locus-tag	class	description
I6I66_RS00020	COG1121	(ABC) transporter
I6I66_RS00025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I66_RS00070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I66_RS00085	COG3527	Alpha-acetolactate decarboxylase
I6I66_RS00105	COG3842	ATPase activity
I6I66_RS00140	COG2190	(PTS) system
I6I66_RS00140	COG1263	PTS System
I6I66_RS00140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I66_RS00145	COG1263	PTS System
I6I66_RS00145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I66_RS00145	COG2190	(PTS) system
I6I66_RS00150	COG2723	6-phospho-beta-galactosidase activity
I6I66_RS00155	COG3711	transcriptional antiterminator
I6I66_RS00160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I66_RS00165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I66_RS00175	COG0424	maF-like protein
I6I66_RS00190	COG0189	ligase activity
I6I66_RS00195	COG2897	thiosulfate sulfurtransferase activity
I6I66_RS00200	COG4770	biotin carboxylase activity
I6I66_RS00220	COG0372	Belongs to the citrate synthase family
I6I66_RS00225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I66_RS00230	COG2079	MmgE PrpD family protein
I6I66_RS00235	COG1396	sequence-specific DNA binding
I6I66_RS00235	COG3800	Transcriptional regulator
I6I66_RS00250	COG1473	amidohydrolase
I6I66_RS00250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I66_RS00255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I66_RS00280	COG1686	Belongs to the peptidase S11 family
I6I66_RS00295	COG0180	Tryptophanyl-tRNA synthetase
I6I66_RS00310	COG2814	Major facilitator Superfamily
I6I66_RS00315	COG2838	Isocitrate dehydrogenase
I6I66_RS00335	COG0659	secondary active sulfate transmembrane transporter activity
I6I66_RS00365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I66_RS00375	COG2873	o-acetylhomoserine
I6I66_RS00380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I66_RS00390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I66_RS00395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I66_RS00435	COG0587	DNA-directed DNA polymerase activity
I6I66_RS00440	COG1464	Belongs to the NlpA lipoprotein family
I6I66_RS00455	COG2011	ABC-type metal ion transport system permease component
I6I66_RS00560	COG0459	protein refolding
I6I66_RS00565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I66_RS00575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I66_RS00580	COG0456	acetyltransferase
I6I66_RS00585	COG1214	PFAM Peptidase M22, glycoprotease
I6I66_RS00585	COG0456	acetyltransferase
I6I66_RS00595	COG0569	domain protein
I6I66_RS00595	COG2985	domain, Protein
I6I66_RS00605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I66_RS00635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I66_RS00665	COG1674	ftsk spoiiie
I6I66_RS00675	COG1404	Belongs to the peptidase S8 family
I6I66_RS00685	COG0101	tRNA pseudouridine synthase activity
I6I66_RS00690	COG0203	ribosomal protein L17
I6I66_RS00695	COG0202	RNA polymerase activity
I6I66_RS00700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I66_RS00705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I66_RS00710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I66_RS00730	COG0563	adenylate kinase activity
I6I66_RS00735	COG0201	protein transport
I6I66_RS00740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I66_RS00750	COG0200	Binds to the 23S rRNA
I6I66_RS00755	COG1841	ribosomal large subunit assembly
I6I66_RS00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I66_RS00765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I66_RS00770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I66_RS00785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I66_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I66_RS00800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I66_RS00805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I66_RS00820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I66_RS00860	COG1215	transferase activity, transferring glycosyl groups
I6I66_RS00870	COG1215	transferase activity, transferring glycosyl groups
I6I66_RS00875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I66_RS00880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I66_RS00900	COG1621	beta-fructofuranosidase activity
I6I66_RS00920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I66_RS00925	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I66_RS00930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I66_RS00935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I66_RS00940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I66_RS00945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I66_RS00950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I66_RS00955	COG0089	rRNA binding
I6I66_RS00960	COG0088	Forms part of the polypeptide exit tunnel
I6I66_RS00965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I66_RS00970	COG0051	transcription antitermination factor activity, RNA binding
I6I66_RS00975	COG1302	Protein conserved in bacteria
I6I66_RS01020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I66_RS01025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I66_RS01030	COG0049	tRNA binding
I6I66_RS01035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I66_RS01050	COG1122	ATPase activity
I6I66_RS01055	COG4721	ABC-type cobalt transport system, permease component
I6I66_RS01070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I66_RS01085	COG0222	ribosome binding
I6I66_RS01090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I66_RS01095	COG1120	ATPase activity
I6I66_RS01100	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I66_RS01105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I66_RS01135	COG0081	regulation of translation
I6I66_RS01140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I66_RS01150	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I66_RS01170	COG0435	Glutathione S-transferase
I6I66_RS01180	COG0142	geranyltranstransferase activity
I6I66_RS01190	COG2226	methyltransferase
I6I66_RS01195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I66_RS01195	COG0438	transferase activity, transferring glycosyl groups
I6I66_RS01220	COG4948	Mandelate Racemase Muconate Lactonizing
I6I66_RS01225	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I66_RS01235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I66_RS01250	COG1321	iron dependent repressor
I6I66_RS01255	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I66_RS01260	COG1121	(ABC) transporter
I6I66_RS01265	COG1321	iron dependent repressor
I6I66_RS01265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I66_RS01270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I66_RS01275	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I66_RS01295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I66_RS01300	COG1333	cytochrome c biogenesis protein
I6I66_RS01305	COG0785	Cytochrome C biogenesis protein
I6I66_RS01315	COG0406	alpha-ribazole phosphatase activity
I6I66_RS01320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I66_RS01335	COG1136	(ABC) transporter
I6I66_RS01340	COG1136	(ABC) transporter
I6I66_RS01340	COG0577	efflux transmembrane transporter activity
I6I66_RS01345	COG2076	Multidrug Resistance protein
I6I66_RS01355	COG2184	nucleotidyltransferase activity
I6I66_RS01360	COG2184	nucleotidyltransferase activity
I6I66_RS01365	COG1131	(ABC) transporter
I6I66_RS01385	COG0488	(ABC) transporter
I6I66_RS01390	COG2161	toxin-antitoxin pair type II binding
I6I66_RS01395	COG4115	mRNA cleavage
I6I66_RS01400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I66_RS01420	COG0113	porphobilinogen synthase activity
I6I66_RS01425	COG1648	precorrin-2 dehydrogenase activity
I6I66_RS01425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I66_RS01430	COG0181	hydroxymethylbilane synthase activity
I6I66_RS01435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I66_RS01470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I66_RS01490	COG0745	RESPONSE REGULATOR receiver
I6I66_RS01495	COG5002	protein histidine kinase activity
I6I66_RS01505	COG0438	transferase activity, transferring glycosyl groups
I6I66_RS01510	COG0318	PFAM AMP-dependent synthetase and ligase
I6I66_RS01515	COG0318	PFAM AMP-dependent synthetase and ligase
I6I66_RS01525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I66_RS01540	COG1854	S-ribosylhomocysteine lyase activity
I6I66_RS01545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I66_RS01565	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I66_RS01580	COG2733	membrane
I6I66_RS01620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I66_RS01625	COG3395	kinase activity
I6I66_RS01635	COG2186	Transcriptional regulator
I6I66_RS01645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I66_RS01650	COG1053	succinate dehydrogenase
I6I66_RS01660	COG1396	sequence-specific DNA binding
I6I66_RS01660	COG3800	Transcriptional regulator
I6I66_RS01665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I66_RS01685	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I66_RS01705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I66_RS01705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I66_RS01715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I66_RS01730	COG0318	PFAM AMP-dependent synthetase and ligase
I6I66_RS01735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I66_RS01735	COG2190	(PTS) system
I6I66_RS01735	COG1263	PTS System
I6I66_RS01740	COG0363	glucosamine-6-phosphate deaminase activity
I6I66_RS01745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I66_RS01775	COG1754	DNA topoisomerase type I activity
I6I66_RS01775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I66_RS01785	COG1278	Cold shock
I6I66_RS01790	COG1111	helicase
I6I66_RS01790	COG1205	dead DEAH box helicase
I6I66_RS01855	COG0596	Alpha beta hydrolase
I6I66_RS01860	COG4166	transmembrane transport
I6I66_RS01865	COG0601	transmembrane transport
I6I66_RS01870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I66_RS01905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I66_RS01915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I66_RS01920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I66_RS01950	COG1408	metallophosphoesterase
I6I66_RS01980	COG3949	Membrane
I6I66_RS01990	COG3764	Sortase (surface protein transpeptidase)
I6I66_RS02010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I66_RS02015	COG0527	aspartate kinase activity
I6I66_RS02020	COG0697	spore germination
I6I66_RS02045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I66_RS02075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I66_RS02095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I66_RS02110	COG1100	Small GTP-binding protein
I6I66_RS02170	COG0343	queuine tRNA-ribosyltransferase activity
I6I66_RS02175	COG2409	Drug exporters of the RND superfamily
I6I66_RS02210	COG0287	Prephenate dehydrogenase
I6I66_RS02245	COG0523	cobalamin synthesis protein
I6I66_RS02250	COG0471	metal ion transport
I6I66_RS02260	COG2149	membrane
I6I66_RS02265	COG0569	domain protein
I6I66_RS02270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I66_RS02295	COG3835	regulator
I6I66_RS02300	COG1113	amino acid transport
I6I66_RS02305	COG3961	Belongs to the TPP enzyme family
I6I66_RS02315	COG1950	PFAM Membrane protein of
I6I66_RS02370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I66_RS02380	COG2026	Addiction module toxin, RelE StbE family
I6I66_RS02395	COG0604	alcohol dehydrogenase
I6I66_RS02395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I66_RS02395	COG3321	synthase
I6I66_RS02395	COG4221	oxidoreductase activity
I6I66_RS02415	COG3177	Filamentation induced by cAMP protein fic
I6I66_RS02425	COG1216	Glycosyl transferase, family 2
I6I66_RS02455	COG0277	FAD linked oxidase domain protein
I6I66_RS02480	COG3590	peptidase
I6I66_RS02525	COG2501	S4 domain
I6I66_RS02530	COG1280	lysine exporter protein (LysE YggA)
I6I66_RS02545	COG0110	maltose O-acetyltransferase activity
I6I66_RS02550	COG1643	Atp-dependent helicase
I6I66_RS02555	COG0730	response to heat
I6I66_RS02560	COG3180	Ammonia monooxygenase
I6I66_RS02590	COG1528	Iron-storage protein
I6I66_RS02595	COG0659	secondary active sulfate transmembrane transporter activity
I6I66_RS02600	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I66_RS02605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I66_RS02615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I66_RS02625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I66_RS02630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I66_RS02730	COG2378	regulation of single-species biofilm formation
I6I66_RS02745	COG1716	ATPase activity
I6I66_RS02745	COG1716	ATPase activity
I6I66_RS02750	COG1716	ATPase activity
I6I66_RS02765	COG0768	penicillin binding
I6I66_RS02770	COG0515	serine threonine protein kinase
I6I66_RS02775	COG2815	serine threonine protein kinase
I6I66_RS02775	COG0515	serine threonine protein kinase
I6I66_RS02815	COG1131	(ABC) transporter
I6I66_RS02835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I66_RS02855	COG1132	(ABC) transporter
I6I66_RS02860	COG1132	(ABC) transporter
I6I66_RS02860	COG2375	cellular response to nickel ion
I6I66_RS02875	COG0726	polysaccharide deacetylase
I6I66_RS02915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I66_RS02940	COG0187	DNA topoisomerase II activity
I6I66_RS02950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I66_RS02955	COG0592	DNA-directed DNA polymerase activity
I6I66_RS02960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I66_RS02965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I66_RS02970	COG0594	ribonuclease P activity
I6I66_RS02975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I66_RS02985	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I66_RS02990	COG1192	Involved in chromosome partitioning
I6I66_RS03005	COG3409	Peptidoglycan-binding domain 1 protein
I6I66_RS03005	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I66_RS03010	COG3118	belongs to the thioredoxin family
I6I66_RS03030	COG2353	YceI-like domain
I6I66_RS03035	COG2826	transposase and inactivated derivatives, IS30 family
I6I66_RS03055	COG0617	tRNA 3'-terminal CCA addition
I6I66_RS03060	COG1678	Uncharacterized ACR, COG1678
I6I66_RS03065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I66_RS03110	COG0159	tryptophan synthase activity
I6I66_RS03120	COG0134	indole-3-glycerol-phosphate synthase activity
I6I66_RS03120	COG0135	phosphoribosylanthranilate isomerase activity
I6I66_RS03125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I66_RS03130	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I66_RS03135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I66_RS03150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I66_RS03150	COG1116	anion transmembrane transporter activity
I6I66_RS03165	COG0477	Major facilitator Superfamily
I6I66_RS03175	COG1802	Transcriptional regulator
I6I66_RS03180	COG1012	belongs to the aldehyde dehydrogenase family
I6I66_RS03190	COG3971	2-oxopent-4-enoate hydratase activity
I6I66_RS03220	COG1012	belongs to the aldehyde dehydrogenase family
I6I66_RS03295	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I66_RS03310	COG1715	Restriction endonuclease
I6I66_RS03320	COG3311	Transcriptional regulator
I6I66_RS03325	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6I66_RS03330	COG0495	leucyl-tRNA aminoacylation
I6I66_RS03355	COG0733	neurotransmitter:sodium symporter activity
I6I66_RS03365	COG0604	alcohol dehydrogenase
I6I66_RS03380	COG2197	response regulator
I6I66_RS03385	COG4585	Histidine kinase
I6I66_RS03390	COG0577	efflux transmembrane transporter activity
I6I66_RS03395	COG1136	(ABC) transporter
I6I66_RS03395	COG0577	efflux transmembrane transporter activity
I6I66_RS03415	COG4868	Belongs to the UPF0371 family
I6I66_RS03420	COG1054	Belongs to the UPF0176 family
I6I66_RS03435	COG1846	Transcriptional regulator
I6I66_RS03445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I66_RS03460	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I66_RS03465	COG0629	single-stranded DNA binding
I6I66_RS03470	COG0359	binds to the 23S rRNA
I6I66_RS03475	COG0305	Participates in initiation and elongation during chromosome replication
I6I66_RS03485	COG0477	Major facilitator Superfamily
I6I66_RS03500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I66_RS03505	COG1842	Phage shock protein A
I6I66_RS03520	COG1131	(ABC) transporter
I6I66_RS03545	COG0564	pseudouridine synthase activity
I6I66_RS03570	COG0706	membrane insertase activity
I6I66_RS03575	COG3764	Sortase (surface protein transpeptidase)
I6I66_RS03590	COG4585	Histidine kinase
I6I66_RS03590	COG2203	Gaf domain
I6I66_RS03595	COG2197	response regulator
I6I66_RS03620	COG2814	Major facilitator Superfamily
I6I66_RS03635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I66_RS03650	COG0584	glycerophosphoryl diester phosphodiesterase
I6I66_RS03660	COG1316	TRANSCRIPTIONal
I6I66_RS03675	COG0077	Prephenate dehydratase
I6I66_RS03695	COG2188	Transcriptional regulator
I6I66_RS03700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I66_RS03710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I66_RS03715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I66_RS03720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I66_RS03725	COG0561	phosphatase activity
I6I66_RS03755	COG2826	transposase and inactivated derivatives, IS30 family
I6I66_RS03760	COG1216	Glycosyl transferase, family 2
I6I66_RS03770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I66_RS03775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I66_RS03780	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I66_RS03785	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I66_RS03785	COG5479	isomerase activity
I6I66_RS03795	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6I66_RS03800	COG0318	PFAM AMP-dependent synthetase and ligase
I6I66_RS03805	COG3321	synthase
I6I66_RS03805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I66_RS03805	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I66_RS03810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I66_RS03845	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I66_RS03855	COG0438	transferase activity, transferring glycosyl groups
I6I66_RS03875	COG4981	capsule polysaccharide biosynthetic process
I6I66_RS03890	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I66_RS03900	COG1132	(ABC) transporter
I6I66_RS03950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I66_RS03975	COG0475	glutathione-regulated potassium exporter activity
I6I66_RS03975	COG0589	response to stress
I6I66_RS03980	COG0247	lactate metabolic process
I6I66_RS03980	COG2181	nitrate reductase activity
I6I66_RS04015	COG0175	sulfate reduction
I6I66_RS04055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I66_RS04065	COG1012	belongs to the aldehyde dehydrogenase family
I6I66_RS04070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I66_RS04075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I66_RS04080	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I66_RS04085	COG1120	ATPase activity
I6I66_RS04090	COG0443	Heat shock 70 kDa protein
I6I66_RS04105	COG0789	Transcriptional regulator
I6I66_RS04110	COG1012	belongs to the aldehyde dehydrogenase family
I6I66_RS04125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I66_RS04160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I66_RS04175	COG0191	fructose-bisphosphate aldolase activity
I6I66_RS04190	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I66_RS04195	COG0471	metal ion transport
I6I66_RS04200	COG4129	membrane
I6I66_RS04210	COG2826	transposase and inactivated derivatives, IS30 family
I6I66_RS04230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I66_RS04250	COG3711	transcriptional antiterminator
I6I66_RS04260	COG0280	phosphate acetyltransferase
I6I66_RS04265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I66_RS04275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I66_RS04290	COG1131	(ABC) transporter
I6I66_RS04300	COG2814	Major facilitator Superfamily
I6I66_RS04320	COG0242	peptide deformylase activity
I6I66_RS04340	COG1051	belongs to the nudix hydrolase family
I6I66_RS04360	COG0651	ATP synthesis coupled electron transport
I6I66_RS04365	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I66_RS04370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I66_RS04370	COG2111	Na H antiporter
I6I66_RS04380	COG1297	OPT oligopeptide transporter protein
I6I66_RS04395	COG2326	polyphosphate kinase activity
I6I66_RS04400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I66_RS04410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I66_RS04430	COG0577	efflux transmembrane transporter activity
I6I66_RS04430	COG1136	(ABC) transporter
I6I66_RS04450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I66_RS04455	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I66_RS04460	COG0037	tRNA processing
I6I66_RS04470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I66_RS04475	COG0302	gtp cyclohydrolase
I6I66_RS04490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I66_RS04510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I66_RS04525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I66_RS04540	COG2814	Major facilitator Superfamily
I6I66_RS04550	COG0542	response to heat
I6I66_RS04585	COG1194	a g-specific adenine glycosylase
I6I66_RS04600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I66_RS04615	COG2847	Copper chaperone PCu(A)C
I6I66_RS04640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I66_RS04645	COG1129	ABC transporter
I6I66_RS04665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I66_RS04670	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I66_RS04670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I66_RS04680	COG1609	Transcriptional regulator
I6I66_RS04685	COG1877	trehalose-phosphatase activity
I6I66_RS04695	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I66_RS04720	COG0477	Major facilitator Superfamily
I6I66_RS04725	COG0028	Belongs to the TPP enzyme family
I6I66_RS04740	COG0745	RESPONSE REGULATOR receiver
I6I66_RS04745	COG2205	protein histidine kinase activity
I6I66_RS04760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I66_RS04795	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I66_RS04800	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I66_RS04805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I66_RS04820	COG1272	protein, Hemolysin III
I6I66_RS04835	COG0183	Belongs to the thiolase family
I6I66_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
I6I66_RS04845	COG2030	dehydratase
I6I66_RS04865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I66_RS04890	COG1597	lipid kinase activity
I6I66_RS04900	COG0456	acetyltransferase
I6I66_RS04920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I66_RS04945	COG1937	Protein conserved in bacteria
I6I66_RS04980	COG1045	serine acetyltransferase
I6I66_RS04985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I66_RS04990	COG2197	response regulator
I6I66_RS04995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I66_RS05020	COG2239	Acts as a magnesium transporter
I6I66_RS05040	COG1136	(ABC) transporter
I6I66_RS05040	COG0577	efflux transmembrane transporter activity
I6I66_RS05045	COG1136	(ABC) transporter
I6I66_RS05045	COG0577	efflux transmembrane transporter activity
I6I66_RS05050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I66_RS05055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I66_RS05060	COG0033	Phosphoglucomutase
I6I66_RS05095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I66_RS05100	COG2814	Major facilitator Superfamily
I6I66_RS05105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I66_RS05120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I66_RS05125	COG2186	Transcriptional regulator
I6I66_RS05130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I66_RS05135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I66_RS05155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I66_RS05165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I66_RS05175	COG3191	aminopeptidase activity
I6I66_RS05190	COG1234	tRNA 3'-trailer cleavage
I6I66_RS05195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I66_RS05225	COG2233	PERMEase
I6I66_RS05230	COG1882	Formate acetyltransferase
I6I66_RS05235	COG1882	Formate acetyltransferase
I6I66_RS05240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I66_RS05285	COG1129	ABC transporter
I6I66_RS05310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I66_RS05315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I66_RS05320	COG1120	ATPase activity
I6I66_RS05335	COG1376	ErfK ybiS ycfS ynhG family protein
I6I66_RS05340	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I66_RS05350	COG2094	Belongs to the DNA glycosylase MPG family
I6I66_RS05365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I66_RS05370	COG1115	amino acid carrier protein
I6I66_RS05380	COG4221	oxidoreductase activity
I6I66_RS05400	COG0583	DNA-binding transcription factor activity
I6I66_RS05405	COG1276	copper resistance
I6I66_RS05450	COG0668	transmembrane transport
I6I66_RS05465	COG0747	negative chemotaxis
I6I66_RS05475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I66_RS05490	COG0300	oxidoreductase activity
I6I66_RS05495	COG2188	Transcriptional regulator
I6I66_RS05520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I66_RS05555	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I66_RS05560	COG0431	NADPH-dependent FMN reductase
I6I66_RS05570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I66_RS05575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I66_RS05580	COG1780	Probably involved in ribonucleotide reductase function
I6I66_RS05595	COG0740	serine-type endopeptidase activity
I6I66_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
I6I66_RS05605	COG2814	Major facilitator Superfamily
I6I66_RS05610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I66_RS05620	COG0039	L-malate dehydrogenase activity
I6I66_RS05630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I66_RS05640	COG0285	dihydrofolate synthase activity
I6I66_RS05650	COG0657	acetylesterase activity
I6I66_RS05660	COG0105	UTP biosynthetic process
I6I66_RS05665	COG0640	Transcriptional regulator
I6I66_RS05670	COG0798	PFAM Bile acid sodium symporter
I6I66_RS05680	COG1530	ribonuclease E activity
I6I66_RS05685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I66_RS05690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I66_RS05710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I66_RS05730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I66_RS05740	COG0406	alpha-ribazole phosphatase activity
I6I66_RS05745	COG1307	EDD domain protein, DegV family
I6I66_RS05785	COG0268	Binds directly to 16S ribosomal RNA
I6I66_RS05795	COG0481	GTPase activity
I6I66_RS05820	COG1473	amidohydrolase
I6I66_RS05840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I66_RS05850	COG4172	Belongs to the ABC transporter superfamily
I6I66_RS05865	COG0747	negative chemotaxis
I6I66_RS05870	COG2186	Transcriptional regulator
I6I66_RS05875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I66_RS05880	COG1114	Component of the transport system for branched-chain amino acids
I6I66_RS05890	COG1132	(ABC) transporter
I6I66_RS05900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I66_RS05905	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I66_RS05920	COG1022	Amp-dependent synthetase and ligase
I6I66_RS05930	COG1253	flavin adenine dinucleotide binding
I6I66_RS05935	COG1253	flavin adenine dinucleotide binding
I6I66_RS05950	COG1420	regulation of RNA biosynthetic process
I6I66_RS05970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I66_RS05985	COG1381	Involved in DNA repair and RecF pathway recombination
I6I66_RS05990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I66_RS06005	COG0423	glycine-tRNA ligase activity
I6I66_RS06030	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I66_RS06065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I66_RS06170	COG0756	dUTP diphosphatase activity
I6I66_RS06175	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6I66_RS06270	COG0305	Participates in initiation and elongation during chromosome replication
I6I66_RS06380	COG0739	heme binding
I6I66_RS06415	COG1134	teichoic acid transport
I6I66_RS06425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I66_RS06430	COG0438	transferase activity, transferring glycosyl groups
I6I66_RS06505	COG3311	Transcriptional regulator
I6I66_RS06520	COG1764	response to oxidative stress
I6I66_RS06550	COG2860	membrane
I6I66_RS06555	COG4166	transmembrane transport
I6I66_RS06560	COG0668	transmembrane transport
I6I66_RS06585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I66_RS06595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I66_RS06625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I66_RS06670	COG0174	glutamine synthetase
I6I66_RS06675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I66_RS06690	COG2271	Major facilitator Superfamily
I6I66_RS06695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I66_RS06740	COG1120	ATPase activity
I6I66_RS06755	COG0174	glutamine synthetase
I6I66_RS06770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I66_RS06775	COG0321	lipoyl(octanoyl) transferase activity
I6I66_RS06780	COG0509	glycine decarboxylation via glycine cleavage system
I6I66_RS06785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I66_RS06790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I66_RS06790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I66_RS06800	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I66_RS06810	COG1335	isochorismatase
I6I66_RS06815	COG2066	Belongs to the glutaminase family
I6I66_RS06825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I66_RS06830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I66_RS06860	COG1845	cytochrome c oxidase, subunit III
I6I66_RS06875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I66_RS06890	COG0438	transferase activity, transferring glycosyl groups
I6I66_RS06895	COG1940	carbohydrate kinase activity
I6I66_RS06915	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I66_RS06935	COG0142	geranyltranstransferase activity
I6I66_RS06975	COG0275	rRNA processing
I6I66_RS06985	COG0768	penicillin binding
I6I66_RS06990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I66_RS07000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I66_RS07015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I66_RS07020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I66_RS07025	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I66_RS07030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I66_RS07035	COG1496	oxidoreductase activity
I6I66_RS07040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I66_RS07045	COG1799	cell septum assembly
I6I66_RS07055	COG3599	regulation of cell shape
I6I66_RS07070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I66_RS07090	COG0252	asparaginase activity
I6I66_RS07135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I66_RS07150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I66_RS07155	COG1739	Uncharacterized protein family UPF0029
I6I66_RS07180	COG2176	DNA-directed DNA polymerase activity
I6I66_RS07210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I66_RS07215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I66_RS07220	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I66_RS07235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I66_RS07250	COG0107	imidazoleglycerol-phosphate synthase activity
I6I66_RS07270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I66_RS07275	COG0469	pyruvate kinase activity
I6I66_RS07280	COG0058	SHG alpha-glucan phosphorylase activity
I6I66_RS07295	COG1929	Belongs to the glycerate kinase type-1 family
I6I66_RS07300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I66_RS07315	COG0571	ribonuclease III activity
I6I66_RS07320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I66_RS07325	COG1115	amino acid carrier protein
I6I66_RS07330	COG1254	Belongs to the acylphosphatase family
I6I66_RS07345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I66_RS07345	COG2111	Na H antiporter
I6I66_RS07350	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I66_RS07355	COG0651	ATP synthesis coupled electron transport
I6I66_RS07380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I66_RS07390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I66_RS07390	COG2755	lipolytic protein G-D-S-L family
I6I66_RS07395	COG0228	four-way junction DNA binding
I6I66_RS07415	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I66_RS07445	COG2022	thiamine diphosphate biosynthetic process
I6I66_RS07460	COG0352	thiamine-phosphate diphosphorylase activity
I6I66_RS07475	COG0681	Belongs to the peptidase S26 family
I6I66_RS07485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I66_RS07495	COG0792	nuclease activity
I6I66_RS07510	COG4974	Belongs to the 'phage' integrase family
I6I66_RS07525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I66_RS07530	COG0528	UMP kinase activity
I6I66_RS07535	COG0233	cytoplasmic translational termination
I6I66_RS07540	COG0575	Belongs to the CDS family
I6I66_RS07550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I66_RS07570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I66_RS07580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I66_RS07585	COG0768	penicillin binding
I6I66_RS07625	COG0579	oxidoreductase
I6I66_RS07630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I66_RS07650	COG3022	response to hydroperoxide
I6I66_RS07655	COG0442	prolyl-tRNA aminoacylation
I6I66_RS07665	COG0779	Required for maturation of 30S ribosomal subunits
I6I66_RS07680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I66_RS07685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I66_RS07690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I66_RS07695	COG0534	Mate efflux family protein
I6I66_RS07700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I66_RS07705	COG2977	Belongs to the P-Pant transferase superfamily
I6I66_RS07710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I66_RS07725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I66_RS07730	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I66_RS07755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I66_RS07760	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6I66_RS07765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I66_RS07770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I66_RS07780	COG1674	ftsk spoiiie
I6I66_RS07795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I66_RS07805	COG1396	sequence-specific DNA binding
I6I66_RS07810	COG1842	Phage shock protein A
I6I66_RS07815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I66_RS07820	COG1122	ATPase activity
I6I66_RS07825	COG1268	BioY protein
I6I66_RS07835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I66_RS07840	COG2137	regulation of response to DNA damage stimulus
I6I66_RS07855	COG1902	pentaerythritol trinitrate reductase activity
I6I66_RS07865	COG1196	nuclear chromosome segregation
I6I66_RS07880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I66_RS07895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I66_RS07900	COG2233	PERMEase
I6I66_RS07910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I66_RS07915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I66_RS07915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I66_RS07915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I66_RS07925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I66_RS07930	COG1349	DNA-binding transcription factor activity
I6I66_RS07940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I66_RS07945	COG1643	Atp-dependent helicase
I6I66_RS07960	COG0450	alkyl hydroperoxide reductase
I6I66_RS07965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I66_RS08000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I66_RS08005	COG1321	iron dependent repressor
I6I66_RS08035	COG1061	Type III restriction enzyme res subunit
I6I66_RS08050	COG2376	Dihydroxyacetone kinase
I6I66_RS08055	COG1461	Dihydroxyacetone kinase
I6I66_RS08100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I66_RS08105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I66_RS08110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I66_RS08120	COG3253	May function as heme-dependent peroxidase
I6I66_RS08125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I66_RS08200	COG2837	iron assimilation
I6I66_RS08205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I66_RS08215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I66_RS08220	COG1560	Kdo2-lipid A biosynthetic process
I6I66_RS08225	COG0438	transferase activity, transferring glycosyl groups
I6I66_RS08245	COG1946	Acyl-CoA thioesterase
I6I66_RS08250	COG0217	transcriptional regulatory protein
I6I66_RS08260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I66_RS08265	COG0632	four-way junction helicase activity
I6I66_RS08270	COG2255	four-way junction helicase activity
I6I66_RS08280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I66_RS08285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I66_RS08290	COG0747	negative chemotaxis
I6I66_RS08300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I66_RS08305	COG0737	Belongs to the 5'-nucleotidase family
I6I66_RS08330	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I66_RS08335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I66_RS08340	COG0124	histidyl-tRNA synthetase
I6I66_RS08345	COG1760	l-serine dehydratase
I6I66_RS08350	COG0431	NADPH-dependent FMN reductase
I6I66_RS08375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I66_RS08395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I66_RS08405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I66_RS08415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I66_RS08420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I66_RS08430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I66_RS08435	COG0006	proline dipeptidase activity
I6I66_RS08440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I66_RS08445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I66_RS08450	COG1126	abc transporter atp-binding protein
I6I66_RS08455	COG0765	amino acid transport
I6I66_RS08460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I66_RS08490	COG2226	methyltransferase
I6I66_RS08495	COG0539	negative regulation of cytoplasmic translation
I6I66_RS08500	COG0237	dephospho-CoA kinase activity
I6I66_RS08535	COG3973	AAA domain
I6I66_RS08565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I66_RS08570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I66_RS08580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I66_RS08590	COG0072	phenylalanine-tRNA ligase activity
I6I66_RS08590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I66_RS08600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I66_RS08605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I66_RS08615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I66_RS08620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I66_RS08625	COG1438	arginine binding
I6I66_RS08630	COG0137	argininosuccinate synthase activity
I6I66_RS08635	COG0165	Argininosuccinate lyase
I6I66_RS08655	COG2304	oxidoreductase activity
I6I66_RS08665	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I66_RS08695	COG2826	transposase and inactivated derivatives, IS30 family
I6I66_RS08720	COG0647	UMP catabolic process
I6I66_RS08735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I66_RS08755	COG0494	nUDIX hydrolase
I6I66_RS08760	COG4974	Belongs to the 'phage' integrase family
I6I66_RS08780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I66_RS08790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I66_RS08795	COG1160	GTP binding
I6I66_RS08805	COG2197	response regulator
I6I66_RS08820	COG1131	(ABC) transporter
I6I66_RS08860	COG3012	SEC-C Motif Domain Protein
I6I66_RS08870	COG0653	protein targeting
I6I66_RS08875	COG1716	ATPase activity
I6I66_RS08905	COG0513	Belongs to the DEAD box helicase family
I6I66_RS08920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I66_RS08930	COG0598	Magnesium transport protein CorA
I6I66_RS08940	COG0352	thiamine-phosphate diphosphorylase activity
I6I66_RS08940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I66_RS08940	COG0351	phosphomethylpyrimidine kinase
I6I66_RS08955	COG0584	glycerophosphoryl diester phosphodiesterase
I6I66_RS08960	COG1175	transmembrane transport
I6I66_RS08965	COG0395	ABC-type sugar transport system, permease component
I6I66_RS08975	COG3842	ATPase activity
I6I66_RS08990	COG0477	Major facilitator Superfamily
I6I66_RS09040	COG3842	ATPase activity
I6I66_RS09045	COG0463	Glycosyl transferase, family 2
I6I66_RS09065	COG0300	oxidoreductase activity
I6I66_RS09085	COG0805	protein transport
I6I66_RS09090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I66_RS09105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6I66_RS09115	COG4122	O-methyltransferase activity
I6I66_RS09120	COG1222	aaa ATPase
I6I66_RS09130	COG1362	aminopeptidase activity
I6I66_RS09145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I66_RS09150	COG1027	Aspartate ammonia-lyase
I6I66_RS09155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I66_RS09160	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I66_RS09165	COG0546	phosphoglycolate phosphatase activity
I6I66_RS09175	COG0215	cysteine-tRNA ligase activity
I6I66_RS09180	COG1968	undecaprenyl-diphosphatase activity
I6I66_RS09190	COG0167	dihydroorotate dehydrogenase activity
I6I66_RS09200	COG1881	PFAM PEBP family protein
I6I66_RS09240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I66_RS09245	COG3883	PFAM NLP P60 protein
I6I66_RS09245	COG0791	NLP P60 protein
I6I66_RS09260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I66_RS09290	COG3830	Belongs to the UPF0237 family
I6I66_RS09295	COG2848	UPF0210 protein
I6I66_RS09315	COG0488	(ABC) transporter
I6I66_RS09320	COG2826	transposase and inactivated derivatives, IS30 family
I6I66_RS09330	COG0822	iron-sulfur transferase activity
I6I66_RS09340	COG0396	ATPase activity
I6I66_RS09395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I66_RS09415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I66_RS09425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I66_RS09430	COG1481	regulation of sporulation
I6I66_RS09440	COG1660	Displays ATPase and GTPase activities
I6I66_RS09445	COG0322	excinuclease ABC activity
I6I66_RS09455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I66_RS09485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I66_RS09490	COG0242	peptide deformylase activity
I6I66_RS09500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I66_RS09510	COG1758	RNA polymerase activity
I6I66_RS09525	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I66_RS09530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I66_RS09535	COG0505	Belongs to the CarA family
I6I66_RS09540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I66_RS09545	COG0540	Belongs to the ATCase OTCase family
I6I66_RS09555	COG1090	epimerase
I6I66_RS09580	COG2326	polyphosphate kinase activity
I6I66_RS09590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I66_RS09595	COG0742	ribosomal rna small subunit methyltransferase
I6I66_RS09600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I66_RS09605	COG1461	Dihydroxyacetone kinase
I6I66_RS09610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I66_RS09615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I66_RS09625	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I66_RS09630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I66_RS09635	COG0494	nUDIX hydrolase
I6I66_RS09635	COG0406	alpha-ribazole phosphatase activity
I6I66_RS09645	COG0066	3-isopropylmalate dehydratase activity
I6I66_RS09650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I66_RS09775	COG1121	(ABC) transporter
I6I66_RS09780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I66_RS09810	COG0473	3-isopropylmalate dehydrogenase activity
I6I66_RS09830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I66_RS09840	COG0028	Belongs to the TPP enzyme family
I6I66_RS09850	COG0129	dihydroxy-acid dehydratase activity
I6I66_RS09880	COG0583	DNA-binding transcription factor activity
I6I66_RS09890	COG3949	Membrane
I6I66_RS09895	COG1064	alcohol dehydrogenase
I6I66_RS09905	COG0569	domain protein
I6I66_RS09905	COG2985	domain, Protein
I6I66_RS09910	COG0205	6-phosphofructokinase activity
I6I66_RS09935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I66_RS09955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I66_RS10015	COG0482	sulfurtransferase activity
I6I66_RS10045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I66_RS10065	COG1119	ATPase activity
I6I66_RS10070	COG0366	Alpha amylase catalytic
I6I66_RS10080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I66_RS10085	COG4166	transmembrane transport
I6I66_RS10100	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6I66_RS10110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I66_RS10115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I66_RS10120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I66_RS10125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I66_RS10130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I66_RS10135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I66_RS10140	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I66_RS10145	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I66_RS10155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I66_RS10170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I66_RS10195	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I66_RS10220	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I66_RS10235	COG0083	homoserine kinase activity
I6I66_RS10240	COG0460	homoserine dehydrogenase
I6I66_RS10245	COG0019	diaminopimelate decarboxylase activity
I6I66_RS10250	COG0018	arginyl-trna synthetase
I6I66_RS10255	COG1620	l-lactate permease
I6I66_RS10260	COG0247	lactate metabolic process
I6I66_RS10265	COG1139	Iron-sulfur cluster binding protein
I6I66_RS10270	COG1556	Lactate utilization protein
I6I66_RS10310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I66_RS10320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I66_RS10325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I66_RS10350	COG1228	amidohydrolase
I6I66_RS10355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I66_RS10360	COG2826	transposase and inactivated derivatives, IS30 family
I6I66_RS10370	COG2986	histidine ammonia-lyase
I6I66_RS10380	COG3314	Sporulation integral membrane protein YlbJ
I6I66_RS10390	COG0010	Belongs to the arginase family
I6I66_RS10395	COG0494	nUDIX hydrolase
I6I66_RS10410	COG2814	Major facilitator Superfamily
I6I66_RS10430	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I66_RS10440	COG0567	Dehydrogenase, E1 component
I6I66_RS10440	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I66_RS10475	COG1595	DNA-templated transcription, initiation
I6I66_RS10485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I66_RS10490	COG0297	glycogen (starch) synthase activity
I6I66_RS10515	COG0463	Glycosyl transferase, family 2
I6I66_RS10525	COG1611	Belongs to the LOG family
I6I66_RS10530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I66_RS10535	COG1113	amino acid transport
I6I66_RS10545	COG1113	amino acid transport
I6I66_RS10555	COG1476	TRANSCRIPTIONal
I6I66_RS10600	COG1217	gtp-binding protein TYPA
I6I66_RS10615	COG2354	Protein conserved in bacteria
I6I66_RS10620	COG0428	transporter
I6I66_RS10660	COG0437	4 iron, 4 sulfur cluster binding
I6I66_RS10665	COG0243	molybdopterin cofactor binding
I6I66_RS10665	COG3383	formate dehydrogenase (NAD+) activity
I6I66_RS10670	COG3383	formate dehydrogenase (NAD+) activity
I6I66_RS10670	COG0243	molybdopterin cofactor binding
I6I66_RS10675	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I6I66_RS10685	COG1823	symporter activity
I6I66_RS10720	COG0789	Transcriptional regulator
I6I66_RS10730	COG2814	Major facilitator Superfamily
I6I66_RS10745	COG1012	belongs to the aldehyde dehydrogenase family
I6I66_RS10755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I66_RS10770	COG0012	GTP binding
I6I66_RS10780	COG1322	Protein conserved in bacteria
I6I66_RS10795	COG1570	exodeoxyribonuclease VII activity
I6I66_RS10800	COG1722	exodeoxyribonuclease VII activity
I6I66_RS10815	COG1494	fructose-1,6-bisphosphatase
I6I66_RS10820	COG0114	fumarate hydratase activity
I6I66_RS10845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I66_RS10870	COG1072	(Pantothenic acid kinase))
I6I66_RS10885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I66_RS10940	COG0148	phosphopyruvate hydratase activity
I6I66_RS10955	COG3956	TIGRFAM MazG family protein
I6I66_RS10960	COG0531	amino acid
I6I66_RS10985	COG2860	membrane
I6I66_RS10990	COG2826	transposase and inactivated derivatives, IS30 family
I6I66_RS11005	COG2132	Multicopper oxidase
I6I66_RS11015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I66_RS11020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I66_RS11030	COG0193	aminoacyl-tRNA hydrolase activity
I6I66_RS11035	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I66_RS11045	COG2326	polyphosphate kinase activity
I6I66_RS11055	COG2070	2-Nitropropane dioxygenase
I6I66_RS11060	COG0193	aminoacyl-tRNA hydrolase activity
I6I66_RS11070	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I66_RS11075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I66_RS11080	COG2610	gluconate transmembrane transporter activity
I6I66_RS11105	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I66_RS11115	COG1960	acyl-CoA dehydrogenase activity
I6I66_RS11125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I66_RS11140	COG1024	Enoyl-CoA hydratase
I6I66_RS11145	COG0183	Belongs to the thiolase family
I6I66_RS11150	COG0569	domain protein
I6I66_RS11150	COG2985	domain, Protein
I6I66_RS11180	COG0438	transferase activity, transferring glycosyl groups
I6I66_RS11195	COG0561	phosphatase activity
I6I66_RS11205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I66_RS11205	COG2755	lipolytic protein G-D-S-L family
I6I66_RS11225	COG0488	(ABC) transporter
I6I66_RS11245	COG3583	domain protein
I6I66_RS11250	COG0084	hydrolase, TatD family'
I6I66_RS11270	COG3549	Plasmid maintenance system killer
I6I66_RS11285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I66_RS11295	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6I66_RS11315	COG0519	Catalyzes the synthesis of GMP from XMP
I6I66_RS11335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I66_RS11350	COG1970	mechanosensitive ion channel activity
I6I66_RS11360	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I66_RS11360	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I66_RS11365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I66_RS11370	COG2205	protein histidine kinase activity
I6I66_RS11385	COG0254	rRNA binding
I6I66_RS11390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I66_RS11395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I66_RS11400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I66_RS11425	COG0515	serine threonine protein kinase
I6I66_RS11450	COG0138	bifunctional purine biosynthesis protein purh
I6I66_RS11465	COG0739	heme binding
I6I66_RS11495	COG1605	Chorismate mutase
I6I66_RS11515	COG3304	Inner membrane component domain
I6I66_RS11520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I66_RS11530	COG1201	RNA secondary structure unwinding
I6I66_RS11535	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I66_RS11540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I66_RS11550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I66_RS11590	COG1061	Type III restriction enzyme res subunit
I6I66_RS11655	COG1765	OsmC-like protein
I6I66_RS11665	COG3757	hydrolase, family 25
I6I66_RS11675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I66_RS11690	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I66_RS11715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I66_RS11720	COG2252	PERMEase
I6I66_RS11745	COG1652	LysM domain
I6I66_RS11770	COG1061	Type III restriction enzyme res subunit
I6I66_RS11825	COG4607	ABC-type enterochelin transport system periplasmic component
I6I66_RS11835	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6I66_RS11850	COG0814	amino acid
I6I66_RS11865	COG2177	Part of the ABC transporter FtsEX involved in
I6I66_RS11870	COG2884	Cell division ATP-binding protein ftsE
I6I66_RS11875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I66_RS11880	COG0483	inositol monophosphate 1-phosphatase activity
I6I66_RS11885	COG0483	inositol monophosphate 1-phosphatase activity
I6I66_RS11910	COG4762	Protein conserved in bacteria
I6I66_RS11925	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I66_RS11950	COG0659	secondary active sulfate transmembrane transporter activity
I6I66_RS11980	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I66_RS12005	COG2816	NAD+ diphosphatase activity
I6I66_RS12010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I66_RS12040	COG0513	Belongs to the DEAD box helicase family
I6I66_RS12060	COG5662	AntiSigma factor
I6I66_RS12070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I66_RS12075	COG2135	peptidase activity
I6I66_RS12080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I66_RS12085	COG1162	GTPase activity
I6I66_RS12090	COG2390	Transcriptional regulator
I6I66_RS12095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I66_RS12100	COG0738	Major facilitator superfamily
I6I66_RS12155	COG0653	protein targeting
I6I66_RS12160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I66_RS12170	COG5401	PFAM Sporulation and spore germination
I6I66_RS12175	COG5002	protein histidine kinase activity
I6I66_RS12180	COG0745	RESPONSE REGULATOR receiver
I6I66_RS12200	COG1482	cell wall glycoprotein biosynthetic process
I6I66_RS12210	COG1648	precorrin-2 dehydrogenase activity
I6I66_RS12210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I66_RS12215	COG0730	response to heat
I6I66_RS12230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I66_RS12270	COG1316	TRANSCRIPTIONal
I6I66_RS12295	COG0028	Belongs to the TPP enzyme family
I6I66_RS12300	COG0814	amino acid
I6I66_RS12310	COG1012	belongs to the aldehyde dehydrogenase family
I6I66_RS12350	COG2072	flavoprotein involved in K transport
I6I66_RS12355	COG0657	acetylesterase activity
I6I66_RS12380	COG3835	regulator
I6I66_RS12395	COG1960	acyl-CoA dehydrogenase activity
I6I66_RS12410	COG1024	Enoyl-CoA hydratase
I6I66_RS12420	COG2315	Protein conserved in bacteria
I6I66_RS12435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I66_RS12445	COG3835	regulator
I6I66_RS12470	COG2610	gluconate transmembrane transporter activity
I6I66_RS12475	COG3265	gluconokinase activity
I6I66_RS12485	COG2040	homocysteine
I6I66_RS12490	COG0517	IMP dehydrogenase activity
I6I66_RS12490	COG4175	Glycine betaine
I6I66_RS12505	COG2113	Glycine betaine
I6I66_RS12510	COG2340	Cysteine-rich secretory protein family
I6I66_RS12520	COG1401	restriction endodeoxyribonuclease activity
I6I66_RS12535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I66_RS12540	COG0737	Belongs to the 5'-nucleotidase family
I6I66_RS12550	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6I66_RS12560	COG1484	DNA-dependent DNA replication
I6I66_RS12635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I66_RS12640	COG1984	allophanate hydrolase subunit 2
I6I66_RS12645	COG4770	biotin carboxylase activity
I6I66_RS12655	COG4336	lyase activity
I6I66_RS12660	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I66_RS12665	COG0183	Belongs to the thiolase family
I6I66_RS12670	COG1024	Enoyl-CoA hydratase
I6I66_RS12670	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I66_RS12675	COG1192	Involved in chromosome partitioning
I6I66_RS12685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I66_RS12725	COG1129	ABC transporter
I6I66_RS12730	COG2375	cellular response to nickel ion
I6I66_RS12730	COG1132	(ABC) transporter
I6I66_RS12735	COG1132	(ABC) transporter
I6I66_RS12770	COG3311	Transcriptional regulator
I6I66_RS12775	COG1569	PIN domain
I6I66_RS12780	COG2963	transposase activity