locus-tag	class	description
I6G95_RS00015	COG3583	domain protein
I6G95_RS00020	COG0084	hydrolase, TatD family'
I6G95_RS00030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G95_RS00035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G95_RS00045	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6G95_RS00055	COG2259	Doxx family
I6G95_RS00080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G95_RS00085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G95_RS00095	COG1970	mechanosensitive ion channel activity
I6G95_RS00105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G95_RS00110	COG2205	protein histidine kinase activity
I6G95_RS00115	COG0745	RESPONSE REGULATOR receiver
I6G95_RS00125	COG0254	rRNA binding
I6G95_RS00130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G95_RS00135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G95_RS00140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G95_RS00165	COG0069	glutamate synthase activity
I6G95_RS00190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G95_RS00195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G95_RS00210	COG1476	TRANSCRIPTIONal
I6G95_RS00220	COG0189	ligase activity
I6G95_RS00230	COG4770	biotin carboxylase activity
I6G95_RS00255	COG3415	Transposase
I6G95_RS00255	COG2801	Transposase and inactivated derivatives
I6G95_RS00275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G95_RS00280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G95_RS00290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G95_RS00300	COG0656	L-ascorbic acid biosynthetic process
I6G95_RS00315	COG4152	abc transporter atp-binding protein
I6G95_RS00320	COG1668	transmembrane transport
I6G95_RS00325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G95_RS00335	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G95_RS00340	COG0372	Belongs to the citrate synthase family
I6G95_RS00360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G95_RS00365	COG2252	PERMEase
I6G95_RS00385	COG1278	Cold shock
I6G95_RS00390	COG1652	LysM domain
I6G95_RS00405	COG1061	Type III restriction enzyme res subunit
I6G95_RS00450	COG2197	response regulator
I6G95_RS00465	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
I6G95_RS00470	COG0310	cobalt ion transport
I6G95_RS00480	COG1045	serine acetyltransferase
I6G95_RS00505	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS00575	COG1271	oxidase subunit
I6G95_RS00580	COG1294	oxidase, subunit
I6G95_RS00585	COG4988	ABC transporter
I6G95_RS00590	COG1132	(ABC) transporter
I6G95_RS00610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G95_RS00630	COG0456	acetyltransferase
I6G95_RS00640	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6G95_RS00665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G95_RS00680	COG1607	acyl-coa hydrolase
I6G95_RS00695	COG0386	Belongs to the glutathione peroxidase family
I6G95_RS00705	COG0778	Nitroreductase
I6G95_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
I6G95_RS00735	COG1780	Probably involved in ribonucleotide reductase function
I6G95_RS00740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G95_RS00745	COG0431	NADPH-dependent FMN reductase
I6G95_RS00800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G95_RS00815	COG1126	abc transporter atp-binding protein
I6G95_RS00820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G95_RS00825	COG0765	amino acid transport
I6G95_RS00830	COG0765	amino acid transport
I6G95_RS00835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G95_RS00850	COG2022	thiamine diphosphate biosynthetic process
I6G95_RS00860	COG2022	thiamine diphosphate biosynthetic process
I6G95_RS00860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G95_RS00865	COG0352	thiamine-phosphate diphosphorylase activity
I6G95_RS00875	COG0569	domain protein
I6G95_RS00880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G95_RS00885	COG0133	tryptophan synthase activity
I6G95_RS00895	COG0436	Aminotransferase
I6G95_RS00910	COG0151	Belongs to the GarS family
I6G95_RS00915	COG0537	adenosine 5'-monophosphoramidase activity
I6G95_RS00940	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS00970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G95_RS00975	COG1609	Transcriptional regulator
I6G95_RS00985	COG1121	(ABC) transporter
I6G95_RS00990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G95_RS00995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G95_RS01010	COG2847	Copper chaperone PCu(A)C
I6G95_RS01015	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G95_RS01030	COG1194	a g-specific adenine glycosylase
I6G95_RS01055	COG0318	PFAM AMP-dependent synthetase and ligase
I6G95_RS01070	COG1960	acyl-CoA dehydrogenase activity
I6G95_RS01075	COG1960	acyl-CoA dehydrogenase activity
I6G95_RS01085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G95_RS01095	COG3766	membrane
I6G95_RS01120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6G95_RS01125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G95_RS01150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G95_RS01160	COG0302	gtp cyclohydrolase
I6G95_RS01165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G95_RS01175	COG0037	tRNA processing
I6G95_RS01180	COG0154	amidase activity
I6G95_RS01185	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G95_RS01190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G95_RS01205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G95_RS01210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G95_RS01215	COG2837	iron assimilation
I6G95_RS01220	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS01225	COG2326	polyphosphate kinase activity
I6G95_RS01275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G95_RS01280	COG1121	(ABC) transporter
I6G95_RS01285	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS01290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G95_RS01290	COG2111	Na H antiporter
I6G95_RS01295	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G95_RS01300	COG0651	ATP synthesis coupled electron transport
I6G95_RS01340	COG0242	peptide deformylase activity
I6G95_RS01380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G95_RS01385	COG0515	serine threonine protein kinase
I6G95_RS01395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G95_RS01400	COG0280	phosphate acetyltransferase
I6G95_RS01415	COG2895	sulfate adenylyltransferase (ATP) activity
I6G95_RS01430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G95_RS01435	COG0730	response to heat
I6G95_RS01445	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G95_RS01475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G95_RS01490	COG4129	membrane
I6G95_RS01515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G95_RS01545	COG0542	response to heat
I6G95_RS01550	COG3588	fructose-bisphosphate aldolase
I6G95_RS01555	COG0586	Pfam SNARE associated Golgi protein
I6G95_RS01560	COG2860	membrane
I6G95_RS01580	COG0789	Transcriptional regulator
I6G95_RS01585	COG0484	heat shock protein binding
I6G95_RS01590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G95_RS01595	COG0443	Heat shock 70 kDa protein
I6G95_RS01610	COG1024	Enoyl-CoA hydratase
I6G95_RS01620	COG0247	lactate metabolic process
I6G95_RS01620	COG2181	nitrate reductase activity
I6G95_RS01630	COG2197	response regulator
I6G95_RS01685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G95_RS01690	COG0717	Belongs to the dCTP deaminase family
I6G95_RS01700	COG2197	response regulator
I6G95_RS01710	COG2807	transmembrane transport
I6G95_RS01725	COG4981	capsule polysaccharide biosynthetic process
I6G95_RS01745	COG0438	transferase activity, transferring glycosyl groups
I6G95_RS01750	COG0500	methyltransferase
I6G95_RS01760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS01765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS01770	COG1120	ATPase activity
I6G95_RS01790	COG1764	response to oxidative stress
I6G95_RS01795	COG0183	Belongs to the thiolase family
I6G95_RS01800	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G95_RS01800	COG1024	Enoyl-CoA hydratase
I6G95_RS01820	COG4166	transmembrane transport
I6G95_RS01825	COG0601	transmembrane transport
I6G95_RS01830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G95_RS01850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6G95_RS01860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G95_RS01875	COG2391	methyltransferase activity
I6G95_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
I6G95_RS01895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G95_RS01900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G95_RS01905	COG2070	2-Nitropropane dioxygenase
I6G95_RS01915	COG1959	2 iron, 2 sulfur cluster binding
I6G95_RS01920	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6G95_RS01940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G95_RS01960	COG3104	oligopeptide transport
I6G95_RS01965	COG3830	Belongs to the UPF0237 family
I6G95_RS01970	COG2848	UPF0210 protein
I6G95_RS01980	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6G95_RS02000	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G95_RS02005	COG0671	phosphoesterase, PA-phosphatase related
I6G95_RS02010	COG1216	Glycosyl transferase, family 2
I6G95_RS02040	COG0561	phosphatase activity
I6G95_RS02050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G95_RS02055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G95_RS02060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G95_RS02065	COG2267	carboxylic ester hydrolase activity
I6G95_RS02085	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6G95_RS02100	COG1280	lysine exporter protein (LysE YggA)
I6G95_RS02125	COG0077	Prephenate dehydratase
I6G95_RS02135	COG3001	Fructosamine kinase
I6G95_RS02140	COG1316	TRANSCRIPTIONal
I6G95_RS02155	COG0469	pyruvate kinase activity
I6G95_RS02230	COG0577	efflux transmembrane transporter activity
I6G95_RS02295	COG1842	Phage shock protein A
I6G95_RS02305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G95_RS02310	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G95_RS02320	COG0305	Participates in initiation and elongation during chromosome replication
I6G95_RS02325	COG0359	binds to the 23S rRNA
I6G95_RS02330	COG0629	single-stranded DNA binding
I6G95_RS02335	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G95_RS02345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G95_RS02355	COG1260	myo-inositol-1-phosphate synthase
I6G95_RS02375	COG0495	leucyl-tRNA aminoacylation
I6G95_RS02410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G95_RS02415	COG1678	Uncharacterized ACR, COG1678
I6G95_RS02420	COG0617	tRNA 3'-terminal CCA addition
I6G95_RS02450	COG3118	belongs to the thioredoxin family
I6G95_RS02455	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G95_RS02455	COG3409	Peptidoglycan-binding domain 1 protein
I6G95_RS02470	COG1192	Involved in chromosome partitioning
I6G95_RS02475	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G95_RS02485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G95_RS02495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G95_RS02500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G95_RS02505	COG0592	DNA-directed DNA polymerase activity
I6G95_RS02510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G95_RS02515	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6G95_RS02520	COG0187	DNA topoisomerase II activity
I6G95_RS02540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G95_RS02580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G95_RS02595	COG0515	serine threonine protein kinase
I6G95_RS02595	COG2815	serine threonine protein kinase
I6G95_RS02600	COG0515	serine threonine protein kinase
I6G95_RS02605	COG0768	penicillin binding
I6G95_RS02620	COG1716	ATPase activity
I6G95_RS02625	COG1716	ATPase activity
I6G95_RS02625	COG1716	ATPase activity
I6G95_RS02680	COG1247	-acetyltransferase
I6G95_RS02685	COG2072	flavoprotein involved in K transport
I6G95_RS02690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G95_RS02695	COG0667	Aldo Keto reductase
I6G95_RS02735	COG1518	maintenance of DNA repeat elements
I6G95_RS02765	COG1028	Short-chain dehydrogenase reductase Sdr
I6G95_RS02770	COG3268	Saccharopine dehydrogenase
I6G95_RS02775	COG2814	Major facilitator Superfamily
I6G95_RS02780	COG3177	Filamentation induced by cAMP protein fic
I6G95_RS02790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G95_RS02795	COG5650	phosphatidylinositol metabolic process
I6G95_RS02800	COG1643	Atp-dependent helicase
I6G95_RS02805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G95_RS02815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G95_RS02835	COG1902	pentaerythritol trinitrate reductase activity
I6G95_RS02835	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G95_RS02850	COG0318	PFAM AMP-dependent synthetase and ligase
I6G95_RS02860	COG4974	Belongs to the 'phage' integrase family
I6G95_RS02890	COG2226	methyltransferase
I6G95_RS02895	COG0028	Belongs to the TPP enzyme family
I6G95_RS02900	COG0574	Belongs to the PEP-utilizing enzyme family
I6G95_RS02900	COG3848	Pyruvate phosphate dikinase
I6G95_RS02905	COG2814	Major facilitator Superfamily
I6G95_RS02915	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS02920	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS02935	COG0070	glutamate synthase
I6G95_RS02935	COG0067	glutamate synthase
I6G95_RS02935	COG0069	glutamate synthase activity
I6G95_RS02950	COG1086	Polysaccharide biosynthesis protein
I6G95_RS02965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G95_RS02975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G95_RS02990	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G95_RS03000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G95_RS03020	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS03030	COG2501	S4 domain
I6G95_RS03040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G95_RS03040	COG0473	3-isopropylmalate dehydrogenase activity
I6G95_RS03055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS03060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6G95_RS03075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G95_RS03095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G95_RS03100	COG1136	(ABC) transporter
I6G95_RS03115	COG2390	Transcriptional regulator
I6G95_RS03120	COG3590	peptidase
I6G95_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
I6G95_RS03150	COG0277	FAD linked oxidase domain protein
I6G95_RS03175	COG1216	Glycosyl transferase, family 2
I6G95_RS03195	COG1216	Glycosyl transferase, family 2
I6G95_RS03245	COG2801	Transposase and inactivated derivatives
I6G95_RS03245	COG3415	Transposase
I6G95_RS03280	COG2801	Transposase and inactivated derivatives
I6G95_RS03280	COG3415	Transposase
I6G95_RS03290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G95_RS03310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G95_RS03315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G95_RS03320	COG0287	Prephenate dehydrogenase
I6G95_RS03335	COG3237	CsbD-like
I6G95_RS03340	COG1748	Saccharopine dehydrogenase
I6G95_RS03350	COG2409	Drug exporters of the RND superfamily
I6G95_RS03355	COG0343	queuine tRNA-ribosyltransferase activity
I6G95_RS03360	COG1131	(ABC) transporter
I6G95_RS03375	COG0640	Transcriptional regulator
I6G95_RS03385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G95_RS03410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G95_RS03430	COG1937	Protein conserved in bacteria
I6G95_RS03465	COG0659	secondary active sulfate transmembrane transporter activity
I6G95_RS03470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G95_RS03490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G95_RS03495	COG3442	glutamine amidotransferase
I6G95_RS03500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G95_RS03535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G95_RS03545	COG1511	domain protein
I6G95_RS03555	COG0697	spore germination
I6G95_RS03560	COG0527	aspartate kinase activity
I6G95_RS03580	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS03660	COG1136	(ABC) transporter
I6G95_RS03660	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G95_RS03700	COG0651	ATP synthesis coupled electron transport
I6G95_RS03705	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G95_RS03710	COG2111	Na H antiporter
I6G95_RS03710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G95_RS03720	COG2226	methyltransferase
I6G95_RS03745	COG1129	ABC transporter
I6G95_RS03750	COG2375	cellular response to nickel ion
I6G95_RS03750	COG1132	(ABC) transporter
I6G95_RS03755	COG1132	(ABC) transporter
I6G95_RS03760	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS03805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G95_RS03845	COG1408	metallophosphoesterase
I6G95_RS03880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G95_RS03925	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS03965	COG1111	helicase
I6G95_RS03965	COG1205	dead DEAH box helicase
I6G95_RS03975	COG1754	DNA topoisomerase type I activity
I6G95_RS03975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G95_RS03990	COG3655	Transcriptional regulator
I6G95_RS04000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G95_RS04020	COG0477	Major facilitator Superfamily
I6G95_RS04025	COG2814	Major facilitator Superfamily
I6G95_RS04030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G95_RS04065	COG1505	serine-type exopeptidase activity
I6G95_RS04070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G95_RS04085	COG1396	sequence-specific DNA binding
I6G95_RS04085	COG3800	Transcriptional regulator
I6G95_RS04090	COG2224	Isocitrate lyase
I6G95_RS04095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G95_RS04115	COG1053	succinate dehydrogenase
I6G95_RS04120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G95_RS04130	COG2733	membrane
I6G95_RS04140	COG0788	formyltetrahydrofolate deformylase activity
I6G95_RS04155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G95_RS04160	COG0318	PFAM AMP-dependent synthetase and ligase
I6G95_RS04165	COG0438	transferase activity, transferring glycosyl groups
I6G95_RS04175	COG0588	phosphoglycerate mutase activity
I6G95_RS04180	COG5002	protein histidine kinase activity
I6G95_RS04205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G95_RS04235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G95_RS04240	COG0181	hydroxymethylbilane synthase activity
I6G95_RS04275	COG0406	alpha-ribazole phosphatase activity
I6G95_RS04290	COG1333	cytochrome c biogenesis protein
I6G95_RS04295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G95_RS04300	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G95_RS04310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G95_RS04345	COG3949	Membrane
I6G95_RS04355	COG1131	(ABC) transporter
I6G95_RS04360	COG2197	response regulator
I6G95_RS04365	COG4585	Histidine kinase
I6G95_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
I6G95_RS04380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G95_RS04400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G95_RS04410	COG1124	(ABC) transporter
I6G95_RS04420	COG0019	diaminopimelate decarboxylase activity
I6G95_RS04425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G95_RS04430	COG0534	Mate efflux family protein
I6G95_RS04440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS04445	COG1120	ATPase activity
I6G95_RS04450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G95_RS04455	COG4948	Mandelate Racemase Muconate Lactonizing
I6G95_RS04460	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS04465	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G95_RS04475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G95_RS04475	COG0438	transferase activity, transferring glycosyl groups
I6G95_RS04485	COG0644	oxidoreductase
I6G95_RS04490	COG0142	geranyltranstransferase activity
I6G95_RS04530	COG0250	Participates in transcription elongation, termination and antitermination
I6G95_RS04535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G95_RS04550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G95_RS04555	COG0222	ribosome binding
I6G95_RS04565	COG0085	RNA polymerase activity
I6G95_RS04570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G95_RS04575	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS04590	COG0049	tRNA binding
I6G95_RS04600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G95_RS04605	COG0051	transcription antitermination factor activity, RNA binding
I6G95_RS04610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G95_RS04615	COG0088	Forms part of the polypeptide exit tunnel
I6G95_RS04620	COG0089	rRNA binding
I6G95_RS04625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G95_RS04630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G95_RS04635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G95_RS04640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G95_RS04645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G95_RS04650	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G95_RS04660	COG2239	Acts as a magnesium transporter
I6G95_RS04665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G95_RS04670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G95_RS04675	COG1621	beta-fructofuranosidase activity
I6G95_RS04695	COG2814	Major facilitator Superfamily
I6G95_RS04705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G95_RS04725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G95_RS04735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G95_RS04740	COG1841	ribosomal large subunit assembly
I6G95_RS04745	COG0200	Binds to the 23S rRNA
I6G95_RS04755	COG0156	8-amino-7-oxononanoate synthase activity
I6G95_RS04760	COG0201	protein transport
I6G95_RS04765	COG0563	adenylate kinase activity
I6G95_RS04790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G95_RS04795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G95_RS04800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G95_RS04805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G95_RS04845	COG1404	Belongs to the peptidase S8 family
I6G95_RS04855	COG1674	ftsk spoiiie
I6G95_RS04880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G95_RS04885	COG2755	lipolytic protein G-D-S-L family
I6G95_RS04885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G95_RS04895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G95_RS04900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G95_RS04925	COG3425	synthase
I6G95_RS04950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G95_RS04965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G95_RS04965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G95_RS04970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G95_RS04975	COG0456	acetyltransferase
I6G95_RS04975	COG1214	PFAM Peptidase M22, glycoprotease
I6G95_RS04980	COG0456	acetyltransferase
I6G95_RS04985	COG0028	Belongs to the TPP enzyme family
I6G95_RS05000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G95_RS05005	COG0459	protein refolding
I6G95_RS05030	COG0516	GMP reductase activity
I6G95_RS05040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G95_RS05040	COG0519	Catalyzes the synthesis of GMP from XMP
I6G95_RS05060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G95_RS05075	COG2011	ABC-type metal ion transport system permease component
I6G95_RS05080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G95_RS05085	COG1464	Belongs to the NlpA lipoprotein family
I6G95_RS05090	COG0587	DNA-directed DNA polymerase activity
I6G95_RS05100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G95_RS05105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G95_RS05115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G95_RS05120	COG2873	o-acetylhomoserine
I6G95_RS05125	COG2838	Isocitrate dehydrogenase
I6G95_RS05135	COG2814	Major facilitator Superfamily
I6G95_RS05155	COG0180	Tryptophanyl-tRNA synthetase
I6G95_RS05160	COG1295	ribonuclease BN
I6G95_RS05165	COG1686	Belongs to the peptidase S11 family
I6G95_RS05175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G95_RS05185	COG0791	NLP P60 protein
I6G95_RS05195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G95_RS05205	COG1473	amidohydrolase
I6G95_RS05205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6G95_RS05215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G95_RS05220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G95_RS05225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G95_RS05230	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G95_RS05235	COG3304	Inner membrane component domain
I6G95_RS05250	COG1605	Chorismate mutase
I6G95_RS05280	COG0138	bifunctional purine biosynthesis protein purh
I6G95_RS05290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G95_RS05300	COG1960	acyl-CoA dehydrogenase activity
I6G95_RS05315	COG0318	PFAM AMP-dependent synthetase and ligase
I6G95_RS05320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G95_RS05330	COG0183	Belongs to the thiolase family
I6G95_RS05345	COG0298	carbon dioxide binding
I6G95_RS05355	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G95_RS05360	COG0375	protein maturation
I6G95_RS05375	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G95_RS05385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G95_RS05390	COG0375	protein maturation
I6G95_RS05395	COG3259	Nickel-dependent hydrogenase
I6G95_RS05405	COG1316	TRANSCRIPTIONal
I6G95_RS05440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G95_RS05450	COG1482	cell wall glycoprotein biosynthetic process
I6G95_RS05475	COG0745	RESPONSE REGULATOR receiver
I6G95_RS05480	COG5002	protein histidine kinase activity
I6G95_RS05495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G95_RS05500	COG0653	protein targeting
I6G95_RS05605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G95_RS05605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G95_RS05680	COG0740	serine-type endopeptidase activity
I6G95_RS05830	COG1162	GTPase activity
I6G95_RS05835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G95_RS05845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G95_RS05855	COG5662	AntiSigma factor
I6G95_RS05870	COG1597	lipid kinase activity
I6G95_RS05885	COG0513	Belongs to the DEAD box helicase family
I6G95_RS05905	COG0210	DNA helicase
I6G95_RS05910	COG0210	DNA helicase
I6G95_RS05940	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6G95_RS05945	COG1115	amino acid carrier protein
I6G95_RS06000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G95_RS06005	COG2814	Major facilitator Superfamily
I6G95_RS06010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G95_RS06025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G95_RS06030	COG0813	purine-nucleoside phosphorylase activity
I6G95_RS06040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G95_RS06045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G95_RS06050	COG0560	Phosphoserine phosphatase
I6G95_RS06050	COG3830	Belongs to the UPF0237 family
I6G95_RS06060	COG0318	PFAM AMP-dependent synthetase and ligase
I6G95_RS06070	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G95_RS06075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G95_RS06085	COG3191	aminopeptidase activity
I6G95_RS06095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G95_RS06105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G95_RS06185	COG1376	ErfK ybiS ycfS ynhG family protein
I6G95_RS06190	COG2197	response regulator
I6G95_RS06195	COG4585	Histidine kinase
I6G95_RS06200	COG0577	efflux transmembrane transporter activity
I6G95_RS06205	COG0577	efflux transmembrane transporter activity
I6G95_RS06205	COG1136	(ABC) transporter
I6G95_RS06210	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS06220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G95_RS06230	COG2801	Transposase and inactivated derivatives
I6G95_RS06230	COG3415	Transposase
I6G95_RS06240	COG3336	cytochrome c oxidase
I6G95_RS06245	COG0629	single-stranded DNA binding
I6G95_RS06275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G95_RS06280	COG0535	radical SAM domain protein
I6G95_RS06285	COG0698	ribose 5-phosphate isomerase
I6G95_RS06315	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G95_RS06320	COG0740	serine-type endopeptidase activity
I6G95_RS06325	COG0740	serine-type endopeptidase activity
I6G95_RS06340	COG0039	L-malate dehydrogenase activity
I6G95_RS06345	COG0525	valine-tRNA ligase activity
I6G95_RS06350	COG0285	dihydrofolate synthase activity
I6G95_RS06365	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS06375	COG1530	ribonuclease E activity
I6G95_RS06380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G95_RS06385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G95_RS06390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G95_RS06395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G95_RS06400	COG3764	Sortase (surface protein transpeptidase)
I6G95_RS06410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G95_RS06415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G95_RS06425	COG0406	alpha-ribazole phosphatase activity
I6G95_RS06430	COG1307	EDD domain protein, DegV family
I6G95_RS06455	COG0268	Binds directly to 16S ribosomal RNA
I6G95_RS06465	COG0481	GTPase activity
I6G95_RS06480	COG4651	solute:proton antiporter activity
I6G95_RS06480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G95_RS06490	COG0406	alpha-ribazole phosphatase activity
I6G95_RS06510	COG0732	type I restriction modification DNA specificity domain
I6G95_RS06540	COG0363	glucosamine-6-phosphate deaminase activity
I6G95_RS06565	COG2130	NADP-dependent
I6G95_RS06575	COG2860	membrane
I6G95_RS06585	COG1132	(ABC) transporter
I6G95_RS06600	COG1120	ATPase activity
I6G95_RS06605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS06615	COG2271	Major facilitator Superfamily
I6G95_RS06620	COG1393	Belongs to the ArsC family
I6G95_RS06630	COG1121	(ABC) transporter
I6G95_RS06635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G95_RS06645	COG1321	iron dependent repressor
I6G95_RS06660	COG1028	Short-chain dehydrogenase reductase Sdr
I6G95_RS06660	COG0604	alcohol dehydrogenase
I6G95_RS06660	COG3321	synthase
I6G95_RS06670	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G95_RS06675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G95_RS06680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G95_RS06685	COG1984	allophanate hydrolase subunit 2
I6G95_RS06695	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G95_RS06700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G95_RS06710	COG1309	transcriptional regulator
I6G95_RS06715	COG0477	Major facilitator Superfamily
I6G95_RS06810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G95_RS06830	COG1362	aminopeptidase activity
I6G95_RS06835	COG1473	amidohydrolase
I6G95_RS06840	COG0366	Alpha amylase catalytic
I6G95_RS06855	COG4721	ABC-type cobalt transport system, permease component
I6G95_RS06860	COG4172	Belongs to the ABC transporter superfamily
I6G95_RS06900	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS06975	COG0629	single-stranded DNA binding
I6G95_RS07015	COG0863	Belongs to the N(4) N(6)-methyltransferase family
I6G95_RS07060	COG0756	dUTP diphosphatase activity
I6G95_RS07235	COG1217	gtp-binding protein TYPA
I6G95_RS07240	COG4166	transmembrane transport
I6G95_RS07245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G95_RS07265	COG0564	pseudouridine synthase activity
I6G95_RS07275	COG1113	amino acid transport
I6G95_RS07290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G95_RS07295	COG1611	Belongs to the LOG family
I6G95_RS07300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G95_RS07315	COG3527	Alpha-acetolactate decarboxylase
I6G95_RS07325	COG0297	glycogen (starch) synthase activity
I6G95_RS07330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G95_RS07335	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS07355	COG4122	O-methyltransferase activity
I6G95_RS07370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G95_RS07375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G95_RS07380	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS07390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G95_RS07395	COG1690	Belongs to the RtcB family
I6G95_RS07400	COG0019	diaminopimelate decarboxylase activity
I6G95_RS07425	COG0598	Magnesium transport protein CorA
I6G95_RS07435	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G95_RS07435	COG0567	Dehydrogenase, E1 component
I6G95_RS07440	COG1132	(ABC) transporter
I6G95_RS07490	COG0385	Bile acid
I6G95_RS07510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G95_RS07515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G95_RS07525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G95_RS07550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS07555	COG1120	ATPase activity
I6G95_RS07565	COG1556	Lactate utilization protein
I6G95_RS07570	COG1139	Iron-sulfur cluster binding protein
I6G95_RS07575	COG0247	lactate metabolic process
I6G95_RS07580	COG0018	arginyl-trna synthetase
I6G95_RS07585	COG0019	diaminopimelate decarboxylase activity
I6G95_RS07590	COG0460	homoserine dehydrogenase
I6G95_RS07595	COG0083	homoserine kinase activity
I6G95_RS07600	COG0318	PFAM AMP-dependent synthetase and ligase
I6G95_RS07610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G95_RS07625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G95_RS07635	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G95_RS07640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G95_RS07645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G95_RS07650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G95_RS07655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G95_RS07660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G95_RS07665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G95_RS07725	COG0366	Alpha amylase catalytic
I6G95_RS07730	COG1119	ATPase activity
I6G95_RS07750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G95_RS07785	COG0058	SHG alpha-glucan phosphorylase activity
I6G95_RS07795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G95_RS07800	COG0154	amidase activity
I6G95_RS07805	COG4139	cobalamin transport
I6G95_RS07810	COG1120	ATPase activity
I6G95_RS07820	COG0205	6-phosphofructokinase activity
I6G95_RS07825	COG3949	Membrane
I6G95_RS07835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G95_RS07855	COG0129	dihydroxy-acid dehydratase activity
I6G95_RS07865	COG0668	transmembrane transport
I6G95_RS07870	COG0028	Belongs to the TPP enzyme family
I6G95_RS07880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G95_RS07900	COG0523	cobalamin synthesis protein
I6G95_RS07915	COG0473	3-isopropylmalate dehydrogenase activity
I6G95_RS07925	COG1125	glycine betaine transport
I6G95_RS07925	COG0517	IMP dehydrogenase activity
I6G95_RS07930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G95_RS07935	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS07945	COG0675	Transposase, IS605 OrfB family
I6G95_RS07965	COG1132	(ABC) transporter
I6G95_RS08020	COG1120	ATPase activity
I6G95_RS08025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS08030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G95_RS08035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G95_RS08045	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G95_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
I6G95_RS08060	COG3622	Belongs to the hyi family
I6G95_RS08065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G95_RS08090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G95_RS08105	COG0039	L-malate dehydrogenase activity
I6G95_RS08115	COG0583	DNA-binding transcription factor activity
I6G95_RS08125	COG2271	Major facilitator Superfamily
I6G95_RS08135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G95_RS08145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G95_RS08150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G95_RS08155	COG0494	nUDIX hydrolase
I6G95_RS08155	COG0406	alpha-ribazole phosphatase activity
I6G95_RS08160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G95_RS08180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G95_RS08200	COG4770	biotin carboxylase activity
I6G95_RS08205	COG0742	ribosomal rna small subunit methyltransferase
I6G95_RS08210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G95_RS08225	COG0571	ribonuclease III activity
I6G95_RS08235	COG1115	amino acid carrier protein
I6G95_RS08240	COG1254	Belongs to the acylphosphatase family
I6G95_RS08245	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS08255	COG1196	nuclear chromosome segregation
I6G95_RS08290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G95_RS08295	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G95_RS08300	COG0671	phosphoesterase, PA-phosphatase related
I6G95_RS08325	COG0335	large ribosomal subunit rRNA binding
I6G95_RS08330	COG0681	Belongs to the peptidase S26 family
I6G95_RS08335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G95_RS08345	COG0792	nuclease activity
I6G95_RS08370	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G95_RS08380	COG0528	UMP kinase activity
I6G95_RS08385	COG0233	cytoplasmic translational termination
I6G95_RS08400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G95_RS08445	COG0579	oxidoreductase
I6G95_RS08485	COG0442	prolyl-tRNA aminoacylation
I6G95_RS08505	COG0779	Required for maturation of 30S ribosomal subunits
I6G95_RS08520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G95_RS08535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G95_RS08560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G95_RS08565	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G95_RS08570	COG2017	converts alpha-aldose to the beta-anomer
I6G95_RS08585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G95_RS08590	COG2814	Major facilitator Superfamily
I6G95_RS08595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G95_RS08610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G95_RS08620	COG1674	ftsk spoiiie
I6G95_RS08640	COG1396	sequence-specific DNA binding
I6G95_RS08645	COG1842	Phage shock protein A
I6G95_RS08650	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G95_RS08655	COG1122	ATPase activity
I6G95_RS08660	COG1268	BioY protein
I6G95_RS08670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G95_RS08675	COG2137	regulation of response to DNA damage stimulus
I6G95_RS08680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G95_RS08690	COG1196	nuclear chromosome segregation
I6G95_RS08700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G95_RS08730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G95_RS08735	COG2233	PERMEase
I6G95_RS08745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G95_RS08745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G95_RS08745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G95_RS08750	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G95_RS08755	COG1349	DNA-binding transcription factor activity
I6G95_RS08760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G95_RS08770	COG1643	Atp-dependent helicase
I6G95_RS08775	COG1054	Belongs to the UPF0176 family
I6G95_RS08780	COG4868	Belongs to the UPF0371 family
I6G95_RS08800	COG0450	alkyl hydroperoxide reductase
I6G95_RS08805	COG0583	DNA-binding transcription factor activity
I6G95_RS08825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G95_RS08830	COG1321	iron dependent repressor
I6G95_RS08845	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G95_RS08870	COG0471	metal ion transport
I6G95_RS08885	COG0483	inositol monophosphate 1-phosphatase activity
I6G95_RS08905	COG0756	dUTP diphosphatase activity
I6G95_RS08935	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G95_RS08945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G95_RS09015	COG2837	iron assimilation
I6G95_RS09030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G95_RS09035	COG1560	Kdo2-lipid A biosynthetic process
I6G95_RS09040	COG0438	transferase activity, transferring glycosyl groups
I6G95_RS09050	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6G95_RS09055	COG1946	Acyl-CoA thioesterase
I6G95_RS09065	COG0217	transcriptional regulatory protein
I6G95_RS09075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G95_RS09080	COG0632	four-way junction helicase activity
I6G95_RS09095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G95_RS09100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G95_RS09110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G95_RS09115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G95_RS09125	COG0124	histidyl-tRNA synthetase
I6G95_RS09135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G95_RS09155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G95_RS09175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G95_RS09180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G95_RS09185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G95_RS09195	COG0006	proline dipeptidase activity
I6G95_RS09200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G95_RS09205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G95_RS09215	COG0540	Belongs to the ATCase OTCase family
I6G95_RS09220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G95_RS09230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G95_RS09235	COG0284	orotidine-5'-phosphate decarboxylase activity
I6G95_RS09245	COG0194	GDP metabolic process
I6G95_RS09250	COG1758	RNA polymerase activity
I6G95_RS09260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G95_RS09265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G95_RS09270	COG0242	peptide deformylase activity
I6G95_RS09275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G95_RS09305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G95_RS09315	COG0322	excinuclease ABC activity
I6G95_RS09320	COG1660	Displays ATPase and GTPase activities
I6G95_RS09330	COG1481	regulation of sporulation
I6G95_RS09335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G95_RS09340	COG0126	phosphoglycerate kinase activity
I6G95_RS09350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G95_RS09355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G95_RS09375	COG1725	Transcriptional regulator
I6G95_RS09380	COG1131	(ABC) transporter
I6G95_RS09390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G95_RS09400	COG0109	protoheme IX farnesyltransferase activity
I6G95_RS09410	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS09425	COG1131	(ABC) transporter
I6G95_RS09450	COG0396	ATPase activity
I6G95_RS09460	COG0822	iron-sulfur transferase activity
I6G95_RS09470	COG0833	amino acid
I6G95_RS09480	COG0488	(ABC) transporter
I6G95_RS09510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G95_RS09520	COG0791	NLP P60 protein
I6G95_RS09520	COG3883	PFAM NLP P60 protein
I6G95_RS09525	COG0714	Associated with various cellular activities
I6G95_RS09535	COG2304	oxidoreductase activity
I6G95_RS09540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G95_RS09590	COG0640	Transcriptional regulator
I6G95_RS09615	COG3415	Transposase
I6G95_RS09615	COG2801	Transposase and inactivated derivatives
I6G95_RS09635	COG0167	dihydroorotate dehydrogenase activity
I6G95_RS09650	COG1968	undecaprenyl-diphosphatase activity
I6G95_RS09655	COG0215	cysteine-tRNA ligase activity
I6G95_RS09665	COG1410	methionine synthase
I6G95_RS09665	COG0646	methionine synthase
I6G95_RS09675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G95_RS09690	COG1027	Aspartate ammonia-lyase
I6G95_RS09710	COG1222	aaa ATPase
I6G95_RS09725	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6G95_RS09740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G95_RS09745	COG0805	protein transport
I6G95_RS09840	COG1253	flavin adenine dinucleotide binding
I6G95_RS09850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G95_RS09860	COG3573	Dehydrogenase
I6G95_RS09880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G95_RS09885	COG0351	phosphomethylpyrimidine kinase
I6G95_RS09885	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G95_RS09885	COG0352	thiamine-phosphate diphosphorylase activity
I6G95_RS09895	COG1253	flavin adenine dinucleotide binding
I6G95_RS09935	COG1716	ATPase activity
I6G95_RS09940	COG0653	protein targeting
I6G95_RS09945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G95_RS09960	COG1160	GTP binding
I6G95_RS09970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G95_RS09975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G95_RS09985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G95_RS10005	COG0494	nUDIX hydrolase
I6G95_RS10010	COG0504	CTP synthase activity
I6G95_RS10015	COG0693	protein deglycase activity
I6G95_RS10040	COG1715	Restriction endonuclease
I6G95_RS10045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G95_RS10055	COG1201	RNA secondary structure unwinding
I6G95_RS10070	COG1192	Involved in chromosome partitioning
I6G95_RS10090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G95_RS10105	COG0647	UMP catabolic process
I6G95_RS10115	COG0328	RNA-DNA hybrid ribonuclease activity
I6G95_RS10140	COG2365	Tyrosine phosphatase family
I6G95_RS10160	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS10170	COG2094	Belongs to the DNA glycosylase MPG family
I6G95_RS10195	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS10200	COG0165	Argininosuccinate lyase
I6G95_RS10205	COG0137	argininosuccinate synthase activity
I6G95_RS10210	COG1438	arginine binding
I6G95_RS10215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G95_RS10220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G95_RS10225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G95_RS10230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G95_RS10235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G95_RS10245	COG0072	phenylalanine-tRNA ligase activity
I6G95_RS10245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G95_RS10250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G95_RS10255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G95_RS10260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G95_RS10265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G95_RS10285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G95_RS10300	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS10335	COG0237	dephospho-CoA kinase activity
I6G95_RS10340	COG0435	Glutathione S-transferase
I6G95_RS10345	COG0539	negative regulation of cytoplasmic translation
I6G95_RS10385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G95_RS10390	COG0765	amino acid transport
I6G95_RS10395	COG1126	abc transporter atp-binding protein
I6G95_RS10405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G95_RS10425	COG0469	pyruvate kinase activity
I6G95_RS10430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G95_RS10435	COG0159	tryptophan synthase activity
I6G95_RS10445	COG0134	indole-3-glycerol-phosphate synthase activity
I6G95_RS10455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G95_RS10460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G95_RS10465	COG0107	imidazoleglycerol-phosphate synthase activity
I6G95_RS10470	COG0483	inositol monophosphate 1-phosphatase activity
I6G95_RS10475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G95_RS10480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G95_RS10510	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G95_RS10515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G95_RS10520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G95_RS10545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G95_RS10570	COG1309	transcriptional regulator
I6G95_RS10575	COG2056	Na+-H+ antiporter family
I6G95_RS10640	COG1739	Uncharacterized protein family UPF0029
I6G95_RS10655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G95_RS10670	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G95_RS10675	COG0314	molybdopterin synthase activity
I6G95_RS10685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G95_RS10695	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G95_RS10700	COG0746	molybdenum cofactor guanylyltransferase activity
I6G95_RS10720	COG1140	nitrate reductase beta subunit
I6G95_RS10775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G95_RS10790	COG0252	asparaginase activity
I6G95_RS10800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G95_RS10805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G95_RS10810	COG3599	regulation of cell shape
I6G95_RS10820	COG1799	cell septum assembly
I6G95_RS10825	COG1496	oxidoreductase activity
I6G95_RS10830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G95_RS10835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G95_RS10840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G95_RS10845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G95_RS10855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G95_RS10860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G95_RS10870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G95_RS10875	COG0768	penicillin binding
I6G95_RS10885	COG0275	rRNA processing
I6G95_RS10890	COG2001	Belongs to the MraZ family
I6G95_RS10905	COG0456	acetyltransferase
I6G95_RS10920	COG0142	geranyltranstransferase activity
I6G95_RS10950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6G95_RS10970	COG0438	transferase activity, transferring glycosyl groups
I6G95_RS10980	COG0791	NLP P60 protein
I6G95_RS10990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G95_RS11005	COG0723	plastoquinol--plastocyanin reductase activity
I6G95_RS11015	COG0488	(ABC) transporter
I6G95_RS11050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6G95_RS11055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6G95_RS11065	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS11070	COG2826	transposase and inactivated derivatives, IS30 family
I6G95_RS11080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G95_RS11085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G95_RS11090	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G95_RS11100	COG0321	lipoyl(octanoyl) transferase activity
I6G95_RS11115	COG2985	domain, Protein
I6G95_RS11115	COG0569	domain protein
I6G95_RS11125	COG0174	glutamine synthetase
I6G95_RS11130	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS11135	COG0174	glutamine synthetase
I6G95_RS11140	COG1983	PspC domain protein
I6G95_RS11155	COG2818	Glycosylase
I6G95_RS11185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G95_RS11190	COG1114	Component of the transport system for branched-chain amino acids
I6G95_RS11200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G95_RS11205	COG0028	Belongs to the TPP enzyme family
I6G95_RS11210	COG2223	nitrite transmembrane transporter activity
I6G95_RS11220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G95_RS11225	COG0174	glutamine synthetase
I6G95_RS11230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G95_RS11265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G95_RS11265	COG3323	Protein of unknown function (DUF1653)
I6G95_RS11275	COG0546	phosphoglycolate phosphatase activity
I6G95_RS11315	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G95_RS11335	COG1823	symporter activity
I6G95_RS11340	COG0477	Major facilitator Superfamily
I6G95_RS11360	COG3421	Type III restriction
I6G95_RS11375	COG1435	thymidine kinase activity
I6G95_RS11380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G95_RS11380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G95_RS11385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G95_RS11395	COG1136	(ABC) transporter
I6G95_RS11405	COG2197	response regulator
I6G95_RS11410	COG1012	belongs to the aldehyde dehydrogenase family
I6G95_RS11450	COG5640	endopeptidase activity
I6G95_RS11460	COG0745	RESPONSE REGULATOR receiver
I6G95_RS11465	COG2205	protein histidine kinase activity
I6G95_RS11500	COG0358	DNA primase activity
I6G95_RS11515	COG1309	transcriptional regulator
I6G95_RS11520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6G95_RS11540	COG0423	glycine-tRNA ligase activity
I6G95_RS11550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G95_RS11555	COG1381	Involved in DNA repair and RecF pathway recombination
I6G95_RS11570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G95_RS11575	COG1702	phosphate starvation-inducible protein PhoH
I6G95_RS11590	COG1420	regulation of RNA biosynthetic process
I6G95_RS11605	COG1022	Amp-dependent synthetase and ligase
I6G95_RS11620	COG0339	signal peptide processing
I6G95_RS11625	COG2272	Belongs to the type-B carboxylesterase lipase family
I6G95_RS11630	COG3402	PFAM membrane-flanked domain
I6G95_RS11640	COG0366	Alpha amylase catalytic
I6G95_RS11650	COG1132	(ABC) transporter
I6G95_RS11660	COG0277	FAD linked oxidase domain protein
I6G95_RS11675	COG0671	phosphoesterase, PA-phosphatase related
I6G95_RS11695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G95_RS11700	COG1335	isochorismatase
I6G95_RS11705	COG2354	Protein conserved in bacteria
I6G95_RS11710	COG3012	SEC-C Motif Domain Protein
I6G95_RS11720	COG2066	Belongs to the glutaminase family
I6G95_RS11800	COG2217	Heavy metal translocating P-type atpase
I6G95_RS11810	COG2205	protein histidine kinase activity
I6G95_RS11815	COG0745	RESPONSE REGULATOR receiver
I6G95_RS11825	COG2132	Multicopper oxidase
I6G95_RS11850	COG0789	Transcriptional regulator
I6G95_RS11870	COG0012	GTP binding
I6G95_RS11900	COG1494	fructose-1,6-bisphosphatase
I6G95_RS11905	COG0114	fumarate hydratase activity
I6G95_RS11910	COG1309	transcriptional regulator
I6G95_RS11935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G95_RS11940	COG1960	acyl-CoA dehydrogenase activity
I6G95_RS11945	COG0733	neurotransmitter:sodium symporter activity
I6G95_RS11955	COG1024	Enoyl-CoA hydratase
I6G95_RS11975	COG1072	(Pantothenic acid kinase))
I6G95_RS11985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G95_RS11995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G95_RS12005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G95_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
I6G95_RS12045	COG0148	phosphopyruvate hydratase activity
I6G95_RS12055	COG3956	TIGRFAM MazG family protein
I6G95_RS12075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G95_RS12080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G95_RS12085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G95_RS12090	COG0193	aminoacyl-tRNA hydrolase activity
I6G95_RS12095	COG1132	(ABC) transporter
I6G95_RS12100	COG2375	cellular response to nickel ion
I6G95_RS12100	COG1132	(ABC) transporter
I6G95_RS12135	COG1122	ATPase activity
I6G95_RS12175	COG1132	(ABC) transporter
I6G95_RS12180	COG1132	(ABC) transporter
I6G95_RS12180	COG2375	cellular response to nickel ion
I6G95_RS12210	COG0561	phosphatase activity
I6G95_RS12215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G95_RS12250	COG2326	polyphosphate kinase activity
I6G95_RS12255	COG2177	Part of the ABC transporter FtsEX involved in
I6G95_RS12260	COG2884	Cell division ATP-binding protein ftsE
I6G95_RS12265	COG3547	Transposase (IS116 IS110 IS902 family)
I6G95_RS12275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G95_RS12280	COG0483	inositol monophosphate 1-phosphatase activity
I6G95_RS12285	COG0483	inositol monophosphate 1-phosphatase activity
I6G95_RS12295	COG0798	PFAM Bile acid sodium symporter
I6G95_RS12300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G95_RS12330	COG1615	UPF0182 protein
I6G95_RS12365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G95_RS12395	COG0488	(ABC) transporter