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FX986_RS10265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FX986_RS10285	COG0346	lactoylglutathione lyase activity
FX986_RS10290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FX986_RS10295	COG1902	pentaerythritol trinitrate reductase activity
FX986_RS10320	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FX986_RS10335	COG3068	Protein conserved in bacteria
FX986_RS10345	COG0107	imidazoleglycerol-phosphate synthase activity
FX986_RS10350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FX986_RS10355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FX986_RS10360	COG0131	Imidazoleglycerol-phosphate dehydratase
FX986_RS10375	COG1194	a g-specific adenine glycosylase
FX986_RS10380	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FX986_RS10410	COG2204	response regulator
FX986_RS10425	COG1462	curli production assembly transport component CsgG
FX986_RS10430	COG5285	phytanoyl-CoA dioxygenase
FX986_RS10435	COG0179	Fumarylacetoacetate (FAA) hydrolase
FX986_RS10440	COG1166	arginine decarboxylase activity
FX986_RS10465	COG2204	response regulator
FX986_RS10470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FX986_RS10480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS10490	COG2175	clavaminate synthase activity
FX986_RS10525	COG0672	)-iron permease
FX986_RS10540	COG1444	tRNA N-acetyltransferase activity
FX986_RS10545	COG2195	Cleaves the N-terminal amino acid of tripeptides
FX986_RS10555	COG0693	protein deglycase activity
FX986_RS10570	COG3220	belongs to the UPF0276 family
FX986_RS10590	COG0783	Belongs to the Dps family
FX986_RS10595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS10610	COG4191	Histidine kinase
FX986_RS10670	COG0583	DNA-binding transcription factor activity
FX986_RS10675	COG1054	Belongs to the UPF0176 family
FX986_RS10685	COG0243	molybdopterin cofactor binding
FX986_RS10690	COG0346	lactoylglutathione lyase activity
FX986_RS10695	COG3706	GGDEF domain
FX986_RS10700	COG0671	phosphoesterase, PA-phosphatase related
FX986_RS10710	COG0525	valine-tRNA ligase activity
FX986_RS10715	COG2205	protein histidine kinase activity
FX986_RS10725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FX986_RS10730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FX986_RS10735	COG0795	lipopolysaccharide-transporting ATPase activity
FX986_RS10740	COG0795	lipopolysaccharide-transporting ATPase activity
FX986_RS10780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FX986_RS10795	COG3220	belongs to the UPF0276 family
FX986_RS10810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FX986_RS10825	COG3278	Belongs to the heme-copper respiratory oxidase family
FX986_RS10865	COG0446	pyridine nucleotide-disulphide oxidoreductase
FX986_RS10865	COG1902	pentaerythritol trinitrate reductase activity
FX986_RS10880	COG2766	serine protein kinase
FX986_RS10885	COG2718	Belongs to the UPF0229 family
FX986_RS10890	COG2719	SpoVR family
FX986_RS10925	COG0557	exoribonuclease II activity
FX986_RS10930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FX986_RS10935	COG0360	Binds together with S18 to 16S ribosomal RNA
FX986_RS10940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FX986_RS10950	COG0359	binds to the 23S rRNA
FX986_RS10955	COG0305	Participates in initiation and elongation during chromosome replication
FX986_RS10965	COG2203	Gaf domain
FX986_RS10965	COG2199	diguanylate cyclase activity
FX986_RS10965	COG2200	EAL domain
FX986_RS10980	COG3046	protein related to deoxyribodipyrimidine photolyase
FX986_RS10985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FX986_RS10990	COG1320	monovalent cation:proton antiporter activity
FX986_RS10995	COG2212	antiporter activity
FX986_RS11000	COG1863	multisubunit Na H antiporter MnhE subunit
FX986_RS11005	COG0651	ATP synthesis coupled electron transport
FX986_RS11010	COG1006	Multisubunit Na H antiporter MnhC subunit
FX986_RS11015	COG2111	Na H antiporter
FX986_RS11015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FX986_RS11020	COG0415	Belongs to the DNA photolyase family
FX986_RS11035	COG0151	Belongs to the GarS family
FX986_RS11045	COG3954	Phosphoribulokinase
FX986_RS11055	COG0537	adenosine 5'-monophosphoramidase activity
FX986_RS11060	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FX986_RS11085	COG2205	protein histidine kinase activity
FX986_RS11090	COG0666	response to abiotic stimulus
FX986_RS11105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FX986_RS11110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FX986_RS11115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FX986_RS11115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FX986_RS11120	COG0745	RESPONSE REGULATOR receiver
FX986_RS11125	COG2205	protein histidine kinase activity
FX986_RS11135	COG1278	Cold shock
FX986_RS11140	COG0583	DNA-binding transcription factor activity
FX986_RS11155	COG1739	Uncharacterized protein family UPF0029
FX986_RS11160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FX986_RS11185	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FX986_RS11190	COG1138	Cytochrome C-type biogenesis protein
FX986_RS11195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FX986_RS11215	COG3115	cell septum assembly
FX986_RS11220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FX986_RS11235	COG3290	protein histidine kinase activity
FX986_RS11240	COG4565	transcriptional regulatory protein
FX986_RS11245	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FX986_RS11245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX986_RS11250	COG2350	Protein conserved in bacteria
FX986_RS11255	COG2917	probably involved in intracellular septation
FX986_RS11260	COG0613	PHP domain protein
FX986_RS11265	COG0009	L-threonylcarbamoyladenylate synthase
FX986_RS11275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FX986_RS11285	COG1392	Phosphate transport regulator
FX986_RS11290	COG0306	phosphate transporter
FX986_RS11295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FX986_RS11295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FX986_RS11305	COG2205	protein histidine kinase activity
FX986_RS11315	COG2204	response regulator
FX986_RS11340	COG0745	RESPONSE REGULATOR receiver
FX986_RS11345	COG0642	Histidine kinase
FX986_RS11360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FX986_RS11360	COG0519	Catalyzes the synthesis of GMP from XMP
FX986_RS11375	COG0564	pseudouridine synthase activity
FX986_RS11380	COG0492	ferredoxin-NADP+ reductase activity
FX986_RS11390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FX986_RS11415	COG0513	Belongs to the DEAD box helicase family
FX986_RS11430	COG2223	nitrite transmembrane transporter activity
FX986_RS11440	COG1116	anion transmembrane transporter activity
FX986_RS11440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FX986_RS11445	COG1309	transcriptional regulator
FX986_RS11470	COG1953	Uracil, thiamine, allantoin
FX986_RS11475	COG0583	DNA-binding transcription factor activity
FX986_RS11495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FX986_RS11510	COG1902	pentaerythritol trinitrate reductase activity
FX986_RS11510	COG0446	pyridine nucleotide-disulphide oxidoreductase
FX986_RS11515	COG2181	nitrate reductase activity
FX986_RS11515	COG0247	lactate metabolic process
FX986_RS11520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FX986_RS11540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS11550	COG3383	formate dehydrogenase (NAD+) activity
FX986_RS11560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FX986_RS11565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FX986_RS11570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FX986_RS11575	COG1845	cytochrome c oxidase, subunit III
FX986_RS11580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FX986_RS11585	COG0109	protoheme IX farnesyltransferase activity
FX986_RS11595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FX986_RS11595	COG1017	nitric oxide dioxygenase activity
FX986_RS11600	COG1757	Na H antiporter
FX986_RS11610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FX986_RS11650	COG1120	ATPase activity
FX986_RS11665	COG3486	L-lysine 6-monooxygenase (NADPH) activity
FX986_RS11670	COG0076	glutamate decarboxylase activity
FX986_RS11715	COG0739	heme binding
FX986_RS11720	COG0583	DNA-binding transcription factor activity
FX986_RS11725	COG0435	Glutathione S-transferase
FX986_RS11730	COG1671	Belongs to the UPF0178 family
FX986_RS11745	COG1515	deoxyribonuclease V activity
FX986_RS11755	COG0420	3'-5' exonuclease activity
FX986_RS11770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FX986_RS11775	COG1074	ATP-dependent DNA helicase activity
FX986_RS11780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FX986_RS11790	COG2205	protein histidine kinase activity
FX986_RS11795	COG1914	H( )-stimulated, divalent metal cation uptake system
FX986_RS11840	COG3104	oligopeptide transport
FX986_RS11845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FX986_RS11850	COG1309	transcriptional regulator
FX986_RS11865	COG0583	DNA-binding transcription factor activity
FX986_RS11875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FX986_RS11880	COG4988	ABC transporter
FX986_RS11885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FX986_RS11900	COG2084	Dehydrogenase
FX986_RS11915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FX986_RS11920	COG1053	succinate dehydrogenase
FX986_RS11945	COG0045	succinate-CoA ligase (ADP-forming) activity
FX986_RS11960	COG0584	glycerophosphoryl diester phosphodiesterase
FX986_RS11975	COG0438	transferase activity, transferring glycosyl groups
FX986_RS11985	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FX986_RS11995	COG0673	inositol 2-dehydrogenase activity
FX986_RS12000	COG3768	UPF0283 membrane protein
FX986_RS12005	COG3106	COG3106 Predicted ATPase
FX986_RS12010	COG2814	Major facilitator Superfamily
FX986_RS12020	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX986_RS12025	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FX986_RS12070	COG0121	glutamine amidotransferase
FX986_RS12080	COG0318	PFAM AMP-dependent synthetase and ligase
FX986_RS12085	COG1643	Atp-dependent helicase
FX986_RS12095	COG2853	Lipoprotein
FX986_RS12115	COG2814	Major facilitator Superfamily
FX986_RS12125	COG0573	inorganic phosphate transmembrane transporter activity
FX986_RS12130	COG0573	inorganic phosphate transmembrane transporter activity
FX986_RS12135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FX986_RS12140	COG0183	Belongs to the thiolase family
FX986_RS12145	COG1309	transcriptional regulator
FX986_RS12150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FX986_RS12160	COG1960	acyl-CoA dehydrogenase activity
FX986_RS12165	COG0628	permease
FX986_RS12170	COG3118	belongs to the thioredoxin family
FX986_RS12175	COG0730	response to heat
FX986_RS12180	COG0583	DNA-binding transcription factor activity
FX986_RS12185	COG0175	sulfate reduction
FX986_RS12200	COG1802	Transcriptional regulator
FX986_RS12205	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FX986_RS12210	COG0372	Belongs to the citrate synthase family
FX986_RS12215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FX986_RS12225	COG2079	MmgE PrpD family protein
FX986_RS12230	COG1704	LemA family
FX986_RS12235	COG0501	Belongs to the peptidase M48B family
FX986_RS12255	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FX986_RS12280	COG3101	peptidyl-lysine hydroxylation
FX986_RS12285	COG1840	ABC-type Fe3 transport system, periplasmic component
FX986_RS12300	COG0513	Belongs to the DEAD box helicase family
FX986_RS12315	COG0488	(ABC) transporter
FX986_RS12320	COG0589	response to stress
FX986_RS12330	COG1846	Transcriptional regulator
FX986_RS12340	COG1250	3-hydroxyacyl-CoA dehydrogenase
FX986_RS12340	COG1024	Enoyl-CoA hydratase
FX986_RS12345	COG0183	Belongs to the thiolase family
FX986_RS12360	COG1466	dna polymerase III delta subunit
FX986_RS12370	COG0495	leucyl-tRNA aminoacylation
FX986_RS12395	COG4535	Mg2 and Co2 transporter CorC
FX986_RS12400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FX986_RS12405	COG1702	phosphate starvation-inducible protein PhoH
FX986_RS12410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FX986_RS12415	COG4991	sh3 domain protein
FX986_RS12420	COG0500	methyltransferase
FX986_RS12435	COG0405	Gamma-glutamyltransferase
FX986_RS12440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FX986_RS12445	COG2827	Endonuclease containing a URI domain
FX986_RS12450	COG1252	NADH dehydrogenase
FX986_RS12455	COG0546	phosphoglycolate phosphatase activity
FX986_RS12470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FX986_RS12475	COG0134	indole-3-glycerol-phosphate synthase activity
FX986_RS12485	COG1349	DNA-binding transcription factor activity
FX986_RS12490	COG0584	glycerophosphoryl diester phosphodiesterase
FX986_RS12495	COG3842	ATPase activity
FX986_RS12500	COG0395	ABC-type sugar transport system, permease component
FX986_RS12505	COG1175	transmembrane transport
FX986_RS12530	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FX986_RS12540	COG1309	transcriptional regulator
FX986_RS12575	COG1362	aminopeptidase activity
FX986_RS12590	COG0583	DNA-binding transcription factor activity
FX986_RS12600	COG0193	aminoacyl-tRNA hydrolase activity
FX986_RS12605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FX986_RS12620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FX986_RS12625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FX986_RS12635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FX986_RS12640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FX986_RS12645	COG2890	protein-(glutamine-N5) methyltransferase activity
FX986_RS12655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FX986_RS12660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX986_RS12665	COG3842	ATPase activity
FX986_RS12670	COG1176	ABC-type spermidine putrescine transport system, permease component I
FX986_RS12675	COG1177	transmembrane transport
FX986_RS12690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FX986_RS12695	COG0174	glutamine synthetase
FX986_RS12700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FX986_RS12705	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS12715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FX986_RS12720	COG0154	amidase activity
FX986_RS12725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FX986_RS12730	COG1077	Cell shape determining protein MreB Mrl
FX986_RS12735	COG1792	Involved in formation and maintenance of cell shape
FX986_RS12740	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FX986_RS12745	COG0424	maF-like protein
FX986_RS12750	COG1530	ribonuclease E activity
FX986_RS12760	COG0312	modulator of DNA gyrase
FX986_RS12765	COG3028	Belongs to the UPF0307 family
FX986_RS12770	COG0312	modulator of DNA gyrase
FX986_RS12775	COG2239	Acts as a magnesium transporter
FX986_RS12780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FX986_RS12785	COG1660	Displays ATPase and GTPase activities
FX986_RS12800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FX986_RS12805	COG1137	ATPase activity
FX986_RS12810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FX986_RS12820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FX986_RS12835	COG1127	ABC transporter
FX986_RS12840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FX986_RS12845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FX986_RS12860	COG5007	Belongs to the BolA IbaG family
FX986_RS12865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FX986_RS12870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FX986_RS12875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FX986_RS12880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FX986_RS12895	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FX986_RS12900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FX986_RS12905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FX986_RS12910	COG0723	plastoquinol--plastocyanin reductase activity
FX986_RS12915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FX986_RS12920	COG2857	Cytochrome c1
FX986_RS12925	COG0625	glutathione transferase activity
FX986_RS12930	COG2969	positive regulation of protein catabolic process
FX986_RS12935	COG2823	Periplasmic or secreted lipoprotein
FX986_RS12940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FX986_RS12945	COG0792	nuclease activity
FX986_RS12965	COG0275	rRNA processing
FX986_RS12985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FX986_RS12990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FX986_RS12995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FX986_RS13000	COG0772	Belongs to the SEDS family
FX986_RS13005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FX986_RS13010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FX986_RS13015	COG1181	Belongs to the D-alanine--D-alanine ligase family
FX986_RS13035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FX986_RS13050	COG0653	protein targeting
FX986_RS13055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FX986_RS13060	COG0352	thiamine-phosphate diphosphorylase activity
FX986_RS13070	COG0237	dephospho-CoA kinase activity
FX986_RS13100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FX986_RS13110	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FX986_RS13110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FX986_RS13115	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FX986_RS13120	COG1737	Transcriptional regulator
FX986_RS13145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FX986_RS13155	COG2040	homocysteine
FX986_RS13160	COG0653	protein targeting
FX986_RS13175	COG1215	transferase activity, transferring glycosyl groups
FX986_RS13180	COG2244	polysaccharide biosynthetic process
FX986_RS13205	COG2814	Major facilitator Superfamily
FX986_RS13215	COG1047	Peptidyl-prolyl cis-trans
FX986_RS13225	COG0284	orotidine-5'-phosphate decarboxylase activity
FX986_RS13240	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FX986_RS13245	COG4206	TonB-dependent receptor
FX986_RS13250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FX986_RS13260	COG0277	FAD linked oxidase domain protein
FX986_RS13260	COG0247	lactate metabolic process
FX986_RS13270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FX986_RS13275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FX986_RS13280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FX986_RS13280	COG1648	precorrin-2 dehydrogenase activity
FX986_RS13285	COG1960	acyl-CoA dehydrogenase activity
FX986_RS13295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FX986_RS13300	COG1742	UPF0060 membrane protein
FX986_RS13315	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FX986_RS13320	COG2226	methyltransferase
FX986_RS13320	COG1073	alpha beta
FX986_RS13325	COG0596	Alpha beta hydrolase
FX986_RS13330	COG0156	8-amino-7-oxononanoate synthase activity
FX986_RS13335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FX986_RS13345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FX986_RS13350	COG0302	gtp cyclohydrolase
FX986_RS13355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FX986_RS13385	COG0138	bifunctional purine biosynthesis protein purh
FX986_RS13400	COG2264	protein methyltransferase activity
FX986_RS13410	COG0511	ligase activity, forming carbon-carbon bonds
FX986_RS13415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FX986_RS13440	COG0205	6-phosphofructokinase activity
FX986_RS13445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FX986_RS13465	COG0586	Pfam SNARE associated Golgi protein
FX986_RS13480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FX986_RS13485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FX986_RS13495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FX986_RS13500	COG0768	penicillin binding
FX986_RS13505	COG0772	Belongs to the SEDS family
FX986_RS13510	COG2951	lytic endotransglycosylase activity
FX986_RS13515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FX986_RS13520	COG1686	Belongs to the peptidase S11 family
FX986_RS13525	COG2921	Belongs to the UPF0250 family
FX986_RS13530	COG0321	lipoyl(octanoyl) transferase activity
FX986_RS13535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FX986_RS13545	COG0439	Biotin carboxylase
FX986_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS13575	COG1803	Methylglyoxal synthase
FX986_RS13580	COG0469	pyruvate kinase activity
FX986_RS13600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FX986_RS13605	COG1309	transcriptional regulator
FX986_RS13610	COG1376	ErfK ybiS ycfS ynhG family protein
FX986_RS13615	COG1472	Belongs to the glycosyl hydrolase 3 family
FX986_RS13620	COG0668	transmembrane transport
FX986_RS13625	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FX986_RS13635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FX986_RS13645	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FX986_RS13650	COG1805	sodium ion transport
FX986_RS13665	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FX986_RS13670	COG2871	sodium ion transport
FX986_RS13675	COG1477	protein flavinylation
FX986_RS13685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FX986_RS13700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FX986_RS13710	COG4591	ABC-type transport system involved in lipoprotein release permease component
FX986_RS13715	COG1136	(ABC) transporter
FX986_RS13730	COG0811	peptide transport
FX986_RS13735	COG0848	biopolymer transport protein
FX986_RS13740	COG1132	(ABC) transporter
FX986_RS13745	COG1663	tetraacyldisaccharide 4'-kinase activity
FX986_RS13750	COG2835	tetraacyldisaccharide 4'-kinase activity
FX986_RS13755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FX986_RS13765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FX986_RS13770	COG1530	ribonuclease E activity
FX986_RS13780	COG0546	phosphoglycolate phosphatase activity
FX986_RS13785	COG0616	signal peptide processing
FX986_RS13785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FX986_RS13790	COG0424	maF-like protein
FX986_RS13795	COG1399	metal-binding, possibly nucleic acid-binding protein
FX986_RS13800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FX986_RS13805	COG0416	fatty acid biosynthetic process
FX986_RS13810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FX986_RS13820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FX986_RS13825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FX986_RS13830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FX986_RS13835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FX986_RS13840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FX986_RS13855	COG0084	hydrolase, TatD family'
FX986_RS13865	COG0210	DNA helicase
FX986_RS13875	COG1301	dicarboxylic acid transport
FX986_RS13910	COG0848	biopolymer transport protein
FX986_RS13925	COG0708	Exodeoxyribonuclease III
FX986_RS13940	COG1199	ATP-dependent helicase activity
FX986_RS13945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FX986_RS13960	COG4628	conserved protein (DUF2132)
FX986_RS13970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FX986_RS13975	COG0481	GTPase activity
FX986_RS13985	COG0571	ribonuclease III activity
FX986_RS13990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FX986_RS14005	COG0736	holo-[acyl-carrier-protein] synthase activity
FX986_RS14010	COG5002	protein histidine kinase activity
FX986_RS14010	COG2205	protein histidine kinase activity
FX986_RS14010	COG0784	Response regulator, receiver
FX986_RS14020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FX986_RS14025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FX986_RS14030	COG3956	TIGRFAM MazG family protein
FX986_RS14035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FX986_RS14040	COG0252	asparaginase activity
FX986_RS14045	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FX986_RS14060	COG2807	transmembrane transport
FX986_RS14090	COG3134	Outer membrane lipoprotein
FX986_RS14100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FX986_RS14100	COG3008	intermembrane lipid transfer
FX986_RS14105	COG2995	paraquat-inducible protein a
FX986_RS14115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX986_RS14120	COG0003	Pfam Anion-transporting ATPase
FX986_RS14130	COG1966	Carbon starvation protein
FX986_RS14135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FX986_RS14135	COG1565	acr, cog1565
FX986_RS14145	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FX986_RS14185	COG2814	Major facilitator Superfamily
FX986_RS14190	COG1597	lipid kinase activity
FX986_RS14200	COG0330	HflC and HflK could
FX986_RS14215	COG1278	Cold shock
FX986_RS14240	COG3932	Exopolysaccharide synthesis, ExoD
FX986_RS14245	COG1280	lysine exporter protein (LysE YggA)
FX986_RS14260	COG0741	lytic transglycosylase activity
FX986_RS14265	COG3339	Conserved Protein
FX986_RS14285	COG0326	Molecular chaperone. Has ATPase activity
FX986_RS14300	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FX986_RS14310	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FX986_RS14320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FX986_RS14340	COG1131	(ABC) transporter
FX986_RS14360	COG0596	Alpha beta hydrolase
FX986_RS14380	COG1193	negative regulation of DNA recombination
FX986_RS14390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FX986_RS14405	COG3243	poly(R)-hydroxyalkanoic acid synthase
FX986_RS14415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FX986_RS14420	COG0066	3-isopropylmalate dehydratase activity
FX986_RS14425	COG0473	3-isopropylmalate dehydrogenase activity
FX986_RS14440	COG0101	tRNA pseudouridine synthase activity
FX986_RS14445	COG0135	phosphoribosylanthranilate isomerase activity
FX986_RS14450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FX986_RS14455	COG0285	dihydrofolate synthase activity
FX986_RS14480	COG3038	cytochrome b561
FX986_RS14485	COG2353	YceI-like domain
FX986_RS14490	COG1280	lysine exporter protein (LysE YggA)
FX986_RS14510	COG1215	transferase activity, transferring glycosyl groups
FX986_RS14520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FX986_RS14525	COG2056	Na+-H+ antiporter family
FX986_RS14535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FX986_RS14555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FX986_RS14580	COG0189	ligase activity
FX986_RS14590	COG1666	GTP binding
FX986_RS14595	COG2996	Protein conserved in bacteria
FX986_RS14600	COG1929	Belongs to the glycerate kinase type-1 family
FX986_RS14610	COG0308	aminopeptidase N
FX986_RS14615	COG1162	GTPase activity
FX986_RS14620	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FX986_RS14630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FX986_RS14630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FX986_RS14635	COG0802	atpase or kinase
FX986_RS14640	COG0860	N-Acetylmuramoyl-L-alanine amidase
FX986_RS14645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FX986_RS14650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FX986_RS14655	COG1923	regulation of RNA biosynthetic process
FX986_RS14660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FX986_RS14665	COG0330	HflC and HflK could
FX986_RS14670	COG0330	HflC and HflK could
FX986_RS14675	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FX986_RS14680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FX986_RS14685	COG1959	2 iron, 2 sulfur cluster binding
FX986_RS14690	COG0719	Fe-S assembly protein
FX986_RS14695	COG0396	ATPase activity
FX986_RS14700	COG0719	Fe-S assembly protein
FX986_RS14730	COG0189	ligase activity
FX986_RS14735	COG4067	protein conserved in archaea
FX986_RS14735	COG0189	ligase activity
FX986_RS14755	COG1126	abc transporter atp-binding protein
FX986_RS14805	COG0400	carboxylic ester hydrolase activity
FX986_RS14820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FX986_RS14830	COG3047	cAMP biosynthetic process
FX986_RS14850	COG1294	oxidase, subunit
FX986_RS14855	COG4890	Cyd operon protein YbgT
FX986_RS14865	COG0463	Glycosyl transferase, family 2
FX986_RS14885	COG0668	transmembrane transport
FX986_RS14915	COG1414	Transcriptional regulator
FX986_RS14945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FX986_RS14955	COG1280	lysine exporter protein (LysE YggA)
FX986_RS14980	COG1653	transport
FX986_RS14985	COG1175	transmembrane transport
FX986_RS14995	COG3842	ATPase activity
FX986_RS15000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FX986_RS15015	COG1070	Carbohydrate kinase
FX986_RS15020	COG0667	Aldo Keto reductase
FX986_RS15030	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FX986_RS15035	COG0247	lactate metabolic process
FX986_RS15040	COG0277	FAD linked oxidase domain protein
FX986_RS15045	COG0277	FAD linked oxidase domain protein
FX986_RS15050	COG2186	Transcriptional regulator
FX986_RS15060	COG3048	D-serine ammonia-lyase activity
FX986_RS15065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FX986_RS15065	COG0617	tRNA 3'-terminal CCA addition
FX986_RS15065	COG0517	IMP dehydrogenase activity
FX986_RS15075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FX986_RS15075	COG0678	peroxiredoxin activity
FX986_RS15090	COG3842	ATPase activity
FX986_RS15100	COG1176	ABC-type spermidine putrescine transport system, permease component I
FX986_RS15110	COG3284	Transcriptional regulator
FX986_RS15115	COG3842	ATPase activity
FX986_RS15120	COG3842	ATPase activity
FX986_RS15130	COG0395	ABC-type sugar transport system, permease component
FX986_RS15150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FX986_RS15150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FX986_RS15155	COG0509	glycine decarboxylation via glycine cleavage system
FX986_RS15160	COG1115	amino acid carrier protein
FX986_RS15165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FX986_RS15170	COG1278	Cold shock
FX986_RS15175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FX986_RS15180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FX986_RS15185	COG0583	DNA-binding transcription factor activity
FX986_RS15240	COG2855	membrane
FX986_RS15245	COG0583	DNA-binding transcription factor activity
FX986_RS15250	COG0596	Alpha beta hydrolase
FX986_RS15260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FX986_RS15265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FX986_RS15270	COG1116	anion transmembrane transporter activity
FX986_RS15280	COG3263	regulation of cellular component size
FX986_RS15285	COG3706	GGDEF domain
FX986_RS15290	COG0513	Belongs to the DEAD box helicase family
FX986_RS15310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FX986_RS15315	COG2923	Belongs to the DsrF TusC family
FX986_RS15330	COG0217	transcriptional regulatory protein
FX986_RS15340	COG0189	ligase activity
FX986_RS15340	COG4067	protein conserved in archaea
FX986_RS15355	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FX986_RS15395	COG1764	response to oxidative stress
FX986_RS15400	COG1295	ribonuclease BN
FX986_RS15405	COG2962	Rard protein
FX986_RS15420	COG1187	pseudouridine synthase activity
FX986_RS15430	COG1301	dicarboxylic acid transport
FX986_RS15435	COG1794	racemase activity, acting on amino acids and derivatives
FX986_RS15440	COG0583	DNA-binding transcription factor activity
FX986_RS15500	COG2826	transposase and inactivated derivatives, IS30 family
FX986_RS15530	COG3284	Transcriptional regulator
FX986_RS15590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS15610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FX986_RS15625	COG3550	peptidyl-serine autophosphorylation
FX986_RS15630	COG1396	sequence-specific DNA binding
FX986_RS15670	COG1120	ATPase activity
FX986_RS15675	COG4139	cobalamin transport
FX986_RS15705	COG0583	DNA-binding transcription factor activity
FX986_RS15730	COG0745	RESPONSE REGULATOR receiver
FX986_RS15735	COG2205	protein histidine kinase activity
FX986_RS15740	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FX986_RS15745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FX986_RS15750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FX986_RS15765	COG4948	Mandelate Racemase Muconate Lactonizing
FX986_RS15770	COG3254	rhamnose metabolic process
FX986_RS15775	COG3618	amidohydrolase
FX986_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS15790	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS15810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS15825	COG4948	Mandelate Racemase Muconate Lactonizing
FX986_RS15830	COG3618	amidohydrolase
FX986_RS15835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FX986_RS15845	COG2186	Transcriptional regulator
FX986_RS15850	COG1609	Transcriptional regulator
FX986_RS15855	COG0366	Alpha amylase catalytic
FX986_RS15860	COG1653	transport
FX986_RS15865	COG0366	Alpha amylase catalytic
FX986_RS15870	COG0366	Alpha amylase catalytic
FX986_RS15875	COG3842	ATPase activity
FX986_RS15880	COG0366	Alpha amylase catalytic
FX986_RS15895	COG1653	transport
FX986_RS15915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS15920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS15935	COG0006	proline dipeptidase activity
FX986_RS15940	COG0583	DNA-binding transcription factor activity
FX986_RS15945	COG2084	Dehydrogenase
FX986_RS15960	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FX986_RS15965	COG4948	Mandelate Racemase Muconate Lactonizing
FX986_RS15970	COG1012	belongs to the aldehyde dehydrogenase family
FX986_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS16010	COG1396	sequence-specific DNA binding
FX986_RS16015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FX986_RS16025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS16075	COG0583	DNA-binding transcription factor activity
FX986_RS16080	COG3321	synthase
FX986_RS16080	COG0604	alcohol dehydrogenase
FX986_RS16085	COG4221	oxidoreductase activity
FX986_RS16095	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FX986_RS16120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FX986_RS16135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FX986_RS16140	COG2218	PFAM glutamate synthase alpha subunit domain protein
FX986_RS16145	COG0069	glutamate synthase activity
FX986_RS16155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FX986_RS16165	COG0004	ammonium transporteR
FX986_RS16180	COG0446	pyridine nucleotide-disulphide oxidoreductase
FX986_RS16180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FX986_RS16195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FX986_RS16215	COG0583	DNA-binding transcription factor activity
FX986_RS16235	COG0604	alcohol dehydrogenase
FX986_RS16260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS16275	COG4336	lyase activity
FX986_RS16290	COG0583	DNA-binding transcription factor activity
FX986_RS16300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS16310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS16315	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FX986_RS16325	COG1802	Transcriptional regulator
FX986_RS16330	COG1252	NADH dehydrogenase
FX986_RS16345	COG1902	pentaerythritol trinitrate reductase activity
FX986_RS16350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FX986_RS16355	COG0235	Class ii aldolase
FX986_RS16375	COG0583	DNA-binding transcription factor activity
FX986_RS16380	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FX986_RS16385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FX986_RS16390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FX986_RS16395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FX986_RS16405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS16405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FX986_RS16410	COG1794	racemase activity, acting on amino acids and derivatives
FX986_RS16415	COG2207	Transcriptional regulator
FX986_RS16420	COG2807	transmembrane transport
FX986_RS16455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FX986_RS16460	COG4172	Belongs to the ABC transporter superfamily
FX986_RS16470	COG5006	permease, DMT superfamily
FX986_RS16480	COG1757	Na H antiporter
FX986_RS16500	COG1971	Probably functions as a manganese efflux pump
FX986_RS16505	COG0625	glutathione transferase activity
FX986_RS16525	COG0583	DNA-binding transcription factor activity
FX986_RS16545	COG0583	DNA-binding transcription factor activity
FX986_RS16555	COG0431	NADPH-dependent FMN reductase
FX986_RS16565	COG0640	Transcriptional regulator
FX986_RS16580	COG3530	Putative quorum-sensing-regulated virulence factor
FX986_RS16655	COG0417	DNA replication proofreading
FX986_RS16660	COG4615	Cyclic peptide transporter
FX986_RS16690	COG4172	Belongs to the ABC transporter superfamily
FX986_RS16695	COG4239	(ABC) transporter, permease
FX986_RS16700	COG4174	ABC transporter (Permease)
FX986_RS16705	COG4166	transmembrane transport
FX986_RS16710	COG0741	lytic transglycosylase activity
FX986_RS16715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FX986_RS16720	COG2226	methyltransferase
FX986_RS16725	COG0328	RNA-DNA hybrid ribonuclease activity
FX986_RS16745	COG0616	signal peptide processing
FX986_RS16750	COG0640	Transcriptional regulator
FX986_RS16760	COG1757	Na H antiporter
FX986_RS16765	COG1115	amino acid carrier protein
FX986_RS16770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FX986_RS16775	COG1192	Involved in chromosome partitioning
FX986_RS16785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FX986_RS16800	COG2351	hydroxyisourate hydrolase activity
FX986_RS16820	COG0446	pyridine nucleotide-disulphide oxidoreductase
FX986_RS16820	COG1902	pentaerythritol trinitrate reductase activity
FX986_RS16855	COG0252	asparaginase activity
FX986_RS16870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FX986_RS16880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FX986_RS16890	COG1522	sequence-specific DNA binding
FX986_RS16895	COG0737	Belongs to the 5'-nucleotidase family
FX986_RS16900	COG2233	PERMEase
FX986_RS16915	COG0402	S-adenosylhomocysteine deaminase activity
FX986_RS16920	COG3608	succinylglutamate desuccinylase aspartoacylase
FX986_RS16920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FX986_RS16925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FX986_RS16930	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FX986_RS16935	COG1309	transcriptional regulator
FX986_RS16960	COG0765	amino acid transport
FX986_RS16965	COG0765	amino acid transport
FX986_RS16970	COG1126	abc transporter atp-binding protein
FX986_RS16975	COG0154	amidase activity
FX986_RS17000	COG0709	Synthesizes selenophosphate from selenide and ATP
FX986_RS17005	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FX986_RS17010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FX986_RS17015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FX986_RS17040	COG0521	Mo-molybdopterin cofactor biosynthetic process
FX986_RS17055	COG0437	4 iron, 4 sulfur cluster binding
FX986_RS17060	COG0243	molybdopterin cofactor binding
FX986_RS17060	COG3383	formate dehydrogenase (NAD+) activity
FX986_RS17090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FX986_RS17110	COG0045	succinate-CoA ligase (ADP-forming) activity
FX986_RS17110	COG1042	CoA-binding domain protein
FX986_RS17110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FX986_RS17130	COG0564	pseudouridine synthase activity
FX986_RS17140	COG0259	pyridoxamine-phosphate oxidase activity
FX986_RS17145	COG1687	branched-chain amino acid
FX986_RS17150	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FX986_RS17170	COG1295	ribonuclease BN
FX986_RS17175	COG3842	ATPase activity
FX986_RS17180	COG1176	ABC-type spermidine putrescine transport system, permease component I
FX986_RS17185	COG1177	transmembrane transport
FX986_RS17195	COG2840	Smr protein MutS2
FX986_RS17205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS17210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FX986_RS17220	COG1301	dicarboxylic acid transport
FX986_RS17225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FX986_RS17230	COG0022	dehydrogenase e1 component
FX986_RS17245	COG1027	Aspartate ammonia-lyase
FX986_RS17250	COG0583	DNA-binding transcription factor activity
FX986_RS17255	COG1056	cytidyltransferase-related domain
FX986_RS17255	COG1051	belongs to the nudix hydrolase family
FX986_RS17275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FX986_RS17285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FX986_RS17290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FX986_RS17295	COG0632	four-way junction helicase activity
FX986_RS17300	COG2255	four-way junction helicase activity
FX986_RS17305	COG0824	Thioesterase
FX986_RS17325	COG0823	Involved in the tonB-independent uptake of proteins
FX986_RS17330	COG2885	chlorophyll binding
FX986_RS17340	COG1028	Short-chain dehydrogenase reductase Sdr
FX986_RS17360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FX986_RS17370	COG0604	alcohol dehydrogenase
FX986_RS17390	COG2911	Protein conserved in bacteria
FX986_RS17395	COG3012	SEC-C Motif Domain Protein
FX986_RS17405	COG2814	Major facilitator Superfamily
FX986_RS17415	COG0429	hydrolase of the alpha beta-hydrolase fold
FX986_RS17420	COG0006	proline dipeptidase activity
FX986_RS17425	COG0583	DNA-binding transcription factor activity
FX986_RS17430	COG4608	Belongs to the ABC transporter superfamily
FX986_RS17435	COG0444	Belongs to the ABC transporter superfamily
FX986_RS17440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FX986_RS17445	COG0601	transmembrane transport
FX986_RS17450	COG0747	negative chemotaxis
FX986_RS17455	COG0288	reversible hydration of carbon dioxide
FX986_RS17475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FX986_RS17490	COG2166	iron-sulfur cluster assembly
FX986_RS17500	COG5642	Protein of unknown function (DUF2384)
FX986_RS17505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FX986_RS17510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FX986_RS17515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FX986_RS17520	COG1121	(ABC) transporter
FX986_RS17530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FX986_RS17535	COG0735	belongs to the Fur family
FX986_RS17555	COG0189	ligase activity
FX986_RS17555	COG4067	protein conserved in archaea
FX986_RS17565	COG1716	ATPase activity
FX986_RS17565	COG5001	Diguanylate cyclase
FX986_RS17570	COG1917	Cupin 2, conserved barrel domain protein
FX986_RS17575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FX986_RS17580	COG0456	acetyltransferase
FX986_RS17590	COG0316	Belongs to the HesB IscA family
FX986_RS17590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FX986_RS17600	COG0534	Mate efflux family protein
FX986_RS17615	COG5001	Diguanylate cyclase
FX986_RS17615	COG3300	MHYT domain