locus-tag	class	description
B5D82_RS00085	COG1032	radical SAM domain protein
B5D82_RS00095	COG1459	type II secretion system
B5D82_RS00105	COG2165	general secretion pathway protein
B5D82_RS00110	COG2165	general secretion pathway protein
B5D82_RS00115	COG2165	general secretion pathway protein
B5D82_RS00160	COG1077	Cell shape determining protein MreB Mrl
B5D82_RS00165	COG1792	Involved in formation and maintenance of cell shape
B5D82_RS00170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B5D82_RS00180	COG1530	ribonuclease E activity
B5D82_RS00185	COG3164	Protein of unknown function
B5D82_RS00190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5D82_RS00195	COG0312	modulator of DNA gyrase
B5D82_RS00200	COG2996	Protein conserved in bacteria
B5D82_RS00210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5D82_RS00215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5D82_RS00230	COG5001	Diguanylate cyclase
B5D82_RS00230	COG3300	MHYT domain
B5D82_RS00240	COG2234	aminopeptidase activity
B5D82_RS00250	COG0733	neurotransmitter:sodium symporter activity
B5D82_RS00255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5D82_RS00260	COG1280	lysine exporter protein (LysE YggA)
B5D82_RS00265	COG1793	dna ligase
B5D82_RS00305	COG0004	ammonium transporteR
B5D82_RS00310	COG2837	iron assimilation
B5D82_RS00315	COG1438	arginine binding
B5D82_RS00320	COG0039	L-malate dehydrogenase activity
B5D82_RS00325	COG3291	Pkd domain containing protein
B5D82_RS00335	COG1840	ABC-type Fe3 transport system, periplasmic component
B5D82_RS00345	COG3842	ATPase activity
B5D82_RS00350	COG2001	Belongs to the MraZ family
B5D82_RS00355	COG0275	rRNA processing
B5D82_RS00360	COG3116	cell division
B5D82_RS00365	COG0768	penicillin binding
B5D82_RS00370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5D82_RS00375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B5D82_RS00380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5D82_RS00390	COG0772	Belongs to the SEDS family
B5D82_RS00400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5D82_RS00410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B5D82_RS00415	COG0849	cell division
B5D82_RS00420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5D82_RS00425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B5D82_RS00435	COG0739	heme binding
B5D82_RS00440	COG0653	protein targeting
B5D82_RS00460	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B5D82_RS00470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B5D82_RS00475	COG1459	type II secretion system
B5D82_RS00480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5D82_RS00485	COG4969	Belongs to the N-Me-Phe pilin family
B5D82_RS00500	COG3023	N-Acetylmuramoyl-L-alanine amidase
B5D82_RS00515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B5D82_RS00520	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5D82_RS00525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5D82_RS00530	COG1506	peptidase
B5D82_RS00540	COG1049	propionate catabolic process, 2-methylcitrate cycle
B5D82_RS00565	COG3112	Uncharacterised protein family (UPF0231)
B5D82_RS00580	COG0564	pseudouridine synthase activity
B5D82_RS00585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5D82_RS00590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B5D82_RS00605	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS00610	COG0745	RESPONSE REGULATOR receiver
B5D82_RS00620	COG2853	Lipoprotein
B5D82_RS00625	COG0204	Acyl-transferase
B5D82_RS00630	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B5D82_RS00635	COG4771	TonB-dependent receptor
B5D82_RS00640	COG0457	Tetratricopeptide repeat
B5D82_RS00665	COG1309	transcriptional regulator
B5D82_RS00680	COG1024	Enoyl-CoA hydratase
B5D82_RS00685	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS00695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B5D82_RS00700	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5D82_RS00705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5D82_RS00710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5D82_RS00725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B5D82_RS00730	COG1278	Cold shock
B5D82_RS00735	COG0525	valine-tRNA ligase activity
B5D82_RS00740	COG2927	DNA polymerase III (CHI subunit)
B5D82_RS00745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5D82_RS00750	COG0795	lipopolysaccharide-transporting ATPase activity
B5D82_RS00755	COG0795	lipopolysaccharide-transporting ATPase activity
B5D82_RS00775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5D82_RS00785	COG4771	TonB-dependent receptor
B5D82_RS00800	COG4251	negative regulation of phosphorylation
B5D82_RS00815	COG2022	thiamine diphosphate biosynthetic process
B5D82_RS00830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B5D82_RS00835	COG0668	transmembrane transport
B5D82_RS00845	COG0545	Peptidyl-prolyl cis-trans isomerase
B5D82_RS00850	COG2204	response regulator
B5D82_RS00860	COG2205	protein histidine kinase activity
B5D82_RS00875	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5D82_RS00885	COG3706	GGDEF domain
B5D82_RS00905	COG1272	protein, Hemolysin III
B5D82_RS00920	COG4555	ABC transporter
B5D82_RS00930	COG1595	DNA-templated transcription, initiation
B5D82_RS00940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5D82_RS00945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B5D82_RS00950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5D82_RS00950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5D82_RS00965	COG0154	amidase activity
B5D82_RS00970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5D82_RS00975	COG0142	geranyltranstransferase activity
B5D82_RS00980	COG1722	exodeoxyribonuclease VII activity
B5D82_RS00985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5D82_RS00995	COG0301	tRNA thio-modification
B5D82_RS00995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5D82_RS01000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5D82_RS01010	COG1666	GTP binding
B5D82_RS01015	COG0733	neurotransmitter:sodium symporter activity
B5D82_RS01020	COG0564	pseudouridine synthase activity
B5D82_RS01025	COG1757	Na H antiporter
B5D82_RS01030	COG2918	glutathione biosynthetic process
B5D82_RS01045	COG4536	flavin adenine dinucleotide binding
B5D82_RS01050	COG4137	Cytochrome C assembly protein
B5D82_RS01055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5D82_RS01060	COG0697	spore germination
B5D82_RS01065	COG0228	four-way junction DNA binding
B5D82_RS01070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B5D82_RS01075	COG0336	Belongs to the RNA methyltransferase TrmD family
B5D82_RS01080	COG0335	large ribosomal subunit rRNA binding
B5D82_RS01090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5D82_RS01095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5D82_RS01100	COG0287	Prephenate dehydrogenase
B5D82_RS01100	COG1605	Chorismate mutase
B5D82_RS01125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5D82_RS01135	COG0077	Prephenate dehydratase
B5D82_RS01135	COG1605	Chorismate mutase
B5D82_RS01150	COG0746	molybdenum cofactor guanylyltransferase activity
B5D82_RS01160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5D82_RS01160	COG2010	Cytochrome c
B5D82_RS01165	COG3122	Protein conserved in bacteria
B5D82_RS01175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5D82_RS01185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5D82_RS01190	COG0583	DNA-binding transcription factor activity
B5D82_RS01195	COG1595	DNA-templated transcription, initiation
B5D82_RS01220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5D82_RS01225	COG1346	cytolysis
B5D82_RS01245	COG4771	TonB-dependent receptor
B5D82_RS01250	COG2207	Transcriptional regulator
B5D82_RS01255	COG0625	glutathione transferase activity
B5D82_RS01270	COG1132	(ABC) transporter
B5D82_RS01295	COG4251	negative regulation of phosphorylation
B5D82_RS01310	COG3530	Putative quorum-sensing-regulated virulence factor
B5D82_RS01340	COG0840	transmembrane signaling receptor activity
B5D82_RS01350	COG2967	ApaG domain
B5D82_RS01355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B5D82_RS01360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B5D82_RS01365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5D82_RS01370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B5D82_RS01380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B5D82_RS01385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B5D82_RS01415	COG0668	transmembrane transport
B5D82_RS01425	COG0126	phosphoglycerate kinase activity
B5D82_RS01430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5D82_RS01435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B5D82_RS01470	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B5D82_RS01475	COG0784	Response regulator, receiver
B5D82_RS01475	COG0835	chemotaxis
B5D82_RS01485	COG1815	bacterial-type flagellum-dependent cell motility
B5D82_RS01505	COG4787	bacterial-type flagellum-dependent cell motility
B5D82_RS01515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B5D82_RS01520	COG1706	bacterial-type flagellum-dependent cell motility
B5D82_RS01525	COG3951	Flagellar rod assembly protein muramidase FlgJ
B5D82_RS01525	COG1705	Flagellar rod assembly protein muramidase FlgJ
B5D82_RS01535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B5D82_RS01550	COG1334	flagellar protein FlaG
B5D82_RS01600	COG1677	Flagellar hook-basal body complex protein FliE
B5D82_RS01605	COG1766	The M ring may be actively involved in energy transduction
B5D82_RS01610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B5D82_RS01660	COG1987	bacterial-type flagellum assembly
B5D82_RS01665	COG1684	flagellar biosynthetic protein fliR
B5D82_RS01670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B5D82_RS01700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B5D82_RS01705	COG0643	Histidine kinase
B5D82_RS01705	COG0784	Response regulator, receiver
B5D82_RS01705	COG2198	Histidine kinase
B5D82_RS01715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5D82_RS01720	COG1360	Flagellar Motor Protein
B5D82_RS01725	COG1192	Involved in chromosome partitioning
B5D82_RS01735	COG0835	chemotaxis
B5D82_RS01745	COG2853	Lipoprotein
B5D82_RS01760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5D82_RS01765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5D82_RS01770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B5D82_RS01775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B5D82_RS01780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5D82_RS01785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B5D82_RS01790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B5D82_RS01810	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B5D82_RS01830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5D82_RS01835	COG1051	belongs to the nudix hydrolase family
B5D82_RS01850	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B5D82_RS01855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5D82_RS01860	COG1086	Polysaccharide biosynthesis protein
B5D82_RS01865	COG1083	cytidylyl-transferase
B5D82_RS01875	COG2089	acid synthase
B5D82_RS01910	COG0438	transferase activity, transferring glycosyl groups
B5D82_RS01915	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B5D82_RS01935	COG1091	dTDP-4-dehydrorhamnose reductase activity
B5D82_RS01940	COG1088	dTDP-glucose 4,6-dehydratase activity
B5D82_RS01945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B5D82_RS01955	COG0175	sulfate reduction
B5D82_RS01965	COG2895	sulfate adenylyltransferase (ATP) activity
B5D82_RS01970	COG0471	metal ion transport
B5D82_RS01970	COG3273	potassium ion transport
B5D82_RS01975	COG0529	Catalyzes the synthesis of activated sulfate
B5D82_RS01985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B5D82_RS01990	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B5D82_RS01995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5D82_RS02005	COG1595	DNA-templated transcription, initiation
B5D82_RS02015	COG2304	oxidoreductase activity
B5D82_RS02035	COG0714	Associated with various cellular activities
B5D82_RS02040	COG0183	Belongs to the thiolase family
B5D82_RS02045	COG1024	Enoyl-CoA hydratase
B5D82_RS02045	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5D82_RS02065	COG1025	Belongs to the peptidase M16 family
B5D82_RS02070	COG2062	phosphohistidine phosphatase, SixA
B5D82_RS02075	COG2840	Smr protein MutS2
B5D82_RS02080	COG2890	protein-(glutamine-N5) methyltransferase activity
B5D82_RS02085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5D82_RS02090	COG2814	Major facilitator Superfamily
B5D82_RS02095	COG1196	nuclear chromosome segregation
B5D82_RS02105	COG0732	type I restriction modification DNA specificity domain
B5D82_RS02115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5D82_RS02125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5D82_RS02145	COG4974	Belongs to the 'phage' integrase family
B5D82_RS02165	COG1858	cytochrome C peroxidase
B5D82_RS02180	COG1610	YqeY-like protein
B5D82_RS02185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B5D82_RS02190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5D82_RS02195	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B5D82_RS02205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B5D82_RS02210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5D82_RS02210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B5D82_RS02215	COG1968	undecaprenyl-diphosphatase activity
B5D82_RS02220	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS02235	COG3118	belongs to the thioredoxin family
B5D82_RS02245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5D82_RS02250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B5D82_RS02255	COG0321	lipoyl(octanoyl) transferase activity
B5D82_RS02260	COG2921	Belongs to the UPF0250 family
B5D82_RS02265	COG1686	Belongs to the peptidase S11 family
B5D82_RS02270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B5D82_RS02275	COG0772	Belongs to the SEDS family
B5D82_RS02280	COG0768	penicillin binding
B5D82_RS02285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B5D82_RS02290	COG0799	negative regulation of ribosome biogenesis
B5D82_RS02295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B5D82_RS02300	COG1466	dna polymerase III delta subunit
B5D82_RS02310	COG0495	leucyl-tRNA aminoacylation
B5D82_RS02315	COG2888	peptidyl-tyrosine sulfation
B5D82_RS02320	COG1067	ATP-dependent peptidase activity
B5D82_RS02325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5D82_RS02330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5D82_RS02335	COG0649	NAD binding
B5D82_RS02335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5D82_RS02355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B5D82_RS02360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5D82_RS02370	COG0713	ATP synthesis coupled electron transport
B5D82_RS02375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B5D82_RS02385	COG1007	ATP synthesis coupled electron transport
B5D82_RS02395	COG0513	Belongs to the DEAD box helicase family
B5D82_RS02410	COG0483	inositol monophosphate 1-phosphatase activity
B5D82_RS02420	COG1045	serine acetyltransferase
B5D82_RS02425	COG1959	2 iron, 2 sulfur cluster binding
B5D82_RS02430	COG1104	cysteine desulfurase activity
B5D82_RS02435	COG0822	iron-sulfur transferase activity
B5D82_RS02450	COG0443	Heat shock 70 kDa protein
B5D82_RS02460	COG0612	Peptidase, M16
B5D82_RS02465	COG3706	GGDEF domain
B5D82_RS02465	COG2203	Gaf domain
B5D82_RS02465	COG5001	Diguanylate cyclase
B5D82_RS02465	COG4251	negative regulation of phosphorylation
B5D82_RS02475	COG1063	alcohol dehydrogenase
B5D82_RS02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5D82_RS02500	COG2366	antibiotic biosynthetic process
B5D82_RS02505	COG2854	intermembrane phospholipid transfer
B5D82_RS02515	COG0006	proline dipeptidase activity
B5D82_RS02555	COG3300	MHYT domain
B5D82_RS02555	COG5001	Diguanylate cyclase
B5D82_RS02560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5D82_RS02575	COG4948	Mandelate Racemase Muconate Lactonizing
B5D82_RS02580	COG1522	sequence-specific DNA binding
B5D82_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS02640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B5D82_RS02645	COG3022	response to hydroperoxide
B5D82_RS02655	COG1473	amidohydrolase
B5D82_RS02660	COG0513	Belongs to the DEAD box helicase family
B5D82_RS02670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5D82_RS02675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B5D82_RS02685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B5D82_RS02695	COG2814	Major facilitator Superfamily
B5D82_RS02725	COG0271	Belongs to the BolA IbaG family
B5D82_RS02735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5D82_RS02740	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B5D82_RS02745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5D82_RS02750	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B5D82_RS02755	COG1805	sodium ion transport
B5D82_RS02760	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B5D82_RS02765	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B5D82_RS02770	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B5D82_RS02775	COG2871	sodium ion transport
B5D82_RS02780	COG1477	protein flavinylation
B5D82_RS02810	COG0010	Belongs to the arginase family
B5D82_RS02825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5D82_RS02845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B5D82_RS02850	COG0830	nickel cation binding
B5D82_RS02855	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B5D82_RS02860	COG0804	urea catabolic process
B5D82_RS02865	COG0832	Belongs to the urease beta subunit family
B5D82_RS02870	COG0831	urea catabolic process
B5D82_RS02875	COG0829	nickel cation binding
B5D82_RS02885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5D82_RS02890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B5D82_RS02935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B5D82_RS02940	COG0259	pyridoxamine-phosphate oxidase activity
B5D82_RS02950	COG1444	tRNA N-acetyltransferase activity
B5D82_RS02955	COG1131	(ABC) transporter
B5D82_RS02970	COG2832	Protein of unknown function (DUF454)
B5D82_RS02980	COG0504	CTP synthase activity
B5D82_RS02990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5D82_RS02990	COG1017	nitric oxide dioxygenase activity
B5D82_RS03000	COG3604	Transcriptional regulator
B5D82_RS03010	COG4251	negative regulation of phosphorylation
B5D82_RS03015	COG0784	Response regulator, receiver
B5D82_RS03020	COG4251	negative regulation of phosphorylation
B5D82_RS03030	COG2233	PERMEase
B5D82_RS03035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B5D82_RS03045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B5D82_RS03060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B5D82_RS03065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5D82_RS03070	COG1238	metal cluster binding
B5D82_RS03075	COG1388	LysM domain
B5D82_RS03075	COG4942	peptidase
B5D82_RS03085	COG4172	Belongs to the ABC transporter superfamily
B5D82_RS03090	COG4172	Belongs to the ABC transporter superfamily
B5D82_RS03095	COG4171	peptide transport system, permease
B5D82_RS03100	COG4168	peptide transport system, permease
B5D82_RS03105	COG0747	negative chemotaxis
B5D82_RS03110	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B5D82_RS03115	COG1842	Phage shock protein A
B5D82_RS03130	COG3106	COG3106 Predicted ATPase
B5D82_RS03135	COG3768	UPF0283 membrane protein
B5D82_RS03145	COG2154	pterin-4-alpha-carbinolamine dehydratase
B5D82_RS03155	COG0625	glutathione transferase activity
B5D82_RS03195	COG3273	potassium ion transport
B5D82_RS03195	COG0471	metal ion transport
B5D82_RS03210	COG0730	response to heat
B5D82_RS03235	COG0811	peptide transport
B5D82_RS03240	COG0811	peptide transport
B5D82_RS03245	COG0848	biopolymer transport protein
B5D82_RS03265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5D82_RS03270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B5D82_RS03275	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B5D82_RS03285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5D82_RS03310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5D82_RS03350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5D82_RS03400	COG0672	)-iron permease
B5D82_RS03405	COG0789	Transcriptional regulator
B5D82_RS03410	COG1230	cation diffusion facilitator family transporter
B5D82_RS03440	COG1061	Type III restriction enzyme res subunit
B5D82_RS03470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5D82_RS03475	COG0210	DNA helicase
B5D82_RS03490	COG3483	tryptophan 2,3-dioxygenase activity
B5D82_RS03495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5D82_RS03515	COG0662	Cupin 2, conserved barrel domain protein
B5D82_RS03545	COG0071	Belongs to the small heat shock protein (HSP20) family
B5D82_RS03550	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B5D82_RS03555	COG2201	protein-glutamate methylesterase activity
B5D82_RS03560	COG3706	GGDEF domain
B5D82_RS03570	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B5D82_RS03575	COG0577	efflux transmembrane transporter activity
B5D82_RS03585	COG1136	(ABC) transporter
B5D82_RS03590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5D82_RS03595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B5D82_RS03600	COG4535	Mg2 and Co2 transporter CorC
B5D82_RS03605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B5D82_RS03610	COG1702	phosphate starvation-inducible protein PhoH
B5D82_RS03615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5D82_RS03635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5D82_RS03670	COG0012	GTP binding
B5D82_RS03675	COG0193	aminoacyl-tRNA hydrolase activity
B5D82_RS03680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B5D82_RS03695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B5D82_RS03700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B5D82_RS03705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5D82_RS03710	COG2890	protein-(glutamine-N5) methyltransferase activity
B5D82_RS03720	COG2912	Transglutaminase-like superfamily
B5D82_RS03730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B5D82_RS03735	COG1301	dicarboxylic acid transport
B5D82_RS03765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B5D82_RS03790	COG0745	RESPONSE REGULATOR receiver
B5D82_RS03795	COG0023	Translation Initiation Factor
B5D82_RS03850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5D82_RS03855	COG0564	pseudouridine synthase activity
B5D82_RS03885	COG0047	phosphoribosylformylglycinamidine synthase activity
B5D82_RS03885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5D82_RS03890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B5D82_RS03895	COG0590	tRNA wobble adenosine to inosine editing
B5D82_RS03900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5D82_RS03905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B5D82_RS03915	COG0762	integral membrane protein
B5D82_RS03920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B5D82_RS03950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B5D82_RS03960	COG0189	ligase activity
B5D82_RS03965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B5D82_RS03970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5D82_RS03975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B5D82_RS03985	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B5D82_RS03995	COG0006	proline dipeptidase activity
B5D82_RS04000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5D82_RS04005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5D82_RS04010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5D82_RS04020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5D82_RS04020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5D82_RS04065	COG4628	conserved protein (DUF2132)
B5D82_RS04070	COG2133	pyrroloquinoline quinone binding
B5D82_RS04085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5D82_RS04125	COG0668	transmembrane transport
B5D82_RS04140	COG0436	Aminotransferase
B5D82_RS04145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5D82_RS04160	COG0583	DNA-binding transcription factor activity
B5D82_RS04165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B5D82_RS04175	COG2951	lytic endotransglycosylase activity
B5D82_RS04225	COG1309	transcriptional regulator
B5D82_RS04235	COG0577	efflux transmembrane transporter activity
B5D82_RS04240	COG1136	(ABC) transporter
B5D82_RS04255	COG4191	Histidine kinase
B5D82_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS04270	COG3710	Transcriptional regulator
B5D82_RS04275	COG1119	ATPase activity
B5D82_RS04325	COG0488	(ABC) transporter
B5D82_RS04340	COG0604	alcohol dehydrogenase
B5D82_RS04345	COG1309	transcriptional regulator
B5D82_RS04350	COG3275	phosphorelay sensor kinase activity
B5D82_RS04380	COG1944	ATP diphosphatase activity
B5D82_RS04385	COG3228	Belongs to the MtfA family
B5D82_RS04405	COG0513	Belongs to the DEAD box helicase family
B5D82_RS04415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5D82_RS04425	COG1714	RDD family
B5D82_RS04430	COG1070	Carbohydrate kinase
B5D82_RS04435	COG0300	oxidoreductase activity
B5D82_RS04480	COG0583	DNA-binding transcription factor activity
B5D82_RS04525	COG4628	conserved protein (DUF2132)
B5D82_RS04540	COG1070	Carbohydrate kinase
B5D82_RS04550	COG0420	3'-5' exonuclease activity
B5D82_RS04555	COG0419	ATPase involved in DNA repair
B5D82_RS04565	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B5D82_RS04585	COG0402	S-adenosylhomocysteine deaminase activity
B5D82_RS04590	COG0697	spore germination
B5D82_RS04595	COG1720	tRNA m6t6A37 methyltransferase activity
B5D82_RS04610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5D82_RS04610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5D82_RS04620	COG0717	Belongs to the dCTP deaminase family
B5D82_RS04655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5D82_RS04655	COG4651	solute:proton antiporter activity
B5D82_RS04665	COG4181	ATPase activity
B5D82_RS04670	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B5D82_RS04675	COG0628	permease
B5D82_RS04685	COG2056	Na+-H+ antiporter family
B5D82_RS04770	COG0534	Mate efflux family protein
B5D82_RS04775	COG0307	riboflavin synthase, alpha
B5D82_RS04785	COG3001	Fructosamine kinase
B5D82_RS04790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B5D82_RS04795	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B5D82_RS04805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5D82_RS04805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5D82_RS04835	COG1760	l-serine dehydratase
B5D82_RS04850	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5D82_RS04850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5D82_RS04865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5D82_RS04870	COG0583	DNA-binding transcription factor activity
B5D82_RS04880	COG0017	Asparaginyl-tRNA synthetase
B5D82_RS04890	COG0840	transmembrane signaling receptor activity
B5D82_RS04900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B5D82_RS04910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5D82_RS04915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B5D82_RS04920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B5D82_RS04925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B5D82_RS04930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B5D82_RS04935	COG0347	Belongs to the P(II) protein family
B5D82_RS04940	COG0004	ammonium transporteR
B5D82_RS04945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5D82_RS04950	COG0072	phenylalanine-tRNA ligase activity
B5D82_RS04950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5D82_RS04955	COG0776	regulation of translation
B5D82_RS04965	COG5265	(ABC) transporter
B5D82_RS04990	COG0037	tRNA processing
B5D82_RS05000	COG0589	response to stress
B5D82_RS05005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5D82_RS05020	COG2217	Heavy metal translocating P-type atpase
B5D82_RS05030	COG2010	Cytochrome c
B5D82_RS05045	COG3278	Belongs to the heme-copper respiratory oxidase family
B5D82_RS05055	COG1280	lysine exporter protein (LysE YggA)
B5D82_RS05070	COG1477	protein flavinylation
B5D82_RS05105	COG0534	Mate efflux family protein
B5D82_RS05110	COG0556	nucleotide-excision repair
B5D82_RS05120	COG0386	Belongs to the glutathione peroxidase family
B5D82_RS05130	COG2084	Dehydrogenase
B5D82_RS05135	COG2925	Exonuclease
B5D82_RS05180	COG2084	Dehydrogenase
B5D82_RS05220	COG0270	DNA (cytosine-5-)-methyltransferase activity
B5D82_RS05255	COG0535	radical SAM domain protein
B5D82_RS05270	COG2205	protein histidine kinase activity
B5D82_RS05280	COG3901	Regulator of nitric oxide reductase transcription
B5D82_RS05280	COG0348	domain, Protein
B5D82_RS05320	COG1131	(ABC) transporter
B5D82_RS05335	COG0583	DNA-binding transcription factor activity
B5D82_RS05345	COG1484	DNA-dependent DNA replication
B5D82_RS05385	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS05390	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS05395	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS05405	COG1881	PFAM PEBP family protein
B5D82_RS05410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B5D82_RS05420	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS05425	COG0183	Belongs to the thiolase family
B5D82_RS05430	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5D82_RS05430	COG1024	Enoyl-CoA hydratase
B5D82_RS05440	COG1024	Enoyl-CoA hydratase
B5D82_RS05500	COG1640	4-alpha-glucanotransferase
B5D82_RS05515	COG0058	SHG alpha-glucan phosphorylase activity
B5D82_RS05525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B5D82_RS05530	COG0033	Phosphoglucomutase
B5D82_RS05550	COG0166	Belongs to the GPI family
B5D82_RS05565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5D82_RS05580	COG0395	ABC-type sugar transport system, permease component
B5D82_RS05620	COG0545	Peptidyl-prolyl cis-trans isomerase
B5D82_RS05630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5D82_RS05635	COG0505	Belongs to the CarA family
B5D82_RS05640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5D82_RS05645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5D82_RS05655	COG1534	Rna-binding protein
B5D82_RS05660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B5D82_RS05670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B5D82_RS05675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5D82_RS05680	COG0149	triose-phosphate isomerase activity
B5D82_RS05685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5D82_RS05695	COG4783	chaperone-mediated protein folding
B5D82_RS05715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B5D82_RS05720	COG4136	ATPase activity
B5D82_RS05725	COG4135	transport system, permease component
B5D82_RS05730	COG4134	Bacterial extracellular solute-binding protein
B5D82_RS05775	COG3784	Protein of unknown function (DUF1318)
B5D82_RS05790	COG0400	carboxylic ester hydrolase activity
B5D82_RS05805	COG2135	peptidase activity
B5D82_RS05870	COG0823	Involved in the tonB-independent uptake of proteins
B5D82_RS05870	COG4946	Tricorn protease homolog
B5D82_RS05870	COG1506	peptidase
B5D82_RS05875	COG1199	ATP-dependent helicase activity
B5D82_RS05875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5D82_RS05890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B5D82_RS05900	COG3008	intermembrane lipid transfer
B5D82_RS05900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B5D82_RS05905	COG2995	paraquat-inducible protein a
B5D82_RS05910	COG1573	uracil-dna glycosylase
B5D82_RS05920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5D82_RS05930	COG0840	transmembrane signaling receptor activity
B5D82_RS05945	COG1501	Belongs to the glycosyl hydrolase 31 family
B5D82_RS05970	COG1115	amino acid carrier protein
B5D82_RS05985	COG2354	Protein conserved in bacteria
B5D82_RS06005	COG0123	including yeast histone deacetylase and acetoin utilization protein
B5D82_RS06010	COG0427	acetyl-CoA hydrolase
B5D82_RS06035	COG2199	diguanylate cyclase activity
B5D82_RS06035	COG2203	Gaf domain
B5D82_RS06055	COG0456	acetyltransferase
B5D82_RS06065	COG0840	transmembrane signaling receptor activity
B5D82_RS06075	COG3706	GGDEF domain
B5D82_RS06080	COG0514	ATP-dependent DNA helicase (RecQ)
B5D82_RS06085	COG4774	siderophore transport
B5D82_RS06090	COG3128	pkhd-type hydroxylase
B5D82_RS06105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5D82_RS06105	COG1703	isobutyryl-CoA mutase activity
B5D82_RS06105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5D82_RS06110	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS06115	COG0604	alcohol dehydrogenase
B5D82_RS06120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B5D82_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS06170	COG3706	GGDEF domain
B5D82_RS06175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5D82_RS06185	COG0513	Belongs to the DEAD box helicase family
B5D82_RS06190	COG3710	Transcriptional regulator
B5D82_RS06200	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B5D82_RS06205	COG0488	(ABC) transporter
B5D82_RS06210	COG1032	radical SAM domain protein
B5D82_RS06215	COG1032	radical SAM domain protein
B5D82_RS06355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5D82_RS06365	COG3267	Type II secretory pathway component ExeA
B5D82_RS06365	COG3409	Peptidoglycan-binding domain 1 protein
B5D82_RS06400	COG0359	binds to the 23S rRNA
B5D82_RS06405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B5D82_RS06410	COG2965	DNA replication, synthesis of RNA primer
B5D82_RS06420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5D82_RS06425	COG0557	exoribonuclease II activity
B5D82_RS06430	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B5D82_RS06435	COG3706	GGDEF domain
B5D82_RS06450	COG0316	Belongs to the HesB IscA family
B5D82_RS06465	COG1981	membrane
B5D82_RS06470	COG0540	Belongs to the ATCase OTCase family
B5D82_RS06475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5D82_RS06480	COG2969	positive regulation of protein catabolic process
B5D82_RS06485	COG0625	glutathione transferase activity
B5D82_RS06490	COG2857	Cytochrome c1
B5D82_RS06495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B5D82_RS06500	COG0723	plastoquinol--plastocyanin reductase activity
B5D82_RS06505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B5D82_RS06510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5D82_RS06515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5D82_RS06535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5D82_RS06540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5D82_RS06545	COG5007	Belongs to the BolA IbaG family
B5D82_RS06555	COG2854	intermembrane phospholipid transfer
B5D82_RS06560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B5D82_RS06565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B5D82_RS06570	COG1127	ABC transporter
B5D82_RS06580	COG0517	IMP dehydrogenase activity
B5D82_RS06580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5D82_RS06600	COG1137	ATPase activity
B5D82_RS06605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B5D82_RS06620	COG1660	Displays ATPase and GTPase activities
B5D82_RS06625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5D82_RS06630	COG2239	Acts as a magnesium transporter
B5D82_RS06635	COG0312	modulator of DNA gyrase
B5D82_RS06650	COG0019	diaminopimelate decarboxylase activity
B5D82_RS06660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5D82_RS06675	COG4191	Histidine kinase
B5D82_RS06675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5D82_RS06680	COG0745	RESPONSE REGULATOR receiver
B5D82_RS06690	COG1469	GTP cyclohydrolase I activity
B5D82_RS06695	COG0067	glutamate synthase
B5D82_RS06695	COG0070	glutamate synthase
B5D82_RS06695	COG0069	glutamate synthase activity
B5D82_RS06700	COG0493	'glutamate synthase
B5D82_RS06705	COG5001	Diguanylate cyclase
B5D82_RS06705	COG4251	negative regulation of phosphorylation
B5D82_RS06705	COG3706	GGDEF domain
B5D82_RS06705	COG2203	Gaf domain
B5D82_RS06715	COG1917	Cupin 2, conserved barrel domain protein
B5D82_RS06715	COG4977	sequence-specific DNA binding
B5D82_RS06720	COG0640	Transcriptional regulator
B5D82_RS06755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B5D82_RS06820	COG3314	Sporulation integral membrane protein YlbJ
B5D82_RS06870	COG0348	domain, Protein
B5D82_RS06870	COG3901	Regulator of nitric oxide reductase transcription
B5D82_RS06875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5D82_RS06880	COG4942	peptidase
B5D82_RS06895	COG1090	epimerase
B5D82_RS06905	COG0629	single-stranded DNA binding
B5D82_RS06925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5D82_RS06930	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5D82_RS06930	COG1902	pentaerythritol trinitrate reductase activity
B5D82_RS06940	COG2814	Major facilitator Superfamily
B5D82_RS06945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5D82_RS06955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B5D82_RS06960	COG2808	Putative FMN-binding domain
B5D82_RS06970	COG1741	Belongs to the pirin family
B5D82_RS06985	COG3647	Membrane
B5D82_RS07020	COG0823	Involved in the tonB-independent uptake of proteins
B5D82_RS07030	COG0163	prenyltransferase activity
B5D82_RS07035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5D82_RS07040	COG0633	Ferredoxin
B5D82_RS07040	COG3217	Mosc domain protein beta barrel domain protein
B5D82_RS07045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5D82_RS07050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B5D82_RS07055	COG1984	allophanate hydrolase subunit 2
B5D82_RS07070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5D82_RS07075	COG3138	arginine N-succinyltransferase
B5D82_RS07080	COG1012	belongs to the aldehyde dehydrogenase family
B5D82_RS07090	COG0457	Tetratricopeptide repeat
B5D82_RS07135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5D82_RS07140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B5D82_RS07145	COG0348	domain, Protein
B5D82_RS07155	COG0402	S-adenosylhomocysteine deaminase activity
B5D82_RS07165	COG0678	peroxiredoxin activity
B5D82_RS07165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5D82_RS07170	COG4628	conserved protein (DUF2132)
B5D82_RS07190	COG3078	GTPase activator activity
B5D82_RS07235	COG2201	protein-glutamate methylesterase activity
B5D82_RS07245	COG2937	Belongs to the GPAT DAPAT family
B5D82_RS07250	COG0070	glutamate synthase
B5D82_RS07250	COG0069	glutamate synthase activity
B5D82_RS07250	COG0067	glutamate synthase
B5D82_RS07255	COG0493	'glutamate synthase
B5D82_RS07270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B5D82_RS07290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5D82_RS07295	COG1063	alcohol dehydrogenase
B5D82_RS07300	COG0156	8-amino-7-oxononanoate synthase activity
B5D82_RS07315	COG1519	Transferase
B5D82_RS07330	COG0859	PFAM glycosyl transferase family 9
B5D82_RS07335	COG3642	lipopolysaccharide core region biosynthetic process
B5D82_RS07340	COG1309	transcriptional regulator
B5D82_RS07350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5D82_RS07355	COG1278	Cold shock
B5D82_RS07370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5D82_RS07390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5D82_RS07395	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B5D82_RS07415	COG2003	Belongs to the UPF0758 family
B5D82_RS07420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5D82_RS07425	COG1309	transcriptional regulator
B5D82_RS07430	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5D82_RS07440	COG2205	protein histidine kinase activity
B5D82_RS07450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5D82_RS07460	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5D82_RS07460	COG0517	IMP dehydrogenase activity
B5D82_RS07480	COG3177	Filamentation induced by cAMP protein fic
B5D82_RS07485	COG1561	YicC-like family, N-terminal region
B5D82_RS07510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B5D82_RS07515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5D82_RS07535	COG1040	competence protein
B5D82_RS07545	COG0316	Belongs to the HesB IscA family
B5D82_RS07545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B5D82_RS07555	COG0534	Mate efflux family protein
B5D82_RS07560	COG1649	PFAM Uncharacterised BCR, COG1649
B5D82_RS07560	COG0726	polysaccharide deacetylase
B5D82_RS07595	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B5D82_RS07600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B5D82_RS07605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5D82_RS07610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5D82_RS07615	COG0662	Cupin 2, conserved barrel domain protein
B5D82_RS07625	COG0583	DNA-binding transcription factor activity
B5D82_RS07630	COG3634	alkyl hydroperoxide reductase activity
B5D82_RS07675	COG1253	flavin adenine dinucleotide binding
B5D82_RS07685	COG0604	alcohol dehydrogenase
B5D82_RS07690	COG1741	Belongs to the pirin family
B5D82_RS07695	COG2259	Doxx family
B5D82_RS07700	COG0583	DNA-binding transcription factor activity
B5D82_RS07735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5D82_RS07740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5D82_RS07745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5D82_RS07750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B5D82_RS07785	COG0612	Peptidase, M16
B5D82_RS07795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5D82_RS07795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5D82_RS07815	COG2132	Multicopper oxidase
B5D82_RS07820	COG0745	RESPONSE REGULATOR receiver
B5D82_RS07825	COG5002	protein histidine kinase activity
B5D82_RS07830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5D82_RS07845	COG0742	ribosomal rna small subunit methyltransferase
B5D82_RS07850	COG0678	peroxiredoxin activity
B5D82_RS07850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5D82_RS07860	COG2081	HI0933 family
B5D82_RS07865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B5D82_RS07865	COG3264	Mechanosensitive ion channel
B5D82_RS07870	COG3706	GGDEF domain
B5D82_RS07890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5D82_RS07895	COG0583	DNA-binding transcription factor activity
B5D82_RS07900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5D82_RS07930	COG0513	Belongs to the DEAD box helicase family
B5D82_RS07945	COG1671	Belongs to the UPF0178 family
B5D82_RS07950	COG0513	Belongs to the DEAD box helicase family
B5D82_RS07985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B5D82_RS08000	COG0408	coproporphyrinogen oxidase activity
B5D82_RS08010	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS08015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B5D82_RS08030	COG2922	Belongs to the Smg family
B5D82_RS08035	COG0758	DNA mediated transformation
B5D82_RS08040	COG1652	LysM domain
B5D82_RS08045	COG0242	peptide deformylase activity
B5D82_RS08055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5D82_RS08055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5D82_RS08060	COG0569	domain protein
B5D82_RS08065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5D82_RS08070	COG1739	Uncharacterized protein family UPF0029
B5D82_RS08075	COG0006	proline dipeptidase activity
B5D82_RS08085	COG0425	Belongs to the sulfur carrier protein TusA family
B5D82_RS08100	COG0751	glycine-tRNA ligase activity
B5D82_RS08105	COG0752	glycyl-tRNA synthetase alpha subunit
B5D82_RS08110	COG0187	DNA topoisomerase II activity
B5D82_RS08125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B5D82_RS08130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B5D82_RS08135	COG0594	ribonuclease P activity
B5D82_RS08140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B5D82_RS08150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B5D82_RS08155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B5D82_RS08160	COG0445	tRNA wobble uridine modification
B5D82_RS08165	COG0357	Ribosomal RNA small subunit methyltransferase G
B5D82_RS08170	COG1192	Involved in chromosome partitioning
B5D82_RS08175	COG1475	DNA binding
B5D82_RS08185	COG0356	it plays a direct role in the translocation of protons across the membrane
B5D82_RS08195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5D82_RS08200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5D82_RS08205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B5D82_RS08210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5D82_RS08215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B5D82_RS08220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B5D82_RS08235	COG3038	cytochrome b561
B5D82_RS08240	COG2353	YceI-like domain
B5D82_RS08260	COG2183	response to ionizing radiation
B5D82_RS08265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5D82_RS08275	COG1349	DNA-binding transcription factor activity
B5D82_RS08280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B5D82_RS08340	COG1404	Belongs to the peptidase S8 family
B5D82_RS08355	COG1404	Belongs to the peptidase S8 family
B5D82_RS08380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B5D82_RS08390	COG1597	lipid kinase activity
B5D82_RS08390	COG1803	Methylglyoxal synthase
B5D82_RS08400	COG2205	protein histidine kinase activity
B5D82_RS08400	COG0784	Response regulator, receiver
B5D82_RS08405	COG0784	Response regulator, receiver
B5D82_RS08410	COG4251	negative regulation of phosphorylation
B5D82_RS08420	COG2204	response regulator
B5D82_RS08455	COG0742	ribosomal rna small subunit methyltransferase
B5D82_RS08460	COG0552	protein localization to endoplasmic reticulum
B5D82_RS08465	COG2884	Cell division ATP-binding protein ftsE
B5D82_RS08470	COG2177	Part of the ABC transporter FtsEX involved in
B5D82_RS08500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5D82_RS08505	COG0805	protein transport
B5D82_RS08515	COG0084	hydrolase, TatD family'
B5D82_RS08530	COG0248	Ppx GppA phosphatase
B5D82_RS08540	COG3118	belongs to the thioredoxin family
B5D82_RS08545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B5D82_RS08550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B5D82_RS08575	COG2959	enzyme of heme biosynthesis
B5D82_RS08580	COG0181	hydroxymethylbilane synthase activity
B5D82_RS08585	COG1965	Belongs to the frataxin family
B5D82_RS08595	COG0019	diaminopimelate decarboxylase activity
B5D82_RS08600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B5D82_RS08610	COG1011	Hydrolase
B5D82_RS08615	COG0210	DNA helicase
B5D82_RS08620	COG2962	Rard protein
B5D82_RS08625	COG2050	protein possibly involved in aromatic compounds catabolism
B5D82_RS08630	COG0514	ATP-dependent DNA helicase (RecQ)
B5D82_RS08650	COG3706	GGDEF domain
B5D82_RS08670	COG1946	Acyl-CoA thioesterase
B5D82_RS08675	COG0668	transmembrane transport
B5D82_RS08680	COG0204	Acyl-transferase
B5D82_RS08685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5D82_RS08700	COG2992	FlgJ-related protein
B5D82_RS08705	COG1595	DNA-templated transcription, initiation
B5D82_RS08725	COG3123	guanosine phosphorylase activity
B5D82_RS08730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B5D82_RS08740	COG0606	chelatase, subunit chli
B5D82_RS08755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5D82_RS08760	COG0129	dihydroxy-acid dehydratase activity
B5D82_RS08795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B5D82_RS08805	COG2226	methyltransferase
B5D82_RS08810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B5D82_RS08815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5D82_RS08825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5D82_RS08830	COG1758	RNA polymerase activity
B5D82_RS08835	COG0194	GDP metabolic process
B5D82_RS08840	COG3437	response regulator, receiver
B5D82_RS08865	COG1448	Aminotransferase
B5D82_RS08880	COG0300	oxidoreductase activity
B5D82_RS08885	COG0612	Peptidase, M16
B5D82_RS08900	COG5001	Diguanylate cyclase
B5D82_RS08900	COG4251	negative regulation of phosphorylation
B5D82_RS08900	COG3706	GGDEF domain
B5D82_RS08900	COG2203	Gaf domain
B5D82_RS08915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5D82_RS08925	COG5001	Diguanylate cyclase
B5D82_RS08930	COG3132	Protein of unknown function, DUF480
B5D82_RS08950	COG0513	Belongs to the DEAD box helicase family
B5D82_RS08955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5D82_RS08975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5D82_RS08985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5D82_RS08990	COG0438	transferase activity, transferring glycosyl groups
B5D82_RS08995	COG0438	transferase activity, transferring glycosyl groups
B5D82_RS09010	COG0297	glycogen (starch) synthase activity
B5D82_RS09010	COG0438	transferase activity, transferring glycosyl groups
B5D82_RS09015	COG4772	TonB-dependent receptor
B5D82_RS09020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5D82_RS09045	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B5D82_RS09050	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5D82_RS09080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5D82_RS09085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B5D82_RS09095	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B5D82_RS09120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5D82_RS09125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B5D82_RS09130	COG0137	argininosuccinate synthase activity
B5D82_RS09135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B5D82_RS09135	COG0165	Argininosuccinate lyase
B5D82_RS09140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B5D82_RS09140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5D82_RS09155	COG3206	protein involved in exopolysaccharide biosynthesis
B5D82_RS09155	COG0489	protein tyrosine kinase activity
B5D82_RS09195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5D82_RS09215	COG0250	Participates in transcription elongation, termination and antitermination
B5D82_RS09220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B5D82_RS09225	COG0081	regulation of translation
B5D82_RS09230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5D82_RS09240	COG0085	RNA polymerase activity
B5D82_RS09245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5D82_RS09250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B5D82_RS09255	COG0049	tRNA binding
B5D82_RS09260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5D82_RS09265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5D82_RS09270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5D82_RS09275	COG0051	transcription antitermination factor activity, RNA binding
B5D82_RS09280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B5D82_RS09285	COG0088	Forms part of the polypeptide exit tunnel
B5D82_RS09290	COG0089	rRNA binding
B5D82_RS09295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5D82_RS09300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5D82_RS09305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B5D82_RS09310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B5D82_RS09315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B5D82_RS09320	COG0255	Belongs to the universal ribosomal protein uL29 family
B5D82_RS09325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5D82_RS09330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5D82_RS09335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5D82_RS09340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5D82_RS09345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5D82_RS09350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5D82_RS09355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5D82_RS09360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B5D82_RS09365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B5D82_RS09370	COG1841	ribosomal large subunit assembly
B5D82_RS09375	COG0200	Binds to the 23S rRNA
B5D82_RS09380	COG0201	protein transport
B5D82_RS09385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5D82_RS09390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5D82_RS09395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5D82_RS09400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5D82_RS09405	COG0202	RNA polymerase activity
B5D82_RS09410	COG0203	ribosomal protein L17
B5D82_RS09415	COG3954	Phosphoribulokinase
B5D82_RS09420	COG1765	OsmC-like protein
B5D82_RS09450	COG2204	response regulator
B5D82_RS09455	COG3409	Peptidoglycan-binding domain 1 protein
B5D82_RS09455	COG3267	Type II secretory pathway component ExeA
B5D82_RS09465	COG0489	protein tyrosine kinase activity
B5D82_RS09480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5D82_RS09490	COG0726	polysaccharide deacetylase
B5D82_RS09520	COG0297	glycogen (starch) synthase activity
B5D82_RS09520	COG0438	transferase activity, transferring glycosyl groups
B5D82_RS09530	COG0463	Glycosyl transferase, family 2
B5D82_RS09530	COG1216	Glycosyl transferase, family 2
B5D82_RS09590	COG0463	Glycosyl transferase, family 2
B5D82_RS09590	COG1216	Glycosyl transferase, family 2
B5D82_RS09595	COG0438	transferase activity, transferring glycosyl groups
B5D82_RS09650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B5D82_RS09670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5D82_RS09675	COG2861	carbohydrate metabolic process
B5D82_RS09680	COG4942	peptidase
B5D82_RS09685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B5D82_RS09690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5D82_RS09695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5D82_RS09700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B5D82_RS09705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B5D82_RS09710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B5D82_RS09720	COG2267	carboxylic ester hydrolase activity
B5D82_RS09725	COG2205	protein histidine kinase activity
B5D82_RS09730	COG0745	RESPONSE REGULATOR receiver
B5D82_RS09750	COG0584	glycerophosphoryl diester phosphodiesterase
B5D82_RS09755	COG0688	phosphatidylethanolamine metabolic process
B5D82_RS09760	COG1162	GTPase activity
B5D82_RS09765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B5D82_RS09795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B5D82_RS09795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5D82_RS09800	COG0802	atpase or kinase
B5D82_RS09805	COG0860	N-Acetylmuramoyl-L-alanine amidase
B5D82_RS09815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5D82_RS09820	COG1923	regulation of RNA biosynthetic process
B5D82_RS09825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5D82_RS09830	COG0330	HflC and HflK could
B5D82_RS09835	COG0330	HflC and HflK could
B5D82_RS09845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5D82_RS09850	COG0281	malic enzyme
B5D82_RS09855	COG0346	lactoylglutathione lyase activity
B5D82_RS09865	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
B5D82_RS09870	COG0626	cystathionine gamma-synthase activity
B5D82_RS09875	COG0460	homoserine dehydrogenase
B5D82_RS09875	COG0527	aspartate kinase activity
B5D82_RS09885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5D82_RS09900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5D82_RS09910	COG2315	Protein conserved in bacteria
B5D82_RS09960	COG1215	transferase activity, transferring glycosyl groups
B5D82_RS09965	COG3769	mannosylglycerate metabolic process
B5D82_RS10025	COG1595	DNA-templated transcription, initiation
B5D82_RS10030	COG3806	Anti-sigma factor
B5D82_RS10040	COG0415	Belongs to the DNA photolyase family
B5D82_RS10050	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS10065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B5D82_RS10090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5D82_RS10090	COG1648	precorrin-2 dehydrogenase activity
B5D82_RS10095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5D82_RS10100	COG2264	protein methyltransferase activity
B5D82_RS10105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5D82_RS10110	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B5D82_RS10115	COG0138	bifunctional purine biosynthesis protein purh
B5D82_RS10125	COG0151	Belongs to the GarS family
B5D82_RS10165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B5D82_RS10170	COG2204	response regulator
B5D82_RS10175	COG3852	Histidine kinase
B5D82_RS10185	COG0174	glutamine synthetase
B5D82_RS10190	COG1217	gtp-binding protein TYPA
B5D82_RS10200	COG1295	ribonuclease BN
B5D82_RS10210	COG1490	D-aminoacyl-tRNA deacylase activity
B5D82_RS10220	COG0456	acetyltransferase
B5D82_RS10230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5D82_RS10240	COG0330	HflC and HflK could
B5D82_RS10245	COG0330	HflC and HflK could
B5D82_RS10255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B5D82_RS10260	COG2986	histidine ammonia-lyase
B5D82_RS10265	COG2188	Transcriptional regulator
B5D82_RS10280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5D82_RS10295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B5D82_RS10300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B5D82_RS10310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B5D82_RS10315	COG0254	rRNA binding
B5D82_RS10335	COG0305	Participates in initiation and elongation during chromosome replication
B5D82_RS10340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5D82_RS10385	COG3085	chromosome segregation
B5D82_RS10390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5D82_RS10405	COG1842	Phage shock protein A
B5D82_RS10420	COG1024	Enoyl-CoA hydratase
B5D82_RS10445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B5D82_RS10450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B5D82_RS10455	COG3031	protein transport across the cell outer membrane
B5D82_RS10465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5D82_RS10470	COG1459	type II secretion system
B5D82_RS10485	COG2165	general secretion pathway protein
B5D82_RS10505	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B5D82_RS10540	COG1011	Hydrolase
B5D82_RS10545	COG0494	nUDIX hydrolase
B5D82_RS10550	COG1218	3'(2'),5'-bisphosphate nucleotidase
B5D82_RS10560	COG3089	Belongs to the UPF0270 family
B5D82_RS10565	COG0429	hydrolase of the alpha beta-hydrolase fold
B5D82_RS10575	COG0488	(ABC) transporter
B5D82_RS10580	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B5D82_RS10595	COG2900	Belongs to the SlyX family
B5D82_RS10605	COG0545	Peptidyl-prolyl cis-trans isomerase
B5D82_RS10615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5D82_RS10630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5D82_RS10645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5D82_RS10690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5D82_RS10695	COG0175	sulfate reduction
B5D82_RS10705	COG5001	Diguanylate cyclase
B5D82_RS10705	COG3300	MHYT domain
B5D82_RS10720	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5D82_RS10720	COG1024	Enoyl-CoA hydratase
B5D82_RS10725	COG0183	Belongs to the thiolase family
B5D82_RS10735	COG1505	serine-type exopeptidase activity
B5D82_RS10740	COG1227	inorganic diphosphatase activity
B5D82_RS10745	COG1294	oxidase, subunit
B5D82_RS10750	COG1271	oxidase subunit
B5D82_RS10760	COG0840	transmembrane signaling receptor activity
B5D82_RS10765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B5D82_RS10780	COG0697	spore germination
B5D82_RS10785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5D82_RS10790	COG2814	Major facilitator Superfamily
B5D82_RS10800	COG0439	Biotin carboxylase
B5D82_RS10805	COG0511	ligase activity, forming carbon-carbon bonds
B5D82_RS10830	COG4232	protein-disulfide reductase activity
B5D82_RS10840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B5D82_RS10880	COG1917	Cupin 2, conserved barrel domain protein
B5D82_RS10880	COG4977	sequence-specific DNA binding
B5D82_RS10890	COG1131	(ABC) transporter
B5D82_RS10905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5D82_RS10920	COG1012	belongs to the aldehyde dehydrogenase family
B5D82_RS10920	COG2030	dehydratase
B5D82_RS10930	COG1024	Enoyl-CoA hydratase
B5D82_RS10935	COG2050	protein possibly involved in aromatic compounds catabolism
B5D82_RS10940	COG0183	Belongs to the thiolase family
B5D82_RS10945	COG3396	Phenylacetate-CoA oxygenase
B5D82_RS10950	COG3460	Phenylacetate-CoA oxygenase
B5D82_RS10955	COG3396	Phenylacetate-CoA oxygenase
B5D82_RS10960	COG2151	metal-sulfur cluster biosynthetic enzyme
B5D82_RS10965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5D82_RS10970	COG3327	negative regulation of DNA-templated transcription, initiation
B5D82_RS10980	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5D82_RS10980	COG1024	Enoyl-CoA hydratase
B5D82_RS10985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5D82_RS11015	COG1902	pentaerythritol trinitrate reductase activity
B5D82_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS11060	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS11065	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS11075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5D82_RS11085	COG0384	phenazine biosynthesis protein PhzF
B5D82_RS11090	COG3977	Valine--pyruvate aminotransferase
B5D82_RS11095	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B5D82_RS11110	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS11120	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS11135	COG0346	lactoylglutathione lyase activity
B5D82_RS11150	COG1024	Enoyl-CoA hydratase
B5D82_RS11155	COG2070	2-Nitropropane dioxygenase
B5D82_RS11160	COG1024	Enoyl-CoA hydratase
B5D82_RS11165	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS11170	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS11175	COG0183	Belongs to the thiolase family
B5D82_RS11180	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS11220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5D82_RS11220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B5D82_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS11250	COG2814	Major facilitator Superfamily
B5D82_RS11255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5D82_RS11260	COG4569	acetaldehyde dehydrogenase (acetylating) activity
B5D82_RS11270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B5D82_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
B5D82_RS11295	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS11310	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS11315	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS11320	COG4771	TonB-dependent receptor
B5D82_RS11330	COG0183	Belongs to the thiolase family
B5D82_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS11340	COG4771	TonB-dependent receptor
B5D82_RS11355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5D82_RS11390	COG1509	lysine 2,3-aminomutase activity
B5D82_RS11395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5D82_RS11410	COG1131	(ABC) transporter
B5D82_RS11415	COG0842	Transport permease protein
B5D82_RS11420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B5D82_RS11425	COG0076	glutamate decarboxylase activity
B5D82_RS11430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B5D82_RS11435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B5D82_RS11440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5D82_RS11445	COG0617	tRNA 3'-terminal CCA addition
B5D82_RS11485	COG1643	Atp-dependent helicase
B5D82_RS11505	COG4771	TonB-dependent receptor
B5D82_RS11510	COG0653	protein targeting
B5D82_RS11515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5D82_RS11520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5D82_RS11530	COG2823	Periplasmic or secreted lipoprotein
B5D82_RS11535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B5D82_RS11550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B5D82_RS11570	COG1404	Belongs to the peptidase S8 family
B5D82_RS11595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B5D82_RS11595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B5D82_RS11595	COG0506	proline dehydrogenase activity
B5D82_RS11600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B5D82_RS11605	COG4242	Belongs to the peptidase S51 family
B5D82_RS11610	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5D82_RS11610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5D82_RS11615	COG0189	ligase activity
B5D82_RS11615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5D82_RS11625	COG2199	diguanylate cyclase activity
B5D82_RS11640	COG0564	pseudouridine synthase activity
B5D82_RS11655	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS11660	COG0022	dehydrogenase e1 component
B5D82_RS11670	COG1438	arginine binding
B5D82_RS11680	COG0142	geranyltranstransferase activity
B5D82_RS11685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5D82_RS11690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B5D82_RS11695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5D82_RS11700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5D82_RS11705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B5D82_RS11720	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5D82_RS11725	COG0746	molybdenum cofactor guanylyltransferase activity
B5D82_RS11735	COG0303	'Molybdopterin
B5D82_RS11745	COG0513	Belongs to the DEAD box helicase family
B5D82_RS11755	COG3141	response to X-ray
B5D82_RS11765	COG2201	protein-glutamate methylesterase activity
B5D82_RS11775	COG3706	GGDEF domain
B5D82_RS11780	COG0460	homoserine dehydrogenase
B5D82_RS11780	COG0527	aspartate kinase activity
B5D82_RS11785	COG0083	homoserine kinase activity
B5D82_RS11790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B5D82_RS11795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B5D82_RS11815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5D82_RS11835	COG0281	malic enzyme
B5D82_RS11840	COG0105	UTP biosynthetic process
B5D82_RS11845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B5D82_RS11860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5D82_RS11865	COG0124	histidyl-tRNA synthetase
B5D82_RS11870	COG2976	Protein conserved in bacteria
B5D82_RS11875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5D82_RS11880	COG1160	GTP binding
B5D82_RS11895	COG0517	IMP dehydrogenase activity
B5D82_RS11895	COG0516	GMP reductase activity
B5D82_RS11900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5D82_RS11900	COG0519	Catalyzes the synthesis of GMP from XMP
B5D82_RS11910	COG0514	ATP-dependent DNA helicase (RecQ)
B5D82_RS11925	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B5D82_RS11935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B5D82_RS11940	COG1595	DNA-templated transcription, initiation
B5D82_RS11955	COG3086	response to oxidative stress
B5D82_RS11960	COG0481	GTPase activity
B5D82_RS11965	COG0681	Belongs to the peptidase S26 family
B5D82_RS11970	COG0571	ribonuclease III activity
B5D82_RS11980	COG1381	Involved in DNA repair and RecF pathway recombination
B5D82_RS11985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B5D82_RS12000	COG4999	Histidine kinase
B5D82_RS12000	COG3850	Histidine kinase
B5D82_RS12000	COG3437	response regulator, receiver
B5D82_RS12000	COG2205	protein histidine kinase activity
B5D82_RS12010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5D82_RS12025	COG2176	DNA-directed DNA polymerase activity
B5D82_RS12030	COG3956	TIGRFAM MazG family protein
B5D82_RS12035	COG1024	Enoyl-CoA hydratase
B5D82_RS12040	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B5D82_RS12045	COG0217	transcriptional regulatory protein
B5D82_RS12055	COG2066	Belongs to the glutaminase family
B5D82_RS12065	COG0583	DNA-binding transcription factor activity
B5D82_RS12070	COG1404	Belongs to the peptidase S8 family
B5D82_RS12080	COG1716	ATPase activity
B5D82_RS12080	COG0842	Transport permease protein
B5D82_RS12080	COG1131	(ABC) transporter
B5D82_RS12095	COG2197	response regulator
B5D82_RS12110	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS12120	COG2409	Drug exporters of the RND superfamily
B5D82_RS12145	COG2015	COG2015, Alkyl sulfatase and related hydrolases
B5D82_RS12200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5D82_RS12205	COG2815	serine threonine protein kinase
B5D82_RS12205	COG0515	serine threonine protein kinase
B5D82_RS12210	COG2223	nitrite transmembrane transporter activity
B5D82_RS12215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5D82_RS12220	COG0243	molybdopterin cofactor binding
B5D82_RS12235	COG0501	Belongs to the peptidase M48B family
B5D82_RS12240	COG0673	inositol 2-dehydrogenase activity
B5D82_RS12250	COG1166	arginine decarboxylase activity
B5D82_RS12275	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B5D82_RS12280	COG1194	a g-specific adenine glycosylase
B5D82_RS12285	COG3171	Protein conserved in bacteria
B5D82_RS12290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B5D82_RS12300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5D82_RS12310	COG4191	Histidine kinase
B5D82_RS12310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5D82_RS12325	COG0659	secondary active sulfate transmembrane transporter activity
B5D82_RS12330	COG3313	Fe-S protein
B5D82_RS12335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5D82_RS12350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B5D82_RS12365	COG3066	DNA modification
B5D82_RS12370	COG0494	nUDIX hydrolase
B5D82_RS12380	COG0730	response to heat
B5D82_RS12385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5D82_RS12395	COG2974	May be involved in recombination
B5D82_RS12410	COG0745	RESPONSE REGULATOR receiver
B5D82_RS12415	COG5002	protein histidine kinase activity
B5D82_RS12435	COG0488	(ABC) transporter
B5D82_RS12440	COG2199	diguanylate cyclase activity
B5D82_RS12445	COG0516	GMP reductase activity
B5D82_RS12445	COG0517	IMP dehydrogenase activity
B5D82_RS12455	COG0573	inorganic phosphate transmembrane transporter activity
B5D82_RS12460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5D82_RS12465	COG0704	Plays a role in the regulation of phosphate uptake
B5D82_RS12470	COG1392	Phosphate transport regulator
B5D82_RS12475	COG0306	phosphate transporter
B5D82_RS12485	COG1054	Belongs to the UPF0176 family
B5D82_RS12505	COG0617	tRNA 3'-terminal CCA addition
B5D82_RS12510	COG3409	Peptidoglycan-binding domain 1 protein
B5D82_RS12510	COG3267	Type II secretory pathway component ExeA
B5D82_RS12515	COG0066	3-isopropylmalate dehydratase activity
B5D82_RS12520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5D82_RS12525	COG0473	3-isopropylmalate dehydrogenase activity
B5D82_RS12530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5D82_RS12540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B5D82_RS12555	COG4991	sh3 domain protein
B5D82_RS12565	COG1376	ErfK ybiS ycfS ynhG family protein
B5D82_RS12565	COG1388	LysM domain
B5D82_RS12575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5D82_RS12595	COG3789	protein conserved in bacteria
B5D82_RS12600	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B5D82_RS12625	COG1560	Kdo2-lipid A biosynthetic process
B5D82_RS12630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B5D82_RS12630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B5D82_RS12635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5D82_RS12655	COG1538	Outer membrane efflux protein
B5D82_RS12660	COG0494	nUDIX hydrolase
B5D82_RS12675	COG3150	esterase
B5D82_RS12695	COG4251	negative regulation of phosphorylation
B5D82_RS12695	COG5001	Diguanylate cyclase
B5D82_RS12695	COG3706	GGDEF domain
B5D82_RS12695	COG2203	Gaf domain
B5D82_RS12715	COG0582	viral genome integration into host DNA
B5D82_RS12735	COG0582	viral genome integration into host DNA
B5D82_RS12745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5D82_RS12790	COG4974	Belongs to the 'phage' integrase family
B5D82_RS12830	COG3547	Transposase (IS116 IS110 IS902 family)
B5D82_RS12855	COG1522	sequence-specific DNA binding
B5D82_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
B5D82_RS12865	COG0460	homoserine dehydrogenase
B5D82_RS12885	COG0019	diaminopimelate decarboxylase activity
B5D82_RS12890	COG0786	glutamate:sodium symporter activity
B5D82_RS12895	COG0583	DNA-binding transcription factor activity
B5D82_RS12925	COG0582	viral genome integration into host DNA
B5D82_RS12935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B5D82_RS12940	COG2867	negative regulation of translational initiation
B5D82_RS12945	COG2914	Belongs to the UPF0125 (RnfH) family
B5D82_RS12950	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5D82_RS12955	COG0497	DNA recombination
B5D82_RS12960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5D82_RS12965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5D82_RS12970	COG0443	Heat shock 70 kDa protein
B5D82_RS12975	COG0484	heat shock protein binding
B5D82_RS12985	COG1522	sequence-specific DNA binding
B5D82_RS12990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5D82_RS12995	COG0330	HflC and HflK could
B5D82_RS13000	COG3101	peptidyl-lysine hydroxylation
B5D82_RS13020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5D82_RS13045	COG0101	tRNA pseudouridine synthase activity
B5D82_RS13050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B5D82_RS13055	COG0285	dihydrofolate synthase activity
B5D82_RS13065	COG1286	toxin biosynthetic process
B5D82_RS13070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5D82_RS13095	COG1741	Belongs to the pirin family
B5D82_RS13105	COG0475	glutathione-regulated potassium exporter activity
B5D82_RS13105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5D82_RS13110	COG1741	Belongs to the pirin family
B5D82_RS13120	COG2259	Doxx family
B5D82_RS13140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5D82_RS13145	COG0215	cysteine-tRNA ligase activity
B5D82_RS13150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5D82_RS13175	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5D82_RS13180	COG0740	serine-type endopeptidase activity
B5D82_RS13185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B5D82_RS13190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5D82_RS13220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5D82_RS13225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B5D82_RS13235	COG0246	Mannitol dehydrogenase
B5D82_RS13265	COG1312	Catalyzes the dehydration of D-mannonate
B5D82_RS13270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5D82_RS13275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B5D82_RS13280	COG2186	Transcriptional regulator
B5D82_RS13300	COG2271	Major facilitator Superfamily
B5D82_RS13305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5D82_RS13310	COG0800	Aldolase
B5D82_RS13330	COG1234	tRNA 3'-trailer cleavage
B5D82_RS13340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B5D82_RS13345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B5D82_RS13355	COG1187	pseudouridine synthase activity
B5D82_RS13380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B5D82_RS13385	COG4807	Protein conserved in bacteria
B5D82_RS13395	COG2855	membrane
B5D82_RS13400	COG0583	DNA-binding transcription factor activity
B5D82_RS13440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B5D82_RS13455	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS13460	COG0657	acetylesterase activity
B5D82_RS13470	COG0784	Response regulator, receiver
B5D82_RS13470	COG2205	protein histidine kinase activity
B5D82_RS13500	COG1595	DNA-templated transcription, initiation
B5D82_RS13530	COG0735	belongs to the Fur family
B5D82_RS13540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5D82_RS13560	COG0716	FMN binding
B5D82_RS13575	COG0596	Alpha beta hydrolase
B5D82_RS13590	COG0033	Phosphoglucomutase
B5D82_RS13605	COG2988	succinylglutamate desuccinylase activity
B5D82_RS13615	COG0022	dehydrogenase e1 component
B5D82_RS13640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B5D82_RS13645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5D82_RS13650	COG2226	methyltransferase
B5D82_RS13660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B5D82_RS13665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B5D82_RS13670	COG0632	four-way junction helicase activity
B5D82_RS13675	COG2255	four-way junction helicase activity
B5D82_RS13680	COG0824	Thioesterase
B5D82_RS13685	COG0811	peptide transport
B5D82_RS13700	COG0823	Involved in the tonB-independent uptake of proteins
B5D82_RS13705	COG2885	chlorophyll binding
B5D82_RS13730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B5D82_RS13775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B5D82_RS13790	COG0583	DNA-binding transcription factor activity
B5D82_RS13795	COG1760	l-serine dehydratase
B5D82_RS13800	COG0494	nUDIX hydrolase
B5D82_RS13805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5D82_RS13825	COG0733	neurotransmitter:sodium symporter activity
B5D82_RS13830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B5D82_RS13835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B5D82_RS13855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5D82_RS13860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B5D82_RS13905	COG1012	belongs to the aldehyde dehydrogenase family
B5D82_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5D82_RS13915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5D82_RS13970	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5D82_RS13980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5D82_RS13990	COG2356	endonuclease I
B5D82_RS14000	COG2205	protein histidine kinase activity
B5D82_RS14000	COG3437	response regulator, receiver
B5D82_RS14000	COG3850	Histidine kinase
B5D82_RS14000	COG4999	Histidine kinase
B5D82_RS14005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5D82_RS14015	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B5D82_RS14020	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B5D82_RS14030	COG1492	cobalamin metabolic process
B5D82_RS14035	COG4206	TonB-dependent receptor
B5D82_RS14050	COG0406	alpha-ribazole phosphatase activity
B5D82_RS14060	COG1797	cobyrinic acid a,c-diamide synthase activity
B5D82_RS14065	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B5D82_RS14090	COG2205	protein histidine kinase activity
B5D82_RS14090	COG2198	Histidine kinase
B5D82_RS14090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5D82_RS14090	COG0784	Response regulator, receiver
B5D82_RS14095	COG2205	protein histidine kinase activity
B5D82_RS14095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5D82_RS14095	COG0784	Response regulator, receiver
B5D82_RS14095	COG2198	Histidine kinase
B5D82_RS14100	COG1476	TRANSCRIPTIONal
B5D82_RS14150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5D82_RS14155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5D82_RS14220	COG0560	Phosphoserine phosphatase
B5D82_RS14230	COG0084	hydrolase, TatD family'
B5D82_RS14240	COG0018	arginyl-trna synthetase
B5D82_RS14245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B5D82_RS14250	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5D82_RS14250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5D82_RS14265	COG0243	molybdopterin cofactor binding
B5D82_RS14275	COG3005	denitrification pathway
B5D82_RS14300	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B5D82_RS14305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B5D82_RS14310	COG0343	queuine tRNA-ribosyltransferase activity
B5D82_RS14315	COG1862	Preprotein translocase
B5D82_RS14320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5D82_RS14325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5D82_RS14335	COG3408	Glycogen debranching enzyme
B5D82_RS14335	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B5D82_RS14355	COG1757	Na H antiporter
B5D82_RS14380	COG3250	beta-galactosidase activity
B5D82_RS14385	COG2186	Transcriptional regulator
B5D82_RS14390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5D82_RS14420	COG1609	Transcriptional regulator
B5D82_RS14430	COG2193	ferroxidase activity
B5D82_RS14440	COG2906	2 iron, 2 sulfur cluster binding
B5D82_RS14445	COG0640	Transcriptional regulator
B5D82_RS14450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5D82_RS14465	COG0288	reversible hydration of carbon dioxide
B5D82_RS14470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5D82_RS14480	COG0840	transmembrane signaling receptor activity
B5D82_RS14495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5D82_RS14500	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B5D82_RS14505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5D82_RS14515	COG3590	peptidase
B5D82_RS14525	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5D82_RS14535	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5D82_RS14545	COG0658	competence protein
B5D82_RS14545	COG2333	competence protein COMEC
B5D82_RS14550	COG1132	(ABC) transporter
B5D82_RS14560	COG2835	tetraacyldisaccharide 4'-kinase activity
B5D82_RS14565	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B5D82_RS14585	COG1362	aminopeptidase activity
B5D82_RS14610	COG2816	NAD+ diphosphatase activity
B5D82_RS14645	COG1278	Cold shock
B5D82_RS14650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5D82_RS14660	COG3148	PFAM DTW domain containing protein
B5D82_RS14670	COG0339	signal peptide processing
B5D82_RS14680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5D82_RS14695	COG0268	Binds directly to 16S ribosomal RNA
B5D82_RS14700	COG0728	peptidoglycan biosynthetic process
B5D82_RS14705	COG0196	riboflavin kinase activity
B5D82_RS14710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B5D82_RS14720	COG1047	Peptidyl-prolyl cis-trans
B5D82_RS14725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B5D82_RS14760	COG4969	Belongs to the N-Me-Phe pilin family
B5D82_RS14780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5D82_RS14795	COG0542	response to heat
B5D82_RS14805	COG1183	phosphatidylcholine synthase activity
B5D82_RS14840	COG1404	Belongs to the peptidase S8 family
B5D82_RS14845	COG1404	Belongs to the peptidase S8 family
B5D82_RS14855	COG3292	Two component regulator propeller
B5D82_RS14855	COG2205	protein histidine kinase activity
B5D82_RS14855	COG0745	RESPONSE REGULATOR receiver
B5D82_RS14860	COG1451	nucleotide metabolic process
B5D82_RS14870	COG0166	Belongs to the GPI family
B5D82_RS14880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5D82_RS14885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5D82_RS14895	COG0457	Tetratricopeptide repeat
B5D82_RS14900	COG4771	TonB-dependent receptor
B5D82_RS14905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5D82_RS14910	COG1846	Transcriptional regulator
B5D82_RS14915	COG1914	H( )-stimulated, divalent metal cation uptake system
B5D82_RS14925	COG1846	Transcriptional regulator
B5D82_RS14930	COG1566	PFAM secretion protein HlyD family protein
B5D82_RS14950	COG1309	transcriptional regulator
B5D82_RS14955	COG1472	Belongs to the glycosyl hydrolase 3 family
B5D82_RS14960	COG0471	metal ion transport
B5D82_RS14970	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5D82_RS14990	COG2824	Alkylphosphonate utilization operon protein PhnA
B5D82_RS15000	COG3321	synthase
B5D82_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS15000	COG0604	alcohol dehydrogenase
B5D82_RS15030	COG1280	lysine exporter protein (LysE YggA)
B5D82_RS15075	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS15115	COG0745	RESPONSE REGULATOR receiver
B5D82_RS15125	COG4633	Protein conserved in bacteria
B5D82_RS15150	COG2719	SpoVR family
B5D82_RS15155	COG2718	Belongs to the UPF0229 family
B5D82_RS15160	COG2766	serine protein kinase
B5D82_RS15170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B5D82_RS15175	COG0450	alkyl hydroperoxide reductase
B5D82_RS15185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5D82_RS15205	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B5D82_RS15210	COG1196	nuclear chromosome segregation
B5D82_RS15220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5D82_RS15245	COG0745	RESPONSE REGULATOR receiver
B5D82_RS15250	COG5002	protein histidine kinase activity
B5D82_RS15265	COG0191	fructose-bisphosphate aldolase activity
B5D82_RS15275	COG3706	GGDEF domain
B5D82_RS15305	COG0714	Associated with various cellular activities
B5D82_RS15345	COG1288	antiporter activity
B5D82_RS15355	COG0457	Tetratricopeptide repeat
B5D82_RS15360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5D82_RS15370	COG1742	UPF0060 membrane protein
B5D82_RS15415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B5D82_RS15420	COG1074	ATP-dependent DNA helicase activity
B5D82_RS15425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5D82_RS15475	COG2211	Major facilitator Superfamily
B5D82_RS15485	COG1609	Transcriptional regulator
B5D82_RS15505	COG1024	Enoyl-CoA hydratase
B5D82_RS15505	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5D82_RS15510	COG1446	asparaginase
B5D82_RS15525	COG4109	DRTGG domain
B5D82_RS15530	COG1643	Atp-dependent helicase
B5D82_RS15540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5D82_RS15545	COG1254	Belongs to the acylphosphatase family
B5D82_RS15565	COG0314	molybdopterin synthase activity
B5D82_RS15570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B5D82_RS15615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5D82_RS15615	COG0116	Belongs to the methyltransferase superfamily
B5D82_RS15625	COG0488	(ABC) transporter
B5D82_RS15635	COG0440	acetolactate synthase activity
B5D82_RS15640	COG0028	Belongs to the TPP enzyme family
B5D82_RS15660	COG2267	carboxylic ester hydrolase activity
B5D82_RS15670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5D82_RS15675	COG0159	tryptophan synthase activity
B5D82_RS15680	COG0133	tryptophan synthase activity
B5D82_RS15685	COG0135	phosphoribosylanthranilate isomerase activity
B5D82_RS15685	COG0134	indole-3-glycerol-phosphate synthase activity
B5D82_RS15700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5D82_RS15710	COG0009	L-threonylcarbamoyladenylate synthase
B5D82_RS15715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B5D82_RS15720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5D82_RS15725	COG1187	pseudouridine synthase activity
B5D82_RS15740	COG2951	lytic endotransglycosylase activity
B5D82_RS15745	COG2983	Belongs to the UPF0260 family
B5D82_RS15770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B5D82_RS15775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B5D82_RS15780	COG1115	amino acid carrier protein
B5D82_RS15785	COG0513	Belongs to the DEAD box helicase family
B5D82_RS15795	COG3706	GGDEF domain
B5D82_RS15815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B5D82_RS15820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B5D82_RS15830	COG4770	biotin carboxylase activity
B5D82_RS15835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B5D82_RS15840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5D82_RS15845	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS15855	COG0183	Belongs to the thiolase family
B5D82_RS15880	COG0443	Heat shock 70 kDa protein
B5D82_RS15885	COG0328	RNA-DNA hybrid ribonuclease activity
B5D82_RS15890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B5D82_RS15910	COG4989	oxidoreductase activity
B5D82_RS15915	COG0826	peptidase U32
B5D82_RS15950	COG1640	4-alpha-glucanotransferase
B5D82_RS15955	COG0058	SHG alpha-glucan phosphorylase activity
B5D82_RS15960	COG1609	Transcriptional regulator
B5D82_RS15975	COG0242	peptide deformylase activity
B5D82_RS15980	COG2814	Major facilitator Superfamily
B5D82_RS15985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B5D82_RS15995	COG0326	Molecular chaperone. Has ATPase activity
B5D82_RS16000	COG0563	adenylate kinase activity
B5D82_RS16025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5D82_RS16025	COG0140	phosphoribosyl-ATP diphosphatase activity
B5D82_RS16030	COG0107	imidazoleglycerol-phosphate synthase activity
B5D82_RS16035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5D82_RS16040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5D82_RS16045	COG0131	Imidazoleglycerol-phosphate dehydratase
B5D82_RS16045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B5D82_RS16055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5D82_RS16060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5D82_RS16070	COG1199	ATP-dependent helicase activity
B5D82_RS16075	COG1214	PFAM Peptidase M22, glycoprotease
B5D82_RS16090	COG0596	Alpha beta hydrolase
B5D82_RS16095	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS16110	COG0616	signal peptide processing
B5D82_RS16115	COG0500	methyltransferase
B5D82_RS16125	COG0583	DNA-binding transcription factor activity
B5D82_RS16135	COG2363	Small membrane protein
B5D82_RS16140	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B5D82_RS16150	COG0473	3-isopropylmalate dehydrogenase activity
B5D82_RS16160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5D82_RS16165	COG1611	Belongs to the LOG family
B5D82_RS16195	COG3064	Membrane
B5D82_RS16255	COG0564	pseudouridine synthase activity
B5D82_RS16265	COG2171	N-acyltransferase activity
B5D82_RS16270	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B5D82_RS16275	COG0024	Methionine aminopeptidase
B5D82_RS16290	COG0052	Belongs to the universal ribosomal protein uS2 family
B5D82_RS16300	COG0528	UMP kinase activity
B5D82_RS16305	COG0233	cytoplasmic translational termination
B5D82_RS16310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5D82_RS16315	COG0575	Belongs to the CDS family
B5D82_RS16320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5D82_RS16325	COG0750	zinc metalloprotease
B5D82_RS16335	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
B5D82_RS16345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5D82_RS16350	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5D82_RS16355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5D82_RS16360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B5D82_RS16370	COG0825	malonyl-CoA metabolic process
B5D82_RS16380	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B5D82_RS16385	COG2824	Alkylphosphonate utilization operon protein PhnA
B5D82_RS16410	COG4681	YaeQ
B5D82_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS16425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B5D82_RS16440	COG0174	glutamine synthetase
B5D82_RS16445	COG4771	TonB-dependent receptor
B5D82_RS16450	COG0531	amino acid
B5D82_RS16455	COG0579	oxidoreductase
B5D82_RS16465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5D82_RS16470	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS16475	COG0583	DNA-binding transcription factor activity
B5D82_RS16485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5D82_RS16490	COG4660	Part of a membrane complex involved in electron transport
B5D82_RS16495	COG4659	FMN binding
B5D82_RS16500	COG4658	electron transport chain
B5D82_RS16505	COG4656	Part of a membrane complex involved in electron transport
B5D82_RS16510	COG2878	Part of a membrane complex involved in electron transport
B5D82_RS16515	COG4657	Part of a membrane complex involved in electron transport
B5D82_RS16520	COG2200	EAL domain
B5D82_RS16525	COG0779	Required for maturation of 30S ribosomal subunits
B5D82_RS16530	COG0195	Participates in both transcription termination and antitermination
B5D82_RS16535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5D82_RS16540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B5D82_RS16545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5D82_RS16550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B5D82_RS16560	COG0668	transmembrane transport
B5D82_RS16565	COG1185	polyribonucleotide nucleotidyltransferase activity
B5D82_RS16585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5D82_RS16590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B5D82_RS16595	COG3437	response regulator, receiver
B5D82_RS16610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B5D82_RS16615	COG1053	succinate dehydrogenase
B5D82_RS16620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B5D82_RS16625	COG0567	Dehydrogenase, E1 component
B5D82_RS16630	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5D82_RS16635	COG0045	succinate-CoA ligase (ADP-forming) activity
B5D82_RS16640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B5D82_RS16655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5D82_RS16660	COG0281	malic enzyme
B5D82_RS16665	COG0668	transmembrane transport
B5D82_RS16680	COG5001	Diguanylate cyclase
B5D82_RS16680	COG5002	protein histidine kinase activity
B5D82_RS16695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5D82_RS16700	COG1368	sulfuric ester hydrolase activity
B5D82_RS16705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B5D82_RS16710	COG2194	sulfuric ester hydrolase activity
B5D82_RS16720	COG5002	protein histidine kinase activity
B5D82_RS16755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5D82_RS16770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5D82_RS16775	COG0789	Transcriptional regulator
B5D82_RS16790	COG0672	)-iron permease
B5D82_RS16820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5D82_RS16825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5D82_RS16835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5D82_RS16850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5D82_RS16855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5D82_RS16860	COG0539	negative regulation of cytoplasmic translation
B5D82_RS16865	COG0776	regulation of translation
B5D82_RS16875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B5D82_RS16880	COG0284	orotidine-5'-phosphate decarboxylase activity
B5D82_RS16885	COG1596	polysaccharide export
B5D82_RS16885	COG1555	photosystem II stabilization
B5D82_RS16890	COG0813	purine-nucleoside phosphorylase activity
B5D82_RS16895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B5D82_RS16900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5D82_RS16915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5D82_RS16920	COG0537	adenosine 5'-monophosphoramidase activity
B5D82_RS16925	COG4774	siderophore transport
B5D82_RS16925	COG1629	transport
B5D82_RS16935	COG3201	nicotinamide mononucleotide transporter
B5D82_RS16945	COG3275	phosphorelay sensor kinase activity
B5D82_RS16950	COG3279	Response regulator of the LytR AlgR family
B5D82_RS16975	COG2130	NADP-dependent
B5D82_RS16985	COG0583	DNA-binding transcription factor activity
B5D82_RS16990	COG0205	6-phosphofructokinase activity
B5D82_RS17005	COG1737	Transcriptional regulator
B5D82_RS17010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5D82_RS17015	COG0363	glucosamine-6-phosphate deaminase activity
B5D82_RS17020	COG0129	dihydroxy-acid dehydratase activity
B5D82_RS17030	COG0800	Aldolase
B5D82_RS17045	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B5D82_RS17080	COG0670	Belongs to the BI1 family
B5D82_RS17085	COG0519	Catalyzes the synthesis of GMP from XMP
B5D82_RS17105	COG2169	Transcriptional regulator
B5D82_RS17165	COG0513	Belongs to the DEAD box helicase family
B5D82_RS17170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5D82_RS17175	COG3257	ureidoglycine aminohydrolase activity
B5D82_RS17185	COG1953	Uracil, thiamine, allantoin
B5D82_RS17190	COG0281	malic enzyme
B5D82_RS17195	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B5D82_RS17250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5D82_RS17280	COG0745	RESPONSE REGULATOR receiver
B5D82_RS17295	COG1966	Carbon starvation protein
B5D82_RS17300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5D82_RS17305	COG2866	Carboxypeptidase
B5D82_RS17310	COG1115	amino acid carrier protein
B5D82_RS17320	COG3139	Protein of unknown function (DUF1315)
B5D82_RS17330	COG0252	asparaginase activity
B5D82_RS17335	COG0616	signal peptide processing
B5D82_RS17340	COG0778	Nitroreductase
B5D82_RS17345	COG0017	Asparaginyl-tRNA synthetase
B5D82_RS17355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5D82_RS17360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5D82_RS17365	COG0156	8-amino-7-oxononanoate synthase activity
B5D82_RS17370	COG1073	alpha beta
B5D82_RS17370	COG2226	methyltransferase
B5D82_RS17375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B5D82_RS17390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5D82_RS17430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B5D82_RS17435	COG0625	glutathione transferase activity
B5D82_RS17440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B5D82_RS17445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B5D82_RS17450	COG0589	response to stress
B5D82_RS17455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5D82_RS17475	COG0330	HflC and HflK could
B5D82_RS17500	COG0598	Magnesium transport protein CorA
B5D82_RS17525	COG3021	interspecies interaction between organisms
B5D82_RS17570	COG2853	Lipoprotein
B5D82_RS17575	COG1770	oligopeptidase
B5D82_RS17585	COG0646	methionine synthase
B5D82_RS17585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B5D82_RS17620	COG0653	protein targeting
B5D82_RS17625	COG2223	nitrite transmembrane transporter activity
B5D82_RS17645	COG3383	formate dehydrogenase (NAD+) activity
B5D82_RS17650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B5D82_RS17665	COG2133	pyrroloquinoline quinone binding
B5D82_RS17675	COG1335	isochorismatase
B5D82_RS17685	COG3038	cytochrome b561
B5D82_RS17695	COG0582	viral genome integration into host DNA
B5D82_RS17780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5D82_RS17835	COG0501	Belongs to the peptidase M48B family
B5D82_RS17855	COG0534	Mate efflux family protein
B5D82_RS17875	COG0390	transport system, permease component
B5D82_RS17890	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS17895	COG0778	Nitroreductase
B5D82_RS17900	COG2201	protein-glutamate methylesterase activity
B5D82_RS17915	COG0542	response to heat
B5D82_RS17920	COG2130	NADP-dependent
B5D82_RS17925	COG0318	PFAM AMP-dependent synthetase and ligase
B5D82_RS17930	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS17935	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS17955	COG1028	Short-chain dehydrogenase reductase Sdr
B5D82_RS17985	COG0418	dihydroorotase activity
B5D82_RS17990	COG3081	Nucleoid-associated protein
B5D82_RS17995	COG3082	Protein of unknown function (DUF1414)
B5D82_RS18020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5D82_RS18025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B5D82_RS18030	COG2894	cell division
B5D82_RS18050	COG0659	secondary active sulfate transmembrane transporter activity
B5D82_RS18070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B5D82_RS18075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5D82_RS18080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B5D82_RS18085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B5D82_RS18090	COG0531	amino acid
B5D82_RS18090	COG1674	ftsk spoiiie
B5D82_RS18100	COG0686	Belongs to the AlaDH PNT family
B5D82_RS18105	COG0492	ferredoxin-NADP+ reductase activity
B5D82_RS18120	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B5D82_RS18125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B5D82_RS18130	COG0542	response to heat
B5D82_RS18135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B5D82_RS18140	COG1278	Cold shock
B5D82_RS18165	COG0482	sulfurtransferase activity
B5D82_RS18170	COG2915	High frequency lysogenization protein hflD homolog
B5D82_RS18175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5D82_RS18180	COG2850	peptidyl-arginine hydroxylation
B5D82_RS18200	COG0247	lactate metabolic process
B5D82_RS18200	COG0277	FAD linked oxidase domain protein
B5D82_RS18205	COG0574	Belongs to the PEP-utilizing enzyme family
B5D82_RS18205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5D82_RS18210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B5D82_RS18215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5D82_RS18230	COG0572	uridine kinase
B5D82_RS18235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5D82_RS18240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B5D82_RS18245	COG1435	thymidine kinase activity
B5D82_RS18255	COG0295	cytidine deaminase activity
B5D82_RS18265	COG1309	transcriptional regulator
B5D82_RS18275	COG1785	Belongs to the alkaline phosphatase family
B5D82_RS18280	COG0626	cystathionine gamma-synthase activity
B5D82_RS18285	COG0417	DNA replication proofreading
B5D82_RS18290	COG1199	ATP-dependent helicase activity
B5D82_RS18305	COG0745	RESPONSE REGULATOR receiver
B5D82_RS18310	COG2205	protein histidine kinase activity
B5D82_RS18320	COG0602	queuosine metabolic process
B5D82_RS18325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B5D82_RS18330	COG0527	aspartate kinase activity
B5D82_RS18340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B5D82_RS18345	COG2226	methyltransferase
B5D82_RS18355	COG1388	LysM domain
B5D82_RS18355	COG0741	lytic transglycosylase activity
B5D82_RS18365	COG0367	asparagine synthase
B5D82_RS18375	COG0167	dihydroorotate dehydrogenase activity
B5D82_RS18380	COG2902	Dehydrogenase
B5D82_RS18410	COG0308	aminopeptidase N
B5D82_RS18415	COG1757	Na H antiporter
B5D82_RS18425	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B5D82_RS18435	COG1956	GAF domain-containing protein
B5D82_RS18440	COG3791	Glutathione-dependent formaldehyde-activating
B5D82_RS18450	COG2234	aminopeptidase activity
B5D82_RS18460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B5D82_RS18465	COG0372	Belongs to the citrate synthase family
B5D82_RS18470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B5D82_RS18480	COG2715	membrane protein required for spore maturation
B5D82_RS18485	COG0084	hydrolase, TatD family'
B5D82_RS18500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5D82_RS18505	COG3706	GGDEF domain
B5D82_RS18505	COG4251	negative regulation of phosphorylation
B5D82_RS18505	COG5001	Diguanylate cyclase
B5D82_RS18505	COG2203	Gaf domain
B5D82_RS18515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B5D82_RS18520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5D82_RS18525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5D82_RS18530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5D82_RS18540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B5D82_RS18545	COG0416	fatty acid biosynthetic process
B5D82_RS18550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B5D82_RS18555	COG1399	metal-binding, possibly nucleic acid-binding protein
B5D82_RS18580	COG1530	ribonuclease E activity
B5D82_RS18585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5D82_RS18595	COG4251	negative regulation of phosphorylation
B5D82_RS18595	COG3706	GGDEF domain
B5D82_RS18595	COG2203	Gaf domain
B5D82_RS18595	COG5001	Diguanylate cyclase
B5D82_RS18670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B5D82_RS18675	COG0322	excinuclease ABC activity
B5D82_RS18680	COG2197	response regulator
B5D82_RS18690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5D82_RS18695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5D82_RS18720	COG2501	S4 domain
B5D82_RS18730	COG0442	prolyl-tRNA aminoacylation
B5D82_RS18740	COG0436	Aminotransferase
B5D82_RS18745	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B5D82_RS18750	COG2995	paraquat-inducible protein a
B5D82_RS18770	COG1230	cation diffusion facilitator family transporter
B5D82_RS18775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5D82_RS18785	COG2252	PERMEase
B5D82_RS18800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5D82_RS18805	COG3616	Alanine racemase, N-terminal domain
B5D82_RS18810	COG2423	ornithine cyclodeaminase activity
B5D82_RS18815	COG1309	transcriptional regulator
B5D82_RS18825	COG0402	S-adenosylhomocysteine deaminase activity
B5D82_RS18850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5D82_RS18865	COG3257	ureidoglycine aminohydrolase activity
B5D82_RS18870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5D82_RS18875	COG2351	hydroxyisourate hydrolase activity
B5D82_RS18885	COG0589	response to stress
B5D82_RS18915	COG1309	transcriptional regulator
B5D82_RS18920	COG1802	Transcriptional regulator
B5D82_RS18925	COG0281	malic enzyme
B5D82_RS18930	COG5507	3-demethylubiquinone-9 3-methyltransferase
B5D82_RS18940	COG3781	membrane
B5D82_RS18945	COG2918	glutathione biosynthetic process
B5D82_RS18965	COG0583	DNA-binding transcription factor activity
B5D82_RS18975	COG1252	NADH dehydrogenase
B5D82_RS19005	COG0583	DNA-binding transcription factor activity
B5D82_RS19010	COG0189	ligase activity
B5D82_RS19020	COG0189	ligase activity
B5D82_RS19020	COG4067	protein conserved in archaea
B5D82_RS19025	COG3264	Mechanosensitive ion channel
B5D82_RS19025	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B5D82_RS19040	COG4251	negative regulation of phosphorylation
B5D82_RS19045	COG0643	Histidine kinase
B5D82_RS19045	COG0784	Response regulator, receiver
B5D82_RS19045	COG2198	Histidine kinase
B5D82_RS19050	COG5001	Diguanylate cyclase
B5D82_RS19050	COG3300	MHYT domain
B5D82_RS19100	COG0729	surface antigen
B5D82_RS19110	COG0598	Magnesium transport protein CorA
B5D82_RS19115	COG2239	Acts as a magnesium transporter
B5D82_RS19125	COG0589	response to stress
B5D82_RS19145	COG0006	proline dipeptidase activity
B5D82_RS19155	COG2350	Protein conserved in bacteria
B5D82_RS19205	COG2205	protein histidine kinase activity
B5D82_RS19210	COG0745	RESPONSE REGULATOR receiver
B5D82_RS19220	COG0708	Exodeoxyribonuclease III
B5D82_RS19225	COG2226	methyltransferase
B5D82_RS19230	COG3092	negative regulation of chromosome organization
B5D82_RS19240	COG1393	Belongs to the ArsC family
B5D82_RS19245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5D82_RS19280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5D82_RS19285	COG1648	precorrin-2 dehydrogenase activity
B5D82_RS19285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5D82_RS19305	COG4783	chaperone-mediated protein folding
B5D82_RS19310	COG1393	Belongs to the ArsC family
B5D82_RS19335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5D82_RS19340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B5D82_RS19350	COG0121	glutamine amidotransferase
B5D82_RS19355	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS19360	COG0667	Aldo Keto reductase
B5D82_RS19370	COG1960	acyl-CoA dehydrogenase activity
B5D82_RS19375	COG2165	general secretion pathway protein
B5D82_RS19380	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B5D82_RS19390	COG2873	o-acetylhomoserine
B5D82_RS19405	COG1823	symporter activity
B5D82_RS19410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5D82_RS19410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5D82_RS19565	COG3093	addiction module antidote protein HigA
B5D82_RS19665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5D82_RS19705	COG0405	Gamma-glutamyltransferase
B5D82_RS19715	COG3706	GGDEF domain
B5D82_RS19725	COG0069	glutamate synthase activity
B5D82_RS19735	COG1032	radical SAM domain protein