locus-tag	class	description
CD31A_RS00010	COG0592	DNA-directed DNA polymerase activity
CD31A_RS00025	COG0187	DNA topoisomerase II activity
CD31A_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CD31A_RS00070	COG1620	l-lactate permease
CD31A_RS00080	COG4988	ABC transporter
CD31A_RS00085	COG1132	(ABC) transporter
CD31A_RS00120	COG4211	Belongs to the binding-protein-dependent transport system permease family
CD31A_RS00140	COG2801	Transposase and inactivated derivatives
CD31A_RS00155	COG0352	thiamine-phosphate diphosphorylase activity
CD31A_RS00160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD31A_RS00160	COG2022	thiamine diphosphate biosynthetic process
CD31A_RS00180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CD31A_RS00180	COG0352	thiamine-phosphate diphosphorylase activity
CD31A_RS00180	COG0351	phosphomethylpyrimidine kinase
CD31A_RS00220	COG0515	serine threonine protein kinase
CD31A_RS00220	COG2815	serine threonine protein kinase
CD31A_RS00225	COG0515	serine threonine protein kinase
CD31A_RS00230	COG0768	penicillin binding
CD31A_RS00250	COG1716	ATPase activity
CD31A_RS00250	COG1716	ATPase activity
CD31A_RS00270	COG2217	Heavy metal translocating P-type atpase
CD31A_RS00280	COG2205	protein histidine kinase activity
CD31A_RS00285	COG0745	RESPONSE REGULATOR receiver
CD31A_RS00290	COG3547	Transposase (IS116 IS110 IS902 family)
CD31A_RS00300	COG2132	Multicopper oxidase
CD31A_RS00335	COG3547	Transposase (IS116 IS110 IS902 family)
CD31A_RS00360	COG0789	Transcriptional regulator
CD31A_RS00375	COG2076	Multidrug Resistance protein
CD31A_RS00390	COG2072	flavoprotein involved in K transport
CD31A_RS00400	COG0798	PFAM Bile acid sodium symporter
CD31A_RS00405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CD31A_RS00420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CD31A_RS00425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CD31A_RS00505	COG1131	(ABC) transporter
CD31A_RS00510	COG2197	response regulator
CD31A_RS00515	COG4585	Histidine kinase
CD31A_RS00525	COG1174	glycine betaine transport
CD31A_RS00530	COG1174	glycine betaine transport
CD31A_RS00535	COG0517	IMP dehydrogenase activity
CD31A_RS00535	COG1125	glycine betaine transport
CD31A_RS00545	COG1595	DNA-templated transcription, initiation
CD31A_RS00580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS00585	COG1120	ATPase activity
CD31A_RS00595	COG5646	InterPro IPR014922
CD31A_RS00600	COG0415	Belongs to the DNA photolyase family
CD31A_RS00635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CD31A_RS00660	COG1846	Transcriptional regulator
CD31A_RS00665	COG3180	Ammonia monooxygenase
CD31A_RS00680	COG1643	Atp-dependent helicase
CD31A_RS00720	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS00725	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS00740	COG2501	S4 domain
CD31A_RS00765	COG3590	peptidase
CD31A_RS00800	COG1028	Short-chain dehydrogenase reductase Sdr
CD31A_RS00805	COG0277	FAD linked oxidase domain protein
CD31A_RS00835	COG1216	Glycosyl transferase, family 2
CD31A_RS00840	COG0803	Belongs to the bacterial solute-binding protein 9 family
CD31A_RS00845	COG1121	(ABC) transporter
CD31A_RS00850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CD31A_RS00855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CD31A_RS00860	COG0803	Belongs to the bacterial solute-binding protein 9 family
CD31A_RS00880	COG0604	alcohol dehydrogenase
CD31A_RS00910	COG0471	metal ion transport
CD31A_RS00935	COG4974	Belongs to the 'phage' integrase family
CD31A_RS01145	COG0726	polysaccharide deacetylase
CD31A_RS01150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD31A_RS01215	COG0287	Prephenate dehydrogenase
CD31A_RS01240	COG2409	Drug exporters of the RND superfamily
CD31A_RS01245	COG0343	queuine tRNA-ribosyltransferase activity
CD31A_RS01255	COG2610	gluconate transmembrane transporter activity
CD31A_RS01260	COG3265	gluconokinase activity
CD31A_RS01265	COG1063	alcohol dehydrogenase
CD31A_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
CD31A_RS01285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD31A_RS01315	COG1492	cobalamin metabolic process
CD31A_RS01320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CD31A_RS01335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CD31A_RS01340	COG2390	Transcriptional regulator
CD31A_RS01355	COG2814	Major facilitator Superfamily
CD31A_RS01365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CD31A_RS01375	COG0697	spore germination
CD31A_RS01380	COG0527	aspartate kinase activity
CD31A_RS01455	COG2271	Major facilitator Superfamily
CD31A_RS01460	COG0745	RESPONSE REGULATOR receiver
CD31A_RS01485	COG0651	ATP synthesis coupled electron transport
CD31A_RS01490	COG1006	Multisubunit Na H antiporter MnhC subunit
CD31A_RS01495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CD31A_RS01495	COG2111	Na H antiporter
CD31A_RS01525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CD31A_RS01545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD31A_RS01550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CD31A_RS01630	COG1205	dead DEAH box helicase
CD31A_RS01630	COG1111	helicase
CD31A_RS01635	COG1278	Cold shock
CD31A_RS01640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CD31A_RS01645	COG3842	ATPase activity
CD31A_RS01670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CD31A_RS01670	COG1754	DNA topoisomerase type I activity
CD31A_RS01685	COG1297	OPT oligopeptide transporter protein
CD31A_RS01720	COG4974	Belongs to the 'phage' integrase family
CD31A_RS01745	COG2801	Transposase and inactivated derivatives
CD31A_RS01765	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS01770	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS01775	COG3177	Filamentation induced by cAMP protein fic
CD31A_RS01800	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS01805	COG0318	PFAM AMP-dependent synthetase and ligase
CD31A_RS01815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CD31A_RS01825	COG1088	dTDP-glucose 4,6-dehydratase activity
CD31A_RS01835	COG1505	serine-type exopeptidase activity
CD31A_RS01845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD31A_RS01850	COG3800	Transcriptional regulator
CD31A_RS01850	COG1396	sequence-specific DNA binding
CD31A_RS01860	COG1053	succinate dehydrogenase
CD31A_RS01865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CD31A_RS01875	COG2733	membrane
CD31A_RS01885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CD31A_RS01895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CD31A_RS01905	COG1882	Formate acetyltransferase
CD31A_RS01925	COG0318	PFAM AMP-dependent synthetase and ligase
CD31A_RS01930	COG0318	PFAM AMP-dependent synthetase and ligase
CD31A_RS01945	COG5002	protein histidine kinase activity
CD31A_RS01965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CD31A_RS01975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CD31A_RS01975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CD31A_RS02000	COG1648	precorrin-2 dehydrogenase activity
CD31A_RS02000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CD31A_RS02005	COG0113	porphobilinogen synthase activity
CD31A_RS02040	COG0406	alpha-ribazole phosphatase activity
CD31A_RS02050	COG0785	Cytochrome C biogenesis protein
CD31A_RS02060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CD31A_RS02095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CD31A_RS02100	COG4948	Mandelate Racemase Muconate Lactonizing
CD31A_RS02115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD31A_RS02115	COG0438	transferase activity, transferring glycosyl groups
CD31A_RS02120	COG2226	methyltransferase
CD31A_RS02125	COG0039	L-malate dehydrogenase activity
CD31A_RS02130	COG0644	oxidoreductase
CD31A_RS02135	COG0142	geranyltranstransferase activity
CD31A_RS02160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CD31A_RS02190	COG0803	Belongs to the bacterial solute-binding protein 9 family
CD31A_RS02200	COG1121	(ABC) transporter
CD31A_RS02205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CD31A_RS02270	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS02285	COG4585	Histidine kinase
CD31A_RS02290	COG2197	response regulator
CD31A_RS02295	COG1131	(ABC) transporter
CD31A_RS02310	COG0701	Predicted permease
CD31A_RS02355	COG0051	transcription antitermination factor activity, RNA binding
CD31A_RS02415	COG1136	(ABC) transporter
CD31A_RS02420	COG0577	efflux transmembrane transporter activity
CD31A_RS02440	COG0814	amino acid
CD31A_RS02445	COG1760	l-serine dehydratase
CD31A_RS02450	COG0252	asparaginase activity
CD31A_RS02460	COG0521	Mo-molybdopterin cofactor biosynthetic process
CD31A_RS02490	COG1140	nitrate reductase beta subunit
CD31A_RS02515	COG0746	molybdenum cofactor guanylyltransferase activity
CD31A_RS02520	COG0315	cyclic pyranopterin monophosphate synthase activity
CD31A_RS02540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD31A_RS02550	COG0444	Belongs to the ABC transporter superfamily
CD31A_RS02555	COG0601	transmembrane transport
CD31A_RS02560	COG0747	negative chemotaxis
CD31A_RS02565	COG2186	Transcriptional regulator
CD31A_RS02580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CD31A_RS02635	COG0366	Alpha amylase catalytic
CD31A_RS02650	COG1175	transmembrane transport
CD31A_RS02655	COG3833	ABC-type maltose transport systems, permease component
CD31A_RS02670	COG3842	ATPase activity
CD31A_RS02675	COG0201	protein transport
CD31A_RS02735	COG3266	domain, Protein
CD31A_RS02745	COG1404	Belongs to the peptidase S8 family
CD31A_RS02815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CD31A_RS02840	COG0456	acetyltransferase
CD31A_RS02880	COG0516	GMP reductase activity
CD31A_RS02885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CD31A_RS02890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS02895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS02900	COG1120	ATPase activity
CD31A_RS03000	COG0668	transmembrane transport
CD31A_RS03005	COG2011	ABC-type metal ion transport system permease component
CD31A_RS03020	COG1464	Belongs to the NlpA lipoprotein family
CD31A_RS03040	COG0803	Belongs to the bacterial solute-binding protein 9 family
CD31A_RS03045	COG1121	(ABC) transporter
CD31A_RS03050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CD31A_RS03100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS03105	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CD31A_RS03115	COG2873	o-acetylhomoserine
CD31A_RS03120	COG2838	Isocitrate dehydrogenase
CD31A_RS03125	COG2814	Major facilitator Superfamily
CD31A_RS03140	COG0180	Tryptophanyl-tRNA synthetase
CD31A_RS03145	COG1295	ribonuclease BN
CD31A_RS03150	COG1686	Belongs to the peptidase S11 family
CD31A_RS03165	COG0791	NLP P60 protein
CD31A_RS03185	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CD31A_RS03185	COG1473	amidohydrolase
CD31A_RS03210	COG4770	biotin carboxylase activity
CD31A_RS03215	COG2897	thiosulfate sulfurtransferase activity
CD31A_RS03220	COG0189	ligase activity
CD31A_RS03240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD31A_RS03255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CD31A_RS03265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CD31A_RS03270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CD31A_RS03270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CD31A_RS03295	COG0409	Hydrogenase expression formation protein
CD31A_RS03300	COG0298	carbon dioxide binding
CD31A_RS03310	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CD31A_RS03315	COG0375	protein maturation
CD31A_RS03320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CD31A_RS03330	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CD31A_RS03335	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CD31A_RS03340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CD31A_RS03345	COG0375	protein maturation
CD31A_RS03355	COG0298	carbon dioxide binding
CD31A_RS03365	COG1316	TRANSCRIPTIONal
CD31A_RS03375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CD31A_RS03405	COG1482	cell wall glycoprotein biosynthetic process
CD31A_RS03430	COG0745	RESPONSE REGULATOR receiver
CD31A_RS03435	COG5002	protein histidine kinase activity
CD31A_RS03450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CD31A_RS03485	COG1162	GTPase activity
CD31A_RS03490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CD31A_RS03495	COG2135	peptidase activity
CD31A_RS03500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CD31A_RS03535	COG0513	Belongs to the DEAD box helicase family
CD31A_RS03565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CD31A_RS03570	COG2816	NAD+ diphosphatase activity
CD31A_RS03595	COG3480	Lon protease (S16) C-terminal proteolytic domain
CD31A_RS03650	COG3842	ATPase activity
CD31A_RS03660	COG3547	Transposase (IS116 IS110 IS902 family)
CD31A_RS03700	COG2801	Transposase and inactivated derivatives
CD31A_RS03810	COG0483	inositol monophosphate 1-phosphatase activity
CD31A_RS03815	COG0483	inositol monophosphate 1-phosphatase activity
CD31A_RS03825	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CD31A_RS03835	COG2226	methyltransferase
CD31A_RS03850	COG2177	Part of the ABC transporter FtsEX involved in
CD31A_RS03855	COG2884	Cell division ATP-binding protein ftsE
CD31A_RS03900	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS03955	COG1652	LysM domain
CD31A_RS03960	COG1278	Cold shock
CD31A_RS03985	COG2252	PERMEase
CD31A_RS03990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CD31A_RS04010	COG0372	Belongs to the citrate synthase family
CD31A_RS04015	COG0545	Peptidyl-prolyl cis-trans isomerase
CD31A_RS04025	COG0656	L-ascorbic acid biosynthetic process
CD31A_RS04040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD31A_RS04050	COG3757	hydrolase, family 25
CD31A_RS04055	COG0475	glutathione-regulated potassium exporter activity
CD31A_RS04055	COG0589	response to stress
CD31A_RS04090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CD31A_RS04110	COG1201	RNA secondary structure unwinding
CD31A_RS04120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CD31A_RS04130	COG3304	Inner membrane component domain
CD31A_RS04195	COG1309	transcriptional regulator
CD31A_RS04240	COG0745	RESPONSE REGULATOR receiver
CD31A_RS04245	COG2205	protein histidine kinase activity
CD31A_RS04250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD31A_RS04280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CD31A_RS04310	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CD31A_RS04315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CD31A_RS04320	COG3949	Membrane
CD31A_RS04335	COG0084	hydrolase, TatD family'
CD31A_RS04340	COG3583	domain protein
CD31A_RS04355	COG0488	(ABC) transporter
CD31A_RS04380	COG2326	polyphosphate kinase activity
CD31A_RS04390	COG0561	phosphatase activity
CD31A_RS04420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CD31A_RS04430	COG0193	aminoacyl-tRNA hydrolase activity
CD31A_RS04450	COG1523	belongs to the glycosyl hydrolase 13 family
CD31A_RS04455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CD31A_RS04480	COG1132	(ABC) transporter
CD31A_RS04485	COG1132	(ABC) transporter
CD31A_RS04510	COG0531	amino acid
CD31A_RS04515	COG3956	TIGRFAM MazG family protein
CD31A_RS04575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CD31A_RS04630	COG0114	fumarate hydratase activity
CD31A_RS04635	COG1494	fructose-1,6-bisphosphatase
CD31A_RS04675	COG0733	neurotransmitter:sodium symporter activity
CD31A_RS04680	COG0012	GTP binding
CD31A_RS04685	COG2354	Protein conserved in bacteria
CD31A_RS04705	COG1122	ATPase activity
CD31A_RS04720	COG4166	transmembrane transport
CD31A_RS04725	COG0601	transmembrane transport
CD31A_RS04730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD31A_RS04740	COG1122	ATPase activity
CD31A_RS04765	COG2801	Transposase and inactivated derivatives
CD31A_RS04770	COG5640	endopeptidase activity
CD31A_RS04790	COG1217	gtp-binding protein TYPA
CD31A_RS04820	COG0564	pseudouridine synthase activity
CD31A_RS04835	COG1113	amino acid transport
CD31A_RS04845	COG1113	amino acid transport
CD31A_RS04855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD31A_RS04860	COG1611	Belongs to the LOG family
CD31A_RS04865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CD31A_RS04870	COG0463	Glycosyl transferase, family 2
CD31A_RS04890	COG3527	Alpha-acetolactate decarboxylase
CD31A_RS04895	COG0297	glycogen (starch) synthase activity
CD31A_RS04935	COG2239	Acts as a magnesium transporter
CD31A_RS04950	COG0567	Dehydrogenase, E1 component
CD31A_RS04950	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD31A_RS04955	COG1132	(ABC) transporter
CD31A_RS04970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CD31A_RS04975	COG2272	Belongs to the type-B carboxylesterase lipase family
CD31A_RS05000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD31A_RS05015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CD31A_RS05025	COG0494	nUDIX hydrolase
CD31A_RS05050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD31A_RS05055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CD31A_RS05075	COG2353	YceI-like domain
CD31A_RS05095	COG1556	Lactate utilization protein
CD31A_RS05100	COG1139	Iron-sulfur cluster binding protein
CD31A_RS05110	COG1620	l-lactate permease
CD31A_RS05120	COG0019	diaminopimelate decarboxylase activity
CD31A_RS05125	COG0460	homoserine dehydrogenase
CD31A_RS05145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CD31A_RS05145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CD31A_RS05175	COG0356	it plays a direct role in the translocation of protons across the membrane
CD31A_RS05180	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD31A_RS05235	COG1120	ATPase activity
CD31A_RS05240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS05245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS05250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD31A_RS05275	COG1119	ATPase activity
CD31A_RS05295	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CD31A_RS05305	COG1104	cysteine desulfurase activity
CD31A_RS05335	COG0281	malic enzyme
CD31A_RS05350	COG1214	PFAM Peptidase M22, glycoprotease
CD31A_RS05350	COG0456	acetyltransferase
CD31A_RS05365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS05370	COG1120	ATPase activity
CD31A_RS05385	COG0205	6-phosphofructokinase activity
CD31A_RS05395	COG0667	Aldo Keto reductase
CD31A_RS05405	COG0583	DNA-binding transcription factor activity
CD31A_RS05410	COG0435	Glutathione S-transferase
CD31A_RS05435	COG0028	Belongs to the TPP enzyme family
CD31A_RS05495	COG0179	Fumarylacetoacetate (FAA) hydrolase
CD31A_RS05545	COG2409	Drug exporters of the RND superfamily
CD31A_RS05550	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CD31A_RS05570	COG2824	Alkylphosphonate utilization operon protein PhnA
CD31A_RS05600	COG0494	nUDIX hydrolase
CD31A_RS05600	COG0406	alpha-ribazole phosphatase activity
CD31A_RS05620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CD31A_RS05625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CD31A_RS05630	COG1461	Dihydroxyacetone kinase
CD31A_RS05635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CD31A_RS05645	COG0742	ribosomal rna small subunit methyltransferase
CD31A_RS05665	COG0765	amino acid transport
CD31A_RS05695	COG0539	negative regulation of cytoplasmic translation
CD31A_RS05700	COG3069	C4-dicarboxylate transmembrane transporter activity
CD31A_RS05705	COG3711	transcriptional antiterminator
CD31A_RS05745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD31A_RS05805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CD31A_RS05830	COG2835	tetraacyldisaccharide 4'-kinase activity
CD31A_RS05865	COG0647	UMP catabolic process
CD31A_RS05895	COG0494	nUDIX hydrolase
CD31A_RS05900	COG4974	Belongs to the 'phage' integrase family
CD31A_RS05920	COG3104	oligopeptide transport
CD31A_RS05925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CD31A_RS05940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CD31A_RS05955	COG1160	GTP binding
CD31A_RS05960	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CD31A_RS05965	COG0500	methyltransferase
CD31A_RS05970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CD31A_RS06025	COG1253	flavin adenine dinucleotide binding
CD31A_RS06030	COG0513	Belongs to the DEAD box helicase family
CD31A_RS06035	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CD31A_RS06045	COG0598	Magnesium transport protein CorA
CD31A_RS06105	COG0463	Glycosyl transferase, family 2
CD31A_RS06110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CD31A_RS06125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CD31A_RS06165	COG4581	dead DEAH box helicase
CD31A_RS06170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CD31A_RS06175	COG0805	protein transport
CD31A_RS06220	COG1362	aminopeptidase activity
CD31A_RS06240	COG1027	Aspartate ammonia-lyase
CD31A_RS06245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CD31A_RS06265	COG0646	methionine synthase
CD31A_RS06265	COG1410	methionine synthase
CD31A_RS06300	COG1881	PFAM PEBP family protein
CD31A_RS06380	COG0791	NLP P60 protein
CD31A_RS06380	COG3883	PFAM NLP P60 protein
CD31A_RS06405	COG2848	UPF0210 protein
CD31A_RS06410	COG0488	(ABC) transporter
CD31A_RS06415	COG2151	metal-sulfur cluster biosynthetic enzyme
CD31A_RS06420	COG0822	iron-sulfur transferase activity
CD31A_RS06425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CD31A_RS06430	COG0396	ATPase activity
CD31A_RS06435	COG0719	Fe-S assembly protein
CD31A_RS06455	COG1131	(ABC) transporter
CD31A_RS06475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CD31A_RS06480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CD31A_RS06500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CD31A_RS06515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CD31A_RS06525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CD31A_RS06580	COG0242	peptide deformylase activity
CD31A_RS06620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CD31A_RS06630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CD31A_RS06645	COG1090	epimerase
CD31A_RS06670	COG0006	proline dipeptidase activity
CD31A_RS06695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CD31A_RS06755	COG1760	l-serine dehydratase
CD31A_RS06765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD31A_RS06770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CD31A_RS06785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CD31A_RS06800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CD31A_RS06835	COG1946	Acyl-CoA thioesterase
CD31A_RS06845	COG2801	Transposase and inactivated derivatives
CD31A_RS06850	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS06885	COG0785	Cytochrome C biogenesis protein
CD31A_RS06905	COG0156	8-amino-7-oxononanoate synthase activity
CD31A_RS06915	COG0438	transferase activity, transferring glycosyl groups
CD31A_RS06920	COG1560	Kdo2-lipid A biosynthetic process
CD31A_RS06925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CD31A_RS06940	COG2837	iron assimilation
CD31A_RS06975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CD31A_RS06980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CD31A_RS06985	COG3253	May function as heme-dependent peroxidase
CD31A_RS07105	COG0450	alkyl hydroperoxide reductase
CD31A_RS07120	COG1643	Atp-dependent helicase
CD31A_RS07135	COG1349	DNA-binding transcription factor activity
CD31A_RS07140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CD31A_RS07145	COG1349	DNA-binding transcription factor activity
CD31A_RS07150	COG1105	Belongs to the carbohydrate kinase PfkB family
CD31A_RS07160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD31A_RS07165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD31A_RS07175	COG2233	PERMEase
CD31A_RS07180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CD31A_RS07195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CD31A_RS07210	COG1196	nuclear chromosome segregation
CD31A_RS07245	COG1268	BioY protein
CD31A_RS07250	COG1122	ATPase activity
CD31A_RS07255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CD31A_RS07260	COG1842	Phage shock protein A
CD31A_RS07265	COG1396	sequence-specific DNA binding
CD31A_RS07290	COG1674	ftsk spoiiie
CD31A_RS07300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CD31A_RS07350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CD31A_RS07355	COG0534	Mate efflux family protein
CD31A_RS07400	COG3022	response to hydroperoxide
CD31A_RS07410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CD31A_RS07415	COG0523	cobalamin synthesis protein
CD31A_RS07420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CD31A_RS07420	COG2169	Transcriptional regulator
CD31A_RS07470	COG0768	penicillin binding
CD31A_RS07480	COG0750	zinc metalloprotease
CD31A_RS07535	COG4974	Belongs to the 'phage' integrase family
CD31A_RS07565	COG0681	Belongs to the peptidase S26 family
CD31A_RS07600	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CD31A_RS07635	COG1115	amino acid carrier protein
CD31A_RS07695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CD31A_RS07700	COG1929	Belongs to the glycerate kinase type-1 family
CD31A_RS07720	COG0058	SHG alpha-glucan phosphorylase activity
CD31A_RS07725	COG0469	pyruvate kinase activity
CD31A_RS07755	COG0483	inositol monophosphate 1-phosphatase activity
CD31A_RS07845	COG1739	Uncharacterized protein family UPF0029
CD31A_RS07850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CD31A_RS07875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CD31A_RS07890	COG0252	asparaginase activity
CD31A_RS07910	COG3599	regulation of cell shape
CD31A_RS07920	COG1799	cell septum assembly
CD31A_RS07925	COG1496	oxidoreductase activity
CD31A_RS07930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CD31A_RS07935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CD31A_RS07970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CD31A_RS07975	COG0768	penicillin binding
CD31A_RS08015	COG0142	geranyltranstransferase activity
CD31A_RS08030	COG2815	serine threonine protein kinase
CD31A_RS08030	COG0515	serine threonine protein kinase
CD31A_RS08035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CD31A_RS08050	COG1940	carbohydrate kinase activity
CD31A_RS08055	COG0438	transferase activity, transferring glycosyl groups
CD31A_RS08065	COG0791	NLP P60 protein
CD31A_RS08120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CD31A_RS08130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CD31A_RS08145	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD31A_RS08170	COG0174	glutamine synthetase
CD31A_RS08185	COG2056	Na+-H+ antiporter family
CD31A_RS08205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CD31A_RS08230	COG0174	glutamine synthetase
CD31A_RS08310	COG3323	Protein of unknown function (DUF1653)
CD31A_RS08310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CD31A_RS08335	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CD31A_RS08350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CD31A_RS08370	COG0596	Alpha beta hydrolase
CD31A_RS08395	COG2860	membrane
CD31A_RS08465	COG0423	glycine-tRNA ligase activity
CD31A_RS08570	COG2272	Belongs to the type-B carboxylesterase lipase family
CD31A_RS08600	COG1132	(ABC) transporter
CD31A_RS08610	COG1114	Component of the transport system for branched-chain amino acids
CD31A_RS08615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD31A_RS08620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CD31A_RS08625	COG0747	negative chemotaxis
CD31A_RS08635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD31A_RS08640	COG4172	Belongs to the ABC transporter superfamily
CD31A_RS08650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CD31A_RS08660	COG0446	pyridine nucleotide-disulphide oxidoreductase
CD31A_RS08680	COG0477	Major facilitator Superfamily
CD31A_RS08700	COG1002	Type II restriction enzyme, methylase subunits
CD31A_RS08735	COG1280	lysine exporter protein (LysE YggA)
CD31A_RS08760	COG1307	EDD domain protein, DegV family
CD31A_RS08765	COG0406	alpha-ribazole phosphatase activity
CD31A_RS08775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CD31A_RS08810	COG1530	ribonuclease E activity
CD31A_RS08825	COG0285	dihydrofolate synthase activity
CD31A_RS08850	COG0512	Glutamine amidotransferase of anthranilate synthase
CD31A_RS08850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CD31A_RS08900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CD31A_RS08910	COG0668	transmembrane transport
CD31A_RS08940	COG1276	copper resistance
CD31A_RS08945	COG1966	Carbon starvation protein
CD31A_RS08965	COG0604	alcohol dehydrogenase
CD31A_RS08985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD31A_RS08990	COG1376	ErfK ybiS ycfS ynhG family protein
CD31A_RS09105	COG4974	Belongs to the 'phage' integrase family
CD31A_RS09135	COG0736	holo-[acyl-carrier-protein] synthase activity
CD31A_RS09140	COG3321	synthase
CD31A_RS09140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD31A_RS09140	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CD31A_RS09155	COG1566	PFAM secretion protein HlyD family protein
CD31A_RS09175	COG1234	tRNA 3'-trailer cleavage
CD31A_RS09190	COG3191	aminopeptidase activity
CD31A_RS09205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CD31A_RS09240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD31A_RS09250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD31A_RS09270	COG1233	COG1233 Phytoene dehydrogenase and related
CD31A_RS09280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CD31A_RS09335	COG0033	Phosphoglucomutase
CD31A_RS09350	COG1136	(ABC) transporter
CD31A_RS09350	COG0577	efflux transmembrane transporter activity
CD31A_RS09355	COG0577	efflux transmembrane transporter activity
CD31A_RS09355	COG1136	(ABC) transporter
CD31A_RS09390	COG2197	response regulator
CD31A_RS09400	COG1045	serine acetyltransferase
CD31A_RS09420	COG0371	Dehydrogenase
CD31A_RS09435	COG1120	ATPase activity
CD31A_RS09445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD31A_RS09460	COG1271	oxidase subunit
CD31A_RS09465	COG1294	oxidase, subunit
CD31A_RS09470	COG4988	ABC transporter
CD31A_RS09475	COG1132	(ABC) transporter
CD31A_RS09515	COG1597	lipid kinase activity
CD31A_RS09560	COG1780	Probably involved in ribonucleotide reductase function
CD31A_RS09565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD31A_RS09575	COG0386	Belongs to the glutathione peroxidase family
CD31A_RS09595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CD31A_RS09600	COG0436	Aminotransferase
CD31A_RS09605	COG0569	domain protein
CD31A_RS09610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CD31A_RS09615	COG0151	Belongs to the GarS family
CD31A_RS09620	COG0537	adenosine 5'-monophosphoramidase activity
CD31A_RS09625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD31A_RS09630	COG2205	protein histidine kinase activity
CD31A_RS09635	COG0745	RESPONSE REGULATOR receiver
CD31A_RS09645	COG0477	Major facilitator Superfamily
CD31A_RS09665	COG0028	Belongs to the TPP enzyme family
CD31A_RS09705	COG1877	trehalose-phosphatase activity
CD31A_RS09710	COG1609	Transcriptional regulator
CD31A_RS09715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CD31A_RS09735	COG1329	Transcriptional regulator
CD31A_RS09740	COG2847	Copper chaperone PCu(A)C
CD31A_RS09750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CD31A_RS09760	COG0288	reversible hydration of carbon dioxide
CD31A_RS09790	COG2267	carboxylic ester hydrolase activity
CD31A_RS09800	COG0295	cytidine deaminase activity
CD31A_RS09805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CD31A_RS09825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CD31A_RS09875	COG1131	(ABC) transporter
CD31A_RS09895	COG1301	dicarboxylic acid transport
CD31A_RS09900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CD31A_RS09925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CD31A_RS09940	COG0302	gtp cyclohydrolase
CD31A_RS09945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD31A_RS09950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CD31A_RS09960	COG2027	D-alanyl-D-alanine carboxypeptidase
CD31A_RS09965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CD31A_RS09970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CD31A_RS10000	COG2326	polyphosphate kinase activity
CD31A_RS10035	COG3547	Transposase (IS116 IS110 IS902 family)
CD31A_RS10065	COG5650	phosphatidylinositol metabolic process
CD31A_RS10085	COG0242	peptide deformylase activity
CD31A_RS10095	COG0708	Exodeoxyribonuclease III
CD31A_RS10100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CD31A_RS10120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CD31A_RS10125	COG0515	serine threonine protein kinase
CD31A_RS10135	COG0280	phosphate acetyltransferase
CD31A_RS10145	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CD31A_RS10150	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CD31A_RS10175	COG4129	membrane
CD31A_RS10185	COG4129	membrane
CD31A_RS10245	COG2801	Transposase and inactivated derivatives
CD31A_RS10255	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS10295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD31A_RS10295	COG2226	methyltransferase
CD31A_RS10295	COG3433	isochorismatase activity
CD31A_RS10305	COG1021	2,3-dihydroxybenzoate-AMP ligase
CD31A_RS10310	COG2226	methyltransferase
CD31A_RS10310	COG3433	isochorismatase activity
CD31A_RS10310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD31A_RS10325	COG1129	ABC transporter
CD31A_RS10330	COG1132	(ABC) transporter
CD31A_RS10335	COG2375	cellular response to nickel ion
CD31A_RS10335	COG1132	(ABC) transporter
CD31A_RS10350	COG0110	maltose O-acetyltransferase activity
CD31A_RS10380	COG2801	Transposase and inactivated derivatives
CD31A_RS10400	COG2801	Transposase and inactivated derivatives
CD31A_RS10415	COG0191	fructose-bisphosphate aldolase activity
CD31A_RS10445	COG0765	amino acid transport
CD31A_RS10465	COG1652	LysM domain
CD31A_RS10470	COG1131	(ABC) transporter
CD31A_RS10525	COG1012	belongs to the aldehyde dehydrogenase family
CD31A_RS10570	COG1012	belongs to the aldehyde dehydrogenase family
CD31A_RS10585	COG0789	Transcriptional regulator
CD31A_RS10605	COG0840	transmembrane signaling receptor activity
CD31A_RS10615	COG4608	Belongs to the ABC transporter superfamily
CD31A_RS10620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD31A_RS10625	COG0601	transmembrane transport
CD31A_RS10665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CD31A_RS10680	COG2181	nitrate reductase activity
CD31A_RS10680	COG0247	lactate metabolic process
CD31A_RS10690	COG1063	alcohol dehydrogenase
CD31A_RS10720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CD31A_RS10740	COG1131	(ABC) transporter
CD31A_RS10770	COG3617	BRO family, N-terminal domain
CD31A_RS10790	COG1132	(ABC) transporter
CD31A_RS10795	COG2375	cellular response to nickel ion
CD31A_RS10795	COG1132	(ABC) transporter
CD31A_RS10815	COG0601	transmembrane transport
CD31A_RS10825	COG1129	ABC transporter
CD31A_RS10830	COG0477	Major facilitator Superfamily
CD31A_RS10835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CD31A_RS10840	COG2814	Major facilitator Superfamily
CD31A_RS10860	COG1472	Belongs to the glycosyl hydrolase 3 family
CD31A_RS10870	COG4981	capsule polysaccharide biosynthetic process
CD31A_RS10885	COG0438	transferase activity, transferring glycosyl groups
CD31A_RS10890	COG0500	methyltransferase
CD31A_RS10935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CD31A_RS10940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD31A_RS10940	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CD31A_RS10940	COG3321	synthase
CD31A_RS10945	COG0318	PFAM AMP-dependent synthetase and ligase
CD31A_RS10950	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CD31A_RS10960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CD31A_RS10960	COG5479	isomerase activity
CD31A_RS10975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CD31A_RS10980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CD31A_RS10990	COG1216	Glycosyl transferase, family 2
CD31A_RS10995	COG0671	phosphoesterase, PA-phosphatase related
CD31A_RS11005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CD31A_RS11030	COG1120	ATPase activity
CD31A_RS11060	COG0656	L-ascorbic acid biosynthetic process
CD31A_RS11080	COG0656	L-ascorbic acid biosynthetic process
CD31A_RS11085	COG0583	DNA-binding transcription factor activity
CD31A_RS11090	COG1002	Type II restriction enzyme, methylase subunits
CD31A_RS11110	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS11135	COG1621	beta-fructofuranosidase activity
CD31A_RS11195	COG2801	Transposase and inactivated derivatives
CD31A_RS11230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CD31A_RS11235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CD31A_RS11240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CD31A_RS11250	COG0561	phosphatase activity
CD31A_RS11260	COG2188	Transcriptional regulator
CD31A_RS11285	COG0077	Prephenate dehydratase
CD31A_RS11305	COG1316	TRANSCRIPTIONal
CD31A_RS11310	COG1115	amino acid carrier protein
CD31A_RS11345	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CD31A_RS11365	COG0431	NADPH-dependent FMN reductase
CD31A_RS11370	COG5650	phosphatidylinositol metabolic process
CD31A_RS11390	COG2197	response regulator
CD31A_RS11405	COG2271	Major facilitator Superfamily
CD31A_RS11415	COG3764	Sortase (surface protein transpeptidase)
CD31A_RS11420	COG0706	membrane insertase activity
CD31A_RS11465	COG1131	(ABC) transporter
CD31A_RS11470	COG2186	Transcriptional regulator
CD31A_RS11480	COG1842	Phage shock protein A
CD31A_RS11485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD31A_RS11500	COG0477	Major facilitator Superfamily
CD31A_RS11505	COG0305	Participates in initiation and elongation during chromosome replication
CD31A_RS11535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CD31A_RS11575	COG0586	Pfam SNARE associated Golgi protein
CD31A_RS11580	COG0783	Belongs to the Dps family
CD31A_RS11590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CD31A_RS11590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CD31A_RS11605	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CD31A_RS11630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CD31A_RS11640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CD31A_RS11650	COG3177	Filamentation induced by cAMP protein fic
CD31A_RS11665	COG2032	superoxide dismutase activity
CD31A_RS11675	COG0577	efflux transmembrane transporter activity
CD31A_RS11675	COG1136	(ABC) transporter
CD31A_RS11690	COG4585	Histidine kinase
CD31A_RS11695	COG2197	response regulator
CD31A_RS11705	COG1511	domain protein
CD31A_RS11710	COG1012	belongs to the aldehyde dehydrogenase family
CD31A_RS11725	COG2376	Dihydroxyacetone kinase
CD31A_RS11730	COG1461	Dihydroxyacetone kinase
CD31A_RS11800	COG0133	tryptophan synthase activity
CD31A_RS11805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CD31A_RS11810	COG0512	Glutamine amidotransferase of anthranilate synthase
CD31A_RS11820	COG0134	indole-3-glycerol-phosphate synthase activity
CD31A_RS11820	COG0135	phosphoribosylanthranilate isomerase activity
CD31A_RS11825	COG2832	Protein of unknown function (DUF454)
CD31A_RS11840	COG0133	tryptophan synthase activity
CD31A_RS11870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CD31A_RS11875	COG1678	Uncharacterized ACR, COG1678
CD31A_RS11880	COG0617	tRNA 3'-terminal CCA addition
CD31A_RS11900	COG1595	DNA-templated transcription, initiation
CD31A_RS11915	COG3409	Peptidoglycan-binding domain 1 protein
CD31A_RS11915	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD31A_RS11925	COG1192	Involved in chromosome partitioning
CD31A_RS11980	COG2826	transposase and inactivated derivatives, IS30 family
CD31A_RS11985	COG2826	transposase and inactivated derivatives, IS30 family