locus-tag	class	description
H924_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H924_RS00010	COG0592	DNA-directed DNA polymerase activity
H924_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H924_RS00025	COG0187	DNA topoisomerase II activity
H924_RS00085	COG2814	Major facilitator Superfamily
H924_RS00090	COG1846	Transcriptional regulator
H924_RS00115	COG0803	Belongs to the bacterial solute-binding protein 9 family
H924_RS00120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H924_RS00125	COG1121	(ABC) transporter
H924_RS00135	COG1172	Belongs to the binding-protein-dependent transport system permease family
H924_RS00150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H924_RS00160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H924_RS00165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H924_RS00180	COG0493	'glutamate synthase
H924_RS00190	COG1953	Uracil, thiamine, allantoin
H924_RS00205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H924_RS00225	COG2815	serine threonine protein kinase
H924_RS00225	COG0515	serine threonine protein kinase
H924_RS00230	COG0515	serine threonine protein kinase
H924_RS00235	COG0768	penicillin binding
H924_RS00255	COG1716	ATPase activity
H924_RS00285	COG3321	synthase
H924_RS00285	COG0604	alcohol dehydrogenase
H924_RS00290	COG1937	Protein conserved in bacteria
H924_RS00295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H924_RS00300	COG0019	diaminopimelate decarboxylase activity
H924_RS00315	COG2409	Drug exporters of the RND superfamily
H924_RS00325	COG0415	Belongs to the DNA photolyase family
H924_RS00330	COG0702	epimerase
H924_RS00335	COG0142	geranyltranstransferase activity
H924_RS00345	COG1233	COG1233 Phytoene dehydrogenase and related
H924_RS00390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H924_RS00410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H924_RS00415	COG2851	Citrate transporter
H924_RS00420	COG3290	protein histidine kinase activity
H924_RS00425	COG4565	transcriptional regulatory protein
H924_RS00440	COG1012	belongs to the aldehyde dehydrogenase family
H924_RS00460	COG1028	Short-chain dehydrogenase reductase Sdr
H924_RS00535	COG0402	S-adenosylhomocysteine deaminase activity
H924_RS00550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H924_RS00555	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H924_RS00570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H924_RS00580	COG2814	Major facilitator Superfamily
H924_RS00600	COG2826	transposase and inactivated derivatives, IS30 family
H924_RS00620	COG1660	Displays ATPase and GTPase activities
H924_RS00645	COG1012	belongs to the aldehyde dehydrogenase family
H924_RS00650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H924_RS00660	COG2149	membrane
H924_RS00670	COG0346	lactoylglutathione lyase activity
H924_RS00680	COG1401	restriction endodeoxyribonuclease activity
H924_RS00690	COG2814	Major facilitator Superfamily
H924_RS00700	COG1070	Carbohydrate kinase
H924_RS00715	COG2094	Belongs to the DNA glycosylase MPG family
H924_RS00720	COG0778	Nitroreductase
H924_RS00730	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H924_RS00735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H924_RS00775	COG2860	membrane
H924_RS00780	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H924_RS00800	COG3180	Ammonia monooxygenase
H924_RS00810	COG0730	response to heat
H924_RS00820	COG1643	Atp-dependent helicase
H924_RS00825	COG0110	maltose O-acetyltransferase activity
H924_RS00835	COG1280	lysine exporter protein (LysE YggA)
H924_RS00840	COG2501	S4 domain
H924_RS00870	COG3590	peptidase
H924_RS00885	COG0070	glutamate synthase
H924_RS00885	COG0069	glutamate synthase activity
H924_RS00885	COG0067	glutamate synthase
H924_RS00910	COG1028	Short-chain dehydrogenase reductase Sdr
H924_RS00915	COG0277	FAD linked oxidase domain protein
H924_RS00945	COG1216	Glycosyl transferase, family 2
H924_RS00965	COG0604	alcohol dehydrogenase
H924_RS00980	COG1950	PFAM Membrane protein of
H924_RS01005	COG0287	Prephenate dehydrogenase
H924_RS01035	COG2409	Drug exporters of the RND superfamily
H924_RS01040	COG0343	queuine tRNA-ribosyltransferase activity
H924_RS01060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H924_RS01080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H924_RS01095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H924_RS01105	COG3442	glutamine amidotransferase
H924_RS01110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H924_RS01145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H924_RS01150	COG0697	spore germination
H924_RS01155	COG0527	aspartate kinase activity
H924_RS01180	COG0798	PFAM Bile acid sodium symporter
H924_RS01185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H924_RS01190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H924_RS01210	COG0651	ATP synthesis coupled electron transport
H924_RS01215	COG1006	Multisubunit Na H antiporter MnhC subunit
H924_RS01220	COG2111	Na H antiporter
H924_RS01220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H924_RS01230	COG0745	RESPONSE REGULATOR receiver
H924_RS01235	COG5002	protein histidine kinase activity
H924_RS01235	COG3850	Histidine kinase
H924_RS01255	COG1408	metallophosphoesterase
H924_RS01280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H924_RS01285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H924_RS01365	COG1205	dead DEAH box helicase
H924_RS01365	COG1111	helicase
H924_RS01370	COG1278	Cold shock
H924_RS01375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H924_RS01375	COG1754	DNA topoisomerase type I activity
H924_RS01400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H924_RS01460	COG0737	Belongs to the 5'-nucleotidase family
H924_RS01465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H924_RS01465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H924_RS01485	COG0693	protein deglycase activity
H924_RS01495	COG1064	alcohol dehydrogenase
H924_RS01525	COG1088	dTDP-glucose 4,6-dehydratase activity
H924_RS01535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H924_RS01555	COG1505	serine-type exopeptidase activity
H924_RS01580	COG1181	Belongs to the D-alanine--D-alanine ligase family
H924_RS01585	COG0546	phosphoglycolate phosphatase activity
H924_RS01595	COG0489	protein tyrosine kinase activity
H924_RS01610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H924_RS01615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H924_RS01640	COG2244	polysaccharide biosynthetic process
H924_RS01645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H924_RS01650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H924_RS01655	COG1215	transferase activity, transferring glycosyl groups
H924_RS01665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H924_RS01670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H924_RS01675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H924_RS01685	COG3800	Transcriptional regulator
H924_RS01685	COG1396	sequence-specific DNA binding
H924_RS01695	COG1053	succinate dehydrogenase
H924_RS01700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H924_RS01715	COG2733	membrane
H924_RS01735	COG1309	transcriptional regulator
H924_RS01750	COG0788	formyltetrahydrofolate deformylase activity
H924_RS01755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H924_RS01765	COG1937	Protein conserved in bacteria
H924_RS01790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H924_RS01800	COG0318	PFAM AMP-dependent synthetase and ligase
H924_RS01815	COG5002	protein histidine kinase activity
H924_RS01820	COG0745	RESPONSE REGULATOR receiver
H924_RS01830	COG0577	efflux transmembrane transporter activity
H924_RS01850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H924_RS01885	COG0693	protein deglycase activity
H924_RS01890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H924_RS01900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H924_RS01900	COG1648	precorrin-2 dehydrogenase activity
H924_RS01910	COG0113	porphobilinogen synthase activity
H924_RS01925	COG2217	Heavy metal translocating P-type atpase
H924_RS01930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H924_RS01945	COG0406	alpha-ribazole phosphatase activity
H924_RS01955	COG0785	Cytochrome C biogenesis protein
H924_RS01965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H924_RS02020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H924_RS02025	COG2154	pterin-4-alpha-carbinolamine dehydratase
H924_RS02030	COG3340	Belongs to the peptidase S51 family
H924_RS02035	COG4948	Mandelate Racemase Muconate Lactonizing
H924_RS02050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H924_RS02050	COG0438	transferase activity, transferring glycosyl groups
H924_RS02055	COG1113	amino acid transport
H924_RS02070	COG0142	geranyltranstransferase activity
H924_RS02100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H924_RS02105	COG0250	Participates in transcription elongation, termination and antitermination
H924_RS02110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H924_RS02175	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
H924_RS02220	COG1063	alcohol dehydrogenase
H924_RS02240	COG2608	mercury ion transmembrane transporter activity
H924_RS02295	COG2217	Heavy metal translocating P-type atpase
H924_RS02305	COG2205	protein histidine kinase activity
H924_RS02310	COG0745	RESPONSE REGULATOR receiver
H924_RS02320	COG2132	Multicopper oxidase
H924_RS02345	COG0300	oxidoreductase activity
H924_RS02395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H924_RS02410	COG0085	RNA polymerase activity
H924_RS02415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H924_RS02435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H924_RS02460	COG1120	ATPase activity
H924_RS02465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H924_RS02470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H924_RS02480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H924_RS02495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H924_RS02555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H924_RS02570	COG3845	ABC transporter
H924_RS02605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H924_RS02615	COG1841	ribosomal large subunit assembly
H924_RS02625	COG0201	protein transport
H924_RS02655	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H924_RS02660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H924_RS02670	COG0203	ribosomal protein L17
H924_RS02680	COG0101	tRNA pseudouridine synthase activity
H924_RS02700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H924_RS02710	COG1404	Belongs to the peptidase S8 family
H924_RS02720	COG1674	ftsk spoiiie
H924_RS02755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H924_RS02770	COG2801	Transposase and inactivated derivatives
H924_RS02790	COG0277	FAD linked oxidase domain protein
H924_RS02800	COG2801	Transposase and inactivated derivatives
H924_RS02860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H924_RS02870	COG0569	domain protein
H924_RS02870	COG2985	domain, Protein
H924_RS02885	COG0456	acetyltransferase
H924_RS02895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H924_RS02895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H924_RS02940	COG0516	GMP reductase activity
H924_RS02945	COG2610	gluconate transmembrane transporter activity
H924_RS02990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H924_RS03010	COG1136	(ABC) transporter
H924_RS03010	COG0577	efflux transmembrane transporter activity
H924_RS03015	COG2011	ABC-type metal ion transport system permease component
H924_RS03020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H924_RS03030	COG0587	DNA-directed DNA polymerase activity
H924_RS03045	COG1321	iron dependent repressor
H924_RS03055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H924_RS03065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H924_RS03085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H924_RS03090	COG2873	o-acetylhomoserine
H924_RS03095	COG1966	Carbon starvation protein
H924_RS03110	COG2838	Isocitrate dehydrogenase
H924_RS03125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H924_RS03130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H924_RS03140	COG2814	Major facilitator Superfamily
H924_RS03150	COG2860	membrane
H924_RS03160	COG0180	Tryptophanyl-tRNA synthetase
H924_RS03165	COG1295	ribonuclease BN
H924_RS03175	COG1686	Belongs to the peptidase S11 family
H924_RS03200	COG0791	NLP P60 protein
H924_RS03220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H924_RS03225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H924_RS03225	COG1473	amidohydrolase
H924_RS03245	COG0523	cobalamin synthesis protein
H924_RS03255	COG4770	biotin carboxylase activity
H924_RS03260	COG2897	thiosulfate sulfurtransferase activity
H924_RS03285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H924_RS03290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H924_RS03330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H924_RS03365	COG3842	ATPase activity
H924_RS03375	COG1316	TRANSCRIPTIONal
H924_RS03415	COG1482	cell wall glycoprotein biosynthetic process
H924_RS03445	COG0745	RESPONSE REGULATOR receiver
H924_RS03450	COG5002	protein histidine kinase activity
H924_RS03455	COG5401	PFAM Sporulation and spore germination
H924_RS03465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H924_RS03470	COG0653	protein targeting
H924_RS03480	COG1011	Hydrolase
H924_RS03495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H924_RS03530	COG0513	Belongs to the DEAD box helicase family
H924_RS03560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H924_RS03565	COG2816	NAD+ diphosphatase activity
H924_RS03590	COG3480	Lon protease (S16) C-terminal proteolytic domain
H924_RS03610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H924_RS03615	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H924_RS03620	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H924_RS03635	COG0483	inositol monophosphate 1-phosphatase activity
H924_RS03640	COG0483	inositol monophosphate 1-phosphatase activity
H924_RS03650	COG2884	Cell division ATP-binding protein ftsE
H924_RS03655	COG2177	Part of the ABC transporter FtsEX involved in
H924_RS03755	COG0741	lytic transglycosylase activity
H924_RS03915	COG4974	Belongs to the 'phage' integrase family
H924_RS03975	COG1061	Type III restriction enzyme res subunit
H924_RS03990	COG1652	LysM domain
H924_RS04020	COG2252	PERMEase
H924_RS04025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H924_RS04045	COG0372	Belongs to the citrate synthase family
H924_RS04050	COG0545	Peptidyl-prolyl cis-trans isomerase
H924_RS04065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H924_RS04075	COG3757	hydrolase, family 25
H924_RS04080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H924_RS04080	COG3321	synthase
H924_RS04080	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H924_RS04095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H924_RS04110	COG1218	3'(2'),5'-bisphosphate nucleotidase
H924_RS04115	COG1201	RNA secondary structure unwinding
H924_RS04120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H924_RS04125	COG3304	Inner membrane component domain
H924_RS04130	COG0586	Pfam SNARE associated Golgi protein
H924_RS04145	COG0166	Belongs to the GPI family
H924_RS04155	COG1605	Chorismate mutase
H924_RS04165	COG0739	heme binding
H924_RS04180	COG0138	bifunctional purine biosynthesis protein purh
H924_RS04190	COG1309	transcriptional regulator
H924_RS04205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H924_RS04210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H924_RS04230	COG0745	RESPONSE REGULATOR receiver
H924_RS04240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H924_RS04250	COG1970	mechanosensitive ion channel activity
H924_RS04265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H924_RS04300	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
H924_RS04310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H924_RS04320	COG0514	ATP-dependent DNA helicase (RecQ)
H924_RS04330	COG0084	hydrolase, TatD family'
H924_RS04335	COG3583	domain protein
H924_RS04340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H924_RS04350	COG0488	(ABC) transporter
H924_RS04355	COG1388	LysM domain
H924_RS04360	COG2217	Heavy metal translocating P-type atpase
H924_RS04375	COG2326	polyphosphate kinase activity
H924_RS04380	COG0561	phosphatase activity
H924_RS04410	COG2409	Drug exporters of the RND superfamily
H924_RS04415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H924_RS04430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H924_RS04435	COG0831	urea catabolic process
H924_RS04440	COG0832	Belongs to the urease beta subunit family
H924_RS04445	COG0804	urea catabolic process
H924_RS04450	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H924_RS04455	COG0830	nickel cation binding
H924_RS04465	COG0829	nickel cation binding
H924_RS04485	COG1129	ABC transporter
H924_RS04495	COG0193	aminoacyl-tRNA hydrolase activity
H924_RS04500	COG2070	2-Nitropropane dioxygenase
H924_RS04515	COG0193	aminoacyl-tRNA hydrolase activity
H924_RS04530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H924_RS04535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H924_RS04545	COG2132	Multicopper oxidase
H924_RS04570	COG1309	transcriptional regulator
H924_RS04580	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H924_RS04585	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H924_RS04590	COG0531	amino acid
H924_RS04600	COG3956	TIGRFAM MazG family protein
H924_RS04645	COG1278	Cold shock
H924_RS04655	COG4221	oxidoreductase activity
H924_RS04660	COG1902	pentaerythritol trinitrate reductase activity
H924_RS04665	COG2207	Transcriptional regulator
H924_RS04680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H924_RS04690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H924_RS04700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H924_RS04705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H924_RS04755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H924_RS04760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H924_RS04765	COG1914	H( )-stimulated, divalent metal cation uptake system
H924_RS04770	COG2186	Transcriptional regulator
H924_RS04780	COG0114	fumarate hydratase activity
H924_RS04795	COG1494	fructose-1,6-bisphosphatase
H924_RS04820	COG2963	transposase activity
H924_RS04855	COG2963	transposase activity
H924_RS04860	COG2801	Transposase and inactivated derivatives
H924_RS04890	COG1322	Protein conserved in bacteria
H924_RS04895	COG0628	permease
H924_RS04905	COG0733	neurotransmitter:sodium symporter activity
H924_RS04910	COG0012	GTP binding
H924_RS04955	COG0372	Belongs to the citrate synthase family
H924_RS04960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H924_RS04965	COG2079	MmgE PrpD family protein
H924_RS04970	COG1396	sequence-specific DNA binding
H924_RS04970	COG3800	Transcriptional regulator
H924_RS04990	COG2133	pyrroloquinoline quinone binding
H924_RS05000	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H924_RS05020	COG0488	(ABC) transporter
H924_RS05030	COG2824	Alkylphosphonate utilization operon protein PhnA
H924_RS05040	COG2814	Major facilitator Superfamily
H924_RS05045	COG1104	cysteine desulfurase activity
H924_RS05055	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H924_RS05075	COG4335	DNA alkylation repair
H924_RS05080	COG0095	Lipoate-protein ligase
H924_RS05085	COG2985	domain, Protein
H924_RS05085	COG0569	domain protein
H924_RS05090	COG1609	Transcriptional regulator
H924_RS05100	COG2814	Major facilitator Superfamily
H924_RS05110	COG4721	ABC-type cobalt transport system, permease component
H924_RS05115	COG1122	ATPase activity
H924_RS05130	COG0387	Pfam Sodium calcium exchanger
H924_RS05140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H924_RS05145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H924_RS05155	COG2354	Protein conserved in bacteria
H924_RS05160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H924_RS05190	COG3949	Membrane
H924_RS05205	COG1217	gtp-binding protein TYPA
H924_RS05210	COG4166	transmembrane transport
H924_RS05245	COG2171	N-acyltransferase activity
H924_RS05250	COG1113	amino acid transport
H924_RS05260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H924_RS05270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H924_RS05275	COG0463	Glycosyl transferase, family 2
H924_RS05295	COG0297	glycogen (starch) synthase activity
H924_RS05305	COG4122	O-methyltransferase activity
H924_RS05310	COG1595	DNA-templated transcription, initiation
H924_RS05350	COG0567	Dehydrogenase, E1 component
H924_RS05350	COG0508	dehydrogenase complex catalyzes the overall conversion of
H924_RS05365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H924_RS05375	COG2272	Belongs to the type-B carboxylesterase lipase family
H924_RS05390	COG2814	Major facilitator Superfamily
H924_RS05400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H924_RS05440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H924_RS05445	COG4988	ABC transporter
H924_RS05450	COG1294	oxidase, subunit
H924_RS05455	COG1271	oxidase subunit
H924_RS05465	COG1113	amino acid transport
H924_RS05480	COG1309	transcriptional regulator
H924_RS05485	COG1454	alcohol dehydrogenase
H924_RS05500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H924_RS05505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H924_RS05525	COG2353	YceI-like domain
H924_RS05555	COG0019	diaminopimelate decarboxylase activity
H924_RS05580	COG0460	homoserine dehydrogenase
H924_RS05605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H924_RS05630	COG0356	it plays a direct role in the translocation of protons across the membrane
H924_RS05635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H924_RS05640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H924_RS05665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H924_RS05675	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H924_RS05690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H924_RS05695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H924_RS05700	COG1116	anion transmembrane transporter activity
H924_RS05705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H924_RS05710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H924_RS05715	COG0366	Alpha amylase catalytic
H924_RS05720	COG1119	ATPase activity
H924_RS05740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H924_RS05800	COG0154	amidase activity
H924_RS05815	COG0205	6-phosphofructokinase activity
H924_RS05820	COG1609	Transcriptional regulator
H924_RS05825	COG1129	ABC transporter
H924_RS05830	COG1172	Belongs to the binding-protein-dependent transport system permease family
H924_RS05835	COG1879	ABC-type sugar transport system periplasmic component
H924_RS05850	COG0385	Bile acid
H924_RS05865	COG0667	Aldo Keto reductase
H924_RS05870	COG1279	arginine transmembrane transporter activity
H924_RS05875	COG0583	DNA-binding transcription factor activity
H924_RS05880	COG0435	Glutathione S-transferase
H924_RS05900	COG0640	Transcriptional regulator
H924_RS05905	COG0129	dihydroxy-acid dehydratase activity
H924_RS05915	COG0668	transmembrane transport
H924_RS05920	COG0028	Belongs to the TPP enzyme family
H924_RS05955	COG0473	3-isopropylmalate dehydrogenase activity
H924_RS05970	COG0179	Fumarylacetoacetate (FAA) hydrolase
H924_RS05975	COG0500	methyltransferase
H924_RS06000	COG3655	Transcriptional regulator
H924_RS06045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H924_RS06060	COG1196	nuclear chromosome segregation
H924_RS06065	COG0210	DNA helicase
H924_RS06070	COG3586	endonuclease activity
H924_RS06095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H924_RS06110	COG0058	SHG alpha-glucan phosphorylase activity
H924_RS06115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H924_RS06120	COG0730	response to heat
H924_RS06130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H924_RS06150	COG0406	alpha-ribazole phosphatase activity
H924_RS06150	COG0494	nUDIX hydrolase
H924_RS06175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H924_RS06180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H924_RS06185	COG1461	Dihydroxyacetone kinase
H924_RS06190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H924_RS06200	COG0742	ribosomal rna small subunit methyltransferase
H924_RS06205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H924_RS06230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H924_RS06250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H924_RS06255	COG0640	Transcriptional regulator
H924_RS06260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H924_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
H924_RS06305	COG2226	methyltransferase
H924_RS06345	COG0477	Major facilitator Superfamily
H924_RS06350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H924_RS06355	COG1609	Transcriptional regulator
H924_RS06380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H924_RS06400	COG1733	regulation of RNA biosynthetic process
H924_RS06405	COG0702	epimerase
H924_RS06410	COG3973	AAA domain
H924_RS06455	COG1175	transmembrane transport
H924_RS06470	COG3842	ATPase activity
H924_RS06480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H924_RS06485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H924_RS06490	COG0072	phenylalanine-tRNA ligase activity
H924_RS06490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H924_RS06495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H924_RS06510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H924_RS06515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H924_RS06525	COG0137	argininosuccinate synthase activity
H924_RS06535	COG2835	tetraacyldisaccharide 4'-kinase activity
H924_RS06540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H924_RS06570	COG0647	UMP catabolic process
H924_RS06580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H924_RS06605	COG0494	nUDIX hydrolase
H924_RS06610	COG4974	Belongs to the 'phage' integrase family
H924_RS06620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H924_RS06630	COG2897	thiosulfate sulfurtransferase activity
H924_RS06635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H924_RS06645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H924_RS06650	COG1160	GTP binding
H924_RS06660	COG2226	methyltransferase
H924_RS06670	COG1132	(ABC) transporter
H924_RS06675	COG0428	transporter
H924_RS06680	COG0025	NhaP-type Na H and K H
H924_RS06695	COG3012	SEC-C Motif Domain Protein
H924_RS06705	COG0653	protein targeting
H924_RS06710	COG1716	ATPase activity
H924_RS06740	COG1253	flavin adenine dinucleotide binding
H924_RS06745	COG1253	flavin adenine dinucleotide binding
H924_RS06750	COG0513	Belongs to the DEAD box helicase family
H924_RS06755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H924_RS06765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H924_RS06775	COG0842	Transport permease protein
H924_RS06780	COG0351	phosphomethylpyrimidine kinase
H924_RS06780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H924_RS06780	COG0352	thiamine-phosphate diphosphorylase activity
H924_RS06790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H924_RS06800	COG0477	Major facilitator Superfamily
H924_RS06805	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H924_RS06825	COG0659	secondary active sulfate transmembrane transporter activity
H924_RS06855	COG0463	Glycosyl transferase, family 2
H924_RS06885	COG0300	oxidoreductase activity
H924_RS06905	COG0805	protein transport
H924_RS06910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H924_RS06915	COG2378	regulation of single-species biofilm formation
H924_RS06950	COG1362	aminopeptidase activity
H924_RS06965	COG2814	Major facilitator Superfamily
H924_RS06975	COG1027	Aspartate ammonia-lyase
H924_RS06990	COG0546	phosphoglycolate phosphatase activity
H924_RS06995	COG0646	methionine synthase
H924_RS06995	COG1410	methionine synthase
H924_RS07010	COG0215	cysteine-tRNA ligase activity
H924_RS07015	COG1968	undecaprenyl-diphosphatase activity
H924_RS07020	COG0667	Aldo Keto reductase
H924_RS07040	COG1881	PFAM PEBP family protein
H924_RS07100	COG0791	NLP P60 protein
H924_RS07100	COG3883	PFAM NLP P60 protein
H924_RS07115	COG1309	transcriptional regulator
H924_RS07135	COG3830	Belongs to the UPF0237 family
H924_RS07140	COG2848	UPF0210 protein
H924_RS07145	COG4762	Protein conserved in bacteria
H924_RS07445	COG0488	(ABC) transporter
H924_RS07460	COG0822	iron-sulfur transferase activity
H924_RS07470	COG0396	ATPase activity
H924_RS07495	COG1131	(ABC) transporter
H924_RS07520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H924_RS07525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H924_RS07545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H924_RS07550	COG2423	ornithine cyclodeaminase activity
H924_RS07555	COG0004	ammonium transporteR
H924_RS07560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H924_RS07580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H924_RS07590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H924_RS07600	COG0322	excinuclease ABC activity
H924_RS07645	COG0242	peptide deformylase activity
H924_RS07655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H924_RS07665	COG1758	RNA polymerase activity
H924_RS07670	COG0194	GDP metabolic process
H924_RS07685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H924_RS07690	COG0505	Belongs to the CarA family
H924_RS07695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H924_RS07730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H924_RS07740	COG0006	proline dipeptidase activity
H924_RS07750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H924_RS07755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H924_RS07770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H924_RS07780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H924_RS07785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H924_RS07790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H924_RS07795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H924_RS07830	COG2072	flavoprotein involved in K transport
H924_RS07835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H924_RS07860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H924_RS07870	COG1760	l-serine dehydratase
H924_RS07875	COG0124	histidyl-tRNA synthetase
H924_RS07885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H924_RS07895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H924_RS07900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H924_RS07910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H924_RS07915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H924_RS07930	COG0632	four-way junction helicase activity
H924_RS07935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H924_RS07945	COG1946	Acyl-CoA thioesterase
H924_RS07960	COG0438	transferase activity, transferring glycosyl groups
H924_RS07965	COG1560	Kdo2-lipid A biosynthetic process
H924_RS07970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H924_RS07980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H924_RS07985	COG2837	iron assimilation
H924_RS07990	COG2847	Copper chaperone PCu(A)C
H924_RS08045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H924_RS08050	COG3253	May function as heme-dependent peroxidase
H924_RS08060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H924_RS08065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H924_RS08070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H924_RS08110	COG2311	Membrane
H924_RS08120	COG1061	Type III restriction enzyme res subunit
H924_RS08135	COG2264	protein methyltransferase activity
H924_RS08150	COG1321	iron dependent repressor
H924_RS08155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H924_RS08175	COG0583	DNA-binding transcription factor activity
H924_RS08185	COG1643	Atp-dependent helicase
H924_RS08205	COG1349	DNA-binding transcription factor activity
H924_RS08215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H924_RS08220	COG1349	DNA-binding transcription factor activity
H924_RS08230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H924_RS08230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H924_RS08230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H924_RS08235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H924_RS08245	COG2233	PERMEase
H924_RS08250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H924_RS08260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H924_RS08275	COG1196	nuclear chromosome segregation
H924_RS08295	COG1126	abc transporter atp-binding protein
H924_RS08300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H924_RS08305	COG0765	amino acid transport
H924_RS08310	COG0765	amino acid transport
H924_RS08315	COG2137	regulation of response to DNA damage stimulus
H924_RS08330	COG1268	BioY protein
H924_RS08335	COG1122	ATPase activity
H924_RS08345	COG1842	Phage shock protein A
H924_RS08350	COG1396	sequence-specific DNA binding
H924_RS08375	COG1674	ftsk spoiiie
H924_RS08385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H924_RS08390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H924_RS08395	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H924_RS08400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H924_RS08410	COG1185	polyribonucleotide nucleotidyltransferase activity
H924_RS08445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H924_RS08455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H924_RS08460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H924_RS08465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H924_RS08475	COG0195	Participates in both transcription termination and antitermination
H924_RS08480	COG0779	Required for maturation of 30S ribosomal subunits
H924_RS08490	COG4166	transmembrane transport
H924_RS08495	COG0601	transmembrane transport
H924_RS08500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H924_RS08505	COG4172	Belongs to the ABC transporter superfamily
H924_RS08515	COG3022	response to hydroperoxide
H924_RS08530	COG1648	precorrin-2 dehydrogenase activity
H924_RS08530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H924_RS08585	COG2197	response regulator
H924_RS08590	COG3850	Histidine kinase
H924_RS08595	COG0577	efflux transmembrane transporter activity
H924_RS08600	COG1136	(ABC) transporter
H924_RS08605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H924_RS08610	COG0750	zinc metalloprotease
H924_RS08615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H924_RS08660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H924_RS08675	COG4974	Belongs to the 'phage' integrase family
H924_RS08690	COG0792	nuclease activity
H924_RS08700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H924_RS08705	COG0681	Belongs to the peptidase S26 family
H924_RS08715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H924_RS08720	COG0335	large ribosomal subunit rRNA binding
H924_RS08725	COG0352	thiamine-phosphate diphosphorylase activity
H924_RS08730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H924_RS08730	COG2022	thiamine diphosphate biosynthetic process
H924_RS08740	COG2022	thiamine diphosphate biosynthetic process
H924_RS08765	COG0336	Belongs to the RNA methyltransferase TrmD family
H924_RS08770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H924_RS08790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H924_RS08820	COG1254	Belongs to the acylphosphatase family
H924_RS08830	COG1115	amino acid carrier protein
H924_RS08840	COG0571	ribonuclease III activity
H924_RS08855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H924_RS08860	COG1929	Belongs to the glycerate kinase type-1 family
H924_RS08880	COG2514	catechol 2,3-dioxygenase activity
H924_RS08885	COG0469	pyruvate kinase activity
H924_RS08895	COG0134	indole-3-glycerol-phosphate synthase activity
H924_RS08915	COG0483	inositol monophosphate 1-phosphatase activity
H924_RS08920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H924_RS08925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H924_RS08950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H924_RS09025	COG1739	Uncharacterized protein family UPF0029
H924_RS09045	COG2130	NADP-dependent
H924_RS09050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H924_RS09060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H924_RS09085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H924_RS09095	COG0488	(ABC) transporter
H924_RS09105	COG0252	asparaginase activity
H924_RS09130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H924_RS09135	COG3599	regulation of cell shape
H924_RS09145	COG1799	cell septum assembly
H924_RS09150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H924_RS09155	COG1496	oxidoreductase activity
H924_RS09160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H924_RS09165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H924_RS09170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H924_RS09185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H924_RS09200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H924_RS09205	COG0768	penicillin binding
H924_RS09235	COG0456	acetyltransferase
H924_RS09245	COG0142	geranyltranstransferase activity
H924_RS09260	COG0515	serine threonine protein kinase
H924_RS09260	COG2815	serine threonine protein kinase
H924_RS09275	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H924_RS09300	COG1940	carbohydrate kinase activity
H924_RS09305	COG0438	transferase activity, transferring glycosyl groups
H924_RS09320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H924_RS09325	COG0723	plastoquinol--plastocyanin reductase activity
H924_RS09330	COG2010	Cytochrome c
H924_RS09335	COG1845	cytochrome c oxidase, subunit III
H924_RS09345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H924_RS09375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H924_RS09380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H924_RS09390	COG0508	dehydrogenase complex catalyzes the overall conversion of
H924_RS09410	COG0569	domain protein
H924_RS09410	COG2985	domain, Protein
H924_RS09420	COG0174	glutamine synthetase
H924_RS09445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H924_RS09470	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H924_RS09475	COG0174	glutamine synthetase
H924_RS09500	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H924_RS09515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H924_RS09515	COG3323	Protein of unknown function (DUF1653)
H924_RS09545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H924_RS09550	COG1122	ATPase activity
H924_RS09570	COG0596	Alpha beta hydrolase
H924_RS09575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H924_RS09590	COG0656	L-ascorbic acid biosynthetic process
H924_RS09625	COG3387	PFAM Glycoside hydrolase 15-related
H924_RS09635	COG0358	DNA primase activity
H924_RS09650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H924_RS09655	COG0246	Mannitol dehydrogenase
H924_RS09660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H924_RS09685	COG0423	glycine-tRNA ligase activity
H924_RS09705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H924_RS09715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H924_RS09740	COG0484	heat shock protein binding
H924_RS09780	COG1132	(ABC) transporter
H924_RS09795	COG0339	signal peptide processing
H924_RS09805	COG0366	Alpha amylase catalytic
H924_RS09840	COG1114	Component of the transport system for branched-chain amino acids
H924_RS09845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H924_RS09860	COG0747	negative chemotaxis
H924_RS09865	COG0601	transmembrane transport
H924_RS09870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H924_RS09875	COG4172	Belongs to the ABC transporter superfamily
H924_RS09890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H924_RS09895	COG2224	Isocitrate lyase
H924_RS09910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H924_RS09940	COG0481	GTPase activity
H924_RS09950	COG0268	Binds directly to 16S ribosomal RNA
H924_RS09955	COG1280	lysine exporter protein (LysE YggA)
H924_RS09980	COG1307	EDD domain protein, DegV family
H924_RS09985	COG0406	alpha-ribazole phosphatase activity
H924_RS09995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H924_RS10015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H924_RS10020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H924_RS10055	COG1530	ribonuclease E activity
H924_RS10095	COG0285	dihydrofolate synthase activity
H924_RS10100	COG0525	valine-tRNA ligase activity
H924_RS10105	COG4166	transmembrane transport
H924_RS10110	COG0443	Heat shock 70 kDa protein
H924_RS10125	COG1309	transcriptional regulator
H924_RS10155	COG1414	Transcriptional regulator
H924_RS10160	COG0183	Belongs to the thiolase family
H924_RS10165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H924_RS10175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H924_RS10180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H924_RS10185	COG3485	protocatechuate 3,4-dioxygenase
H924_RS10190	COG3485	protocatechuate 3,4-dioxygenase
H924_RS10200	COG4829	muconolactone delta-isomerase
H924_RS10205	COG4948	Mandelate Racemase Muconate Lactonizing
H924_RS10210	COG3485	protocatechuate 3,4-dioxygenase
H924_RS10215	COG4638	Rieske (2fe-2S)
H924_RS10220	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H924_RS10250	COG0740	serine-type endopeptidase activity
H924_RS10255	COG0740	serine-type endopeptidase activity
H924_RS10260	COG0544	peptidyl-prolyl cis-trans isomerase activity
H924_RS10295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H924_RS10330	COG4172	Belongs to the ABC transporter superfamily
H924_RS10335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H924_RS10345	COG0747	negative chemotaxis
H924_RS10360	COG4221	oxidoreductase activity
H924_RS10375	COG0668	transmembrane transport
H924_RS10425	COG3842	ATPase activity
H924_RS10460	COG3842	ATPase activity
H924_RS10465	COG0463	Glycosyl transferase, family 2
H924_RS10480	COG2801	Transposase and inactivated derivatives
H924_RS10485	COG3622	Belongs to the hyi family
H924_RS10490	COG1028	Short-chain dehydrogenase reductase Sdr
H924_RS10500	COG2382	esterase
H924_RS10505	COG1376	ErfK ybiS ycfS ynhG family protein
H924_RS10540	COG2066	Belongs to the glutaminase family
H924_RS10545	COG3265	gluconokinase activity
H924_RS10550	COG1335	isochorismatase
H924_RS10570	COG0736	holo-[acyl-carrier-protein] synthase activity
H924_RS10575	COG2814	Major facilitator Superfamily
H924_RS10605	COG1566	PFAM secretion protein HlyD family protein
H924_RS10625	COG1234	tRNA 3'-trailer cleavage
H924_RS10630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H924_RS10640	COG1846	Transcriptional regulator
H924_RS10650	COG3191	aminopeptidase activity
H924_RS10670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H924_RS10700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H924_RS10715	COG2186	Transcriptional regulator
H924_RS10720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H924_RS10740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H924_RS10755	COG0604	alcohol dehydrogenase
H924_RS10780	COG0033	Phosphoglucomutase
H924_RS10785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H924_RS10790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H924_RS10800	COG1823	symporter activity
H924_RS10810	COG0577	efflux transmembrane transporter activity
H924_RS10810	COG1136	(ABC) transporter
H924_RS10815	COG0129	dihydroxy-acid dehydratase activity
H924_RS10840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H924_RS10850	COG2197	response regulator
H924_RS10860	COG1045	serine acetyltransferase
H924_RS10885	COG0045	succinate-CoA ligase (ADP-forming) activity
H924_RS10900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H924_RS10930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H924_RS10935	COG0581	inorganic phosphate transmembrane transporter activity
H924_RS10950	COG0456	acetyltransferase
H924_RS10960	COG1597	lipid kinase activity
H924_RS10985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H924_RS11015	COG0047	phosphoribosylformylglycinamidine synthase activity
H924_RS11020	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H924_RS11025	COG0386	Belongs to the glutathione peroxidase family
H924_RS11055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H924_RS11060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H924_RS11065	COG0436	Aminotransferase
H924_RS11070	COG0151	Belongs to the GarS family
H924_RS11075	COG0537	adenosine 5'-monophosphoramidase activity
H924_RS11085	COG2205	protein histidine kinase activity
H924_RS11090	COG0745	RESPONSE REGULATOR receiver
H924_RS11105	COG0028	Belongs to the TPP enzyme family
H924_RS11110	COG0477	Major facilitator Superfamily
H924_RS11115	COG1309	transcriptional regulator
H924_RS11135	COG2837	iron assimilation
H924_RS11145	COG0672	)-iron permease
H924_RS11235	COG1609	Transcriptional regulator
H924_RS11245	COG1121	(ABC) transporter
H924_RS11250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H924_RS11255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H924_RS11270	COG1621	beta-fructofuranosidase activity
H924_RS11280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H924_RS11285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H924_RS11310	COG4166	transmembrane transport
H924_RS11320	COG0444	Belongs to the ABC transporter superfamily
H924_RS11325	COG4608	Belongs to the ABC transporter superfamily
H924_RS11335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H924_RS11345	COG2847	Copper chaperone PCu(A)C
H924_RS11350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H924_RS11375	COG0542	response to heat
H924_RS11385	COG2814	Major facilitator Superfamily
H924_RS11390	COG0477	Major facilitator Superfamily
H924_RS11400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H924_RS11440	COG0302	gtp cyclohydrolase
H924_RS11445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H924_RS11455	COG0037	tRNA processing
H924_RS11460	COG2027	D-alanyl-D-alanine carboxypeptidase
H924_RS11465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H924_RS11470	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H924_RS11495	COG3711	transcriptional antiterminator
H924_RS11500	COG2723	6-phospho-beta-galactosidase activity
H924_RS11510	COG0425	Belongs to the sulfur carrier protein TusA family
H924_RS11510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H924_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
H924_RS11570	COG2326	polyphosphate kinase activity
H924_RS11580	COG0459	protein refolding
H924_RS11590	COG1100	Small GTP-binding protein
H924_RS11640	COG2111	Na H antiporter
H924_RS11640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H924_RS11645	COG1006	Multisubunit Na H antiporter MnhC subunit
H924_RS11650	COG0651	ATP synthesis coupled electron transport
H924_RS11660	COG2212	antiporter activity
H924_RS11665	COG1320	monovalent cation:proton antiporter activity
H924_RS11695	COG0242	peptide deformylase activity
H924_RS11715	COG2814	Major facilitator Superfamily
H924_RS11725	COG0384	phenazine biosynthesis protein PhzF
H924_RS11755	COG0515	serine threonine protein kinase
H924_RS11760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H924_RS11765	COG0280	phosphate acetyltransferase
H924_RS11785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H924_RS11795	COG4129	membrane
H924_RS11800	COG0191	fructose-bisphosphate aldolase activity
H924_RS11815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H924_RS11845	COG0542	response to heat
H924_RS11885	COG1012	belongs to the aldehyde dehydrogenase family
H924_RS11890	COG0789	Transcriptional regulator
H924_RS11895	COG0484	heat shock protein binding
H924_RS11900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H924_RS11905	COG0443	Heat shock 70 kDa protein
H924_RS11910	COG0628	permease
H924_RS11925	COG0730	response to heat
H924_RS11955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H924_RS11975	COG0778	Nitroreductase
H924_RS11995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H924_RS12005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H924_RS12025	COG0519	Catalyzes the synthesis of GMP from XMP
H924_RS12035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H924_RS12065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H924_RS12085	COG1472	Belongs to the glycosyl hydrolase 3 family
H924_RS12100	COG4981	capsule polysaccharide biosynthetic process
H924_RS12115	COG0297	glycogen (starch) synthase activity
H924_RS12125	COG0500	methyltransferase
H924_RS12175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H924_RS12180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H924_RS12180	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H924_RS12180	COG3321	synthase
H924_RS12185	COG0318	PFAM AMP-dependent synthetase and ligase
H924_RS12190	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
H924_RS12200	COG5479	isomerase activity
H924_RS12200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H924_RS12210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H924_RS12215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H924_RS12220	COG0671	phosphoesterase, PA-phosphatase related
H924_RS12225	COG1216	Glycosyl transferase, family 2
H924_RS12235	COG0671	phosphoesterase, PA-phosphatase related
H924_RS12275	COG0561	phosphatase activity
H924_RS12285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H924_RS12290	COG2188	Transcriptional regulator
H924_RS12310	COG0077	Prephenate dehydratase
H924_RS12330	COG1316	TRANSCRIPTIONal
H924_RS12355	COG2186	Transcriptional regulator
H924_RS12375	COG1914	H( )-stimulated, divalent metal cation uptake system
H924_RS12395	COG1011	Hydrolase
H924_RS12410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H924_RS12420	COG0477	Major facilitator Superfamily
H924_RS12435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H924_RS12445	COG0569	domain protein
H924_RS12450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H924_RS12455	COG0583	DNA-binding transcription factor activity
H924_RS12460	COG2814	Major facilitator Superfamily
H924_RS12480	COG2197	response regulator
H924_RS12500	COG3764	Sortase (surface protein transpeptidase)
H924_RS12505	COG0706	membrane insertase activity
H924_RS12525	COG0564	pseudouridine synthase activity
H924_RS12590	COG1842	Phage shock protein A
H924_RS12595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H924_RS12605	COG0477	Major facilitator Superfamily
H924_RS12610	COG1695	Transcriptional regulator
H924_RS12615	COG0305	Participates in initiation and elongation during chromosome replication
H924_RS12620	COG0359	binds to the 23S rRNA
H924_RS12625	COG0629	single-stranded DNA binding
H924_RS12630	COG0360	Binds together with S18 to 16S ribosomal RNA
H924_RS12645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H924_RS12675	COG1054	Belongs to the UPF0176 family
H924_RS12685	COG4868	Belongs to the UPF0371 family
H924_RS12700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H924_RS12715	COG2814	Major facilitator Superfamily
H924_RS12740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H924_RS12745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H924_RS12755	COG0778	Nitroreductase
H924_RS12765	COG3093	addiction module antidote protein HigA
H924_RS12775	COG0179	Fumarylacetoacetate (FAA) hydrolase
H924_RS12790	COG2814	Major facilitator Superfamily
H924_RS12795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H924_RS12805	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H924_RS12820	COG1174	glycine betaine transport
H924_RS12825	COG1174	glycine betaine transport
H924_RS12835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H924_RS12840	COG0512	Glutamine amidotransferase of anthranilate synthase
H924_RS12850	COG0135	phosphoribosylanthranilate isomerase activity
H924_RS12850	COG0134	indole-3-glycerol-phosphate synthase activity
H924_RS12855	COG0133	tryptophan synthase activity
H924_RS12860	COG0159	tryptophan synthase activity
H924_RS12875	COG1131	(ABC) transporter
H924_RS12915	COG3104	oligopeptide transport
H924_RS12920	COG1959	2 iron, 2 sulfur cluster binding
H924_RS12925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H924_RS12925	COG1017	nitric oxide dioxygenase activity
H924_RS12930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H924_RS12935	COG0477	Major facilitator Superfamily
H924_RS12965	COG1484	DNA-dependent DNA replication
H924_RS12980	COG0351	phosphomethylpyrimidine kinase
H924_RS12990	COG2608	mercury ion transmembrane transporter activity
H924_RS12995	COG0477	Major facilitator Superfamily
H924_RS13015	COG1414	Transcriptional regulator
H924_RS13025	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H924_RS13030	COG1678	Uncharacterized ACR, COG1678
H924_RS13035	COG0617	tRNA 3'-terminal CCA addition
H924_RS13055	COG1595	DNA-templated transcription, initiation
H924_RS13065	COG3118	belongs to the thioredoxin family
H924_RS13070	COG0860	N-Acetylmuramoyl-L-alanine amidase
H924_RS13070	COG3409	Peptidoglycan-binding domain 1 protein
H924_RS13085	COG1192	Involved in chromosome partitioning
H924_RS13100	COG0594	ribonuclease P activity
H924_RS13210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H924_RS13315	COG0493	'glutamate synthase
H924_RS13655	COG4969	Belongs to the N-Me-Phe pilin family
H924_RS13670	COG0582	viral genome integration into host DNA