locus-tag	class	description
EKO29_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EKO29_RS00020	COG0187	DNA topoisomerase II activity
EKO29_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
EKO29_RS00030	COG0751	glycine-tRNA ligase activity
EKO29_RS00035	COG0596	Alpha beta hydrolase
EKO29_RS00040	COG3706	GGDEF domain
EKO29_RS00045	COG0425	Belongs to the sulfur carrier protein TusA family
EKO29_RS00055	COG0006	proline dipeptidase activity
EKO29_RS00060	COG1739	Uncharacterized protein family UPF0029
EKO29_RS00065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EKO29_RS00070	COG0569	domain protein
EKO29_RS00075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EKO29_RS00075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EKO29_RS00095	COG0758	DNA mediated transformation
EKO29_RS00100	COG2922	Belongs to the Smg family
EKO29_RS00105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EKO29_RS00115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EKO29_RS00125	COG4946	Tricorn protease homolog
EKO29_RS00125	COG0823	Involved in the tonB-independent uptake of proteins
EKO29_RS00125	COG1506	peptidase
EKO29_RS00140	COG3047	cAMP biosynthetic process
EKO29_RS00155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EKO29_RS00190	COG0745	RESPONSE REGULATOR receiver
EKO29_RS00195	COG0513	Belongs to the DEAD box helicase family
EKO29_RS00200	COG1671	Belongs to the UPF0178 family
EKO29_RS00220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EKO29_RS00245	COG1609	Transcriptional regulator
EKO29_RS00290	COG2211	Major facilitator Superfamily
EKO29_RS00295	COG3459	Glycosyltransferase 36 associated
EKO29_RS00300	COG3265	gluconokinase activity
EKO29_RS00320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EKO29_RS00325	COG0583	DNA-binding transcription factor activity
EKO29_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EKO29_RS00345	COG2356	endonuclease I
EKO29_RS00415	COG2081	HI0933 family
EKO29_RS00420	COG3038	cytochrome b561
EKO29_RS00430	COG1528	Iron-storage protein
EKO29_RS00435	COG0678	peroxiredoxin activity
EKO29_RS00440	COG0840	transmembrane signaling receptor activity
EKO29_RS00450	COG1252	NADH dehydrogenase
EKO29_RS00485	COG0745	RESPONSE REGULATOR receiver
EKO29_RS00490	COG0742	ribosomal rna small subunit methyltransferase
EKO29_RS00515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKO29_RS00520	COG1575	Belongs to the MenA family. Type 1 subfamily
EKO29_RS00525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EKO29_RS00525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EKO29_RS00530	COG0612	Peptidase, M16
EKO29_RS00550	COG1879	ABC-type sugar transport system periplasmic component
EKO29_RS00575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EKO29_RS00585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EKO29_RS00590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EKO29_RS00620	COG0789	Transcriptional regulator
EKO29_RS00670	COG0583	DNA-binding transcription factor activity
EKO29_RS00675	COG2259	Doxx family
EKO29_RS00680	COG1741	Belongs to the pirin family
EKO29_RS00685	COG0583	DNA-binding transcription factor activity
EKO29_RS00700	COG1253	flavin adenine dinucleotide binding
EKO29_RS00715	COG1979	alcohol dehydrogenase
EKO29_RS00725	COG2165	general secretion pathway protein
EKO29_RS00745	COG0840	transmembrane signaling receptor activity
EKO29_RS00755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EKO29_RS00810	COG1131	(ABC) transporter
EKO29_RS00825	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKO29_RS00860	COG3634	alkyl hydroperoxide reductase activity
EKO29_RS00865	COG0583	DNA-binding transcription factor activity
EKO29_RS00870	COG0840	transmembrane signaling receptor activity
EKO29_RS00875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EKO29_RS00880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EKO29_RS00885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EKO29_RS00905	COG3346	SURF1 family
EKO29_RS00920	COG0109	protoheme IX farnesyltransferase activity
EKO29_RS00930	COG0726	polysaccharide deacetylase
EKO29_RS00930	COG1649	PFAM Uncharacterised BCR, COG1649
EKO29_RS00935	COG0534	Mate efflux family protein
EKO29_RS00945	COG0316	Belongs to the HesB IscA family
EKO29_RS00945	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EKO29_RS00955	COG1040	competence protein
EKO29_RS00960	COG0596	Alpha beta hydrolase
EKO29_RS00975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EKO29_RS00980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EKO29_RS01000	COG1561	YicC-like family, N-terminal region
EKO29_RS01005	COG3132	Protein of unknown function, DUF480
EKO29_RS01025	COG0513	Belongs to the DEAD box helicase family
EKO29_RS01030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO29_RS01035	COG1278	Cold shock
EKO29_RS01050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EKO29_RS01060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EKO29_RS01070	COG0438	transferase activity, transferring glycosyl groups
EKO29_RS01075	COG0438	transferase activity, transferring glycosyl groups
EKO29_RS01095	COG4772	TonB-dependent receptor
EKO29_RS01100	COG0668	transmembrane transport
EKO29_RS01105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKO29_RS01135	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EKO29_RS01140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EKO29_RS01170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EKO29_RS01175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EKO29_RS01185	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EKO29_RS01200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKO29_RS01210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EKO29_RS01215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EKO29_RS01220	COG0137	argininosuccinate synthase activity
EKO29_RS01225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EKO29_RS01225	COG0165	Argininosuccinate lyase
EKO29_RS01230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EKO29_RS01230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EKO29_RS01255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EKO29_RS01255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EKO29_RS01285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EKO29_RS01305	COG0250	Participates in transcription elongation, termination and antitermination
EKO29_RS01310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EKO29_RS01315	COG0081	regulation of translation
EKO29_RS01320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EKO29_RS01335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EKO29_RS01340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EKO29_RS01345	COG0049	tRNA binding
EKO29_RS01350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EKO29_RS01355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EKO29_RS01360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EKO29_RS01365	COG0051	transcription antitermination factor activity, RNA binding
EKO29_RS01370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EKO29_RS01375	COG0088	Forms part of the polypeptide exit tunnel
EKO29_RS01380	COG0089	rRNA binding
EKO29_RS01385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EKO29_RS01390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EKO29_RS01395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EKO29_RS01400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EKO29_RS01405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EKO29_RS01410	COG0255	Belongs to the universal ribosomal protein uL29 family
EKO29_RS01415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EKO29_RS01420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EKO29_RS01425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EKO29_RS01430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EKO29_RS01435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EKO29_RS01440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EKO29_RS01445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EKO29_RS01450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EKO29_RS01455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EKO29_RS01460	COG1841	ribosomal large subunit assembly
EKO29_RS01465	COG0200	Binds to the 23S rRNA
EKO29_RS01470	COG0201	protein transport
EKO29_RS01475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EKO29_RS01480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EKO29_RS01485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EKO29_RS01490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EKO29_RS01495	COG0202	RNA polymerase activity
EKO29_RS01500	COG0203	ribosomal protein L17
EKO29_RS01505	COG3954	Phosphoribulokinase
EKO29_RS01510	COG1765	OsmC-like protein
EKO29_RS01525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKO29_RS01535	COG2204	response regulator
EKO29_RS01540	COG3409	Peptidoglycan-binding domain 1 protein
EKO29_RS01540	COG3267	Type II secretory pathway component ExeA
EKO29_RS01550	COG0489	protein tyrosine kinase activity
EKO29_RS01565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EKO29_RS01575	COG0438	transferase activity, transferring glycosyl groups
EKO29_RS01585	COG1215	transferase activity, transferring glycosyl groups
EKO29_RS01595	COG0726	polysaccharide deacetylase
EKO29_RS01610	COG1216	Glycosyl transferase, family 2
EKO29_RS01675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EKO29_RS01700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EKO29_RS01715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EKO29_RS01720	COG2861	carbohydrate metabolic process
EKO29_RS01725	COG4942	peptidase
EKO29_RS01730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EKO29_RS01735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKO29_RS01740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EKO29_RS01745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EKO29_RS01750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EKO29_RS01755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EKO29_RS01765	COG2267	carboxylic ester hydrolase activity
EKO29_RS01770	COG2205	protein histidine kinase activity
EKO29_RS01780	COG0745	RESPONSE REGULATOR receiver
EKO29_RS01790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EKO29_RS01800	COG0584	glycerophosphoryl diester phosphodiesterase
EKO29_RS01805	COG0688	phosphatidylethanolamine metabolic process
EKO29_RS01810	COG1162	GTPase activity
EKO29_RS01815	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EKO29_RS01845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EKO29_RS01845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EKO29_RS01850	COG0802	atpase or kinase
EKO29_RS01855	COG0860	N-Acetylmuramoyl-L-alanine amidase
EKO29_RS01865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EKO29_RS01870	COG1923	regulation of RNA biosynthetic process
EKO29_RS01875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EKO29_RS01880	COG0330	HflC and HflK could
EKO29_RS01885	COG0330	HflC and HflK could
EKO29_RS01890	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EKO29_RS01895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EKO29_RS01900	COG0281	malic enzyme
EKO29_RS01910	COG3604	Transcriptional regulator
EKO29_RS01915	COG0348	domain, Protein
EKO29_RS01920	COG0346	lactoylglutathione lyase activity
EKO29_RS01930	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EKO29_RS01935	COG0626	cystathionine gamma-synthase activity
EKO29_RS01940	COG0460	homoserine dehydrogenase
EKO29_RS01940	COG0527	aspartate kinase activity
EKO29_RS01955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EKO29_RS01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EKO29_RS01980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EKO29_RS01985	COG2315	Protein conserved in bacteria
EKO29_RS02035	COG1215	transferase activity, transferring glycosyl groups
EKO29_RS02040	COG3769	mannosylglycerate metabolic process
EKO29_RS02055	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS02090	COG0583	DNA-binding transcription factor activity
EKO29_RS02140	COG1595	DNA-templated transcription, initiation
EKO29_RS02145	COG3806	Anti-sigma factor
EKO29_RS02165	COG4221	oxidoreductase activity
EKO29_RS02180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EKO29_RS02205	COG1429	ligase activity, forming nitrogen-metal bonds
EKO29_RS02225	COG4206	TonB-dependent receptor
EKO29_RS02230	COG1785	Belongs to the alkaline phosphatase family
EKO29_RS02235	COG1785	Belongs to the alkaline phosphatase family
EKO29_RS02245	COG1648	precorrin-2 dehydrogenase activity
EKO29_RS02245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EKO29_RS02250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EKO29_RS02255	COG2264	protein methyltransferase activity
EKO29_RS02260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EKO29_RS02265	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EKO29_RS02270	COG0138	bifunctional purine biosynthesis protein purh
EKO29_RS02280	COG0151	Belongs to the GarS family
EKO29_RS02325	COG2204	response regulator
EKO29_RS02330	COG3852	Histidine kinase
EKO29_RS02340	COG0174	glutamine synthetase
EKO29_RS02345	COG1217	gtp-binding protein TYPA
EKO29_RS02355	COG1295	ribonuclease BN
EKO29_RS02370	COG1490	D-aminoacyl-tRNA deacylase activity
EKO29_RS02380	COG0456	acetyltransferase
EKO29_RS02390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EKO29_RS02400	COG0330	HflC and HflK could
EKO29_RS02405	COG0330	HflC and HflK could
EKO29_RS02415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EKO29_RS02420	COG2986	histidine ammonia-lyase
EKO29_RS02425	COG2188	Transcriptional regulator
EKO29_RS02435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EKO29_RS02450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EKO29_RS02455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EKO29_RS02465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EKO29_RS02470	COG0254	rRNA binding
EKO29_RS02490	COG0305	Participates in initiation and elongation during chromosome replication
EKO29_RS02495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EKO29_RS02540	COG0840	transmembrane signaling receptor activity
EKO29_RS02550	COG1335	isochorismatase
EKO29_RS02565	COG3085	chromosome segregation
EKO29_RS02580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EKO29_RS02585	COG2897	thiosulfate sulfurtransferase activity
EKO29_RS02595	COG1842	Phage shock protein A
EKO29_RS02630	COG1404	Belongs to the peptidase S8 family
EKO29_RS02635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EKO29_RS02640	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EKO29_RS02645	COG3031	protein transport across the cell outer membrane
EKO29_RS02655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EKO29_RS02660	COG1459	type II secretion system
EKO29_RS02665	COG2165	general secretion pathway protein
EKO29_RS02675	COG2165	general secretion pathway protein
EKO29_RS02680	COG4795	General secretion pathway protein
EKO29_RS02685	COG3156	type II secretion system protein K
EKO29_RS02695	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EKO29_RS02705	COG1011	Hydrolase
EKO29_RS02710	COG0494	nUDIX hydrolase
EKO29_RS02725	COG3089	Belongs to the UPF0270 family
EKO29_RS02730	COG0429	hydrolase of the alpha beta-hydrolase fold
EKO29_RS02745	COG0488	(ABC) transporter
EKO29_RS02750	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EKO29_RS02775	COG0745	RESPONSE REGULATOR receiver
EKO29_RS02780	COG2205	protein histidine kinase activity
EKO29_RS02795	COG2900	Belongs to the SlyX family
EKO29_RS02805	COG0545	Peptidyl-prolyl cis-trans isomerase
EKO29_RS02815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EKO29_RS02830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKO29_RS02845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EKO29_RS02890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKO29_RS02895	COG0175	sulfate reduction
EKO29_RS02905	COG5001	Diguanylate cyclase
EKO29_RS02905	COG3300	MHYT domain
EKO29_RS02920	COG5002	protein histidine kinase activity
EKO29_RS02920	COG3850	Histidine kinase
EKO29_RS02925	COG0745	RESPONSE REGULATOR receiver
EKO29_RS02930	COG2194	sulfuric ester hydrolase activity
EKO29_RS02935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EKO29_RS02945	COG1024	Enoyl-CoA hydratase
EKO29_RS02945	COG1250	3-hydroxyacyl-CoA dehydrogenase
EKO29_RS02950	COG0183	Belongs to the thiolase family
EKO29_RS02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EKO29_RS03010	COG1505	serine-type exopeptidase activity
EKO29_RS03035	COG1320	monovalent cation:proton antiporter activity
EKO29_RS03055	COG0651	ATP synthesis coupled electron transport
EKO29_RS03065	COG1227	inorganic diphosphatase activity
EKO29_RS03070	COG0823	Involved in the tonB-independent uptake of proteins
EKO29_RS03070	COG1506	peptidase
EKO29_RS03070	COG4946	Tricorn protease homolog
EKO29_RS03075	COG1294	oxidase, subunit
EKO29_RS03080	COG1271	oxidase subunit
EKO29_RS03090	COG0840	transmembrane signaling receptor activity
EKO29_RS03095	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EKO29_RS03115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EKO29_RS03120	COG2814	Major facilitator Superfamily
EKO29_RS03125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EKO29_RS03135	COG0439	Biotin carboxylase
EKO29_RS03140	COG0511	ligase activity, forming carbon-carbon bonds
EKO29_RS03145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EKO29_RS03170	COG4232	protein-disulfide reductase activity
EKO29_RS03175	COG1324	tolerance protein
EKO29_RS03180	COG3030	protein affecting phage T7 exclusion by the F plasmid
EKO29_RS03185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EKO29_RS03200	COG2207	Transcriptional regulator
EKO29_RS03230	COG0625	glutathione transferase activity
EKO29_RS03270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKO29_RS03285	COG1509	lysine 2,3-aminomutase activity
EKO29_RS03290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EKO29_RS03310	COG1131	(ABC) transporter
EKO29_RS03315	COG0842	Transport permease protein
EKO29_RS03320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EKO29_RS03325	COG0076	glutamate decarboxylase activity
EKO29_RS03330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EKO29_RS03335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EKO29_RS03340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EKO29_RS03345	COG0617	tRNA 3'-terminal CCA addition
EKO29_RS03375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EKO29_RS03380	COG1643	Atp-dependent helicase
EKO29_RS03395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EKO29_RS03400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EKO29_RS03405	COG2823	Periplasmic or secreted lipoprotein
EKO29_RS03410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EKO29_RS03420	COG3107	peptidoglycan biosynthetic process
EKO29_RS03425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EKO29_RS03445	COG1309	transcriptional regulator
EKO29_RS03465	COG3046	protein related to deoxyribodipyrimidine photolyase
EKO29_RS03475	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EKO29_RS03475	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EKO29_RS03475	COG0506	proline dehydrogenase activity
EKO29_RS03485	COG2207	Transcriptional regulator
EKO29_RS03485	COG1609	Transcriptional regulator
EKO29_RS03515	COG2815	serine threonine protein kinase
EKO29_RS03515	COG0515	serine threonine protein kinase
EKO29_RS03535	COG0572	uridine kinase
EKO29_RS03545	COG0564	pseudouridine synthase activity
EKO29_RS03580	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
EKO29_RS03600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EKO29_RS03610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EKO29_RS03615	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EKO29_RS03625	COG1492	cobalamin metabolic process
EKO29_RS03635	COG4206	TonB-dependent receptor
EKO29_RS03650	COG0588	phosphoglycerate mutase activity
EKO29_RS03660	COG1797	cobyrinic acid a,c-diamide synthase activity
EKO29_RS03665	COG1429	ligase activity, forming nitrogen-metal bonds
EKO29_RS03680	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EKO29_RS03700	COG5002	protein histidine kinase activity
EKO29_RS03700	COG3850	Histidine kinase
EKO29_RS03725	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS03740	COG1438	arginine binding
EKO29_RS03750	COG0142	geranyltranstransferase activity
EKO29_RS03755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EKO29_RS03760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EKO29_RS03765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EKO29_RS03775	COG0840	transmembrane signaling receptor activity
EKO29_RS03785	COG2967	ApaG domain
EKO29_RS03790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EKO29_RS03795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EKO29_RS03800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EKO29_RS03805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EKO29_RS03820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EKO29_RS03845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EKO29_RS03850	COG4206	TonB-dependent receptor
EKO29_RS03895	COG0300	oxidoreductase activity
EKO29_RS03915	COG1858	cytochrome C peroxidase
EKO29_RS03930	COG1610	YqeY-like protein
EKO29_RS03935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EKO29_RS03940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EKO29_RS03945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EKO29_RS03950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EKO29_RS03955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EKO29_RS03955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EKO29_RS03960	COG1968	undecaprenyl-diphosphatase activity
EKO29_RS03965	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS03970	COG3118	belongs to the thioredoxin family
EKO29_RS03975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EKO29_RS03985	COG3530	Putative quorum-sensing-regulated virulence factor
EKO29_RS03990	COG3130	regulation of translation
EKO29_RS03995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EKO29_RS04015	COG0521	Mo-molybdopterin cofactor biosynthetic process
EKO29_RS04020	COG0746	molybdenum cofactor guanylyltransferase activity
EKO29_RS04030	COG0303	'Molybdopterin
EKO29_RS04035	COG0596	Alpha beta hydrolase
EKO29_RS04040	COG0513	Belongs to the DEAD box helicase family
EKO29_RS04045	COG3141	response to X-ray
EKO29_RS04055	COG0745	RESPONSE REGULATOR receiver
EKO29_RS04065	COG3706	GGDEF domain
EKO29_RS04070	COG0460	homoserine dehydrogenase
EKO29_RS04070	COG0527	aspartate kinase activity
EKO29_RS04075	COG0083	homoserine kinase activity
EKO29_RS04080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EKO29_RS04085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EKO29_RS04120	COG0583	DNA-binding transcription factor activity
EKO29_RS04140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EKO29_RS04160	COG0281	malic enzyme
EKO29_RS04165	COG0105	UTP biosynthetic process
EKO29_RS04170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EKO29_RS04175	COG1388	LysM domain
EKO29_RS04175	COG3584	3D domain protein
EKO29_RS04185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EKO29_RS04190	COG0124	histidyl-tRNA synthetase
EKO29_RS04195	COG2976	Protein conserved in bacteria
EKO29_RS04200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKO29_RS04205	COG1160	GTP binding
EKO29_RS04215	COG1570	exodeoxyribonuclease VII activity
EKO29_RS04220	COG0517	IMP dehydrogenase activity
EKO29_RS04220	COG0516	GMP reductase activity
EKO29_RS04225	COG0519	Catalyzes the synthesis of GMP from XMP
EKO29_RS04225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EKO29_RS04245	COG3279	Response regulator of the LytR AlgR family
EKO29_RS04255	COG0514	ATP-dependent DNA helicase (RecQ)
EKO29_RS04270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EKO29_RS04280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EKO29_RS04285	COG1595	DNA-templated transcription, initiation
EKO29_RS04305	COG0481	GTPase activity
EKO29_RS04310	COG0681	Belongs to the peptidase S26 family
EKO29_RS04315	COG0571	ribonuclease III activity
EKO29_RS04325	COG1381	Involved in DNA repair and RecF pathway recombination
EKO29_RS04330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EKO29_RS04335	COG0736	holo-[acyl-carrier-protein] synthase activity
EKO29_RS04345	COG3437	response regulator, receiver
EKO29_RS04345	COG3850	Histidine kinase
EKO29_RS04345	COG4999	Histidine kinase
EKO29_RS04345	COG2205	protein histidine kinase activity
EKO29_RS04355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EKO29_RS04365	COG3956	TIGRFAM MazG family protein
EKO29_RS04370	COG1024	Enoyl-CoA hydratase
EKO29_RS04375	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EKO29_RS04380	COG0217	transcriptional regulatory protein
EKO29_RS04400	COG2066	Belongs to the glutaminase family
EKO29_RS04410	COG0583	DNA-binding transcription factor activity
EKO29_RS04415	COG0243	molybdopterin cofactor binding
EKO29_RS04425	COG2146	nitrite reductase [NAD(P)H] activity
EKO29_RS04425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EKO29_RS04435	COG1116	anion transmembrane transporter activity
EKO29_RS04440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EKO29_RS04445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EKO29_RS04445	COG1116	anion transmembrane transporter activity
EKO29_RS04450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EKO29_RS04450	COG1116	anion transmembrane transporter activity
EKO29_RS04455	COG2201	protein-glutamate methylesterase activity
EKO29_RS04470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EKO29_RS04480	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS04530	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS04540	COG2801	Transposase and inactivated derivatives
EKO29_RS04560	COG1280	lysine exporter protein (LysE YggA)
EKO29_RS04590	COG2205	protein histidine kinase activity
EKO29_RS04595	COG0745	RESPONSE REGULATOR receiver
EKO29_RS04640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKO29_RS04650	COG1166	arginine decarboxylase activity
EKO29_RS04670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EKO29_RS04680	COG3171	Protein conserved in bacteria
EKO29_RS04690	COG0840	transmembrane signaling receptor activity
EKO29_RS04695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EKO29_RS04730	COG4555	ABC transporter
EKO29_RS04750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKO29_RS04755	COG0215	cysteine-tRNA ligase activity
EKO29_RS04760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EKO29_RS04785	COG0544	peptidyl-prolyl cis-trans isomerase activity
EKO29_RS04790	COG0740	serine-type endopeptidase activity
EKO29_RS04795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EKO29_RS04800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EKO29_RS04830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EKO29_RS04835	COG4172	Belongs to the ABC transporter superfamily
EKO29_RS04845	COG4171	peptide transport system, permease
EKO29_RS04850	COG4168	peptide transport system, permease
EKO29_RS04855	COG0747	negative chemotaxis
EKO29_RS04860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EKO29_RS04865	COG1842	Phage shock protein A
EKO29_RS04885	COG3106	COG3106 Predicted ATPase
EKO29_RS04890	COG3768	UPF0283 membrane protein
EKO29_RS04900	COG2154	pterin-4-alpha-carbinolamine dehydratase
EKO29_RS04910	COG0625	glutathione transferase activity
EKO29_RS04930	COG0471	metal ion transport
EKO29_RS04930	COG3273	potassium ion transport
EKO29_RS04965	COG0811	peptide transport
EKO29_RS04970	COG0811	peptide transport
EKO29_RS04975	COG0848	biopolymer transport protein
EKO29_RS04990	COG0745	RESPONSE REGULATOR receiver
EKO29_RS04995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EKO29_RS05000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EKO29_RS05005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EKO29_RS05015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EKO29_RS05045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EKO29_RS05065	COG3483	tryptophan 2,3-dioxygenase activity
EKO29_RS05070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKO29_RS05075	COG3844	kynureninase activity
EKO29_RS05090	COG0662	Cupin 2, conserved barrel domain protein
EKO29_RS05120	COG0071	Belongs to the small heat shock protein (HSP20) family
EKO29_RS05125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EKO29_RS05130	COG2201	protein-glutamate methylesterase activity
EKO29_RS05135	COG3706	GGDEF domain
EKO29_RS05150	COG0577	efflux transmembrane transporter activity
EKO29_RS05160	COG1136	(ABC) transporter
EKO29_RS05165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS05170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EKO29_RS05175	COG4535	Mg2 and Co2 transporter CorC
EKO29_RS05180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EKO29_RS05185	COG1702	phosphate starvation-inducible protein PhoH
EKO29_RS05190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EKO29_RS05210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKO29_RS05245	COG0012	GTP binding
EKO29_RS05250	COG0193	aminoacyl-tRNA hydrolase activity
EKO29_RS05255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EKO29_RS05275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EKO29_RS05280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EKO29_RS05285	COG2890	protein-(glutamine-N5) methyltransferase activity
EKO29_RS05295	COG2912	Transglutaminase-like superfamily
EKO29_RS05305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EKO29_RS05310	COG1301	dicarboxylic acid transport
EKO29_RS05340	COG0583	DNA-binding transcription factor activity
EKO29_RS05345	COG1760	l-serine dehydratase
EKO29_RS05350	COG0494	nUDIX hydrolase
EKO29_RS05355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EKO29_RS05365	COG0823	Involved in the tonB-independent uptake of proteins
EKO29_RS05365	COG1506	peptidase
EKO29_RS05385	COG0733	neurotransmitter:sodium symporter activity
EKO29_RS05395	COG2205	protein histidine kinase activity
EKO29_RS05395	COG0784	Response regulator, receiver
EKO29_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS05425	COG0657	acetylesterase activity
EKO29_RS05450	COG2186	Transcriptional regulator
EKO29_RS05470	COG2271	Major facilitator Superfamily
EKO29_RS05475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKO29_RS05480	COG0800	Aldolase
EKO29_RS05490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EKO29_RS05495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EKO29_RS05515	COG0604	alcohol dehydrogenase
EKO29_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS05515	COG3321	synthase
EKO29_RS05520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EKO29_RS05555	COG0753	catalase activity
EKO29_RS05560	COG0735	belongs to the Fur family
EKO29_RS05570	COG0823	Involved in the tonB-independent uptake of proteins
EKO29_RS05570	COG1506	peptidase
EKO29_RS05570	COG4946	Tricorn protease homolog
EKO29_RS05580	COG0716	FMN binding
EKO29_RS05595	COG0596	Alpha beta hydrolase
EKO29_RS05605	COG0033	Phosphoglucomutase
EKO29_RS05610	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EKO29_RS05630	COG2988	succinylglutamate desuccinylase activity
EKO29_RS05640	COG0022	dehydrogenase e1 component
EKO29_RS05645	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKO29_RS05665	COG4251	negative regulation of phosphorylation
EKO29_RS05670	COG2197	response regulator
EKO29_RS05690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EKO29_RS05700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKO29_RS05705	COG2226	methyltransferase
EKO29_RS05715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EKO29_RS05720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EKO29_RS05725	COG0632	four-way junction helicase activity
EKO29_RS05730	COG2255	four-way junction helicase activity
EKO29_RS05735	COG0824	Thioesterase
EKO29_RS05740	COG0811	peptide transport
EKO29_RS05755	COG0823	Involved in the tonB-independent uptake of proteins
EKO29_RS05760	COG2885	chlorophyll binding
EKO29_RS05765	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EKO29_RS05790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EKO29_RS05830	COG0840	transmembrane signaling receptor activity
EKO29_RS05840	COG3706	GGDEF domain
EKO29_RS05845	COG0778	Nitroreductase
EKO29_RS05855	COG1404	Belongs to the peptidase S8 family
EKO29_RS05865	COG0745	RESPONSE REGULATOR receiver
EKO29_RS05865	COG3292	Two component regulator propeller
EKO29_RS05865	COG2205	protein histidine kinase activity
EKO29_RS05870	COG1451	nucleotide metabolic process
EKO29_RS05875	COG0166	Belongs to the GPI family
EKO29_RS05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS05900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKO29_RS05940	COG3220	belongs to the UPF0276 family
EKO29_RS05950	COG3118	belongs to the thioredoxin family
EKO29_RS05970	COG0457	Tetratricopeptide repeat
EKO29_RS05975	COG4771	TonB-dependent receptor
EKO29_RS05980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EKO29_RS05985	COG1846	Transcriptional regulator
EKO29_RS05990	COG1914	H( )-stimulated, divalent metal cation uptake system
EKO29_RS06000	COG1846	Transcriptional regulator
EKO29_RS06005	COG1566	PFAM secretion protein HlyD family protein
EKO29_RS06015	COG1764	response to oxidative stress
EKO29_RS06020	COG1846	Transcriptional regulator
EKO29_RS06040	COG1309	transcriptional regulator
EKO29_RS06045	COG1472	Belongs to the glycosyl hydrolase 3 family
EKO29_RS06050	COG0471	metal ion transport
EKO29_RS06060	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKO29_RS06065	COG1404	Belongs to the peptidase S8 family
EKO29_RS06070	COG0745	RESPONSE REGULATOR receiver
EKO29_RS06080	COG0640	Transcriptional regulator
EKO29_RS06105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EKO29_RS06140	COG3292	Two component regulator propeller
EKO29_RS06140	COG0745	RESPONSE REGULATOR receiver
EKO29_RS06140	COG2205	protein histidine kinase activity
EKO29_RS06170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EKO29_RS06175	COG0450	alkyl hydroperoxide reductase
EKO29_RS06185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EKO29_RS06205	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EKO29_RS06210	COG1196	nuclear chromosome segregation
EKO29_RS06220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EKO29_RS06250	COG0745	RESPONSE REGULATOR receiver
EKO29_RS06255	COG5002	protein histidine kinase activity
EKO29_RS06260	COG0501	Belongs to the peptidase M48B family
EKO29_RS06275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EKO29_RS06280	COG0166	Belongs to the GPI family
EKO29_RS06290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EKO29_RS06295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EKO29_RS06295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EKO29_RS06300	COG0246	Mannitol dehydrogenase
EKO29_RS06315	COG0545	Peptidyl-prolyl cis-trans isomerase
EKO29_RS06325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EKO29_RS06330	COG0505	Belongs to the CarA family
EKO29_RS06335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EKO29_RS06340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EKO29_RS06350	COG1534	Rna-binding protein
EKO29_RS06355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EKO29_RS06365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EKO29_RS06370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EKO29_RS06375	COG0149	triose-phosphate isomerase activity
EKO29_RS06380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EKO29_RS06400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EKO29_RS06405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EKO29_RS06425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EKO29_RS06430	COG4136	ATPase activity
EKO29_RS06435	COG4135	transport system, permease component
EKO29_RS06440	COG4134	Bacterial extracellular solute-binding protein
EKO29_RS06475	COG1595	DNA-templated transcription, initiation
EKO29_RS06480	COG3784	Protein of unknown function (DUF1318)
EKO29_RS06495	COG0400	carboxylic ester hydrolase activity
EKO29_RS06555	COG0745	RESPONSE REGULATOR receiver
EKO29_RS06610	COG1132	(ABC) transporter
EKO29_RS06645	COG0534	Mate efflux family protein
EKO29_RS06650	COG0307	riboflavin synthase, alpha
EKO29_RS06660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EKO29_RS06665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EKO29_RS06675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EKO29_RS06680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EKO29_RS06685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EKO29_RS06690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EKO29_RS06695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EKO29_RS06700	COG0347	Belongs to the P(II) protein family
EKO29_RS06705	COG0004	ammonium transporteR
EKO29_RS06710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EKO29_RS06715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EKO29_RS06715	COG0072	phenylalanine-tRNA ligase activity
EKO29_RS06720	COG0776	regulation of translation
EKO29_RS06750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EKO29_RS06765	COG5265	(ABC) transporter
EKO29_RS06790	COG0037	tRNA processing
EKO29_RS06800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKO29_RS06815	COG2217	Heavy metal translocating P-type atpase
EKO29_RS06825	COG2010	Cytochrome c
EKO29_RS06840	COG3278	Belongs to the heme-copper respiratory oxidase family
EKO29_RS06845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKO29_RS06855	COG1280	lysine exporter protein (LysE YggA)
EKO29_RS06860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKO29_RS06925	COG0534	Mate efflux family protein
EKO29_RS06930	COG0556	nucleotide-excision repair
EKO29_RS06940	COG2084	Dehydrogenase
EKO29_RS06955	COG2925	Exonuclease
EKO29_RS06990	COG0612	Peptidase, M16
EKO29_RS07005	COG0210	DNA helicase
EKO29_RS07020	COG3437	response regulator, receiver
EKO29_RS07020	COG0784	Response regulator, receiver
EKO29_RS07025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKO29_RS07025	COG4191	Histidine kinase
EKO29_RS07030	COG0741	lytic transglycosylase activity
EKO29_RS07035	COG3021	interspecies interaction between organisms
EKO29_RS07040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EKO29_RS07060	COG2703	oxygen carrier activity
EKO29_RS07090	COG0714	Associated with various cellular activities
EKO29_RS07095	COG1845	cytochrome c oxidase, subunit III
EKO29_RS07110	COG2010	Cytochrome c
EKO29_RS07155	COG0596	Alpha beta hydrolase
EKO29_RS07160	COG0714	Associated with various cellular activities
EKO29_RS07195	COG4977	sequence-specific DNA binding
EKO29_RS07195	COG1917	Cupin 2, conserved barrel domain protein
EKO29_RS07200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKO29_RS07275	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EKO29_RS07280	COG1074	ATP-dependent DNA helicase activity
EKO29_RS07285	COG1074	ATP-dependent DNA helicase activity
EKO29_RS07290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO29_RS07330	COG1999	signal sequence binding
EKO29_RS07345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EKO29_RS07420	COG0789	Transcriptional regulator
EKO29_RS07425	COG0454	-acetyltransferase
EKO29_RS07450	COG4109	DRTGG domain
EKO29_RS07455	COG1643	Atp-dependent helicase
EKO29_RS07465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EKO29_RS07470	COG1254	Belongs to the acylphosphatase family
EKO29_RS07490	COG0314	molybdopterin synthase activity
EKO29_RS07495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EKO29_RS07500	COG0315	cyclic pyranopterin monophosphate synthase activity
EKO29_RS07530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EKO29_RS07530	COG0116	Belongs to the methyltransferase superfamily
EKO29_RS07540	COG0488	(ABC) transporter
EKO29_RS07550	COG0440	acetolactate synthase activity
EKO29_RS07580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EKO29_RS07595	COG0134	indole-3-glycerol-phosphate synthase activity
EKO29_RS07595	COG0135	phosphoribosylanthranilate isomerase activity
EKO29_RS07605	COG0512	Glutamine amidotransferase of anthranilate synthase
EKO29_RS07610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EKO29_RS07620	COG0009	L-threonylcarbamoyladenylate synthase
EKO29_RS07625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EKO29_RS07630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EKO29_RS07635	COG1187	pseudouridine synthase activity
EKO29_RS07640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EKO29_RS07650	COG2951	lytic endotransglycosylase activity
EKO29_RS07655	COG2983	Belongs to the UPF0260 family
EKO29_RS07665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EKO29_RS07670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EKO29_RS07705	COG0420	3'-5' exonuclease activity
EKO29_RS07710	COG0419	ATPase involved in DNA repair
EKO29_RS07740	COG1228	amidohydrolase
EKO29_RS07750	COG1720	tRNA m6t6A37 methyltransferase activity
EKO29_RS07760	COG1301	dicarboxylic acid transport
EKO29_RS07765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EKO29_RS07765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EKO29_RS07770	COG0489	protein tyrosine kinase activity
EKO29_RS07775	COG0717	Belongs to the dCTP deaminase family
EKO29_RS07815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EKO29_RS07815	COG4651	solute:proton antiporter activity
EKO29_RS07825	COG4181	ATPase activity
EKO29_RS07830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EKO29_RS07835	COG0628	permease
EKO29_RS07840	COG3655	Transcriptional regulator
EKO29_RS07855	COG2056	Na+-H+ antiporter family
EKO29_RS07880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EKO29_RS07890	COG1803	Methylglyoxal synthase
EKO29_RS07910	COG3008	intermembrane lipid transfer
EKO29_RS07910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EKO29_RS07915	COG2995	paraquat-inducible protein a
EKO29_RS07940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EKO29_RS08000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKO29_RS08015	COG1902	pentaerythritol trinitrate reductase activity
EKO29_RS08030	COG1523	belongs to the glycosyl hydrolase 13 family
EKO29_RS08035	COG1501	Belongs to the glycosyl hydrolase 31 family
EKO29_RS08085	COG1115	amino acid carrier protein
EKO29_RS08115	COG2354	Protein conserved in bacteria
EKO29_RS08130	COG0123	including yeast histone deacetylase and acetoin utilization protein
EKO29_RS08135	COG0427	acetyl-CoA hydrolase
EKO29_RS08165	COG5002	protein histidine kinase activity
EKO29_RS08165	COG2198	Histidine kinase
EKO29_RS08165	COG0784	Response regulator, receiver
EKO29_RS08170	COG3437	response regulator, receiver
EKO29_RS08180	COG2199	diguanylate cyclase activity
EKO29_RS08180	COG2203	Gaf domain
EKO29_RS08200	COG0456	acetyltransferase
EKO29_RS08210	COG4774	siderophore transport
EKO29_RS08215	COG0443	Heat shock 70 kDa protein
EKO29_RS08250	COG0328	RNA-DNA hybrid ribonuclease activity
EKO29_RS08255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EKO29_RS08285	COG4989	oxidoreductase activity
EKO29_RS08290	COG0826	peptidase U32
EKO29_RS08310	COG1640	4-alpha-glucanotransferase
EKO29_RS08325	COG0058	SHG alpha-glucan phosphorylase activity
EKO29_RS08330	COG1609	Transcriptional regulator
EKO29_RS08355	COG0242	peptide deformylase activity
EKO29_RS08360	COG2814	Major facilitator Superfamily
EKO29_RS08365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EKO29_RS08400	COG0326	Molecular chaperone. Has ATPase activity
EKO29_RS08405	COG0563	adenylate kinase activity
EKO29_RS08415	COG2153	protein acetylation
EKO29_RS08430	COG0140	phosphoribosyl-ATP diphosphatase activity
EKO29_RS08430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EKO29_RS08435	COG0107	imidazoleglycerol-phosphate synthase activity
EKO29_RS08440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EKO29_RS08445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EKO29_RS08450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EKO29_RS08450	COG0131	Imidazoleglycerol-phosphate dehydratase
EKO29_RS08460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EKO29_RS08465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EKO29_RS08475	COG1199	ATP-dependent helicase activity
EKO29_RS08500	COG0318	PFAM AMP-dependent synthetase and ligase
EKO29_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS08520	COG0616	signal peptide processing
EKO29_RS08530	COG0583	DNA-binding transcription factor activity
EKO29_RS08540	COG2363	Small membrane protein
EKO29_RS08545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EKO29_RS08550	COG0473	3-isopropylmalate dehydrogenase activity
EKO29_RS08560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EKO29_RS08565	COG1611	Belongs to the LOG family
EKO29_RS08595	COG3064	Membrane
EKO29_RS08650	COG2171	N-acyltransferase activity
EKO29_RS08655	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EKO29_RS08660	COG0024	Methionine aminopeptidase
EKO29_RS08670	COG0052	Belongs to the universal ribosomal protein uS2 family
EKO29_RS08680	COG0528	UMP kinase activity
EKO29_RS08685	COG0233	cytoplasmic translational termination
EKO29_RS08690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EKO29_RS08695	COG0575	Belongs to the CDS family
EKO29_RS08700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EKO29_RS08705	COG0750	zinc metalloprotease
EKO29_RS08715	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EKO29_RS08725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EKO29_RS08730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EKO29_RS08735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EKO29_RS08740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EKO29_RS08750	COG0825	malonyl-CoA metabolic process
EKO29_RS08755	COG0037	tRNA processing
EKO29_RS08760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EKO29_RS08765	COG2824	Alkylphosphonate utilization operon protein PhnA
EKO29_RS08775	COG0697	spore germination
EKO29_RS08795	COG4681	YaeQ
EKO29_RS08800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EKO29_RS08855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EKO29_RS08860	COG4660	Part of a membrane complex involved in electron transport
EKO29_RS08865	COG4659	FMN binding
EKO29_RS08870	COG4658	electron transport chain
EKO29_RS08875	COG4656	Part of a membrane complex involved in electron transport
EKO29_RS08880	COG2878	Part of a membrane complex involved in electron transport
EKO29_RS08885	COG4657	Part of a membrane complex involved in electron transport
EKO29_RS08890	COG2200	EAL domain
EKO29_RS08895	COG0779	Required for maturation of 30S ribosomal subunits
EKO29_RS08900	COG0195	Participates in both transcription termination and antitermination
EKO29_RS08905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EKO29_RS08910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EKO29_RS08915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EKO29_RS08920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EKO29_RS08945	COG1185	polyribonucleotide nucleotidyltransferase activity
EKO29_RS08965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EKO29_RS08970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EKO29_RS08980	COG3437	response regulator, receiver
EKO29_RS08995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EKO29_RS09000	COG1053	succinate dehydrogenase
EKO29_RS09005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EKO29_RS09010	COG0567	Dehydrogenase, E1 component
EKO29_RS09015	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKO29_RS09020	COG0045	succinate-CoA ligase (ADP-forming) activity
EKO29_RS09025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EKO29_RS09030	COG2856	Zn peptidase
EKO29_RS09080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EKO29_RS09085	COG1230	cation diffusion facilitator family transporter
EKO29_RS09130	COG2995	paraquat-inducible protein a
EKO29_RS09140	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EKO29_RS09145	COG0436	Aminotransferase
EKO29_RS09155	COG0442	prolyl-tRNA aminoacylation
EKO29_RS09165	COG2501	S4 domain
EKO29_RS09180	COG3437	response regulator, receiver
EKO29_RS09180	COG0784	Response regulator, receiver
EKO29_RS09220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKO29_RS09225	COG1393	Belongs to the ArsC family
EKO29_RS09235	COG0857	belongs to the CobB CobQ family
EKO29_RS09235	COG0280	phosphate acetyltransferase
EKO29_RS09245	COG3092	negative regulation of chromosome organization
EKO29_RS09250	COG2226	methyltransferase
EKO29_RS09255	COG0708	Exodeoxyribonuclease III
EKO29_RS09260	COG0312	modulator of DNA gyrase
EKO29_RS09265	COG0312	modulator of DNA gyrase
EKO29_RS09275	COG0714	Associated with various cellular activities
EKO29_RS09340	COG2132	Multicopper oxidase
EKO29_RS09355	COG0789	Transcriptional regulator
EKO29_RS09360	COG2217	Heavy metal translocating P-type atpase
EKO29_RS09400	COG0745	RESPONSE REGULATOR receiver
EKO29_RS09405	COG2205	protein histidine kinase activity
EKO29_RS09435	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS09450	COG0642	Histidine kinase
EKO29_RS09455	COG4633	Protein conserved in bacteria
EKO29_RS09480	COG2350	Protein conserved in bacteria
EKO29_RS09490	COG0006	proline dipeptidase activity
EKO29_RS09505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EKO29_RS09510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EKO29_RS09510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EKO29_RS09525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EKO29_RS09545	COG2920	part of a sulfur-relay system
EKO29_RS09565	COG0670	Belongs to the BI1 family
EKO29_RS09570	COG0519	Catalyzes the synthesis of GMP from XMP
EKO29_RS09590	COG1674	ftsk spoiiie
EKO29_RS09625	COG1104	cysteine desulfurase activity
EKO29_RS09640	COG0672	)-iron permease
EKO29_RS09685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EKO29_RS09695	COG0642	Histidine kinase
EKO29_RS09700	COG0745	RESPONSE REGULATOR receiver
EKO29_RS09710	COG0463	Glycosyl transferase, family 2
EKO29_RS09720	COG1858	cytochrome C peroxidase
EKO29_RS09755	COG0745	RESPONSE REGULATOR receiver
EKO29_RS09760	COG0811	peptide transport
EKO29_RS09775	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EKO29_RS09800	COG3082	Protein of unknown function (DUF1414)
EKO29_RS09805	COG3081	Nucleoid-associated protein
EKO29_RS09810	COG0418	dihydroorotase activity
EKO29_RS09860	COG4771	TonB-dependent receptor
EKO29_RS09870	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS09875	COG1902	pentaerythritol trinitrate reductase activity
EKO29_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS09895	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS09910	COG0183	Belongs to the thiolase family
EKO29_RS09915	COG0318	PFAM AMP-dependent synthetase and ligase
EKO29_RS09920	COG2130	NADP-dependent
EKO29_RS09925	COG0243	molybdopterin cofactor binding
EKO29_RS09930	COG0542	response to heat
EKO29_RS09940	COG0596	Alpha beta hydrolase
EKO29_RS09970	COG1024	Enoyl-CoA hydratase
EKO29_RS09995	COG0778	Nitroreductase
EKO29_RS10000	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS10005	COG0386	Belongs to the glutathione peroxidase family
EKO29_RS10010	COG1846	Transcriptional regulator
EKO29_RS10020	COG0390	transport system, permease component
EKO29_RS10040	COG0534	Mate efflux family protein
EKO29_RS10080	COG1403	HNH endonuclease
EKO29_RS10090	COG2801	Transposase and inactivated derivatives
EKO29_RS10115	COG3102	Protein conserved in bacteria
EKO29_RS10120	COG1061	Type III restriction enzyme res subunit
EKO29_RS10180	COG0653	protein targeting
EKO29_RS10230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS10240	COG0583	DNA-binding transcription factor activity
EKO29_RS10245	COG0730	response to heat
EKO29_RS10270	COG0646	methionine synthase
EKO29_RS10270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EKO29_RS10280	COG1770	oligopeptidase
EKO29_RS10300	COG5001	Diguanylate cyclase
EKO29_RS10300	COG5002	protein histidine kinase activity
EKO29_RS10305	COG1454	alcohol dehydrogenase
EKO29_RS10310	COG0840	transmembrane signaling receptor activity
EKO29_RS10340	COG1187	pseudouridine synthase activity
EKO29_RS10365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS10375	COG4191	Histidine kinase
EKO29_RS10440	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS10490	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EKO29_RS10510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKO29_RS10515	COG0531	amino acid
EKO29_RS10520	COG1982	Orn Lys Arg decarboxylase major
EKO29_RS10530	COG0589	response to stress
EKO29_RS10545	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EKO29_RS10560	COG0625	glutathione transferase activity
EKO29_RS10565	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EKO29_RS10610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EKO29_RS10615	COG2226	methyltransferase
EKO29_RS10615	COG1073	alpha beta
EKO29_RS10620	COG0156	8-amino-7-oxononanoate synthase activity
EKO29_RS10625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EKO29_RS10630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EKO29_RS10640	COG0017	Asparaginyl-tRNA synthetase
EKO29_RS10645	COG0778	Nitroreductase
EKO29_RS10650	COG0616	signal peptide processing
EKO29_RS10655	COG0252	asparaginase activity
EKO29_RS10670	COG3139	Protein of unknown function (DUF1315)
EKO29_RS10750	COG2274	protein secretion by the type I secretion system
EKO29_RS10765	COG0800	Aldolase
EKO29_RS10775	COG0129	dihydroxy-acid dehydratase activity
EKO29_RS10780	COG0363	glucosamine-6-phosphate deaminase activity
EKO29_RS10785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EKO29_RS10790	COG1737	Transcriptional regulator
EKO29_RS10795	COG0469	pyruvate kinase activity
EKO29_RS10805	COG0205	6-phosphofructokinase activity
EKO29_RS10810	COG0583	DNA-binding transcription factor activity
EKO29_RS10825	COG3279	Response regulator of the LytR AlgR family
EKO29_RS10830	COG2972	Histidine kinase
EKO29_RS10845	COG3201	nicotinamide mononucleotide transporter
EKO29_RS10865	COG0537	adenosine 5'-monophosphoramidase activity
EKO29_RS10870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKO29_RS10885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EKO29_RS10890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EKO29_RS10900	COG0813	purine-nucleoside phosphorylase activity
EKO29_RS10905	COG1596	polysaccharide export
EKO29_RS10905	COG1555	photosystem II stabilization
EKO29_RS10910	COG0284	orotidine-5'-phosphate decarboxylase activity
EKO29_RS10915	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EKO29_RS10925	COG0776	regulation of translation
EKO29_RS10930	COG0539	negative regulation of cytoplasmic translation
EKO29_RS10935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EKO29_RS10940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EKO29_RS10955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKO29_RS10965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EKO29_RS10970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EKO29_RS11000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EKO29_RS11010	COG0668	transmembrane transport
EKO29_RS11015	COG2252	PERMEase
EKO29_RS11020	COG0659	secondary active sulfate transmembrane transporter activity
EKO29_RS11025	COG1309	transcriptional regulator
EKO29_RS11035	COG0402	S-adenosylhomocysteine deaminase activity
EKO29_RS11055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EKO29_RS11065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EKO29_RS11075	COG3257	ureidoglycine aminohydrolase activity
EKO29_RS11090	COG0583	DNA-binding transcription factor activity
EKO29_RS11095	COG0583	DNA-binding transcription factor activity
EKO29_RS11100	COG0189	ligase activity
EKO29_RS11110	COG0189	ligase activity
EKO29_RS11110	COG4067	protein conserved in archaea
EKO29_RS11115	COG3264	Mechanosensitive ion channel
EKO29_RS11115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EKO29_RS11130	COG4251	negative regulation of phosphorylation
EKO29_RS11135	COG0784	Response regulator, receiver
EKO29_RS11135	COG2198	Histidine kinase
EKO29_RS11135	COG0643	Histidine kinase
EKO29_RS11150	COG3300	MHYT domain
EKO29_RS11150	COG5001	Diguanylate cyclase
EKO29_RS11190	COG0729	surface antigen
EKO29_RS11195	COG0598	Magnesium transport protein CorA
EKO29_RS11200	COG2239	Acts as a magnesium transporter
EKO29_RS11215	COG3706	GGDEF domain
EKO29_RS11215	COG5001	Diguanylate cyclase
EKO29_RS11215	COG2203	Gaf domain
EKO29_RS11215	COG4251	negative regulation of phosphorylation
EKO29_RS11245	COG4771	TonB-dependent receptor
EKO29_RS11250	COG3036	rescue of stalled ribosome
EKO29_RS11265	COG2801	Transposase and inactivated derivatives
EKO29_RS11295	COG0829	nickel cation binding
EKO29_RS11300	COG0831	urea catabolic process
EKO29_RS11305	COG0832	Belongs to the urease beta subunit family
EKO29_RS11315	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EKO29_RS11320	COG0830	nickel cation binding
EKO29_RS11340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EKO29_RS11345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EKO29_RS11350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EKO29_RS11355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EKO29_RS11360	COG1674	ftsk spoiiie
EKO29_RS11360	COG0531	amino acid
EKO29_RS11370	COG0686	Belongs to the AlaDH PNT family
EKO29_RS11375	COG0492	ferredoxin-NADP+ reductase activity
EKO29_RS11385	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EKO29_RS11390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EKO29_RS11400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EKO29_RS11405	COG1278	Cold shock
EKO29_RS11420	COG1187	pseudouridine synthase activity
EKO29_RS11430	COG0482	sulfurtransferase activity
EKO29_RS11435	COG2915	High frequency lysogenization protein hflD homolog
EKO29_RS11440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EKO29_RS11445	COG2850	peptidyl-arginine hydroxylation
EKO29_RS11465	COG0247	lactate metabolic process
EKO29_RS11465	COG0277	FAD linked oxidase domain protein
EKO29_RS11470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EKO29_RS11470	COG0574	Belongs to the PEP-utilizing enzyme family
EKO29_RS11475	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EKO29_RS11480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EKO29_RS11495	COG0572	uridine kinase
EKO29_RS11500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EKO29_RS11505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EKO29_RS11510	COG1435	thymidine kinase activity
EKO29_RS11520	COG0295	cytidine deaminase activity
EKO29_RS11530	COG1309	transcriptional regulator
EKO29_RS11540	COG1785	Belongs to the alkaline phosphatase family
EKO29_RS11545	COG0626	cystathionine gamma-synthase activity
EKO29_RS11550	COG0417	DNA replication proofreading
EKO29_RS11555	COG1199	ATP-dependent helicase activity
EKO29_RS11580	COG0745	RESPONSE REGULATOR receiver
EKO29_RS11585	COG2205	protein histidine kinase activity
EKO29_RS11600	COG2801	Transposase and inactivated derivatives
EKO29_RS11615	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS11685	COG0625	glutathione transferase activity
EKO29_RS11695	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EKO29_RS11700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EKO29_RS11710	COG1012	belongs to the aldehyde dehydrogenase family
EKO29_RS11715	COG2258	MOSC domain
EKO29_RS11720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKO29_RS11725	COG0235	Class ii aldolase
EKO29_RS11730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EKO29_RS11750	COG4771	TonB-dependent receptor
EKO29_RS11790	COG0662	Cupin 2, conserved barrel domain protein
EKO29_RS11795	COG1522	sequence-specific DNA binding
EKO29_RS11805	COG0602	queuosine metabolic process
EKO29_RS11810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EKO29_RS11815	COG0527	aspartate kinase activity
EKO29_RS11825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EKO29_RS11830	COG2226	methyltransferase
EKO29_RS11840	COG0741	lytic transglycosylase activity
EKO29_RS11840	COG1388	LysM domain
EKO29_RS11850	COG0367	asparagine synthase
EKO29_RS11860	COG0167	dihydroorotate dehydrogenase activity
EKO29_RS11865	COG2902	Dehydrogenase
EKO29_RS11895	COG0308	aminopeptidase N
EKO29_RS11900	COG1757	Na H antiporter
EKO29_RS11910	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EKO29_RS11920	COG1956	GAF domain-containing protein
EKO29_RS11925	COG0251	oxidation-reduction process
EKO29_RS11940	COG2234	aminopeptidase activity
EKO29_RS11950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EKO29_RS11955	COG0372	Belongs to the citrate synthase family
EKO29_RS11960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EKO29_RS11970	COG2715	membrane protein required for spore maturation
EKO29_RS11975	COG0084	hydrolase, TatD family'
EKO29_RS11985	COG0470	DNA polymerase III
EKO29_RS11995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EKO29_RS12000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EKO29_RS12005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EKO29_RS12010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EKO29_RS12020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EKO29_RS12025	COG0416	fatty acid biosynthetic process
EKO29_RS12030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EKO29_RS12035	COG1399	metal-binding, possibly nucleic acid-binding protein
EKO29_RS12055	COG1530	ribonuclease E activity
EKO29_RS12065	COG2204	response regulator
EKO29_RS12070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EKO29_RS12080	COG4251	negative regulation of phosphorylation
EKO29_RS12080	COG5001	Diguanylate cyclase
EKO29_RS12080	COG3706	GGDEF domain
EKO29_RS12080	COG2203	Gaf domain
EKO29_RS12125	COG2067	long-chain fatty acid transport protein
EKO29_RS12175	COG0322	excinuclease ABC activity
EKO29_RS12180	COG2197	response regulator
EKO29_RS12190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EKO29_RS12195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EKO29_RS12240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EKO29_RS12250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EKO29_RS12250	COG1648	precorrin-2 dehydrogenase activity
EKO29_RS12255	COG0535	radical SAM domain protein
EKO29_RS12305	COG4783	chaperone-mediated protein folding
EKO29_RS12310	COG1393	Belongs to the ArsC family
EKO29_RS12335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EKO29_RS12340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EKO29_RS12350	COG0121	glutamine amidotransferase
EKO29_RS12355	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS12365	COG1012	belongs to the aldehyde dehydrogenase family
EKO29_RS12370	COG0667	Aldo Keto reductase
EKO29_RS12385	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS12480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EKO29_RS12515	COG0405	Gamma-glutamyltransferase
EKO29_RS12535	COG0069	glutamate synthase activity
EKO29_RS12550	COG1032	radical SAM domain protein
EKO29_RS12555	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EKO29_RS12585	COG0488	(ABC) transporter
EKO29_RS12590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EKO29_RS12605	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
EKO29_RS12610	COG0513	Belongs to the DEAD box helicase family
EKO29_RS12625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EKO29_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS12665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EKO29_RS12670	COG0604	alcohol dehydrogenase
EKO29_RS12675	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS12680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EKO29_RS12680	COG1703	isobutyryl-CoA mutase activity
EKO29_RS12680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EKO29_RS12695	COG0514	ATP-dependent DNA helicase (RecQ)
EKO29_RS12700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKO29_RS12700	COG4191	Histidine kinase
EKO29_RS12705	COG0784	Response regulator, receiver
EKO29_RS12705	COG3437	response regulator, receiver
EKO29_RS12755	COG0183	Belongs to the thiolase family
EKO29_RS12765	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS12770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EKO29_RS12775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EKO29_RS12780	COG4770	biotin carboxylase activity
EKO29_RS12790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EKO29_RS12795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EKO29_RS12825	COG0513	Belongs to the DEAD box helicase family
EKO29_RS12830	COG1115	amino acid carrier protein
EKO29_RS12835	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EKO29_RS12840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EKO29_RS12865	COG2801	Transposase and inactivated derivatives
EKO29_RS12885	COG4771	TonB-dependent receptor
EKO29_RS12890	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS12915	COG1070	Carbohydrate kinase
EKO29_RS12920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EKO29_RS12940	COG1476	TRANSCRIPTIONal
EKO29_RS12960	COG4628	conserved protein (DUF2132)
EKO29_RS12980	COG0243	molybdopterin cofactor binding
EKO29_RS12995	COG0300	oxidoreductase activity
EKO29_RS13015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKO29_RS13025	COG4628	conserved protein (DUF2132)
EKO29_RS13035	COG0427	acetyl-CoA hydrolase
EKO29_RS13075	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EKO29_RS13080	COG3228	Belongs to the MtfA family
EKO29_RS13110	COG1944	ATP diphosphatase activity
EKO29_RS13135	COG3279	Response regulator of the LytR AlgR family
EKO29_RS13140	COG3275	phosphorelay sensor kinase activity
EKO29_RS13145	COG1309	transcriptional regulator
EKO29_RS13150	COG0604	alcohol dehydrogenase
EKO29_RS13185	COG0488	(ABC) transporter
EKO29_RS13205	COG2203	Gaf domain
EKO29_RS13205	COG2199	diguanylate cyclase activity
EKO29_RS13250	COG2951	lytic endotransglycosylase activity
EKO29_RS13260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKO29_RS13265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKO29_RS13270	COG0668	transmembrane transport
EKO29_RS13285	COG1959	2 iron, 2 sulfur cluster binding
EKO29_RS13300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EKO29_RS13325	COG2076	Multidrug Resistance protein
EKO29_RS13335	COG2375	cellular response to nickel ion
EKO29_RS13370	COG1902	pentaerythritol trinitrate reductase activity
EKO29_RS13440	COG1204	response to ionizing radiation
EKO29_RS13450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EKO29_RS13450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EKO29_RS13460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EKO29_RS13465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKO29_RS13475	COG0006	proline dipeptidase activity
EKO29_RS13505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EKO29_RS13510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EKO29_RS13520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EKO29_RS13535	COG1115	amino acid carrier protein
EKO29_RS13540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EKO29_RS13555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EKO29_RS13590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EKO29_RS13595	COG0762	integral membrane protein
EKO29_RS13610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EKO29_RS13615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EKO29_RS13620	COG0590	tRNA wobble adenosine to inosine editing
EKO29_RS13625	COG3291	Pkd domain containing protein
EKO29_RS13635	COG0789	Transcriptional regulator
EKO29_RS13650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EKO29_RS13655	COG0047	phosphoribosylformylglycinamidine synthase activity
EKO29_RS13655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EKO29_RS13720	COG0778	Nitroreductase
EKO29_RS13735	COG0564	pseudouridine synthase activity
EKO29_RS13740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKO29_RS13795	COG0023	Translation Initiation Factor
EKO29_RS13820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EKO29_RS13850	COG1183	phosphatidylcholine synthase activity
EKO29_RS13855	COG0542	response to heat
EKO29_RS13860	COG1496	oxidoreductase activity
EKO29_RS13865	COG0564	pseudouridine synthase activity
EKO29_RS13870	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKO29_RS13875	COG0347	Belongs to the P(II) protein family
EKO29_RS13880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EKO29_RS13890	COG4969	Belongs to the N-Me-Phe pilin family
EKO29_RS13930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EKO29_RS13935	COG1047	Peptidyl-prolyl cis-trans
EKO29_RS13945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EKO29_RS13950	COG0196	riboflavin kinase activity
EKO29_RS13960	COG0268	Binds directly to 16S ribosomal RNA
EKO29_RS13970	COG0612	Peptidase, M16
EKO29_RS13985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EKO29_RS13990	COG0339	signal peptide processing
EKO29_RS14000	COG3148	PFAM DTW domain containing protein
EKO29_RS14010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EKO29_RS14015	COG1278	Cold shock
EKO29_RS14030	COG0681	Belongs to the peptidase S26 family
EKO29_RS14035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKO29_RS14065	COG1362	aminopeptidase activity
EKO29_RS14085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EKO29_RS14090	COG2835	tetraacyldisaccharide 4'-kinase activity
EKO29_RS14100	COG1132	(ABC) transporter
EKO29_RS14105	COG0658	competence protein
EKO29_RS14105	COG2333	competence protein COMEC
EKO29_RS14115	COG4591	ABC-type transport system involved in lipoprotein release permease component
EKO29_RS14125	COG4591	ABC-type transport system involved in lipoprotein release permease component
EKO29_RS14130	COG3590	peptidase
EKO29_RS14140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EKO29_RS14145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EKO29_RS14150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EKO29_RS14160	COG0840	transmembrane signaling receptor activity
EKO29_RS14170	COG0288	reversible hydration of carbon dioxide
EKO29_RS14180	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EKO29_RS14185	COG0848	biopolymer transport protein
EKO29_RS14190	COG0811	peptide transport
EKO29_RS14195	COG0811	peptide transport
EKO29_RS14240	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS14250	COG0583	DNA-binding transcription factor activity
EKO29_RS14255	COG0778	Nitroreductase
EKO29_RS14265	COG0513	Belongs to the DEAD box helicase family
EKO29_RS14285	COG2906	2 iron, 2 sulfur cluster binding
EKO29_RS14295	COG2193	ferroxidase activity
EKO29_RS14310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EKO29_RS14315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EKO29_RS14320	COG1862	Preprotein translocase
EKO29_RS14325	COG0343	queuine tRNA-ribosyltransferase activity
EKO29_RS14330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EKO29_RS14335	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EKO29_RS14355	COG3005	denitrification pathway
EKO29_RS14365	COG0243	molybdopterin cofactor binding
EKO29_RS14380	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKO29_RS14380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKO29_RS14385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EKO29_RS14390	COG0018	arginyl-trna synthetase
EKO29_RS14400	COG0084	hydrolase, TatD family'
EKO29_RS14410	COG0560	Phosphoserine phosphatase
EKO29_RS14425	COG0646	methionine synthase
EKO29_RS14425	COG1410	methionine synthase
EKO29_RS14475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EKO29_RS14485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EKO29_RS14490	COG4988	ABC transporter
EKO29_RS14500	COG1294	oxidase, subunit
EKO29_RS14515	COG2304	oxidoreductase activity
EKO29_RS14535	COG2855	membrane
EKO29_RS14550	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS14590	COG1012	belongs to the aldehyde dehydrogenase family
EKO29_RS14595	COG1733	regulation of RNA biosynthetic process
EKO29_RS14605	COG4807	Protein conserved in bacteria
EKO29_RS14610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EKO29_RS14635	COG1187	pseudouridine synthase activity
EKO29_RS14640	COG0826	peptidase U32
EKO29_RS14645	COG0826	peptidase U32
EKO29_RS14650	COG3154	lipid carrier protein
EKO29_RS14700	COG0783	Belongs to the Dps family
EKO29_RS14740	COG0318	PFAM AMP-dependent synthetase and ligase
EKO29_RS14755	COG2205	protein histidine kinase activity
EKO29_RS14765	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EKO29_RS14770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EKO29_RS14775	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EKO29_RS14780	COG1234	tRNA 3'-trailer cleavage
EKO29_RS14800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EKO29_RS14805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EKO29_RS14815	COG4942	peptidase
EKO29_RS14815	COG1388	LysM domain
EKO29_RS14820	COG1238	metal cluster binding
EKO29_RS14825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EKO29_RS14830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EKO29_RS14845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EKO29_RS14860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EKO29_RS14865	COG2233	PERMEase
EKO29_RS14870	COG3604	Transcriptional regulator
EKO29_RS14880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EKO29_RS14880	COG1017	nitric oxide dioxygenase activity
EKO29_RS14915	COG2832	Protein of unknown function (DUF454)
EKO29_RS14930	COG1131	(ABC) transporter
EKO29_RS14945	COG1444	tRNA N-acetyltransferase activity
EKO29_RS14950	COG0259	pyridoxamine-phosphate oxidase activity
EKO29_RS14955	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EKO29_RS14960	COG0511	ligase activity, forming carbon-carbon bonds
EKO29_RS14960	COG5016	pyruvate
EKO29_RS15000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EKO29_RS15005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EKO29_RS15015	COG0583	DNA-binding transcription factor activity
EKO29_RS15025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EKO29_RS15040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EKO29_RS15065	COG1477	protein flavinylation
EKO29_RS15070	COG2871	sodium ion transport
EKO29_RS15075	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EKO29_RS15080	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EKO29_RS15085	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EKO29_RS15090	COG1805	sodium ion transport
EKO29_RS15100	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EKO29_RS15105	COG0271	Belongs to the BolA IbaG family
EKO29_RS15120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKO29_RS15130	COG2814	Major facilitator Superfamily
EKO29_RS15145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EKO29_RS15155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EKO29_RS15160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EKO29_RS15170	COG0513	Belongs to the DEAD box helicase family
EKO29_RS15185	COG3022	response to hydroperoxide
EKO29_RS15190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EKO29_RS15235	COG3150	esterase
EKO29_RS15250	COG0494	nUDIX hydrolase
EKO29_RS15255	COG1538	Outer membrane efflux protein
EKO29_RS15260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EKO29_RS15260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EKO29_RS15265	COG1560	Kdo2-lipid A biosynthetic process
EKO29_RS15290	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EKO29_RS15295	COG3789	protein conserved in bacteria
EKO29_RS15325	COG4991	sh3 domain protein
EKO29_RS15335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EKO29_RS15345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EKO29_RS15350	COG0473	3-isopropylmalate dehydrogenase activity
EKO29_RS15355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EKO29_RS15360	COG0066	3-isopropylmalate dehydratase activity
EKO29_RS15365	COG3409	Peptidoglycan-binding domain 1 protein
EKO29_RS15365	COG3267	Type II secretory pathway component ExeA
EKO29_RS15370	COG0617	tRNA 3'-terminal CCA addition
EKO29_RS15385	COG1054	Belongs to the UPF0176 family
EKO29_RS15395	COG0306	phosphate transporter
EKO29_RS15400	COG1392	Phosphate transport regulator
EKO29_RS15405	COG0704	Plays a role in the regulation of phosphate uptake
EKO29_RS15410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EKO29_RS15415	COG0573	inorganic phosphate transmembrane transporter activity
EKO29_RS15425	COG1368	sulfuric ester hydrolase activity
EKO29_RS15440	COG2194	sulfuric ester hydrolase activity
EKO29_RS15455	COG0642	Histidine kinase
EKO29_RS15460	COG0745	RESPONSE REGULATOR receiver
EKO29_RS15475	COG0516	GMP reductase activity
EKO29_RS15475	COG0517	IMP dehydrogenase activity
EKO29_RS15480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EKO29_RS15490	COG0488	(ABC) transporter
EKO29_RS15510	COG5002	protein histidine kinase activity
EKO29_RS15515	COG0745	RESPONSE REGULATOR receiver
EKO29_RS15525	COG4191	Histidine kinase
EKO29_RS15530	COG2974	May be involved in recombination
EKO29_RS15540	COG0826	peptidase U32
EKO29_RS15545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EKO29_RS15550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EKO29_RS15555	COG0730	response to heat
EKO29_RS15565	COG0494	nUDIX hydrolase
EKO29_RS15570	COG3066	DNA modification
EKO29_RS15580	COG0676	glucose-6-phosphate 1-epimerase activity
EKO29_RS15590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EKO29_RS15595	COG3313	Fe-S protein
EKO29_RS15600	COG0659	secondary active sulfate transmembrane transporter activity
EKO29_RS15630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKO29_RS15630	COG4191	Histidine kinase
EKO29_RS15640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EKO29_RS15650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EKO29_RS15655	COG1286	toxin biosynthetic process
EKO29_RS15660	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EKO29_RS15665	COG0285	dihydrofolate synthase activity
EKO29_RS15670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EKO29_RS15675	COG0101	tRNA pseudouridine synthase activity
EKO29_RS15685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EKO29_RS15700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EKO29_RS15720	COG3101	peptidyl-lysine hydroxylation
EKO29_RS15755	COG0330	HflC and HflK could
EKO29_RS15760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKO29_RS15765	COG1522	sequence-specific DNA binding
EKO29_RS15775	COG0484	heat shock protein binding
EKO29_RS15780	COG0443	Heat shock 70 kDa protein
EKO29_RS15785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EKO29_RS15790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EKO29_RS15795	COG0497	DNA recombination
EKO29_RS15800	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EKO29_RS15805	COG2914	Belongs to the UPF0125 (RnfH) family
EKO29_RS15810	COG2867	negative regulation of translational initiation
EKO29_RS15815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EKO29_RS15825	COG0582	viral genome integration into host DNA
EKO29_RS15865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EKO29_RS15905	COG0840	transmembrane signaling receptor activity
EKO29_RS15960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EKO29_RS15970	COG0653	protein targeting
EKO29_RS15985	COG4774	siderophore transport
EKO29_RS16030	COG1522	sequence-specific DNA binding
EKO29_RS16035	COG4948	Mandelate Racemase Muconate Lactonizing
EKO29_RS16110	COG0006	proline dipeptidase activity
EKO29_RS16135	COG2854	intermembrane phospholipid transfer
EKO29_RS16145	COG0583	DNA-binding transcription factor activity
EKO29_RS16150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EKO29_RS16165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS16195	COG2203	Gaf domain
EKO29_RS16195	COG3706	GGDEF domain
EKO29_RS16195	COG4251	negative regulation of phosphorylation
EKO29_RS16195	COG5001	Diguanylate cyclase
EKO29_RS16220	COG0443	Heat shock 70 kDa protein
EKO29_RS16235	COG0822	iron-sulfur transferase activity
EKO29_RS16240	COG1104	cysteine desulfurase activity
EKO29_RS16245	COG1959	2 iron, 2 sulfur cluster binding
EKO29_RS16250	COG1045	serine acetyltransferase
EKO29_RS16260	COG0483	inositol monophosphate 1-phosphatase activity
EKO29_RS16275	COG0513	Belongs to the DEAD box helicase family
EKO29_RS16285	COG1067	ATP-dependent peptidase activity
EKO29_RS16290	COG2888	peptidyl-tyrosine sulfation
EKO29_RS16295	COG0495	leucyl-tRNA aminoacylation
EKO29_RS16300	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EKO29_RS16305	COG1466	dna polymerase III delta subunit
EKO29_RS16310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EKO29_RS16315	COG0799	negative regulation of ribosome biogenesis
EKO29_RS16320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EKO29_RS16325	COG0768	penicillin binding
EKO29_RS16330	COG0772	Belongs to the SEDS family
EKO29_RS16335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EKO29_RS16340	COG1686	Belongs to the peptidase S11 family
EKO29_RS16345	COG2921	Belongs to the UPF0250 family
EKO29_RS16350	COG0321	lipoyl(octanoyl) transferase activity
EKO29_RS16355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EKO29_RS16360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EKO29_RS16365	COG2890	protein-(glutamine-N5) methyltransferase activity
EKO29_RS16375	COG2062	phosphohistidine phosphatase, SixA
EKO29_RS16380	COG1025	Belongs to the peptidase M16 family
EKO29_RS16405	COG0183	Belongs to the thiolase family
EKO29_RS16410	COG0714	Associated with various cellular activities
EKO29_RS16425	COG2304	oxidoreductase activity
EKO29_RS16430	COG2304	oxidoreductase activity
EKO29_RS16440	COG1595	DNA-templated transcription, initiation
EKO29_RS16455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EKO29_RS16460	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EKO29_RS16465	COG1088	dTDP-glucose 4,6-dehydratase activity
EKO29_RS16480	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EKO29_RS16485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EKO29_RS16495	COG0529	Catalyzes the synthesis of activated sulfate
EKO29_RS16500	COG0471	metal ion transport
EKO29_RS16500	COG3273	potassium ion transport
EKO29_RS16505	COG2895	sulfate adenylyltransferase (ATP) activity
EKO29_RS16510	COG0175	sulfate reduction
EKO29_RS16520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EKO29_RS16560	COG0367	asparagine synthase
EKO29_RS16585	COG2089	acid synthase
EKO29_RS16600	COG1083	cytidylyl-transferase
EKO29_RS16605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EKO29_RS16610	COG1086	Polysaccharide biosynthesis protein
EKO29_RS16615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EKO29_RS16620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EKO29_RS16625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EKO29_RS16645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EKO29_RS16660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EKO29_RS16665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EKO29_RS16670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKO29_RS16675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EKO29_RS16680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EKO29_RS16685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EKO29_RS16690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EKO29_RS16700	COG2853	Lipoprotein
EKO29_RS16710	COG0835	chemotaxis
EKO29_RS16720	COG1192	Involved in chromosome partitioning
EKO29_RS16725	COG1360	Flagellar Motor Protein
EKO29_RS16730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EKO29_RS16740	COG0643	Histidine kinase
EKO29_RS16740	COG0784	Response regulator, receiver
EKO29_RS16740	COG2198	Histidine kinase
EKO29_RS16745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EKO29_RS16780	COG1684	flagellar biosynthetic protein fliR
EKO29_RS16785	COG1987	bacterial-type flagellum assembly
EKO29_RS16835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EKO29_RS16840	COG1766	The M ring may be actively involved in energy transduction
EKO29_RS16845	COG1677	Flagellar hook-basal body complex protein FliE
EKO29_RS16880	COG1083	cytidylyl-transferase
EKO29_RS16890	COG2089	acid synthase
EKO29_RS16895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EKO29_RS16900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EKO29_RS16925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EKO29_RS16935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EKO29_RS16945	COG1705	Flagellar rod assembly protein muramidase FlgJ
EKO29_RS16945	COG3951	Flagellar rod assembly protein muramidase FlgJ
EKO29_RS16950	COG1706	bacterial-type flagellum-dependent cell motility
EKO29_RS16955	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EKO29_RS16970	COG1749	Flagellar hook protein flgE
EKO29_RS16975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EKO29_RS16985	COG1815	bacterial-type flagellum-dependent cell motility
EKO29_RS16990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EKO29_RS16995	COG0835	chemotaxis
EKO29_RS16995	COG0784	Response regulator, receiver
EKO29_RS17000	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
EKO29_RS17035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EKO29_RS17040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EKO29_RS17045	COG0126	phosphoglycerate kinase activity
EKO29_RS17055	COG0668	transmembrane transport
EKO29_RS17100	COG1346	cytolysis
EKO29_RS17125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EKO29_RS17135	COG3122	Protein conserved in bacteria
EKO29_RS17140	COG2010	Cytochrome c
EKO29_RS17140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EKO29_RS17150	COG0746	molybdenum cofactor guanylyltransferase activity
EKO29_RS17170	COG1605	Chorismate mutase
EKO29_RS17170	COG0077	Prephenate dehydratase
EKO29_RS17185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKO29_RS17190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS17205	COG0840	transmembrane signaling receptor activity
EKO29_RS17210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EKO29_RS17225	COG0287	Prephenate dehydrogenase
EKO29_RS17225	COG1605	Chorismate mutase
EKO29_RS17230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EKO29_RS17235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EKO29_RS17245	COG0335	large ribosomal subunit rRNA binding
EKO29_RS17250	COG0336	Belongs to the RNA methyltransferase TrmD family
EKO29_RS17255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EKO29_RS17260	COG0228	four-way junction DNA binding
EKO29_RS17265	COG0697	spore germination
EKO29_RS17275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EKO29_RS17285	COG4137	Cytochrome C assembly protein
EKO29_RS17290	COG4536	flavin adenine dinucleotide binding
EKO29_RS17300	COG2918	glutathione biosynthetic process
EKO29_RS17305	COG1757	Na H antiporter
EKO29_RS17310	COG0564	pseudouridine synthase activity
EKO29_RS17315	COG0733	neurotransmitter:sodium symporter activity
EKO29_RS17320	COG1666	GTP binding
EKO29_RS17330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EKO29_RS17335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKO29_RS17335	COG0301	tRNA thio-modification
EKO29_RS17345	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EKO29_RS17350	COG1722	exodeoxyribonuclease VII activity
EKO29_RS17355	COG0142	geranyltranstransferase activity
EKO29_RS17360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EKO29_RS17385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EKO29_RS17385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EKO29_RS17390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EKO29_RS17395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EKO29_RS17405	COG1595	DNA-templated transcription, initiation
EKO29_RS17415	COG4555	ABC transporter
EKO29_RS17430	COG1272	protein, Hemolysin III
EKO29_RS17440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EKO29_RS17460	COG0179	Fumarylacetoacetate (FAA) hydrolase
EKO29_RS17475	COG2205	protein histidine kinase activity
EKO29_RS17485	COG2204	response regulator
EKO29_RS17495	COG0545	Peptidyl-prolyl cis-trans isomerase
EKO29_RS17505	COG0668	transmembrane transport
EKO29_RS17515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EKO29_RS17540	COG0784	Response regulator, receiver
EKO29_RS17540	COG2205	protein histidine kinase activity
EKO29_RS17540	COG5002	protein histidine kinase activity
EKO29_RS17545	COG2203	Gaf domain
EKO29_RS17545	COG3706	GGDEF domain
EKO29_RS17545	COG4251	negative regulation of phosphorylation
EKO29_RS17545	COG5001	Diguanylate cyclase
EKO29_RS17555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EKO29_RS17590	COG4974	Belongs to the 'phage' integrase family
EKO29_RS17640	COG0795	lipopolysaccharide-transporting ATPase activity
EKO29_RS17645	COG0795	lipopolysaccharide-transporting ATPase activity
EKO29_RS17650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EKO29_RS17655	COG2927	DNA polymerase III (CHI subunit)
EKO29_RS17660	COG0525	valine-tRNA ligase activity
EKO29_RS17665	COG1278	Cold shock
EKO29_RS17680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EKO29_RS17690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EKO29_RS17700	COG4133	protoheme IX ABC transporter activity
EKO29_RS17705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EKO29_RS17710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EKO29_RS17715	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EKO29_RS17720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EKO29_RS17725	COG1309	transcriptional regulator
EKO29_RS17730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS17735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EKO29_RS17740	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
EKO29_RS17745	COG0204	Acyl-transferase
EKO29_RS17750	COG2853	Lipoprotein
EKO29_RS17765	COG0745	RESPONSE REGULATOR receiver
EKO29_RS17770	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS17795	COG0564	pseudouridine synthase activity
EKO29_RS17815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS17820	COG3112	Uncharacterised protein family (UPF0231)
EKO29_RS17840	COG1131	(ABC) transporter
EKO29_RS17845	COG0842	Transport permease protein
EKO29_RS17855	COG1049	propionate catabolic process, 2-methylcitrate cycle
EKO29_RS17870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKO29_RS17875	COG0508	dehydrogenase complex catalyzes the overall conversion of
EKO29_RS17880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EKO29_RS17915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EKO29_RS17920	COG1459	type II secretion system
EKO29_RS17925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EKO29_RS17935	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EKO29_RS17950	COG0653	protein targeting
EKO29_RS17955	COG0739	heme binding
EKO29_RS17970	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EKO29_RS17975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EKO29_RS17980	COG0849	cell division
EKO29_RS17985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EKO29_RS17995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EKO29_RS18005	COG0772	Belongs to the SEDS family
EKO29_RS18015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EKO29_RS18020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EKO29_RS18030	COG0768	penicillin binding
EKO29_RS18035	COG3116	cell division
EKO29_RS18040	COG0275	rRNA processing
EKO29_RS18045	COG2001	Belongs to the MraZ family
EKO29_RS18050	COG3842	ATPase activity
EKO29_RS18060	COG1840	ABC-type Fe3 transport system, periplasmic component
EKO29_RS18075	COG0039	L-malate dehydrogenase activity
EKO29_RS18080	COG1438	arginine binding
EKO29_RS18085	COG2837	iron assimilation
EKO29_RS18090	COG0004	ammonium transporteR
EKO29_RS18095	COG0347	Belongs to the P(II) protein family
EKO29_RS18110	COG2827	Endonuclease containing a URI domain
EKO29_RS18130	COG1793	dna ligase
EKO29_RS18135	COG1280	lysine exporter protein (LysE YggA)
EKO29_RS18140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EKO29_RS18155	COG2234	aminopeptidase activity
EKO29_RS18160	COG5001	Diguanylate cyclase
EKO29_RS18160	COG3300	MHYT domain
EKO29_RS18180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS18190	COG2996	Protein conserved in bacteria
EKO29_RS18195	COG0312	modulator of DNA gyrase
EKO29_RS18200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKO29_RS18205	COG3164	Protein of unknown function
EKO29_RS18210	COG1530	ribonuclease E activity
EKO29_RS18220	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EKO29_RS18225	COG1792	Involved in formation and maintenance of cell shape
EKO29_RS18230	COG1077	Cell shape determining protein MreB Mrl
EKO29_RS18260	COG4969	Belongs to the N-Me-Phe pilin family
EKO29_RS18265	COG2165	general secretion pathway protein
EKO29_RS18275	COG1459	type II secretion system
EKO29_RS18280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EKO29_RS18290	COG3409	Peptidoglycan-binding domain 1 protein
EKO29_RS18290	COG3267	Type II secretory pathway component ExeA
EKO29_RS18320	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EKO29_RS18325	COG2199	diguanylate cyclase activity
EKO29_RS18325	COG2200	EAL domain
EKO29_RS18330	COG0359	binds to the 23S rRNA
EKO29_RS18335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EKO29_RS18340	COG2965	DNA replication, synthesis of RNA primer
EKO29_RS18355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKO29_RS18360	COG0557	exoribonuclease II activity
EKO29_RS18365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EKO29_RS18385	COG0316	Belongs to the HesB IscA family
EKO29_RS18400	COG1981	membrane
EKO29_RS18405	COG0540	Belongs to the ATCase OTCase family
EKO29_RS18410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EKO29_RS18415	COG2969	positive regulation of protein catabolic process
EKO29_RS18420	COG0625	glutathione transferase activity
EKO29_RS18425	COG2857	Cytochrome c1
EKO29_RS18430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EKO29_RS18435	COG0723	plastoquinol--plastocyanin reductase activity
EKO29_RS18440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EKO29_RS18445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EKO29_RS18450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EKO29_RS18460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EKO29_RS18480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EKO29_RS18485	COG5007	Belongs to the BolA IbaG family
EKO29_RS18495	COG2854	intermembrane phospholipid transfer
EKO29_RS18500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EKO29_RS18505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EKO29_RS18510	COG1127	ABC transporter
EKO29_RS18520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EKO29_RS18520	COG0517	IMP dehydrogenase activity
EKO29_RS18525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EKO29_RS18540	COG1137	ATPase activity
EKO29_RS18545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EKO29_RS18560	COG1660	Displays ATPase and GTPase activities
EKO29_RS18565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EKO29_RS18570	COG2239	Acts as a magnesium transporter
EKO29_RS18575	COG0312	modulator of DNA gyrase
EKO29_RS18590	COG0019	diaminopimelate decarboxylase activity
EKO29_RS18600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKO29_RS18615	COG4191	Histidine kinase
EKO29_RS18615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EKO29_RS18620	COG0745	RESPONSE REGULATOR receiver
EKO29_RS18630	COG1469	GTP cyclohydrolase I activity
EKO29_RS18635	COG0070	glutamate synthase
EKO29_RS18635	COG0069	glutamate synthase activity
EKO29_RS18635	COG0067	glutamate synthase
EKO29_RS18640	COG0493	'glutamate synthase
EKO29_RS18645	COG2203	Gaf domain
EKO29_RS18645	COG3706	GGDEF domain
EKO29_RS18645	COG5001	Diguanylate cyclase
EKO29_RS18645	COG4251	negative regulation of phosphorylation
EKO29_RS18665	COG0640	Transcriptional regulator
EKO29_RS18700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EKO29_RS18710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKO29_RS18725	COG1966	Carbon starvation protein
EKO29_RS18775	COG3901	Regulator of nitric oxide reductase transcription
EKO29_RS18775	COG0348	domain, Protein
EKO29_RS18780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EKO29_RS18785	COG0739	heme binding
EKO29_RS18800	COG1090	epimerase
EKO29_RS18820	COG1845	cytochrome c oxidase, subunit III
EKO29_RS18830	COG0629	single-stranded DNA binding
EKO29_RS18850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EKO29_RS18865	COG0446	pyridine nucleotide-disulphide oxidoreductase
EKO29_RS18865	COG1902	pentaerythritol trinitrate reductase activity
EKO29_RS18875	COG2814	Major facilitator Superfamily
EKO29_RS18880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EKO29_RS18890	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EKO29_RS18900	COG1187	pseudouridine synthase activity
EKO29_RS18910	COG3647	Membrane
EKO29_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
EKO29_RS18945	COG3547	Transposase (IS116 IS110 IS902 family)
EKO29_RS18990	COG0163	prenyltransferase activity
EKO29_RS18995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EKO29_RS19000	COG0633	Ferredoxin
EKO29_RS19000	COG3217	Mosc domain protein beta barrel domain protein
EKO29_RS19005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EKO29_RS19010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EKO29_RS19015	COG1984	allophanate hydrolase subunit 2
EKO29_RS19035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EKO29_RS19045	COG1012	belongs to the aldehyde dehydrogenase family
EKO29_RS19080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EKO29_RS19085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EKO29_RS19090	COG0348	domain, Protein
EKO29_RS19110	COG0678	peroxiredoxin activity
EKO29_RS19110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EKO29_RS19130	COG0346	lactoylglutathione lyase activity
EKO29_RS19135	COG3078	GTPase activator activity
EKO29_RS19155	COG0840	transmembrane signaling receptor activity
EKO29_RS19175	COG0741	lytic transglycosylase activity
EKO29_RS19220	COG3706	GGDEF domain
EKO29_RS19230	COG0840	transmembrane signaling receptor activity
EKO29_RS19250	COG1960	acyl-CoA dehydrogenase activity
EKO29_RS19275	COG4251	negative regulation of phosphorylation
EKO29_RS19275	COG5001	Diguanylate cyclase
EKO29_RS19275	COG3706	GGDEF domain
EKO29_RS19275	COG2203	Gaf domain
EKO29_RS19285	COG2201	protein-glutamate methylesterase activity
EKO29_RS19295	COG2937	Belongs to the GPAT DAPAT family
EKO29_RS19305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EKO29_RS19325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EKO29_RS19330	COG1063	alcohol dehydrogenase
EKO29_RS19335	COG0156	8-amino-7-oxononanoate synthase activity
EKO29_RS19350	COG1519	Transferase
EKO29_RS19365	COG0859	PFAM glycosyl transferase family 9
EKO29_RS19370	COG3642	lipopolysaccharide core region biosynthetic process
EKO29_RS19375	COG1309	transcriptional regulator
EKO29_RS19385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EKO29_RS19390	COG1278	Cold shock
EKO29_RS19400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EKO29_RS19405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EKO29_RS19430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EKO29_RS19435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EKO29_RS19440	COG2003	Belongs to the UPF0758 family
EKO29_RS19445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EKO29_RS19450	COG1309	transcriptional regulator
EKO29_RS19455	COG2195	Cleaves the N-terminal amino acid of tripeptides
EKO29_RS19465	COG5002	protein histidine kinase activity
EKO29_RS19475	COG0840	transmembrane signaling receptor activity
EKO29_RS19485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EKO29_RS19495	COG0517	IMP dehydrogenase activity
EKO29_RS19495	COG0617	tRNA 3'-terminal CCA addition
EKO29_RS19495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EKO29_RS19515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS19535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EKO29_RS19540	COG2885	chlorophyll binding
EKO29_RS19545	COG0612	Peptidase, M16
EKO29_RS19550	COG4221	oxidoreductase activity
EKO29_RS19570	COG1448	Aminotransferase
EKO29_RS19575	COG3437	response regulator, receiver
EKO29_RS19575	COG3850	Histidine kinase
EKO29_RS19575	COG4999	Histidine kinase
EKO29_RS19575	COG2205	protein histidine kinase activity
EKO29_RS19580	COG3437	response regulator, receiver
EKO29_RS19585	COG0194	GDP metabolic process
EKO29_RS19590	COG1758	RNA polymerase activity
EKO29_RS19595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EKO29_RS19605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKO29_RS19610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EKO29_RS19620	COG2226	methyltransferase
EKO29_RS19630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EKO29_RS19645	COG3706	GGDEF domain
EKO29_RS19660	COG2311	Membrane
EKO29_RS19690	COG0606	chelatase, subunit chli
EKO29_RS19700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EKO29_RS19705	COG3123	guanosine phosphorylase activity
EKO29_RS19715	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EKO29_RS19720	COG0204	Acyl-transferase
EKO29_RS19725	COG0668	transmembrane transport
EKO29_RS19730	COG1946	Acyl-CoA thioesterase
EKO29_RS19755	COG3706	GGDEF domain
EKO29_RS19760	COG1683	Conserved Protein
EKO29_RS19780	COG2050	protein possibly involved in aromatic compounds catabolism
EKO29_RS19785	COG2962	Rard protein
EKO29_RS19795	COG0210	DNA helicase
EKO29_RS19800	COG1011	Hydrolase
EKO29_RS19810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EKO29_RS19815	COG0019	diaminopimelate decarboxylase activity
EKO29_RS19825	COG1965	Belongs to the frataxin family
EKO29_RS19830	COG0181	hydroxymethylbilane synthase activity
EKO29_RS19835	COG1587	Uroporphyrinogen-III synthase
EKO29_RS19840	COG2959	enzyme of heme biosynthesis
EKO29_RS19885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EKO29_RS19900	COG3118	belongs to the thioredoxin family
EKO29_RS19910	COG0248	Ppx GppA phosphatase
EKO29_RS19925	COG0084	hydrolase, TatD family'
EKO29_RS19935	COG0805	protein transport
EKO29_RS19940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EKO29_RS19945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EKO29_RS19970	COG2177	Part of the ABC transporter FtsEX involved in
EKO29_RS19975	COG2884	Cell division ATP-binding protein ftsE
EKO29_RS19980	COG0552	protein localization to endoplasmic reticulum
EKO29_RS19985	COG0742	ribosomal rna small subunit methyltransferase
EKO29_RS19995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EKO29_RS20005	COG0010	Belongs to the arginase family
EKO29_RS20015	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EKO29_RS20030	COG1846	Transcriptional regulator
EKO29_RS20030	COG0456	acetyltransferase
EKO29_RS20075	COG4771	TonB-dependent receptor
EKO29_RS20100	COG2204	response regulator
EKO29_RS20110	COG4251	negative regulation of phosphorylation
EKO29_RS20115	COG0784	Response regulator, receiver
EKO29_RS20120	COG2205	protein histidine kinase activity
EKO29_RS20120	COG0784	Response regulator, receiver
EKO29_RS20135	COG1803	Methylglyoxal synthase
EKO29_RS20135	COG1597	lipid kinase activity
EKO29_RS20140	COG0668	transmembrane transport
EKO29_RS20155	COG0842	Transport permease protein
EKO29_RS20165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EKO29_RS20205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EKO29_RS20210	COG1349	DNA-binding transcription factor activity
EKO29_RS20215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EKO29_RS20220	COG2183	response to ionizing radiation
EKO29_RS20225	COG1280	lysine exporter protein (LysE YggA)
EKO29_RS20265	COG1595	DNA-templated transcription, initiation
EKO29_RS20270	COG2353	YceI-like domain
EKO29_RS20275	COG3038	cytochrome b561
EKO29_RS20295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EKO29_RS20300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EKO29_RS20305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EKO29_RS20310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EKO29_RS20315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EKO29_RS20325	COG0356	it plays a direct role in the translocation of protons across the membrane
EKO29_RS20335	COG1475	DNA binding
EKO29_RS20340	COG1192	Involved in chromosome partitioning
EKO29_RS20345	COG0357	Ribosomal RNA small subunit methyltransferase G
EKO29_RS20350	COG0445	tRNA wobble uridine modification
EKO29_RS20355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EKO29_RS20360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EKO29_RS20370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EKO29_RS20375	COG0594	ribonuclease P activity
EKO29_RS20380	COG0230	Belongs to the bacterial ribosomal protein bL34 family