locus-tag	class	description
H3L98_RS00090	COG1475	DNA binding
H3L98_RS00110	COG1012	belongs to the aldehyde dehydrogenase family
H3L98_RS00115	COG1454	alcohol dehydrogenase
H3L98_RS00120	COG3485	protocatechuate 3,4-dioxygenase
H3L98_RS00130	COG0583	DNA-binding transcription factor activity
H3L98_RS00135	COG0183	Belongs to the thiolase family
H3L98_RS00140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H3L98_RS00145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H3L98_RS00160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H3L98_RS00180	COG1484	DNA-dependent DNA replication
H3L98_RS00185	COG4584	PFAM Integrase catalytic
H3L98_RS00195	COG2831	hemolysin activation secretion protein
H3L98_RS00200	COG3210	domain, Protein
H3L98_RS00200	COG3210	domain, Protein
H3L98_RS00245	COG3210	domain, Protein
H3L98_RS00250	COG2831	hemolysin activation secretion protein
H3L98_RS00260	COG0433	COG0433 Predicted ATPase
H3L98_RS00310	COG2304	oxidoreductase activity
H3L98_RS00325	COG2273	Hydrolase Family 16
H3L98_RS00325	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H3L98_RS00350	COG1127	ABC transporter
H3L98_RS00355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H3L98_RS00360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H3L98_RS00385	COG0824	Thioesterase
H3L98_RS00440	COG1183	phosphatidylcholine synthase activity
H3L98_RS00445	COG1742	UPF0060 membrane protein
H3L98_RS00455	COG0494	nUDIX hydrolase
H3L98_RS00480	COG2259	Doxx family
H3L98_RS00485	COG0583	DNA-binding transcription factor activity
H3L98_RS00505	COG1595	DNA-templated transcription, initiation
H3L98_RS00530	COG2259	Doxx family
H3L98_RS00540	COG1115	amino acid carrier protein
H3L98_RS00565	COG1278	Cold shock
H3L98_RS00585	COG2304	oxidoreductase activity
H3L98_RS00610	COG0277	FAD linked oxidase domain protein
H3L98_RS00615	COG1739	Uncharacterized protein family UPF0029
H3L98_RS00655	COG0730	response to heat
H3L98_RS00735	COG2823	Periplasmic or secreted lipoprotein
H3L98_RS00740	COG0765	amino acid transport
H3L98_RS00745	COG0800	Aldolase
H3L98_RS00760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H3L98_RS00765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3L98_RS00775	COG3335	DDE superfamily endonuclease
H3L98_RS00840	COG1234	tRNA 3'-trailer cleavage
H3L98_RS00855	COG2354	Protein conserved in bacteria
H3L98_RS00860	COG0196	riboflavin kinase activity
H3L98_RS00865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3L98_RS00880	COG2855	membrane
H3L98_RS00885	COG0805	protein transport
H3L98_RS00895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H3L98_RS00915	COG2851	Citrate transporter
H3L98_RS00935	COG0582	viral genome integration into host DNA
H3L98_RS00945	COG3023	N-Acetylmuramoyl-L-alanine amidase
H3L98_RS00965	COG0330	HflC and HflK could
H3L98_RS00980	COG1643	Atp-dependent helicase
H3L98_RS01035	COG0583	DNA-binding transcription factor activity
H3L98_RS01040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3L98_RS01070	COG1333	cytochrome c biogenesis protein
H3L98_RS01075	COG2364	Membrane
H3L98_RS01080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H3L98_RS01110	COG0494	nUDIX hydrolase
H3L98_RS01125	COG1652	LysM domain
H3L98_RS01135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3L98_RS01145	COG4608	Belongs to the ABC transporter superfamily
H3L98_RS01165	COG1760	l-serine dehydratase
H3L98_RS01170	COG0303	'Molybdopterin
H3L98_RS01175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H3L98_RS01180	COG0521	Mo-molybdopterin cofactor biosynthetic process
H3L98_RS01185	COG0746	molybdenum cofactor guanylyltransferase activity
H3L98_RS01190	COG0315	cyclic pyranopterin monophosphate synthase activity
H3L98_RS01195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H3L98_RS01200	COG0314	molybdopterin synthase activity
H3L98_RS01205	COG3850	Histidine kinase
H3L98_RS01210	COG2197	response regulator
H3L98_RS01215	COG3842	ATPase activity
H3L98_RS01220	COG4149	molybdate abc transporter
H3L98_RS01225	COG0725	ABC transporter, periplasmic molybdate-binding protein
H3L98_RS01230	COG2223	nitrite transmembrane transporter activity
H3L98_RS01240	COG1741	Belongs to the pirin family
H3L98_RS01250	COG2181	nitrate reductase activity
H3L98_RS01255	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H3L98_RS01260	COG1140	nitrate reductase beta subunit
H3L98_RS01265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H3L98_RS01315	COG0799	negative regulation of ribosome biogenesis
H3L98_RS01335	COG2070	2-Nitropropane dioxygenase
H3L98_RS01345	COG2056	Na+-H+ antiporter family
H3L98_RS01360	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H3L98_RS01390	COG2878	Part of a membrane complex involved in electron transport
H3L98_RS01400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H3L98_RS01400	COG0616	signal peptide processing
H3L98_RS01405	COG0633	Ferredoxin
H3L98_RS01440	COG0642	Histidine kinase
H3L98_RS01455	COG0758	DNA mediated transformation
H3L98_RS01455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3L98_RS01465	COG1490	D-aminoacyl-tRNA deacylase activity
H3L98_RS01470	COG3304	Inner membrane component domain
H3L98_RS01480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H3L98_RS01500	COG0308	aminopeptidase N
H3L98_RS01585	COG0500	methyltransferase
H3L98_RS01690	COG3842	ATPase activity
H3L98_RS01735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H3L98_RS01750	COG0200	Binds to the 23S rRNA
H3L98_RS01880	COG0733	neurotransmitter:sodium symporter activity
H3L98_RS01920	COG2884	Cell division ATP-binding protein ftsE
H3L98_RS01930	COG1476	TRANSCRIPTIONal
H3L98_RS01955	COG0697	spore germination
H3L98_RS02030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H3L98_RS02060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H3L98_RS02075	COG2252	PERMEase
H3L98_RS02125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H3L98_RS02145	COG1132	(ABC) transporter
H3L98_RS02160	COG1012	belongs to the aldehyde dehydrogenase family
H3L98_RS02170	COG0778	Nitroreductase
H3L98_RS02195	COG1690	Belongs to the RtcB family
H3L98_RS02200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H3L98_RS02230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H3L98_RS02260	COG2070	2-Nitropropane dioxygenase
H3L98_RS02280	COG1399	metal-binding, possibly nucleic acid-binding protein
H3L98_RS02310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H3L98_RS02320	COG2086	electron transfer activity
H3L98_RS02355	COG0513	Belongs to the DEAD box helicase family
H3L98_RS02395	COG0628	permease
H3L98_RS02425	COG0339	signal peptide processing
H3L98_RS02460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H3L98_RS02470	COG4224	UPF0291 protein
H3L98_RS02475	COG1733	regulation of RNA biosynthetic process
H3L98_RS02480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3L98_RS02490	COG2962	Rard protein
H3L98_RS02495	COG1522	sequence-specific DNA binding
H3L98_RS02520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H3L98_RS02540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L98_RS02555	COG0142	geranyltranstransferase activity
H3L98_RS02565	COG2217	Heavy metal translocating P-type atpase
H3L98_RS02590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H3L98_RS02595	COG1335	isochorismatase
H3L98_RS02630	COG0300	oxidoreductase activity
H3L98_RS02645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H3L98_RS02690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H3L98_RS02715	COG1484	DNA-dependent DNA replication
H3L98_RS02720	COG4584	PFAM Integrase catalytic
H3L98_RS02730	COG3676	manually curated
H3L98_RS02740	COG2217	Heavy metal translocating P-type atpase
H3L98_RS02750	COG0789	Transcriptional regulator
H3L98_RS02765	COG0789	Transcriptional regulator
H3L98_RS02770	COG0798	PFAM Bile acid sodium symporter
H3L98_RS02775	COG0798	PFAM Bile acid sodium symporter
H3L98_RS02830	COG1272	protein, Hemolysin III
H3L98_RS02845	COG1177	transmembrane transport
H3L98_RS02850	COG1176	ABC-type spermidine putrescine transport system, permease component I
H3L98_RS02855	COG3842	ATPase activity
H3L98_RS02880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H3L98_RS02900	COG2824	Alkylphosphonate utilization operon protein PhnA
H3L98_RS02910	COG0860	N-Acetylmuramoyl-L-alanine amidase
H3L98_RS02910	COG2247	cell wall binding repeat
H3L98_RS02930	COG2755	lipolytic protein G-D-S-L family
H3L98_RS02935	COG0514	ATP-dependent DNA helicase (RecQ)
H3L98_RS02985	COG1454	alcohol dehydrogenase
H3L98_RS03010	COG4589	Belongs to the CDS family
H3L98_RS03020	COG0523	cobalamin synthesis protein
H3L98_RS03025	COG0557	exoribonuclease II activity
H3L98_RS03050	COG0753	catalase activity
H3L98_RS03120	COG0142	geranyltranstransferase activity
H3L98_RS03140	COG0859	PFAM glycosyl transferase family 9
H3L98_RS03140	COG0457	Tetratricopeptide repeat
H3L98_RS03145	COG0859	PFAM glycosyl transferase family 9
H3L98_RS03150	COG0742	ribosomal rna small subunit methyltransferase
H3L98_RS03155	COG1408	metallophosphoesterase
H3L98_RS03165	COG2226	methyltransferase
H3L98_RS03255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H3L98_RS03285	COG0561	phosphatase activity
H3L98_RS03290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L98_RS03320	COG0791	NLP P60 protein
H3L98_RS03325	COG0512	Glutamine amidotransferase of anthranilate synthase
H3L98_RS03330	COG1525	nuclease
H3L98_RS03355	COG4221	oxidoreductase activity
H3L98_RS03365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H3L98_RS03390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H3L98_RS03410	COG0471	metal ion transport
H3L98_RS03435	COG1999	signal sequence binding
H3L98_RS03460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3L98_RS03485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H3L98_RS03505	COG0195	Participates in both transcription termination and antitermination
H3L98_RS03535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H3L98_RS03570	COG2831	hemolysin activation secretion protein
H3L98_RS03575	COG3210	domain, Protein
H3L98_RS03575	COG3210	domain, Protein
H3L98_RS03650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3L98_RS03660	COG2951	lytic endotransglycosylase activity
H3L98_RS03690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H3L98_RS03720	COG0582	viral genome integration into host DNA
H3L98_RS03780	COG3263	regulation of cellular component size
H3L98_RS03800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3L98_RS03805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3L98_RS03820	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H3L98_RS03830	COG1280	lysine exporter protein (LysE YggA)
H3L98_RS03845	COG1034	ATP synthesis coupled electron transport
H3L98_RS03910	COG0732	type I restriction modification DNA specificity domain
H3L98_RS03930	COG0009	L-threonylcarbamoyladenylate synthase
H3L98_RS03945	COG0601	transmembrane transport
H3L98_RS03955	COG3045	CreA protein
H3L98_RS03965	COG0140	phosphoribosyl-ATP diphosphatase activity
H3L98_RS03995	COG2841	Protein conserved in bacteria
H3L98_RS04000	COG0617	tRNA 3'-terminal CCA addition
H3L98_RS04020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H3L98_RS04020	COG3264	Mechanosensitive ion channel
H3L98_RS04040	COG0307	riboflavin synthase, alpha
H3L98_RS04055	COG1253	flavin adenine dinucleotide binding
H3L98_RS04065	COG0288	reversible hydration of carbon dioxide
H3L98_RS04250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H3L98_RS04255	COG1115	amino acid carrier protein
H3L98_RS04270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3L98_RS04295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H3L98_RS04330	COG0251	oxidation-reduction process
H3L98_RS04355	COG1765	OsmC-like protein
H3L98_RS04360	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H3L98_RS04365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H3L98_RS04390	COG1214	PFAM Peptidase M22, glycoprotease
H3L98_RS04410	COG2999	glutathione oxidoreductase activity
H3L98_RS04430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3L98_RS04450	COG1162	GTPase activity
H3L98_RS04460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3L98_RS04545	COG3945	hemerythrin HHE cation binding domain
H3L98_RS04560	COG1047	Peptidyl-prolyl cis-trans
H3L98_RS04600	COG1966	Carbon starvation protein
H3L98_RS04640	COG1555	photosystem II stabilization
H3L98_RS04640	COG1596	polysaccharide export
H3L98_RS04690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3L98_RS04695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3L98_RS04725	COG0024	Methionine aminopeptidase
H3L98_RS04790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3L98_RS04810	COG0671	phosphoesterase, PA-phosphatase related
H3L98_RS04820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3L98_RS04850	COG0210	DNA helicase
H3L98_RS04870	COG0012	GTP binding
H3L98_RS04875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L98_RS04885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H3L98_RS04910	COG0612	Peptidase, M16
H3L98_RS04920	COG0312	modulator of DNA gyrase
H3L98_RS04950	COG2949	membrane
H3L98_RS04955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H3L98_RS04965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L98_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
H3L98_RS04980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3L98_RS04995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H3L98_RS05000	COG1238	metal cluster binding
H3L98_RS05035	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
H3L98_RS05055	COG3217	Mosc domain protein beta barrel domain protein
H3L98_RS05055	COG0633	Ferredoxin
H3L98_RS05100	COG1132	(ABC) transporter
H3L98_RS05115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H3L98_RS05135	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H3L98_RS05160	COG1393	Belongs to the ArsC family
H3L98_RS05180	COG1794	racemase activity, acting on amino acids and derivatives
H3L98_RS05190	COG0583	DNA-binding transcription factor activity
H3L98_RS05200	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H3L98_RS05250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H3L98_RS05275	COG1442	glycosyl transferase family 8
H3L98_RS05315	COG1247	-acetyltransferase
H3L98_RS05330	COG2268	Band 7 protein
H3L98_RS05335	COG4783	chaperone-mediated protein folding
H3L98_RS05340	COG0393	Putative heavy-metal-binding
H3L98_RS05345	COG0393	Putative heavy-metal-binding
H3L98_RS05355	COG1086	Polysaccharide biosynthesis protein
H3L98_RS05370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H3L98_RS05380	COG1083	cytidylyl-transferase
H3L98_RS05390	COG2089	acid synthase
H3L98_RS05395	COG2244	polysaccharide biosynthetic process
H3L98_RS05410	COG1216	Glycosyl transferase, family 2
H3L98_RS05415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3L98_RS05420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H3L98_RS05425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H3L98_RS05435	COG0438	transferase activity, transferring glycosyl groups
H3L98_RS05445	COG0438	transferase activity, transferring glycosyl groups
H3L98_RS05455	COG1063	alcohol dehydrogenase
H3L98_RS05470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3L98_RS05480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H3L98_RS05495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H3L98_RS05500	COG0544	peptidyl-prolyl cis-trans isomerase activity
H3L98_RS05540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H3L98_RS05590	COG0681	Belongs to the peptidase S26 family
H3L98_RS05600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3L98_RS05635	COG0613	PHP domain protein
H3L98_RS05650	COG2857	Cytochrome c1
H3L98_RS05655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H3L98_RS05660	COG0723	plastoquinol--plastocyanin reductase activity
H3L98_RS05680	COG1530	ribonuclease E activity
H3L98_RS05695	COG0560	Phosphoserine phosphatase
H3L98_RS05700	COG1396	sequence-specific DNA binding
H3L98_RS05715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H3L98_RS05725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H3L98_RS05730	COG1561	YicC-like family, N-terminal region
H3L98_RS05745	COG0511	ligase activity, forming carbon-carbon bonds
H3L98_RS05780	COG0501	Belongs to the peptidase M48B family
H3L98_RS05790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H3L98_RS05790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H3L98_RS05855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H3L98_RS05910	COG3977	Valine--pyruvate aminotransferase
H3L98_RS05925	COG0514	ATP-dependent DNA helicase (RecQ)
H3L98_RS05930	COG1045	serine acetyltransferase
H3L98_RS05985	COG1388	LysM domain
H3L98_RS05985	COG0741	lytic transglycosylase activity
H3L98_RS06020	COG0488	(ABC) transporter
H3L98_RS06080	COG0538	isocitrate dehydrogenase activity
H3L98_RS06095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H3L98_RS06100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3L98_RS06100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H3L98_RS06150	COG0268	Binds directly to 16S ribosomal RNA
H3L98_RS06190	COG2201	protein-glutamate methylesterase activity
H3L98_RS06205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3L98_RS06205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3L98_RS06210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H3L98_RS06215	COG1854	S-ribosylhomocysteine lyase activity
H3L98_RS06220	COG0583	DNA-binding transcription factor activity
H3L98_RS06230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3L98_RS06240	COG0586	Pfam SNARE associated Golgi protein
H3L98_RS06255	COG0351	phosphomethylpyrimidine kinase
H3L98_RS06265	COG0494	nUDIX hydrolase
H3L98_RS06270	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H3L98_RS06275	COG3094	Invasion gene expression up-regulator, SirB
H3L98_RS06285	COG0739	heme binding
H3L98_RS06290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H3L98_RS06300	COG1137	ATPase activity
H3L98_RS06315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H3L98_RS06325	COG1620	l-lactate permease
H3L98_RS06330	COG1063	alcohol dehydrogenase
H3L98_RS06360	COG0305	Participates in initiation and elongation during chromosome replication
H3L98_RS06365	COG0756	dUTP diphosphatase activity
H3L98_RS06380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H3L98_RS06405	COG1192	Involved in chromosome partitioning
H3L98_RS06410	COG0737	Belongs to the 5'-nucleotidase family
H3L98_RS06415	COG0488	(ABC) transporter
H3L98_RS06425	COG0814	amino acid
H3L98_RS06430	COG2211	Major facilitator Superfamily
H3L98_RS06435	COG0708	Exodeoxyribonuclease III
H3L98_RS06455	COG0135	phosphoribosylanthranilate isomerase activity
H3L98_RS06495	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3L98_RS06505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H3L98_RS06510	COG0584	glycerophosphoryl diester phosphodiesterase
H3L98_RS06515	COG2271	Major facilitator Superfamily
H3L98_RS06530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3L98_RS06560	COG2837	iron assimilation
H3L98_RS06575	COG0084	hydrolase, TatD family'
H3L98_RS06605	COG0347	Belongs to the P(II) protein family
H3L98_RS06615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H3L98_RS06670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H3L98_RS06675	COG0515	serine threonine protein kinase
H3L98_RS06675	COG3266	domain, Protein
H3L98_RS06705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3L98_RS06715	COG0531	amino acid
H3L98_RS06720	COG1982	Orn Lys Arg decarboxylase major
H3L98_RS06730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H3L98_RS06745	COG0356	it plays a direct role in the translocation of protons across the membrane
H3L98_RS06820	COG1466	dna polymerase III delta subunit
H3L98_RS06835	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H3L98_RS06840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H3L98_RS06850	COG0440	acetolactate synthase activity
H3L98_RS06855	COG0028	Belongs to the TPP enzyme family
H3L98_RS06890	COG2814	Major facilitator Superfamily
H3L98_RS06900	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H3L98_RS06910	COG0431	NADPH-dependent FMN reductase
H3L98_RS06920	COG0625	glutathione transferase activity
H3L98_RS06935	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
H3L98_RS06940	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H3L98_RS06955	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H3L98_RS06955	COG0037	tRNA processing
H3L98_RS06985	COG4650	regulator
H3L98_RS07005	COG1297	OPT oligopeptide transporter protein
H3L98_RS07015	COG1702	phosphate starvation-inducible protein PhoH
H3L98_RS07025	COG0084	hydrolase, TatD family'
H3L98_RS07045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H3L98_RS07050	COG4245	von Willebrand factor, type A
H3L98_RS07065	COG1074	ATP-dependent DNA helicase activity
H3L98_RS07080	COG0039	L-malate dehydrogenase activity
H3L98_RS07090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3L98_RS07095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3L98_RS07100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H3L98_RS07145	COG1607	acyl-coa hydrolase
H3L98_RS07150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H3L98_RS07185	COG0210	DNA helicase
H3L98_RS07250	COG1114	Component of the transport system for branched-chain amino acids
H3L98_RS07270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3L98_RS07275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3L98_RS07280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H3L98_RS07290	COG2995	paraquat-inducible protein a
H3L98_RS07300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H3L98_RS07300	COG3008	intermembrane lipid transfer
H3L98_RS07315	COG0513	Belongs to the DEAD box helicase family
H3L98_RS07320	COG2975	iron-sulfur cluster assembly
H3L98_RS07340	COG1914	H( )-stimulated, divalent metal cation uptake system
H3L98_RS07360	COG1289	transmembrane transporter activity
H3L98_RS07375	COG0697	spore germination
H3L98_RS07380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3L98_RS07385	COG0318	PFAM AMP-dependent synthetase and ligase
H3L98_RS07415	COG0372	Belongs to the citrate synthase family
H3L98_RS07460	COG0277	FAD linked oxidase domain protein
H3L98_RS07465	COG1560	Kdo2-lipid A biosynthetic process
H3L98_RS07495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H3L98_RS07495	COG3453	Protein conserved in bacteria
H3L98_RS07505	COG0494	nUDIX hydrolase
H3L98_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
H3L98_RS07520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H3L98_RS07525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H3L98_RS07535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3L98_RS07540	COG2095	MarC family integral membrane protein
H3L98_RS07545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H3L98_RS07550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H3L98_RS07585	COG1073	alpha beta
H3L98_RS07605	COG0857	belongs to the CobB CobQ family
H3L98_RS07605	COG0280	phosphate acetyltransferase
H3L98_RS07625	COG0625	glutathione transferase activity
H3L98_RS07675	COG0121	glutamine amidotransferase
H3L98_RS07680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H3L98_RS07685	COG1984	allophanate hydrolase subunit 2
H3L98_RS07690	COG2828	Protein conserved in bacteria
H3L98_RS07705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H3L98_RS07710	COG0489	protein tyrosine kinase activity
H3L98_RS07715	COG2321	neutral zinc metallopeptidase
H3L98_RS07720	COG1049	propionate catabolic process, 2-methylcitrate cycle
H3L98_RS07730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H3L98_RS07740	COG0285	dihydrofolate synthase activity
H3L98_RS07760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H3L98_RS07765	COG1388	LysM domain
H3L98_RS07765	COG4942	peptidase
H3L98_RS07770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H3L98_RS07775	COG0271	Belongs to the BolA IbaG family
H3L98_RS07785	COG0745	RESPONSE REGULATOR receiver
H3L98_RS07805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H3L98_RS07820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3L98_RS07825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H3L98_RS07870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H3L98_RS07880	COG2076	Multidrug Resistance protein
H3L98_RS07890	COG1546	Belongs to the CinA family
H3L98_RS07930	COG0004	ammonium transporteR
H3L98_RS07950	COG0840	transmembrane signaling receptor activity
H3L98_RS07975	COG0813	purine-nucleoside phosphorylase activity
H3L98_RS08000	COG2867	negative regulation of translational initiation
H3L98_RS08005	COG2914	Belongs to the UPF0125 (RnfH) family
H3L98_RS08015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H3L98_RS08045	COG0714	Associated with various cellular activities
H3L98_RS08055	COG0786	glutamate:sodium symporter activity
H3L98_RS08075	COG0252	asparaginase activity
H3L98_RS08090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3L98_RS08095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H3L98_RS08100	COG1619	proteins homologs of microcin C7 resistance protein MccF
H3L98_RS08115	COG1686	Belongs to the peptidase S11 family
H3L98_RS08120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H3L98_RS08125	COG0105	UTP biosynthetic process
H3L98_RS08130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L98_RS08160	COG2205	protein histidine kinase activity
H3L98_RS08180	COG3307	-O-antigen
H3L98_RS08185	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3L98_RS08190	COG0567	Dehydrogenase, E1 component
H3L98_RS08200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H3L98_RS08205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H3L98_RS08210	COG1053	succinate dehydrogenase
H3L98_RS08220	COG2009	succinate dehydrogenase
H3L98_RS08225	COG1448	Aminotransferase
H3L98_RS08230	COG0488	(ABC) transporter
H3L98_RS08245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H3L98_RS08290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H3L98_RS08295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H3L98_RS08300	COG1530	ribonuclease E activity
H3L98_RS08305	COG0436	Aminotransferase
H3L98_RS08310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H3L98_RS08325	COG0515	serine threonine protein kinase
H3L98_RS08335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H3L98_RS08350	COG2431	L-lysine efflux transmembrane transporter activity
H3L98_RS08380	COG1755	Isoprenylcysteine carboxyl methyltransferase
H3L98_RS08395	COG0477	Major facilitator Superfamily
H3L98_RS08415	COG1686	Belongs to the peptidase S11 family
H3L98_RS08430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3L98_RS08435	COG0300	oxidoreductase activity
H3L98_RS08440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H3L98_RS08445	COG1562	ergosterol biosynthetic process
H3L98_RS08455	COG0802	atpase or kinase
H3L98_RS08530	COG1304	FMN binding
H3L98_RS08565	COG0557	exoribonuclease II activity
H3L98_RS08570	COG2866	Carboxypeptidase
H3L98_RS08605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H3L98_RS08625	COG0772	Belongs to the SEDS family
H3L98_RS08630	COG0768	penicillin binding
H3L98_RS08645	COG1077	Cell shape determining protein MreB Mrl
H3L98_RS08665	COG2201	protein-glutamate methylesterase activity
H3L98_RS08685	COG1129	ABC transporter
H3L98_RS08695	COG1085	galactose-1-phosphate uridylyltransferase
H3L98_RS08700	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H3L98_RS08725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3L98_RS08740	COG2010	Cytochrome c
H3L98_RS08755	COG3278	Belongs to the heme-copper respiratory oxidase family
H3L98_RS08795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H3L98_RS08805	COG2350	Protein conserved in bacteria
H3L98_RS08820	COG3133	Outer membrane lipoprotein
H3L98_RS08840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H3L98_RS08855	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H3L98_RS08860	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H3L98_RS08870	COG2239	Acts as a magnesium transporter
H3L98_RS08895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H3L98_RS08900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H3L98_RS08900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H3L98_RS08920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3L98_RS08925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3L98_RS08930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3L98_RS08935	COG1862	Preprotein translocase
H3L98_RS08945	COG2274	protein secretion by the type I secretion system
H3L98_RS08960	COG3048	D-serine ammonia-lyase activity
H3L98_RS08980	COG0484	heat shock protein binding
H3L98_RS08985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H3L98_RS08990	COG4208	sulfate ABC transporter
H3L98_RS09005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H3L98_RS09005	COG0543	2 iron, 2 sulfur cluster binding
H3L98_RS09015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H3L98_RS09030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H3L98_RS09070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3L98_RS09075	COG0765	amino acid transport
H3L98_RS09080	COG1126	abc transporter atp-binding protein
H3L98_RS09085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H3L98_RS09095	COG1970	mechanosensitive ion channel activity
H3L98_RS09100	COG0778	Nitroreductase
H3L98_RS09140	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H3L98_RS09150	COG1088	dTDP-glucose 4,6-dehydratase activity
H3L98_RS09155	COG0497	DNA recombination
H3L98_RS09165	COG2832	Protein of unknown function (DUF454)
H3L98_RS09175	COG1187	pseudouridine synthase activity
H3L98_RS09180	COG1253	flavin adenine dinucleotide binding
H3L98_RS09200	COG1199	ATP-dependent helicase activity
H3L98_RS09205	COG0469	pyruvate kinase activity
H3L98_RS09280	COG0626	cystathionine gamma-synthase activity
H3L98_RS09330	COG0312	modulator of DNA gyrase
H3L98_RS09340	COG4942	peptidase
H3L98_RS09345	COG0316	Belongs to the HesB IscA family
H3L98_RS09350	COG0822	iron-sulfur transferase activity
H3L98_RS09370	COG0793	Belongs to the peptidase S41A family
H3L98_RS09375	COG0287	Prephenate dehydrogenase
H3L98_RS09380	COG0859	PFAM glycosyl transferase family 9
H3L98_RS09385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H3L98_RS09390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H3L98_RS09405	COG1187	pseudouridine synthase activity
H3L98_RS09435	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H3L98_RS09460	COG2885	chlorophyll binding
H3L98_RS09495	COG0643	Histidine kinase
H3L98_RS09495	COG2198	Histidine kinase
H3L98_RS09500	COG2201	protein-glutamate methylesterase activity
H3L98_RS09505	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H3L98_RS09515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H3L98_RS09530	COG2814	Major facilitator Superfamily
H3L98_RS09545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H3L98_RS09545	COG0506	proline dehydrogenase activity
H3L98_RS09545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H3L98_RS09550	COG0248	Ppx GppA phosphatase
H3L98_RS09560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H3L98_RS09580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H3L98_RS09590	COG1028	Short-chain dehydrogenase reductase Sdr
H3L98_RS09600	COG3135	benzoate transporter
H3L98_RS09620	COG0586	Pfam SNARE associated Golgi protein
H3L98_RS09655	COG1346	cytolysis
H3L98_RS09660	COG3620	sequence-specific DNA binding
H3L98_RS09670	COG0492	ferredoxin-NADP+ reductase activity
H3L98_RS09740	COG2340	Cysteine-rich secretory protein family
H3L98_RS09745	COG1196	nuclear chromosome segregation
H3L98_RS09770	COG1562	ergosterol biosynthetic process
H3L98_RS09775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H3L98_RS09790	COG5000	phosphorelay sensor kinase activity
H3L98_RS09795	COG2204	response regulator
H3L98_RS09825	COG1464	Belongs to the NlpA lipoprotein family
H3L98_RS09830	COG2011	ABC-type metal ion transport system permease component
H3L98_RS09835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H3L98_RS09850	COG0569	domain protein
H3L98_RS09855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3L98_RS09860	COG0483	inositol monophosphate 1-phosphatase activity
H3L98_RS09865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H3L98_RS09880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3L98_RS09895	COG1131	(ABC) transporter
H3L98_RS09955	COG1505	serine-type exopeptidase activity
H3L98_RS09970	COG1696	Membrane protein involved in D-alanine export
H3L98_RS10010	COG1983	PspC domain protein
H3L98_RS10030	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H3L98_RS10080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H3L98_RS10090	COG0583	DNA-binding transcription factor activity
H3L98_RS10110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3L98_RS10140	COG0259	pyridoxamine-phosphate oxidase activity
H3L98_RS10210	COG0187	DNA topoisomerase II activity
H3L98_RS10240	COG3392	D12 class N6 adenine-specific DNA methyltransferase
H3L98_RS10345	COG2369	cell adhesion
H3L98_RS10450	COG4396	Host-nuclease inhibitor protein Gam
H3L98_RS10540	COG1519	Transferase
H3L98_RS10555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H3L98_RS10595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H3L98_RS10615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H3L98_RS10690	COG1335	isochorismatase
H3L98_RS10725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H3L98_RS10730	COG0179	Fumarylacetoacetate (FAA) hydrolase
H3L98_RS10775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H3L98_RS10780	COG3878	Protein conserved in bacteria